JP2020529997A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2020529997A5 JP2020529997A5 JP2020505792A JP2020505792A JP2020529997A5 JP 2020529997 A5 JP2020529997 A5 JP 2020529997A5 JP 2020505792 A JP2020505792 A JP 2020505792A JP 2020505792 A JP2020505792 A JP 2020505792A JP 2020529997 A5 JP2020529997 A5 JP 2020529997A5
- Authority
- JP
- Japan
- Prior art keywords
- mol
- mop
- cancer
- group
- ligands
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000003446 ligand Substances 0.000 claims 18
- 239000000203 mixture Substances 0.000 claims 11
- 239000013289 nano-metal-organic framework Substances 0.000 claims 10
- ROFVEXUMMXZLPA-UHFFFAOYSA-N Bipyridyl Chemical compound N1=CC=CC=C1C1=CC=CC=N1 ROFVEXUMMXZLPA-UHFFFAOYSA-N 0.000 claims 9
- 239000002955 immunomodulating agent Substances 0.000 claims 9
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 8
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Substances [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 claims 8
- 229910021645 metal ion Inorganic materials 0.000 claims 7
- 206010028980 Neoplasm Diseases 0.000 claims 6
- 239000000556 agonist Substances 0.000 claims 6
- 238000004132 cross linking Methods 0.000 claims 6
- 229910052741 iridium Inorganic materials 0.000 claims 6
- 150000004032 porphyrins Chemical group 0.000 claims 6
- 229910052707 ruthenium Inorganic materials 0.000 claims 6
- 150000002500 ions Chemical class 0.000 claims 5
- 229910052757 nitrogen Inorganic materials 0.000 claims 5
- 239000008194 pharmaceutical composition Substances 0.000 claims 5
- 229920001223 polyethylene glycol Polymers 0.000 claims 5
- 201000011510 cancer Diseases 0.000 claims 4
- 108020004201 indoleamine 2,3-dioxygenase Proteins 0.000 claims 4
- 102000006639 indoleamine 2,3-dioxygenase Human genes 0.000 claims 4
- 238000011282 treatment Methods 0.000 claims 4
- VQGHOUODWALEFC-UHFFFAOYSA-N 2-phenylpyridine Chemical compound C1=CC=CC=C1C1=CC=CC=N1 VQGHOUODWALEFC-UHFFFAOYSA-N 0.000 claims 3
- 150000004696 coordination complex Chemical class 0.000 claims 3
- 201000010099 disease Diseases 0.000 claims 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- 125000001153 fluoro group Chemical group F* 0.000 claims 3
- 239000003504 photosensitizing agent Substances 0.000 claims 3
- 229910052697 platinum Inorganic materials 0.000 claims 3
- 238000002560 therapeutic procedure Methods 0.000 claims 3
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 3
- -1 (5,5'-di (4-carboxy-phenyl) -2,2'-bipyridine) Iridium (III) chloride Chemical compound 0.000 claims 2
- 229940046168 CpG oligodeoxynucleotide Drugs 0.000 claims 2
- 101000831496 Homo sapiens Toll-like receptor 3 Proteins 0.000 claims 2
- 108010050904 Interferons Proteins 0.000 claims 2
- 229940044665 STING agonist Drugs 0.000 claims 2
- 102100024324 Toll-like receptor 3 Human genes 0.000 claims 2
- 230000000536 complexating effect Effects 0.000 claims 2
- 125000002228 disulfide group Chemical group 0.000 claims 2
- 239000003112 inhibitor Substances 0.000 claims 2
- 125000005647 linker group Chemical group 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- DWAFYCQODLXJNR-BNTLRKBRSA-L oxaliplatin Chemical compound O1C(=O)C(=O)O[Pt]11N[C@@H]2CCCC[C@H]2N1 DWAFYCQODLXJNR-BNTLRKBRSA-L 0.000 claims 2
- 229960001756 oxaliplatin Drugs 0.000 claims 2
- 229940044616 toll-like receptor 7 agonist Drugs 0.000 claims 2
- 229940044655 toll-like receptor 9 agonist Drugs 0.000 claims 2
- JFJNVIPVOCESGZ-UHFFFAOYSA-N 2,3-dipyridin-2-ylpyridine Chemical compound N1=CC=CC=C1C1=CC=CN=C1C1=CC=CC=N1 JFJNVIPVOCESGZ-UHFFFAOYSA-N 0.000 claims 1
- 150000005360 2-phenylpyridines Chemical class 0.000 claims 1
- ZQJIBJGQZQYQED-UHFFFAOYSA-L 4-[6-[5-(4-carboxyphenyl)pyridin-2-yl]pyridin-3-yl]benzoic acid 2-pyridin-2-ylpyridine ruthenium(2+) dichloride Chemical compound [Ru](Cl)Cl.C(=O)(O)C1=CC=C(C=C1)C=1C=CC(=NC1)C1=NC=C(C=C1)C1=CC=C(C=C1)C(=O)O.N1=C(C=CC=C1)C1=NC=CC=C1.N1=C(C=CC=C1)C1=NC=CC=C1 ZQJIBJGQZQYQED-UHFFFAOYSA-L 0.000 claims 1
- 206010005003 Bladder cancer Diseases 0.000 claims 1
- 208000003174 Brain Neoplasms Diseases 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 206010009944 Colon cancer Diseases 0.000 claims 1
- 208000009849 Female Genital Neoplasms Diseases 0.000 claims 1
- 229940076838 Immune checkpoint inhibitor Drugs 0.000 claims 1
- 108091008026 Inhibitory immune checkpoint proteins Proteins 0.000 claims 1
- 102000037984 Inhibitory immune checkpoint proteins Human genes 0.000 claims 1
- 208000008839 Kidney Neoplasms Diseases 0.000 claims 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
- 208000034578 Multiple myelomas Diseases 0.000 claims 1
- 206010029260 Neuroblastoma Diseases 0.000 claims 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
- 208000015634 Rectal Neoplasms Diseases 0.000 claims 1
- 206010038389 Renal cancer Diseases 0.000 claims 1
- 208000016624 Retinal neoplasm Diseases 0.000 claims 1
- KJTLSVCANCCWHF-UHFFFAOYSA-N Ruthenium Chemical group [Ru] KJTLSVCANCCWHF-UHFFFAOYSA-N 0.000 claims 1
- 206010039491 Sarcoma Diseases 0.000 claims 1
- 208000000453 Skin Neoplasms Diseases 0.000 claims 1
- 208000021712 Soft tissue sarcoma Diseases 0.000 claims 1
- 208000005718 Stomach Neoplasms Diseases 0.000 claims 1
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims 1
- DGEZNRSVGBDHLK-UHFFFAOYSA-N [1,10]phenanthroline Chemical compound C1=CN=C2C3=NC=CC=C3C=CC2=C1 DGEZNRSVGBDHLK-UHFFFAOYSA-N 0.000 claims 1
- QYKMXTVPHUMWJW-UHFFFAOYSA-N [Ir].C(=O)(O)C1=CC=C(C=C1)C=1C=CC(=NC1)C1=NC=C(C=C1)C1=CC=C(C=C1)C(=O)O Chemical compound [Ir].C(=O)(O)C1=CC=C(C=C1)C=1C=CC(=NC1)C1=NC=C(C=C1)C1=CC=C(C=C1)C(=O)O QYKMXTVPHUMWJW-UHFFFAOYSA-N 0.000 claims 1
- 229910052797 bismuth Inorganic materials 0.000 claims 1
- 150000007942 carboxylates Chemical class 0.000 claims 1
- 201000007455 central nervous system cancer Diseases 0.000 claims 1
- 238000002512 chemotherapy Methods 0.000 claims 1
- SURLGNKAQXKNSP-DBLYXWCISA-N chlorin Chemical group C\1=C/2\N/C(=C\C3=N/C(=C\C=4NC(/C=C\5/C=CC/1=N/5)=CC=4)/C=C3)/CC\2 SURLGNKAQXKNSP-DBLYXWCISA-N 0.000 claims 1
- 229930002875 chlorophyll Chemical group 0.000 claims 1
- 235000019804 chlorophyll Nutrition 0.000 claims 1
- ATNHDLDRLWWWCB-AENOIHSZSA-M chlorophyll a Chemical group C1([C@@H](C(=O)OC)C(=O)C2=C3C)=C2N2C3=CC(C(CC)=C3C)=[N+]4C3=CC3=C(C=C)C(C)=C5N3[Mg-2]42[N+]2=C1[C@@H](CCC(=O)OC\C=C(/C)CCC[C@H](C)CCC[C@H](C)CCCC(C)C)[C@H](C)C2=C5 ATNHDLDRLWWWCB-AENOIHSZSA-M 0.000 claims 1
- 208000029742 colonic neoplasm Diseases 0.000 claims 1
- 201000010918 connective tissue cancer Diseases 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- JVZRCNQLWOELDU-UHFFFAOYSA-N gamma-Phenylpyridine Natural products C1=CC=CC=C1C1=CC=NC=C1 JVZRCNQLWOELDU-UHFFFAOYSA-N 0.000 claims 1
- 206010017758 gastric cancer Diseases 0.000 claims 1
- 230000002068 genetic effect Effects 0.000 claims 1
- 210000004392 genitalia Anatomy 0.000 claims 1
- 229910052737 gold Inorganic materials 0.000 claims 1
- 229910052735 hafnium Inorganic materials 0.000 claims 1
- 125000001188 haloalkyl group Chemical group 0.000 claims 1
- 125000005843 halogen group Chemical group 0.000 claims 1
- 201000005787 hematologic cancer Diseases 0.000 claims 1
- 208000024200 hematopoietic and lymphoid system neoplasm Diseases 0.000 claims 1
- 239000012274 immune-checkpoint protein inhibitor Substances 0.000 claims 1
- 230000005865 ionizing radiation Effects 0.000 claims 1
- GKOZUEZYRPOHIO-UHFFFAOYSA-N iridium atom Chemical compound [Ir] GKOZUEZYRPOHIO-UHFFFAOYSA-N 0.000 claims 1
- MILUBEOXRNEUHS-UHFFFAOYSA-N iridium(3+) Chemical compound [Ir+3] MILUBEOXRNEUHS-UHFFFAOYSA-N 0.000 claims 1
- 201000010982 kidney cancer Diseases 0.000 claims 1
- 229910052747 lanthanoid Inorganic materials 0.000 claims 1
- 150000002602 lanthanoids Chemical class 0.000 claims 1
- 229910052745 lead Inorganic materials 0.000 claims 1
- 201000005202 lung cancer Diseases 0.000 claims 1
- 208000020816 lung neoplasm Diseases 0.000 claims 1
- 210000002751 lymph Anatomy 0.000 claims 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 1
- 229910052751 metal Inorganic materials 0.000 claims 1
- 239000002184 metal Substances 0.000 claims 1
- 208000037819 metastatic cancer Diseases 0.000 claims 1
- 208000011575 metastatic malignant neoplasm Diseases 0.000 claims 1
- 239000002055 nanoplate Substances 0.000 claims 1
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 1
- 239000012044 organic layer Substances 0.000 claims 1
- 229910052762 osmium Inorganic materials 0.000 claims 1
- 201000002528 pancreatic cancer Diseases 0.000 claims 1
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 1
- 230000000737 periodic effect Effects 0.000 claims 1
- IEQIEDJGQAUEQZ-UHFFFAOYSA-N phthalocyanine Chemical group N1C(N=C2C3=CC=CC=C3C(N=C3C4=CC=CC=C4C(=N4)N3)=N2)=C(C=CC=C2)C2=C1N=C1C2=CC=CC=C2C4=N1 IEQIEDJGQAUEQZ-UHFFFAOYSA-N 0.000 claims 1
- 239000000651 prodrug Substances 0.000 claims 1
- 229940002612 prodrug Drugs 0.000 claims 1
- 206010038038 rectal cancer Diseases 0.000 claims 1
- 201000001275 rectum cancer Diseases 0.000 claims 1
- 201000008933 retinal cancer Diseases 0.000 claims 1
- 229910052702 rhenium Inorganic materials 0.000 claims 1
- 201000000849 skin cancer Diseases 0.000 claims 1
- 201000011549 stomach cancer Diseases 0.000 claims 1
- 238000001356 surgical procedure Methods 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
- 239000003053 toxin Substances 0.000 claims 1
- 231100000765 toxin Toxicity 0.000 claims 1
- 229910052721 tungsten Inorganic materials 0.000 claims 1
- 201000005112 urinary bladder cancer Diseases 0.000 claims 1
- 208000024719 uterine cervix neoplasm Diseases 0.000 claims 1
- 0 *C([C@@](*1)C(*)=C(*)C=I)c2c1c(*)c(*)cn2 Chemical compound *C([C@@](*1)C(*)=C(*)C=I)c2c1c(*)c(*)cn2 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762540275P | 2017-08-02 | 2017-08-02 | |
| US62/540,275 | 2017-08-02 | ||
| US201862623826P | 2018-01-30 | 2018-01-30 | |
| US62/623,826 | 2018-01-30 | ||
| PCT/US2018/045005 WO2019028250A1 (en) | 2017-08-02 | 2018-08-02 | NOMOGENEOUS ORGANOMETALLIC ORGANOMETRIC ORGANOMETRIC LAYERS FOR X-RAY INDUCED PHOTODYNAMIC THERAPY, RADIOTHERAPY, RODIODYNAMIC THERAPY, CHEMOTHERAPY, IMMUNOTHERAPY, AND ANY COMBINATION THEREOF |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020529997A JP2020529997A (ja) | 2020-10-15 |
| JP2020529997A5 true JP2020529997A5 (enExample) | 2021-09-09 |
| JP7364552B2 JP7364552B2 (ja) | 2023-10-18 |
Family
ID=65233051
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020505792A Active JP7364552B2 (ja) | 2017-08-02 | 2018-08-02 | Ｘ線誘起光線力学療法、放射線療法、放射線力学療法、化学療法、免疫療法、及びそれらの任意の組み合わせのための、ナノスケール金属有機層及び金属有機ナノプレート |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US11826426B2 (enExample) |
| EP (1) | EP3638367A4 (enExample) |
| JP (1) | JP7364552B2 (enExample) |
| CN (1) | CN111194232B (enExample) |
| WO (1) | WO2019028250A1 (enExample) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3494974B1 (en) | 2011-07-08 | 2023-10-18 | The University of North Carolina at Chapel Hill | Metal bisphosphonate nanoparticles for anti-cancer therapy and imaging and for treating bone disorders |
| WO2019028250A1 (en) | 2017-08-02 | 2019-02-07 | The University Of Chicago | NOMOGENEOUS ORGANOMETALLIC ORGANOMETRIC ORGANOMETRIC LAYERS FOR X-RAY INDUCED PHOTODYNAMIC THERAPY, RADIOTHERAPY, RODIODYNAMIC THERAPY, CHEMOTHERAPY, IMMUNOTHERAPY, AND ANY COMBINATION THEREOF |
| US20190314324A1 (en) | 2018-04-13 | 2019-10-17 | The University Of Chicago | Combination of micheliolide derivatives or nanoparticles with ionizing radiation and checkpoint inhibitors for cancer therapy |
| KR20260012291A (ko) | 2018-07-12 | 2026-01-26 | 더 리젠츠 오브 더 유니버시티 오브 미시간 | 면역 반응을 조절할 수 있는 금속 함유 제형의 조성물 및 방법 |
| CN110256482B (zh) * | 2019-06-19 | 2021-04-06 | 吉林大学 | 一种杂多钒酸盐化合物及其制备方法 |
| CN110227157A (zh) * | 2019-06-21 | 2019-09-13 | 南开大学 | 掺钆硅纳米粒子/光敏剂自组装金属有机框架纳米材料的制备方法 |
| CN116744909A (zh) * | 2020-05-22 | 2023-09-12 | 芝加哥大学 | 金属有机框架递送小分子和生物大分子用于癌症免疫治疗 |
| WO2021237209A1 (en) * | 2020-05-22 | 2021-11-25 | The University Of Chicago | Metal-organic frameworks deliver small molecules and biomacromolecules for cancer immunotherapy |
| CN111939124B (zh) * | 2020-07-13 | 2022-06-28 | 东南大学 | 一种金属聚合物、金属聚合物纳米胶束及其制备方法和应用 |
| CN111804346B (zh) * | 2020-07-17 | 2023-09-12 | 中国人民解放军国防科技大学 | 一种快速制备金属有机层材料的方法及应用 |
| CN112007170B (zh) * | 2020-08-14 | 2023-06-13 | 南方医科大学皮肤病医院（广东省皮肤病医院、广东省皮肤性病防治中心、中国麻风防治研究中心） | 免疫佐剂功能化金属有机框架材料及其制备方法与应用 |
| CN112294956B (zh) * | 2020-11-13 | 2023-05-05 | 中山大学 | 一种金属铱光敏剂及其制备方法和应用 |
| EP4255488A1 (en) | 2020-12-01 | 2023-10-11 | Nanobiotix | Porous, high-z and carbon-free particles as radioenhancers |
| CN113754699B (zh) * | 2021-09-08 | 2024-06-14 | 上海市质子重离子临床技术研发中心 | 一种铱配合物聚集体在制备放射动力学药物中的应用及制备方法 |
| CN114106060B (zh) * | 2021-09-08 | 2024-02-27 | 上海市质子重离子临床技术研发中心 | 一种基于铱配合物的双金属中心化合物在制备放射动力学药物中的应用及其制备方法 |
| CN114805826B (zh) * | 2022-03-11 | 2023-03-21 | 湖北工业大学 | 一种Eu3+功能化MOF荧光探针及其制备方法和检测四环素类药物的应用 |
| CN115575372A (zh) * | 2022-10-27 | 2023-01-06 | 浙江清华柔性电子技术研究院 | 氧传感器荧光膜的制作方法、氧传感器荧光膜及氧传感器 |
| AR131316A1 (es) | 2022-12-12 | 2025-03-05 | Nanobiotix S A | Novedosas nanopartículas de óxido de metal y composiciones de las mismas para uso como radiopotenciadores o para visualizar tejido biológico |
| CN118812426B (zh) * | 2023-04-18 | 2025-12-12 | 中国科学技术大学 | 二价金属阳离子化合物及其制备方法和应用 |
| CN116270544B (zh) * | 2023-05-23 | 2023-08-01 | 深圳市第二人民医院(深圳市转化医学研究院) | 铂卟啉纳米材料及其制备方法 |
| CN117338930B (zh) * | 2023-11-03 | 2026-03-17 | 海南大学 | Bp/PCN-224/Fe3O4纳米异质结的制备及应用 |
| CN118671344B (zh) * | 2024-07-01 | 2025-04-22 | 威特曼医学检验(南京)有限公司 | 一种测定甲胎蛋白含量的均相化学发光试剂盒 |
| CN119119328A (zh) * | 2024-09-04 | 2024-12-13 | 江南大学 | 一种用于近红外光固化的负载光引发剂上转换MOFs复合材料及其制备方法 |
| CN120381439B (zh) * | 2025-02-24 | 2026-04-24 | 苏州大学 | 一种基于吡啶基卟啉的聚乙二醇化的纳米颗粒及其制备方法与应用 |
Family Cites Families (112)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL61351A (en) | 1980-10-27 | 1983-12-30 | Yeda Res & Dev | Organometallic polymers,their preparation and compositions of co-ordination compounds containing them |
| US5147806A (en) | 1988-04-29 | 1992-09-15 | Igen, Inc. | Method and apparatus for conducting electrochemiluminescence measurements |
| US5213788A (en) | 1988-09-29 | 1993-05-25 | Ranney David F | Physically and chemically stabilized polyatomic clusters for magnetic resonance image and spectral enhancement |
| ES2084825T3 (es) | 1990-07-26 | 1996-05-16 | Monsanto Co | Procedimiento de preparacion de poliamidas entrecruzadas. |
| US6013638A (en) | 1991-10-02 | 2000-01-11 | The United States Of America As Represented By The Department Of Health And Human Services | Adenovirus comprising deletions on the E1A, E1B and E3 regions for transfer of genes to the lung |
| US5858784A (en) | 1991-12-17 | 1999-01-12 | The Regents Of The University Of California | Expression of cloned genes in the lung by aerosol- and liposome-based delivery |
| US5871710A (en) | 1992-09-04 | 1999-02-16 | The General Hospital Corporation | Graft co-polymer adducts of platinum (II) compounds |
| US5591730A (en) | 1993-10-12 | 1997-01-07 | The Regents Of The University Of California | Inhibition of urinary calculi growth |
| US5641623A (en) | 1995-01-04 | 1997-06-24 | Martin; Mark T. | Electrochemiluminescence assay |
| US20010003647A1 (en) | 1995-06-07 | 2001-06-14 | Ji Sun | Coreatant-including electrochemiluminescent compounds, methods, systems and kits utilizing same |
| US6022737A (en) | 1995-11-02 | 2000-02-08 | Amgen Inc. | Formulations for non-viral in vivo transfection in the lungs |
| US5648508A (en) | 1995-11-22 | 1997-07-15 | Nalco Chemical Company | Crystalline metal-organic microporous materials |
| US5874064A (en) | 1996-05-24 | 1999-02-23 | Massachusetts Institute Of Technology | Aerodynamically light particles for pulmonary drug delivery |
| KR100483256B1 (ko) | 1997-01-24 | 2005-04-15 | 콘파마 아에스 | 젬시타빈 유도체 |
| US6180082B1 (en) | 1997-11-24 | 2001-01-30 | Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | Method to enhance tissue accumulation of radiolabeled compounds |
| US6984400B2 (en) | 1998-07-14 | 2006-01-10 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Method of treating restenosis using bisphosphonate nanoparticles |
| US6818227B1 (en) | 1999-02-08 | 2004-11-16 | Alza Corporation | Liposome composition and method for administration of a radiosensitizer |
| EP1161226B1 (en) | 1999-02-18 | 2004-05-26 | SuperGen, Inc. | Phosphocholine linked prodrug derivatives |
| US20020064520A1 (en) | 1999-08-19 | 2002-05-30 | Yanina Rozenberg | Targeted artificial gene delivery |
| WO2001022972A2 (en) | 1999-09-25 | 2001-04-05 | University Of Iowa Research Foundation | Immunostimulatory nucleic acids |
| US6602932B2 (en) | 1999-12-15 | 2003-08-05 | North Carolina State University | Nanoparticle composites and nanocapsules for guest encapsulation and methods for synthesizing same |
| WO2001076577A2 (en) | 2000-04-07 | 2001-10-18 | The Board Of Regents Of The University Of Texas System | Unique compositions of zwitterionic phospholipids and bisphosphonates and use of the compositions as bisphosphate delivery systems with reduced gi toxicity |
| US6548264B1 (en) | 2000-05-17 | 2003-04-15 | University Of Florida | Coated nanoparticles |
| US6565873B1 (en) | 2000-10-25 | 2003-05-20 | Salvona Llc | Biodegradable bioadhesive controlled release system of nano-particles for oral care products |
| US20020127224A1 (en) | 2001-03-02 | 2002-09-12 | James Chen | Use of photoluminescent nanoparticles for photodynamic therapy |
| ES2269761T3 (es) | 2001-04-30 | 2007-04-01 | The Regents Of The University Of Michigan | Estructuras organometalicas isorreticulares, procedimiento para su formacion, y diseño sistematico del calibre de poros y funcionalidad de los mismos, con aplicacion para el almacenamiento de gases. |
| AU2003226082A1 (en) | 2002-03-25 | 2003-11-11 | The General Hospital Corporation | Methods of adjuvant photodynamic therapy to enhance radiation sensitization |
| EP1542662A1 (en) | 2002-09-28 | 2005-06-22 | McNEIL-PPC, INC. | Immediate release dosage form comprising shell having openings therein |
| WO2004041203A2 (en) | 2002-11-04 | 2004-05-21 | Xenoport, Inc. | Gemcitabine prodrugs, pharmaceutical compositions and uses thereof |
| KR100401335B1 (en) | 2003-03-08 | 2003-10-10 | Mijitech Co Ltd | Metal nanoparticle surface-coated with silicon oxides and preparation thereof |
| US6878838B2 (en) | 2003-03-24 | 2005-04-12 | The University Of North Carolina At Chapel Hill | Chiral porous metal phosphonates for heterogeneous asymmetric catalysis |
| CA2518223A1 (en) | 2003-03-26 | 2004-10-07 | Ltt Bio-Pharma Co., Ltd. | Intravenous nanoparticles for targeting drug delivery and sustained drug release |
| WO2004089345A1 (en) | 2003-04-03 | 2004-10-21 | Semafore Pharmaceuticals Inc. | Bone targeting of biodegradable drug-containing nanoparticles |
| KR101186764B1 (ko) | 2003-05-09 | 2012-09-28 | 더 리젠츠 오브 더 유니버시티 오브 미시간 | 결정들에서 우수한 수준의 표면적과 다공성의 성취를 위한 방법의 이행 |
| CA2533128A1 (en) | 2003-07-31 | 2005-02-10 | 3M Innovative Properties Company | Bioactive compositions comprising triazines |
| EP1670512A2 (en) * | 2003-09-23 | 2006-06-21 | Light Sciences Corporation | Singlet oxygen photosensitizers activated by target binding enhancing the selectivity of targeted pdt agents |
| US20050227929A1 (en) | 2003-11-13 | 2005-10-13 | Masferrer Jaime L | Combination therapy comprising a Cox-2 inhibitor and an antineoplastic agent |
| US20050147963A1 (en) | 2003-12-29 | 2005-07-07 | Intel Corporation | Composite organic-inorganic nanoparticles and methods for use thereof |
| WO2005092195A1 (ja) | 2004-03-29 | 2005-10-06 | National Institute Of Radiological Sciences | ヒール効果補正フィルタ、ｘ線照射装置、ｘ線ｃｔ装置及びｘ線ｃｔ撮像方法 |
| US20070259966A1 (en) | 2004-04-22 | 2007-11-08 | Allos Therapeutics, Inc. | Coadministration of Radiation, Efaproxiral Sodium, and Supplemental Oxygen for the Treatment of Cancer |
| FR2869803B1 (fr) | 2004-05-10 | 2006-07-28 | Nanobiotix Sarl | Particules activables, preparation et utilisations |
| FR2874016B1 (fr) | 2004-06-30 | 2006-11-24 | Centre Nat Rech Scient Cnrse | Nanoparticules de derives de la gemcitabine |
| US7964571B2 (en) | 2004-12-09 | 2011-06-21 | Egen, Inc. | Combination of immuno gene therapy and chemotherapy for treatment of cancer and hyperproliferative diseases |
| US20070218049A1 (en) | 2006-02-02 | 2007-09-20 | Wei Chen | Nanoparticle based photodynamic therapy and methods of making and using same |
| EP1865935B1 (en) | 2005-02-17 | 2011-06-08 | Hadasit Medical Research Services and Development Ltd. | Bisphosphonates for treating endometriosis |
| CN1305937C (zh) | 2005-02-25 | 2007-03-21 | 复旦大学 | 一种金属配位聚合物纳米结构材料的制备方法 |
| WO2006102117A1 (en) | 2005-03-17 | 2006-09-28 | Elan Pharma International Limited | Nanoparticulate biphosphonate compositions |
| NO322682B1 (no) | 2005-03-18 | 2006-11-27 | Clavis Pharma Asa | Anvendelse av gemcitabinderivater for fremstilling av orale doseringsformer ved kreftbehandling, samt slike orale doseringsformer |
| PE20070360A1 (es) | 2005-09-01 | 2007-04-19 | Novartis Ag | Composiciones de liposomas |
| US20080095699A1 (en) | 2006-10-20 | 2008-04-24 | Shiying Zheng | Imaging contrast agents using nanoparticles |
| US7263170B2 (en) | 2005-09-30 | 2007-08-28 | Pellegrino Anthony J | Radiation therapy system featuring rotatable filter assembly |
| US20070088161A1 (en) | 2005-10-19 | 2007-04-19 | Stockel Richard F | Novel chelated bisphosphonates for use as pharmaceutical agents |
| CA2641785C (en) | 2006-02-09 | 2016-05-31 | Simon Fraser University | Birefringent metal-containing coordination polymers |
| US20100189222A1 (en) | 2006-02-16 | 2010-07-29 | Steller Micro Devices | Panoramic irradiation system using flat panel x-ray sources |
| KR100943923B1 (ko) | 2006-03-17 | 2010-02-24 | 홍순해 | 킬레이팅 유기 고분자와 생물학적 금속으로 이루어진 나노입자, 그리고 ｅｐｒ 효과를 이용한 새로운 광범위 무독성항암제 및 그 제조 방법 |
| US20090317335A1 (en) | 2006-04-20 | 2009-12-24 | Wenbin Lin | Hybrid Nanomaterials as Multimodal Imaging Contrast Agents |
| GB0613362D0 (en) * | 2006-07-05 | 2006-08-16 | Hemocorm Ltd | Therapeutic delivery of carbon monoxide |
| WO2008010263A1 (fr) | 2006-07-18 | 2008-01-24 | Mitsubishi Electric Corporation | Procédé de production d'une électrode pour le traitement de surface par décharge et procédé de traitement de surface par décharge |
| WO2008016172A1 (fr) | 2006-08-04 | 2008-02-07 | Kurume University | Inhibiteur de métastase |
| US7985868B1 (en) | 2006-11-01 | 2011-07-26 | Sandia Corporation | Hybrid metal organic scintillator materials system and particle detector |
| US20080124281A1 (en) | 2006-11-29 | 2008-05-29 | Board Of Regents, The University Of Texas System | Nanotubular probes as ultrasensitive mr contrast agent |
| FR2910009B1 (fr) * | 2006-12-19 | 2009-03-06 | Commissariat Energie Atomique | Procede de preparation d'un film organique a la surface d'un support solide dans des conditions non-electrochimiques, su pport solide ainsi obtenu et kit de preparation |
| WO2008102632A1 (ja) | 2007-02-21 | 2008-08-28 | Konica Minolta Medical & Graphic, Inc. | Ｘ線バンドパスフィルタ、ｘ線照射システム及びｘ線撮影システム |
| US20090074828A1 (en) | 2007-04-04 | 2009-03-19 | Massachusetts Institute Of Technology | Poly(amino acid) targeting moieties |
| KR20090001013A (ko) * | 2007-06-29 | 2009-01-08 | 주식회사 웰스킨 | 인돌-3-알킬카복실산을 함유하는 여드름 치료제 및 피지분비 억제제, 및 이를 포함하는 광역학적 치료용 키트 |
| US8486452B2 (en) | 2007-07-20 | 2013-07-16 | Mylan Pharmaceuticals Inc. | Stabilized tolterodine tartrate formulations |
| WO2009042802A1 (en) | 2007-09-25 | 2009-04-02 | The Regents Of The University Of California | Edible and biocompatible metal-organic frameworks |
| FR2921838A1 (fr) | 2007-10-05 | 2009-04-10 | Guerbet Sa | Nouveau procede de preparation de nanoparticules recouvertes d'une couche stabilisatrice gem-bisphosphonate couplee a des ligands de biodistribution hydrophile |
| WO2009139939A2 (en) * | 2008-02-22 | 2009-11-19 | The University Of North Carolina At Chapel Hill | Hybrid nanoparticles as anti-cancer therapeutic agents and dual therapeutic/imaging contrast agents |
| US20110053862A1 (en) | 2008-03-12 | 2011-03-03 | Intradigm Corporation | Compositions comprising survivin sirna and methods of use thereof |
| GB0807862D0 (en) | 2008-04-29 | 2008-06-04 | Uni I Oslo | Compounds |
| US8968705B2 (en) | 2008-08-22 | 2015-03-03 | Colorado School Of Mines | Gold/lanthanide nanoparticle conjugates and uses thereof |
| JP5964589B2 (ja) | 2008-12-03 | 2016-08-03 | シナジー ファーマシューティカルズ インコーポレイテッド | グアニル酸シクラーゼｃアゴニストの製剤およびその使用方法 |
| EP2198885B1 (en) * | 2008-12-19 | 2012-02-08 | Biolitec AG | Calcium phosphate nanoparticles as dye carrier for photodynamic therapy |
| US9302003B2 (en) | 2009-04-24 | 2016-04-05 | Socpra—Sciences Santé´Et Humaines | Compositions comprising a radiosensitizer and an anti-cancer agent and methods of uses thereof |
| AU2010252280A1 (en) | 2009-05-25 | 2012-01-19 | Merck Patent Gmbh | Continuous administration of cilengitide in cancer treatments |
| EP2438076B1 (en) | 2009-06-05 | 2018-12-19 | Nanyang Technological University | Targeted drug delivery to the bone |
| GB0914287D0 (en) | 2009-08-14 | 2009-09-30 | Pci Biotech As | Compositions |
| WO2011049743A1 (en) | 2009-10-06 | 2011-04-28 | Stellarray, Inc. | Self contained irradiation system using flat panel x-ray sources |
| CA2776796C (en) | 2009-10-16 | 2018-11-13 | University Health Network | Porphyrin nanovesicles |
| RU2012125350A (ru) | 2009-11-20 | 2013-12-27 | Клавис Фарма Аса | Парентеральные препараты производных гемцитабина |
| GB201013307D0 (en) | 2010-08-09 | 2010-09-22 | Univ St Andrews | Anti-microbial metal organic framework |
| IT1401882B1 (it) | 2010-10-01 | 2013-08-28 | Rosa De | Nanoparticelle autoassemblanti per il rilascio di bifosfonati nel trattamento di tumori. |
| WO2012138419A1 (en) | 2011-04-04 | 2012-10-11 | Georgia Tech Research Corporation | Mof nanocrystals |
| NO2694640T3 (enExample) | 2011-04-15 | 2018-03-17 | ||
| US20120301537A1 (en) | 2011-05-23 | 2012-11-29 | Delta-Fly Pharma, Inc. | LIPOSOME CONTAINING shRNA MOLECULE TARGETING A THYMIDYLATE SYNTHASE AND USE THEREOF |
| CN103857384B (zh) | 2011-06-06 | 2017-07-11 | 大学健康网络 | 用于合成卟啉‑磷脂结合物的方法 |
| EP2721032A4 (en) | 2011-06-16 | 2014-11-05 | Univ South Florida | POLYHEDRIC CAGE WITH METAL OPORPHYRENE EQUIPMENT, METHOD FOR THE PRODUCTION THEREOF AND METHOD FOR THEIR USE |
| EP3494974B1 (en) | 2011-07-08 | 2023-10-18 | The University of North Carolina at Chapel Hill | Metal bisphosphonate nanoparticles for anti-cancer therapy and imaging and for treating bone disorders |
| US9517277B2 (en) | 2011-07-15 | 2016-12-13 | University Of Georgia Research Foundation, Inc. | Immune-stimulating photoactive hybrid nanoparticles |
| ES2856698T3 (es) * | 2011-08-23 | 2021-09-28 | Yeda Res & Dev | Fotosensibilizadores de (bacterio)clorofila para el tratamiento de enfermedades y trastornos oculares |
| CN102432654A (zh) | 2011-09-26 | 2012-05-02 | 宋云龙 | 吉西他滨酰胺衍生物及其制备方法和用途 |
| WO2013068965A2 (en) | 2011-11-11 | 2013-05-16 | Koninklijke Philips Electronics N.V. | Lighting apparatus and manufacturing method for manufacturing the lighting apparatus |
| JP6042450B2 (ja) | 2011-12-16 | 2016-12-14 | ナノビオティックスＮａｎｏｂｉｏｔｉｘ | 金属材料および酸化ハフニウム材料を含むナノ粒子、その製造および使用 |
| US20130209755A1 (en) * | 2012-02-15 | 2013-08-15 | Phillip Dene Hustad | Self-assembled structures, method of manufacture thereof and articles comprising the same |
| JP6427097B2 (ja) | 2012-06-15 | 2018-11-21 | ザ ブリガム アンド ウィメンズ ホスピタル インコーポレイテッドＴｈｅ Ｂｒｉｇｈａｍ ａｎｄ Ｗｏｍｅｎ’ｓ Ｈｏｓｐｉｔａｌ， Ｉｎｃ． | 癌を処置するための組成物および該組成物を製造するための方法 |
| DK2944323T3 (en) | 2013-01-11 | 2019-04-15 | Dingfu Biotarget Co Ltd | Means for the treatment of tumors, their use and their method |
| US10350275B2 (en) | 2013-09-21 | 2019-07-16 | Advantagene, Inc. | Methods of cytotoxic gene therapy to treat tumors |
| CN105873569B (zh) | 2013-11-06 | 2020-07-28 | 芝加哥大学 | 用于化疗剂、核酸和光敏剂的递送或共递送的纳米级载体 |
| WO2015149072A1 (en) | 2014-03-28 | 2015-10-01 | The University Of Chicago | Metal-organic frameworks containing nitrogen-donor ligands for efficient catalytic organic transformations |
| WO2015149068A1 (en) | 2014-03-28 | 2015-10-01 | The University Of Chicago | Chiral ligand-based metal-organic frameworks for broad-scope asymmetric catalysis |
| US10806694B2 (en) | 2014-10-14 | 2020-10-20 | The University Of Chicago | Nanoparticles for photodynamic therapy, X-ray induced photodynamic therapy, radiotherapy, radiodynamic therapy, chemotherapy, immunotherapy, and any combination thereof |
| US10206871B2 (en) | 2014-10-14 | 2019-02-19 | The University Of Chicago | Nanoparticles for photodynamic therapy, X-ray induced photodynamic therapy, radiotherapy, chemotherapy, immunotherapy, and any combination thereof |
| WO2017023667A1 (en) | 2015-07-31 | 2017-02-09 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Immunostimulatory nanocarrier |
| WO2017066328A1 (en) | 2015-10-12 | 2017-04-20 | The University Of Chicago | Stabilization of active metal catalysts at metal-organic framework nodes for highly efficient organic transformations |
| CN105457038A (zh) | 2015-11-09 | 2016-04-06 | 东南大学 | 一种速释型药物磷脂化合物及其药物组合物 |
| CN109310702A (zh) | 2016-05-20 | 2019-02-05 | 芝加哥大学 | 用于化学疗法、靶向疗法、光动力疗法、免疫疗法和它们的任何组合的纳米颗粒 |
| CN109562355A (zh) | 2016-08-18 | 2019-04-02 | 芝加哥大学 | 用于高效有机转化的金属氧化物负载的地球丰富的金属催化剂 |
| WO2019028250A1 (en) | 2017-08-02 | 2019-02-07 | The University Of Chicago | NOMOGENEOUS ORGANOMETALLIC ORGANOMETRIC ORGANOMETRIC LAYERS FOR X-RAY INDUCED PHOTODYNAMIC THERAPY, RADIOTHERAPY, RODIODYNAMIC THERAPY, CHEMOTHERAPY, IMMUNOTHERAPY, AND ANY COMBINATION THEREOF |
| US20190314324A1 (en) | 2018-04-13 | 2019-10-17 | The University Of Chicago | Combination of micheliolide derivatives or nanoparticles with ionizing radiation and checkpoint inhibitors for cancer therapy |
| US12042788B2 (en) | 2019-08-21 | 2024-07-23 | The University Of Chicago | Strongly Lewis acidic metal-organic frameworks for continuous flow catalysis |
| WO2021237209A1 (en) | 2020-05-22 | 2021-11-25 | The University Of Chicago | Metal-organic frameworks deliver small molecules and biomacromolecules for cancer immunotherapy |
-
2018
- 2018-08-02 WO PCT/US2018/045005 patent/WO2019028250A1/en not_active Ceased
- 2018-08-02 US US16/634,486 patent/US11826426B2/en active Active
- 2018-08-02 EP EP18840272.1A patent/EP3638367A4/en active Pending
- 2018-08-02 JP JP2020505792A patent/JP7364552B2/ja active Active
- 2018-08-02 CN CN201880064003.8A patent/CN111194232B/zh not_active Expired - Fee Related
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| TWI869913B (zh) | 吡啶并[4,3-d]嘧啶化合物 | |
| ES2881622T3 (es) | Compuestos de pirimidina, su método de preparación y usos farmacéuticos de los mismos | |
| CN105683201B (zh) | 新的含n‑杂环碳烯配体的金(iii)络合物、合成及其在癌症治疗和硫醇检测中的应用 | |
| RU2018105655A (ru) | Комбинированная терапия с применением липосомального иринотекана и ингибитора parp для лечения рака | |
| Milutinović et al. | Newly synthesized heteronuclear ruthenium (II)/ferrocene complexes suppress the growth of mammary carcinoma in 4T1-treated BALB/c mice by promoting activation of antitumor immunity | |
| JP2016514103A5 (ja) | 細胞結合剤及び細胞毒性剤としてのマイタンシノイドを含む複合体 | |
| MX2013008749A (es) | Agente terapeutico o profilactico para caquexia. | |
| JP7304128B2 (ja) | 白金耐性の克服における使用のためのテキサフィリン－白金（ｉｖ）コンジュゲート及び組成物 | |
| WO2014142220A1 (ja) | 抗腫瘍剤 | |
| TW202417055A (zh) | 抗ｓｅｚ６抗體藥物接合物 | |
| JP2024147816A (ja) | がん治療における免疫モジュレーションのための組合せ | |
| CN117157106A (zh) | 药物在治疗肿瘤疾病中的应用 | |
| EP2920187A1 (en) | A method of using binuclear gold(i) compounds for cancer treatment | |
| CN116113416A (zh) | 四环类衍生物、其制备方法和其医药上的用途 | |
| CN106075450A (zh) | 用于树突状细胞癌症疫苗的小分子增强剂 | |
| CN114728994A (zh) | 芳基磷氧类化合物及其用途 | |
| EP3125901B1 (en) | Derivatives of cephalosporin for treating cancer | |
| CN121001749A (zh) | 药物偶联物治疗肿瘤疾病的用途及方法 | |
| JP2026500719A (ja) | アルファ－ｖ－ベータ－８インテグリン阻害剤及びその使用 | |
| RU2004135307A (ru) | Производное эпотилона для лечения гепатомы и других раковых заболеваний | |
| AU2013292054B2 (en) | Use of VEGFR-3 inhibitors for treating hepatocellular carcinoma | |
| WO2017176565A1 (en) | Combinations of an anti-b7-h1 antibody and a cxcr4 peptide antagonist for treating a solid tumor | |
| CN110769857A (zh) | 包含靶向治疗剂的联合疗法 | |
| JP2005510471A (ja) | 減少した毒性のシスプラチン製剤及びそれを使用する方法 | |
| AU2023317788A1 (en) | Combination therapy of cdk7 inhibitors with other anti-cancer therapies |