AU2016209332B2 - Pharmaceutical formulation - Google Patents

Pharmaceutical formulation Download PDF

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Publication number
AU2016209332B2
AU2016209332B2 AU2016209332A AU2016209332A AU2016209332B2 AU 2016209332 B2 AU2016209332 B2 AU 2016209332B2 AU 2016209332 A AU2016209332 A AU 2016209332A AU 2016209332 A AU2016209332 A AU 2016209332A AU 2016209332 B2 AU2016209332 B2 AU 2016209332B2
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AU
Australia
Prior art keywords
pharmaceutical composition
enhancing agent
mda
viscosity enhancing
aqueous pharmaceutical
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
AU2016209332A
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English (en)
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AU2016209332A1 (en
Inventor
Mahendra G. Shah
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Semnur Pharmaceuticals Inc
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Semnur Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Semnur Pharmaceuticals Inc filed Critical Semnur Pharmaceuticals Inc
Publication of AU2016209332A1 publication Critical patent/AU2016209332A1/en
Application granted granted Critical
Publication of AU2016209332B2 publication Critical patent/AU2016209332B2/en
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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/66Phosphorus compounds
    • A61K31/661Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion or mevinphos
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02Inorganic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0085Brain, e.g. brain implants; Spinal cord
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/08Solutions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/04Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/06Antigout agents, e.g. antihyperuricemic or uricosuric agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Immunology (AREA)
  • Inorganic Chemistry (AREA)
  • Psychology (AREA)
  • Dermatology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Hydrogenated Pyridines (AREA)
  • Steroid Compounds (AREA)
AU2016209332A 2015-01-21 2016-01-20 Pharmaceutical formulation Active AU2016209332B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562106045P 2015-01-21 2015-01-21
US62/106,045 2015-01-21
PCT/US2016/014165 WO2016118649A1 (en) 2015-01-21 2016-01-20 Pharmaceutical formulation

Publications (2)

Publication Number Publication Date
AU2016209332A1 AU2016209332A1 (en) 2017-09-07
AU2016209332B2 true AU2016209332B2 (en) 2020-10-22

Family

ID=55405453

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2016209332A Active AU2016209332B2 (en) 2015-01-21 2016-01-20 Pharmaceutical formulation

Country Status (13)

Country Link
US (4) US10500284B2 (enExample)
EP (2) EP3247329B3 (enExample)
JP (4) JP6829201B2 (enExample)
KR (2) KR102600792B1 (enExample)
CN (2) CN112957320A (enExample)
AU (1) AU2016209332B2 (enExample)
BR (1) BR112017015452B1 (enExample)
CA (1) CA2974657C (enExample)
ES (1) ES2877371T7 (enExample)
IL (1) IL253570B (enExample)
MX (2) MX386732B (enExample)
TW (3) TWI772659B (enExample)
WO (1) WO2016118649A1 (enExample)

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JP6215354B2 (ja) 2013-01-23 2017-10-18 セムヌール ファーマシューティカルズ, インコーポレイテッド 不溶性コルチコステロイドおよび可溶性コルチコステロイドを含む医薬処方物
TWI772659B (zh) 2015-01-21 2022-08-01 美商桑紐爾製藥公司 醫藥配方
US11857554B2 (en) * 2015-06-02 2024-01-02 Intravital Pty Ltd. Drug delivery device with pre-assembled cartridge
AU2019301542B2 (en) 2018-07-09 2025-04-03 Tlc Biopharmaceuticals, Inc. Methods to reduce complications of intra-articular steroid
IT201800010415A1 (it) * 2018-11-19 2020-05-19 Innate S R L Composizione iniettabile comprendente acido ialuronico e trealosio e uso della detta composizione.
CN112870155B (zh) * 2021-03-08 2023-06-30 上海昱聚科技有限公司 缓释地塞米松药物的凝胶注射剂及其制备方法和应用
WO2024159191A1 (en) * 2023-01-26 2024-08-02 Insignia Pharmaceuticals, Llc Pharmaceutical compositions for treating osteoarthritis
WO2025219919A1 (en) * 2024-04-19 2025-10-23 Beam Medical Inc. Anesthetic pharmaceutical compositions, kits and uses thereof for slow release of an anesthetic agent and concurrent medical imaging of its distribution

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JPH11279065A (ja) * 1998-03-25 1999-10-12 Shiseido Co Ltd 局所投与炎症治療剤
WO2008157057A2 (en) * 2007-06-19 2008-12-24 Warsaw Orthopedic, Inc. Locally administrated low doses of corticosteroids
WO2014116876A1 (en) * 2013-01-23 2014-07-31 Semnur Pharmaceuticals, Inc. Pharmaceutical formulation comprising an insoluble corticosteroid and a soluble corticosteroid

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH11279065A (ja) * 1998-03-25 1999-10-12 Shiseido Co Ltd 局所投与炎症治療剤
WO2008157057A2 (en) * 2007-06-19 2008-12-24 Warsaw Orthopedic, Inc. Locally administrated low doses of corticosteroids
WO2014116876A1 (en) * 2013-01-23 2014-07-31 Semnur Pharmaceuticals, Inc. Pharmaceutical formulation comprising an insoluble corticosteroid and a soluble corticosteroid

Also Published As

Publication number Publication date
JP6829201B2 (ja) 2021-02-10
US11020485B2 (en) 2021-06-01
KR20230157534A (ko) 2023-11-16
KR20170103974A (ko) 2017-09-13
BR112017015452A2 (pt) 2018-01-23
CN112957320A (zh) 2021-06-15
KR102600792B1 (ko) 2023-11-10
JP2020073576A (ja) 2020-05-14
IL253570A0 (en) 2017-09-28
US10500284B2 (en) 2019-12-10
WO2016118649A1 (en) 2016-07-28
TW201630609A (zh) 2016-09-01
HK1243932A1 (zh) 2018-07-27
US20180008714A1 (en) 2018-01-11
US20180185494A1 (en) 2018-07-05
IL253570B (en) 2020-08-31
EP3247329B1 (en) 2021-05-19
TWI772659B (zh) 2022-08-01
AU2016209332A1 (en) 2017-09-07
JP7065129B2 (ja) 2022-05-11
MX386732B (es) 2025-03-19
ES2877371T3 (es) 2021-11-16
US10117938B2 (en) 2018-11-06
KR102824858B1 (ko) 2025-06-26
US12285485B2 (en) 2025-04-29
US20200197523A1 (en) 2020-06-25
ES2877371T7 (es) 2022-05-24
BR112017015452B1 (pt) 2022-11-08
EP3247329A1 (en) 2017-11-29
CA2974657A1 (en) 2016-07-28
CN107205926A (zh) 2017-09-26
EP3925597A1 (en) 2021-12-22
HK1245653A1 (zh) 2018-08-31
JP2021183649A (ja) 2021-12-02
MX2017009482A (es) 2017-11-15
CA2974657C (en) 2024-02-20
JP2021143209A (ja) 2021-09-24
MX2021012029A (es) 2021-10-26
US20210386859A1 (en) 2021-12-16
CN107205926B (zh) 2021-03-05
EP3247329B3 (en) 2022-02-09
JP7269992B2 (ja) 2023-05-09
TW202005652A (zh) 2020-02-01
TW202245791A (zh) 2022-12-01
TWI674899B (zh) 2019-10-21
TWI845973B (zh) 2024-06-21
JP2018502872A (ja) 2018-02-01

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