JP2020536903A5 - - Google Patents

Info

Publication number

JP2020536903A5

JP2020536903A5 JP2020520290A JP2020520290A JP2020536903A5 JP 2020536903 A5 JP2020536903 A5 JP 2020536903A5 JP 2020520290 A JP2020520290 A JP 2020520290A JP 2020520290 A JP2020520290 A JP 2020520290A JP 2020536903 A5 JP2020536903 A5 JP 2020536903A5

Authority

JP

Japan

Prior art keywords

formulation

prostate cancer

castration

pharmaceutical composition

prednisone

Prior art date

2018-02-08

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
• Discuss

• 238000000034 method Methods 0.000 claims description 74
• 238000009472 formulation Methods 0.000 claims description 58
• 239000000203 mixture Substances 0.000 claims description 58
• QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 claims description 50
• 206010060862 Prostate cancer Diseases 0.000 claims description 45
• 208000000236 Prostatic Neoplasms Diseases 0.000 claims description 45
• 230000001394 metastastic effect Effects 0.000 claims description 45
• 206010061289 metastatic neoplasm Diseases 0.000 claims description 45
• XOFYZVNMUHMLCC-ZPOLXVRWSA-N prednisone Chemical compound O=C1C=C[C@]2(C)[C@H]3C(=O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 XOFYZVNMUHMLCC-ZPOLXVRWSA-N 0.000 claims description 36
• 229960004618 prednisone Drugs 0.000 claims description 36
• 239000003098 androgen Substances 0.000 claims description 25
• 238000002560 therapeutic procedure Methods 0.000 claims description 18
• 230000004083 survival effect Effects 0.000 claims description 15
• 238000002648 combination therapy Methods 0.000 claims description 14
• 241000282412 Homo Species 0.000 claims description 8
• 238000010317 ablation therapy Methods 0.000 claims description 8
• 229940079593 drug Drugs 0.000 claims description 8
• 239000003814 drug Substances 0.000 claims description 8
• 230000005713 exacerbation Effects 0.000 claims description 7
• 210000000988 bone and bone Anatomy 0.000 claims description 3
• 108010069236 Goserelin Proteins 0.000 claims description 2
• 108010000817 Leuprolide Proteins 0.000 claims description 2
• 238000002679 ablation Methods 0.000 claims description 2
• 239000003795 chemical substances by application Substances 0.000 claims description 2
• 229960003690 goserelin acetate Drugs 0.000 claims description 2
• 229960003911 histrelin acetate Drugs 0.000 claims description 2
• BKEMVGVBBDMHKL-VYFXDUNUSA-N histrelin acetate Chemical compound CC(O)=O.CC(O)=O.CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H]1NC(=O)CC1)CC(N=C1)=CN1CC1=CC=CC=C1 BKEMVGVBBDMHKL-VYFXDUNUSA-N 0.000 claims description 2
• 229940088597 hormone Drugs 0.000 claims description 2
• 239000005556 hormone Substances 0.000 claims description 2
• GFIJNRVAKGFPGQ-LIJARHBVSA-N leuprolide Chemical compound CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H]1NC(=O)CC1)CC1=CC=C(O)C=C1 GFIJNRVAKGFPGQ-LIJARHBVSA-N 0.000 claims description 2
• 229960004338 leuprorelin Drugs 0.000 claims description 2
• BLCLNMBMMGCOAS-UHFFFAOYSA-N n-[1-[[1-[[1-[[1-[[1-[[1-[[1-[2-[(carbamoylamino)carbamoyl]pyrrolidin-1-yl]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-[(2-methylpropan-2-yl)oxy]-1-oxopropan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amin Chemical compound C1CCC(C(=O)NNC(N)=O)N1C(=O)C(CCCN=C(N)N)NC(=O)C(CC(C)C)NC(=O)C(COC(C)(C)C)NC(=O)C(NC(=O)C(CO)NC(=O)C(CC=1C2=CC=CC=C2NC=1)NC(=O)C(CC=1NC=NC=1)NC(=O)C1NC(=O)CC1)CC1=CC=C(O)C=C1 BLCLNMBMMGCOAS-UHFFFAOYSA-N 0.000 claims description 2
• 238000011474 orchiectomy Methods 0.000 claims description 2
• 239000008194 pharmaceutical composition Substances 0.000 claims 32
• 229960004103 abiraterone acetate Drugs 0.000 claims 2
• UVIQSJCZCSLXRZ-UBUQANBQSA-N abiraterone acetate Chemical compound C([C@@H]1[C@]2(C)CC[C@@H]3[C@@]4(C)CC[C@@H](CC4=CC[C@H]31)OC(=O)C)C=C2C1=CC=CN=C1 UVIQSJCZCSLXRZ-UBUQANBQSA-N 0.000 claims 2
• 239000013583 drug formulation Substances 0.000 claims 1
• 238000004519 manufacturing process Methods 0.000 claims 1
• 206010028980 Neoplasm Diseases 0.000 description 2
• 201000011510 cancer Diseases 0.000 description 2
• 238000012986 modification Methods 0.000 description 2
• 230000004048 modification Effects 0.000 description 2
• 210000002307 prostate Anatomy 0.000 description 2