IL303083A - 19-NOR C3,3-C21-N-pyrazolyl steroid dimer and methods of using it - Google Patents
19-NOR C3,3-C21-N-pyrazolyl steroid dimer and methods of using itInfo
- Publication number
- IL303083A IL303083A IL303083A IL30308323A IL303083A IL 303083 A IL303083 A IL 303083A IL 303083 A IL303083 A IL 303083A IL 30308323 A IL30308323 A IL 30308323A IL 303083 A IL303083 A IL 303083A
- Authority
- IL
- Israel
- Prior art keywords
- compound
- sleep
- subject
- administered
- effective amount
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4816—Wall or shell material
- A61K9/4825—Proteins, e.g. gelatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Anesthesiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762558703P | 2017-09-14 | 2017-09-14 | |
| US201862624678P | 2018-01-31 | 2018-01-31 | |
| US201862624680P | 2018-01-31 | 2018-01-31 | |
| US201862653189P | 2018-04-05 | 2018-04-05 | |
| PCT/US2018/051048 WO2019055764A1 (en) | 2017-09-14 | 2018-09-14 | C21-N-PYRAZOLYL C3,3-DISUBSTITUTED STEROID 19 NOR, AND METHODS OF USING THE SAME |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL303083A true IL303083A (en) | 2023-07-01 |
Family
ID=65723895
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL303083A IL303083A (en) | 2017-09-14 | 2018-09-14 | 19-NOR C3,3-C21-N-pyrazolyl steroid dimer and methods of using it |
| IL273126A IL273126A (en) | 2017-09-14 | 2020-03-08 | 19-NOR C3,3-dimethyl C21-N-pyrazolyl steroid and methods of using it |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL273126A IL273126A (en) | 2017-09-14 | 2020-03-08 | 19-NOR C3,3-dimethyl C21-N-pyrazolyl steroid and methods of using it |
Country Status (9)
| Country | Link |
|---|---|
| US (3) | US20220110949A1 (https=) |
| EP (3) | EP4218767A1 (https=) |
| JP (3) | JP2020534270A (https=) |
| AU (2) | AU2018334214A1 (https=) |
| CA (1) | CA3075872A1 (https=) |
| IL (2) | IL303083A (https=) |
| MX (3) | MX2020002889A (https=) |
| TW (2) | TW202339764A (https=) |
| WO (1) | WO2019055764A1 (https=) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2806877B2 (en) | 2012-01-23 | 2025-01-29 | Sage Therapeutics, Inc. | Neuroactive steroid formulations comprising a complex of allopregnanolone and sulfobutyl ether beta-cyclodextrin |
| CA2882708A1 (en) | 2012-08-21 | 2014-02-27 | Sage Therapeutics, Inc. | Methods of treating epilepsy or status epilepticus |
| KR102396328B1 (ko) | 2013-04-17 | 2022-05-10 | 세이지 테라퓨틱스, 인크. | 19-노르 c3,3-이치환된 c21-n-피라졸릴 스테로이드 및 그의 사용 방법 |
| US10246482B2 (en) | 2014-06-18 | 2019-04-02 | Sage Therapeutics, Inc. | Neuroactive steroids, compositions, and uses thereof |
| JOP20200195A1 (ar) | 2014-09-08 | 2017-06-16 | Sage Therapeutics Inc | سترويدات وتركيبات نشطة عصبياً، واستخداماتها |
| WO2016082789A1 (en) | 2014-11-27 | 2016-06-02 | Sage Therapeutics, Inc. | Compositions and methods for treating cns disorders |
| EP3504189A1 (en) | 2016-08-23 | 2019-07-03 | Sage Therapeutics, Inc. | A crystalline 19-nor c3, 3-disubstituted c21-n-pyrazolyl steroid |
| MA51046A (fr) | 2017-12-08 | 2021-03-17 | Sage Therapeutics Inc | Dérivés de 21-[4-cyano-pyrazol-1-yl]-19-nor-pregan-3. alpha-ol-20-one deutérés pour le traitement de troubles du snc |
| US10857163B1 (en) | 2019-09-30 | 2020-12-08 | Athenen Therapeutics, Inc. | Compositions that preferentially potentiate subtypes of GABAA receptors and methods of use thereof |
| KR20220112803A (ko) * | 2019-12-05 | 2022-08-11 | 세이지 테라퓨틱스, 인크. | 19-nor c3,3-이치환된 c21-n-피라졸릴 스테로이드 및 그의 사용 방법 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102396328B1 (ko) * | 2013-04-17 | 2022-05-10 | 세이지 테라퓨틱스, 인크. | 19-노르 c3,3-이치환된 c21-n-피라졸릴 스테로이드 및 그의 사용 방법 |
| ME03809B (me) * | 2014-10-16 | 2021-04-20 | Sage Therapeutics Inc | KOMPOZICIJE I POSTUPCI ZA LEČENJE POREMEĆAJA CNS-a |
| EP3504189A1 (en) * | 2016-08-23 | 2019-07-03 | Sage Therapeutics, Inc. | A crystalline 19-nor c3, 3-disubstituted c21-n-pyrazolyl steroid |
| WO2019051264A1 (en) * | 2017-09-07 | 2019-03-14 | Sage Therapeutics, Inc. | NEUROACTIVE STEROIDS AND METHODS OF USE |
-
2018
- 2018-09-14 CA CA3075872A patent/CA3075872A1/en active Pending
- 2018-09-14 AU AU2018334214A patent/AU2018334214A1/en not_active Abandoned
- 2018-09-14 EP EP23150618.9A patent/EP4218767A1/en not_active Withdrawn
- 2018-09-14 JP JP2020514950A patent/JP2020534270A/ja active Pending
- 2018-09-14 IL IL303083A patent/IL303083A/en unknown
- 2018-09-14 TW TW111150395A patent/TW202339764A/zh unknown
- 2018-09-14 EP EP18786464.0A patent/EP3681510A1/en not_active Withdrawn
- 2018-09-14 WO PCT/US2018/051048 patent/WO2019055764A1/en not_active Ceased
- 2018-09-14 EP EP25207758.1A patent/EP4696301A3/en active Pending
- 2018-09-14 MX MX2020002889A patent/MX2020002889A/es unknown
- 2018-09-14 US US16/647,203 patent/US20220110949A1/en not_active Abandoned
- 2018-09-14 TW TW107132510A patent/TW201919642A/zh unknown
-
2020
- 2020-03-08 IL IL273126A patent/IL273126A/en unknown
- 2020-03-13 MX MX2023010063A patent/MX2023010063A/es unknown
- 2020-03-13 MX MX2023010064A patent/MX2023010064A/es unknown
-
2023
- 2023-01-24 JP JP2023008782A patent/JP2023038310A/ja active Pending
- 2023-03-01 US US18/176,571 patent/US20230201224A1/en not_active Abandoned
-
2024
- 2024-06-05 JP JP2024091642A patent/JP2024107137A/ja active Pending
- 2024-08-07 AU AU2024205601A patent/AU2024205601A1/en active Pending
-
2025
- 2025-05-08 US US19/202,525 patent/US20250387414A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| MX2023010063A (es) | 2023-09-06 |
| JP2023038310A (ja) | 2023-03-16 |
| WO2019055764A1 (en) | 2019-03-21 |
| TW202339764A (zh) | 2023-10-16 |
| US20230201224A1 (en) | 2023-06-29 |
| AU2024205601A1 (en) | 2024-08-29 |
| CA3075872A1 (en) | 2019-03-21 |
| EP4696301A3 (en) | 2026-04-29 |
| AU2018334214A1 (en) | 2020-03-26 |
| EP4218767A1 (en) | 2023-08-02 |
| US20250387414A1 (en) | 2025-12-25 |
| EP3681510A1 (en) | 2020-07-22 |
| MX2020002889A (es) | 2020-10-01 |
| MX2023010064A (es) | 2023-09-06 |
| JP2024107137A (ja) | 2024-08-08 |
| JP2020534270A (ja) | 2020-11-26 |
| US20220110949A1 (en) | 2022-04-14 |
| TW201919642A (zh) | 2019-06-01 |
| IL273126A (en) | 2020-04-30 |
| EP4696301A2 (en) | 2026-02-18 |
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