JP2021061852A5 - - Google Patents
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- Publication number
- JP2021061852A5 JP2021061852A5 JP2021001276A JP2021001276A JP2021061852A5 JP 2021061852 A5 JP2021061852 A5 JP 2021061852A5 JP 2021001276 A JP2021001276 A JP 2021001276A JP 2021001276 A JP2021001276 A JP 2021001276A JP 2021061852 A5 JP2021061852 A5 JP 2021061852A5
- Authority
- JP
- Japan
- Prior art keywords
- protein
- library
- candidate protein
- binding site
- candidate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562165173P | 2015-05-21 | 2015-05-21 | |
| US62/165,173 | 2015-05-21 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017556995A Division JP6867302B2 (ja) | 2015-05-21 | 2016-05-16 | タンパク質の特徴を改善する方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021061852A JP2021061852A (ja) | 2021-04-22 |
| JP2021061852A5 true JP2021061852A5 (https=) | 2021-07-29 |
| JP7109605B2 JP7109605B2 (ja) | 2022-07-29 |
Family
ID=57320465
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017556995A Active JP6867302B2 (ja) | 2015-05-21 | 2016-05-16 | タンパク質の特徴を改善する方法 |
| JP2021001276A Active JP7109605B2 (ja) | 2015-05-21 | 2021-01-07 | タンパク質の特徴を改善する方法 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017556995A Active JP6867302B2 (ja) | 2015-05-21 | 2016-05-16 | タンパク質の特徴を改善する方法 |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US10526597B2 (https=) |
| EP (1) | EP3297661B1 (https=) |
| JP (2) | JP6867302B2 (https=) |
| ES (1) | ES2881683T3 (https=) |
| WO (1) | WO2016187101A2 (https=) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2881683T3 (es) | 2015-05-21 | 2021-11-30 | Full Spectrum Genetics Inc | Procedimiento para mejorar las características de las proteínas |
| US9708412B2 (en) | 2015-05-21 | 2017-07-18 | Harpoon Therapeutics, Inc. | Trispecific binding proteins and methods of use |
| EP3493844A4 (en) | 2016-05-20 | 2021-03-24 | Harpoon Therapeutics Inc. | SINGLE DOMAIN SERUM ALBUMIN BINDING PROTEIN |
| US11623958B2 (en) | 2016-05-20 | 2023-04-11 | Harpoon Therapeutics, Inc. | Single chain variable fragment CD3 binding proteins |
| WO2018098356A1 (en) | 2016-11-23 | 2018-05-31 | Harpoon Therapeutics, Inc. | Psma targeting trispecific proteins and methods of use |
| AU2017363300A1 (en) | 2016-11-23 | 2019-06-20 | Harpoon Therapeutics, Inc. | Prostate specific membrane antigen binding protein |
| US11535668B2 (en) | 2017-02-28 | 2022-12-27 | Harpoon Therapeutics, Inc. | Inducible monovalent antigen binding protein |
| EP3621994A4 (en) | 2017-05-12 | 2020-12-30 | Harpoon Therapeutics, Inc. | MESOTHELIN BINDING PROTEINS |
| WO2018209304A1 (en) | 2017-05-12 | 2018-11-15 | Harpoon Therapeutics, Inc. | Msln targeting trispecific proteins and methods of use |
| MX2020003915A (es) | 2017-10-13 | 2020-10-08 | Harpoon Therapeutics Inc | Proteinas trispecificas y metodos de uso. |
| IL315737A (en) | 2017-10-13 | 2024-11-01 | Harpoon Therapeutics Inc | B-cell maturation antigen-binding proteins |
| BR112020023330A2 (pt) | 2018-05-14 | 2021-04-20 | Harpoon Therapeutics, Inc. | porção de ligação para ativação condicional de moléculas de imunoglobulina |
| US12195544B2 (en) | 2018-09-21 | 2025-01-14 | Harpoon Therapeutics, Inc. | EGFR binding proteins and methods of use |
| US10815311B2 (en) | 2018-09-25 | 2020-10-27 | Harpoon Therapeutics, Inc. | DLL3 binding proteins and methods of use |
| AU2020275002A1 (en) | 2019-05-14 | 2021-12-23 | Harpoon Therapeutics, Inc. | EpCAM binding proteins and methods of use |
| CN115768463A (zh) | 2020-02-21 | 2023-03-07 | 哈普恩治疗公司 | Flt3结合蛋白及使用方法 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2079802C (en) | 1990-04-05 | 2001-09-18 | Roberto Crea | Walk-through mutagenesis |
| US5605793A (en) | 1994-02-17 | 1997-02-25 | Affymax Technologies N.V. | Methods for in vitro recombination |
| US6117679A (en) * | 1994-02-17 | 2000-09-12 | Maxygen, Inc. | Methods for generating polynucleotides having desired characteristics by iterative selection and recombination |
| AU1456101A (en) | 1999-11-03 | 2001-05-14 | Maxygen, Inc. | Antibody diversity generation |
| ATE384129T1 (de) * | 2001-11-22 | 2008-02-15 | Univ Keio | Künstliche antikörperbibliothek mit super- repertoire |
| EP2272566A3 (en) | 2003-08-18 | 2013-01-02 | MedImmune, LLC | Humanisation of antibodies |
| US20060228350A1 (en) | 2003-08-18 | 2006-10-12 | Medimmune, Inc. | Framework-shuffling of antibodies |
| US20060160178A1 (en) * | 2003-11-17 | 2006-07-20 | Jonathan Rothberg | Methods of generating antibody diversity in vitro |
| CA2572917C (en) | 2004-07-06 | 2012-04-03 | Bioren Inc. | Look-through mutagenesis for developing altered polypeptides with enhanced properties |
| US8633139B2 (en) | 2007-12-21 | 2014-01-21 | Abbvie Biotherapeutics Inc. | Methods of screening complex protein libraries to identify altered properties |
| US20120077691A1 (en) | 2010-09-24 | 2012-03-29 | Full Spectrum Genetics, Inc. | Method of analyzing binding interactions |
| JP5920835B2 (ja) * | 2010-12-01 | 2016-05-18 | 田辺三菱製薬株式会社 | 無細胞翻訳系でＦａｂを提示しうるポリヌクレオチド構築物ならびにそれを用いたＦａｂの製造方法およびスクリーニング方法 |
| US20120258866A1 (en) | 2011-04-05 | 2012-10-11 | Full Spectrum Genetics, Inc. | Multi-dimensional selection of protein mutants using high throughput sequence analysis |
| US10947305B2 (en) | 2015-03-20 | 2021-03-16 | Full Spectrum Genetics, Inc. | Anti-TNFα binding compounds and uses thereof |
| ES2881683T3 (es) | 2015-05-21 | 2021-11-30 | Full Spectrum Genetics Inc | Procedimiento para mejorar las características de las proteínas |
-
2016
- 2016-05-16 ES ES16797078T patent/ES2881683T3/es active Active
- 2016-05-16 EP EP16797078.9A patent/EP3297661B1/en active Active
- 2016-05-16 JP JP2017556995A patent/JP6867302B2/ja active Active
- 2016-05-16 US US15/555,276 patent/US10526597B2/en active Active
- 2016-05-16 WO PCT/US2016/032660 patent/WO2016187101A2/en not_active Ceased
-
2020
- 2020-01-02 US US16/732,710 patent/US11332735B2/en active Active
-
2021
- 2021-01-07 JP JP2021001276A patent/JP7109605B2/ja active Active
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