JP2020534270A - １９−ノルｃ３，３−二置換ｃ２１−ｎ−ピラゾリルステロイドおよびその使用方法 - Google Patents

１９−ノルｃ３，３−二置換ｃ２１−ｎ−ピラゾリルステロイドおよびその使用方法 Download PDF

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JP2020534270A
JP2020534270A JP2020514950A JP2020514950A JP2020534270A JP 2020534270 A JP2020534270 A JP 2020534270A JP 2020514950 A JP2020514950 A JP 2020514950A JP 2020514950 A JP2020514950 A JP 2020514950A JP 2020534270 A JP2020534270 A JP 2020534270A
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sleep
compound
subject
subjects
administered
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JP2020534270A5 (https=
Inventor
ジェイムズ ジェイ． ドハーティ，
ジェイムズ ジェイ． ドハーティ，
スティーブン ジェイ ケインズ，
スティーブン ジェイ ケインズ，
ジェフリー エム． ジョナス，
ジェフリー エム． ジョナス，
インダージット カウル，
インダージット カウル，
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Sage Therapeutics LLC
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Sage Therapeutics LLC
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Publication of JP2020534270A publication Critical patent/JP2020534270A/ja
Publication of JP2020534270A5 publication Critical patent/JP2020534270A5/ja
Priority to JP2023008782A priority Critical patent/JP2023038310A/ja
Priority to JP2024091642A priority patent/JP2024107137A/ja
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4816—Wall or shell material
    • A61K9/4825—Proteins, e.g. gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Anesthesiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP2020514950A 2017-09-14 2018-09-14 １９−ノルｃ３，３−二置換ｃ２１−ｎ−ピラゾリルステロイドおよびその使用方法 Pending JP2020534270A (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2023008782A JP2023038310A (ja) 2017-09-14 2023-01-24 １９－ノルｃ３，３－二置換ｃ２１－ｎ－ピラゾリルステロイドおよびその使用方法
JP2024091642A JP2024107137A (ja) 2017-09-14 2024-06-05 １９－ノルｃ３，３－二置換ｃ２１－ｎ－ピラゾリルステロイドおよびその使用方法

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US201762558703P 2017-09-14 2017-09-14
US62/558,703 2017-09-14
US201862624678P 2018-01-31 2018-01-31
US201862624680P 2018-01-31 2018-01-31
US62/624,678 2018-01-31
US62/624,680 2018-01-31
US201862653189P 2018-04-05 2018-04-05
US62/653,189 2018-04-05
PCT/US2018/051048 WO2019055764A1 (en) 2017-09-14 2018-09-14 C21-N-PYRAZOLYL C3,3-DISUBSTITUTED STEROID 19 NOR, AND METHODS OF USING THE SAME

Related Child Applications (1)

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JP2023008782A Division JP2023038310A (ja) 2017-09-14 2023-01-24 １９－ノルｃ３，３－二置換ｃ２１－ｎ－ピラゾリルステロイドおよびその使用方法

Publications (2)

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JP2020534270A true JP2020534270A (ja) 2020-11-26
JP2020534270A5 JP2020534270A5 (https=) 2021-10-28

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JP2020514950A Pending JP2020534270A (ja) 2017-09-14 2018-09-14 １９−ノルｃ３，３−二置換ｃ２１−ｎ−ピラゾリルステロイドおよびその使用方法
JP2023008782A Pending JP2023038310A (ja) 2017-09-14 2023-01-24 １９－ノルｃ３，３－二置換ｃ２１－ｎ－ピラゾリルステロイドおよびその使用方法
JP2024091642A Pending JP2024107137A (ja) 2017-09-14 2024-06-05 １９－ノルｃ３，３－二置換ｃ２１－ｎ－ピラゾリルステロイドおよびその使用方法

Family Applications After (2)

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JP2023008782A Pending JP2023038310A (ja) 2017-09-14 2023-01-24 １９－ノルｃ３，３－二置換ｃ２１－ｎ－ピラゾリルステロイドおよびその使用方法
JP2024091642A Pending JP2024107137A (ja) 2017-09-14 2024-06-05 １９－ノルｃ３，３－二置換ｃ２１－ｎ－ピラゾリルステロイドおよびその使用方法

Country Status (9)

Country Link
US (3) US20220110949A1 (https=)
EP (3) EP4218767A1 (https=)
JP (3) JP2020534270A (https=)
AU (2) AU2018334214A1 (https=)
CA (1) CA3075872A1 (https=)
IL (2) IL303083A (https=)
MX (3) MX2020002889A (https=)
TW (2) TW202339764A (https=)
WO (1) WO2019055764A1 (https=)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2806877B2 (en) 2012-01-23 2025-01-29 Sage Therapeutics, Inc. Neuroactive steroid formulations comprising a complex of allopregnanolone and sulfobutyl ether beta-cyclodextrin
CA2882708A1 (en) 2012-08-21 2014-02-27 Sage Therapeutics, Inc. Methods of treating epilepsy or status epilepticus
KR102396328B1 (ko) 2013-04-17 2022-05-10 세이지 테라퓨틱스, 인크. 19-노르 c3,3-이치환된 c21-n-피라졸릴 스테로이드 및 그의 사용 방법
US10246482B2 (en) 2014-06-18 2019-04-02 Sage Therapeutics, Inc. Neuroactive steroids, compositions, and uses thereof
JOP20200195A1 (ar) 2014-09-08 2017-06-16 Sage Therapeutics Inc سترويدات وتركيبات نشطة عصبياً، واستخداماتها
WO2016082789A1 (en) 2014-11-27 2016-06-02 Sage Therapeutics, Inc. Compositions and methods for treating cns disorders
EP3504189A1 (en) 2016-08-23 2019-07-03 Sage Therapeutics, Inc. A crystalline 19-nor c3, 3-disubstituted c21-n-pyrazolyl steroid
MA51046A (fr) 2017-12-08 2021-03-17 Sage Therapeutics Inc Dérivés de 21-[4-cyano-pyrazol-1-yl]-19-nor-pregan-3. alpha-ol-20-one deutérés pour le traitement de troubles du snc
US10857163B1 (en) 2019-09-30 2020-12-08 Athenen Therapeutics, Inc. Compositions that preferentially potentiate subtypes of GABAA receptors and methods of use thereof
KR20220112803A (ko) * 2019-12-05 2022-08-11 세이지 테라퓨틱스, 인크. 19-nor c3,3-이치환된 c21-n-피라졸릴 스테로이드 및 그의 사용 방법

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016517851A (ja) * 2013-04-17 2016-06-20 セージ セラピューティクス， インコーポレイテッド １９−ノルｃ３，３−ジ置換ｃ２１−ｎ−ピラゾリルステロイドおよびその使用方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ME03809B (me) * 2014-10-16 2021-04-20 Sage Therapeutics Inc KOMPOZICIJE I POSTUPCI ZA LEČENJE POREMEĆAJA CNS-a
EP3504189A1 (en) * 2016-08-23 2019-07-03 Sage Therapeutics, Inc. A crystalline 19-nor c3, 3-disubstituted c21-n-pyrazolyl steroid
WO2019051264A1 (en) * 2017-09-07 2019-03-14 Sage Therapeutics, Inc. NEUROACTIVE STEROIDS AND METHODS OF USE

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016517851A (ja) * 2013-04-17 2016-06-20 セージ セラピューティクス， インコーポレイテッド １９−ノルｃ３，３−ジ置換ｃ２１−ｎ−ピラゾリルステロイドおよびその使用方法

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
EPILEPSIA, vol. 58, no. 2, JPN6022030870, February 2017 (2017-02-01), pages 181 - 221, ISSN: 0005013839 *
INT. J. PHARM. LIFE SCI., vol. Vol.4 Iss.2, JPN6022030873, 2013, pages 2396 - 2401, ISSN: 0005013841 *
J. MED. CHEM., vol. 60, JPN6022030867, July 2017 (2017-07-01), pages 7810 - 7819, ISSN: 0005013838 *
TRENDS PHARMACOL. SCI., vol. 20, no. 3, JPN6022030871, 1999, pages 107 - 112, ISSN: 0005013840 *

Also Published As

Publication number Publication date
MX2023010063A (es) 2023-09-06
JP2023038310A (ja) 2023-03-16
WO2019055764A1 (en) 2019-03-21
TW202339764A (zh) 2023-10-16
IL303083A (en) 2023-07-01
US20230201224A1 (en) 2023-06-29
AU2024205601A1 (en) 2024-08-29
CA3075872A1 (en) 2019-03-21
EP4696301A3 (en) 2026-04-29
AU2018334214A1 (en) 2020-03-26
EP4218767A1 (en) 2023-08-02
US20250387414A1 (en) 2025-12-25
EP3681510A1 (en) 2020-07-22
MX2020002889A (es) 2020-10-01
MX2023010064A (es) 2023-09-06
JP2024107137A (ja) 2024-08-08
US20220110949A1 (en) 2022-04-14
TW201919642A (zh) 2019-06-01
IL273126A (en) 2020-04-30
EP4696301A2 (en) 2026-02-18

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