JP2020529193A - ドナー特異的セルフリーｄｎａを用いる移植対象における状態の評価 - Google Patents

ドナー特異的セルフリーｄｎａを用いる移植対象における状態の評価 Download PDF

Info

Publication number
JP2020529193A
JP2020529193A JP2019571019A JP2019571019A JP2020529193A JP 2020529193 A JP2020529193 A JP 2020529193A JP 2019571019 A JP2019571019 A JP 2019571019A JP 2019571019 A JP2019571019 A JP 2019571019A JP 2020529193 A JP2020529193 A JP 2020529193A
Authority
JP
Japan
Prior art keywords
dna
subject
amount
donor
threshold
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2019571019A
Other languages
English (en)
Japanese (ja)
Other versions
JP2020529193A5 (enExample
Inventor
ミッチェル，アオイ，トミタ
ミッチェル，ミカエル
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Medical College of Wisconsin
Original Assignee
Medical College of Wisconsin
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medical College of Wisconsin filed Critical Medical College of Wisconsin
Publication of JP2020529193A publication Critical patent/JP2020529193A/ja
Publication of JP2020529193A5 publication Critical patent/JP2020529193A5/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Pathology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
JP2019571019A 2017-06-20 2018-06-20 ドナー特異的セルフリーｄｎａを用いる移植対象における状態の評価 Pending JP2020529193A (ja)

Applications Claiming Priority (27)

Application Number Priority Date Filing Date Title
US201762522556P 2017-06-20 2017-06-20
US201762522547P 2017-06-20 2017-06-20
US201762522560P 2017-06-20 2017-06-20
US62/522,547 2017-06-20
US62/522,560 2017-06-20
US62/522,556 2017-06-20
US201762542787P 2017-08-08 2017-08-08
US201762542790P 2017-08-08 2017-08-08
US62/542,790 2017-08-08
US62/542,787 2017-08-08
US201762546798P 2017-08-17 2017-08-17
US201762546848P 2017-08-17 2017-08-17
US201762546872P 2017-08-17 2017-08-17
US62/546,798 2017-08-17
US62/546,848 2017-08-17
US62/546,872 2017-08-17
US201762571715P 2017-10-12 2017-10-12
US201762571709P 2017-10-12 2017-10-12
US62/571,709 2017-10-12
US62/571,715 2017-10-12
US201762576641P 2017-10-24 2017-10-24
US62/576,641 2017-10-24
US201862632960P 2018-02-20 2018-02-20
US62/632,960 2018-02-20
US201862653261P 2018-04-05 2018-04-05
US62/653,261 2018-04-05
PCT/US2018/038604 WO2018237078A1 (en) 2017-06-20 2018-06-20 Assessing conditions in transplant subjects using donor-specific cell-free dna

Publications (2)

Publication Number Publication Date
JP2020529193A true JP2020529193A (ja) 2020-10-08
JP2020529193A5 JP2020529193A5 (enExample) 2021-07-29

Family

ID=63047415

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2019571019A Pending JP2020529193A (ja) 2017-06-20 2018-06-20 ドナー特異的セルフリーｄｎａを用いる移植対象における状態の評価

Country Status (8)

Country Link
US (1) US20210139988A1 (enExample)
EP (1) EP3642367A1 (enExample)
JP (1) JP2020529193A (enExample)
CN (1) CN111094593A (enExample)
AU (1) AU2018288835A1 (enExample)
CA (1) CA3067634A1 (enExample)
IL (1) IL271458A (enExample)
WO (1) WO2018237078A1 (enExample)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9424392B2 (en) 2005-11-26 2016-08-23 Natera, Inc. System and method for cleaning noisy genetic data from target individuals using genetic data from genetically related individuals
US12221653B2 (en) 2010-05-18 2025-02-11 Natera, Inc. Methods for simultaneous amplification of target loci
US11332793B2 (en) 2010-05-18 2022-05-17 Natera, Inc. Methods for simultaneous amplification of target loci
US11332785B2 (en) 2010-05-18 2022-05-17 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US9677118B2 (en) 2014-04-21 2017-06-13 Natera, Inc. Methods for simultaneous amplification of target loci
US11339429B2 (en) 2010-05-18 2022-05-24 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US10316362B2 (en) 2010-05-18 2019-06-11 Natera, Inc. Methods for simultaneous amplification of target loci
US11408031B2 (en) 2010-05-18 2022-08-09 Natera, Inc. Methods for non-invasive prenatal paternity testing
US12152275B2 (en) 2010-05-18 2024-11-26 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US11939634B2 (en) 2010-05-18 2024-03-26 Natera, Inc. Methods for simultaneous amplification of target loci
US20190010543A1 (en) 2010-05-18 2019-01-10 Natera, Inc. Methods for simultaneous amplification of target loci
CA3207599A1 (en) 2010-05-18 2011-11-24 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US11322224B2 (en) 2010-05-18 2022-05-03 Natera, Inc. Methods for non-invasive prenatal ploidy calling
BR112013020220B1 (pt) 2011-02-09 2020-03-17 Natera, Inc. Método para determinar o estado de ploidia de um cromossomo em um feto em gestação
US20140100126A1 (en) 2012-08-17 2014-04-10 Natera, Inc. Method for Non-Invasive Prenatal Testing Using Parental Mosaicism Data
EP3134541B1 (en) 2014-04-21 2020-08-19 Natera, Inc. Detecting copy number variations (cnv) of chromosomal segments in cancer
US20180173846A1 (en) 2014-06-05 2018-06-21 Natera, Inc. Systems and Methods for Detection of Aneuploidy
US11479812B2 (en) 2015-05-11 2022-10-25 Natera, Inc. Methods and compositions for determining ploidy
RU2760913C2 (ru) 2016-04-15 2021-12-01 Натера, Инк. Способы выявления рака легкого
WO2018067517A1 (en) 2016-10-04 2018-04-12 Natera, Inc. Methods for characterizing copy number variation using proximity-litigation sequencing
GB201618485D0 (en) 2016-11-02 2016-12-14 Ucl Business Plc Method of detecting tumour recurrence
US10011870B2 (en) 2016-12-07 2018-07-03 Natera, Inc. Compositions and methods for identifying nucleic acid molecules
CA3067637A1 (en) 2017-06-20 2018-12-27 The Medical College Of Wisconsin, Inc. Assessing transplant complication risk with total cell-free dna
US12084720B2 (en) 2017-12-14 2024-09-10 Natera, Inc. Assessing graft suitability for transplantation
US12024738B2 (en) 2018-04-14 2024-07-02 Natera, Inc. Methods for cancer detection and monitoring
US12234509B2 (en) 2018-07-03 2025-02-25 Natera, Inc. Methods for detection of donor-derived cell-free DNA
WO2020206292A2 (en) * 2019-04-03 2020-10-08 The Medical College Of Wisconsin, Inc. Assessing conditions in transplant subjects using donor-specific cell-free dna
US11931674B2 (en) 2019-04-04 2024-03-19 Natera, Inc. Materials and methods for processing blood samples
WO2020247263A1 (en) 2019-06-06 2020-12-10 Natera, Inc. Methods for detecting immune cell dna and monitoring immune system

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013509883A (ja) * 2009-11-06 2013-03-21 ザ ボード オブ トラスティーズ オブ ザ リーランド スタンフォード ジュニア ユニバーシティ 臓器移植患者における移植片拒絶反応の非侵襲的診断方法
WO2013159035A2 (en) * 2012-04-19 2013-10-24 Medical College Of Wisconsin, Inc. Highly sensitive surveillance using detection of cell free dna
WO2015035177A1 (en) * 2013-09-06 2015-03-12 Immucor Gti Diagnostics, Inc. Compositions and methods for diagnosis and prediction of solid organ graft rejection
WO2015069933A1 (en) * 2013-11-06 2015-05-14 The Board Of Trustees Of The Leland Stanford Junior University Circulating cell-free dna for diagnosis of transplant rejection
WO2016176662A1 (en) * 2015-04-30 2016-11-03 Medical College Of Wisconsin, Inc. Multiplexed optimized mismatch amplification (moma)-real time pcr for assessing cell-free dna

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20160258010A1 (en) * 2013-10-18 2016-09-08 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Allele specific pcr assay for detection of nucleotide variants
WO2016123698A1 (en) * 2015-02-06 2016-08-11 Uti Limited Partnership Diagnostic assay for post-transplant assessment of potential rejection of donor organs

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013509883A (ja) * 2009-11-06 2013-03-21 ザ ボード オブ トラスティーズ オブ ザ リーランド スタンフォード ジュニア ユニバーシティ 臓器移植患者における移植片拒絶反応の非侵襲的診断方法
WO2013159035A2 (en) * 2012-04-19 2013-10-24 Medical College Of Wisconsin, Inc. Highly sensitive surveillance using detection of cell free dna
WO2015035177A1 (en) * 2013-09-06 2015-03-12 Immucor Gti Diagnostics, Inc. Compositions and methods for diagnosis and prediction of solid organ graft rejection
WO2015069933A1 (en) * 2013-11-06 2015-05-14 The Board Of Trustees Of The Leland Stanford Junior University Circulating cell-free dna for diagnosis of transplant rejection
WO2016176662A1 (en) * 2015-04-30 2016-11-03 Medical College Of Wisconsin, Inc. Multiplexed optimized mismatch amplification (moma)-real time pcr for assessing cell-free dna

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
CHEN, J.J., ET AL.: ""Non-invasive prenatal diagnosis using fetal DNA in maternal plasma: a preliminary study for identif", BMJ OPEN, vol. 5, no. 7, JPN6023003393, 22 July 2015 (2015-07-22), pages 007648 - 8, ISSN: 0005162124 *
HIDESTRAND, M., ET AL.: ""Highly Sensitive Non-Invasive Cardiac Transplant Rejection Monitoring Using Targeted Quantification", J AM COLL CARDIOL, vol. 63, no. 12, JPN6022013263, 2014, pages 1224 - 1226, ISSN: 0005162123 *

Also Published As

Publication number Publication date
IL271458A (en) 2020-01-30
CN111094593A (zh) 2020-05-01
CA3067634A1 (en) 2018-12-27
WO2018237078A1 (en) 2018-12-27
EP3642367A1 (en) 2020-04-29
AU2018288835A1 (en) 2020-01-16
US20210139988A1 (en) 2021-05-13

Similar Documents

Publication Publication Date Title
JP7323462B2 (ja) セルフリーｄｎａによる移植患者のモニタリング
JP2020529193A (ja) ドナー特異的セルフリーｄｎａを用いる移植対象における状態の評価
US20220356522A1 (en) Assessing conditions in transplant subjects using donor-specific cell-free dna
EP3642353B1 (en) Assessing transplant complication risk with total cell-free dna
EP3449019B1 (en) Multiplexed optimized mismatch amplification (moma)-target number
US20220267849A1 (en) Transplant patient monitoring with cell-free dna
US20230167499A1 (en) Methods for assessing risk using total cell-free dna
JP2022002508A (ja) 無細胞ｄｎａを評価するための多重／最適化ミスマッチ増幅（ｍｏｍａ）−リアルタイムｐｃｒ
CN110177874A (zh) 用于使用错配扩增和统计方法来评估风险的方法
HK40029115A (en) Assessing transplant complication risk with total cell-free dna
HK40029115B (en) Assessing transplant complication risk with total cell-free dna
HK40005635A (en) Multiplexed optimized mismatch amplification (moma)-target number
HK40005635B (en) Multiplexed optimized mismatch amplification (moma)-target number

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20210617

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20210617

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20220323

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20220405

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20220630

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20220905

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20221005

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20230130

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20230427

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20230622

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20230928