JP2021080177A - 複素環化合物及びその用途 - Google Patents
複素環化合物及びその用途 Download PDFInfo
- Publication number
- JP2021080177A JP2021080177A JP2019206311A JP2019206311A JP2021080177A JP 2021080177 A JP2021080177 A JP 2021080177A JP 2019206311 A JP2019206311 A JP 2019206311A JP 2019206311 A JP2019206311 A JP 2019206311A JP 2021080177 A JP2021080177 A JP 2021080177A
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- JP
- Japan
- Prior art keywords
- group
- compound
- examples
- ring
- acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/18—Oxygen atoms
- C07D263/20—Oxygen atoms attached in position 2
- C07D263/22—Oxygen atoms attached in position 2 with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to other ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Psychiatry (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Pyrrole Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Priority Applications (25)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2019206311A JP2021080177A (ja) | 2019-11-14 | 2019-11-14 | 複素環化合物及びその用途 |
| JP2022527713A JP7726879B2 (ja) | 2019-11-14 | 2020-11-12 | 複素環式化合物およびその使用 |
| PE2022000751A PE20221767A1 (es) | 2019-11-14 | 2020-11-12 | Antagonistas heterociclicos de nmda |
| TW109139608A TWI908745B (zh) | 2019-11-14 | 2020-11-12 | 雜環化合物及其用途 |
| CN202080079710.1A CN114728900A (zh) | 2019-11-14 | 2020-11-12 | 杂环类的nmda拮抗剂 |
| CR20220275A CR20220275A (es) | 2019-11-14 | 2020-11-12 | Antagonistas heterocíclicos de nmda |
| PCT/IB2020/000962 WO2021094832A1 (en) | 2019-11-14 | 2020-11-12 | Heterocyclic nmda antagonists |
| CA3158352A CA3158352A1 (en) | 2019-11-14 | 2020-11-12 | Heterocyclic nmda antagonists |
| ARP200103139A AR120452A1 (es) | 2019-11-14 | 2020-11-12 | Compuestos heterocíclicos y usos de los mismos |
| KR1020227019888A KR20220102629A (ko) | 2019-11-14 | 2020-11-12 | 헤테로시클릭 nmda 길항제 |
| AU2020385250A AU2020385250A1 (en) | 2019-11-14 | 2020-11-12 | Heterocyclic NMDA antagonists |
| BR112022008367A BR112022008367A2 (pt) | 2019-11-14 | 2020-11-12 | Antagonistas heterocíclicos de nmda |
| US17/755,907 US20230002318A1 (en) | 2019-11-14 | 2020-11-12 | Heterocyclic nmda antagonists |
| PH1/2022/551173A PH12022551173A1 (en) | 2019-11-14 | 2020-11-12 | Heterocyclic nmda antagonists |
| MX2022005778A MX2022005778A (es) | 2019-11-14 | 2020-11-12 | Antagonistas heterociclicos de nmda. |
| EP20838595.5A EP4058430A1 (en) | 2019-11-14 | 2020-11-12 | Heterocyclic nmda antagonists |
| IL292639A IL292639A (en) | 2019-11-14 | 2022-05-01 | Heterocyclic nmda antagonists |
| JOP/2022/0108A JOP20220108A1 (ar) | 2019-11-14 | 2022-05-10 | مضادات nmda حلقية غير متجانسة |
| CL2022001241A CL2022001241A1 (es) | 2019-11-14 | 2022-05-12 | Antagonistas heterocíclicos de nmda |
| ECSENADI202237602A ECSP22037602A (es) | 2019-11-14 | 2022-05-12 | Antagonistas heterocíclicos de nmda |
| DO2022000099A DOP2022000099A (es) | 2019-11-14 | 2022-05-13 | Antagonistas heterocíclicos de nmda |
| CONC2022/0008012A CO2022008012A2 (es) | 2019-11-14 | 2022-06-06 | Antagonistas heterocíclicos de nmda |
| US18/087,302 US11827601B2 (en) | 2019-11-14 | 2022-12-22 | Heterocyclic NMDA antagonists |
| US18/087,233 US11834409B2 (en) | 2019-11-14 | 2022-12-22 | Heterocyclic NMDA antagonists |
| JP2025132388A JP2025159062A (ja) | 2019-11-14 | 2025-08-07 | 複素環式化合物およびその使用 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2019206311A JP2021080177A (ja) | 2019-11-14 | 2019-11-14 | 複素環化合物及びその用途 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JP2021080177A true JP2021080177A (ja) | 2021-05-27 |
Family
ID=74141594
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019206311A Pending JP2021080177A (ja) | 2019-11-14 | 2019-11-14 | 複素環化合物及びその用途 |
| JP2022527713A Active JP7726879B2 (ja) | 2019-11-14 | 2020-11-12 | 複素環式化合物およびその使用 |
| JP2025132388A Pending JP2025159062A (ja) | 2019-11-14 | 2025-08-07 | 複素環式化合物およびその使用 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022527713A Active JP7726879B2 (ja) | 2019-11-14 | 2020-11-12 | 複素環式化合物およびその使用 |
| JP2025132388A Pending JP2025159062A (ja) | 2019-11-14 | 2025-08-07 | 複素環式化合物およびその使用 |
Country Status (21)
| Country | Link |
|---|---|
| US (3) | US20230002318A1 (https=) |
| EP (1) | EP4058430A1 (https=) |
| JP (3) | JP2021080177A (https=) |
| KR (1) | KR20220102629A (https=) |
| CN (1) | CN114728900A (https=) |
| AR (1) | AR120452A1 (https=) |
| AU (1) | AU2020385250A1 (https=) |
| BR (1) | BR112022008367A2 (https=) |
| CA (1) | CA3158352A1 (https=) |
| CL (1) | CL2022001241A1 (https=) |
| CO (1) | CO2022008012A2 (https=) |
| CR (1) | CR20220275A (https=) |
| DO (1) | DOP2022000099A (https=) |
| EC (1) | ECSP22037602A (https=) |
| IL (1) | IL292639A (https=) |
| JO (1) | JOP20220108A1 (https=) |
| MX (1) | MX2022005778A (https=) |
| PE (1) | PE20221767A1 (https=) |
| PH (1) | PH12022551173A1 (https=) |
| TW (1) | TWI908745B (https=) |
| WO (1) | WO2021094832A1 (https=) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CR20220160A (es) | 2019-09-16 | 2022-06-16 | Takeda Pharmaceuticals Co | Derivados de piridazin-3(2h)-ona fusionados con azol |
| JP2021050161A (ja) | 2019-09-25 | 2021-04-01 | 武田薬品工業株式会社 | 複素環化合物及びその用途 |
| JP2021080177A (ja) | 2019-11-14 | 2021-05-27 | 武田薬品工業株式会社 | 複素環化合物及びその用途 |
| WO2026060343A1 (en) | 2024-09-16 | 2026-03-19 | Neurocrine Biosciences, Inc. | Solid forms comprising a nr2b nam antagonist |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2001500852A (ja) | 1996-08-27 | 2001-01-23 | プレーシス ファーマスーティカルズ インコーポレイテッド | Ｄ―アミノ酸を含むβ―アミロイドペプチド凝集のモジュレーター |
| WO2000017162A1 (en) * | 1998-09-21 | 2000-03-30 | Takeda Chemical Industries, Ltd. | Novel thiol derivatives, process for producing the same and utilization thereof |
| JP2000159747A (ja) * | 1998-09-21 | 2000-06-13 | Takeda Chem Ind Ltd | 新規チオ―ル誘導体、その製造法および用途 |
| CA2374610A1 (en) | 1999-06-28 | 2001-01-04 | Jordan J. N. Tang | Catalytically active recombinant memapsin and methods of use thereof |
| AU1153601A (en) * | 1999-10-29 | 2001-05-08 | Merck Sharp & Dohme Limited | Method to treat pain utilizing benzimidazole NMDA NR2B antagonists |
| JPWO2003035641A1 (ja) * | 2001-10-22 | 2005-02-10 | 塩野義製薬株式会社 | 新規カルバモイルピロリドン誘導体 |
| JP2004002405A (ja) * | 2002-04-26 | 2004-01-08 | Takeda Chem Ind Ltd | 新規チオール誘導体、その製造法および用途 |
| AU2003235121A1 (en) | 2002-04-26 | 2003-11-10 | Takeda Pharmaceutical Company Limited | Novel thiol derivative, process for producing the same and use thereof |
| TW200732313A (en) * | 2005-12-15 | 2007-09-01 | Astrazeneca Ab | Oxazolidinone compounds and their use as metabotropic glutamate receptor potentiators |
| TWI403320B (zh) | 2005-12-16 | 2013-08-01 | Infinity Discovery Inc | 用於抑制ｂｃｌ蛋白和結合夥伴間之交互作用的化合物及方法 |
| WO2009004430A1 (en) * | 2007-06-29 | 2009-01-08 | Pfizer Inc. | N-benzyl oxazolidinones and related heterocycleic compounds as potentiators of glutamate receptors |
| PL3110434T3 (pl) | 2014-02-24 | 2019-01-31 | Takeda Gmbh | Białka fuzyjne uti |
| CN107074788B (zh) * | 2014-10-31 | 2019-09-20 | 厦门大学 | 取代杂环衍生物、其制备方法和用途 |
| WO2018205935A1 (zh) | 2017-05-09 | 2018-11-15 | 浙江大学 | 治疗抑郁症的方法和药物组合物 |
| JP6806735B2 (ja) | 2018-05-30 | 2021-01-06 | 矢崎総業株式会社 | 車両用回路体および車両用回路体の製造方法 |
| WO2020081999A1 (en) | 2018-10-18 | 2020-04-23 | Essa Pharma, Inc. | Androgen receptor modulators and methods for their use |
| CA3134545A1 (en) | 2019-03-28 | 2020-10-01 | Essa Pharma, Inc. | Pharmaceutical compositions and combinations comprising inhibitors of the androgen receptor and uses thereof |
| JP2021080177A (ja) | 2019-11-14 | 2021-05-27 | 武田薬品工業株式会社 | 複素環化合物及びその用途 |
-
2019
- 2019-11-14 JP JP2019206311A patent/JP2021080177A/ja active Pending
-
2020
- 2020-11-12 EP EP20838595.5A patent/EP4058430A1/en active Pending
- 2020-11-12 CN CN202080079710.1A patent/CN114728900A/zh active Pending
- 2020-11-12 TW TW109139608A patent/TWI908745B/zh active
- 2020-11-12 MX MX2022005778A patent/MX2022005778A/es unknown
- 2020-11-12 BR BR112022008367A patent/BR112022008367A2/pt unknown
- 2020-11-12 JP JP2022527713A patent/JP7726879B2/ja active Active
- 2020-11-12 US US17/755,907 patent/US20230002318A1/en active Pending
- 2020-11-12 PE PE2022000751A patent/PE20221767A1/es unknown
- 2020-11-12 AR ARP200103139A patent/AR120452A1/es unknown
- 2020-11-12 AU AU2020385250A patent/AU2020385250A1/en active Pending
- 2020-11-12 WO PCT/IB2020/000962 patent/WO2021094832A1/en not_active Ceased
- 2020-11-12 CR CR20220275A patent/CR20220275A/es unknown
- 2020-11-12 PH PH1/2022/551173A patent/PH12022551173A1/en unknown
- 2020-11-12 CA CA3158352A patent/CA3158352A1/en active Pending
- 2020-11-12 KR KR1020227019888A patent/KR20220102629A/ko active Pending
-
2022
- 2022-05-01 IL IL292639A patent/IL292639A/en unknown
- 2022-05-10 JO JOP/2022/0108A patent/JOP20220108A1/ar unknown
- 2022-05-12 EC ECSENADI202237602A patent/ECSP22037602A/es unknown
- 2022-05-12 CL CL2022001241A patent/CL2022001241A1/es unknown
- 2022-05-13 DO DO2022000099A patent/DOP2022000099A/es unknown
- 2022-06-06 CO CONC2022/0008012A patent/CO2022008012A2/es unknown
- 2022-12-22 US US18/087,233 patent/US11834409B2/en active Active
- 2022-12-22 US US18/087,302 patent/US11827601B2/en active Active
-
2025
- 2025-08-07 JP JP2025132388A patent/JP2025159062A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CN114728900A (zh) | 2022-07-08 |
| US11827601B2 (en) | 2023-11-28 |
| AR120452A1 (es) | 2022-02-16 |
| DOP2022000099A (es) | 2022-08-31 |
| WO2021094832A1 (en) | 2021-05-20 |
| EP4058430A1 (en) | 2022-09-21 |
| CR20220275A (es) | 2023-02-17 |
| PH12022551173A1 (en) | 2024-02-19 |
| WO2021094832A8 (en) | 2022-06-02 |
| JOP20220108A1 (ar) | 2023-01-30 |
| JP7726879B2 (ja) | 2025-08-20 |
| CO2022008012A2 (es) | 2022-06-10 |
| TWI908745B (zh) | 2025-12-21 |
| BR112022008367A2 (pt) | 2022-10-18 |
| US20230134307A1 (en) | 2023-05-04 |
| ECSP22037602A (es) | 2022-06-30 |
| AU2020385250A1 (en) | 2022-06-30 |
| TW202132268A (zh) | 2021-09-01 |
| JP2025159062A (ja) | 2025-10-17 |
| JP2023502030A (ja) | 2023-01-20 |
| CA3158352A1 (en) | 2021-05-20 |
| PE20221767A1 (es) | 2022-11-11 |
| US20230150934A1 (en) | 2023-05-18 |
| US11834409B2 (en) | 2023-12-05 |
| CL2022001241A1 (es) | 2023-02-03 |
| IL292639A (en) | 2022-07-01 |
| KR20220102629A (ko) | 2022-07-20 |
| US20230002318A1 (en) | 2023-01-05 |
| MX2022005778A (es) | 2022-06-09 |
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