JP2020529471A5 - - Google Patents
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- Publication number
- JP2020529471A5 JP2020529471A5 JP2020527849A JP2020527849A JP2020529471A5 JP 2020529471 A5 JP2020529471 A5 JP 2020529471A5 JP 2020527849 A JP2020527849 A JP 2020527849A JP 2020527849 A JP2020527849 A JP 2020527849A JP 2020529471 A5 JP2020529471 A5 JP 2020529471A5
- Authority
- JP
- Japan
- Prior art keywords
- hydroxy
- compound
- tran
- formula
- trans
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 claims 26
- 150000001875 compounds Chemical class 0.000 claims 10
- 230000000845 anti-microbial effect Effects 0.000 claims 9
- 238000002360 preparation method Methods 0.000 claims 7
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 6
- 244000000010 microbial pathogen Species 0.000 claims 6
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 6
- 125000001424 substituent group Chemical group 0.000 claims 6
- 241000894006 Bacteria Species 0.000 claims 3
- 239000004599 antimicrobial Substances 0.000 claims 3
- 125000001475 halogen functional group Chemical group 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- 150000003573 thiols Chemical class 0.000 claims 3
- 241000233866 Fungi Species 0.000 claims 2
- 230000003115 biocidal effect Effects 0.000 claims 2
- 238000009472 formulation Methods 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 241000588626 Acinetobacter baumannii Species 0.000 claims 1
- 241000222120 Candida <Saccharomycetales> Species 0.000 claims 1
- RJQXTJLFIWVMTO-TYNCELHUSA-N Methicillin Chemical compound COC1=CC=CC(OC)=C1C(=O)N[C@@H]1C(=O)N2[C@@H](C(O)=O)C(C)(C)S[C@@H]21 RJQXTJLFIWVMTO-TYNCELHUSA-N 0.000 claims 1
- 241000589517 Pseudomonas aeruginosa Species 0.000 claims 1
- 241000191967 Staphylococcus aureus Species 0.000 claims 1
- 239000003242 anti bacterial agent Substances 0.000 claims 1
- 244000052616 bacterial pathogen Species 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 239000012459 cleaning agent Substances 0.000 claims 1
- 238000010411 cooking Methods 0.000 claims 1
- 239000003599 detergent Substances 0.000 claims 1
- 210000001508 eye Anatomy 0.000 claims 1
- 210000004209 hair Anatomy 0.000 claims 1
- 238000011065 in-situ storage Methods 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 238000001990 intravenous administration Methods 0.000 claims 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 1
- 229960003085 meticillin Drugs 0.000 claims 1
- 210000004400 mucous membrane Anatomy 0.000 claims 1
- 210000004761 scalp Anatomy 0.000 claims 1
- 210000003491 skin Anatomy 0.000 claims 1
- 241000894007 species Species 0.000 claims 1
- 238000001356 surgical procedure Methods 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762537661P | 2017-07-27 | 2017-07-27 | |
| US62/537,661 | 2017-07-27 | ||
| US201862676676P | 2018-05-25 | 2018-05-25 | |
| US62/676,676 | 2018-05-25 | ||
| PCT/US2018/043833 WO2019023425A1 (en) | 2017-07-27 | 2018-07-26 | SUBSTITUTED TOLANES FOR THE MODULATION OF MICROBIAL COLONIZATION |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020529471A JP2020529471A (ja) | 2020-10-08 |
| JP2020529471A5 true JP2020529471A5 (https=) | 2021-09-02 |
| JP7266597B2 JP7266597B2 (ja) | 2023-04-28 |
Family
ID=65040339
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020527849A Active JP7266597B2 (ja) | 2017-07-27 | 2018-07-26 | 微生物のコロニー形成を抑制するための置換トラン |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US11351126B2 (https=) |
| EP (1) | EP3658128A4 (https=) |
| JP (1) | JP7266597B2 (https=) |
| KR (1) | KR102620652B1 (https=) |
| CN (1) | CN111526873B (https=) |
| AU (1) | AU2018306420B2 (https=) |
| BR (1) | BR112020001619A2 (https=) |
| CA (1) | CA3070427A1 (https=) |
| IL (1) | IL272188B (https=) |
| MX (1) | MX2020001043A (https=) |
| MY (1) | MY204404A (https=) |
| SG (1) | SG11202000708SA (https=) |
| WO (1) | WO2019023425A1 (https=) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11351126B2 (en) * | 2017-07-27 | 2022-06-07 | BioMendics, LLC | Substituted tolans for the modulation of microbial colonization |
| KR102407606B1 (ko) * | 2020-04-27 | 2022-06-10 | 경희대학교 산학협력단 | 송악 추출물을 포함하는 바이오필름 형성 억제용 조성물 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3840527A (en) | 1971-08-16 | 1974-10-08 | Riker Laboratories Inc | Haloalkylsulfonamido-substituted tolan and stilbene compounds |
| US5420361A (en) * | 1992-02-05 | 1995-05-30 | Bio-Technical Resources | Formulation of and dehydration of hydroxylated diphenyl acetylenes |
| US6599945B2 (en) | 2000-08-15 | 2003-07-29 | Northeastern Ohio Universities College Of Medicine | Methods for treating subjects infected with a herpes virus |
| KR101076018B1 (ko) | 2003-01-08 | 2011-10-21 | 유니버시티 오브 워싱톤 | 항균제 |
| US8530512B2 (en) * | 2004-10-18 | 2013-09-10 | Aaron P. Monte | Broad spectrum gram-positive antimicrobials and anthelmintics with efficacy against drug-resistant strains and Mycobacterium species |
| TWI519508B (zh) * | 2007-06-12 | 2016-02-01 | Achaogen Inc | 抗菌劑 |
| US8716355B2 (en) * | 2007-06-20 | 2014-05-06 | Kent State University | Hydroxylated tolans and related compounds in the treatment of a cancer |
| WO2009126700A1 (en) * | 2008-04-08 | 2009-10-15 | Kent State University | Hydroxylated tolans and related compounds as cosmetics or therapeutics for skin conditions |
| IT1399222B1 (it) | 2010-01-28 | 2013-04-11 | Pittiruti | Catetere per la somministrazione parenterale di fluidi biomedicali |
| CN101914080B (zh) * | 2010-08-05 | 2012-10-03 | 上海交通大学 | 苯并呋喃-3-甲酮取代苯基类化合物及其制备和应用 |
| EP2750625A4 (en) | 2011-08-31 | 2015-08-19 | Univ Columbia | REDUCTION OF BIOFILMS ON MEDICAL DEVICES |
| KR20170141705A (ko) * | 2015-04-08 | 2017-12-26 | 바이오멘딕스, 엘엘씨 | 상처 치유를 조절하기 위한 제형 및 방법 |
| US11351126B2 (en) * | 2017-07-27 | 2022-06-07 | BioMendics, LLC | Substituted tolans for the modulation of microbial colonization |
-
2018
- 2018-07-26 US US16/633,979 patent/US11351126B2/en active Active
- 2018-07-26 BR BR112020001619-5A patent/BR112020001619A2/pt active Search and Examination
- 2018-07-26 MX MX2020001043A patent/MX2020001043A/es unknown
- 2018-07-26 AU AU2018306420A patent/AU2018306420B2/en active Active
- 2018-07-26 KR KR1020207005214A patent/KR102620652B1/ko active Active
- 2018-07-26 EP EP18838848.2A patent/EP3658128A4/en active Pending
- 2018-07-26 CA CA3070427A patent/CA3070427A1/en active Pending
- 2018-07-26 CN CN201880055664.4A patent/CN111526873B/zh active Active
- 2018-07-26 IL IL272188A patent/IL272188B/en unknown
- 2018-07-26 MY MYPI2020000380A patent/MY204404A/en unknown
- 2018-07-26 SG SG11202000708SA patent/SG11202000708SA/en unknown
- 2018-07-26 JP JP2020527849A patent/JP7266597B2/ja active Active
- 2018-07-26 WO PCT/US2018/043833 patent/WO2019023425A1/en not_active Ceased
-
2022
- 2022-06-06 US US17/833,216 patent/US20220296538A1/en active Pending
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