JP2020528910A - オリゴヌクレオチド化合物の調製方法 - Google Patents

オリゴヌクレオチド化合物の調製方法 Download PDF

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JP2020528910A
JP2020528910A JP2020504133A JP2020504133A JP2020528910A JP 2020528910 A JP2020528910 A JP 2020528910A JP 2020504133 A JP2020504133 A JP 2020504133A JP 2020504133 A JP2020504133 A JP 2020504133A JP 2020528910 A JP2020528910 A JP 2020528910A
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mmol
oligonucleotide
certain embodiments
composition according
oligonucleotides
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JP2020528910A5 (enExample
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フランク アンソニー
フランク アンソニー
クロップフェル ケビン
クロップフェル ケビン
ジョセフ ジュニア．ギャラガー ドナルド
ジョセフ ジュニア．ギャラガー ドナルド
ジャファルポウル ラレフ
ジャファルポウル ラレフ
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Celgene Corp
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Celgene Corp
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    • C—CHEMISTRY; METALLURGY
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    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
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    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C—CHEMISTRY; METALLURGY
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/315—Phosphorothioates
    • C—CHEMISTRY; METALLURGY
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/33—Chemical structure of the base
    • C12N2310/334—Modified C
    • C12N2310/3341—5-Methylcytosine
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    • C12N2330/00—Production
    • C12N2330/30—Production chemically synthesised

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  • Health & Medical Sciences (AREA)
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  • Engineering & Computer Science (AREA)
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  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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JP2020504133A 2017-07-28 2018-07-26 オリゴヌクレオチド化合物の調製方法 Pending JP2020528910A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762538504P 2017-07-28 2017-07-28
US62/538,504 2017-07-28
PCT/US2018/043867 WO2019023439A1 (en) 2017-07-28 2018-07-26 PROCESS FOR THE PREPARATION OF OLIGONUCLEOTIDE COMPOUNDS

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JP2020528910A true JP2020528910A (ja) 2020-10-01
JP2020528910A5 JP2020528910A5 (enExample) 2021-09-09

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JP2020504133A Pending JP2020528910A (ja) 2017-07-28 2018-07-26 オリゴヌクレオチド化合物の調製方法

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US (1) US20200392491A1 (enExample)
EP (1) EP3658155A4 (enExample)
JP (1) JP2020528910A (enExample)
KR (1) KR20200042902A (enExample)
CN (1) CN111148519A (enExample)
WO (1) WO2019023439A1 (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2019505598A (ja) 2016-02-23 2019-02-28 セルジーン アルパイン インベストメント カンパニー Ｉｉ， エルエルシー Ｓｍａｄ７の阻害を用いて、腸線維症を治療する方法
WO2020173845A1 (en) * 2019-02-26 2020-09-03 Roche Innovation Center Copenhagen A/S Oligonucleotide formulation method
JP7311642B2 (ja) * 2019-07-09 2023-07-19 エフ． ホフマン－ラ ロシュ アーゲー オリゴヌクレオチドを脱保護するための方法
CN110468171B (zh) * 2019-09-20 2021-10-29 凯莱英医药集团（天津）股份有限公司 核酸的合成方法
KR20220156843A (ko) * 2020-02-21 2022-11-28 바이오젠 엠에이 인코포레이티드 한외여과 / 정용여과를 사용한 올리고뉴클레오티드 조성물의 제조 방법
WO2024138152A1 (en) * 2022-12-23 2024-06-27 Asahi Kasei Bioprocess America, Inc. System for performing cleavage, deprotection, ultrafiltration, and diafiltration operations
CN117143165A (zh) * 2023-08-30 2023-12-01 上海奥锐特生物科技有限公司 一种寡核苷酸的纯化方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007050789A2 (en) * 2005-10-25 2007-05-03 Nëdken Corporation Glycosyl-oligonucleotide conjugates and methods
US9701708B2 (en) * 2013-01-31 2017-07-11 Ionis Pharmaceuticals, Inc. Method of preparing oligomeric compounds using modified coupling protocols
KR20170005058A (ko) * 2014-05-09 2017-01-11 노그라 파마 리미티드 염증성 장 질환을 치료하는 방법
JP2017532982A (ja) * 2014-10-17 2017-11-09 セルジーン アルパイン インベストメント カンパニー Ｉｉ， エルエルシー Ｓｍａｄ７アンチセンスオリゴヌクレオチドの同位体置換体
EP3355896A2 (en) * 2015-09-30 2018-08-08 Nogra Pharma Limited Methods of using smad7 antisense oligonucleotides based on biomarker expression

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EP3658155A4 (en) 2021-06-30
US20200392491A1 (en) 2020-12-17
WO2019023439A1 (en) 2019-01-31
KR20200042902A (ko) 2020-04-24
CN111148519A (zh) 2020-05-12
EP3658155A1 (en) 2020-06-03

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