JP2020534261A5 - - Google Patents
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- JP2020534261A5 JP2020534261A5 JP2020514212A JP2020514212A JP2020534261A5 JP 2020534261 A5 JP2020534261 A5 JP 2020534261A5 JP 2020514212 A JP2020514212 A JP 2020514212A JP 2020514212 A JP2020514212 A JP 2020514212A JP 2020534261 A5 JP2020534261 A5 JP 2020534261A5
- Authority
- JP
- Japan
- Prior art keywords
- protein
- seq
- anchor
- optionally
- tissue
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 102000004169 proteins and genes Human genes 0.000 claims 50
- 108090000623 proteins and genes Proteins 0.000 claims 50
- 239000000203 mixture Substances 0.000 claims 28
- 238000000034 method Methods 0.000 claims 21
- 150000003904 phospholipids Chemical class 0.000 claims 18
- 210000004027 cell Anatomy 0.000 claims 16
- 239000004094 surface-active agent Substances 0.000 claims 15
- 108090000190 Thrombin Proteins 0.000 claims 8
- 229960004072 thrombin Drugs 0.000 claims 8
- 108010094028 Prothrombin Proteins 0.000 claims 7
- 102100027378 Prothrombin Human genes 0.000 claims 7
- 230000035876 healing Effects 0.000 claims 7
- 229920000642 polymer Polymers 0.000 claims 7
- 229940039716 prothrombin Drugs 0.000 claims 7
- 108090000790 Enzymes Proteins 0.000 claims 5
- 102000004190 Enzymes Human genes 0.000 claims 5
- 229940088598 enzyme Drugs 0.000 claims 5
- 230000012010 growth Effects 0.000 claims 4
- 238000000338 in vitro Methods 0.000 claims 4
- 239000012528 membrane Substances 0.000 claims 4
- 108020004511 Recombinant DNA Proteins 0.000 claims 3
- 125000003275 alpha amino acid group Chemical group 0.000 claims 3
- 230000021615 conjugation Effects 0.000 claims 3
- 229920001184 polypeptide Polymers 0.000 claims 3
- 239000002243 precursor Substances 0.000 claims 3
- 102000004196 processed proteins & peptides Human genes 0.000 claims 3
- 108090000765 processed proteins & peptides Proteins 0.000 claims 3
- 230000008467 tissue growth Effects 0.000 claims 3
- 231100000167 toxic agent Toxicity 0.000 claims 3
- 239000003440 toxic substance Substances 0.000 claims 3
- 108010049003 Fibrinogen Proteins 0.000 claims 2
- 102000008946 Fibrinogen Human genes 0.000 claims 2
- 230000000593 degrading effect Effects 0.000 claims 2
- 229940012952 fibrinogen Drugs 0.000 claims 2
- 108020001507 fusion proteins Proteins 0.000 claims 2
- 102000037865 fusion proteins Human genes 0.000 claims 2
- 210000002901 mesenchymal stem cell Anatomy 0.000 claims 2
- 239000000693 micelle Substances 0.000 claims 2
- 230000003472 neutralizing effect Effects 0.000 claims 2
- 150000002903 organophosphorus compounds Chemical class 0.000 claims 2
- FPQQSJJWHUJYPU-UHFFFAOYSA-N 3-(dimethylamino)propyliminomethylidene-ethylazanium;chloride Chemical compound Cl.CCN=C=NCCCN(C)C FPQQSJJWHUJYPU-UHFFFAOYSA-N 0.000 claims 1
- 208000031229 Cardiomyopathies Diseases 0.000 claims 1
- 102000004856 Lectins Human genes 0.000 claims 1
- 108090001090 Lectins Proteins 0.000 claims 1
- 241001465754 Metazoa Species 0.000 claims 1
- 208000009525 Myocarditis Diseases 0.000 claims 1
- 125000000129 anionic group Chemical group 0.000 claims 1
- 150000001718 carbodiimides Chemical class 0.000 claims 1
- 210000004413 cardiac myocyte Anatomy 0.000 claims 1
- 238000004140 cleaning Methods 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000012202 endocytosis Effects 0.000 claims 1
- 102000006495 integrins Human genes 0.000 claims 1
- 108010044426 integrins Proteins 0.000 claims 1
- 238000002372 labelling Methods 0.000 claims 1
- 239000002523 lectin Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- PSGAAPLEWMOORI-PEINSRQWSA-N medroxyprogesterone acetate Chemical compound C([C@@]12C)CC(=O)C=C1[C@@H](C)C[C@@H]1[C@@H]2CC[C@]2(C)[C@@](OC(C)=O)(C(C)=O)CC[C@H]21 PSGAAPLEWMOORI-PEINSRQWSA-N 0.000 claims 1
- 208000010125 myocardial infarction Diseases 0.000 claims 1
- UQUPIHHYKUEXQD-UHFFFAOYSA-N n,n′-dimethyl-1,3-propanediamine Chemical compound CNCCCNC UQUPIHHYKUEXQD-UHFFFAOYSA-N 0.000 claims 1
- 239000002574 poison Substances 0.000 claims 1
- 231100000614 poison Toxicity 0.000 claims 1
- 230000001737 promoting effect Effects 0.000 claims 1
- 238000001542 size-exclusion chromatography Methods 0.000 claims 1
- 238000003756 stirring Methods 0.000 claims 1
- 230000008685 targeting Effects 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
- 239000003981 vehicle Substances 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1714485.8A GB201714485D0 (en) | 2017-09-08 | 2017-09-08 | Protein delivery to membranes |
| GB1714485.8 | 2017-09-08 | ||
| GB1714566.5 | 2017-09-11 | ||
| GBGB1714566.5A GB201714566D0 (en) | 2017-09-11 | 2017-09-11 | Protein delivery to membranes |
| PCT/GB2018/052534 WO2019048871A1 (en) | 2017-09-08 | 2018-09-07 | PROTEIN ADMINISTRATION TO MEMBRANES |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2020534261A JP2020534261A (ja) | 2020-11-26 |
| JP2020534261A5 true JP2020534261A5 (enExample) | 2021-09-09 |
Family
ID=63840877
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020514212A Pending JP2020534261A (ja) | 2017-09-08 | 2018-09-07 | 膜へのタンパク質送達 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US11723985B2 (enExample) |
| EP (1) | EP3679055A1 (enExample) |
| JP (1) | JP2020534261A (enExample) |
| CN (1) | CN111094322A (enExample) |
| CA (1) | CA3074593A1 (enExample) |
| WO (1) | WO2019048871A1 (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW202241929A (zh) * | 2021-01-12 | 2022-11-01 | 美商詹森藥物公司 | ＦｉｍＨ突變體、其組成物及其用途 |
| US20230357514A1 (en) * | 2022-05-03 | 2023-11-09 | Ues, Inc. | Complexated biomolecules for use in contaminated soil or groundwater cleanup |
| US20230374228A1 (en) * | 2022-05-23 | 2023-11-23 | Indian Institute Of Technology Bombay | Solvent-free liquid from regenerated silk fibroin: a writeable and shapeable material |
| CN119735657A (zh) * | 2024-12-18 | 2025-04-01 | 江南大学 | 一种具有优良吸附水体微塑料能力的CsgA蛋白重组体及其应用 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1019071A4 (en) * | 1997-05-15 | 2003-07-30 | Cytogen Corp | Arbitrary peptides which transport receptors of the gastro-intestinal tract bind and process with it |
| JP3252164B2 (ja) * | 1997-07-04 | 2002-01-28 | 独立行政法人産業技術総合研究所 | 光合成膜蛋白質組み込みベシクル膜の製造方法 |
| WO2002038609A2 (en) * | 2000-11-10 | 2002-05-16 | Proteopharma Aps | Apolipoprotein conjugates |
| AUPR502301A0 (en) * | 2001-05-15 | 2001-06-07 | Commonwealth Scientific And Industrial Research Organisation | Phosphotriesterase from Agrobacterium radiobacter P230 |
| US8969543B2 (en) | 2003-04-03 | 2015-03-03 | Bioneer Corporation | SiRNA-hydrophilic polymer conjugates for intracellular delivery of siRNA and method thereof |
| US7740861B2 (en) * | 2004-06-16 | 2010-06-22 | University Of Massachusetts | Drug delivery product and methods |
| DE102005029704A1 (de) * | 2005-06-24 | 2007-01-11 | Basf Ag | Verwendung von Hydrophobin-Polypeptiden sowie Konjugaten aus Hydrophobin-Polypeptiden mit Wirk-oder Effektstoffen und ihre Herstellung sowie deren Einsatz in der Kosmetik |
| DE102005032055A1 (de) * | 2005-07-08 | 2007-01-25 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Ein rekombinantes und modifiziertes eukaryontisches Membranprotein als Anker extrazellulärer Funktionalitäten |
| EP3045532A1 (en) | 2006-06-02 | 2016-07-20 | President and Fellows of Harvard College | Protein surface remodeling |
| US9259398B1 (en) * | 2007-11-26 | 2016-02-16 | Abbott Cardiovascular Systems Inc. | Bioactive agent-loaded targeting micelles |
| CA2725601A1 (en) | 2008-04-28 | 2009-11-05 | President And Fellows Of Harvard College | Supercharged proteins for cell penetration |
| JP2012525146A (ja) * | 2009-04-28 | 2012-10-22 | プレジデント アンド フェロウズ オブ ハーバード カレッジ | 細胞透過のための過剰に荷電されたタンパク質 |
| WO2013142229A1 (en) * | 2012-03-19 | 2013-09-26 | President And Fellows Of Harvard College | Designing novel peptides for inducing fibronectin matrix assembly |
| US9815871B2 (en) | 2013-04-23 | 2017-11-14 | President And Fellows Of Harvard College | Genetic reprogramming of bacterial biofilms |
| WO2015017424A1 (en) * | 2013-07-29 | 2015-02-05 | Vivoscript, Inc. | Transducible materials for cell reprogramming |
| CN103525782A (zh) * | 2013-10-11 | 2014-01-22 | 上海市农业科学院 | 一种突变的有机磷农药降解酶基因及其应用 |
| WO2016069910A1 (en) | 2014-10-29 | 2016-05-06 | Massachusetts Eye And Ear Infirmary | Methods for efficient delivery of therapeutic molecules in vitro and in vivo |
| WO2017187114A1 (en) | 2016-04-29 | 2017-11-02 | The University Of Bristol | Improvements in 3d printing |
-
2018
- 2018-09-07 JP JP2020514212A patent/JP2020534261A/ja active Pending
- 2018-09-07 EP EP18786010.1A patent/EP3679055A1/en not_active Withdrawn
- 2018-09-07 CN CN201880058495.XA patent/CN111094322A/zh active Pending
- 2018-09-07 CA CA3074593A patent/CA3074593A1/en active Pending
- 2018-09-07 US US16/644,354 patent/US11723985B2/en active Active
- 2018-09-07 WO PCT/GB2018/052534 patent/WO2019048871A1/en not_active Ceased
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