CN112367965A - 皮肤清洗用喷雾剂 - Google Patents
皮肤清洗用喷雾剂 Download PDFInfo
- Publication number
- CN112367965A CN112367965A CN202080003388.4A CN202080003388A CN112367965A CN 112367965 A CN112367965 A CN 112367965A CN 202080003388 A CN202080003388 A CN 202080003388A CN 112367965 A CN112367965 A CN 112367965A
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- Prior art keywords
- skin
- spray
- cleansing
- skin cleansing
- acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Abstract
本发明的目的在于提供一种以与以往不同的方法使用的皮肤清洗料组合物。一种皮肤清洗用喷雾剂,其含有(A)来源于天然的表面活性剂和(B)两亲性酯,上述(A)的含量为0.025~2重量%,且收纳于喷雾式容器中,上述皮肤清洗用喷雾剂能够在减少皮肤清洗料组合物的皮肤刺激性的同时发挥优异的清洗力,因此能够提供与在应用于肌肤时预先起泡的以往的用途不同的、将皮肤清洗料组合物向肌肤直接喷雾进行应用这样的新用途。
Description
技术领域
本发明涉及直接向肌肤喷雾而使用的皮肤清洗用喷雾剂。
背景技术
作为以清洗皮肤、保持肌肤清洁为目的的制品,提供有洗面奶、体皂、洗发水等各种皮肤清洗料组合物。在皮肤清洗料组合物对皮肤进行清洗的机制中,表面活性剂吸附到污垢上而使污垢与水之间的表面张力变小,因摩擦而产生的机械力也相互作用,使污垢在水中浮起。为了使这样的清洗机制有效地发挥作用,需要以临界胶束浓度以上配合表面活性剂。
另一方面,由于表面活性剂产生的清洗力过强而成为皮肤刺激的原因,其结果,还存在会引起以干燥肌肤为代表的肌肤问题这样的现状。因此,以使对肌肤的作用温和化为目的,提出了各种研究清洗成分的组合、配合量等的配方。其中,由于认识到清洗时形成的泡沫能减轻肌肤与手指直接接触而产生的摩擦,因此提高起泡力、泡沫保持力等泡沫质量的配方作为使对皮肤的作用温和的配方而优异是一般常识。
因此,近年来,提出了各种泵起泡器类型的皮肤清洗料,不仅能简单地得到优质的泡沫,而且对肌肤的柔和性也受到关注。具体而言,专利文献1中公开了一种液体皮肤清洗剂制品,其由起泡容器(日语原文:フォーマー容器)和填充于该起泡容器而成的液体皮肤清洗剂组合物构成,上述液体皮肤清洗剂组合物含有(A)具有碳原子数7~21的直链或支链的一价烃基的特定的脂肪酸盐3~10质量%、(B)特定的氯化二甲基二烯丙基铵与丙烯酸和/或丙烯酰胺的共聚物、以及(C)糖醇,(A)成分的含量与(B)成分的含量的质量比(A)/(B)为20~250。此外,专利文献2中公开了一种皮肤清洗剂组合物,其特征在于,上述皮肤清洗剂组合物是将清洗剂填充于起泡容器而成的,上述清洗剂含有(a)脂肪酸盐2~9质量%、(b)月桂基二甲基氨基乙酸甜菜碱0.5~4质量%和(c)二元醇的一种或两种以上1~10质量%,且(a)成分与(b)成分的配合量(质量%)的和(a)+(b)为3~10质量%,配合量比(b)/(a)为0.1~0.5。进而,专利文献3中公开了一种清洗料组合物,上述清洗料组合物含有(a)月桂基二甲基氨基乙酸甜菜碱和(b)由碳原子数5~25的脂肪酸形成且特定组成的高级脂肪酸肥皂4~15质量%,且由起泡容器喷出。
另一方面,还已知有考虑环境负荷而使用具有生物降解性的天然表面活性剂的清洗剂组合物。例如,专利文献4中公开了一种清洗剂组合物,其中,天然表面活性剂11~45重量份、芒硝25~35重量份、硬水软化剂10~40重量份、螯合剂0.1~5重量份、和余量的附加清洗剂原料合计为100重量份。
现有技术文献
专利文献
专利文献1:国际公开第2014/003114号
专利文献2:日本特开2016-098182号公报
专利文献3:国际公开第2017/081897号
专利文献4:日本特开2014-051544号公报
发明内容
发明要解决的课题
泵起泡器类型的皮肤清洗料组合物的表面活性剂的配合量比较少,从这一点考虑,认为存在对皮肤的刺激与固体状、半固体状的皮肤清洗料组合物相比减少的趋势。另一方面,泵起泡器类型的皮肤清洗料组合物以呈泡的状态喷出为大前提,因此在其构成上不可避免地配合为了发挥起泡力而需要的最低限度的表面活性剂。
此外,除了以卸妆(cleansing)为目的的皮肤清洗料以外,创造出了各种以除去皮脂或汗等体液、污垢等为目的的皮肤清洗料,但包括泵起泡器类型的皮肤清洗料和含有天然表面活性剂的皮肤清洗料在内,哪个皮肤清洗料也不例外,以在应用于肌肤之前起泡为前提,此外,从缓和对肌肤的摩擦这一点考虑,优选在清洗前很好地起泡也是常识。虽然泡沫通过介于肌肤与手之间而能够缓和物理性的摩擦,但由于泡沫自身与肌肤摩擦,因此其自身产生物理摩擦,从而成为对肌肤的刺激,这一点没有变化。如此,在与以往同样的使用方法中,皮肤清洗料对肌肤的负担的减轻是有限的。
因此,本发明的目的在于提供一种以与以往不同的方法使用的皮肤清洗料组合物。
用于解决课题的技术方案
本发明人为了进一步减轻对肌肤的刺激,想到了在应用于肌肤时不预先起泡地将皮肤清洗料组合物向肌肤直接喷雾进行应用这样的崭新的用途。此外,发现为了进一步减轻对肌肤的刺激,配合来源于天然的表面活性剂,使其配合量比以往的皮肤清洗料组合物所含的配合量大幅减少。在仅含有如此少量的表面活性剂的皮肤清洗料组合物中,对肌肤的刺激减少的代价是无法得到清洗力,但通过同时含有两亲性酯,即使不预先起泡也有效地得到清洗力。本发明是通过基于该发现进一步反复研究而完成的。
即,本发明提供以下公开的方式的发明。
项1.一种皮肤清洗用喷雾剂,其含有(A)来源于天然的表面活性剂和(B)两亲性酯,所述(A)的含量为0.025~2重量%,所述皮肤清洗用喷雾剂收纳于喷雾式容器中。
项2.根据项1所述的皮肤清洗用喷雾剂,其中,所述喷雾式容器为泵式喷雾容器。
项3.根据项1所述的皮肤清洗用喷雾剂,其中,所述喷雾式容器为气溶胶式喷雾容器。
项4.根据项1~3中任一项所述的皮肤清洗用喷雾剂,其中,所述(A)成分选自由甘油磷脂、皂苷和脂肽组成的组。
项5.根据项4所述的皮肤清洗用喷雾剂,其中,所述甘油磷脂选自由卵磷脂、溶血卵磷脂和氢化卵磷脂组成的组。
项6.根据项4所述的皮肤清洗用喷雾剂,其中,所述脂肽选自由枯草菌脂肽(surfactin)及其盐组成的组。
项7、根据项1~6中任一项所述的皮肤清洗用喷雾剂,其中,所述(B)成分选自由二羧酸双(聚氧化烯烷基醚)酯、二羧酸二烷氧基烷基酯和聚甘油-10二十碳二酸酯/十四碳二酸酯组成的组。
项8、根据项7所述的皮肤清洗用喷雾剂,其中,所述二羧酸双(聚氧化烯烷基醚)酯为双-二乙氧基二甘醇环己烷1,4-二羧酸酯。
发明效果
根据本发明,能够在减少皮肤清洗料组合物的皮肤刺激性的同时发挥优异的清洗力,因此能够提供与在应用于肌肤时预先起泡的以往的用途不同的、向肌肤直接喷雾皮肤清洗料组合物进行应用这样的新用途。由于以不预先起泡的方式进行清洗,因此能够使皮肤清洗用液体组合物中的表面活性剂的配合量与以往的皮肤清洗用液体组合物所含的配合量相比大幅减少,由此也能够更进一步减少皮肤刺激性。
具体实施方式
本发明的皮肤清洗用喷雾剂的特征在于,其含有规定量的(A)来源于天然的表面活性剂(以下,有时记载为(A)成分)和(B)两亲性酯(以下,有时记载为(B)成分),且收纳于喷雾式容器中。以下,对本发明的皮肤清洗用喷雾剂进行详述。
(A)来源于天然的表面活性剂
本发明的皮肤清洗用喷雾剂含有来源于天然的表面活性剂作为(A)成分。来源于天然的表面活性剂是以生物为起源且具有表面活性作用的物质。
作为本发明中使用的来源于天然的表面活性剂,没有特别限定,可举出从动物、植物或微生物提取和纯化的天然物;对这些天然物进行微生物学培养合成而成的物质、进行基因工程学合成而成的物质、和进行化学合成而成的物质;对这些天然物进行了氢化处理、羟基化处理、水解处理等处理而成的物质等。
作为本发明中使用的来源于天然的表面活性剂的例子,可举出磷脂质、皂苷、脂肽、胆固醇、胆汁酸等。这些来源于天然的表面活性剂可以单独使用一种,也可以组合使用两种以上。这些来源于天然的表面活性剂中,优选可举出磷脂质、皂苷、脂肽。
作为磷脂质,可举出甘油磷脂、鞘磷脂等。甘油磷脂是具有甘油磷酸骨架的物质,是具有脂肪酸酯、长链烷基醚、乙烯基醚等作为亲油基的物质。作为甘油磷脂的具体例,可举出磷脂酰胆碱(卵磷脂)、磷脂酰乙醇胺、磷脂酰丝氨酸、磷酯酰肌醇、磷脂酰肌醇聚磷酸、二磷脂酰甘油(心磷脂)、磷脂酸、以及它们的氢化处理物、羟基化处理物和水解处理物。鞘磷脂是鞘氨醇、植物鞘氨醇等长链碱或长链脂肪酸的磷酸或膦酸衍生物。作为鞘磷脂的具体例,可举出神经酰胺-1-磷酸衍生物(神经鞘磷脂等)、神经酰胺1-膦酸衍生物(神经酰胺氨基乙基膦酸等)。这些磷脂质可以单独使用一种,也可以组合使用两种以上。
这些磷脂质中,优选可举出甘油磷脂,更优选可举出卵磷脂(大豆卵磷脂、蛋黄卵磷脂)、氢化卵磷脂、羟基化卵磷脂、溶血卵磷脂,进一步优选可举出卵磷脂(大豆卵磷脂、蛋黄卵磷脂等)、氢化卵磷脂、溶血卵磷脂。此外,从得到更加优异的清洗力的观点出发,优选可举出卵磷脂(大豆卵磷脂、蛋黄卵磷脂等)和溶血卵磷脂,从进一步抑制因皮肤刺激性和保湿不足所致的紧绷感的观点出发,优选可举出氢化卵磷脂。
皂苷是由皂角苷配基和糖构成的配糖体,具体而言,可举出三萜的配糖体和类固醇的配糖体。作为皂苷的具体例,可举出皂树皂苷、大豆皂苷、丝兰皂甙、槐树皂苷、甜菜皂苷、赤豆皂甙、人参皂苷、茶皂苷、丝瓜皂苷、积雪草皂苷等。这些皂苷可以单独使用一种,也可以组合使用两种以上。
脂肽是经脂质化的肽,具体而言,可举出枯草菌脂肽、节活性素、伊枯草菌素和它们的盐等。这些脂肽可以单独使用一种,也可以组合使用两种以上。
这些脂肽中,优选可举出枯草菌脂肽及其盐,更优选可举出枯草菌脂肽的盐。枯草菌脂肽的盐是由下述式(I)表示的化合物。
【化学式1】
式(I)中,X表示选自亮氨酸、异亮氨酸和缬氨酸中的氨基酸残基,R表示C9-18烷基,M+表示碱金属离子或季铵离子。作为碱金属离子,没有特别限定,可举出锂离子、钠离子、钾离子等,优选可举出钠离子。作为季铵离子的取代基,例如,可举出甲基、乙基、正丙基、异丙基、正丁基、叔丁基等烷基;苄基、甲基苄基、苯基乙基等芳烷基;苯基、甲苯基、二甲苯基等芳基等有机基团。这些枯草菌脂肽或其盐可以单独使用一种,也可以组合使用两种以上。
本发明的皮肤清洗用喷雾剂中的(A)成分的含量为0.025~2重量%。通过使表面活性剂量为如此少量,能够显著降低皮肤刺激性。本发明中,通过使(B)成分共存,能够发挥优异的清洗力,因此即使是原本无法发挥有效的清洗力的少量的表面活性剂量也能够有效地发挥清洗力。
作为(A)成分的优选含量,例如,从得到更加优异的清洗力的观点出发,可举出0.5~2重量%、更优选1~2重量%,从进一步抑制因保湿不足所致的紧绷感的观点出发,可举出0.025~1.5重量%、更优选0.025~1重量%。进而,在(A)成分为卵磷脂或溶血卵磷脂的情况下,从得到更加优异的清洗力的观点出发,可举出0.5~2重量%,从进一步抑制因保湿不足所致的紧绷感的观点出发,可举出0.025~1重量%,从进一步抑制皮肤刺激性的观点出发,可举出0.025~1.5重量%。在(A)成分为皂苷的情况下,从得到更加优异的清洗力的观点出发,可举出1~2重量%。
(B)两亲性酯
本发明的皮肤清洗用喷雾剂含有两亲性酯作为(B)成分。(B)成分在单独使用时不显现清洗作用,通过使其与0.025~2重量%的(A)成分共存,能够在维持低刺激性的同时提高皮肤清洗用喷雾剂的清洗力。
本发明中,两亲性酯在基于日本药典一般试验法所规定的方法的测定中,在将电导率调整为70~110μs/m的离子交换水中在常温下溶解2质量%以上,且在常温(25℃)下在作为油剂的异壬酸异十三烷基酯(日清奥利友集团公司制,SALACOS 913)中也溶解10质量%以上,且不包括酯系表面活性剂。
作为两亲性酯,没有特别限定,从更良好地得到皮肤刺激降低性和清洗力的观点出发,优选选自由二羧酸双(聚氧化烯烷基醚)酯、二羧酸二烷氧基烷基酯和聚甘油-10二十碳二酸酯/十四碳二酸酯组成的组的两亲性酯。作为两亲性酯,可以单独使用二羧酸双(聚氧化烯烷基醚)酯、二羧酸二烷氧基烷基酯、和聚甘油-10二十碳二酸酯/十四碳二酸酯中的任一者,此外,也可以组合使用两种以上。这些两亲性酯中,从进一步抑制因保湿不足所致的紧绷感的观点出发,更优选为二羧酸双(聚氧化烯烷基醚)酯。
本发明中使用的二羧酸双(聚氧化烯烷基醚)酯是二羧酸与聚氧化烯烷基醚的二酯化合物。作为构成二羧酸双(聚氧化烯烷基醚)酯这样的二酯化合物的二羧酸的具体例,例如,可举出草酸、丙二酸、琥珀酸、酒石酸、苹果酸、戊二酸、己二酸、庚二酸、辛二酸、壬二酸、癸二酸、天冬氨酸、谷氨酸、丙酮二羧酸、邻苯二甲酸、环己烷-1,4-二羧酸等。此外,作为构成二酯化合物的聚氧化烯烷基醚,例如可举出聚氧乙烯单烷基醚等,更具体而言,例如可举出二乙二醇单乙基醚、三乙二醇单乙基醚等。
这些二羧酸双(聚氧化烯烷基醚)酯中,从更良好地得到皮肤刺激降低性和清洗力的观点出发,优选可举出环己烷-1,4-二羧酸与二乙二醇单乙基醚的二酯化合物、具体而言以INCI名(International Cosmetic Ingredient Dictionary and Handbook,第13版,第1卷,CTFA,2010年,p.331):BIS-ETHOXYDIGLYCOL CYCLOHEXANE 1,4-DICARBOXYLATE表述的被称为双-二乙氧基二甘醇环己烷1,4-二羧酸酯的化合物、以及琥珀酸与二乙二醇单乙基醚的二酯化合物、具体而言以INCI名(International Cosmetic Ingredient Dictionaryand Handbook,第13版,第1卷,CTFA,2010年,p.331-332):BIS-ETHOXYDIGLYCOL SUCCINATE表述的被称为双乙氧基二甘醇琥珀酸酯的化合物。
此外,本发明中,作为上述双-二乙氧基二甘醇环己烷1,4-二羧酸酯的具体例,例如,可举出日本精化株式会社制的“Neosolue-Aqulio(商品名)”等。此外,作为上述双乙氧基二甘醇琥珀酸酯的具体例,例如,可举出高级醇工业株式会社制的“HAIAQUEOUSTER DCS(商品名)”等。
这些二羧酸双(聚氧化烯烷基醚)酯可以单独使用一种,也可以组合使用两种以上。
这些二羧酸双(聚氧化烯烷基醚)酯中,特别是在使用氢化卵磷脂或脂肽作为(A)成分的情况下,从进一步抑制因保湿不足所致的紧绷感的观点出发,优选使用双-二乙氧基二甘醇环己烷1,4-二羧酸酯。
本发明中使用的二羧酸二烷氧基烷基酯是二羧酸与烷氧基醇的二酯化合物。作为构成二羧酸二烷氧基烷基酯这样的二酯化合物的二羧酸的具体例,例如可举出草酸、丙二酸、琥珀酸、酒石酸、苹果酸、戊二酸、己二酸、庚二酸、辛二酸、壬二酸、癸二酸、天冬氨酸、谷氨酸、丙酮二羧酸、邻苯二甲酸、环己烷-1,4-二羧酸等。此外,作为构成二酯化合物的烷氧基醇,例如可举出2-甲氧基乙醇、2-乙氧基乙醇等。
这些二羧酸二烷氧基烷基酯中,从更良好地得到皮肤刺激降低性和清洗力的观点出发,优选可举出琥珀酸与2-乙氧基乙醇的二酯化合物,具体而言,可举出琥珀酸二乙氧基乙酯。
这些二羧酸二烷氧基烷基酯,可以单独使用一种,此外可以组合使用两种以上。
作为本发明中使用的聚甘油-10二十碳二酸酯/十四碳二酸酯,没有特别限定,例如,可举出日本精化株式会社制的“Neosolue-Aqua(商品名)”、“Neosolue-AquaS(商品名)”等。
作为本发明的皮肤清洗用喷雾剂中的(B)成分的含量,没有特别限定,例如可举出0.1重量%以上。从更加良好地得到清洗力的观点、和/或进一步降低因保湿不足所致的紧绷感的观点出发,作为(B)成分的含量,可举出优选0.5重量%以上、更优选1.5重量%以上、更优选2重量%以上。(B)成分的含量的范围的上限没有特别限定,从皮肤清洗用喷雾剂的稳定性等的观点出发,例如可举出5重量%以下、优选为4重量%以下、更优选为3重量%以下。
在本发明的皮肤清洗用喷雾剂中,(A)成分与(B)成分的比率没有特别限定,由上述的各含量决定,从更良好地得到皮肤刺激降低性和清洗力的观点出发,相对于(A)成分1重量份,可举出(B)成分例如为0.1~100重量份、优选1~80重量份。此外,从得到更加优异的清洗力的观点出发,相对于(A)成分1重量份,可举出(B)成分为1~4重量份、更优选1~2重量份,从进一步抑制因保湿不足所致的紧绷感的观点出发,可举出1.2~80重量份、更优选2~80重量份。进而,在(A)成分为卵磷脂或溶血卵磷脂的情况下,从得到更加优异的清洗力的观点出发,相对于(A)成分1重量份,可举出(B)成分为1~4重量份,从进一步抑制因保湿不足所致的紧绷感的观点出发,相对于(A)成分1重量份,可举出(B)成分为2~80重量份,从进一步抑制皮肤刺激性的观点出发,相对于(A)成分1重量份,可举出(B)成分为1.2~80重量份。在(A)成分为皂苷的情况下,从得到更加优异的清洗力的观点出发,相对于(A)成分1重量份,可举出(B)成分为1~2重量份。
其他成分
本发明的皮肤清洗用喷雾剂中,除了上述成分以外,在不损害本发明的效果的范围内,也可以含有制剂化等所需的其它的基剂、添加剂。对于这样的添加剂,只要在药学上可接受则没有特别限制,例如可举出水、碳原子数1~5的低级醇(乙醇、异丙醇等)和多元醇(乙二醇、1,3-丁二醇(1,3-BG)、丙二醇、异戊二醇、二乙二醇、二丙二醇、聚丙二醇、甘油等)等水性基剂;防腐剂(苯氧基乙醇、对羟基苯甲酸甲酯、对羟基苯甲酸丙酯、苯甲酸、苯甲酸钠、山梨酸等)、着香剂(柠檬醛、1,8-桉树脑、香茅醛、法呢醇等)、着色剂(焦油色素(褐色201号、蓝色201号、黄色4号、黄色403号等)、可可色素、叶绿素、氧化铝等)、粘稠剂(羟基丙基纤维素、羟基乙基纤维素、交联型丙烯酸聚合物、羧基乙烯基聚合物、羟丙基甲基纤维素、聚乙烯基吡咯烷酮、海藻酸钠、乙基纤维素、羧基甲基纤维素钠、黄原胶、卡拉胶等)、pH调节剂(磷酸、盐酸、柠檬酸、柠檬酸钠(柠檬酸三钠)、琥珀酸、酒石酸、氢氧化钠、氢氧化钾、三乙醇胺、三异丙醇胺等)、湿润剂(dl-吡咯烷酮羧酸钠液、D-山梨糖醇溶液、聚乙二醇(MACROGOL)等)、稳定剂(二丁基羟基甲苯、丁基羟基苯甲醚、乙二胺四乙酸钠、偏磷酸钠、L-精氨酸、L-天冬氨酸、DL-丙氨酸、甘氨酸、异抗坏血酸钠、棓酸丙酯、亚硫酸钠、二氧化硫、绿原酸、儿茶素、迷迭香提取物等)、抗氧化剂、紫外线吸收剂、螯合剂、粘合剂、缓冲剂、溶解辅助剂、增溶剂、保存剂等添加剂。这些基材、添加剂可以单独使用一种,也可以组合使用两种以上。这些基材、添加剂的含量可以根据制剂形态等适当设定。
本发明的皮肤清洗用喷雾剂中,除了上述成分以外,在不损害本发明的效果的范围内,也可以根据需要含有其它药理成分。作为这样的药理成分,例如,可举出维生素类(维生素A类、维生素B1类、维生素B2类、维生素B5类、维生素B6类、维生素B12类、维生素C类、维生素D类、维生素K类、烟酸类、叶酸、生物素、番茄红素等)、抗组胺剂(苯海拉明、盐酸苯海拉明等)、局部麻醉剂(普鲁卡因、丁卡因、布比卡因、甲哌卡因、氯普鲁卡因、丙美卡因、美普卡因或它们的盐、奥索卡因、奥昔卡因、氧代聚乙氧基癸烷(oxypolyenthoxydecane)(日文原文:オキシポリエントキシデカン)、莨菪液、地布卡因粉末(日文原文:ペルカミンパーゼ))、聚氧乙烯月桂醚(日文原文:テシットデシチン)等)、抗炎症剂(消炎痛、联苯乙酸、双氯芬酸钠、洛索洛芬钠等)、皮肤保护剂(胶棉、蓖麻油等)、血行促进成分(壬酸香草基酰胺、烟酸苄酯、辣椒素、辣椒提取物等)、清凉剂(薄荷醇、樟脑、龙脑、薄荷水、薄荷油等)、粘多糖类(硫酸软骨素钠、葡糖胺、透明质酸、阳离子化透明质酸(二羟基丙基三甲基氯化铵透明质酸(日文原文:ヒアルロン酸ジヒドロキシプロピルトリモニウム)等)等)等。这些药理成分可以单独使用一种,也可以组合使用两种以上。在含有这些药理成分的情况下,对于其含量,只要根据所使用的药理成分的种类、所期待的效果等适当设定即可。
形态
本发明的皮肤清洗用喷雾剂的形态为,在常温下为液状或凝胶状。此外,作为本发明的皮肤清洗用喷雾剂的粘度,可举出在20℃下为10000mPa·s以下,优选为5000mPa·s以下。应予说明,粘度是利用BL粘度计(转子No3,6rpm,20℃)测定而得的值。
容器
本发明的收纳皮肤清洗用喷雾剂的容器只要为喷雾式容器,则没有特别限定。应予说明,本发明中的喷雾式容器以雾状态喷出内容物,与以泡沫状态喷出皮肤清洗剂组合物的泵起泡容器不同。
本发明中,通过如此将皮肤清洗用喷雾剂收纳于喷雾式容器,在应用于肌肤之前不起泡地将皮肤清洗用喷雾剂通过喷雾而直接涂布于肌肤。因此,对皮肤的涂布简单且能够避免涂布时由手等引起的物理摩擦。作为喷雾式容器,可举出作为非气溶胶式喷雾容器的泵式喷雾容器、和气溶胶式喷雾容器。作为喷雾式容器的口径(喷嘴内径),例如可举出优选作为在喷雾式容器为泵式喷雾容器的情况下的每1次按压的喷射量,例如可举出0.05~1.2g、优选0.1~0.3g。
用途
本发明的皮肤清洗用喷雾剂是为了除去皮肤的油脂、汗等体液、污垢等而使用的,并不是作为卸妆液(卸妆乳)使用的。本发明的皮肤清洗用喷雾剂不用水稀释、不进行起泡而直接涂布于皮肤来使用。作为每1次的使用量,也取决于表面活性剂的浓度和污垢的程度等,例如在用于洗脸的情况下可举出0.5~3g、优选为1~2g。
更具体而言,能够不用将皮肤清洗用喷雾剂取用到手上而直接从喷雾式容器通过喷雾对清洗对象部位进行涂布。如此,通过对清洗对象部位直接涂布皮肤清洗用喷雾剂,能够完全不施加清洗对象部位的皮肤与手之间产生的摩擦、清洗部位的皮肤与气泡之间产生的摩擦这样的物理摩擦,仅利用液流的机械力进行清洗。本发明的皮肤清洗用喷雾剂是清洗力优异的配方,因此通过这样不施加物理摩擦而利用液流的机械力进行清洗,能实现能显著减轻清洗时的对肌肤的负担的极其优异的清洗方法。这样不起泡的清洗方法能够迅速地进行清洗,也容易实际感受到表面活性剂少、对肌肤柔和的情况,也容易得到追求柔和地清洗肌肤的意识高的消费者的满足感。应予说明,本发明的皮肤清洗用喷雾剂特别适合于如前述那样对肌肤不施加物理摩擦的清洗方法,但并不排除将皮肤清洗用喷雾剂涂布于清洗对象部位后使用手等进行搓洗的使用方法。
作为本发明的皮肤清洗用喷雾剂的清洗对象部位,由于可清洗所有身体部位,因此没有特别限制,例如,可举出手、头发、头皮、身体、脸等。由于本发明的皮肤清洗用喷雾剂通过喷雾涂布于清洗对象部位,因此,从涂布容易性的观点出发,适合用于头发、头皮、身体。此外,本发明的皮肤清洗用喷雾剂能够以不预先起泡的方式发挥优异的清洗力,因此适合用于对刺激敏感的脸。
清洗后,皮肤清洗用喷雾剂可以用水冲洗。在用水冲洗的情况下,只要与通常的洗脸同样地进行即可,但从减轻对肌肤的负担的观点出发,优选利用水流的机械力来冲洗,以不施加由手引起的摩擦。
此外,本发明的皮肤清洗用喷雾剂由于能够使表面活性剂浓度极低,因此在该情况下,在清洗后也可以不进行冲洗。因此,本发明的皮肤清洗用喷雾剂也适合于医院中的擦拭用途、美容沙龙或美容院中的洗脸等皮肤清洗实施用途和灾害用品用途等。在不进行冲洗的情况下,也可以使用毛巾、纸巾等吸水性基材吸取并除去残留于清洗部位的皮肤清洗用喷雾剂。
制造方法
本发明的皮肤清洗用喷雾剂通过将前述的(A)成分和(B)成分、以及根据需要配合的其他成分等混合并制备成规定的形态后,收纳于喷雾式容器而制造。在收纳于作为喷雾式容器的气溶胶式喷雾容器的情况下,与气体等喷雾剂一起收纳而制造。
实施例
以下,示出实施例进一步具体地说明本发明,但本发明不限定于这些实施例。
试验例
制备表1~4所示的组成的皮肤清洗用喷雾剂。表1~4所示的各成分的详细内容如下所述。应予说明,表1~4所示的皮肤清洗用喷雾剂为液状,20℃下的粘度(由BL粘度计(Brookfield公司制B型粘度计)转子No3,6rpm测定)均为5000mPa·s以下的范围。
·溶血卵磷脂:Lysolecithin KYOWA(リゾレシチン協和)(协和发酵生物制)
·卵磷脂:BASIS LP-20(日清奥利友制)
·氢化卵磷脂:BASIS LP-20H(日清奥利友制)
·皂苷:无患子提取物粉末(一丸自然美健制)(皂苷含量20重量%)
·枯草菌脂肽钠:KANEKA Surfactin(KANEKA制)
·双-二乙氧基二甘醇环己烷1,4-二羧酸酯(日本精化株式会社制的“Neosolue-Aqulio(商品名)”)
·双乙氧基二甘醇琥珀酸酯(高级醇工业株式会社制的“HAIAQUEOUSTER DCS(商品名)”)
<清洗力评价>
对于所制备的皮肤清洗用喷雾剂,化妆品评价专门小组成员10名进行了清洗力评价。具体而言,将各皮肤清洗用喷雾剂收纳于泵式喷雾容器(竹本容器株式会社制的“Z-155-C110(商品名)”,每1次按压的喷射量为0.15g)中,通过向脸直接喷雾1.5g而进行涂布。放置5秒左右,其后,以手不接触脸的方式用水冲洗。用毛巾按压脸并吸取水后,基于以下的指标对肌肤的污垢脱落感进行感官评价,由此进行评分。
5分:感觉到污垢脱落很彻底
4分:感觉到污垢脱落
3分:不能说是否感觉到污垢脱落
2分:几乎感觉不到污垢脱落
1分:完全没有感觉到污垢脱落
合计10名小组成员的得分,根据以下的分类对清洗力的程度进行评价。将结果示于表1~4。
◎:45分以上
○:40分以上且小于45分
△:35分以上且小于40分
×:小于35分
<紧绷感评价>
对于所制备的皮肤清洗用喷雾剂,化妆品评价专门小组成员10名进行了紧绷感评价。具体而言,将各皮肤清洗用喷雾剂收纳于泵式喷雾容器(竹本容器株式会社制的“Z-155-C110(商品名)”,每1次按压的喷射量为0.15g)中,通过向脸直接喷雾1.5g而进行涂布。放置5秒左右,其后,以手不接触脸的方式用水冲洗。用毛巾按压脸并吸取水后,基于以下的指标对紧绷感进行感官评价,由此进行评分。紧绷感的程度越强,表示保湿越不足。
5分:完全感觉不到紧绷感
4分:几乎感觉不到紧绷感
3分:仅感觉到轻微的紧绷感
2分:感觉到紧绷感
1分:强烈感觉到紧绷感
合计10名小组成员的得分,根据以下的分类对紧绷感的程度进行评价。将结果示于表3~4。
◎:45分以上
○:40分以上且小于45分
△:35分以上且小于40分
×:小于35分
<培养表皮皮肤刺激试验(肌肤刺激性的in vitro评价)>
对于所制备的皮肤清洗用喷雾剂,如下所述地进行培养表皮皮肤刺激试验。
1.培养表皮模型LabCyte EPI-MODEL24的准备
加热试验培养基,向24孔试验板各添加0.5mL。将培养表皮模型LabCyte EPI-MODEL24(批号:LCE24-180226-A)转移到添加有试验培养基的24孔试验板。确认培养杯底面没有气泡后,放入CO2培养箱静置1小时以上直至暴露于受试物。
2.受试物的应用和清洗
使用表皮模型24个中的12个(其余持续进行预培养直至正式试验)。将24孔试验板从CO2培养箱中取出。加热试验培养基,向24孔试验板第3行各添加1.0mL。不使用泵式喷雾容器而向培养杯的培养表皮滴加受试物(各皮肤清洗用喷雾剂)25μL,遍及整体进行暴露。暴露后经过1分钟、5分钟、10分钟时吸引除去受试物,将杯内的培养表皮模型用磷酸盐缓冲液(PBS)清洗,转移到24孔试验板第3行。
3.MTT试验
MTT试验是如下方法:将摄入细胞内的MTT[3-(4,5-二甲基噻唑-2-基)-2,5-二苯基四唑溴化物]被位于细胞内的线粒体的脱氢酶还原而产生的甲臜色素通过有机溶剂提取,测定570nm的吸光度,由此测量活细胞率。
以最终浓度0.5mg/mL制备MTT培养基10mL。加热MTT培养基,向24孔试验板第4行各添加0.5mL。将培养表皮模型转移到24孔试验板第4行,放入CO2培养箱中,进行MTT反应3小时。MTT反应结束后,用镊子夹住培养皮肤并取出,移至1.5mL微型管。在微型管中加入异丙醇300μL而完全浸渍培养表皮模型。之后静置2小时,对微型管施加涡流,提取色素。将提取液(200mL)放入96孔板的各孔中。另外,作为空白(阴性对照),在A1中加入异丙醇200μL。用酶标仪测定570nm、650nm的吸光度。将570nm的吸光度减去650nm的吸光度而得到的值作为测定值,根据下述式计算受试物的活细胞率。
【数学式1】
基于以下的基准分类活细胞率,评价肌肤刺激性。将结果示于表3~4。
◎:90%以上
○:75%以上且小于90%
△:65%以上且小于75%
×:50%以上且小于65%
××:小于50%
如表1~4所示,以超过2重量%的浓度包含表面活性剂的皮肤清洗用喷雾剂(比较例13~16)确认到皮肤刺激性,以0.025~2重量%的浓度包含来源于天然的表面活性剂的皮肤清洗用喷雾剂(比较例1~10)没有确认到清洗力。与此相对,使单独不显示清洗力的两亲性酯(比较例11~12)与0.025~2重量%的来源于天然的表面活性剂同时含有的皮肤清洗用喷雾剂(实施例1~21),仅从喷雾式容器通过喷雾直接涂布于肌肤,从而完全不施加物理摩擦,仅利用液流的机械力就能得到优异的清洗力。即,示出了能够对肌肤进行柔和的清洗。而且,如实施例4~7、9、11、15、17~21所示,本发明的皮肤清洗用喷雾剂示出了能在抑制皮肤刺激性和因保湿不足所致的紧绷感的同时提高清洗力。即,示出了通过将利用喷雾而直接涂布于肌肤的皮肤清洗用喷雾剂的来源于天然的表面活性剂浓度设为0.025~2重量%,能够实现对肌肤在物理方面和化学方面都柔和的清洗。
【表1】
【表2】
【表3】
【表4】
表中,表示各成分的配合量的数值的单位为重量%。此外,括号内的数值表示成分换算量。
Claims (8)
1.一种皮肤清洗用喷雾剂,其含有(A)来源于天然的表面活性剂和(B)两亲性酯,
所述(A)的含量为0.025~2重量%,
所述皮肤清洗用喷雾剂收纳于喷雾式容器中。
2.根据权利要求1所述的皮肤清洗用喷雾剂,其中,所述喷雾式容器为泵式喷雾容器。
3.根据权利要求1所述的皮肤清洗用喷雾剂,其中,所述喷雾式容器为气溶胶式喷雾容器。
4.根据权利要求1~3中任一项所述的皮肤清洗用喷雾剂,其中,所述(A)成分选自由甘油磷脂、皂苷和脂肽组成的组。
5.根据权利要求4所述的皮肤清洗用喷雾剂,其中,所述甘油磷脂选自由卵磷脂、溶血卵磷脂和氢化卵磷脂组成的组。
6.根据权利要求4所述的皮肤清洗用喷雾剂,其中,所述脂肽选自由枯草菌脂肽及其盐组成的组。
7.根据权利要求1~6中任一项所述的皮肤清洗用喷雾剂,其中,所述(B)成分选自由二羧酸双(聚氧化烯烷基醚)酯、二羧酸二烷氧基烷基酯和聚甘油-10二十碳二酸酯/十四碳二酸酯组成的组。
8.根据权利要求7所述的皮肤清洗用喷雾剂,其中,所述二羧酸双(聚氧化烯烷基醚)酯为双-二乙氧基二甘醇环己烷1,4-二羧酸酯。
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CN113143797A (zh) * | 2021-04-20 | 2021-07-23 | 东晟源研究院(广州)有限公司 | 一种含改善雾化效果组合物的保湿化妆水及其制备方法 |
CN113712827A (zh) * | 2021-08-20 | 2021-11-30 | 华熙生物科技股份有限公司 | 含硅酸盐和枯草菌脂肽钠的喷雾乳液产品及其制备方法 |
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