CA3067634A1 - Assessing conditions in transplant subjects using donor-specific cell-free dna - Google Patents

Assessing conditions in transplant subjects using donor-specific cell-free dna Download PDF

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Publication number
CA3067634A1
CA3067634A1 CA3067634A CA3067634A CA3067634A1 CA 3067634 A1 CA3067634 A1 CA 3067634A1 CA 3067634 A CA3067634 A CA 3067634A CA 3067634 A CA3067634 A CA 3067634A CA 3067634 A1 CA3067634 A1 CA 3067634A1
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CA
Canada
Prior art keywords
dna
subject
amount
donor
threshold
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3067634A
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English (en)
French (fr)
Inventor
Aoy Tomita Mitchell
Michael Mitchell
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Medical College of Wisconsin
Original Assignee
Medical College of Wisconsin
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Publication date
Application filed by Medical College of Wisconsin filed Critical Medical College of Wisconsin
Publication of CA3067634A1 publication Critical patent/CA3067634A1/en
Pending legal-status Critical Current

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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/156Polymorphic or mutational markers
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/158Expression markers

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Pathology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
CA3067634A 2017-06-20 2018-06-20 Assessing conditions in transplant subjects using donor-specific cell-free dna Pending CA3067634A1 (en)

Applications Claiming Priority (27)

Application Number Priority Date Filing Date Title
US201762522556P 2017-06-20 2017-06-20
US201762522547P 2017-06-20 2017-06-20
US201762522560P 2017-06-20 2017-06-20
US62/522,547 2017-06-20
US62/522,560 2017-06-20
US62/522,556 2017-06-20
US201762542787P 2017-08-08 2017-08-08
US201762542790P 2017-08-08 2017-08-08
US62/542,790 2017-08-08
US62/542,787 2017-08-08
US201762546798P 2017-08-17 2017-08-17
US201762546848P 2017-08-17 2017-08-17
US201762546872P 2017-08-17 2017-08-17
US62/546,798 2017-08-17
US62/546,848 2017-08-17
US62/546,872 2017-08-17
US201762571715P 2017-10-12 2017-10-12
US201762571709P 2017-10-12 2017-10-12
US62/571,709 2017-10-12
US62/571,715 2017-10-12
US201762576641P 2017-10-24 2017-10-24
US62/576,641 2017-10-24
US201862632960P 2018-02-20 2018-02-20
US62/632,960 2018-02-20
US201862653261P 2018-04-05 2018-04-05
US62/653,261 2018-04-05
PCT/US2018/038604 WO2018237078A1 (en) 2017-06-20 2018-06-20 Assessing conditions in transplant subjects using donor-specific cell-free dna

Publications (1)

Publication Number Publication Date
CA3067634A1 true CA3067634A1 (en) 2018-12-27

Family

ID=63047415

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3067634A Pending CA3067634A1 (en) 2017-06-20 2018-06-20 Assessing conditions in transplant subjects using donor-specific cell-free dna

Country Status (8)

Country Link
US (1) US20210139988A1 (enExample)
EP (1) EP3642367A1 (enExample)
JP (1) JP2020529193A (enExample)
CN (1) CN111094593A (enExample)
AU (1) AU2018288835A1 (enExample)
CA (1) CA3067634A1 (enExample)
IL (1) IL271458A (enExample)
WO (1) WO2018237078A1 (enExample)

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US9424392B2 (en) 2005-11-26 2016-08-23 Natera, Inc. System and method for cleaning noisy genetic data from target individuals using genetic data from genetically related individuals
US12221653B2 (en) 2010-05-18 2025-02-11 Natera, Inc. Methods for simultaneous amplification of target loci
US11332793B2 (en) 2010-05-18 2022-05-17 Natera, Inc. Methods for simultaneous amplification of target loci
US11332785B2 (en) 2010-05-18 2022-05-17 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US9677118B2 (en) 2014-04-21 2017-06-13 Natera, Inc. Methods for simultaneous amplification of target loci
US11339429B2 (en) 2010-05-18 2022-05-24 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US10316362B2 (en) 2010-05-18 2019-06-11 Natera, Inc. Methods for simultaneous amplification of target loci
US11408031B2 (en) 2010-05-18 2022-08-09 Natera, Inc. Methods for non-invasive prenatal paternity testing
US12152275B2 (en) 2010-05-18 2024-11-26 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US11939634B2 (en) 2010-05-18 2024-03-26 Natera, Inc. Methods for simultaneous amplification of target loci
US20190010543A1 (en) 2010-05-18 2019-01-10 Natera, Inc. Methods for simultaneous amplification of target loci
CA3207599A1 (en) 2010-05-18 2011-11-24 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US11322224B2 (en) 2010-05-18 2022-05-03 Natera, Inc. Methods for non-invasive prenatal ploidy calling
BR112013020220B1 (pt) 2011-02-09 2020-03-17 Natera, Inc. Método para determinar o estado de ploidia de um cromossomo em um feto em gestação
US20140100126A1 (en) 2012-08-17 2014-04-10 Natera, Inc. Method for Non-Invasive Prenatal Testing Using Parental Mosaicism Data
EP3134541B1 (en) 2014-04-21 2020-08-19 Natera, Inc. Detecting copy number variations (cnv) of chromosomal segments in cancer
US20180173846A1 (en) 2014-06-05 2018-06-21 Natera, Inc. Systems and Methods for Detection of Aneuploidy
US11479812B2 (en) 2015-05-11 2022-10-25 Natera, Inc. Methods and compositions for determining ploidy
RU2760913C2 (ru) 2016-04-15 2021-12-01 Натера, Инк. Способы выявления рака легкого
WO2018067517A1 (en) 2016-10-04 2018-04-12 Natera, Inc. Methods for characterizing copy number variation using proximity-litigation sequencing
GB201618485D0 (en) 2016-11-02 2016-12-14 Ucl Business Plc Method of detecting tumour recurrence
US10011870B2 (en) 2016-12-07 2018-07-03 Natera, Inc. Compositions and methods for identifying nucleic acid molecules
CA3067637A1 (en) 2017-06-20 2018-12-27 The Medical College Of Wisconsin, Inc. Assessing transplant complication risk with total cell-free dna
US12084720B2 (en) 2017-12-14 2024-09-10 Natera, Inc. Assessing graft suitability for transplantation
US12024738B2 (en) 2018-04-14 2024-07-02 Natera, Inc. Methods for cancer detection and monitoring
US12234509B2 (en) 2018-07-03 2025-02-25 Natera, Inc. Methods for detection of donor-derived cell-free DNA
WO2020206292A2 (en) * 2019-04-03 2020-10-08 The Medical College Of Wisconsin, Inc. Assessing conditions in transplant subjects using donor-specific cell-free dna
US11931674B2 (en) 2019-04-04 2024-03-19 Natera, Inc. Materials and methods for processing blood samples
WO2020247263A1 (en) 2019-06-06 2020-12-10 Natera, Inc. Methods for detecting immune cell dna and monitoring immune system

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013509883A (ja) * 2009-11-06 2013-03-21 ザ ボード オブ トラスティーズ オブ ザ リーランド スタンフォード ジュニア ユニバーシティ 臓器移植患者における移植片拒絶反応の非侵襲的診断方法
WO2013159035A2 (en) * 2012-04-19 2013-10-24 Medical College Of Wisconsin, Inc. Highly sensitive surveillance using detection of cell free dna
US20160376652A1 (en) * 2013-09-06 2016-12-29 Immucor Gti Diagnostics, Inc. Compositions and methods for diagnosis and prediction of solid organ graft rejection
US20160258010A1 (en) * 2013-10-18 2016-09-08 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Allele specific pcr assay for detection of nucleotide variants
WO2015069933A1 (en) * 2013-11-06 2015-05-14 The Board Of Trustees Of The Leland Stanford Junior University Circulating cell-free dna for diagnosis of transplant rejection
WO2016123698A1 (en) * 2015-02-06 2016-08-11 Uti Limited Partnership Diagnostic assay for post-transplant assessment of potential rejection of donor organs
HK1252152A1 (zh) * 2015-04-30 2019-05-17 Medical College Of Wisconsin, Inc. 用於評估無細胞dna的多重優化錯配擴增(moma)實時pcr

Also Published As

Publication number Publication date
IL271458A (en) 2020-01-30
CN111094593A (zh) 2020-05-01
WO2018237078A1 (en) 2018-12-27
EP3642367A1 (en) 2020-04-29
JP2020529193A (ja) 2020-10-08
AU2018288835A1 (en) 2020-01-16
US20210139988A1 (en) 2021-05-13

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