JP2020530759A5 - - Google Patents
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- JP2020530759A5 JP2020530759A5 JP2019571705A JP2019571705A JP2020530759A5 JP 2020530759 A5 JP2020530759 A5 JP 2020530759A5 JP 2019571705 A JP2019571705 A JP 2019571705A JP 2019571705 A JP2019571705 A JP 2019571705A JP 2020530759 A5 JP2020530759 A5 JP 2020530759A5
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- Prior art keywords
- peptide
- cancer
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- variant
- cell
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 108090000765 processed proteins & peptides Proteins 0.000 claims 47
- 206010028980 Neoplasm Diseases 0.000 claims 19
- 239000012634 fragment Substances 0.000 claims 18
- 210000001744 T-lymphocyte Anatomy 0.000 claims 14
- 238000000034 method Methods 0.000 claims 13
- 108700018351 Major Histocompatibility Complex Proteins 0.000 claims 12
- 230000020382 suppression by virus of host antigen processing and presentation of peptide antigen via MHC class I Effects 0.000 claims 12
- 102000016266 T-Cell Antigen Receptors Human genes 0.000 claims 11
- 108091008874 T cell receptors Proteins 0.000 claims 10
- 210000004027 cell Anatomy 0.000 claims 10
- 210000001519 tissue Anatomy 0.000 claims 10
- 239000003446 ligand Substances 0.000 claims 9
- 108020004707 nucleic acids Proteins 0.000 claims 8
- 102000039446 nucleic acids Human genes 0.000 claims 8
- 150000007523 nucleic acids Chemical class 0.000 claims 8
- 125000003275 alpha amino acid group Chemical group 0.000 claims 7
- 108090000623 proteins and genes Proteins 0.000 claims 7
- 239000013604 expression vector Substances 0.000 claims 6
- 108091023037 Aptamer Proteins 0.000 claims 5
- 239000000427 antigen Substances 0.000 claims 5
- 108091007433 antigens Proteins 0.000 claims 5
- 102000036639 antigens Human genes 0.000 claims 5
- 201000011510 cancer Diseases 0.000 claims 5
- 230000005847 immunogenicity Effects 0.000 claims 5
- 238000000338 in vitro Methods 0.000 claims 5
- 238000010195 expression analysis Methods 0.000 claims 4
- 230000014509 gene expression Effects 0.000 claims 4
- 102000004196 processed proteins & peptides Human genes 0.000 claims 4
- 210000000612 antigen-presenting cell Anatomy 0.000 claims 3
- 238000003556 assay Methods 0.000 claims 3
- 238000002659 cell therapy Methods 0.000 claims 3
- 230000035772 mutation Effects 0.000 claims 3
- 229920001184 polypeptide Polymers 0.000 claims 3
- 102000004169 proteins and genes Human genes 0.000 claims 3
- 238000012163 sequencing technique Methods 0.000 claims 3
- 108091054437 MHC class I family Proteins 0.000 claims 2
- 102000043129 MHC class I family Human genes 0.000 claims 2
- 230000005867 T cell response Effects 0.000 claims 2
- 239000004480 active ingredient Substances 0.000 claims 2
- 150000001413 amino acids Chemical class 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- 238000001514 detection method Methods 0.000 claims 2
- 239000003085 diluting agent Substances 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 238000001727 in vivo Methods 0.000 claims 2
- 230000006698 induction Effects 0.000 claims 2
- 230000003211 malignant effect Effects 0.000 claims 2
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- 230000002018 overexpression Effects 0.000 claims 2
- 229920002477 rna polymer Polymers 0.000 claims 2
- 238000010186 staining Methods 0.000 claims 2
- 208000031261 Acute myeloid leukaemia Diseases 0.000 claims 1
- 208000010839 B-cell chronic lymphocytic leukemia Diseases 0.000 claims 1
- 206010004593 Bile duct cancer Diseases 0.000 claims 1
- 208000003174 Brain Neoplasms Diseases 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 201000009030 Carcinoma Diseases 0.000 claims 1
- 102000004127 Cytokines Human genes 0.000 claims 1
- 108090000695 Cytokines Proteins 0.000 claims 1
- 238000011510 Elispot assay Methods 0.000 claims 1
- 208000000461 Esophageal Neoplasms Diseases 0.000 claims 1
- 102000006354 HLA-DR Antigens Human genes 0.000 claims 1
- 108010058597 HLA-DR Antigens Proteins 0.000 claims 1
- 108010027412 Histocompatibility Antigens Class II Proteins 0.000 claims 1
- 102000018713 Histocompatibility Antigens Class II Human genes 0.000 claims 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
- 208000031422 Lymphocytic Chronic B-Cell Leukemia Diseases 0.000 claims 1
- 208000033776 Myeloid Acute Leukemia Diseases 0.000 claims 1
- 125000001429 N-terminal alpha-amino-acid group Chemical group 0.000 claims 1
- 208000015914 Non-Hodgkin lymphomas Diseases 0.000 claims 1
- 206010030155 Oesophageal carcinoma Diseases 0.000 claims 1
- 206010033128 Ovarian cancer Diseases 0.000 claims 1
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
- 208000015634 Rectal Neoplasms Diseases 0.000 claims 1
- 208000006265 Renal cell carcinoma Diseases 0.000 claims 1
- 206010041067 Small cell lung cancer Diseases 0.000 claims 1
- 208000005718 Stomach Neoplasms Diseases 0.000 claims 1
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims 1
- 208000002495 Uterine Neoplasms Diseases 0.000 claims 1
- 230000003213 activating effect Effects 0.000 claims 1
- 210000000941 bile Anatomy 0.000 claims 1
- 208000026900 bile duct neoplasm Diseases 0.000 claims 1
- 229940022399 cancer vaccine Drugs 0.000 claims 1
- 208000006990 cholangiocarcinoma Diseases 0.000 claims 1
- 208000032852 chronic lymphocytic leukemia Diseases 0.000 claims 1
- 230000000112 colonic effect Effects 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 210000004443 dendritic cell Anatomy 0.000 claims 1
- 238000003745 diagnosis Methods 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 239000012636 effector Substances 0.000 claims 1
- 238000003114 enzyme-linked immunosorbent spot assay Methods 0.000 claims 1
- 201000004101 esophageal cancer Diseases 0.000 claims 1
- 238000009472 formulation Methods 0.000 claims 1
- 238000004108 freeze drying Methods 0.000 claims 1
- 108020001507 fusion proteins Proteins 0.000 claims 1
- 102000037865 fusion proteins Human genes 0.000 claims 1
- 206010017758 gastric cancer Diseases 0.000 claims 1
- 239000001963 growth medium Substances 0.000 claims 1
- 206010073071 hepatocellular carcinoma Diseases 0.000 claims 1
- 231100000844 hepatocellular carcinoma Toxicity 0.000 claims 1
- 230000003308 immunostimulating effect Effects 0.000 claims 1
- 230000003834 intracellular effect Effects 0.000 claims 1
- 108010028930 invariant chain Proteins 0.000 claims 1
- 201000005202 lung cancer Diseases 0.000 claims 1
- 208000020816 lung neoplasm Diseases 0.000 claims 1
- 239000012931 lyophilized formulation Substances 0.000 claims 1
- 238000004949 mass spectrometry Methods 0.000 claims 1
- 201000001441 melanoma Diseases 0.000 claims 1
- 210000000822 natural killer cell Anatomy 0.000 claims 1
- 208000002154 non-small cell lung carcinoma Diseases 0.000 claims 1
- 210000000496 pancreas Anatomy 0.000 claims 1
- 229940038309 personalized vaccine Drugs 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 108020003175 receptors Proteins 0.000 claims 1
- 206010038038 rectal cancer Diseases 0.000 claims 1
- 201000001275 rectum cancer Diseases 0.000 claims 1
- 208000015347 renal cell adenocarcinoma Diseases 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 239000003381 stabilizer Substances 0.000 claims 1
- 201000011549 stomach cancer Diseases 0.000 claims 1
- 238000003860 storage Methods 0.000 claims 1
- 239000003053 toxin Substances 0.000 claims 1
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- 229960005486 vaccine Drugs 0.000 claims 1
- 238000012070 whole genome sequencing analysis Methods 0.000 claims 1
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023152293A JP2024001045A (ja) | 2017-07-07 | 2023-09-20 | Ｎｓｃｌｃ、ｓｃｌｃ、およびその他のがんをはじめとする肺がんに対する免疫療法で使用するための新規ペプチドおよびペプチド併用 |
| JP2024215092A JP2025038026A (ja) | 2017-07-07 | 2024-12-10 | Ｎｓｃｌｃ、ｓｃｌｃ、およびその他のがんをはじめとする肺がんに対する免疫療法で使用するための新規ペプチドおよびペプチド併用 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762529758P | 2017-07-07 | 2017-07-07 | |
| DE102017115301 | 2017-07-07 | ||
| DE102017115301.2 | 2017-07-07 | ||
| US62/529,758 | 2017-07-07 | ||
| PCT/EP2018/067979 WO2019007974A1 (en) | 2017-07-07 | 2018-07-03 | NOVEL PEPTIDES AND COMBINATION OF PEPTIDES FOR USE IN IMMUNOTHERAPY OF LUNG CANCER, INCLUDING NSCLC, CPPC AND OTHER CANCERS |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023152293A Division JP2024001045A (ja) | 2017-07-07 | 2023-09-20 | Ｎｓｃｌｃ、ｓｃｌｃ、およびその他のがんをはじめとする肺がんに対する免疫療法で使用するための新規ペプチドおよびペプチド併用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2020530759A JP2020530759A (ja) | 2020-10-29 |
| JP2020530759A5 true JP2020530759A5 (https=) | 2021-08-19 |
Family
ID=62904428
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019571705A Pending JP2020530759A (ja) | 2017-07-07 | 2018-07-03 | Ｎｓｃｌｃ、ｓｃｌｃ、およびその他のがんをはじめとする肺がんに対する免疫療法で使用するための新規ペプチドおよびペプチド併用 |
| JP2023152293A Pending JP2024001045A (ja) | 2017-07-07 | 2023-09-20 | Ｎｓｃｌｃ、ｓｃｌｃ、およびその他のがんをはじめとする肺がんに対する免疫療法で使用するための新規ペプチドおよびペプチド併用 |
| JP2024215092A Pending JP2025038026A (ja) | 2017-07-07 | 2024-12-10 | Ｎｓｃｌｃ、ｓｃｌｃ、およびその他のがんをはじめとする肺がんに対する免疫療法で使用するための新規ペプチドおよびペプチド併用 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023152293A Pending JP2024001045A (ja) | 2017-07-07 | 2023-09-20 | Ｎｓｃｌｃ、ｓｃｌｃ、およびその他のがんをはじめとする肺がんに対する免疫療法で使用するための新規ペプチドおよびペプチド併用 |
| JP2024215092A Pending JP2025038026A (ja) | 2017-07-07 | 2024-12-10 | Ｎｓｃｌｃ、ｓｃｌｃ、およびその他のがんをはじめとする肺がんに対する免疫療法で使用するための新規ペプチドおよびペプチド併用 |
Country Status (18)
| Country | Link |
|---|---|
| US (47) | US10472402B2 (https=) |
| EP (2) | EP3648790A1 (https=) |
| JP (3) | JP2020530759A (https=) |
| KR (2) | KR20200026898A (https=) |
| CN (2) | CN110785183B (https=) |
| AU (3) | AU2018297578C1 (https=) |
| BR (1) | BR112019028070A2 (https=) |
| CA (1) | CA3068852A1 (https=) |
| CL (4) | CL2020000020A1 (https=) |
| CO (1) | CO2020001141A2 (https=) |
| CR (4) | CR20210167A (https=) |
| IL (2) | IL271895A (https=) |
| MX (2) | MX2019015879A (https=) |
| MY (1) | MY198706A (https=) |
| PE (1) | PE20200693A1 (https=) |
| PH (1) | PH12020500051A1 (https=) |
| SG (1) | SG11201913302SA (https=) |
| TW (1) | TW201906859A (https=) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2019015879A (es) | 2017-07-07 | 2020-02-07 | Immatics Biotechnologies Gmbh | Nuevos peptidos y nuevas combinacones de peptidos para el uso en la inmunoterapia contra el cancer de pulmon, incluyendo el nsclc, el sclc y otros canceres. |
| US10800823B2 (en) | 2017-07-07 | 2020-10-13 | Immatics Biotechnologies Gmbh | Peptides and combination of peptides for use in immunotherapy against lung cancer, including NSCLC, SCLC and other cancers |
| CN111732629B (zh) * | 2020-06-19 | 2022-05-03 | 完美（广东）日用品有限公司 | 一种寡肽、减肥组合物及制备方法和应用 |
| JP2024501482A (ja) * | 2020-12-14 | 2024-01-12 | ビオンテック ユーエス インコーポレイテッド | がん免疫療法のための組織特異的抗原 |
| CN114019165B (zh) * | 2022-01-05 | 2022-04-01 | 首都医科大学附属北京妇产医院 | 多肽芯片或试剂盒及其在诊断非小细胞肺癌中的应用 |
| CN115785212B (zh) * | 2022-06-10 | 2024-08-30 | 河北博海生物工程开发有限公司 | 肺癌特异性分子靶标03及其用途 |
| CN116879433A (zh) * | 2023-07-05 | 2023-10-13 | 国纳之星(上海)纳米科技发展有限公司 | 肺癌患患者特异性生物标志组合物及其用途 |
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| WO2017150681A1 (ja) * | 2016-03-03 | 2017-09-08 | 東亞合成株式会社 | シグナルペプチドを指標にした筋萎縮性側索硬化症の診断方法 |
| AU2017254477A1 (en) * | 2016-04-18 | 2018-11-01 | Jennifer G. ABELIN | Improved HLA epitope prediction |
| SG11201909058WA (en) * | 2017-04-10 | 2019-10-30 | Immatics Biotechnologies Gmbh | Peptides and combination of peptides for use in immunotherapy against leukemias and other cancers |
| BR112019020959A2 (pt) * | 2017-04-10 | 2020-05-05 | Immatics Biotechnologies Gmbh | peptídeos e combinações dos mesmos para uso na imunoterapia contra câncer |
| SG11201911430PA (en) * | 2017-07-04 | 2020-01-30 | Curevac Ag | Novel nucleic acid molecules |
| MX2019015879A (es) | 2017-07-07 | 2020-02-07 | Immatics Biotechnologies Gmbh | Nuevos peptidos y nuevas combinacones de peptidos para el uso en la inmunoterapia contra el cancer de pulmon, incluyendo el nsclc, el sclc y otros canceres. |
| US10800823B2 (en) | 2017-07-07 | 2020-10-13 | Immatics Biotechnologies Gmbh | Peptides and combination of peptides for use in immunotherapy against lung cancer, including NSCLC, SCLC and other cancers |
| JP2021526365A (ja) * | 2018-05-18 | 2021-10-07 | チルドレンズ ナショナル メディカル センターＣｈｉｌｄｒｅｎ’Ｓ Ｎａｔｉｏｎａｌ Ｍｅｄｉｃａｌ Ｃｅｎｔｅｒ | 改善された標的化ｔ細胞療法 |
| TW202028224A (zh) * | 2018-09-17 | 2020-08-01 | 德商英麥提克生物技術股份有限公司 | B*44限制肽在抗癌免疫治療的用途和相關方法 |
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2018
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2019
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2021
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