JP2021004203A - 皮膚洗浄用スプレー剤 - Google Patents
皮膚洗浄用スプレー剤 Download PDFInfo
- Publication number
- JP2021004203A JP2021004203A JP2019118265A JP2019118265A JP2021004203A JP 2021004203 A JP2021004203 A JP 2021004203A JP 2019118265 A JP2019118265 A JP 2019118265A JP 2019118265 A JP2019118265 A JP 2019118265A JP 2021004203 A JP2021004203 A JP 2021004203A
- Authority
- JP
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- Prior art keywords
- skin
- skin cleansing
- spray
- acid
- spray agent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000007921 spray Substances 0.000 title claims abstract description 92
- 239000003795 chemical substances by application Substances 0.000 title claims abstract description 56
- 239000004094 surface-active agent Substances 0.000 claims abstract description 33
- 150000002148 esters Chemical class 0.000 claims abstract description 25
- -1 dicarboxylic acid dialkoxyalkyl ester Chemical class 0.000 claims description 27
- OFOBLEOULBTSOW-UHFFFAOYSA-N Malonic acid Chemical compound OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 claims description 20
- 238000004140 cleaning Methods 0.000 claims description 20
- 150000007949 saponins Chemical class 0.000 claims description 19
- 229930182490 saponin Natural products 0.000 claims description 18
- 235000017709 saponins Nutrition 0.000 claims description 18
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 claims description 17
- 150000005215 alkyl ethers Chemical class 0.000 claims description 15
- 108010028921 Lipopeptides Proteins 0.000 claims description 10
- 239000000787 lecithin Substances 0.000 claims description 10
- 235000010445 lecithin Nutrition 0.000 claims description 10
- 229940067606 lecithin Drugs 0.000 claims description 10
- ASWBNKHCZGQVJV-UHFFFAOYSA-N (3-hexadecanoyloxy-2-hydroxypropyl) 2-(trimethylazaniumyl)ethyl phosphate Chemical compound CCCCCCCCCCCCCCCC(=O)OCC(O)COP([O-])(=O)OCC[N+](C)(C)C ASWBNKHCZGQVJV-UHFFFAOYSA-N 0.000 claims description 9
- 150000002327 glycerophospholipids Chemical class 0.000 claims description 8
- 150000003839 salts Chemical class 0.000 claims description 8
- HQHCYKULIHKCEB-UHFFFAOYSA-N tetradecanedioic acid Chemical compound OC(=O)CCCCCCCCCCCCC(O)=O HQHCYKULIHKCEB-UHFFFAOYSA-N 0.000 claims description 8
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- 239000000443 aerosol Substances 0.000 claims description 5
- JJOJFIHJIRWASH-UHFFFAOYSA-N icosanedioic acid Chemical compound OC(=O)CCCCCCCCCCCCCCCCCCC(O)=O JJOJFIHJIRWASH-UHFFFAOYSA-N 0.000 claims description 4
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- 230000001747 exhibiting effect Effects 0.000 abstract 1
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- 206010040880 Skin irritation Diseases 0.000 description 16
- 230000036556 skin irritation Effects 0.000 description 16
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- 239000001397 quillaja saponaria molina bark Substances 0.000 description 13
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- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 5
- 239000000654 additive Substances 0.000 description 5
- 235000014113 dietary fatty acids Nutrition 0.000 description 5
- 239000000194 fatty acid Substances 0.000 description 5
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- 230000003020 moisturizing effect Effects 0.000 description 5
- 230000000144 pharmacologic effect Effects 0.000 description 5
- 150000003904 phospholipids Chemical class 0.000 description 5
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 4
- 238000002835 absorbance Methods 0.000 description 4
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- MGQKBAKCRHGMEI-UHFFFAOYSA-N bis[2-(2-ethoxyethoxy)ethyl] butanedioate Chemical compound CCOCCOCCOC(=O)CCC(=O)OCCOCCOCC MGQKBAKCRHGMEI-UHFFFAOYSA-N 0.000 description 4
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- 239000000049 pigment Substances 0.000 description 4
- CXMXRPHRNRROMY-UHFFFAOYSA-N sebacic acid Chemical compound OC(=O)CCCCCCCCC(O)=O CXMXRPHRNRROMY-UHFFFAOYSA-N 0.000 description 4
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- JQWAHKMIYCERGA-UHFFFAOYSA-N (2-nonanoyloxy-3-octadeca-9,12-dienoyloxypropoxy)-[2-(trimethylazaniumyl)ethyl]phosphinate Chemical compound CCCCCCCCC(=O)OC(COP([O-])(=O)CC[N+](C)(C)C)COC(=O)CCCCCCCC=CCC=CCCCCC JQWAHKMIYCERGA-UHFFFAOYSA-N 0.000 description 3
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 description 3
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
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- 239000012911 assay medium Substances 0.000 description 3
- KDYFGRWQOYBRFD-NUQCWPJISA-N butanedioic acid Chemical compound O[14C](=O)CC[14C](O)=O KDYFGRWQOYBRFD-NUQCWPJISA-N 0.000 description 3
- 125000004432 carbon atom Chemical group C* 0.000 description 3
- 230000000052 comparative effect Effects 0.000 description 3
- MTHSVFCYNBDYFN-UHFFFAOYSA-N diethylene glycol Chemical compound OCCOCCO MTHSVFCYNBDYFN-UHFFFAOYSA-N 0.000 description 3
- XXJWXESWEXIICW-UHFFFAOYSA-N diethylene glycol monoethyl ether Chemical compound CCOCCOCCO XXJWXESWEXIICW-UHFFFAOYSA-N 0.000 description 3
- 229940075557 diethylene glycol monoethyl ether Drugs 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 238000002347 injection Methods 0.000 description 3
- 239000007924 injection Substances 0.000 description 3
- 239000000463 material Substances 0.000 description 3
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- 239000001509 sodium citrate Substances 0.000 description 3
- 150000003408 sphingolipids Chemical class 0.000 description 3
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 2
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 description 2
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 description 2
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- PZNPLUBHRSSFHT-RRHRGVEJSA-N 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCCCC(=O)O[C@@H](COP([O-])(=O)OCC[N+](C)(C)C)COC(=O)CCCCCCCCCCCCCCC PZNPLUBHRSSFHT-RRHRGVEJSA-N 0.000 description 2
- RTBFRGCFXZNCOE-UHFFFAOYSA-N 1-methylsulfonylpiperidin-4-one Chemical compound CS(=O)(=O)N1CCC(=O)CC1 RTBFRGCFXZNCOE-UHFFFAOYSA-N 0.000 description 2
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- OSCJHTSDLYVCQC-UHFFFAOYSA-N 2-ethylhexyl 4-[[4-[4-(tert-butylcarbamoyl)anilino]-6-[4-(2-ethylhexoxycarbonyl)anilino]-1,3,5-triazin-2-yl]amino]benzoate Chemical compound C1=CC(C(=O)OCC(CC)CCCC)=CC=C1NC1=NC(NC=2C=CC(=CC=2)C(=O)NC(C)(C)C)=NC(NC=2C=CC(=CC=2)C(=O)OCC(CC)CCCC)=N1 OSCJHTSDLYVCQC-UHFFFAOYSA-N 0.000 description 2
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Abstract
Description
項1. (A)天然由来界面活性剤と(B)両親媒性エステルとを含有し、前記(A)の含有量が0.025〜2重量%であり、噴霧式容器に収容された、皮膚洗浄用スプレー剤。
項2. 前記噴霧式容器がポンプ式スプレー容器である、項1に記載の皮膚洗浄用スプレー剤。
項3. 前記噴霧式容器がエアゾール式スプレー容器である、項1に記載の皮膚洗浄用スプレー剤。
項4. 前記(A)成分が、グリセロリン脂質、サポニン、及びリポペプチドからなる群より選択される、項1〜3のいずれかに記載の皮膚洗浄用スプレー剤。
項5. 前記グリセロリン脂質が、レシチン、リゾレシチン、及び水素添加レシチンからなる群より選択される、項4に記載の皮膚洗浄用スプレー剤。
項6. 前記リポペプチドがサーファクチン及びその塩からなる群より選択される、項4に記載の皮膚洗浄用スプレー剤。
項7. 前記(B)成分が、ジカルボン酸ビス(ポリオキシアルキレンアルキルエーテル)エステル、ジカルボン酸ジアルコキシアルキルエステル、及び(エイコサン二酸/テトラデカン二酸)ポリグリセリル−10よりなる群から選ばれる、項1〜6のいずれかに記載の皮膚洗浄用スプレー剤。
項8. 前記ジカルボン酸ビス(ポリオキシアルキレンアルキルエーテル)エステルが、シクロヘキサン−1,4−ジカルボン酸ビスエトキシジグリコールである、項7に記載の皮膚洗浄用スプレー剤。
本発明の皮膚洗浄用スプレー剤は、(A)成分として天然由来界面活性剤を含有する。天然由来界面活性剤は、生物を起源とし界面活性作用を有する物質である。
本発明の皮膚洗浄用スプレー剤は、(B)成分として両親媒性エステルを含有する。(B)成分は単独で洗浄作用を示さないが、0.025〜2重量%の(A)成分と共存させることによって、低刺激性を維持しながら皮膚洗浄用スプレー剤の洗浄力を向上させることができる。
本発明の皮膚洗浄用スプレー剤には、前記成分の他に、本発明の効果を損なわない範囲で、製剤化等に必要とされる他の基剤や添加剤が含まれていてもよい。このような添加剤については、薬学的に許容されることを限度として特に制限されないが、例えば、水、炭素数1〜5の低級アルコール(エタノール、イソプロパノール等)、及び多価アルコール(エチレングリコール、1,3−ブチレングリコール(BG)、プロピレングリコール、イソプレングリコール、ジエチレングリコール、ジプロピレングリコール、ポリプロピレングリコール、グリセリン等)等の水性基剤;防腐剤(フェノキシエタノール、メチルパラベン、プロピルパラベン、安息香酸、安息香酸ナトリウム、ソルビン酸等)、着香剤(シトラール、1,8−シオネール、シトロネラール、ファルネソール等)、着色剤(タール色素(褐色201号、青色201号、黄色4号、黄色403号等)、カカオ色素、クロロフィル、酸化アルミニウム等)、粘稠剤(ヒドロキシプロピルセルロース、ヒドロキシエチルセルロース、架橋型アクリル酸重合体、カルボキシビニルポリマー、ヒプロメロース、ポリビニルピロリドン、アルギン酸ナトリウム、エチルセルロース、カルボキシメチルセルロースナトリウム、キサンタンガム、カラギーナン等)、pH調整剤(リン酸、塩酸、クエン酸、クエン酸ナトリウム(クエン酸三ナトリウム)、コハク酸、酒石酸、水酸化ナトリウム、水酸化カリウム、トリエタノールアミン、トリイソプロパノールアミン等)、湿潤剤(dl−ピロリドンカルボン酸ナトリウム液、D−ソルビトール液、マクロゴール等)、安定化剤(ジブチルヒドロキシトルエン、ブチルヒドロキシアニソール、エデト酸ナトリウム、メタリン酸ナトリウム、L−アルギニン、L−アスパラギン酸、DL−アラニン、グリシン、エリソルビン酸ナトリウム、没食子酸プロピル、亜硫酸ナトリウム、二酸化硫黄、クロロゲン酸、カテキン、ローズマリー抽出物等)、酸化防止剤、紫外線吸収剤、キレート剤、粘着剤、緩衝剤、溶解補助剤、可溶化剤、保存剤等の添加剤が挙げられる。これらの基材や添加剤は、1種単独で使用してもよく、また2種以上を組み合わせて使用してもよい。これらの基材や添加剤の含有量は、製剤形態等に応じて適宜設定することができる。
本発明の皮膚洗浄用スプレー剤の形態は、常温で液状又はジェル状である。また、本発明の皮膚洗浄用スプレー剤の粘度としては、20℃において10000mPa・s以下、好ましくは5000mPa・s以下が挙げられる。なお、粘度は、BL粘度計(ロ−ターNo3、6rpm、20℃)によって測定される値である。
本発明の皮膚洗浄用スプレー剤を収容する容器については、噴霧式容器であることを限度として特に限定されない。なお、本発明における噴霧式容器は、内容物をミスト状態で吐出するものであり、皮膚洗浄剤組成物を泡状態で吐出するポンプフォーマー容器とは異なる。
本発明の皮膚洗浄用スプレー剤は、皮膚の油脂、汗などの体液や汚れ等を除去するために用いられるものであり、化粧落とし(クレンジング)として用いられるものではない。本発明の皮膚洗浄用スプレー剤は、水で薄めることなく、泡立てずにそのまま皮膚に塗布することで使用する。1回当たりの使用量としては、界面活性剤の濃度及び汚れの程度等にもよるが、例えば洗顔に用いる場合0.5〜3g、好ましくは1〜2gが挙げられる。
本発明の皮膚洗浄用スプレー剤は、前述する(A)成分及び(B)成分、並びに必要に応じて配合される他の成分等を混合して、所定の形態に調製された後、噴霧式容器に収容されることによって製造される。噴霧式容器としてエアゾール式スプレー容器に収容される場合は、ガス等の噴霧剤と共に収容されて製造される。
表1〜4に示す組成の皮膚洗浄用スプレー剤を調製した。表1〜4に示す各成分の詳細は以下の通りである。なお、表1〜4に示す皮膚洗浄用スプレー剤は液状であり、20℃における粘度(BL粘度計(ブルックフィールド社製B型粘度計)ロ−ターNo3、6rpmによって測定)は、いずれも5000mPa・s以下の範囲にあった。
・リゾレシチン:リゾレシチン協和(協和発酵バイオ製)
・レシチン:ベイシス LP-20(日清オイリオ製)
・水素添加レシチン:ベイシス LP-20H(日清オイリオ製)
・サポニン:ソープナッツエキスパウダー(一丸ファルコス製)(サポニン含量20重量%)
・サーファクチンナトリウム:カネカ・サーファクチン(カネカ製)
・シクロヘキサン−1,4−ジカルボン酸ビスエトキシジグリコール(日本精化株式会社製「Neosolue−Aqulio(商品名)」)
・コハク酸ビスエトキシジグリコール(高級アルコール工業株式会社製「ハイアクオスター DCS(商品名)」)
調製した皮膚洗浄用スプレー剤について、化粧品評価専門パネラー10名が洗浄力評価を行った。具体的には、各皮膚洗浄用スプレー剤をポンプ式スプレー容器(竹本容器株式会社製「Z−155−C110(商品名)」1プッシュあたりの噴射量は0.15g)に収容し、1.5gを顔に直接的に噴霧することで塗布した。5秒程度放置し、その後、手が顔に触れないように水で洗い流した。タオルで顔を抑えて水を吸い取った後、肌の汚れ落ち感を以下の指標に基づいて官能評価することで採点した。
4点:汚れ落ちが感じられた
3点:どちらでもない
2点:汚れ落ちがあまり感じられない
1点:汚れ落ちが全く感じられない
◎:45点以上
○:40点以上45点未満
△:35点以上40点未満
×:35点未満
調製した皮膚洗浄用スプレー剤について、化粧品評価専門パネラー10名がつっぱり感評価を行った。具体的には、各皮膚洗浄用スプレー剤をポンプ式スプレー容器(竹本容器株式会社製「Z−155−C110(商品名)」(1プッシュあたりの噴射量は0.15g)に収容し、1.5gを顔に直接的に噴霧することで塗布した。5秒程度放置し、その後、手が顔に触れないように水で洗い流した。タオルで顔を抑えて水を吸い取った後、つっぱり感を以下の指標に基づいて官能評価することで採点した。つっぱり感の程度が強いほど、保湿が不足していることを表している。
4点:つっぱり感をほとんど感じない
3点:つっぱり感をわずかしか感じない
2点:つっぱり感を感じる
1点:つっぱり感を強く感じる
◎:45点以上
○:40点以上45点未満
△:35点以上40点未満
×:35点未満
調製した皮膚洗浄用スプレー剤について、以下の通りに培養表皮皮膚刺激試験を行った。
1.培養表皮モデルLabCyte EPI−MODEL24の準備
アッセイ培地を温め、24ウェルアッセイプレートに0.5mLずつ添加した。培養表皮モデルLabCyte EPI−MODEL24(ロット番号:LCE24−180226−A)を、アッセイ培地を添加した24ウェルアッセイプレートに移した。培養カップ底面に気泡が無いことを確認し、CO2インキュベーターに入れ被験物質暴露まで1時間以上静置した。
表皮モデル24個のうち、12個を使用した(残りは本試験まで前培養を続けた)。24ウェルアッセイプレートをCO2インキュベーターから取り出した。アッセイ培地を温め、24ウェルアッセイプレート第3行に1.0mLずつ添加した。被験物質(各皮膚洗浄用スプレー剤)をポンプ式スプレー容器を用いずに培養カップの培養表皮に25μL滴下し、全体にいきわたらせて暴露した。暴露後1分、5分、10分経過時に被験物質を吸引除去し、カップ内の培養表皮モデルをリン酸緩衝液(PBS)で洗浄し、24ウェルアッセイプレート第3行に移した。
MTT試験は、細胞内に取り込まれたMTT[3−(4,5−dimethylthiazol−2−yl)−2,5−diphenyltetrazolium bromi
de]が細胞内にあるミトコンドリアの脱水素酵素によって還元されて生じるフォルマザン色素を、有機溶媒により抽出して570nmの吸光度を測定することで生細胞率を計測する方法である。
◎:90%以上
○:75%以上90%未満
△:65%以上75%未満
×:50%以上65%未満
××:50%未満
Claims (8)
- (A)天然由来界面活性剤と(B)両親媒性エステルとを含有し、前記(A)の含有量が0.025〜2重量%であり、噴霧式容器に収容された、皮膚洗浄用スプレー剤。
- 前記噴霧式容器がポンプ式スプレー容器である、請求項1に記載の皮膚洗浄用スプレー剤。
- 前記噴霧式容器がエアゾール式スプレー容器である、請求項1に記載の皮膚洗浄用スプレー剤。
- 前記(A)成分が、グリセロリン脂質、サポニン、及びリポペプチドからなる群より選択される、請求項1〜3のいずれかに記載の皮膚洗浄用スプレー剤。
- 前記グリセロリン脂質が、レシチン、リゾレシチン、及び水素添加レシチンからなる群より選択される、請求項4に記載の皮膚洗浄用スプレー剤。
- 前記リポペプチドがサーファクチン及びその塩からなる群より選択される、請求項4に記載の皮膚洗浄用スプレー剤。
- 前記(B)成分が、ジカルボン酸ビス(ポリオキシアルキレンアルキルエーテル)エステル、ジカルボン酸ジアルコキシアルキルエステル、及び(エイコサン二酸/テトラデカン二酸)ポリグリセリル−10よりなる群から選ばれる、請求項1〜6のいずれかに記載の皮膚洗浄用スプレー剤。
- 前記ジカルボン酸ビス(ポリオキシアルキレンアルキルエーテル)エステルが、シクロヘキサン−1,4−ジカルボン酸ビスエトキシジグリコールである、請求項7に記載の皮膚洗浄用スプレー剤。
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A911 | Transfer to examiner for re-examination before appeal (zenchi) |
Free format text: JAPANESE INTERMEDIATE CODE: A911 Effective date: 20231019 |
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A912 | Re-examination (zenchi) completed and case transferred to appeal board |
Free format text: JAPANESE INTERMEDIATE CODE: A912 Effective date: 20231201 |