BR112020007090A2 - métodos de tratamento de câncer de próstata mediante a administração de acetato de abiraterona mais prednisona com terapia de supressão androgênica - Google Patents
métodos de tratamento de câncer de próstata mediante a administração de acetato de abiraterona mais prednisona com terapia de supressão androgênica Download PDFInfo
- Publication number
- BR112020007090A2 BR112020007090A2 BR112020007090-4A BR112020007090A BR112020007090A2 BR 112020007090 A2 BR112020007090 A2 BR 112020007090A2 BR 112020007090 A BR112020007090 A BR 112020007090A BR 112020007090 A2 BR112020007090 A2 BR 112020007090A2
- Authority
- BR
- Brazil
- Prior art keywords
- pharmaceutical product
- patients
- prednisone
- zytiga
- abiraterone acetate
- Prior art date
Links
- 229960004618 prednisone Drugs 0.000 title claims abstract description 124
- XOFYZVNMUHMLCC-ZPOLXVRWSA-N prednisone Chemical compound O=C1C=C[C@]2(C)[C@H]3C(=O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 XOFYZVNMUHMLCC-ZPOLXVRWSA-N 0.000 title claims abstract description 116
- 229960004103 abiraterone acetate Drugs 0.000 title claims abstract description 105
- UVIQSJCZCSLXRZ-UBUQANBQSA-N abiraterone acetate Chemical compound C([C@@H]1[C@]2(C)CC[C@@H]3[C@@]4(C)CC[C@@H](CC4=CC[C@H]31)OC(=O)C)C=C2C1=CC=CN=C1 UVIQSJCZCSLXRZ-UBUQANBQSA-N 0.000 title claims abstract description 104
- 238000000034 method Methods 0.000 title claims abstract description 55
- 238000009167 androgen deprivation therapy Methods 0.000 title claims abstract description 48
- 206010060862 Prostate cancer Diseases 0.000 title abstract description 41
- 208000000236 Prostatic Neoplasms Diseases 0.000 title abstract description 41
- 238000011282 treatment Methods 0.000 claims description 125
- 230000004083 survival effect Effects 0.000 claims description 70
- 239000000825 pharmaceutical preparation Substances 0.000 claims description 60
- 229940127557 pharmaceutical product Drugs 0.000 claims description 60
- 239000003814 drug Substances 0.000 claims description 59
- 229940079593 drug Drugs 0.000 claims description 50
- 208000010658 metastatic prostate carcinoma Diseases 0.000 claims description 45
- 238000002560 therapeutic procedure Methods 0.000 claims description 24
- 208000002193 Pain Diseases 0.000 claims description 23
- 238000011474 orchiectomy Methods 0.000 claims description 14
- 230000003054 hormonal effect Effects 0.000 claims description 12
- 238000002648 combination therapy Methods 0.000 claims description 11
- 108010069236 Goserelin Proteins 0.000 claims description 4
- 108010000817 Leuprolide Proteins 0.000 claims description 4
- 238000002679 ablation Methods 0.000 claims description 4
- 230000001548 androgenic effect Effects 0.000 claims description 4
- 229960003911 histrelin acetate Drugs 0.000 claims description 4
- BKEMVGVBBDMHKL-VYFXDUNUSA-N histrelin acetate Chemical compound CC(O)=O.CC(O)=O.CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H]1NC(=O)CC1)CC(N=C1)=CN1CC1=CC=CC=C1 BKEMVGVBBDMHKL-VYFXDUNUSA-N 0.000 claims description 4
- GFIJNRVAKGFPGQ-LIJARHBVSA-N leuprolide Chemical compound CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H]1NC(=O)CC1)CC1=CC=C(O)C=C1 GFIJNRVAKGFPGQ-LIJARHBVSA-N 0.000 claims description 4
- 229960004338 leuprorelin Drugs 0.000 claims description 4
- 230000001629 suppression Effects 0.000 claims description 4
- 239000003795 chemical substances by application Substances 0.000 claims description 3
- 229960004824 triptorelin Drugs 0.000 claims description 3
- VXKHXGOKWPXYNA-PGBVPBMZSA-N triptorelin Chemical compound C([C@@H](C(=O)N[C@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1[C@@H](CCC1)C(=O)NCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H]1NC(=O)CC1)C1=CC=C(O)C=C1 VXKHXGOKWPXYNA-PGBVPBMZSA-N 0.000 claims description 3
- 229960003690 goserelin acetate Drugs 0.000 claims description 2
- 208000037819 metastatic cancer Diseases 0.000 claims description 2
- 208000011575 metastatic malignant neoplasm Diseases 0.000 claims description 2
- BLCLNMBMMGCOAS-UHFFFAOYSA-N n-[1-[[1-[[1-[[1-[[1-[[1-[[1-[2-[(carbamoylamino)carbamoyl]pyrrolidin-1-yl]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-[(2-methylpropan-2-yl)oxy]-1-oxopropan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amin Chemical compound C1CCC(C(=O)NNC(N)=O)N1C(=O)C(CCCN=C(N)N)NC(=O)C(CC(C)C)NC(=O)C(COC(C)(C)C)NC(=O)C(NC(=O)C(CO)NC(=O)C(CC=1C2=CC=CC=C2NC=1)NC(=O)C(CC=1NC=NC=1)NC(=O)C1NC(=O)CC1)CC1=CC=C(O)C=C1 BLCLNMBMMGCOAS-UHFFFAOYSA-N 0.000 claims description 2
- GZOSMCIZMLWJML-VJLLXTKPSA-N abiraterone Chemical compound C([C@H]1[C@H]2[C@@H]([C@]3(CC[C@H](O)CC3=CC2)C)CC[C@@]11C)C=C1C1=CC=CN=C1 GZOSMCIZMLWJML-VJLLXTKPSA-N 0.000 description 261
- 229940051084 zytiga Drugs 0.000 description 216
- 239000000902 placebo Substances 0.000 description 88
- 229940068196 placebo Drugs 0.000 description 62
- 229960000853 abiraterone Drugs 0.000 description 54
- 231100000517 death Toxicity 0.000 description 43
- 230000034994 death Effects 0.000 description 43
- 239000003826 tablet Substances 0.000 description 42
- 238000004458 analytical method Methods 0.000 description 39
- 206010061289 metastatic neoplasm Diseases 0.000 description 37
- 230000001394 metastastic effect Effects 0.000 description 34
- 230000000694 effects Effects 0.000 description 31
- 206010019663 Hepatic failure Diseases 0.000 description 28
- 231100000835 liver failure Toxicity 0.000 description 28
- 208000007903 liver failure Diseases 0.000 description 28
- 208000019025 Hypokalemia Diseases 0.000 description 25
- 206010067484 Adverse reaction Diseases 0.000 description 23
- 206010020772 Hypertension Diseases 0.000 description 23
- 230000002411 adverse Effects 0.000 description 22
- 230000006838 adverse reaction Effects 0.000 description 22
- 206010028980 Neoplasm Diseases 0.000 description 19
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 19
- BPYKTIZUTYGOLE-IFADSCNNSA-N Bilirubin Chemical compound N1C(=O)C(C)=C(C=C)\C1=C\C1=C(C)C(CCC(O)=O)=C(CC2=C(C(C)=C(\C=C/3C(=C(C=C)C(=O)N\3)C)N2)CCC(O)=O)N1 BPYKTIZUTYGOLE-IFADSCNNSA-N 0.000 description 18
- 241000700159 Rattus Species 0.000 description 18
- 108010072866 Prostate-Specific Antigen Proteins 0.000 description 17
- 102100038358 Prostate-specific antigen Human genes 0.000 description 17
- 231100000304 hepatotoxicity Toxicity 0.000 description 17
- 206010019851 Hepatotoxicity Diseases 0.000 description 16
- MUMGGOZAMZWBJJ-DYKIIFRCSA-N Testostosterone Chemical compound O=C1CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 MUMGGOZAMZWBJJ-DYKIIFRCSA-N 0.000 description 16
- 230000007686 hepatotoxicity Effects 0.000 description 16
- 201000010099 disease Diseases 0.000 description 15
- 239000007941 film coated tablet Substances 0.000 description 15
- 206010013710 Drug interaction Diseases 0.000 description 14
- 230000003908 liver function Effects 0.000 description 14
- 235000012054 meals Nutrition 0.000 description 14
- 239000000556 agonist Substances 0.000 description 13
- 239000000758 substrate Substances 0.000 description 13
- 208000000130 Cytochrome P-450 CYP3A Inducers Diseases 0.000 description 12
- 206010016807 Fluid retention Diseases 0.000 description 12
- 101000904173 Homo sapiens Progonadoliberin-1 Proteins 0.000 description 12
- 102100024028 Progonadoliberin-1 Human genes 0.000 description 12
- 101000996723 Sus scrofa Gonadotropin-releasing hormone receptor Proteins 0.000 description 12
- 208000017515 adrenocortical insufficiency Diseases 0.000 description 12
- 239000003098 androgen Substances 0.000 description 12
- 238000011393 cytotoxic chemotherapy Methods 0.000 description 12
- XLXSAKCOAKORKW-UHFFFAOYSA-N gonadorelin Chemical compound C1CCC(C(=O)NCC(N)=O)N1C(=O)C(CCCN=C(N)N)NC(=O)C(CC(C)C)NC(=O)CNC(=O)C(NC(=O)C(CO)NC(=O)C(CC=1C2=CC=CC=C2NC=1)NC(=O)C(CC=1NC=NC=1)NC(=O)C1NC(=O)CC1)CC1=CC=C(O)C=C1 XLXSAKCOAKORKW-UHFFFAOYSA-N 0.000 description 12
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 12
- 230000004044 response Effects 0.000 description 12
- 206010019280 Heart failures Diseases 0.000 description 11
- 108010015330 Steroid 17-alpha-Hydroxylase Proteins 0.000 description 11
- 230000005856 abnormality Effects 0.000 description 11
- 230000008901 benefit Effects 0.000 description 11
- 230000009885 systemic effect Effects 0.000 description 11
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 10
- 108010001237 Cytochrome P-450 CYP2D6 Proteins 0.000 description 10
- 102100021704 Cytochrome P450 2D6 Human genes 0.000 description 10
- ZDZOTLJHXYCWBA-VCVYQWHSSA-N N-debenzoyl-N-(tert-butoxycarbonyl)-10-deacetyltaxol Chemical compound O([C@H]1[C@H]2[C@@](C([C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)C=4C=CC=CC=4)C[C@]1(O)C3(C)C)=O)(C)[C@@H](O)C[C@H]1OC[C@]12OC(=O)C)C(=O)C1=CC=CC=C1 ZDZOTLJHXYCWBA-VCVYQWHSSA-N 0.000 description 10
- 201000011510 cancer Diseases 0.000 description 10
- 229960003668 docetaxel Drugs 0.000 description 10
- 208000015181 infectious disease Diseases 0.000 description 10
- 230000003902 lesion Effects 0.000 description 10
- 230000003389 potentiating effect Effects 0.000 description 10
- 230000009467 reduction Effects 0.000 description 10
- 230000002829 reductive effect Effects 0.000 description 10
- 210000002966 serum Anatomy 0.000 description 10
- 206010030113 Oedema Diseases 0.000 description 9
- 238000008050 Total Bilirubin Reagent Methods 0.000 description 9
- 238000002512 chemotherapy Methods 0.000 description 9
- 230000001850 reproductive effect Effects 0.000 description 9
- 208000024891 symptom Diseases 0.000 description 9
- 108010081668 Cytochrome P-450 CYP3A Proteins 0.000 description 8
- 241001465754 Metazoa Species 0.000 description 8
- 101000857870 Squalus acanthias Gonadoliberin Proteins 0.000 description 8
- 102100021719 Steroid 17-alpha-hydroxylase/17,20 lyase Human genes 0.000 description 8
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 8
- 238000007469 bone scintigraphy Methods 0.000 description 8
- 235000013305 food Nutrition 0.000 description 8
- 238000000338 in vitro Methods 0.000 description 8
- 230000004048 modification Effects 0.000 description 8
- 238000012986 modification Methods 0.000 description 8
- 210000000056 organ Anatomy 0.000 description 8
- HYAFETHFCAUJAY-UHFFFAOYSA-N pioglitazone Chemical compound N1=CC(CC)=CC=C1CCOC(C=C1)=CC=C1CC1C(=O)NC(=O)S1 HYAFETHFCAUJAY-UHFFFAOYSA-N 0.000 description 8
- 230000035935 pregnancy Effects 0.000 description 8
- 239000000047 product Substances 0.000 description 8
- 238000012360 testing method Methods 0.000 description 8
- 229960003604 testosterone Drugs 0.000 description 8
- 206010061818 Disease progression Diseases 0.000 description 7
- 230000002280 anti-androgenic effect Effects 0.000 description 7
- 239000000051 antiandrogen Substances 0.000 description 7
- 230000015572 biosynthetic process Effects 0.000 description 7
- 238000006243 chemical reaction Methods 0.000 description 7
- 238000002591 computed tomography Methods 0.000 description 7
- 230000007423 decrease Effects 0.000 description 7
- 230000005750 disease progression Effects 0.000 description 7
- 239000003112 inhibitor Substances 0.000 description 7
- WSVLPVUVIUVCRA-KPKNDVKVSA-N Alpha-lactose monohydrate Chemical compound O.O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O WSVLPVUVIUVCRA-KPKNDVKVSA-N 0.000 description 6
- 206010011224 Cough Diseases 0.000 description 6
- 229920002785 Croscarmellose sodium Polymers 0.000 description 6
- 108010000561 Cytochrome P-450 CYP2C8 Proteins 0.000 description 6
- 102100029359 Cytochrome P450 2C8 Human genes 0.000 description 6
- 102100039205 Cytochrome P450 3A4 Human genes 0.000 description 6
- 102000004190 Enzymes Human genes 0.000 description 6
- 108090000790 Enzymes Proteins 0.000 description 6
- 206010027476 Metastases Diseases 0.000 description 6
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 6
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 6
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 6
- 229940075614 colloidal silicon dioxide Drugs 0.000 description 6
- 229960001681 croscarmellose sodium Drugs 0.000 description 6
- 235000010947 crosslinked sodium carboxy methyl cellulose Nutrition 0.000 description 6
- 230000035558 fertility Effects 0.000 description 6
- 230000006872 improvement Effects 0.000 description 6
- 229960001021 lactose monohydrate Drugs 0.000 description 6
- 210000004185 liver Anatomy 0.000 description 6
- 235000019359 magnesium stearate Nutrition 0.000 description 6
- 229940057948 magnesium stearate Drugs 0.000 description 6
- 210000002307 prostate Anatomy 0.000 description 6
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 6
- 210000002784 stomach Anatomy 0.000 description 6
- 230000009278 visceral effect Effects 0.000 description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 6
- 208000006820 Arthralgia Diseases 0.000 description 5
- 241000282693 Cercopithecidae Species 0.000 description 5
- 206010012735 Diarrhoea Diseases 0.000 description 5
- 206010019233 Headaches Diseases 0.000 description 5
- 241000282412 Homo Species 0.000 description 5
- MKXZASYAUGDDCJ-SZMVWBNQSA-N LSM-2525 Chemical compound C1CCC[C@H]2[C@@]3([H])N(C)CC[C@]21C1=CC(OC)=CC=C1C3 MKXZASYAUGDDCJ-SZMVWBNQSA-N 0.000 description 5
- 206010028813 Nausea Diseases 0.000 description 5
- 230000001919 adrenal effect Effects 0.000 description 5
- 238000013475 authorization Methods 0.000 description 5
- 230000002146 bilateral effect Effects 0.000 description 5
- 210000004369 blood Anatomy 0.000 description 5
- 239000008280 blood Substances 0.000 description 5
- 238000009534 blood test Methods 0.000 description 5
- 230000006378 damage Effects 0.000 description 5
- 230000003247 decreasing effect Effects 0.000 description 5
- 238000009826 distribution Methods 0.000 description 5
- 238000011156 evaluation Methods 0.000 description 5
- 231100000869 headache Toxicity 0.000 description 5
- 239000004615 ingredient Substances 0.000 description 5
- 230000005764 inhibitory process Effects 0.000 description 5
- 238000002595 magnetic resonance imaging Methods 0.000 description 5
- 230000010534 mechanism of action Effects 0.000 description 5
- 239000002395 mineralocorticoid Substances 0.000 description 5
- 239000000203 mixture Substances 0.000 description 5
- 230000008693 nausea Effects 0.000 description 5
- 229940037129 plain mineralocorticoids for systemic use Drugs 0.000 description 5
- 238000001356 surgical procedure Methods 0.000 description 5
- 230000001988 toxicity Effects 0.000 description 5
- 231100000419 toxicity Toxicity 0.000 description 5
- 231100000027 toxicology Toxicity 0.000 description 5
- 206010061728 Bone lesion Diseases 0.000 description 4
- UQSXHKLRYXJYBZ-UHFFFAOYSA-N Iron oxide Chemical compound [Fe]=O UQSXHKLRYXJYBZ-UHFFFAOYSA-N 0.000 description 4
- 206010025327 Lymphopenia Diseases 0.000 description 4
- 206010027457 Metastases to liver Diseases 0.000 description 4
- 229920000168 Microcrystalline cellulose Polymers 0.000 description 4
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 description 4
- 206010030124 Oedema peripheral Diseases 0.000 description 4
- 208000001647 Renal Insufficiency Diseases 0.000 description 4
- 102000001854 Steroid 17-alpha-Hydroxylase Human genes 0.000 description 4
- 206010047700 Vomiting Diseases 0.000 description 4
- 239000004480 active ingredient Substances 0.000 description 4
- 239000008186 active pharmaceutical agent Substances 0.000 description 4
- 208000007502 anemia Diseases 0.000 description 4
- 206010003119 arrhythmia Diseases 0.000 description 4
- 230000006793 arrhythmia Effects 0.000 description 4
- 210000000988 bone and bone Anatomy 0.000 description 4
- 210000004027 cell Anatomy 0.000 description 4
- 238000011260 co-administration Methods 0.000 description 4
- 229960001985 dextromethorphan Drugs 0.000 description 4
- 208000035475 disorder Diseases 0.000 description 4
- 206010016256 fatigue Diseases 0.000 description 4
- 201000001421 hyperglycemia Diseases 0.000 description 4
- 230000000977 initiatory effect Effects 0.000 description 4
- 230000003993 interaction Effects 0.000 description 4
- JEIPFZHSYJVQDO-UHFFFAOYSA-N iron(III) oxide Inorganic materials O=[Fe]O[Fe]=O JEIPFZHSYJVQDO-UHFFFAOYSA-N 0.000 description 4
- 201000006370 kidney failure Diseases 0.000 description 4
- 238000002372 labelling Methods 0.000 description 4
- 238000007449 liver function test Methods 0.000 description 4
- 238000001325 log-rank test Methods 0.000 description 4
- 231100001023 lymphopenia Toxicity 0.000 description 4
- 238000004519 manufacturing process Methods 0.000 description 4
- 229940016286 microcrystalline cellulose Drugs 0.000 description 4
- 235000019813 microcrystalline cellulose Nutrition 0.000 description 4
- 239000008108 microcrystalline cellulose Substances 0.000 description 4
- 230000000144 pharmacologic effect Effects 0.000 description 4
- 229960005095 pioglitazone Drugs 0.000 description 4
- 229920001223 polyethylene glycol Polymers 0.000 description 4
- 229920002451 polyvinyl alcohol Polymers 0.000 description 4
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 4
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 4
- 208000024896 potassium deficiency disease Diseases 0.000 description 4
- 229940069328 povidone Drugs 0.000 description 4
- 210000002345 respiratory system Anatomy 0.000 description 4
- 238000011268 retreatment Methods 0.000 description 4
- 238000003860 storage Methods 0.000 description 4
- 239000000454 talc Substances 0.000 description 4
- 229910052623 talc Inorganic materials 0.000 description 4
- ZFXYFBGIUFBOJW-UHFFFAOYSA-N theophylline Chemical compound O=C1N(C)C(=O)N(C)C2=C1NC=N2 ZFXYFBGIUFBOJW-UHFFFAOYSA-N 0.000 description 4
- 239000004408 titanium dioxide Substances 0.000 description 4
- 231100000402 unacceptable toxicity Toxicity 0.000 description 4
- 230000008673 vomiting Effects 0.000 description 4
- XMAYWYJOQHXEEK-OZXSUGGESA-N (2R,4S)-ketoconazole Chemical compound C1CN(C(=O)C)CCN1C(C=C1)=CC=C1OC[C@@H]1O[C@@](CN2C=NC=C2)(C=2C(=CC(Cl)=CC=2)Cl)OC1 XMAYWYJOQHXEEK-OZXSUGGESA-N 0.000 description 3
- 102100033350 ATP-dependent translocase ABCB1 Human genes 0.000 description 3
- 102100036475 Alanine aminotransferase 1 Human genes 0.000 description 3
- 108010082126 Alanine transaminase Proteins 0.000 description 3
- 108010003415 Aspartate Aminotransferases Proteins 0.000 description 3
- 102000004625 Aspartate Aminotransferases Human genes 0.000 description 3
- 108700012941 GNRH1 Proteins 0.000 description 3
- 239000000579 Gonadotropin-Releasing Hormone Substances 0.000 description 3
- 208000029027 Musculoskeletal and connective tissue disease Diseases 0.000 description 3
- 208000032327 Respiratory, thoracic and mediastinal disease Diseases 0.000 description 3
- 206010041549 Spinal cord compression Diseases 0.000 description 3
- 108010050144 Triptorelin Pamoate Proteins 0.000 description 3
- 230000002159 abnormal effect Effects 0.000 description 3
- 210000004100 adrenal gland Anatomy 0.000 description 3
- 102000001307 androgen receptors Human genes 0.000 description 3
- 108010080146 androgen receptors Proteins 0.000 description 3
- 229940030486 androgens Drugs 0.000 description 3
- 238000003556 assay Methods 0.000 description 3
- 230000036772 blood pressure Effects 0.000 description 3
- 231100000504 carcinogenesis Toxicity 0.000 description 3
- 208000020832 chronic kidney disease Diseases 0.000 description 3
- 238000012790 confirmation Methods 0.000 description 3
- 239000003433 contraceptive agent Substances 0.000 description 3
- 238000003745 diagnosis Methods 0.000 description 3
- 239000002552 dosage form Substances 0.000 description 3
- 201000000523 end stage renal failure Diseases 0.000 description 3
- 230000001605 fetal effect Effects 0.000 description 3
- 210000003754 fetus Anatomy 0.000 description 3
- 208000019622 heart disease Diseases 0.000 description 3
- 229920001903 high density polyethylene Polymers 0.000 description 3
- 239000004700 high-density polyethylene Substances 0.000 description 3
- 208000006575 hypertriglyceridemia Diseases 0.000 description 3
- 238000002513 implantation Methods 0.000 description 3
- 238000001727 in vivo Methods 0.000 description 3
- 229960004125 ketoconazole Drugs 0.000 description 3
- 238000012544 monitoring process Methods 0.000 description 3
- 231100000350 mutagenesis Toxicity 0.000 description 3
- 238000002703 mutagenesis Methods 0.000 description 3
- 208000010125 myocardial infarction Diseases 0.000 description 3
- 239000002547 new drug Substances 0.000 description 3
- 229940127240 opiate Drugs 0.000 description 3
- 239000006186 oral dosage form Substances 0.000 description 3
- 230000001817 pituitary effect Effects 0.000 description 3
- 238000010837 poor prognosis Methods 0.000 description 3
- 230000005855 radiation Effects 0.000 description 3
- 238000001959 radiotherapy Methods 0.000 description 3
- 210000004994 reproductive system Anatomy 0.000 description 3
- 238000012552 review Methods 0.000 description 3
- JQXXHWHPUNPDRT-WLSIYKJHSA-N rifampicin Chemical compound O([C@](C1=O)(C)O/C=C/[C@@H]([C@H]([C@@H](OC(C)=O)[C@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@@H](C)\C=C\C=C(C)/C(=O)NC=2C(O)=C3C([O-])=C4C)C)OC)C4=C1C3=C(O)C=2\C=N\N1CC[NH+](C)CC1 JQXXHWHPUNPDRT-WLSIYKJHSA-N 0.000 description 3
- 229960001225 rifampicin Drugs 0.000 description 3
- 231100000279 safety data Toxicity 0.000 description 3
- 210000001550 testis Anatomy 0.000 description 3
- 231100001274 therapeutic index Toxicity 0.000 description 3
- 208000019553 vascular disease Diseases 0.000 description 3
- GUBGYTABKSRVRQ-UHFFFAOYSA-N 2-(hydroxymethyl)-6-[4,5,6-trihydroxy-2-(hydroxymethyl)oxan-3-yl]oxyoxane-3,4,5-triol Chemical compound OCC1OC(OC2C(O)C(O)C(O)OC2CO)C(O)C(O)C1O GUBGYTABKSRVRQ-UHFFFAOYSA-N 0.000 description 2
- 208000007788 Acute Liver Failure Diseases 0.000 description 2
- 206010000804 Acute hepatic failure Diseases 0.000 description 2
- 206010001367 Adrenal insufficiency Diseases 0.000 description 2
- 108020004774 Alkaline Phosphatase Proteins 0.000 description 2
- 102000002260 Alkaline Phosphatase Human genes 0.000 description 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- 206010003658 Atrial Fibrillation Diseases 0.000 description 2
- 206010006002 Bone pain Diseases 0.000 description 2
- 208000005623 Carcinogenesis Diseases 0.000 description 2
- 208000020446 Cardiac disease Diseases 0.000 description 2
- 206010007559 Cardiac failure congestive Diseases 0.000 description 2
- 208000024172 Cardiovascular disease Diseases 0.000 description 2
- 208000002177 Cataract Diseases 0.000 description 2
- 206010008479 Chest Pain Diseases 0.000 description 2
- 108010074922 Cytochrome P-450 CYP1A2 Proteins 0.000 description 2
- 102100026533 Cytochrome P450 1A2 Human genes 0.000 description 2
- 108090000371 Esterases Proteins 0.000 description 2
- 208000018522 Gastrointestinal disease Diseases 0.000 description 2
- 206010018092 Generalised oedema Diseases 0.000 description 2
- BLCLNMBMMGCOAS-URPVMXJPSA-N Goserelin Chemical compound C([C@@H](C(=O)N[C@H](COC(C)(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1[C@@H](CCC1)C(=O)NNC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H]1NC(=O)CC1)C1=CC=C(O)C=C1 BLCLNMBMMGCOAS-URPVMXJPSA-N 0.000 description 2
- 208000010496 Heart Arrest Diseases 0.000 description 2
- 101001017818 Homo sapiens ATP-dependent translocase ABCB1 Proteins 0.000 description 2
- 101000585365 Homo sapiens Sulfotransferase 2A1 Proteins 0.000 description 2
- 208000033830 Hot Flashes Diseases 0.000 description 2
- 206010060800 Hot flush Diseases 0.000 description 2
- 208000035150 Hypercholesterolemia Diseases 0.000 description 2
- 208000032911 Injury, poisoning and procedural complications Diseases 0.000 description 2
- 206010023230 Joint stiffness Diseases 0.000 description 2
- 206010023232 Joint swelling Diseases 0.000 description 2
- 208000001940 Massive Hepatic Necrosis Diseases 0.000 description 2
- 206010053156 Musculoskeletal discomfort Diseases 0.000 description 2
- AEEMBGRHVQPUBV-VJLLXTKPSA-N N-Oxide abiraterone sulfate Chemical compound C[C@]12CC[C@H]3[C@@H](CC=C4C[C@H](CC[C@]34C)OS(O)(=O)=O)[C@@H]1CC=C2c1ccc[n+]([O-])c1 AEEMBGRHVQPUBV-VJLLXTKPSA-N 0.000 description 2
- 206010034156 Pathological fracture Diseases 0.000 description 2
- 206010035664 Pneumonia Diseases 0.000 description 2
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 2
- RJKFOVLPORLFTN-LEKSSAKUSA-N Progesterone Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](C(=O)C)[C@@]1(C)CC2 RJKFOVLPORLFTN-LEKSSAKUSA-N 0.000 description 2
- 208000032023 Signs and Symptoms Diseases 0.000 description 2
- 208000005250 Spontaneous Fractures Diseases 0.000 description 2
- 102100029867 Sulfotransferase 2A1 Human genes 0.000 description 2
- 108090000340 Transaminases Proteins 0.000 description 2
- 102000003929 Transaminases Human genes 0.000 description 2
- LUQSJWRTYLGZJB-VJLLXTKPSA-N [(3S,8R,9S,10R,13S,14S)-10,13-dimethyl-17-pyridin-3-yl-2,3,4,7,8,9,11,12,14,15-decahydro-1H-cyclopenta[a]phenanthren-3-yl] hydrogen sulfate Chemical compound C[C@]12CC[C@H]3[C@@H](CC=C4C[C@H](CC[C@]34C)OS(O)(=O)=O)[C@@H]1CC=C2c1cccnc1 LUQSJWRTYLGZJB-VJLLXTKPSA-N 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 2
- 231100000836 acute liver failure Toxicity 0.000 description 2
- AEMFNILZOJDQLW-QAGGRKNESA-N androst-4-ene-3,17-dione Chemical compound O=C1CC[C@]2(C)[C@H]3CC[C@](C)(C(CC4)=O)[C@@H]4[C@@H]3CCC2=C1 AEMFNILZOJDQLW-QAGGRKNESA-N 0.000 description 2
- 229960005471 androstenedione Drugs 0.000 description 2
- AEMFNILZOJDQLW-UHFFFAOYSA-N androstenedione Natural products O=C1CCC2(C)C3CCC(C)(C(CC4)=O)C4C3CCC2=C1 AEMFNILZOJDQLW-UHFFFAOYSA-N 0.000 description 2
- HJBWBFZLDZWPHF-UHFFFAOYSA-N apalutamide Chemical compound C1=C(F)C(C(=O)NC)=CC=C1N1C2(CCC2)C(=O)N(C=2C=C(C(C#N)=NC=2)C(F)(F)F)C1=S HJBWBFZLDZWPHF-UHFFFAOYSA-N 0.000 description 2
- 229950007511 apalutamide Drugs 0.000 description 2
- 206010003246 arthritis Diseases 0.000 description 2
- 230000000903 blocking effect Effects 0.000 description 2
- 208000006218 bradycardia Diseases 0.000 description 2
- 230000036952 cancer formation Effects 0.000 description 2
- 230000000711 cancerogenic effect Effects 0.000 description 2
- 231100000315 carcinogenic Toxicity 0.000 description 2
- 230000000747 cardiac effect Effects 0.000 description 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 2
- 230000001684 chronic effect Effects 0.000 description 2
- 239000011248 coating agent Substances 0.000 description 2
- 238000000576 coating method Methods 0.000 description 2
- 230000002254 contraceptive effect Effects 0.000 description 2
- 239000003246 corticosteroid Substances 0.000 description 2
- 229960001334 corticosteroids Drugs 0.000 description 2
- FMGSKLZLMKYGDP-USOAJAOKSA-N dehydroepiandrosterone Chemical compound C1[C@@H](O)CC[C@]2(C)[C@H]3CC[C@](C)(C(CC4)=O)[C@@H]4[C@@H]3CC=C21 FMGSKLZLMKYGDP-USOAJAOKSA-N 0.000 description 2
- 238000000502 dialysis Methods 0.000 description 2
- 201000006549 dyspepsia Diseases 0.000 description 2
- 208000028208 end stage renal disease Diseases 0.000 description 2
- 229960004671 enzalutamide Drugs 0.000 description 2
- WXCXUHSOUPDCQV-UHFFFAOYSA-N enzalutamide Chemical compound C1=C(F)C(C(=O)NC)=CC=C1N1C(C)(C)C(=O)N(C=2C=C(C(C#N)=CC=2)C(F)(F)F)C1=S WXCXUHSOUPDCQV-UHFFFAOYSA-N 0.000 description 2
- 230000007717 exclusion Effects 0.000 description 2
- 235000020937 fasting conditions Nutrition 0.000 description 2
- 210000003608 fece Anatomy 0.000 description 2
- SZVJSHCCFOBDDC-UHFFFAOYSA-N ferrosoferric oxide Chemical compound O=[Fe]O[Fe]O[Fe]=O SZVJSHCCFOBDDC-UHFFFAOYSA-N 0.000 description 2
- 231100000502 fertility decrease Toxicity 0.000 description 2
- 239000007888 film coating Substances 0.000 description 2
- 238000009501 film coating Methods 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- -1 fulminant hepatitis Chemical compound 0.000 description 2
- 239000003168 generic drug Substances 0.000 description 2
- XLXSAKCOAKORKW-AQJXLSMYSA-N gonadorelin Chemical class C([C@@H](C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1[C@@H](CCC1)C(=O)NCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H]1NC(=O)CC1)C1=CC=C(O)C=C1 XLXSAKCOAKORKW-AQJXLSMYSA-N 0.000 description 2
- 229960002913 goserelin Drugs 0.000 description 2
- 230000036541 health Effects 0.000 description 2
- 229940088597 hormone Drugs 0.000 description 2
- 239000005556 hormone Substances 0.000 description 2
- 235000020256 human milk Nutrition 0.000 description 2
- 210000004251 human milk Anatomy 0.000 description 2
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 description 2
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 description 2
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 2
- 229960003943 hypromellose Drugs 0.000 description 2
- 238000003384 imaging method Methods 0.000 description 2
- 239000005414 inactive ingredient Substances 0.000 description 2
- 208000000509 infertility Diseases 0.000 description 2
- 230000036512 infertility Effects 0.000 description 2
- 231100000535 infertility Toxicity 0.000 description 2
- LDHBWEYLDHLIBQ-UHFFFAOYSA-M iron(3+);oxygen(2-);hydroxide;hydrate Chemical compound O.[OH-].[O-2].[Fe+3] LDHBWEYLDHLIBQ-UHFFFAOYSA-M 0.000 description 2
- 230000003907 kidney function Effects 0.000 description 2
- 208000019423 liver disease Diseases 0.000 description 2
- 230000007774 longterm Effects 0.000 description 2
- 235000004213 low-fat Nutrition 0.000 description 2
- 230000013011 mating Effects 0.000 description 2
- 229940126601 medicinal product Drugs 0.000 description 2
- 239000002207 metabolite Substances 0.000 description 2
- 230000009401 metastasis Effects 0.000 description 2
- 208000031225 myocardial ischemia Diseases 0.000 description 2
- 229940005483 opioid analgesics Drugs 0.000 description 2
- 230000001575 pathological effect Effects 0.000 description 2
- 239000008194 pharmaceutical composition Substances 0.000 description 2
- 230000036470 plasma concentration Effects 0.000 description 2
- 239000011591 potassium Substances 0.000 description 2
- 229910052700 potassium Inorganic materials 0.000 description 2
- 230000002035 prolonged effect Effects 0.000 description 2
- 235000018102 proteins Nutrition 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 230000002441 reversible effect Effects 0.000 description 2
- 239000000523 sample Substances 0.000 description 2
- 231100000847 severe hepatotoxicity Toxicity 0.000 description 2
- 230000008961 swelling Effects 0.000 description 2
- 229960000278 theophylline Drugs 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- 208000019206 urinary tract infection Diseases 0.000 description 2
- 210000002700 urine Anatomy 0.000 description 2
- 208000037911 visceral disease Diseases 0.000 description 2
- ZBVJFYPGLGEMIN-OYLNGHKZSA-N (2s)-n-[(2s)-1-[[(2s)-1-[[(2s)-1-[[(2s)-1-[[(2r)-1-[[(2s)-1-[[(2s)-1-[(2s)-2-[(2-amino-2-oxoethyl)carbamoyl]pyrrolidin-1-yl]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-(1h-indol-3-yl)-1-oxopropan-2-yl]amino]-3-( Chemical compound C1=CC=C2C(CC=3C4=CC=CC=C4C=C(C=3O)C(=O)O)=C(O)C(C(O)=O)=CC2=C1.C([C@@H](C(=O)N[C@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1[C@@H](CCC1)C(=O)NCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H]1NC(=O)CC1)C1=CC=C(O)C=C1 ZBVJFYPGLGEMIN-OYLNGHKZSA-N 0.000 description 1
- 208000003200 Adenoma Diseases 0.000 description 1
- 102000009027 Albumins Human genes 0.000 description 1
- 238000010953 Ames test Methods 0.000 description 1
- 231100000039 Ames test Toxicity 0.000 description 1
- 229940123407 Androgen receptor antagonist Drugs 0.000 description 1
- 206010002383 Angina Pectoris Diseases 0.000 description 1
- 206010002388 Angina unstable Diseases 0.000 description 1
- 206010003495 Aspermia Diseases 0.000 description 1
- 206010003662 Atrial flutter Diseases 0.000 description 1
- 206010003694 Atrophy Diseases 0.000 description 1
- 208000008035 Back Pain Diseases 0.000 description 1
- 102000004506 Blood Proteins Human genes 0.000 description 1
- 108010017384 Blood Proteins Proteins 0.000 description 1
- 206010049765 Bradyarrhythmia Diseases 0.000 description 1
- 206010058019 Cancer Pain Diseases 0.000 description 1
- 201000009030 Carcinoma Diseases 0.000 description 1
- 206010007617 Cardio-respiratory arrest Diseases 0.000 description 1
- 208000031229 Cardiomyopathies Diseases 0.000 description 1
- 108010078791 Carrier Proteins Proteins 0.000 description 1
- 208000014526 Conduction disease Diseases 0.000 description 1
- 206010010774 Constipation Diseases 0.000 description 1
- 208000034656 Contusions Diseases 0.000 description 1
- 229940124766 Cyp17 inhibitor Drugs 0.000 description 1
- 108010026925 Cytochrome P-450 CYP2C19 Proteins 0.000 description 1
- 108010000543 Cytochrome P-450 CYP2C9 Proteins 0.000 description 1
- 102000004328 Cytochrome P-450 CYP3A Human genes 0.000 description 1
- 102100029363 Cytochrome P450 2C19 Human genes 0.000 description 1
- 102100029358 Cytochrome P450 2C9 Human genes 0.000 description 1
- FMGSKLZLMKYGDP-UHFFFAOYSA-N Dehydroepiandrosterone Natural products C1C(O)CCC2(C)C3CCC(C)(C(CC4)=O)C4C3CC=C21 FMGSKLZLMKYGDP-UHFFFAOYSA-N 0.000 description 1
- 239000012848 Dextrorphan Substances 0.000 description 1
- 208000000059 Dyspnea Diseases 0.000 description 1
- 206010013975 Dyspnoeas Diseases 0.000 description 1
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 1
- 208000010201 Exanthema Diseases 0.000 description 1
- 208000037397 Fetal Weight Diseases 0.000 description 1
- 206010017076 Fracture Diseases 0.000 description 1
- 102000006771 Gonadotropins Human genes 0.000 description 1
- 108010086677 Gonadotropins Proteins 0.000 description 1
- 206010018735 Groin pain Diseases 0.000 description 1
- 206010061188 Haematotoxicity Diseases 0.000 description 1
- 238000010163 Hochberg test Methods 0.000 description 1
- 208000029422 Hypernatremia Diseases 0.000 description 1
- 208000029663 Hypophosphatemia Diseases 0.000 description 1
- 206010064919 Hypospermia Diseases 0.000 description 1
- 206010022998 Irritability Diseases 0.000 description 1
- 206010049694 Left Ventricular Dysfunction Diseases 0.000 description 1
- 201000004462 Leydig Cell Tumor Diseases 0.000 description 1
- 102000004317 Lyases Human genes 0.000 description 1
- 108090000856 Lyases Proteins 0.000 description 1
- 108010047230 Member 1 Subfamily B ATP Binding Cassette Transporter Proteins 0.000 description 1
- 208000036642 Metabolism and nutrition disease Diseases 0.000 description 1
- 206010027452 Metastases to bone Diseases 0.000 description 1
- 208000007101 Muscle Cramp Diseases 0.000 description 1
- 208000010428 Muscle Weakness Diseases 0.000 description 1
- 208000021642 Muscular disease Diseases 0.000 description 1
- 206010028372 Muscular weakness Diseases 0.000 description 1
- 206010028391 Musculoskeletal Pain Diseases 0.000 description 1
- 206010052904 Musculoskeletal stiffness Diseases 0.000 description 1
- 208000000112 Myalgia Diseases 0.000 description 1
- 201000009623 Myopathy Diseases 0.000 description 1
- 208000012902 Nervous system disease Diseases 0.000 description 1
- 231100000264 OECD 451 Carcinogenicity Study Toxicity 0.000 description 1
- 102000012404 Orosomucoid Human genes 0.000 description 1
- 108010061952 Orosomucoid Proteins 0.000 description 1
- CXOFVDLJLONNDW-UHFFFAOYSA-N Phenytoin Chemical compound N1C(=O)NC(=O)C1(C=1C=CC=CC=1)C1=CC=CC=C1 CXOFVDLJLONNDW-UHFFFAOYSA-N 0.000 description 1
- 206010036018 Pollakiuria Diseases 0.000 description 1
- ORNBQBCIOKFOEO-YQUGOWONSA-N Pregnenolone Natural products O=C(C)[C@@H]1[C@@]2(C)[C@H]([C@H]3[C@@H]([C@]4(C)C(=CC3)C[C@@H](O)CC4)CC2)CC1 ORNBQBCIOKFOEO-YQUGOWONSA-N 0.000 description 1
- 206010036790 Productive cough Diseases 0.000 description 1
- 206010037660 Pyrexia Diseases 0.000 description 1
- 208000033475 Renal and urinary disease Diseases 0.000 description 1
- 206010057190 Respiratory tract infections Diseases 0.000 description 1
- 206010039020 Rhabdomyolysis Diseases 0.000 description 1
- 108091006731 SLCO1B1 Proteins 0.000 description 1
- 108010071390 Serum Albumin Proteins 0.000 description 1
- 208000019498 Skin and subcutaneous tissue disease Diseases 0.000 description 1
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 description 1
- 208000026137 Soft tissue injury Diseases 0.000 description 1
- 102100027233 Solute carrier organic anion transporter family member 1B1 Human genes 0.000 description 1
- 208000005392 Spasm Diseases 0.000 description 1
- 101710163849 Steroid 17-alpha-hydroxylase/17,20 lyase Proteins 0.000 description 1
- 206010042434 Sudden death Diseases 0.000 description 1
- 208000003734 Supraventricular Tachycardia Diseases 0.000 description 1
- 208000001871 Tachycardia Diseases 0.000 description 1
- KLBQZWRITKRQQV-UHFFFAOYSA-N Thioridazine Chemical compound C12=CC(SC)=CC=C2SC2=CC=CC=C2N1CCC1CCCCN1C KLBQZWRITKRQQV-UHFFFAOYSA-N 0.000 description 1
- 208000007814 Unstable Angina Diseases 0.000 description 1
- 206010070488 Upper-airway cough syndrome Diseases 0.000 description 1
- 206010047281 Ventricular arrhythmia Diseases 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- ZWBTYMGEBZUQTK-PVLSIAFMSA-N [(7S,9E,11S,12R,13S,14R,15R,16R,17S,18S,19E,21Z)-2,15,17,32-tetrahydroxy-11-methoxy-3,7,12,14,16,18,22-heptamethyl-1'-(2-methylpropyl)-6,23-dioxospiro[8,33-dioxa-24,27,29-triazapentacyclo[23.6.1.14,7.05,31.026,30]tritriaconta-1(32),2,4,9,19,21,24,26,30-nonaene-28,4'-piperidine]-13-yl] acetate Chemical compound CO[C@H]1\C=C\O[C@@]2(C)Oc3c(C2=O)c2c4NC5(CCN(CC(C)C)CC5)N=c4c(=NC(=O)\C(C)=C/C=C/[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@@H]1C)c(O)c2c(O)c3C ZWBTYMGEBZUQTK-PVLSIAFMSA-N 0.000 description 1
- KPCZJLGGXRGYIE-UHFFFAOYSA-N [C]1=CC=CN=C1 Chemical group [C]1=CC=CN=C1 KPCZJLGGXRGYIE-UHFFFAOYSA-N 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- YBCVMFKXIKNREZ-UHFFFAOYSA-N acoh acetic acid Chemical compound CC(O)=O.CC(O)=O YBCVMFKXIKNREZ-UHFFFAOYSA-N 0.000 description 1
- 230000006978 adaptation Effects 0.000 description 1
- 208000025368 adrenal gland disease Diseases 0.000 description 1
- 208000026935 allergic disease Diseases 0.000 description 1
- 239000003936 androgen receptor antagonist Substances 0.000 description 1
- 239000005557 antagonist Substances 0.000 description 1
- 229940030495 antiandrogen sex hormone and modulator of the genital system Drugs 0.000 description 1
- 239000002246 antineoplastic agent Substances 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 125000003118 aryl group Chemical group 0.000 description 1
- 206010003668 atrial tachycardia Diseases 0.000 description 1
- 230000037444 atrophy Effects 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 230000036471 bradycardia Effects 0.000 description 1
- BMQGVNUXMIRLCK-OAGWZNDDSA-N cabazitaxel Chemical compound O([C@H]1[C@@H]2[C@]3(OC(C)=O)CO[C@@H]3C[C@@H]([C@]2(C(=O)[C@H](OC)C2=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)C=3C=CC=CC=3)C[C@]1(O)C2(C)C)C)OC)C(=O)C1=CC=CC=C1 BMQGVNUXMIRLCK-OAGWZNDDSA-N 0.000 description 1
- 229960001573 cabazitaxel Drugs 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- FFGPTBGBLSHEPO-UHFFFAOYSA-N carbamazepine Chemical compound C1=CC2=CC=CC=C2N(C(=O)N)C2=CC=CC=C21 FFGPTBGBLSHEPO-UHFFFAOYSA-N 0.000 description 1
- 229960000623 carbamazepine Drugs 0.000 description 1
- 206010007625 cardiogenic shock Diseases 0.000 description 1
- 230000001364 causal effect Effects 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 230000000973 chemotherapeutic effect Effects 0.000 description 1
- 238000009104 chemotherapy regimen Methods 0.000 description 1
- 210000000038 chest Anatomy 0.000 description 1
- 238000000546 chi-square test Methods 0.000 description 1
- 230000009850 completed effect Effects 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 230000001010 compromised effect Effects 0.000 description 1
- 229940124558 contraceptive agent Drugs 0.000 description 1
- 230000009519 contusion Effects 0.000 description 1
- 210000004246 corpus luteum Anatomy 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 238000009223 counseling Methods 0.000 description 1
- 230000001186 cumulative effect Effects 0.000 description 1
- 230000002559 cytogenic effect Effects 0.000 description 1
- 229940127089 cytotoxic agent Drugs 0.000 description 1
- 230000003111 delayed effect Effects 0.000 description 1
- 230000006866 deterioration Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 230000007673 developmental toxicity Effects 0.000 description 1
- 231100000415 developmental toxicity Toxicity 0.000 description 1
- JAQUASYNZVUNQP-PVAVHDDUSA-N dextrorphan Chemical compound C1C2=CC=C(O)C=C2[C@@]23CCN(C)[C@@H]1[C@H]2CCCC3 JAQUASYNZVUNQP-PVAVHDDUSA-N 0.000 description 1
- 229950006878 dextrorphan Drugs 0.000 description 1
- 230000004069 differentiation Effects 0.000 description 1
- 208000010643 digestive system disease Diseases 0.000 description 1
- 230000010339 dilation Effects 0.000 description 1
- 208000002173 dizziness Diseases 0.000 description 1
- 231100000673 dose–response relationship Toxicity 0.000 description 1
- 230000002526 effect on cardiovascular system Effects 0.000 description 1
- 210000002257 embryonic structure Anatomy 0.000 description 1
- 210000003743 erythrocyte Anatomy 0.000 description 1
- 230000005713 exacerbation Effects 0.000 description 1
- 201000005884 exanthem Diseases 0.000 description 1
- 230000029142 excretion Effects 0.000 description 1
- 235000020650 eye health related herbal supplements Nutrition 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 230000008175 fetal development Effects 0.000 description 1
- 231100001048 fetal toxicity Toxicity 0.000 description 1
- 230000027950 fever generation Effects 0.000 description 1
- 230000037406 food intake Effects 0.000 description 1
- 235000012631 food intake Nutrition 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 210000002149 gonad Anatomy 0.000 description 1
- 239000002622 gonadotropin Substances 0.000 description 1
- 230000012010 growth Effects 0.000 description 1
- 231100000226 haematotoxicity Toxicity 0.000 description 1
- 238000001631 haemodialysis Methods 0.000 description 1
- 230000007407 health benefit Effects 0.000 description 1
- 208000006750 hematuria Diseases 0.000 description 1
- 230000000322 hemodialysis Effects 0.000 description 1
- 208000027700 hepatic dysfunction Diseases 0.000 description 1
- 230000002440 hepatic effect Effects 0.000 description 1
- 208000024557 hepatobiliary disease Diseases 0.000 description 1
- 238000001794 hormone therapy Methods 0.000 description 1
- 206010020718 hyperplasia Diseases 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 206010022437 insomnia Diseases 0.000 description 1
- 201000004332 intermediate coronary syndrome Diseases 0.000 description 1
- 210000002570 interstitial cell Anatomy 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 230000001788 irregular Effects 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 208000017169 kidney disease Diseases 0.000 description 1
- 230000006651 lactation Effects 0.000 description 1
- 231100000225 lethality Toxicity 0.000 description 1
- 150000002634 lipophilic molecules Chemical class 0.000 description 1
- 210000001853 liver microsome Anatomy 0.000 description 1
- 230000007056 liver toxicity Effects 0.000 description 1
- 210000001165 lymph node Anatomy 0.000 description 1
- 208000010949 lymph node disease Diseases 0.000 description 1
- 210000004698 lymphocyte Anatomy 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 230000036210 malignancy Effects 0.000 description 1
- 210000005075 mammary gland Anatomy 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 231100001052 maternal toxicity Toxicity 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000001404 mediated effect Effects 0.000 description 1
- 238000002483 medication Methods 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
- 235000013336 milk Nutrition 0.000 description 1
- 239000008267 milk Substances 0.000 description 1
- 210000004080 milk Anatomy 0.000 description 1
- 231100000219 mutagenic Toxicity 0.000 description 1
- 230000003505 mutagenic effect Effects 0.000 description 1
- 201000009240 nasopharyngitis Diseases 0.000 description 1
- 238000009099 neoadjuvant therapy Methods 0.000 description 1
- 230000000955 neuroendocrine Effects 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 206010029446 nocturia Diseases 0.000 description 1
- 239000000820 nonprescription drug Substances 0.000 description 1
- 210000001331 nose Anatomy 0.000 description 1
- HGASFNYMVGEKTF-UHFFFAOYSA-N octan-1-ol;hydrate Chemical compound O.CCCCCCCCO HGASFNYMVGEKTF-UHFFFAOYSA-N 0.000 description 1
- 230000005305 organ development Effects 0.000 description 1
- 230000027758 ovulation cycle Effects 0.000 description 1
- 238000004806 packaging method and process Methods 0.000 description 1
- 238000011375 palliative radiation therapy Methods 0.000 description 1
- 210000003695 paranasal sinus Anatomy 0.000 description 1
- 239000004031 partial agonist Substances 0.000 description 1
- 238000005192 partition Methods 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 238000001050 pharmacotherapy Methods 0.000 description 1
- DDBREPKUVSBGFI-UHFFFAOYSA-N phenobarbital Chemical compound C=1C=CC=CC=1C1(CC)C(=O)NC(=O)NC1=O DDBREPKUVSBGFI-UHFFFAOYSA-N 0.000 description 1
- 229960002695 phenobarbital Drugs 0.000 description 1
- 229960002036 phenytoin Drugs 0.000 description 1
- 208000017402 pituitary gland disease Diseases 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 229960002847 prasterone Drugs 0.000 description 1
- 239000002243 precursor Substances 0.000 description 1
- 229940102542 prednisone 5 mg Drugs 0.000 description 1
- 229960000249 pregnenolone Drugs 0.000 description 1
- ORNBQBCIOKFOEO-QGVNFLHTSA-N pregnenolone Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](C(=O)C)[C@@]1(C)CC2 ORNBQBCIOKFOEO-QGVNFLHTSA-N 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 229940002612 prodrug Drugs 0.000 description 1
- 239000000651 prodrug Substances 0.000 description 1
- 229960003387 progesterone Drugs 0.000 description 1
- 239000000186 progesterone Substances 0.000 description 1
- 238000004393 prognosis Methods 0.000 description 1
- 230000000069 prophylactic effect Effects 0.000 description 1
- 238000011321 prophylaxis Methods 0.000 description 1
- 238000011471 prostatectomy Methods 0.000 description 1
- 208000020016 psychiatric disease Diseases 0.000 description 1
- 230000002285 radioactive effect Effects 0.000 description 1
- 238000007409 radiographic assessment Methods 0.000 description 1
- 206010037844 rash Diseases 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 239000003488 releasing hormone Substances 0.000 description 1
- 231100000191 repeated dose toxicity Toxicity 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000000241 respiratory effect Effects 0.000 description 1
- 229960000885 rifabutin Drugs 0.000 description 1
- WDZCUPBHRAEYDL-GZAUEHORSA-N rifapentine Chemical compound O([C@](C1=O)(C)O/C=C/[C@@H]([C@H]([C@@H](OC(C)=O)[C@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@@H](C)\C=C\C=C(C)/C(=O)NC=2C(O)=C3C(O)=C4C)C)OC)C4=C1C3=C(O)C=2\C=N\N(CC1)CCN1C1CCCC1 WDZCUPBHRAEYDL-GZAUEHORSA-N 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 230000001568 sexual effect Effects 0.000 description 1
- 230000011664 signaling Effects 0.000 description 1
- 231100000161 signs of toxicity Toxicity 0.000 description 1
- 208000017520 skin disease Diseases 0.000 description 1
- 231100000046 skin rash Toxicity 0.000 description 1
- 210000004872 soft tissue Anatomy 0.000 description 1
- 229940124547 specific antidotes Drugs 0.000 description 1
- 230000019100 sperm motility Effects 0.000 description 1
- 229960002256 spironolactone Drugs 0.000 description 1
- LXMSZDCAJNLERA-ZHYRCANASA-N spironolactone Chemical compound C([C@@H]1[C@]2(C)CC[C@@H]3[C@@]4(C)CCC(=O)C=C4C[C@H]([C@@H]13)SC(=O)C)C[C@@]21CCC(=O)O1 LXMSZDCAJNLERA-ZHYRCANASA-N 0.000 description 1
- 238000007619 statistical method Methods 0.000 description 1
- 150000003431 steroids Chemical class 0.000 description 1
- 238000013517 stratification Methods 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 230000003319 supportive effect Effects 0.000 description 1
- 206010042772 syncope Diseases 0.000 description 1
- 238000009121 systemic therapy Methods 0.000 description 1
- 230000006794 tachycardia Effects 0.000 description 1
- 230000002381 testicular Effects 0.000 description 1
- 229960002784 thioridazine Drugs 0.000 description 1
- 201000002931 third-degree atrioventricular block Diseases 0.000 description 1
- 210000000115 thoracic cavity Anatomy 0.000 description 1
- 230000003867 tiredness Effects 0.000 description 1
- 208000016255 tiredness Diseases 0.000 description 1
- 231100000820 toxicity test Toxicity 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 238000011824 transgenic rat model Methods 0.000 description 1
- 150000003626 triacylglycerols Chemical class 0.000 description 1
- 229960000294 triptorelin pamoate Drugs 0.000 description 1
- 230000004614 tumor growth Effects 0.000 description 1
- 230000004222 uncontrolled growth Effects 0.000 description 1
- 230000002485 urinary effect Effects 0.000 description 1
- 208000022934 urinary frequency Diseases 0.000 description 1
- 230000036318 urination frequency Effects 0.000 description 1
- 230000002861 ventricular Effects 0.000 description 1
- 206010047302 ventricular tachycardia Diseases 0.000 description 1
- 210000001835 viscera Anatomy 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000019195 vitamin supplement Nutrition 0.000 description 1
- 238000004383 yellowing Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4406—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 3, e.g. zimeldine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
- G16H10/00—ICT specially adapted for the handling or processing of patient-related medical or healthcare data
- G16H10/60—ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Medical Informatics (AREA)
- Primary Health Care (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762570781P | 2017-10-11 | 2017-10-11 | |
| US62/570,781 | 2017-10-11 | ||
| PCT/US2018/017438 WO2019074536A1 (en) | 2017-10-11 | 2018-02-08 | METHODS OF TREATING PROSTATE CANCER BY ADMINISTERING ABIRATERONE ACETATE AND PREDNISONE WITH ANDROGENIC SEPARATION THERAPY |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112020007090A2 true BR112020007090A2 (pt) | 2020-09-24 |
Family
ID=61283312
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112020007090-4A BR112020007090A2 (pt) | 2017-10-11 | 2018-02-08 | métodos de tratamento de câncer de próstata mediante a administração de acetato de abiraterona mais prednisona com terapia de supressão androgênica |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US20190105332A1 (enExample) |
| EP (1) | EP3694604A1 (enExample) |
| JP (1) | JP2020536903A (enExample) |
| KR (1) | KR20200068689A (enExample) |
| CN (1) | CN111542373A (enExample) |
| AU (1) | AU2018347804A1 (enExample) |
| BR (1) | BR112020007090A2 (enExample) |
| CA (1) | CA3077678A1 (enExample) |
| EA (1) | EA202090916A1 (enExample) |
| IL (1) | IL273826A (enExample) |
| JO (1) | JOP20200072A1 (enExample) |
| MA (1) | MA50341A (enExample) |
| MX (1) | MX2020003830A (enExample) |
| PH (1) | PH12020550151A1 (enExample) |
| UA (1) | UA124865C2 (enExample) |
| WO (1) | WO2019074536A1 (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RS66574B1 (sr) | 2016-07-29 | 2025-03-31 | Janssen Pharmaceutica Nv | Niraparib za upotrebu u postupku lečenja raka prostate |
| US10702508B2 (en) | 2017-10-16 | 2020-07-07 | Aragon Pharmaceuticals, Inc. | Anti-androgens for the treatment of non-metastatic castration-resistant prostate cancer |
| MX2022014003A (es) * | 2020-05-08 | 2022-11-30 | Janssen Pharmaceutica Nv | Tratamientos del cancer de prostata con combinaciones de acetato de abiraterona y niraparib. |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102898495B (zh) * | 2012-11-12 | 2014-11-26 | 浙江神洲药业有限公司 | 醋酸阿比特龙酯的制备方法 |
-
2018
- 2018-02-08 US US15/891,974 patent/US20190105332A1/en not_active Abandoned
- 2018-02-08 MA MA050341A patent/MA50341A/fr unknown
- 2018-02-08 JP JP2020520290A patent/JP2020536903A/ja active Pending
- 2018-02-08 BR BR112020007090-4A patent/BR112020007090A2/pt not_active IP Right Cessation
- 2018-02-08 CN CN201880079993.2A patent/CN111542373A/zh active Pending
- 2018-02-08 UA UAA202002743A patent/UA124865C2/uk unknown
- 2018-02-08 KR KR1020207012842A patent/KR20200068689A/ko not_active Ceased
- 2018-02-08 AU AU2018347804A patent/AU2018347804A1/en not_active Abandoned
- 2018-02-08 EA EA202090916A patent/EA202090916A1/ru unknown
- 2018-02-08 EP EP18707472.9A patent/EP3694604A1/en not_active Withdrawn
- 2018-02-08 CA CA3077678A patent/CA3077678A1/en active Pending
- 2018-02-08 JO JOP/2020/0072A patent/JOP20200072A1/ar unknown
- 2018-02-08 WO PCT/US2018/017438 patent/WO2019074536A1/en not_active Ceased
- 2018-02-08 MX MX2020003830A patent/MX2020003830A/es unknown
-
2019
- 2019-11-05 US US16/674,323 patent/US20200069704A1/en not_active Abandoned
-
2020
- 2020-03-26 PH PH12020550151A patent/PH12020550151A1/en unknown
- 2020-04-06 IL IL273826A patent/IL273826A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN111542373A (zh) | 2020-08-14 |
| CA3077678A1 (en) | 2019-04-18 |
| PH12020550151A1 (en) | 2021-02-08 |
| EP3694604A1 (en) | 2020-08-19 |
| IL273826A (en) | 2020-05-31 |
| AU2018347804A1 (en) | 2020-04-16 |
| JP2020536903A (ja) | 2020-12-17 |
| MA50341A (fr) | 2020-08-19 |
| MX2020003830A (es) | 2020-11-06 |
| US20200069704A1 (en) | 2020-03-05 |
| KR20200068689A (ko) | 2020-06-15 |
| EA202090916A1 (ru) | 2020-12-11 |
| UA124865C2 (uk) | 2021-12-01 |
| WO2019074536A1 (en) | 2019-04-18 |
| JOP20200072A1 (ar) | 2020-04-29 |
| US20190105332A1 (en) | 2019-04-11 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US11160796B2 (en) | Anti-androgens for the treatment of non-metastatic castration-resistant prostate cancer | |
| JP6595024B2 (ja) | Ｂ−Ｒａｆ阻害薬、ＥＧＦＲ阻害薬及び場合によってはＰＩ３Ｋ−α阻害薬を含む組合せ医薬 | |
| US20190262330A1 (en) | Method of Treating Hepatocellular Carcinoma Using N-(4-(6,7-dimethoxyquinolin-4-yloxy)phenyl)-N′-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide, (2S)-hydroxybutanedioate | |
| CN113365623B (zh) | 用于治疗转移性去势敏感性前列腺癌的抗雄激素 | |
| BR112020007090A2 (pt) | métodos de tratamento de câncer de próstata mediante a administração de acetato de abiraterona mais prednisona com terapia de supressão androgênica | |
| TW202302084A (zh) | 以安森司坦和帕博西尼治療乳癌 | |
| US20250177414A1 (en) | Combination therapies for treatment of breast cancer | |
| WO2025027138A9 (en) | Combination of niraparib and abiraterone for use in the treatment of metastatic castration-resistant prostate cancer | |
| CN117580572A (zh) | 用安森司坦和帕博西尼治疗乳腺癌 | |
| WO2023209555A1 (en) | Approved drug products and methods for treating prostate cancer | |
| HK40116445A (en) | Anti-androgens for the treatment of non-metastatic castration-resistant prostate cancer | |
| TO | PREVENT RECURRENCE1, 2 | |
| EA050385B1 (ru) | Антиандрогены для лечения неметастатического кастрационно-резистентного рака предстательной железы | |
| WO2014193589A1 (en) | Cancer treatment method |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B350 | Update of information on the portal [chapter 15.35 patent gazette] | ||
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 6A ANUIDADE. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2761 DE 05-12-2023 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |