JP2020536121A - 駆出率が保持された心不全を治療する方法 - Google Patents

駆出率が保持された心不全を治療する方法 Download PDF

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Publication number
JP2020536121A
JP2020536121A JP2020539153A JP2020539153A JP2020536121A JP 2020536121 A JP2020536121 A JP 2020536121A JP 2020539153 A JP2020539153 A JP 2020539153A JP 2020539153 A JP2020539153 A JP 2020539153A JP 2020536121 A JP2020536121 A JP 2020536121A
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imegrimin
patient
day
administered
hfpef
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JP2020536121A5 (enExample
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アラクウ−ボゼック ソフィー
アラクウ−ボゼック ソフィー
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Poxel SA
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Poxel SA
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Hospice & Palliative Care (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2020539153A 2017-10-02 2018-10-02 駆出率が保持された心不全を治療する方法 Pending JP2020536121A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762566668P 2017-10-02 2017-10-02
US62/566,668 2017-10-02
PCT/IB2018/057648 WO2019069230A1 (en) 2017-10-02 2018-10-02 METHODS OF TREATING CARDIAC INSUFFICIENCY WITH PRESERVED EJECTION FRACTION

Publications (2)

Publication Number Publication Date
JP2020536121A true JP2020536121A (ja) 2020-12-10
JP2020536121A5 JP2020536121A5 (enExample) 2021-12-02

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JP2020539153A Pending JP2020536121A (ja) 2017-10-02 2018-10-02 駆出率が保持された心不全を治療する方法

Country Status (12)

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US (1) US11617754B2 (enExample)
EP (1) EP3691650A1 (enExample)
JP (1) JP2020536121A (enExample)
KR (1) KR20200102982A (enExample)
CN (1) CN111163782A (enExample)
BR (1) BR112020006472A2 (enExample)
CA (1) CA3078163A1 (enExample)
IL (1) IL273723A (enExample)
MX (1) MX2020003243A (enExample)
TW (1) TW201924689A (enExample)
WO (1) WO2019069230A1 (enExample)
ZA (1) ZA202002292B (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3691650A1 (en) 2017-10-02 2020-08-12 Poxel Methods of treating heart failure with preserved ejection fraction
MY203360A (en) 2018-06-06 2024-06-26 Metavant Sciences Gmbh Methods of treating subjects having diabetes with chronic kidney disease
CA3103324A1 (en) 2018-06-14 2019-12-19 Poxel Film-coated tablet comprising a triazine derivative for use in the treatment of diabetes
CN121287190A (zh) * 2021-09-07 2026-01-09 深圳迈瑞生物医疗电子股份有限公司 一种超声波数据的处理方法、成像装置
CN116440075B (zh) * 2023-06-01 2025-05-06 苏州中化药品工业有限公司 一种干混悬剂及其制备方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2017507956A (ja) * 2014-02-28 2017-03-23 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｄｐｐ−４阻害薬の医学的使用

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FR2804113B1 (fr) 2000-01-26 2004-06-18 Lipha Derives animes de dihydro-1,3,5-triazine et leurs applications en therapeutique
FR2853650B1 (fr) 2003-04-10 2006-07-07 Merck Sante Sas Procede de dedoublement d'amines utiles pour le traitement de desordres associes au syndrome d'insulino-resistance
FR2896159B1 (fr) 2006-01-13 2008-09-12 Merck Sante Soc Par Actions Si Combinaison de derives de triazine et d'agents sensibilisateurs a l'insuline.
FR2896161B1 (fr) 2006-01-13 2008-04-04 Merck Sante Soc Par Actions Si Utilisation de derives de triazines pour fabriquer un medicament ayant un effet cicatrisant ou angiogenique.
FR2896157B1 (fr) 2006-01-13 2008-09-12 Merck Sante Soc Par Actions Si Combinaison de derives de triazine et d'agents de stimulation de secretion d'insuline.
DE102008007314A1 (de) 2008-02-02 2009-08-06 Merck Patent Gmbh Verfahren zur Herstellung von 3,6-Dihydro-1,3,5-triazinderivaten
US20110124860A1 (en) 2008-05-23 2011-05-26 Aubourg Stephanie Process for the synthesis of 3,6-dihydro-1,3,5-triazine derivatives
SI2344435T1 (sl) 2008-07-29 2016-05-31 Poxel Proces izolacije enantiomernih spojin iz enantiomernih mešanic s kristalizacijo nadzorovano z velikostjo delcev
ES2530223T3 (es) 2008-12-12 2015-02-27 Poxel S.A.S. Combinación de insulina con derivados de triazina y su uso para tratar la diabetes
JP5485292B2 (ja) 2008-12-12 2014-05-07 ポクセル・エスアーエス Ａｍｐｋ活性に関連する疾患を処置するためのテトラヒドロトリアジン化合物
US8742102B2 (en) 2009-03-26 2014-06-03 Poxel Process for enantiomeric separation of racemic dihydro-1,3,5 triazines via preferential crystallization
FR2948027A1 (fr) 2009-07-17 2011-01-21 Merck Sante Sas Derives amines de dihydro-1,3,5-triazine pour leur utilisation dans le traitement des maladies associees a une ischemie et/ou une reperfusion
WO2011154496A1 (en) 2010-06-09 2011-12-15 Poxel Treatment of type 1 diabetes
TWI436768B (zh) * 2010-06-09 2014-05-11 Poxel 第２型糖尿病之治療
EP2646422B1 (en) 2010-12-01 2015-07-08 Poxel Separation of triazine derivatives enantiomers using tartaric acid
US9211263B2 (en) 2012-01-06 2015-12-15 Elcelyx Therapeutics, Inc. Compositions and methods of treating metabolic disorders
WO2014160524A1 (en) * 2013-03-14 2014-10-02 The Trustees Of The University Of Pennsylvania Cardio- metabolic and cascular effects of glp-1 metabolites
CA2812519A1 (en) 2013-04-05 2014-10-05 Boehringer Ingelheim International Gmbh Pharmaceutical composition, methods for treating and uses thereof
WO2016077126A1 (en) 2014-11-10 2016-05-19 Merck Sharp & Dohme Corp. Sglt-2 inhibitors for treating metabolic disorders in patients with renal impairment or chronic kidney disease
KR20230111262A (ko) * 2016-03-16 2023-07-25 베링거 인겔하임 인터내셔날 게엠베하 엠파글리플로진을 포함하는 약제학적 조성물 및 이의용도
EP3691650A1 (en) 2017-10-02 2020-08-12 Poxel Methods of treating heart failure with preserved ejection fraction
MY203360A (en) 2018-06-06 2024-06-26 Metavant Sciences Gmbh Methods of treating subjects having diabetes with chronic kidney disease

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2017507956A (ja) * 2014-02-28 2017-03-23 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｄｐｐ−４阻害薬の医学的使用

Non-Patent Citations (3)

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Title
J CLIN MED RES, vol. 10, no. 11, JPN6022030872, 2018, pages 799 - 805, ISSN: 0004838526 *
LACHAUX M; ET AL: "P577 | BENCH: SHORT- AND LONG-TERM IMEGLIMIN TREATMENT REDUCES METABOLIC SYNDROME-RELATED DIABETIC C", EUROPEAN HEART JOURNAL, vol. VOL:38, NR:SUPPL1, JPN5021001821, 29 August 2017 (2017-08-29), GB, pages 101, ISSN: 0005043412 *
LACHAUX, MARIANNE ET AL.: "Short- and long-term imeglimin treatment reduces metabolic syndrome-related diabetic cardiomyopathy", EASD (EUROPEAN ASSOCIATION FOR THE STUDY OF DIABETES) [ONLINE], JPN6022030875, August 2017 (2017-08-01), ISSN: 0005043413 *

Also Published As

Publication number Publication date
EP3691650A1 (en) 2020-08-12
CN111163782A (zh) 2020-05-15
IL273723A (en) 2020-05-31
US20200316078A1 (en) 2020-10-08
CA3078163A1 (en) 2019-04-11
US11617754B2 (en) 2023-04-04
KR20200102982A (ko) 2020-09-01
BR112020006472A2 (pt) 2020-10-06
MX2020003243A (es) 2020-09-18
WO2019069230A1 (en) 2019-04-11
TW201924689A (zh) 2019-07-01
ZA202002292B (en) 2022-12-21

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