WO2009129148A3 - Methods and compositions for treating intervertebral disc herniations - Google Patents

Methods and compositions for treating intervertebral disc herniations Download PDF

Info

Publication number
WO2009129148A3
WO2009129148A3 PCT/US2009/040234 US2009040234W WO2009129148A3 WO 2009129148 A3 WO2009129148 A3 WO 2009129148A3 US 2009040234 W US2009040234 W US 2009040234W WO 2009129148 A3 WO2009129148 A3 WO 2009129148A3
Authority
WO
WIPO (PCT)
Prior art keywords
intervertebral disc
compositions
methods
disc herniations
treating intervertebral
Prior art date
Application number
PCT/US2009/040234
Other languages
French (fr)
Other versions
WO2009129148A2 (en
Inventor
Vanja Margareta King
John Myers Zanella
Jared T. Wilsey
Original Assignee
Medtronic, Inc.
Warsaw Orthopedic, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US12/105,864 external-priority patent/US8524267B2/en
Priority claimed from US12/396,122 external-priority patent/US9492461B2/en
Application filed by Medtronic, Inc., Warsaw Orthopedic, Inc. filed Critical Medtronic, Inc.
Priority to EP09731572A priority Critical patent/EP2234619A4/en
Priority to BRPI0905078-7A priority patent/BRPI0905078A2/en
Priority to JP2010548947A priority patent/JP2011513337A/en
Priority to CN2009801008192A priority patent/CN101918002B/en
Publication of WO2009129148A2 publication Critical patent/WO2009129148A2/en
Publication of WO2009129148A3 publication Critical patent/WO2009129148A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • A61P5/44—Glucocorticosteroids; Drugs increasing or potentiating the activity of glucocorticosteroids

Abstract

Methods and compositions are provided for treating an intervertebral disc herniation by local administration of one or more biodegradable drug depots comprising a therapeutically effective amount of a glucocorticoid at or near the intervertebral disc herniation to reduce the size of the intervertebral disc herniation.
PCT/US2009/040234 2008-04-18 2009-04-10 Methods and compositions for treating intervertebral disc herniations WO2009129148A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP09731572A EP2234619A4 (en) 2008-04-18 2009-04-10 Methods and compositions for treating intervertebral disc herniations
BRPI0905078-7A BRPI0905078A2 (en) 2008-04-18 2009-04-10 Methods for treating intervertebral disc herniation and reducing the size of an intervertebral disc hernia and implantable drug deposition
JP2010548947A JP2011513337A (en) 2008-04-18 2009-04-10 Methods and compositions for treating disc herniation
CN2009801008192A CN101918002B (en) 2008-04-18 2009-04-10 Methods and compositions for treating intervertebral disc herniations

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US4621808P 2008-04-18 2008-04-18
US12/105,864 2008-04-18
US12/105,864 US8524267B2 (en) 2008-04-18 2008-04-18 Dexamethasone formulations in a biodegradable material
US61/046,218 2008-04-18
US12/396,122 US9492461B2 (en) 2008-04-18 2009-03-02 Methods and compositions for treating intervertebral disc herniations
US12/396,122 2009-03-02

Publications (2)

Publication Number Publication Date
WO2009129148A2 WO2009129148A2 (en) 2009-10-22
WO2009129148A3 true WO2009129148A3 (en) 2010-01-28

Family

ID=42670674

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2009/040234 WO2009129148A2 (en) 2008-04-18 2009-04-10 Methods and compositions for treating intervertebral disc herniations

Country Status (5)

Country Link
EP (1) EP2234619A4 (en)
JP (1) JP2011513337A (en)
CN (1) CN101918002B (en)
BR (1) BRPI0905078A2 (en)
WO (1) WO2009129148A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9125902B2 (en) * 2010-01-28 2015-09-08 Warsaw Orthopedic, Inc. Methods for treating an intervertebral disc using local analgesics
US9050274B2 (en) * 2010-01-28 2015-06-09 Warsaw Orthopedic, Inc. Compositions and methods for treating an intervertebral disc using bulking agents or sealing agents
EP2948182B1 (en) * 2013-01-23 2020-09-30 Semnur Pharmaceuticals, Inc. Pharmaceutical formulation comprising an insoluble corticosteroid and a soluble corticosteroid
TWI674899B (en) 2015-01-21 2019-10-21 美商桑紐爾製藥公司 Pharmaceutical formulation
CN110585423A (en) * 2019-10-24 2019-12-20 内蒙古医科大学第二附属医院 Application of IL-6 in preparation of medicine for treating lumbar disc herniation

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5336505A (en) * 1989-08-28 1994-08-09 Pharmaceutical Delivery Systems Bioerodible polymers useful for the controlled release of therapeutic agents
US20080317805A1 (en) * 2007-06-19 2008-12-25 Mckay William F Locally administrated low doses of corticosteroids

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050048099A1 (en) * 2003-01-09 2005-03-03 Allergan, Inc. Ocular implant made by a double extrusion process
EP1635875B8 (en) * 2003-06-26 2008-12-24 pSivida Inc In-situ gelling drug delivery system
US8642060B2 (en) * 2006-04-24 2014-02-04 Warsaw Orthopedic, Inc. Controlled release systems and methods for osteal growth
US8802128B2 (en) * 2006-06-23 2014-08-12 Allergan, Inc. Steroid-containing sustained release intraocular implants and related methods

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5336505A (en) * 1989-08-28 1994-08-09 Pharmaceutical Delivery Systems Bioerodible polymers useful for the controlled release of therapeutic agents
US20080317805A1 (en) * 2007-06-19 2008-12-25 Mckay William F Locally administrated low doses of corticosteroids

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
RIEW, K.D. ET AL.: "THE EFFECT OF NERVE-ROOT INJECTIONS ON THE NEED FOR OPERATIVE TREATMENT OF LUMBAR RADICULAR PAIN", THE JOURNAL OF BONE AND JOINT SURGERY, vol. 82-A, no. 11, 2000, pages 1589 - 1593, XP009138650 *
See also references of EP2234619A4 *

Also Published As

Publication number Publication date
WO2009129148A2 (en) 2009-10-22
CN101918002A (en) 2010-12-15
JP2011513337A (en) 2011-04-28
EP2234619A2 (en) 2010-10-06
BRPI0905078A2 (en) 2015-06-30
EP2234619A4 (en) 2010-10-27
CN101918002B (en) 2013-06-26

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