JP2020528903A5 - - Google Patents
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- Publication number
- JP2020528903A5 JP2020528903A5 JP2020503928A JP2020503928A JP2020528903A5 JP 2020528903 A5 JP2020528903 A5 JP 2020528903A5 JP 2020503928 A JP2020503928 A JP 2020503928A JP 2020503928 A JP2020503928 A JP 2020503928A JP 2020528903 A5 JP2020528903 A5 JP 2020528903A5
- Authority
- JP
- Japan
- Prior art keywords
- subject
- composition according
- minutes
- tpo mimetic
- cancer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 102000036693 Thrombopoietin Human genes 0.000 claims description 24
- 108010041111 Thrombopoietin Proteins 0.000 claims description 24
- 238000001959 radiotherapy Methods 0.000 claims description 18
- 230000005855 radiation Effects 0.000 claims description 10
- 230000002792 vascular Effects 0.000 claims description 6
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims description 4
- 206010028980 Neoplasm Diseases 0.000 claims description 4
- 201000011510 cancer Diseases 0.000 claims description 4
- 206010006187 Breast cancer Diseases 0.000 claims description 2
- 208000026310 Breast neoplasm Diseases 0.000 claims description 2
- 206010009944 Colon cancer Diseases 0.000 claims description 2
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims description 2
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims description 2
- 206010060862 Prostate cancer Diseases 0.000 claims description 2
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims description 2
- 206010047139 Vasoconstriction Diseases 0.000 claims description 2
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 2
- 208000029742 colonic neoplasm Diseases 0.000 claims description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 2
- 208000035475 disorder Diseases 0.000 claims description 2
- 230000003511 endothelial effect Effects 0.000 claims description 2
- 150000002148 esters Chemical class 0.000 claims description 2
- 201000010536 head and neck cancer Diseases 0.000 claims description 2
- 208000014829 head and neck neoplasm Diseases 0.000 claims description 2
- 206010073071 hepatocellular carcinoma Diseases 0.000 claims description 2
- 231100000844 hepatocellular carcinoma Toxicity 0.000 claims description 2
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 claims description 2
- 230000003993 interaction Effects 0.000 claims description 2
- 210000000265 leukocyte Anatomy 0.000 claims description 2
- 201000005202 lung cancer Diseases 0.000 claims description 2
- 208000020816 lung neoplasm Diseases 0.000 claims description 2
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims description 2
- 201000001441 melanoma Diseases 0.000 claims description 2
- 201000002528 pancreatic cancer Diseases 0.000 claims description 2
- 208000008443 pancreatic carcinoma Diseases 0.000 claims description 2
- 150000003839 salts Chemical class 0.000 claims description 2
- 238000002942 systemic radioisotope therapy Methods 0.000 claims description 2
- 230000025033 vasoconstriction Effects 0.000 claims description 2
- 230000000304 vasodilatating effect Effects 0.000 claims description 2
- 238000000034 method Methods 0.000 description 15
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762537049P | 2017-07-26 | 2017-07-26 | |
| US62/537,049 | 2017-07-26 | ||
| PCT/US2018/043821 WO2019023418A1 (en) | 2017-07-26 | 2018-07-26 | METHODS FOR PROTECTING VASCULAR INTEGRITY INDUCED BY TARGETED RADIOTHERAPY |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020528903A JP2020528903A (ja) | 2020-10-01 |
| JP2020528903A5 true JP2020528903A5 (cg-RX-API-DMAC7.html) | 2021-08-19 |
| JP7481252B2 JP7481252B2 (ja) | 2024-05-10 |
Family
ID=63165522
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020503928A Active JP7481252B2 (ja) | 2017-07-26 | 2018-07-26 | 標的放射線治療誘発性血管完全性を保護する方法 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US12251424B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP3658191A1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP7481252B2 (cg-RX-API-DMAC7.html) |
| KR (1) | KR102688415B1 (cg-RX-API-DMAC7.html) |
| CN (1) | CN111432845B (cg-RX-API-DMAC7.html) |
| AU (1) | AU2018306329B8 (cg-RX-API-DMAC7.html) |
| BR (1) | BR112020001367A2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA3070442A1 (cg-RX-API-DMAC7.html) |
| IL (1) | IL272213A (cg-RX-API-DMAC7.html) |
| PH (1) | PH12020500166A1 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2019023418A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3914272B1 (en) * | 2019-01-25 | 2024-03-06 | Janssen Pharmaceutica NV | Thrombopoietin mimetics for mitigating liver injury and promoting liver hypertrophy, regeneration and cell engraftment in conjunction with radiation and/or radiomimetic treatments |
| CN113402614A (zh) * | 2021-04-22 | 2021-09-17 | 山东泉港药业有限公司 | 血小板生成素拟肽融合蛋白(fc-tmp)编码基因与应用 |
| CN119654158A (zh) * | 2022-05-20 | 2025-03-18 | 詹森药业有限公司 | 用于减轻与暴露于辐射和/或辐射或拟辐射治疗相关的肺损伤的方法 |
| WO2024095178A1 (en) | 2022-11-01 | 2024-05-10 | Janssen Pharmaceutica Nv | Thrombopoietin mimetic for use in the treatment of acute liver failure |
| WO2025002113A1 (zh) * | 2023-06-26 | 2025-01-02 | 上海济煜医药科技有限公司 | 一种人血小板生成素受体激动剂的融合蛋白 |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT644771E (pt) | 1992-06-11 | 2002-12-31 | Alkermes Inc | Sistema de entrega da droga eritropoietina |
| US5354934A (en) | 1993-02-04 | 1994-10-11 | Amgen Inc. | Pulmonary administration of erythropoietin |
| US5869451A (en) | 1995-06-07 | 1999-02-09 | Glaxo Group Limited | Peptides and compounds that bind to a receptor |
| EP1961760A3 (en) * | 1995-06-07 | 2008-09-03 | Glaxo Group Limited | Peptides and compounds that bind to a thrombopoietin receptor |
| US7091311B2 (en) | 1996-06-07 | 2006-08-15 | Smithkline Beecham Corporation | Peptides and compounds that bind to a receptor |
| US6660843B1 (en) | 1998-10-23 | 2003-12-09 | Amgen Inc. | Modified peptides as therapeutic agents |
| NZ566812A (en) | 2002-09-18 | 2009-07-31 | Ortho Mcneil Pharm Inc | Methods of increasing platelet and hematopoietic stem cell production |
| EA009286B1 (ru) * | 2003-08-28 | 2007-12-28 | Орто-Макнейл Фармасьютикал, Инк. | Пептиды и соединения, которые связываются с рецептором |
| US7723295B2 (en) | 2003-08-28 | 2010-05-25 | Ortho-Mcneil Pharmaceutical, Inc. | Peptides and compounds that bind to a receptor |
| US20060210542A1 (en) | 2004-08-16 | 2006-09-21 | Yurkow Edward J | Use of TPO mimetic compounds and pharmaceutical compositions in the treatment of anemia |
| US7615533B2 (en) | 2004-08-16 | 2009-11-10 | Janssen Pharmaceutica N.V. | TPO peptide compounds for treatment of anemia |
| WO2007087428A2 (en) | 2006-01-25 | 2007-08-02 | Amgen Inc. | Thrombopoietic compounds |
| CA2642389C (en) | 2006-02-14 | 2014-05-06 | Janssen Pharmaceutica N.V. | Use of tpo peptide compounds and pharmaceutical compositions in the treatment of anemia |
| CN100391474C (zh) * | 2006-06-13 | 2008-06-04 | 卢建军 | 用于治疗血小板减少的注射用药物 |
| US7786159B2 (en) | 2006-12-01 | 2010-08-31 | Stategics, Inc. | Thrombopoietin mimetics |
| US8383124B2 (en) | 2008-03-12 | 2013-02-26 | Children's Hospital Medical Center | Mobilization of hematopoietic stem cells |
| KR20110015448A (ko) | 2008-06-03 | 2011-02-15 | 얀센 파마슈티카 엔.브이. | 암 치료와 관련된 혈액 질환을 예방하기 위한 ｔｐｏ 모방 펩티드 |
| KR20110122846A (ko) | 2009-02-24 | 2011-11-11 | 알렉시온 파마슈티칼스, 인코포레이티드 | 치료용 ｔｐｏ/ｅｐｏ 모방 펩티드를 포함하는 항체 |
| JP2012250880A (ja) | 2011-06-03 | 2012-12-20 | Semiconductor Energy Lab Co Ltd | グラフェン、蓄電装置および電気機器 |
| US20140047572A1 (en) | 2012-08-13 | 2014-02-13 | University Of Rochester | Thrombopoietin mimetics for the treatment of radiation or chemical induced bone marrow injury |
| US20140051631A1 (en) | 2012-08-17 | 2014-02-20 | Francoise Porteu | Pharmaceutical composition comprising tpo or an agonist of the tpo receptor |
| JP6150374B2 (ja) * | 2012-11-15 | 2017-06-21 | 国立大学法人弘前大学 | 放射線被ばく治療剤及び放射線被ばく治療方法 |
| EP3914272B1 (en) | 2019-01-25 | 2024-03-06 | Janssen Pharmaceutica NV | Thrombopoietin mimetics for mitigating liver injury and promoting liver hypertrophy, regeneration and cell engraftment in conjunction with radiation and/or radiomimetic treatments |
| US20200237872A1 (en) | 2019-01-25 | 2020-07-30 | Janssen Pharmaceutica Nv | Methods of enhancing protection against organ and vascular injury, hematopoietic recovery and survival in response to total body radiation/chemical exposure |
-
2018
- 2018-07-26 US US16/633,854 patent/US12251424B2/en active Active
- 2018-07-26 WO PCT/US2018/043821 patent/WO2019023418A1/en not_active Ceased
- 2018-07-26 BR BR112020001367-6A patent/BR112020001367A2/pt unknown
- 2018-07-26 EP EP18752969.8A patent/EP3658191A1/en not_active Withdrawn
- 2018-07-26 JP JP2020503928A patent/JP7481252B2/ja active Active
- 2018-07-26 CA CA3070442A patent/CA3070442A1/en active Pending
- 2018-07-26 CN CN201880062272.0A patent/CN111432845B/zh active Active
- 2018-07-26 KR KR1020207005448A patent/KR102688415B1/ko active Active
- 2018-07-26 AU AU2018306329A patent/AU2018306329B8/en active Active
-
2020
- 2020-01-23 PH PH12020500166A patent/PH12020500166A1/en unknown
- 2020-01-23 IL IL272213A patent/IL272213A/en unknown