EP2234619A4 - Methods and compositions for treating intervertebral disc herniations - Google Patents

Methods and compositions for treating intervertebral disc herniations

Info

Publication number
EP2234619A4
EP2234619A4 EP09731572A EP09731572A EP2234619A4 EP 2234619 A4 EP2234619 A4 EP 2234619A4 EP 09731572 A EP09731572 A EP 09731572A EP 09731572 A EP09731572 A EP 09731572A EP 2234619 A4 EP2234619 A4 EP 2234619A4
Authority
EP
European Patent Office
Prior art keywords
compositions
methods
intervertebral disc
disc herniations
treating intervertebral
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP09731572A
Other languages
German (de)
French (fr)
Other versions
EP2234619A2 (en
Inventor
Vanja Margareta King
John Myers Zanella
Jared T Wilsey
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Medtronic Inc
Warsaw Orthopedic Inc
Original Assignee
Medtronic Inc
Warsaw Orthopedic Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US12/105,864 external-priority patent/US8524267B2/en
Priority claimed from US12/396,122 external-priority patent/US9492461B2/en
Application filed by Medtronic Inc, Warsaw Orthopedic Inc filed Critical Medtronic Inc
Publication of EP2234619A2 publication Critical patent/EP2234619A2/en
Publication of EP2234619A4 publication Critical patent/EP2234619A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • A61P5/44—Glucocorticosteroids; Drugs increasing or potentiating the activity of glucocorticosteroids

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
EP09731572A 2008-04-18 2009-04-10 Methods and compositions for treating intervertebral disc herniations Withdrawn EP2234619A4 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US4621808P 2008-04-18 2008-04-18
US12/105,864 US8524267B2 (en) 2008-04-18 2008-04-18 Dexamethasone formulations in a biodegradable material
US12/396,122 US9492461B2 (en) 2008-04-18 2009-03-02 Methods and compositions for treating intervertebral disc herniations
PCT/US2009/040234 WO2009129148A2 (en) 2008-04-18 2009-04-10 Methods and compositions for treating intervertebral disc herniations

Publications (2)

Publication Number Publication Date
EP2234619A2 EP2234619A2 (en) 2010-10-06
EP2234619A4 true EP2234619A4 (en) 2010-10-27

Family

ID=42670674

Family Applications (1)

Application Number Title Priority Date Filing Date
EP09731572A Withdrawn EP2234619A4 (en) 2008-04-18 2009-04-10 Methods and compositions for treating intervertebral disc herniations

Country Status (5)

Country Link
EP (1) EP2234619A4 (en)
JP (1) JP2011513337A (en)
CN (1) CN101918002B (en)
BR (1) BRPI0905078A2 (en)
WO (1) WO2009129148A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9125902B2 (en) * 2010-01-28 2015-09-08 Warsaw Orthopedic, Inc. Methods for treating an intervertebral disc using local analgesics
US9050274B2 (en) * 2010-01-28 2015-06-09 Warsaw Orthopedic, Inc. Compositions and methods for treating an intervertebral disc using bulking agents or sealing agents
AU2014209346B2 (en) * 2013-01-23 2018-11-15 Semnur Pharmaceuticals, Inc. Pharmaceutical formulation comprising an insoluble corticosteroid and a soluble corticosteroid
TWI674899B (en) 2015-01-21 2019-10-21 美商桑紐爾製藥公司 Pharmaceutical formulation
CN110585423A (en) * 2019-10-24 2019-12-20 内蒙古医科大学第二附属医院 Application of IL-6 in preparation of medicine for treating lumbar disc herniation

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007150018A2 (en) * 2006-06-23 2007-12-27 Allergan, Inc. Steroid-containing sustained release intraocular implants and related methods
WO2008030963A1 (en) * 2006-09-08 2008-03-13 Warsaw Orthopedic, Inc. Controlled release systems and methods for osteal growth
WO2008157057A2 (en) * 2007-06-19 2008-12-24 Warsaw Orthopedic, Inc. Locally administrated low doses of corticosteroids

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0489843A4 (en) * 1989-08-28 1992-08-12 Pharmaceutical Delivery Systems, Inc. Bioerodible polymers useful for the controlled release of therapeutic agents
US20050048099A1 (en) * 2003-01-09 2005-03-03 Allergan, Inc. Ocular implant made by a double extrusion process
PL1635875T3 (en) * 2003-06-26 2009-03-31 Psivida Inc In-situ gelling drug delivery system

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007150018A2 (en) * 2006-06-23 2007-12-27 Allergan, Inc. Steroid-containing sustained release intraocular implants and related methods
WO2008030963A1 (en) * 2006-09-08 2008-03-13 Warsaw Orthopedic, Inc. Controlled release systems and methods for osteal growth
WO2008157057A2 (en) * 2007-06-19 2008-12-24 Warsaw Orthopedic, Inc. Locally administrated low doses of corticosteroids

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
BHARDWAJ U ET AL: "Controlling Acute Inflammation with Fast Releasing Dexamethasone-PLGA Microsphere/PVA Hydrogel Composites for Implantable Devices", JOURNAL OF DIABETES SCIENCE AND TECHNOLOGY, DIABETES TECHNOLOGY SOCIETY, US, vol. 1, no. 1, 1 January 2007 (2007-01-01), pages 8 - 17, XP002594754, ISSN: 1932-2968 *
BULLARD J R ET AL: "Epidural steroid treatment of acute herniated nucleus pulposus.", November 1977, ANESTHESIA AND ANALGESIA 1977 NOV-DEC LNKD- PUBMED:73354, VOL. 56, NR. 6, PAGE(S) 862 - 863, ISSN: 0003-2999, XP009138569 *
GREEN: "Dexamethasone in the management of symptoms due to herniated lumbar disc", JOURNAL OF NEUROLOGY, NEUROSURGERY, AND PSYCHIATRY DEC 1975 LNKD- PUBMED:1219086, vol. 38, no. 12, December 1975 (1975-12-01), pages 1211 - 1217, XP002600341, ISSN: 0022-3050 *

Also Published As

Publication number Publication date
JP2011513337A (en) 2011-04-28
WO2009129148A3 (en) 2010-01-28
EP2234619A2 (en) 2010-10-06
BRPI0905078A2 (en) 2015-06-30
CN101918002A (en) 2010-12-15
WO2009129148A2 (en) 2009-10-22
CN101918002B (en) 2013-06-26

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Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

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17P Request for examination filed

Effective date: 20100325

AK Designated contracting states

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Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK TR

AX Request for extension of the european patent

Extension state: AL BA RS

A4 Supplementary search report drawn up and despatched

Effective date: 20100928

DAX Request for extension of the european patent (deleted)
STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20151103