JP2020535448A - Ｒａｎタンパク質の検出のための免役アッセイ - Google Patents

Ｒａｎタンパク質の検出のための免役アッセイ Download PDF

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Publication number
JP2020535448A
JP2020535448A JP2020538771A JP2020538771A JP2020535448A JP 2020535448 A JP2020535448 A JP 2020535448A JP 2020538771 A JP2020538771 A JP 2020538771A JP 2020538771 A JP2020538771 A JP 2020538771A JP 2020535448 A JP2020535448 A JP 2020535448A
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ran
poly
subject
antibody
sample
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JP2020535448A5 (OSRAM
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ラヌム，ラウラ
グエン，リエン
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University of Florida Research Foundation Inc
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University of Florida Research Foundation Inc
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Priority to JP2023150846A priority Critical patent/JP2023174663A/ja
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/76—Chemiluminescence; Bioluminescence
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2458/00—Labels used in chemical analysis of biological material
    • G01N2458/30—Electrochemically active labels
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • Neurology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Neurosurgery (AREA)
  • Food Science & Technology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Plasma & Fusion (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
JP2020538771A 2017-09-25 2018-09-25 Ｒａｎタンパク質の検出のための免役アッセイ Pending JP2020535448A (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2023150846A JP2023174663A (ja) 2017-09-25 2023-09-19 Ｒａｎタンパク質の検出のための免疫アッセイ

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762563009P 2017-09-25 2017-09-25
US62/563,009 2017-09-25
PCT/US2018/052745 WO2019060918A1 (en) 2017-09-25 2018-09-25 IMMUNOLOGICAL ASSAYS FOR DETECTION OF RAN PROTEINS

Related Child Applications (1)

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JP2023150846A Division JP2023174663A (ja) 2017-09-25 2023-09-19 Ｒａｎタンパク質の検出のための免疫アッセイ

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JP2020535448A true JP2020535448A (ja) 2020-12-03
JP2020535448A5 JP2020535448A5 (OSRAM) 2021-11-04

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Family Applications (2)

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JP2020538771A Pending JP2020535448A (ja) 2017-09-25 2018-09-25 Ｒａｎタンパク質の検出のための免役アッセイ
JP2023150846A Pending JP2023174663A (ja) 2017-09-25 2023-09-19 Ｒａｎタンパク質の検出のための免疫アッセイ

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Country Link
US (1) US12504380B2 (OSRAM)
EP (1) EP3688020A4 (OSRAM)
JP (2) JP2020535448A (OSRAM)
AU (2) AU2018338451A1 (OSRAM)
CA (1) CA3075908A1 (OSRAM)
WO (1) WO2019060918A1 (OSRAM)

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CA3019847A1 (en) 2016-04-04 2017-10-12 University Of Florida Research Foundation, Incorporated Manipulation of eif3 to modulate repeat associated non-atg (ran) translation
AU2018255293B2 (en) 2017-04-17 2024-03-07 University Of Florida Research Foundation, Incorporated Regulation of RAN translation by PKR and eIF2a-P pathways
AU2018338451A1 (en) 2017-09-25 2020-04-02 University Of Florida Research Foundation, Incorporated Immunoassays for detection of RAN proteins
JP7350337B2 (ja) 2017-09-26 2023-09-26 ユニバーシティー オブ フロリダ リサーチ ファンデーション， インク． 神経障害の処置においてｒａｎタンパク質レベルを低下させるためのメトホルミンおよびそのアナログの使用
WO2021007110A1 (en) * 2019-07-05 2021-01-14 University Of Florida Research Foundation, Incorporated Methods for treating ran protein-associated neurological diseases
CA3154741A1 (en) * 2019-09-20 2021-03-25 University Of Florida Research Foundation, Incorporated Detection of antibodies against ran proteins from serum and tissue lysates
WO2021072187A2 (en) * 2019-10-10 2021-04-15 University Of Florida Research Foundation, Incorporated Ran proteins as biomarkers in cag/ctg expansion disorders
US20250164489A1 (en) * 2022-02-28 2025-05-22 University Of Florida Research Foundation, Incorporated Ran proteins in sporadic amyotrophic lateral sclerosis

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Publication number Publication date
WO2019060918A8 (en) 2019-04-18
EP3688020A4 (en) 2021-07-14
AU2024219412A1 (en) 2024-09-26
JP2023174663A (ja) 2023-12-08
CA3075908A1 (en) 2019-03-28
EP3688020A1 (en) 2020-08-05
US20200232925A1 (en) 2020-07-23
WO2019060918A1 (en) 2019-03-28
AU2018338451A1 (en) 2020-04-02
US12504380B2 (en) 2025-12-23

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