JP2020528910A5 - - Google Patents

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Publication number
JP2020528910A5
JP2020528910A5 JP2020504133A JP2020504133A JP2020528910A5 JP 2020528910 A5 JP2020528910 A5 JP 2020528910A5 JP 2020504133 A JP2020504133 A JP 2020504133A JP 2020504133 A JP2020504133 A JP 2020504133A JP 2020528910 A5 JP2020528910 A5 JP 2020528910A5
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JP
Japan
Prior art keywords
oligonucleotide
aspects
composition according
tablets
series
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2020504133A
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English (en)
Japanese (ja)
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JP2020528910A (ja
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Publication date
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Priority claimed from PCT/US2018/043867 external-priority patent/WO2019023439A1/en
Publication of JP2020528910A publication Critical patent/JP2020528910A/ja
Publication of JP2020528910A5 publication Critical patent/JP2020528910A5/ja
Pending legal-status Critical Current

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JP2020504133A 2017-07-28 2018-07-26 オリゴヌクレオチド化合物の調製方法 Pending JP2020528910A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762538504P 2017-07-28 2017-07-28
US62/538,504 2017-07-28
PCT/US2018/043867 WO2019023439A1 (en) 2017-07-28 2018-07-26 PROCESS FOR THE PREPARATION OF OLIGONUCLEOTIDE COMPOUNDS

Publications (2)

Publication Number Publication Date
JP2020528910A JP2020528910A (ja) 2020-10-01
JP2020528910A5 true JP2020528910A5 (https=) 2021-09-09

Family

ID=65041406

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2020504133A Pending JP2020528910A (ja) 2017-07-28 2018-07-26 オリゴヌクレオチド化合物の調製方法

Country Status (6)

Country Link
US (1) US20200392491A1 (https=)
EP (1) EP3658155A4 (https=)
JP (1) JP2020528910A (https=)
KR (1) KR20200042902A (https=)
CN (1) CN111148519A (https=)
WO (1) WO2019023439A1 (https=)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2019505598A (ja) 2016-02-23 2019-02-28 セルジーン アルパイン インベストメント カンパニー Ii, エルエルシー Smad7の阻害を用いて、腸線維症を治療する方法
CN113474633A (zh) * 2019-02-26 2021-10-01 罗氏创新中心哥本哈根有限公司 寡核苷酸配制方法
AU2020309307B2 (en) * 2019-07-09 2023-03-30 F. Hoffmann-La Roche Ag Process for the deprotection of oligonucleotides
CN110468171B (zh) * 2019-09-20 2021-10-29 凯莱英医药集团(天津)股份有限公司 核酸的合成方法
WO2021168306A1 (en) * 2020-02-21 2021-08-26 Biogen Ma Inc. Methods of preparing oligonucleotide compositions using ultrafiltration / diafiltration
WO2024138152A1 (en) * 2022-12-23 2024-06-27 Asahi Kasei Bioprocess America, Inc. System for performing cleavage, deprotection, ultrafiltration, and diafiltration operations
CN117143165B (zh) * 2023-08-30 2026-02-03 上海奥锐特生物科技有限公司 一种寡核苷酸的纯化方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007050789A2 (en) * 2005-10-25 2007-05-03 Nëdken Corporation Glycosyl-oligonucleotide conjugates and methods
WO2014120861A2 (en) * 2013-01-31 2014-08-07 Isis Pharmaceuticals, Inc. Method of preparing oligomeric compounds using modified coupling protocols
AU2015257589A1 (en) * 2014-05-09 2016-11-24 Nogra Pharma Limited Methods for treating inflammatory bowel disease
WO2015011694A2 (en) * 2014-10-17 2015-01-29 Celgene Corporation Isotopologues of smad7 antisense oligonucleotides
EP3355896A2 (en) * 2015-09-30 2018-08-08 Nogra Pharma Limited Methods of using smad7 antisense oligonucleotides based on biomarker expression

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