JP2020528765A5 - - Google Patents
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- JP2020528765A5 JP2020528765A5 JP2020526685A JP2020526685A JP2020528765A5 JP 2020528765 A5 JP2020528765 A5 JP 2020528765A5 JP 2020526685 A JP2020526685 A JP 2020526685A JP 2020526685 A JP2020526685 A JP 2020526685A JP 2020528765 A5 JP2020528765 A5 JP 2020528765A5
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- JP
- Japan
- Prior art keywords
- seq
- nos
- antibody molecule
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- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Links
- 230000003308 immunostimulating effect Effects 0.000 claims 36
- 238000000034 method Methods 0.000 claims 31
- 206010028980 Neoplasm Diseases 0.000 claims 24
- 201000011510 cancer Diseases 0.000 claims 10
- 206010041823 squamous cell carcinoma Diseases 0.000 claims 10
- 239000008194 pharmaceutical composition Substances 0.000 claims 9
- 229940045513 CTLA4 antagonist Drugs 0.000 claims 8
- 206010033128 Ovarian cancer Diseases 0.000 claims 6
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 6
- 201000009030 Carcinoma Diseases 0.000 claims 5
- 206010025323 Lymphomas Diseases 0.000 claims 5
- 206010029260 Neuroblastoma Diseases 0.000 claims 5
- 206010039491 Sarcoma Diseases 0.000 claims 5
- 208000008732 thymoma Diseases 0.000 claims 5
- 108010021064 CTLA-4 Antigen Proteins 0.000 claims 4
- 102100039498 Cytotoxic T-lymphocyte protein 4 Human genes 0.000 claims 4
- 108010021472 Fc gamma receptor IIB Proteins 0.000 claims 4
- 101001057504 Homo sapiens Interferon-stimulated gene 20 kDa protein Proteins 0.000 claims 4
- 101001055144 Homo sapiens Interleukin-2 receptor subunit alpha Proteins 0.000 claims 4
- 101000801234 Homo sapiens Tumor necrosis factor receptor superfamily member 18 Proteins 0.000 claims 4
- 101000851370 Homo sapiens Tumor necrosis factor receptor superfamily member 9 Proteins 0.000 claims 4
- 108010073807 IgG Receptors Proteins 0.000 claims 4
- 102000009490 IgG Receptors Human genes 0.000 claims 4
- 102100026878 Interleukin-2 receptor subunit alpha Human genes 0.000 claims 4
- 102100029205 Low affinity immunoglobulin gamma Fc region receptor II-b Human genes 0.000 claims 4
- 102100034922 T-cell surface glycoprotein CD8 alpha chain Human genes 0.000 claims 4
- 108060008683 Tumor Necrosis Factor Receptor Proteins 0.000 claims 4
- 102100033728 Tumor necrosis factor receptor superfamily member 18 Human genes 0.000 claims 4
- 102100022153 Tumor necrosis factor receptor superfamily member 4 Human genes 0.000 claims 4
- 101710165473 Tumor necrosis factor receptor superfamily member 4 Proteins 0.000 claims 4
- 102100036856 Tumor necrosis factor receptor superfamily member 9 Human genes 0.000 claims 4
- 102000003298 tumor necrosis factor receptor Human genes 0.000 claims 4
- -1 ICOS Proteins 0.000 claims 3
- 150000007523 nucleic acids Chemical class 0.000 claims 3
- 102000039446 nucleic acids Human genes 0.000 claims 3
- 108020004707 nucleic acids Proteins 0.000 claims 3
- 239000013598 vector Substances 0.000 claims 3
- 102100023990 60S ribosomal protein L17 Human genes 0.000 claims 2
- 101001117317 Homo sapiens Programmed cell death 1 ligand 1 Proteins 0.000 claims 2
- 102100024216 Programmed cell death 1 ligand 1 Human genes 0.000 claims 2
- 101710089372 Programmed cell death protein 1 Proteins 0.000 claims 2
- 102100033733 Tumor necrosis factor receptor superfamily member 1B Human genes 0.000 claims 2
- 101710187830 Tumor necrosis factor receptor superfamily member 1B Proteins 0.000 claims 2
- 229960003852 atezolizumab Drugs 0.000 claims 2
- 229960005386 ipilimumab Drugs 0.000 claims 2
- 230000000779 depleting effect Effects 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 229960003301 nivolumab Drugs 0.000 claims 1
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023106715A JP2023129433A (ja) | 2017-07-26 | 2023-06-29 | 新規抗体およびＴｒｅｇ枯渇抗体と免疫刺激性抗体との併用 |
| JP2025116576A JP2025157343A (ja) | 2017-07-26 | 2025-07-10 | 新規抗体およびＴｒｅｇ枯渇抗体と免疫刺激性抗体との併用 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1712032.0A GB201712032D0 (en) | 2017-07-26 | 2017-07-26 | Antibodies and uses thereof |
| GB1712032.0 | 2017-07-26 | ||
| PCT/EP2018/070359 WO2019020774A2 (en) | 2017-07-26 | 2018-07-26 | NOVEL ANTIBODIES AND COMBINED USE OF ANTIBODY THAT INDUCES TREG DEPLOYMENT AND AN IMMUNOSTIMULATOR ANTIBODY |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023106715A Division JP2023129433A (ja) | 2017-07-26 | 2023-06-29 | 新規抗体およびＴｒｅｇ枯渇抗体と免疫刺激性抗体との併用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020528765A JP2020528765A (ja) | 2020-10-01 |
| JP2020528765A5 true JP2020528765A5 (https=) | 2021-07-26 |
| JP7458973B2 JP7458973B2 (ja) | 2024-04-01 |
Family
ID=59771732
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020526685A Active JP7458973B2 (ja) | 2017-07-26 | 2018-07-26 | 新規抗体およびＴｒｅｇ枯渇抗体と免疫刺激性抗体との併用 |
| JP2023106715A Pending JP2023129433A (ja) | 2017-07-26 | 2023-06-29 | 新規抗体およびＴｒｅｇ枯渇抗体と免疫刺激性抗体との併用 |
| JP2025116576A Pending JP2025157343A (ja) | 2017-07-26 | 2025-07-10 | 新規抗体およびＴｒｅｇ枯渇抗体と免疫刺激性抗体との併用 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023106715A Pending JP2023129433A (ja) | 2017-07-26 | 2023-06-29 | 新規抗体およびＴｒｅｇ枯渇抗体と免疫刺激性抗体との併用 |
| JP2025116576A Pending JP2025157343A (ja) | 2017-07-26 | 2025-07-10 | 新規抗体およびＴｒｅｇ枯渇抗体と免疫刺激性抗体との併用 |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US11447549B2 (https=) |
| EP (1) | EP3658587A2 (https=) |
| JP (3) | JP7458973B2 (https=) |
| CN (1) | CN111108124B (https=) |
| AU (1) | AU2018305209B2 (https=) |
| CA (1) | CA3070290A1 (https=) |
| GB (1) | GB201712032D0 (https=) |
| WO (1) | WO2019020774A2 (https=) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20220032642A (ko) * | 2016-04-07 | 2022-03-15 | 캔써 리서치 테크놀로지 리미티드 | 종양 특이적 세포 고갈을 위한 항 cd25 fc 감마 수용체 이중특이적 항체 |
| CN111511762B (zh) | 2017-08-21 | 2025-05-06 | 天演药业公司 | 抗cd137分子及其用途 |
| WO2019148444A1 (en) | 2018-02-02 | 2019-08-08 | Adagene Inc. | Anti-ctla4 antibodies and methods of making and using the same |
| AU2019312200B2 (en) | 2018-07-23 | 2024-11-14 | Heidelberg Pharma Research Gmbh | Use of anti-CD137 antibody drug conjugate (ADC) in allogeneic cell therapy |
| PL3623798T3 (pl) * | 2018-09-13 | 2022-03-28 | Euroimmun Medizinische Labordiagnostika Ag | Sposób i urządzenie do wykrywania i przedstawiania obrazu immunofluorescencyjnego próbki biologicznej |
| SG11202110287QA (en) | 2019-04-24 | 2021-10-28 | Heidelberg Pharma Res Gmbh | Amatoxin antibody-drug conjugates and uses thereof |
| US11246906B2 (en) * | 2019-06-11 | 2022-02-15 | Alkermes Pharma Ireland Limited | Compositions and methods for subcutaneous administration of cancer immunotherapy |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3122779B1 (en) * | 2014-03-24 | 2019-05-22 | Cancer Research Technology Limited | Modified antibodies containing modified igg2 domains which elicit agonist or antagonistic properties and use thereof |
| WO2015188047A1 (en) * | 2014-06-06 | 2015-12-10 | University Of Maryland, Baltimore | ANTI-CD-137 MONOCLONAL ANTIBODIES WITH DISTINCT FcγR BINDING ABILITIES FOR TREATMENT OF CANCER OR AUTOIMMUNITY |
| US20170247455A1 (en) * | 2014-08-22 | 2017-08-31 | Bristol-Myers Squibb Company | Treatment of cancer using a combination of an anti-pd-1 antibody and an anti-cd137 antibody |
| CN107207594B (zh) | 2014-12-23 | 2019-05-07 | 百时美施贵宝公司 | 针对tigit的抗体 |
| TWI719970B (zh) | 2015-03-23 | 2021-03-01 | 美商永斯醫療股份有限公司 | 針對ｉｃｏｓ之抗體 |
| HK1251474A1 (zh) * | 2015-06-08 | 2019-02-01 | 豪夫迈‧罗氏有限公司 | 使用抗ox40抗体和pd-1轴结合拮抗剂治疗癌症的方法 |
| GB201519481D0 (en) | 2015-11-04 | 2015-12-16 | Cancer Rec Tech Ltd | Immunomodulatory antibodies |
| KR20220032642A (ko) * | 2016-04-07 | 2022-03-15 | 캔써 리서치 테크놀로지 리미티드 | 종양 특이적 세포 고갈을 위한 항 cd25 fc 감마 수용체 이중특이적 항체 |
| BR112019025913A2 (pt) | 2017-06-09 | 2020-06-30 | Glaxosmithkline Intellectual Property Development Limited | métodos para tratar câncer em um paciente em necesssidade do mesmo e para produzir um anticorpo, anticorpo anti-icos ou fragmento de ligação ao antígeno do mesmo e um anticorpo anti-ox40 ou fragmento de ligação ao antígeno do mesmo, uso de um anticorpo anti-icos ou porção de ligação ao antígeno do mesmo e um anticorpo anti-ox40 ou porção de ligação ao antígeno do mesmo na fabricação de um medicamento, polinucleotídeo que codifica um anticorpo, vetor, e, célula hospedeira. |
-
2017
- 2017-07-26 GB GBGB1712032.0A patent/GB201712032D0/en not_active Ceased
-
2018
- 2018-07-26 EP EP18753084.5A patent/EP3658587A2/en active Pending
- 2018-07-26 CN CN201880050094.XA patent/CN111108124B/zh active Active
- 2018-07-26 CA CA3070290A patent/CA3070290A1/en active Pending
- 2018-07-26 WO PCT/EP2018/070359 patent/WO2019020774A2/en not_active Ceased
- 2018-07-26 JP JP2020526685A patent/JP7458973B2/ja active Active
- 2018-07-26 US US16/633,740 patent/US11447549B2/en active Active
- 2018-07-26 AU AU2018305209A patent/AU2018305209B2/en active Active
-
2022
- 2022-08-11 US US17/819,234 patent/US20230058227A1/en active Pending
-
2023
- 2023-06-29 JP JP2023106715A patent/JP2023129433A/ja active Pending
-
2025
- 2025-07-10 JP JP2025116576A patent/JP2025157343A/ja active Pending
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