JP2021070657A - Oral composition - Google Patents

Abstract

To provide an oral composition that exhibits an outstanding cleaning ability and can remove dental plaque adhering to a tooth surface and can also effectively prevent the dental plaque from adhering to the tooth surface.SOLUTION: An oral composition contains following components (A)-(C): (A) a fatty acid having a C10-22 hydrocarbon group, containing an unsaturated fatty acid of 10 mass% or more relative to the total amount of fatty acid, (B) one or more basic compounds selected from organic amine, alkali metal hydroxide, carbonate, bicarbonate, and sesqui carbonate, and (C) N-acylamino acid or a salt thereof. A molar ratio between the component (A) and component (C) ((A)/(C)) is 0.2 or more and 10.0 or less.SELECTED DRAWING: None

Description

The present invention relates to an oral composition.

Conventionally, in various oral compositions, a fatty acid or a salt thereof is a component widely known as a component capable of exerting a desired action. Among them, fatty acid soaps such as sodium salt and potassium salt of fatty acids are used as detergents, for example, as in the dentin composition described in Patent Document 1.
On the other hand, in the oral composition described in Patent Document 2, a fatty acid salt is blended as a tooth surface coating agent.

JP-A-2009-40756 Japanese Unexamined Patent Publication No. 2000-103726

By the way, in trying to realize a useful oral composition capable of maintaining a good oral environment while using fatty acids, it is possible not only to exhibit high detergency and remove plaque adhering to the tooth surface. It is desired that the composition can effectively prevent plaque from adhering to the tooth surface even after that.
However, although the composition described in Patent Document 1 may exert a plaque removing effect to some extent, further improvement is required to exert a plaque adhesion suppressing effect. On the other hand, in the composition described in Patent Document 2, by blending a fatty acid salt as a tooth surface coating agent, adhesion of bacteria and food debris to teeth is prevented, but an excellent detergency effect is also exhibited. Needs further improvement. As described above, there is still room for study on an oral composition that has both an effect of suppressing plaque adhesion and an effect of exerting an excellent detergency.

Therefore, the present invention has an oral composition capable of exhibiting excellent cleaning ability to remove plaque adhering to the tooth surface and effectively suppressing plaque adhering to the tooth surface. Regarding things.

Therefore, as a result of diligent studies to solve the above problems, the present inventor has determined that N-acylamino acid salt is contained in a specific molar ratio with respect to such fatty acid while containing a specific fatty acid and a specific base. Immediately after application to the oral cavity, such fatty acids mainly form micelle-like aggregates that are rapidly adsorbed on the plaque and detached from the tooth surface, thereby effective in plaque adhering to the tooth surface. It was found that it can be removed as a target. Furthermore, after that, as the composition is gradually diluted with saliva in the oral cavity, the plaque removing effect is sufficiently exerted, and then the coexisting N-acylamino acid salt causes the specific fatty acid to be vesicle-like together with the specific basic compound. It was also found that an assembly of It has also been found that the formed vesicle-like aggregates can densely cover the tooth surface and effectively prevent plaque from adhering to the tooth surface again or newly. That is, in the present invention, an oral composition capable of exhibiting excellent cleaning ability to remove plaque adhering to the tooth surface and effectively exerting an effect of suppressing plaque adhering to the tooth surface. I came to find it.

That is, in the present invention, the following components (A) to (C):
(A) Fatty acid containing 10% by mass or more of unsaturated fatty acid with respect to the total amount of fatty acid and having a hydrocarbon group having 10 or more and 22 or less carbon atoms (B) Organic amine, alkali metal hydroxide, carbonate, bicarbonate , And one or more basic compounds selected from sesquicarbonates (C) N-acyl fatty acids or salts thereof, and the molar ratio of component (A) to component (C) ((A) / (C)) provides an oral composition having a value of 0.2 or more and 10.0 or less.

According to the oral composition of the present invention, immediately after application to the oral cavity, it exhibits excellent cleaning ability and can not only remove plaque adhering to the tooth surface, but also the tooth surface even after cleaning. By effectively suppressing the adhesion of dental plaque to the teeth, it is possible to achieve both the effect of suppressing the adhesion of dental plaque and the effect of exerting an excellent cleaning ability.
Therefore, it is possible to maintain a good oral environment for a long period of time.

Hereinafter, the present invention will be described in detail.
The oral composition of the present invention contains, as the component (A), a fatty acid having a hydrocarbon group having 10 or more and 22 or less carbon atoms, which contains 10% by mass or more of unsaturated fatty acids with respect to the total amount of fatty acids. The carbon number of the hydrocarbon group contained in the fatty acid of the component (A) is 10 or more, preferably 12 or more, more preferably 14 or more, and further preferably 16 from the viewpoint of enhancing the plaque removing effect. It is more than that, more preferably 18 or more, 22 or less, and preferably 20 or less. Examples of such hydrocarbon groups include saturated hydrocarbon groups, unsaturated hydrocarbon groups, linear hydrocarbon groups, and hydrocarbon groups having branched chains. Specifically, for example, capric acid, lauric acid, and myristic acid. , Pentadecylic acid, palmitoleic acid, palmitoleic acid, stearic acid, isostearic acid, oleic acid, linoleic acid, linolenic acid, arachidonic acid, behenic acid and the like.

Further, the component (A) contains a fatty acid having an unsaturated hydrocarbon group, that is, an unsaturated fatty acid. Examples of such unsaturated fatty acids include one or more selected from palmitoleic acid, oleic acid, linoleic acid, linolenic acid and the like. Among them, one or more selected from palmitoleic acid, oleic acid and linoleic acid are preferable, and oleic acid is more preferable, from the viewpoint of achieving both the plaque removing effect and the plaque adhesion suppressing effect.

The content of the unsaturated fatty acid has a hydrocarbon group having 10 or more and 22 or less carbon atoms in 100% by mass of the component (A) from the viewpoint of achieving both the effect of removing the toothpaste and the effect of suppressing the adhesion of the toothpaste. 10% by mass or more, preferably 15% by mass or more, more preferably 25% by mass or more, still more preferably 30% by mass or more, and further preferably 40% by mass or more in the total amount of fatty acids. It is even more preferably 55% by mass or more, even more preferably 75% by mass or more, even more preferably 85% by mass or more, and even more preferably 95% by mass or more.

The content of the component (A) is preferably 0.05 mass by mass in the oral composition of the present invention from the viewpoint of exerting an excellent cleaning effect and effectively removing the plaque adhering to the tooth surface. % Or more, more preferably 0.1% by mass or more, still more preferably 0.2% by mass or more, still more preferably 0.3% by mass or more. Further, the content of the component (A) is from the viewpoint of forming a vesicle-like aggregate with the component (B) described later as the composition is diluted in the oral cavity, and sufficiently exerting the effect of suppressing plaque adhesion. Therefore, in the oral composition of the present invention, it is preferably 5% by mass or less, more preferably 3% by mass or less, more preferably 1.5% by mass or less, still more preferably 0.9% by mass. % Or less. The content of the component (A) is preferably 0.05 to 5% by mass, more preferably 0.1 to 3% by mass, and further preferably 0 in the oral composition of the present invention. It is 2 to 1.5% by mass, more preferably 0.3 to 1% by mass, still more preferably 0.4 to 0.9% by mass.

From the same viewpoint, the content of the component (A) is preferably 2 mmol / L or more, more preferably 4 mmol / L or more, still more preferably 10 mmol / L or more in the oral composition of the present invention. It is L or more, preferably 180 mmol / L or less, more preferably 100 mmol / L or less, and further preferably 30 mmol / L or less.

The oral composition of the present invention contains one or more basic compounds selected from organic amines, alkali metal hydroxides, carbonates, bicarbonates, and sesquicarbonates as the component (B). To do. By containing such a component (B), the component (A) forms a micelle-like aggregate and exerts an effect of removing plaque adhering to the tooth surface, and is diluted with saliva after application to the oral cavity. Along with this, in the coexistence of the component (C) described later, a vesicle-like aggregate can be formed to exert the effect of suppressing plaque adhesion.

Specific examples of the organic amine include one or more basic amino acids selected from, for example, arginine, lysine, and histidine; monoethanolamine, diethanolamine, triethanolamine, morpholine, triisopropanolamine, 2-. Examples thereof include one or more alkanolamine compounds selected from amino-2-methyl-1,3-propanediol and 2-amino-2-methyl-1-propanol.
Specific examples of the alkali metal hydroxide include one or more selected from sodium hydroxide, potassium hydroxide, calcium hydroxide, and lithium hydroxide.
Specific examples of the carbonate, bicarbonate, and sesquicarbonate include one or two selected from, for example, sodium carbonate, potassium carbonate, calcium carbonate, sodium bicarbonate, potassium bicarbonate, and sodium sesquicarbonate. The above can be mentioned.

Among these, arginine, 2-amino-2-methyl-, as the component (B), from the viewpoint of forming a vesicle-like aggregate with the component (A) as the composition is diluted in the oral cavity. One or more selected from 1-propanol, sodium hydroxide, sodium carbonate and sodium bicarbonate is preferable, and one or more selected from arginine and 2-amino-2-methyl-1-propanol is more preferable. Preferably, 2-amino-2-methyl-1-propanol is even more preferred.
Further, from the viewpoint of satisfactorily forming an aggregate of the component (A) and a vesicle-like aggregate and sufficiently exerting the effect of suppressing plaque adhesion, it is preferable to use two or more basic compounds in combination, and more specifically. It is more preferable to use two or more kinds selected from arginine, 2-amino-2-methyl-1-propanol and sodium bicarbonate in combination, and two kinds of arginine and 2-amino-2-methyl-1-propanol are used. It is more preferable to use them together.

The content of the component (B) is the present invention from the viewpoint of forming a vesicle-like aggregate with the component (A) when the composition is diluted in the oral cavity and sufficiently exerting the effect of suppressing plaque adhesion. In the oral composition of the above, it is preferably 8 mmol / L or more, more preferably 12 mmol / L or more, and further preferably 20 mmol / L or more. The content of the component (B) is preferably 200 mmol / L or less in the oral composition of the present invention, mainly from the viewpoint of ensuring an excellent cleaning effect of the component (A) when applied into the oral cavity. It is more preferably 150 mmol / L or less, and further preferably 100 mmol / L or less. The content of the component (B) in the oral composition of the present invention is preferably 8 to 200 mmol / L, more preferably 12 to 150 mmol / L, and even more preferably 20 to 100 mmol / L. Is.

The molar ratio of the component (B) to the component (A) ((B) / (A)) is preferably 0.5 or more from the viewpoint of achieving both the plaque removing effect and the plaque adhesion suppressing effect. , More preferably 0.8 or more, still more preferably 2 or more, preferably 10 or less, more preferably 8 or less, still more preferably 6 or less. The molar ratio ((B) / (A)) of the component (B) to the component (A) is preferably 0.5 to 10, more preferably 0.8 to 8, and even more preferably 2. ~ 6.

The oral composition of the present invention contains N-acylamino acid or a salt thereof as the component (C). In the case of an oral composition containing such a component (C), immediately after it is first applied into the oral cavity, the component (A) mainly forms a micelle-like aggregate and is rapidly adsorbed on plaque. It can be separated from the tooth surface and the plaque stuck to the tooth surface can be effectively removed. Then, as the composition is gradually diluted with saliva in the oral cavity, the plaque removing effect is sufficiently exerted, and then the coexisting component (C) forms a vesicle-like aggregate together with the components (A) to (B). Will be done. Then, the formed vesicle-like aggregates densely cover the tooth surface, and it is possible to effectively suppress the re-or new adhesion of plaque to the tooth surface, resulting in an excellent plaque removing effect and teeth. It is possible to achieve both the effect of suppressing plaque adhesion.

As the constituent unit of the component (C), that is, the amino acid portion of the so-called N-acylamino acid, a constituent unit derived from glutamic acid and a constituent unit derived from glycine are used from the viewpoint of achieving both an excellent plaque removing effect and a plaque adhesion suppressing effect. One or two types selected from the units are preferable, and a constituent unit derived from glutamic acid is more preferable. Further, the amino acid portion which is these constituent units may be any of D-form, L-form, or a mixture of D-form and L-form, and is preferably L-form.

The acyl group of the N-acyl fatty acid in the component (C) preferably has a hydrocarbon group having 12 to 18 carbon atoms, and is saturated, from the viewpoint of achieving both an excellent effect of removing the plaque and an effect of suppressing the adhesion of the plaque. Alternatively, it may be derived from a fatty acid having an unsaturated straight chain or a branched chain or a mixed fatty acid thereof, or a plurality of types of hydrocarbon groups having different carbon atoms may be mixed. Specifically, as the acyl group of the N-acyl amino acid in the component (C), one or more selected from a lauroyl group, a myristoylation group, and a cocoyl group is preferable. Of these, a lauroyl group is preferable.

Examples of the salt of the alkali metal salt of N-acylamino acid in the component (C) include sodium and potassium.

The content of the component (C) is the oral composition of the present invention from the viewpoint of advancing the transition from the micelle-like aggregate to the vesicle-like aggregate by the above component (A) and the component (B) at an appropriate time. In terms of acid equivalent, it is preferably 0.01% by mass or more, more preferably 0.05% by mass or more, more preferably 0.1% by mass or more, and further preferably 0.2% by mass. % Or more, more preferably 0.3% by mass or more, still more preferably 0.45% by mass or more, still more preferably 0.55% by mass or more. Further, the content of the component (C) is preferably 2% by mass or less in terms of acid in the oral composition of the present invention from the viewpoint of maintaining a good flavor and the like, and more preferably 1. It is 4% by mass or less, more preferably 0.7% by mass or less. The content of the component (C) in the oral composition of the present invention is preferably 0.01 to 2% by mass, more preferably 0.05 to 1.4% by mass in terms of acid. It is more preferably 0.1 to 0.7% by mass, further preferably 0.2 to 0.7% by mass, still more preferably 0.3 to 0.7% by mass, and further preferably. Is 0.45 to 0.7% by mass, more preferably 0.55 to 0.7% by mass.

The molar ratio of component (A) to component (C) ((A) / (C)) shows the transition from micelle-like aggregates to vesicle-like aggregates by the above components (A) and (B). From the viewpoint of advancing to an appropriate time, it is 0.2 or more, preferably 0.5 or more, 10 or less, preferably 8 or less, more preferably 3 or less, still more preferably 2. It is as follows. The molar ratio ((A) / (C)) of the component (A) to the component (C) is 0.2 or more and 10 or less, preferably 0.5 to 8, and more preferably 0. It is .5 to 3, and more preferably 0.5 to 2.

The oral composition of the present invention preferably contains water from the viewpoint that each component can be satisfactorily dispersed or dissolved and satisfactorily diffused in the oral cavity while maintaining good shape retention. The water in the present invention includes not only purified water and the like blended in the oral composition, but also water contained in each blended component such as a 70% sorbitol solution (aqueous solution) used at the time of formulation. It means the total water contained in the oral composition.

Specifically, when the oral composition of the present invention is a liquid oral composition such as a mouthwash or a liquid dentifrice, the content of such water is preferably in the oral composition of the present invention. It is 50% by mass or more, more preferably 70% by mass or more, further preferably 80% by mass or more, preferably 99% by mass or less, and more preferably 98% by mass or less. When the oral composition of the present invention is a liquid oral composition such as a mouthwash or a liquid dentifrice, the content of such water is preferably 50 to 99 in the oral composition of the present invention. It is by mass, more preferably 70 to 98% by mass, and even more preferably 80% by mass or more and less than 98% by mass.
Further, when the oral composition of the present invention is a dentifrice composition such as a dentifrice or a powdered dentifrice, the content of such water is preferably 5% by mass or more in the oral composition of the present invention. Yes, more preferably 10% by mass or more, preferably 60% by mass or less, and more preferably 55% by mass or less. When the oral composition of the present invention is a dentifrice composition such as a dentifrice or a dentifrice powder, the content of such water is preferably 5 to 60% by mass, more preferably 10 to 55% by mass. %.

When the oral composition of the present invention is a dentifrice composition such as a dentifrice or a powdered dentifrice, the water content thereof can be calculated from the water content of the blended water content and the water content of the blended ingredients. For example, it can be measured with a Karl Fischer titer. As the Karl Fischer titer, for example, a trace moisture measuring device (manufactured by Hiranuma Sangyo Co., Ltd.) can be used. In this device, 5 g of the toothpaste composition is taken, suspended in 25 g of anhydrous methanol, and 0.02 g of this suspension can be separated to measure the water content.

When the oral composition of the present invention is a dentifrice composition such as a dentifrice or a powdered dentifrice, the composition stays and diffuses in the vicinity of the tooth surface while having an appropriate viscosity, and has an excellent plaque removing effect. It is preferable to contain a binder from the viewpoint of sufficiently exerting both the effect of suppressing plaque adhesion and the effect of suppressing plaque adhesion. Specific examples of such a binder include cellulosic binders such as carboxymethyl cellulose or a salt thereof, hydroxyethyl cellulose or a salt thereof, hydroxypropyl cellulose or a salt thereof; sodium alginate, carrageenan, xanthan gum, and polyacrylic acid. Stickiness other than cellulosic binders such as sodium, pectin, tragant gum, arabic gum, guar gum, carrageenan gum, locust bean gum, gellan gum, tamarind gum, psyllium seed gum, polyvinyl alcohol, sodium chondroitin sulfate and methoxyethylene maleic anhydride copolymer One or more selected from the binders can be mentioned.
The content of such a binder in the oral composition of the present invention is preferably 0.1 to 2.0% by mass, more preferably 0.3 to 1.5% by mass, and even more preferably. Is 0.5 to 1.0% by mass.

When the oral composition of the present invention is a dentifrice composition such as a dentifrice or a dentifrice powder, from the viewpoint of imparting an appropriate viscosity and further achieving both a plaque removing effect and a plaque adhesion suppressing effect. Along with the above-mentioned binder, thickening silica having an oil absorption amount of 200 mL / 100 g or more and 400 mL / 100 g or less may be contained. The content of such thickening silica is preferably 1 to 15% by mass, more preferably 2 to 10% by mass in the oral composition of the present invention.

When the oral composition of the present invention is a dentifrice composition such as a dentifrice or a powdered dentifrice, the content of free divalent metal ions can be restricted as described later from the viewpoint of further enhancing the plaque removing effect. Within the range, it is possible to further contain an abrasive. Examples of the abrasive include aluminum hydroxide, aluminum silicate, zirconium silicate, and abrasive silica (oil absorption measured according to JIS K5101-13-2 is 50 to 150 mL / 100 g). As the abrasive, those having an RDA value (Radioactive Dentine Abrasion values, value measured according to ISO11609 Abrasion Test Method Annex A) of 20 to 250 are generally used. The content of such an abrasive is preferably 1 to 20% by mass, more preferably 5 to 15% by mass in the oral composition of the present invention.

The oral composition of the present invention does not inhibit the component (A) and the component (B) from forming a vesicle-like aggregate and exerting a plaque adhesion suppressing effect when applied into the oral cavity. , It is preferable to limit the content of free divalent metal ions. Specific examples of such free divalent metal ions include calcium ions and magnesium ions. The content of such free divalent metal ions in the oral composition of the present invention is preferably 0.5% by mass or less, more preferably 0.1% by mass or less, still more preferably 0. It is preferably 05% by mass or less, or the oral composition of the present invention does not contain free divalent metal ions.
The content of such free divalent metal ions is a value measured as the total amount of free divalent metal ions by ICP emission spectrometry (ICP emission spectrometer: Optima 5300DV manufactured by Perkin Elmer).

In addition to the above components, the oral composition of the present invention contains nonionic surfactants such as polyoxyethylene hydrogenated castor oil and sucrose fatty acid ester; isopropylmethylphenol and cetyl chloride, as long as the effects of the present invention are not impaired. Bactericides such as pyridinium; sugar alcohols such as sorbitol, xylitol and erythritol; wetting agents such as glycerin; preservatives; fluorides and other medicinal agents; pigments; pigments; fragrances and the like can be appropriately contained.

The pH of the oral composition of the present invention at 25 ° C. is not affected by fluctuations in the pH environment in the oral cavity during use, and it is possible to sufficiently achieve both the plaque removing effect and the plaque adhesion suppressing effect. Therefore, it is not particularly limited, but from the viewpoint of ensuring a good usability, it is preferably 7.5 or more, more preferably 8.0 or more, still more preferably 8.5 or more, and preferably 10 It is 0.0 or less, more preferably 9.5 or less, and even more preferably 9.3 or less. The pH of the oral composition of the present invention at 25 ° C. is preferably 7.5 to 10.0, more preferably 8.0 to 9.5, and even more preferably 8.5 to 9. It is 3.

With respect to the embodiments described above, the present invention further discloses the following oral compositions.
[1] The following components (A) to (C):
(A) Fatty acid containing 10% by mass or more of unsaturated fatty acid with respect to the total amount of fatty acid and having a hydrocarbon group having 10 or more and 22 or less carbon atoms (B) Organic amine, alkali metal hydroxide, carbonate, bicarbonate , And one or more basic compounds selected from sesquicarbonates (C) N-acyl fatty acids or salts thereof, and the molar ratio of component (A) to component (C) ((A) / (C)) is 0.2 or more and 10.0 or less.
[2] In the component (A), the unsaturated fatty acid is one or more selected from palmitoleic acid, oleic acid, linoleic acid, linolenic acid and the like, and preferably selected from palmitoleic acid, oleic acid and linolenic acid. The above-mentioned oral composition according to the above [1], which is one kind or two or more kinds, more preferably oleic acid.
[3] The content of the unsaturated fatty acid is 10% by mass or more, preferably 15% by mass or more, more preferably 25% by mass or more, and further preferably 25% by mass or more in 100% by mass of the component (A). Is 30% by mass or more, more preferably 40% by mass or more, still more preferably 55% by mass or more, still more preferably 75% by mass or more, still more preferably 85% by mass or more. Yes, more preferably 95% by mass or more of the above-mentioned oral composition of [1] or [2].
[4] The content of the component (A) is preferably 0.05% by mass or more, more preferably 0.1% by mass or more, still more preferably 0.2% by mass or more, still more preferably. 0.3% by mass or more, preferably 5% by mass or less, more preferably 3% by mass or less, more preferably 1.5% by mass or less, still more preferably 0.9% by mass or less. An oral composition according to any one of the above [1] to [3].

[5] The component (B) is preferably one or more selected from arginine, 2-amino-2-methyl-1-propanol, sodium hydroxide, sodium carbonate and sodium bicarbonate, and more preferably. One or more selected from arginine and 2-amino-2-methyl-1-propanol, more preferably 2-amino-2-methyl-1-propanol, and two or more basic compounds. It is preferable to use them in combination, and more specifically, it is more preferable to use two or more kinds selected from arginine, 2-amino-2-methyl-1-propanol and sodium bicarbonate in combination, and arginine and 2-amino-2 are used in combination. The oral composition according to any one of the above [1] to [4], which is more preferably used in combination with two types of -methyl-1-propanol.
[6] The content of the component (B) is 8 mmol / L or more, more preferably 12 mmol / L or more, further preferably 20 mmol / L or more, preferably 200 mmol / L or less, and more preferably. The oral composition according to any one of the above [1] to [5], which is 150 mmol / L or less, more preferably 100 mmol / L or less.
[7] The molar ratio ((B) / (A)) of the component (B) to the component (A) is preferably 0.5 or more, more preferably 0.8 or more, and further preferably 2 or more. The oral composition according to any one of the above [1] to [6], preferably 10 or less, more preferably 8 or less, and further preferably 6 or less.

[8] The structural unit contained in the component (C) is preferably one or two selected from the structural unit derived from glutamic acid and the structural unit derived from glycine, and more preferably the structural unit derived from glutamic acid. The oral composition according to any one of [1] to [7] above, wherein the acyl group of the N-acyl amino acid in C) is preferably one or more selected from a lauroyl group, a myritoyl group, and a cocoyl group.
[9] The content of the component (C) is preferably 0.01% by mass or more, more preferably 0.05% by mass or more, and more preferably 0.1% by mass or more in terms of acid. Yes, more preferably 0.2% by mass or more, even more preferably 0.3% by mass or more, still more preferably 0.45% by mass or more, still more preferably 0.55% by mass or more. The oral composition according to any one of the above [1] to [8], preferably 2% by mass or less, more preferably 1.4% by mass or less, and more preferably 0.7% by mass or less. Stuff.
[10] The molar ratio ((A) / (C)) of the component (A) to the component (C) is preferably 0.5 or more, preferably 8 or less, and more preferably 3 or less. The oral composition according to any one of the above [1] to [9], more preferably 2 or less.
[11] The content of water is preferably 50% by mass or more, more preferably 70% by mass or more, further preferably 80% by mass or more, preferably 99% by mass or less, and more preferably. The oral composition according to any one of the above [1] to [10], which is 98% by mass or less.
[12] The pH at 25 ° C. is preferably 7.5 or more, more preferably 8.0 or more, still more preferably 8.5 or more, preferably 10.0 or less, and more preferably. The oral composition according to any one of the above [1] to [11], which is 9.5 or less, more preferably 9.0 or less.

Hereinafter, the present invention will be specifically described based on examples. Unless otherwise specified in the table, the content of each component indicates mass%.

[Examples 1 to 18, Comparative Examples 1 to 3]
Oral compositions were prepared according to the formulations shown in Table 1. Using each of the obtained oral compositions, each measurement and evaluation was performed according to the following method. The content of the component (C) in Table 1 is shown in terms of acid.
The results are shown in Table 1.
When the pH of Examples 1 to 3 was measured at 25 ° C. (Measuring machine: F-53 manufactured by HORIBA, Ltd.), Example 1 = pH 9.1, Example 2 = pH 8.9, Example 3 = The pH was 8.8.

[Evaluation of plaque removal]
1) Collection of stimulated saliva For healthy men in their 20s and 30s, chew gum pellets contained in the dent buff strip (manufactured by Oral Care), and spit out saliva accumulated in the mouth into a falcon tube each time. Saliva was collected in such a falcon tube. Since there are individual differences in the bacteria in saliva, the saliva of one healthy man was used to evaluate all the examples and comparative examples.

2) Preparation of plaque model Saliva collected in a falcon tube was centrifuged at 3000 rpm / 25 ° C./10 min (centrifuge device name: cooling centrifuge CF15RN, manufactured by Hitachi, Ltd.). Using the separated supernatant saliva, sucrose was added so as to be a 5% by mass solution, and then the mixture was stirred using a stirring device (voltex, manufactured by Nippon Genetics Co., Ltd.) to prepare a plaque model test solution.
Next, one side of the HAp substrate (manufactured by Cosmo Bio Co., Ltd., 1 cm square) was mirror-polished using abrasive paper of 40 μm, 12 μm, and 3 μm, and then immersed in 1N HCl for 1 minute for acid decalcification. The treated HAp plate was washed with ion-exchanged water, dried, placed in a 24-well plate, and 1 mL of the above-prepared plaque model test solution was added. Then, the HAp substrate _{was stored in a plastic case together with a CO 2} pack under anaerobic conditions, and cultured at 37 ° C. for 48 hours.

3) Evaluation of plaque removing effect The saliva in the plate was sucked up using a decompression pump, 1 mL of ion-exchanged water was added, and the mixture was shaken for 5 minutes. Next, water was sucked up using a pump, and a solution prepared by adding 0.13 mL of artificial saliva to 1 mL of each composition obtained in Examples and Comparative Examples was separately prepared in a 24-well plate. Then, the HAp substrate on which the model plaque was formed was immersed in the prepared solution and shaken for 1 minute. The shaking was performed using a shaking machine (BioShake iQ (manufactured by Waken Betec)) at room temperature (25 ° C.) and 500 rpm.
Then, each composition was sucked up, 1 mL of ion-exchanged water was added, and the mixture was shaken for 5 minutes, and this was repeated 3 times. Then, the ion-exchanged water was absorbed, 750 μL of 0.1% by mass crystal violet (CV) staining solution was added, and the mixture was shaken for 15 minutes.
Further, the CV staining solution was sucked up with a pump, 1 mL of ion-exchanged water was added, and the mixture was shaken for 5 minutes, and this was repeated twice. Next, water is sucked up with a pump, 500 μL of ethanol is added and pipetting is performed, and then the extract is diluted 10-fold with ion-exchanged water and used with a microplate recorder (TECAN's variable wavelength absorbance microplate reader Sunrise Rainbow Thermo). Absorbance OD _{595 nm} was measured.
Further, the plaque removal rate (%) was calculated according to the following formula based on _{the absorbance OD 595 nm} (initial value) only washed with ion-exchanged water without using the obtained composition.
The larger the value of the obtained plaque removal rate, the higher the plaque removal effect.
Plaque removal ratio (%) = 100- × 100 { OD 595nm only washed with OD _{595 nm} / ion-exchanged water at the time of using the resulting composition}

[Evaluation of suppression of plaque formation]
1) Treatment with composition One side of a HAp substrate (manufactured by Cosmo Bio Co., Ltd., 1 cm square) is mirror-polished with 40 μm, 12 μm, and 3 μm abrasive paper, and then immersed in 1N HCl for 1 minute for acid decalcification. gave. The treated HAp plate was washed with ion-exchanged water, dried, placed in a 24-well plate, 1 mL of each composition obtained in Examples and Comparative Examples, and 0.13 mL of artificial saliva were added and shaken for 5 minutes. .. The shaking was performed using a shaking machine (BioShake iQ (manufactured by Waken Betec)) at room temperature (25 ° C.) and 500 rpm. Then, each composition was sucked up, 1 mL of ion-exchanged water was added, and the mixture was shaken for 5 minutes, and then the water was sucked up and used as a treated substrate.

2) Collection of stimulating saliva For healthy men in their 20s and 30s, chew the gum pellets contained in the dent buff strip (manufactured by Oral Care), and spit out the saliva accumulated in the mouth into the Falcon tube each time. Saliva was collected in such a falcon tube. Since there are individual differences in the bacteria in saliva, a plaque formation suppression test was conducted on all the examples and comparative examples using the saliva of one healthy man.

3) Formation of model plaque The saliva collected in the Falcon tube was centrifuged at 3000 rpm / 25 ° C./10 min using a cooling centrifuge (CF15RN, manufactured by Hitachi, Ltd.). Using the separated supernatant saliva, sucrose was added so as to be a 5% by mass solution, and then the mixture was stirred using a stirring device (voltex, manufactured by Nippon Genetics Co., Ltd.) to prepare a plaque model test solution.
Next, after adding 1 mL each of the plaque model test solution prepared above to the HAp substrate treated in 1), this _{was stored in a plastic case together with a CO 2} pack under anaerobic conditions, and at 37 ° C. 48. Incubated for hours.

4) Evaluation of plaque formation inhibitory effect Using a decompression pump, saliva in the plate was sucked up, 1 mL of ion-exchanged water was added, and the mixture was shaken once for 5 minutes. The water was then sucked up using a pump, 750 μL of 0.1 mass% crystal violet (CV) solution was added and shaken for 15 minutes.
Further, the CV staining solution was sucked up with a pump, 1 mL of ion-exchanged water was added, and the mixture was shaken for 5 minutes, and this was repeated twice. Next, water is sucked up with a pump, 500 μL of ethanol is added and pipetting is performed, and then the extract is diluted 10-fold with ion-exchanged water and used with a microplate recorder (TECAN's variable wavelength absorbance microplate reader Sunrise Rainbow Thermo). Absorbance OD _{595 nm} was measured.
Further, the plaque formation inhibition rate (%) was calculated according to the following formula based on _{the absorbance OD 595 nm} (initial value) only washed with ion-exchanged water without using the obtained composition.
The larger the value of the obtained plaque formation suppressing rate, the higher the plaque formation suppressing effect.
Plaque formation inhibition rate (%) = 100- × 100 { OD 595nm of OD _{595 nm} / unprocessed substrate board treated in the above obtained composition}

As the oral composition of the present invention, the oral composition of the formulation shown in Table 2 can be prepared.

Claims (6)

The following components (A) to (C):
(A) Fatty acid containing 10% by mass or more of unsaturated fatty acid with respect to the total amount of fatty acid and having a hydrocarbon group having 10 or more and 22 or less carbon atoms (B) Organic amine, alkali metal hydroxide, carbonate, bicarbonate , And one or more basic compounds selected from sesquicarbonates (C) N-acyl fatty acids or salts thereof, and the molar ratio of component (A) to component (C) ((A) / (C)) is 0.2 or more and 10.0 or less. The oral composition according to claim 1, wherein the content of the component (A) is 0.05% by mass or more and 5% by mass or less. The oral composition according to claim 1 or 2, wherein the molar ratio ((B) / (A)) of the component (B) to the component (A) is 1.0 or more and 10.0 or less. The oral composition according to any one of claims 1 to 3, wherein the component (C) has a structural unit derived from glutamic acid. The oral composition according to any one of claims 1 to 4, wherein the unsaturated fatty acid in the component (A) is one or more selected from palmitoleic acid, oleic acid, linoleic acid and linolenic acid. The oral composition according to any one of claims 1 to 5, wherein the component (B) is two or more basic compounds.