JP2020530437A5 - - Google Patents
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- Publication number
- JP2020530437A5 JP2020530437A5 JP2019570982A JP2019570982A JP2020530437A5 JP 2020530437 A5 JP2020530437 A5 JP 2020530437A5 JP 2019570982 A JP2019570982 A JP 2019570982A JP 2019570982 A JP2019570982 A JP 2019570982A JP 2020530437 A5 JP2020530437 A5 JP 2020530437A5
- Authority
- JP
- Japan
- Prior art keywords
- tumor
- neopeptides
- fusion
- recombinant poxvirus
- cancer vaccine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 238000000034 method Methods 0.000 claims 21
- 206010028980 Neoplasm Diseases 0.000 claims 17
- 230000004927 fusion Effects 0.000 claims 16
- 229940022399 cancer vaccine Drugs 0.000 claims 15
- 238000009566 cancer vaccine Methods 0.000 claims 15
- 239000000203 mixture Substances 0.000 claims 8
- 238000004519 manufacturing process Methods 0.000 claims 6
- 230000035772 mutation Effects 0.000 claims 6
- 108090000765 processed proteins & peptides Proteins 0.000 claims 5
- 108090000623 proteins and genes Proteins 0.000 claims 4
- 108010042407 Endonucleases Proteins 0.000 claims 3
- 102000004533 Endonucleases Human genes 0.000 claims 3
- 108010043121 Green Fluorescent Proteins Proteins 0.000 claims 3
- 102000004144 Green Fluorescent Proteins Human genes 0.000 claims 3
- 241000700605 Viruses Species 0.000 claims 3
- 201000011510 cancer Diseases 0.000 claims 3
- 239000005090 green fluorescent protein Substances 0.000 claims 3
- 238000002169 hydrotherapy Methods 0.000 claims 3
- 108020004707 nucleic acids Proteins 0.000 claims 3
- 102000039446 nucleic acids Human genes 0.000 claims 3
- 150000007523 nucleic acids Chemical class 0.000 claims 3
- 229960005486 vaccine Drugs 0.000 claims 3
- 108091033409 CRISPR Proteins 0.000 claims 2
- 108020004414 DNA Proteins 0.000 claims 2
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 2
- 101710163270 Nuclease Proteins 0.000 claims 2
- 108700008625 Reporter Genes Proteins 0.000 claims 2
- 241000700618 Vaccinia virus Species 0.000 claims 2
- 108010017070 Zinc Finger Nucleases Proteins 0.000 claims 2
- 125000000539 amino acid group Chemical group 0.000 claims 2
- 210000004027 cell Anatomy 0.000 claims 2
- 238000003776 cleavage reaction Methods 0.000 claims 2
- 238000009295 crossflow filtration Methods 0.000 claims 2
- 231100000221 frame shift mutation induction Toxicity 0.000 claims 2
- 230000037433 frameshift Effects 0.000 claims 2
- 201000005202 lung cancer Diseases 0.000 claims 2
- 208000020816 lung neoplasm Diseases 0.000 claims 2
- 230000007017 scission Effects 0.000 claims 2
- 230000001225 therapeutic effect Effects 0.000 claims 2
- 208000003174 Brain Neoplasms Diseases 0.000 claims 1
- 238000010354 CRISPR gene editing Methods 0.000 claims 1
- 108091026890 Coding region Proteins 0.000 claims 1
- 208000009798 Craniopharyngioma Diseases 0.000 claims 1
- 206010014967 Ependymoma Diseases 0.000 claims 1
- 241000287828 Gallus gallus Species 0.000 claims 1
- 208000021309 Germ cell tumor Diseases 0.000 claims 1
- 208000032612 Glial tumor Diseases 0.000 claims 1
- 206010018338 Glioma Diseases 0.000 claims 1
- 208000034176 Neoplasms, Germ Cell and Embryonal Diseases 0.000 claims 1
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 1
- 206010033128 Ovarian cancer Diseases 0.000 claims 1
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
- 108010076504 Protein Sorting Signals Proteins 0.000 claims 1
- 208000008938 Rhabdoid tumor Diseases 0.000 claims 1
- 206010073334 Rhabdoid tumour Diseases 0.000 claims 1
- 206010046865 Vaccinia virus infection Diseases 0.000 claims 1
- 208000009956 adenocarcinoma Diseases 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 229940124650 anti-cancer therapies Drugs 0.000 claims 1
- 238000011319 anticancer therapy Methods 0.000 claims 1
- 239000013060 biological fluid Substances 0.000 claims 1
- 238000001574 biopsy Methods 0.000 claims 1
- 238000004113 cell culture Methods 0.000 claims 1
- 210000000170 cell membrane Anatomy 0.000 claims 1
- 210000003169 central nervous system Anatomy 0.000 claims 1
- 230000002380 cytological effect Effects 0.000 claims 1
- 230000009089 cytolysis Effects 0.000 claims 1
- 230000005782 double-strand break Effects 0.000 claims 1
- 239000012636 effector Substances 0.000 claims 1
- 210000002950 fibroblast Anatomy 0.000 claims 1
- 108091006047 fluorescent proteins Proteins 0.000 claims 1
- 102000034287 fluorescent proteins Human genes 0.000 claims 1
- 208000005017 glioblastoma Diseases 0.000 claims 1
- 201000010536 head and neck cancer Diseases 0.000 claims 1
- 208000014829 head and neck neoplasm Diseases 0.000 claims 1
- 230000036039 immunity Effects 0.000 claims 1
- 230000003308 immunostimulating effect Effects 0.000 claims 1
- 238000002347 injection Methods 0.000 claims 1
- 239000007924 injection Substances 0.000 claims 1
- 230000037431 insertion Effects 0.000 claims 1
- 238000003780 insertion Methods 0.000 claims 1
- 238000007918 intramuscular administration Methods 0.000 claims 1
- 230000002601 intratumoral effect Effects 0.000 claims 1
- 238000001990 intravenous administration Methods 0.000 claims 1
- 201000009546 lung large cell carcinoma Diseases 0.000 claims 1
- 201000005243 lung squamous cell carcinoma Diseases 0.000 claims 1
- 230000036244 malformation Effects 0.000 claims 1
- 210000001161 mammalian embryo Anatomy 0.000 claims 1
- 239000000463 material Substances 0.000 claims 1
- 108020004999 messenger RNA Proteins 0.000 claims 1
- 208000002154 non-small cell lung carcinoma Diseases 0.000 claims 1
- 239000002773 nucleotide Substances 0.000 claims 1
- 125000003729 nucleotide group Chemical group 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
- 230000002685 pulmonary effect Effects 0.000 claims 1
- 238000000746 purification Methods 0.000 claims 1
- 230000022532 regulation of transcription, DNA-dependent Effects 0.000 claims 1
- 230000001105 regulatory effect Effects 0.000 claims 1
- 108091008146 restriction endonucleases Proteins 0.000 claims 1
- 230000035945 sensitivity Effects 0.000 claims 1
- 238000012163 sequencing technique Methods 0.000 claims 1
- 238000007920 subcutaneous administration Methods 0.000 claims 1
- 238000013518 transcription Methods 0.000 claims 1
- 230000035897 transcription Effects 0.000 claims 1
- 230000002103 transcriptional effect Effects 0.000 claims 1
- 230000014616 translation Effects 0.000 claims 1
- 208000007089 vaccinia Diseases 0.000 claims 1
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023100296A JP2023123609A (ja) | 2017-06-21 | 2023-06-19 | 個別化ワクチン |
| JP2025121773A JP2025160281A (ja) | 2017-06-21 | 2025-07-18 | 個別化ワクチン |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP17305760.5 | 2017-06-21 | ||
| EP17305760 | 2017-06-21 | ||
| EP18305496 | 2018-04-23 | ||
| EP18305496.4 | 2018-04-23 | ||
| PCT/EP2018/066668 WO2018234506A2 (en) | 2017-06-21 | 2018-06-21 | PERSONALIZED VACCINE |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023100296A Division JP2023123609A (ja) | 2017-06-21 | 2023-06-19 | 個別化ワクチン |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2020530437A JP2020530437A (ja) | 2020-10-22 |
| JP2020530437A5 true JP2020530437A5 (enExample) | 2021-09-24 |
| JPWO2018234506A5 JPWO2018234506A5 (enExample) | 2023-07-05 |
| JP7334124B2 JP7334124B2 (ja) | 2023-08-28 |
Family
ID=62599637
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019570982A Active JP7334124B2 (ja) | 2017-06-21 | 2018-06-21 | 個別化ワクチン |
| JP2023100296A Pending JP2023123609A (ja) | 2017-06-21 | 2023-06-19 | 個別化ワクチン |
| JP2025121773A Pending JP2025160281A (ja) | 2017-06-21 | 2025-07-18 | 個別化ワクチン |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023100296A Pending JP2023123609A (ja) | 2017-06-21 | 2023-06-19 | 個別化ワクチン |
| JP2025121773A Pending JP2025160281A (ja) | 2017-06-21 | 2025-07-18 | 個別化ワクチン |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US11969462B2 (enExample) |
| EP (1) | EP3641803A2 (enExample) |
| JP (3) | JP7334124B2 (enExample) |
| KR (2) | KR102684237B1 (enExample) |
| CN (1) | CN111065406A (enExample) |
| AU (1) | AU2018287159B2 (enExample) |
| CA (1) | CA3067405A1 (enExample) |
| IL (1) | IL271558B2 (enExample) |
| SG (1) | SG11201912429RA (enExample) |
| WO (1) | WO2018234506A2 (enExample) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3826669A2 (en) | 2018-07-26 | 2021-06-02 | Frame Pharmaceuticals B.V. | Off-the-shelf cancer vaccines |
| EP3906045A1 (en) * | 2019-01-03 | 2021-11-10 | Evaxion Biotech ApS | Vaccines targeting neoepitopes |
| TWI852977B (zh) | 2019-01-10 | 2024-08-21 | 美商健生生物科技公司 | 前列腺新抗原及其用途 |
| EP3930747A4 (en) * | 2019-02-27 | 2023-04-05 | Nektar Therapeutics | IMMUNOTHERAPEUTIC COMBINATION FOR THE TREATMENT OF CANCER |
| KR20220054819A (ko) * | 2019-08-29 | 2022-05-03 | 아스테라스 세이야쿠 가부시키가이샤 | 유전자 변형 암용해 백시니아 바이러스 및 이의 사용 방법 |
| EP4061405A1 (en) | 2019-11-18 | 2022-09-28 | Janssen Biotech, Inc. | Vaccines based on mutant calr and jak2 and their uses |
| EP3842065A1 (en) | 2019-12-23 | 2021-06-30 | Transgene | Process for designing a recombinant poxvirus for a therapeutic vaccine |
| US20230097513A1 (en) * | 2020-02-03 | 2023-03-30 | City Of Hope | Poxvirus-based vectors produced by natural or synthetic dna and uses thereof |
| CN111303277A (zh) * | 2020-02-19 | 2020-06-19 | 中国人民解放军军事科学院军事医学研究院 | 一种抗天花病毒免疫球蛋白F(ab′)2及其制备方法 |
| EP4175664A2 (en) | 2020-07-06 | 2023-05-10 | Janssen Biotech, Inc. | Prostate neoantigens and their uses |
| WO2023209068A1 (en) | 2022-04-28 | 2023-11-02 | Carbocalyx Gmbh | Personalized anticancer vaccine comprising glycoengineered tumour cells or tumour cell fragments |
| WO2024062098A1 (en) | 2022-09-23 | 2024-03-28 | Transgene | Recombinant pseudocowpox virus encoding an interleukin-12 |
| CN115927215B (zh) * | 2023-01-18 | 2025-10-17 | 中国医学科学院病原生物学研究所 | 一种定向减毒的痘苗病毒疫苗 |
| CN116656730B (zh) * | 2023-05-25 | 2024-03-19 | 军事科学院军事医学研究院军事兽医研究所 | 一种表达狂犬病病毒g、m蛋白的重组金丝雀痘病毒及其构建方法 |
Family Cites Families (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4603112A (en) | 1981-12-24 | 1986-07-29 | Health Research, Incorporated | Modified vaccinia virus |
| US7045313B1 (en) | 1982-11-30 | 2006-05-16 | The United States Of America As Represented By The Department Of Health And Human Services | Recombinant vaccinia virus containing a chimeric gene having foreign DNA flanked by vaccinia regulatory DNA |
| US5250534A (en) | 1990-06-20 | 1993-10-05 | Pfizer Inc. | Pyrazolopyrimidinone antianginal agents |
| GB9013750D0 (en) | 1990-06-20 | 1990-08-08 | Pfizer Ltd | Therapeutic agents |
| GB9311920D0 (en) | 1993-06-09 | 1993-07-28 | Pfizer Ltd | Therapeutic agents |
| UA68327C2 (en) | 1995-07-04 | 2004-08-16 | Gsf Forschungszentrum Fur Unwe | A recombinant mva virus, an isolated eukaryotic cell, infected with recombinant mva virus, a method for production in vitro of polypeptides with use of said cell, a method for production in vitro of virus parts (variants), vaccine containing the recombinant mva virus, a method for immunization of animals |
| US5672485A (en) | 1996-08-13 | 1997-09-30 | Regents Of The University Of Minnesota | Immortalized cell lines for virus growth |
| FR2766091A1 (fr) | 1997-07-18 | 1999-01-22 | Transgene Sa | Composition antitumorale a base de polypeptide immunogene de localisation cellulaire modifiee |
| FR2790955B1 (fr) | 1999-03-19 | 2003-01-17 | Assist Publ Hopitaux De Paris | Utilisation d'oligonucleotides stabilises comme principe actif antitumoral |
| UA82466C2 (uk) | 2001-07-18 | 2008-04-25 | Бавариан Нордика А/С | Спосіб посилення ампліфікації хордопоксвірусу |
| WO2003053463A2 (en) | 2001-12-10 | 2003-07-03 | Bavarian Nordic A/S | Poxvirus-containing compositions and process for their preparation |
| JP4787156B2 (ja) | 2003-07-22 | 2011-10-05 | ビバリス | 付着または非付着の鳥類細胞系を用いた、ポックスウィルスの作製法 |
| EP1528101A1 (en) | 2003-11-03 | 2005-05-04 | ProBioGen AG | Immortalized avian cell lines for virus production |
| GB0502661D0 (en) | 2005-02-09 | 2005-03-16 | Stabilitech Ltd | A desiccated product |
| AU2006315026B2 (en) | 2005-11-21 | 2012-11-22 | Sanofi Pasteur Limited | Stabilizing formulations for recombinant viruses |
| EP1979474B1 (en) | 2006-01-05 | 2010-08-11 | Transgene SA | Avian telomerase reverse transcriptase |
| KR101082296B1 (ko) | 2006-06-20 | 2011-11-09 | 트랜스진 에스.에이. | 폭스바이러스 및 폭스바이러스 조성물 제조 방법 |
| DK2118292T3 (da) | 2007-01-30 | 2011-10-24 | Transgene Sa | Papillomavirus E2-polypeptid der anvendes til vaccination |
| GB0705245D0 (en) | 2007-03-19 | 2007-04-25 | Stabilitech Ltd | Stable biological products |
| EP1985305A1 (en) | 2007-04-24 | 2008-10-29 | Vivalis | Duck embryonic derived stem cell lines for the production of viral vaccines |
| NZ578960A (en) | 2007-05-14 | 2012-11-30 | Bavarian Nordic As | Purification of vaccinia virus- and recombinant vaccinia virus-based vaccines |
| TW200844230A (en) | 2007-05-15 | 2008-11-16 | Transgene Sa | Signaling peptides |
| US8357531B2 (en) | 2007-07-03 | 2013-01-22 | Transgene S.A. | Immortalized avian cell lines |
| CN101688182A (zh) | 2007-07-03 | 2010-03-31 | 特兰斯吉恩股份有限公司 | 永生化禽细胞系 |
| CA2705873C (en) | 2007-11-19 | 2012-06-12 | Philippe Erbs | Poxviral oncolytic vectors |
| BRPI0820576B1 (pt) | 2007-11-19 | 2021-10-19 | Transgène S.A. | Uso de um poxvírus oncolítico compreendendo um gene i4l e/ou f4l defectivo ou uma composição compreendendo o mesmo |
| JP2011511640A (ja) | 2008-02-12 | 2011-04-14 | サノフィ パストゥール リミテッド | ポックス・ウイルスの精製方法 |
| EP2199400A1 (en) * | 2008-12-22 | 2010-06-23 | Emergent Product Development Germany GmbH | Single recombination system and methods of use |
| KR20120026526A (ko) | 2009-05-12 | 2012-03-19 | 트랜스진 에스.에이. | 불멸화 조류 세포주 및 그의 용도 |
| KR102315754B1 (ko) * | 2010-05-14 | 2021-10-22 | 더 제너럴 하스피톨 코포레이션 | 종양 특이적 신생항원을 확인하는 조성물 및 방법 |
| MX360823B (es) | 2011-05-24 | 2018-11-16 | Tron Translationale Onkologie An Der Univ Der Johannes Gutenberg Univ Mainz Gemeinnuetzige Gmbh | Vacunas individualizadas para el cancer. |
| JP6243333B2 (ja) | 2011-08-05 | 2017-12-06 | シラジェン バイオセラピューティクス インコーポレイテッド | ワクシニアウィルスの生成のための方法および組成物 |
| CN104662171B (zh) * | 2012-07-12 | 2018-07-13 | 普瑟姆尼股份有限公司 | 个性化癌症疫苗和过继免疫细胞治疗 |
| TWI690322B (zh) | 2012-10-02 | 2020-04-11 | 法商傳斯堅公司 | 含病毒的調配物及其使用 |
| EP4253558B1 (en) * | 2013-03-15 | 2025-07-02 | The Board of Trustees of the Leland Stanford Junior University | Identification and use of circulating nucleic acid tumor markers |
| CA2908434C (en) * | 2013-04-07 | 2021-12-28 | The Broad Institute, Inc. | Compositions and methods for personalized neoplasia vaccines |
| NZ721105A (en) * | 2013-12-06 | 2022-04-29 | Broad Inst Inc | Formulations for neoplasia vaccines |
| DK3142690T3 (da) | 2014-05-13 | 2022-05-09 | Bavarian Nordic As | Kombinationsterapi til behandling af cancer med et rekombinant poxvirus, der eksprimerer et tumorantigen, og en immun-checkpointmolekyleantagonist eller -agonist |
| AU2015259516B2 (en) | 2014-05-13 | 2020-05-28 | Bavarian Nordic A/S | Combination therapy for treating cancer with a poxvirus expressing a tumor antigen and a monoclonal antibody against TIM-3 |
| CR20200476A (es) | 2015-05-20 | 2020-12-02 | Dana Farber Cancer Inst Inc | ANTÍGENOS COMPARTIDOS (Divisional 2017-0584) |
| CA2987239A1 (en) | 2015-05-26 | 2016-12-01 | Advaxis, Inc. | Personalized delivery vector-based immunotherapy and uses thereof |
| TW202241500A (zh) * | 2015-06-09 | 2022-11-01 | 美商博德研究所有限公司 | 用於贅瘤疫苗之調配物及其製備方法 |
| EP3313975A4 (en) | 2015-06-24 | 2019-03-13 | Advaxis, Inc. | MANUFACTURING DEVICE AND METHOD FOR PERSONALIZED ADMINISTRATION OF VECTOR-BASED IMMUNOTHERAPY |
| CN108601731A (zh) * | 2015-12-16 | 2018-09-28 | 磨石肿瘤生物技术公司 | 新抗原的鉴别、制造及使用 |
| WO2017177207A1 (en) * | 2016-04-07 | 2017-10-12 | Bostongene, Llc | Construction and methods of use of a therapeutic cancer vaccine library comprising fusion-specific vaccines |
-
2018
- 2018-06-21 KR KR1020207001211A patent/KR102684237B1/ko active Active
- 2018-06-21 EP EP18731146.9A patent/EP3641803A2/en active Pending
- 2018-06-21 WO PCT/EP2018/066668 patent/WO2018234506A2/en not_active Ceased
- 2018-06-21 SG SG11201912429RA patent/SG11201912429RA/en unknown
- 2018-06-21 IL IL271558A patent/IL271558B2/en unknown
- 2018-06-21 AU AU2018287159A patent/AU2018287159B2/en active Active
- 2018-06-21 CN CN201880050941.2A patent/CN111065406A/zh active Pending
- 2018-06-21 US US16/625,239 patent/US11969462B2/en active Active
- 2018-06-21 CA CA3067405A patent/CA3067405A1/en active Pending
- 2018-06-21 KR KR1020247022788A patent/KR20240113607A/ko active Pending
- 2018-06-21 JP JP2019570982A patent/JP7334124B2/ja active Active
-
2023
- 2023-04-13 US US18/299,858 patent/US20230277639A1/en active Pending
- 2023-06-19 JP JP2023100296A patent/JP2023123609A/ja active Pending
-
2025
- 2025-07-18 JP JP2025121773A patent/JP2025160281A/ja active Pending
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