JP2020535448A5 - - Google Patents
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- JP2020535448A5 JP2020535448A5 JP2020538771A JP2020538771A JP2020535448A5 JP 2020535448 A5 JP2020535448 A5 JP 2020535448A5 JP 2020538771 A JP2020538771 A JP 2020538771A JP 2020538771 A JP2020538771 A JP 2020538771A JP 2020535448 A5 JP2020535448 A5 JP 2020535448A5
- Authority
- JP
- Japan
- Prior art keywords
- poly
- biological sample
- subject
- ran
- optionally
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000012472 biological sample Substances 0.000 claims 15
- 238000000034 method Methods 0.000 claims 15
- 102000005912 ran GTP Binding Protein Human genes 0.000 claims 11
- 108010005597 ran GTP Binding Protein Proteins 0.000 claims 11
- 238000003556 assay Methods 0.000 claims 8
- 238000004020 luminiscence type Methods 0.000 claims 7
- 239000003814 drug Substances 0.000 claims 6
- 230000036039 immunity Effects 0.000 claims 6
- 229940124597 therapeutic agent Drugs 0.000 claims 6
- 108090000623 proteins and genes Proteins 0.000 claims 5
- 239000000523 sample Substances 0.000 claims 4
- 239000002253 acid Substances 0.000 claims 3
- 102000004169 proteins and genes Human genes 0.000 claims 3
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims 2
- 201000011240 Frontotemporal dementia Diseases 0.000 claims 2
- 208000023105 Huntington disease Diseases 0.000 claims 2
- 108091034117 Oligonucleotide Proteins 0.000 claims 2
- 206010002026 amyotrophic lateral sclerosis Diseases 0.000 claims 2
- 239000000074 antisense oligonucleotide Substances 0.000 claims 2
- 238000012230 antisense oligonucleotides Methods 0.000 claims 2
- XZWYZXLIPXDOLR-UHFFFAOYSA-N metformin Chemical group CN(C)C(=N)NC(N)=N XZWYZXLIPXDOLR-UHFFFAOYSA-N 0.000 claims 2
- 201000003498 spinocerebellar ataxia type 36 Diseases 0.000 claims 2
- 102000040650 (ribonucleotides)n+m Human genes 0.000 claims 1
- 108091023037 Aptamer Proteins 0.000 claims 1
- 108091026821 Artificial microRNA Proteins 0.000 claims 1
- 108020004459 Small interfering RNA Proteins 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- 210000004899 c-terminal region Anatomy 0.000 claims 1
- 238000001514 detection method Methods 0.000 claims 1
- 239000012634 fragment Substances 0.000 claims 1
- 230000003053 immunization Effects 0.000 claims 1
- 238000002649 immunization Methods 0.000 claims 1
- 230000002452 interceptive effect Effects 0.000 claims 1
- 229960003105 metformin Drugs 0.000 claims 1
- 108091070501 miRNA Proteins 0.000 claims 1
- 239000002679 microRNA Substances 0.000 claims 1
- 230000003285 pharmacodynamic effect Effects 0.000 claims 1
- 150000003384 small molecules Chemical group 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023150846A JP2023174663A (ja) | 2017-09-25 | 2023-09-19 | Ｒａｎタンパク質の検出のための免疫アッセイ |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762563009P | 2017-09-25 | 2017-09-25 | |
| US62/563,009 | 2017-09-25 | ||
| PCT/US2018/052745 WO2019060918A1 (en) | 2017-09-25 | 2018-09-25 | IMMUNOLOGICAL ASSAYS FOR DETECTION OF RAN PROTEINS |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023150846A Division JP2023174663A (ja) | 2017-09-25 | 2023-09-19 | Ｒａｎタンパク質の検出のための免疫アッセイ |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2020535448A JP2020535448A (ja) | 2020-12-03 |
| JP2020535448A5 true JP2020535448A5 (OSRAM) | 2021-11-04 |
Family
ID=65811531
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020538771A Pending JP2020535448A (ja) | 2017-09-25 | 2018-09-25 | Ｒａｎタンパク質の検出のための免役アッセイ |
| JP2023150846A Pending JP2023174663A (ja) | 2017-09-25 | 2023-09-19 | Ｒａｎタンパク質の検出のための免疫アッセイ |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023150846A Pending JP2023174663A (ja) | 2017-09-25 | 2023-09-19 | Ｒａｎタンパク質の検出のための免疫アッセイ |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP3688020A4 (OSRAM) |
| JP (2) | JP2020535448A (OSRAM) |
| AU (2) | AU2018338451A1 (OSRAM) |
| CA (1) | CA3075908A1 (OSRAM) |
| WO (1) | WO2019060918A1 (OSRAM) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6628285B2 (ja) | 2013-03-14 | 2020-01-08 | ユニバーシティ オブ フロリダ リサーチ ファンデーション インコーポレーティッド | Ａｌｓ関連ジアミノ酸リピート含有タンパク質 |
| WO2016196324A1 (en) | 2015-05-29 | 2016-12-08 | University Of Floridia Research Foundation, Inc. | Methods for diagnosing huntington's disease |
| EP3440100A4 (en) | 2016-04-04 | 2020-01-22 | University of Florida Research Foundation, Incorporated | HANDLING EIF3 TO MODULATE A NON-ATG TRANSLATION ASSOCIATED WITH A REPETITION (RAN) |
| US11345911B2 (en) | 2017-04-17 | 2022-05-31 | University Of Florida Research Foundation, Incorporated | Regulation of RAN translation by PKR and eIF2A-P pathways |
| EP3688021A4 (en) | 2017-09-26 | 2021-12-29 | University of Florida Research Foundation, Incorporated | Use of metformin and analogs thereof to reduce ran protein levels in the treatment of neurological disorders |
| CA3145291A1 (en) * | 2019-07-05 | 2021-01-14 | University Of Florida Research Foundation, Incorporated | Methods for treating ran protein-associated neurological diseases |
| US12436154B2 (en) | 2019-09-20 | 2025-10-07 | University Of Florida Research Foundation, Incorporated | Detection of antibodies against RAN proteins from serum and tissue lysates |
| US20240069039A1 (en) * | 2019-10-10 | 2024-02-29 | University Of Florida Research Foundation, Incorporated | Ran proteins as biomarkers in cag/ctg expansion disorders |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT2082225E (pt) * | 2006-09-20 | 2014-04-10 | Univ Belfast | Método para determinar se uma célula tumoral tem potencial invasivo e/ou metastático e agentes moduladores de transformação maligna |
| BR112013013354A2 (pt) * | 2010-11-30 | 2020-10-06 | Chugai Seiyaku Kabushiki Kaisha | molécula de ligação ao antígeno capaz de se ligar a uma pluralidade de moléculas de antígeno repetidamente |
| JP6628285B2 (ja) * | 2013-03-14 | 2020-01-08 | ユニバーシティ オブ フロリダ リサーチ ファンデーション インコーポレーティッド | Ａｌｓ関連ジアミノ酸リピート含有タンパク質 |
| US20170292129A1 (en) * | 2014-08-13 | 2017-10-12 | The Scripps Research Institute | Treatment of c9ftd/als by targeting rna expanded repeat sequences |
| JP6508996B2 (ja) * | 2015-03-24 | 2019-05-08 | 東ソー株式会社 | β−ＡＮＰによる心不全の検出方法 |
| AU2016333538B2 (en) * | 2015-10-02 | 2022-03-31 | Julius-Maximilians-Universität Würzburg | GDF-15 as a diagnostic marker to predict the clinical outcome of a treatment with immune checkpoint blockers |
-
2018
- 2018-09-25 AU AU2018338451A patent/AU2018338451A1/en not_active Abandoned
- 2018-09-25 JP JP2020538771A patent/JP2020535448A/ja active Pending
- 2018-09-25 EP EP18859783.5A patent/EP3688020A4/en active Pending
- 2018-09-25 CA CA3075908A patent/CA3075908A1/en active Pending
- 2018-09-25 WO PCT/US2018/052745 patent/WO2019060918A1/en not_active Ceased
-
2023
- 2023-09-19 JP JP2023150846A patent/JP2023174663A/ja active Pending
-
2024
- 2024-09-04 AU AU2024219412A patent/AU2024219412A1/en active Pending
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