JP2020528747A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2020528747A5 JP2020528747A5 JP2020502582A JP2020502582A JP2020528747A5 JP 2020528747 A5 JP2020528747 A5 JP 2020528747A5 JP 2020502582 A JP2020502582 A JP 2020502582A JP 2020502582 A JP2020502582 A JP 2020502582A JP 2020528747 A5 JP2020528747 A5 JP 2020528747A5
- Authority
- JP
- Japan
- Prior art keywords
- antigen
- activating
- presenting
- cells
- molecule
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 210000001744 T-lymphocyte Anatomy 0.000 claims 29
- 238000000034 method Methods 0.000 claims 24
- 239000003446 ligand Substances 0.000 claims 23
- 230000003213 activating effect Effects 0.000 claims 21
- 108091008874 T cell receptors Proteins 0.000 claims 19
- 102000016266 T-Cell Antigen Receptors Human genes 0.000 claims 19
- 230000027455 binding Effects 0.000 claims 15
- 239000000427 antigen Substances 0.000 claims 8
- 102000036639 antigens Human genes 0.000 claims 8
- 108091007433 antigens Proteins 0.000 claims 8
- 239000012634 fragment Substances 0.000 claims 8
- 239000011324 bead Substances 0.000 claims 7
- 108700018351 Major Histocompatibility Complex Proteins 0.000 claims 6
- 206010028980 Neoplasm Diseases 0.000 claims 5
- 230000020382 suppression by virus of host antigen processing and presentation of peptide antigen via MHC class I Effects 0.000 claims 5
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 claims 4
- 102100028976 HLA class I histocompatibility antigen, B alpha chain Human genes 0.000 claims 4
- 108010088652 Histocompatibility Antigens Class I Proteins 0.000 claims 4
- 101000914514 Homo sapiens T-cell-specific surface glycoprotein CD28 Proteins 0.000 claims 4
- 102100027213 T-cell-specific surface glycoprotein CD28 Human genes 0.000 claims 4
- 230000004913 activation Effects 0.000 claims 4
- 230000000903 blocking effect Effects 0.000 claims 4
- 102100025237 T-cell surface antigen CD2 Human genes 0.000 claims 3
- 230000030741 antigen processing and presentation Effects 0.000 claims 3
- 238000012258 culturing Methods 0.000 claims 3
- 102000009465 Growth Factor Receptors Human genes 0.000 claims 2
- 108010009202 Growth Factor Receptors Proteins 0.000 claims 2
- 101000578784 Homo sapiens Melanoma antigen recognized by T-cells 1 Proteins 0.000 claims 2
- 101001094545 Homo sapiens Retrotransposon-like protein 1 Proteins 0.000 claims 2
- 101000837401 Homo sapiens T-cell leukemia/lymphoma protein 1A Proteins 0.000 claims 2
- 101000807990 Homo sapiens Variable charge X-linked protein 3 Proteins 0.000 claims 2
- 102100028389 Melanoma antigen recognized by T-cells 1 Human genes 0.000 claims 2
- 102100037258 Membrane-associated transporter protein Human genes 0.000 claims 2
- 239000002202 Polyethylene glycol Substances 0.000 claims 2
- 108091007563 SLC45A2 Proteins 0.000 claims 2
- 108010090804 Streptavidin Proteins 0.000 claims 2
- 102100028676 T-cell leukemia/lymphoma protein 1A Human genes 0.000 claims 2
- 102100038978 Variable charge X-linked protein 3 Human genes 0.000 claims 2
- 229960002685 biotin Drugs 0.000 claims 2
- 235000020958 biotin Nutrition 0.000 claims 2
- 239000011616 biotin Substances 0.000 claims 2
- 230000008878 coupling Effects 0.000 claims 2
- 238000010168 coupling process Methods 0.000 claims 2
- 238000005859 coupling reaction Methods 0.000 claims 2
- 229920001223 polyethylene glycol Polymers 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 1
- 150000001735 carboxylic acids Chemical group 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
- 239000000919 ceramic Substances 0.000 claims 1
- 239000003153 chemical reaction reagent Substances 0.000 claims 1
- 230000006690 co-activation Effects 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000011521 glass Substances 0.000 claims 1
- 239000002184 metal Substances 0.000 claims 1
- 229910044991 metal oxide Inorganic materials 0.000 claims 1
- 150000004706 metal oxides Chemical class 0.000 claims 1
- 229920000642 polymer Polymers 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023181879A JP2024020231A (ja) | 2017-07-21 | 2023-10-23 | 抗原提示合成表面、共有結合官能化表面、活性化ｔ細胞及びそれらの使用 |
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762535742P | 2017-07-21 | 2017-07-21 | |
| US62/535,742 | 2017-07-21 | ||
| US201862660779P | 2018-04-20 | 2018-04-20 | |
| US62/660,779 | 2018-04-20 | ||
| US201862664279P | 2018-04-30 | 2018-04-30 | |
| US62/664,279 | 2018-04-30 | ||
| PCT/US2018/043146 WO2019018801A1 (en) | 2017-07-21 | 2018-07-20 | SYNTHETIC SURFACES FOR PRESENTING ANTIGENS, COVALENTLY FUNCTIONALIZED SURFACES, ACTIVATED T CELLS AND USES THEREOF |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023181879A Division JP2024020231A (ja) | 2017-07-21 | 2023-10-23 | 抗原提示合成表面、共有結合官能化表面、活性化ｔ細胞及びそれらの使用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2020528747A JP2020528747A (ja) | 2020-10-01 |
| JP2020528747A5 true JP2020528747A5 (enExample) | 2021-08-26 |
Family
ID=65015614
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020502582A Pending JP2020528747A (ja) | 2017-07-21 | 2018-07-20 | 抗原提示合成表面、共有結合官能化表面、活性化ｔ細胞及びそれらの使用 |
| JP2023181879A Withdrawn JP2024020231A (ja) | 2017-07-21 | 2023-10-23 | 抗原提示合成表面、共有結合官能化表面、活性化ｔ細胞及びそれらの使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023181879A Withdrawn JP2024020231A (ja) | 2017-07-21 | 2023-10-23 | 抗原提示合成表面、共有結合官能化表面、活性化ｔ細胞及びそれらの使用 |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US20200299351A1 (enExample) |
| EP (2) | EP4620977A3 (enExample) |
| JP (2) | JP2020528747A (enExample) |
| KR (1) | KR20200030593A (enExample) |
| CN (2) | CN111107871A (enExample) |
| AU (1) | AU2018304543A1 (enExample) |
| CA (1) | CA3070289A1 (enExample) |
| IL (1) | IL272151A (enExample) |
| SG (1) | SG11202000425QA (enExample) |
| TW (1) | TWI832820B (enExample) |
| WO (1) | WO2019018801A1 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10799865B2 (en) | 2015-10-27 | 2020-10-13 | Berkeley Lights, Inc. | Microfluidic apparatus having an optimized electrowetting surface and related systems and methods |
| IL263274B2 (en) | 2016-05-26 | 2023-10-01 | Berkeley Lights Inc | Covalently adapted surfaces, kits and methods for their production and uses |
| CA3112813A1 (en) | 2018-09-21 | 2020-03-26 | Berkeley Lights, Inc. | Functionalized well plate, methods of preparation and use thereof |
| AU2019371417A1 (en) | 2018-11-01 | 2021-06-17 | Berkeley Lights, Inc. | Methods for assaying biological cells in a microfluidic device |
| WO2020168258A1 (en) | 2019-02-15 | 2020-08-20 | Berkeley Lights, Inc. | Laser-assisted repositioning of a micro-object and culturing of an attachment-dependent cell in a microfluidic environment |
| WO2020223555A1 (en) | 2019-04-30 | 2020-11-05 | Berkeley Lights, Inc. | Methods for encapsulating and assaying cells |
| JP7338077B2 (ja) * | 2020-12-31 | 2023-09-04 | アカデミア シニカ | 細胞培養基材、その方法および使用 |
| US12275932B2 (en) * | 2021-04-28 | 2025-04-15 | A.U. Vista, Inc. | TFT-based cell isolation device and cell manipulation panel thereof |
| WO2023161961A1 (en) * | 2022-02-24 | 2023-08-31 | Lymphon Biologics Pvt. Ltd. | A system and method for t cell activation and immunomodulation |
| WO2025111584A1 (en) * | 2023-11-22 | 2025-05-30 | Georgia Tech Research Corporation | An electronic microfluidic platform for on-chip apoptosis quantification using annexin v-based ps externalization detection |
Family Cites Families (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4690915A (en) | 1985-08-08 | 1987-09-01 | The United States Of America As Represented By The Department Of Health And Human Services | Adoptive immunotherapy as a treatment modality in humans |
| US5827642A (en) | 1994-08-31 | 1998-10-27 | Fred Hutchinson Cancer Research Center | Rapid expansion method ("REM") for in vitro propagation of T lymphocytes |
| EP0814838B1 (en) * | 1995-03-08 | 2003-05-14 | The Scripps Research Institute | Antigen presenting system and activation of t-cells |
| JP2000184880A (ja) * | 1998-10-14 | 2000-07-04 | Kanegafuchi Chem Ind Co Ltd | ガン細胞特異的傷害性ｔ細胞の増殖・活性化誘導方法及びそれに用いるデバイス |
| US6294063B1 (en) | 1999-02-12 | 2001-09-25 | Board Of Regents, The University Of Texas System | Method and apparatus for programmable fluidic processing |
| US6942776B2 (en) | 1999-05-18 | 2005-09-13 | Silicon Biosystems S.R.L. | Method and apparatus for the manipulation of particles by means of dielectrophoresis |
| NZ533466A (en) | 1999-06-28 | 2005-10-28 | California Inst Of Techn | Microfabricated elastomeric valve and pump systems |
| BR0108545A (pt) * | 2000-02-24 | 2004-06-29 | Xcyte Therapies Inc | Estimulação e concentração simultâneas das células |
| US20020044948A1 (en) * | 2000-03-15 | 2002-04-18 | Samir Khleif | Methods and compositions for co-stimulation of immunological responses to peptide antigens |
| US20150329617A1 (en) * | 2001-03-14 | 2015-11-19 | Dynal Biotech Asa | Novel MHC molecule constructs, and methods of employing these constructs for diagnosis and therapy, and uses of MHC molecules |
| US20030170238A1 (en) | 2002-03-07 | 2003-09-11 | Gruenberg Micheal L. | Re-activated T-cells for adoptive immunotherapy |
| US7312085B2 (en) * | 2002-04-01 | 2007-12-25 | Fluidigm Corporation | Microfluidic particle-analysis systems |
| US6958132B2 (en) | 2002-05-31 | 2005-10-25 | The Regents Of The University Of California | Systems and methods for optical actuation of microfluidics based on opto-electrowetting |
| DE60334250D1 (de) * | 2003-05-08 | 2010-10-28 | Life Technologies Corp | Erzeugung und isolierung antigenspezifischer t-zellen |
| JP2007537729A (ja) | 2004-04-12 | 2007-12-27 | ザ・レジェンツ・オブ・ザ・ユニバーシティ・オブ・カリフォルニア | 微粒子及び細胞の操作用の光電子ピンセット |
| ES2601896T3 (es) | 2004-11-24 | 2017-02-16 | Fred Hutchinson Cancer Research Center | Procedimientos de uso de la IL-21 en la inmunoterapia adoptiva y la identificación de antígenos tumorales |
| ES2368152T3 (es) * | 2005-07-01 | 2011-11-14 | Txcell S.A. | Obtención de células tr1 específicas de antígenos de los alimentos o de autoantígenos a partir de una población de leucocitos o pbmc. |
| CA2665568C (en) * | 2006-10-04 | 2018-01-09 | Janssen Pharmaceutica, N.V. | Preparation of inactivated artificial antigen presenting cells and their use in cell therapies |
| WO2008091848A2 (en) | 2007-01-22 | 2008-07-31 | Advanced Liquid Logic, Inc. | Surface assisted fluid loading and droplet dispensing |
| WO2008119066A1 (en) | 2007-03-28 | 2008-10-02 | The Regents Of The University Of California | Single-sided lateral-field and phototransistor-based optoelectronic tweezers |
| WO2008121375A2 (en) * | 2007-03-29 | 2008-10-09 | Pacific Biosciences Of California, Inc. | Modified surfaces for immobilization of active molecules |
| WO2009045308A2 (en) | 2007-10-03 | 2009-04-09 | Fred Hutchinson Cancer Research Center | Enhanced generation of cytotoxic t-lymphocytes by il-21 mediated foxp3 suppression |
| KR102095670B1 (ko) | 2010-05-14 | 2020-03-31 | 더 제너럴 하스피톨 코포레이션 | 종양 특이적 신생항원을 확인하는 조성물 및 방법 |
| US9533306B2 (en) | 2010-08-02 | 2017-01-03 | The Regents Of The University Of California | Single sided continuous optoelectrowetting (SCEOW) device for droplet manipulation with light patterns |
| US9511151B2 (en) * | 2010-11-12 | 2016-12-06 | Uti Limited Partnership | Compositions and methods for the prevention and treatment of cancer |
| US9227200B2 (en) | 2011-06-03 | 2016-01-05 | The Regents Of The University Of California | Microfluidic devices with flexible optically transparent electrodes |
| WO2013086500A1 (en) * | 2011-12-09 | 2013-06-13 | The Johns Hopkins University | Artificial antigen presenting cells having a defined and dynamic shape |
| US9857333B2 (en) | 2012-10-31 | 2018-01-02 | Berkeley Lights, Inc. | Pens for biological micro-objects |
| US9403172B2 (en) | 2012-11-08 | 2016-08-02 | Berkeley Lights, Inc. | Circuit based optoelectronic tweezers |
| KR102257305B1 (ko) | 2013-03-28 | 2021-05-28 | 더 유니버시티 오브 브리티쉬 콜롬비아 | 미세유동 장치 및 분비물의 다세포 검정법에서의 그의 사용 방법 |
| US11807675B2 (en) * | 2013-10-03 | 2023-11-07 | The University Of Maryland, Baltimore | Nanoparticle based artificial antigen presenting cell mediated activation of NKT cells |
| SG10202006525PA (en) | 2013-10-22 | 2020-08-28 | Berkeley Lights Inc | Microfluidic devices having isolation pens and methods of testing biological micro-objects with same |
| US9889445B2 (en) | 2013-10-22 | 2018-02-13 | Berkeley Lights, Inc. | Micro-fluidic devices for assaying biological activity |
| IL313845A (en) * | 2014-04-23 | 2024-08-01 | Juno Therapeutics Inc | Methods for enriching or producing immune cell populations for adoptive therapy |
| US20150306599A1 (en) | 2014-04-25 | 2015-10-29 | Berkeley Lights, Inc. | Providing DEP Manipulation Devices And Controllable Electrowetting Devices In The Same Microfluidic Apparatus |
| EP3134739B1 (en) | 2014-04-25 | 2019-07-10 | Berkeley Lights, Inc. | Providing dep manipulation devices and controllable electrowetting devices in the same microfluidic apparatus |
| US20150306598A1 (en) | 2014-04-25 | 2015-10-29 | Berkeley Lights, Inc. | DEP Force Control And Electrowetting Control In Different Sections Of The Same Microfluidic Apparatus |
| AU2015371265B2 (en) * | 2014-12-24 | 2021-06-03 | Neximmune, Inc | Nanoparticle compositions and methods for immunotherapy |
| US10520251B2 (en) | 2015-01-15 | 2019-12-31 | Heraeus Noblelight America Llc | UV light curing systems, and methods of designing and operating the same |
| WO2016166568A1 (en) * | 2015-04-16 | 2016-10-20 | Juno Therapeutics Gmbh | Methods, kits and apparatus for expanding a population of cells |
| TWI808934B (zh) * | 2015-12-31 | 2023-07-21 | 美商伯克利之光生命科技公司 | 經工程化以表現促發炎多肽之腫瘤浸潤細胞 |
| WO2017124101A2 (en) | 2016-01-15 | 2017-07-20 | The Broad Institute Inc. | Semi-permeable arrays for analyzing biological systems and methods of using same |
| CN109196094A (zh) * | 2016-03-17 | 2019-01-11 | 伯克利之光生命科技公司 | 微流体装置中t淋巴细胞的选择和克隆 |
| IL263274B2 (en) | 2016-05-26 | 2023-10-01 | Berkeley Lights Inc | Covalently adapted surfaces, kits and methods for their production and uses |
-
2018
- 2018-07-20 TW TW107125207A patent/TWI832820B/zh not_active IP Right Cessation
- 2018-07-20 WO PCT/US2018/043146 patent/WO2019018801A1/en not_active Ceased
- 2018-07-20 CA CA3070289A patent/CA3070289A1/en active Pending
- 2018-07-20 AU AU2018304543A patent/AU2018304543A1/en not_active Abandoned
- 2018-07-20 JP JP2020502582A patent/JP2020528747A/ja active Pending
- 2018-07-20 EP EP25194457.5A patent/EP4620977A3/en active Pending
- 2018-07-20 CN CN201880058921.XA patent/CN111107871A/zh active Pending
- 2018-07-20 KR KR1020207005086A patent/KR20200030593A/ko not_active Ceased
- 2018-07-20 SG SG11202000425QA patent/SG11202000425QA/en unknown
- 2018-07-20 CN CN202410633579.9A patent/CN118846017A/zh active Pending
- 2018-07-20 EP EP18836214.9A patent/EP3655027B1/en active Active
-
2020
- 2020-01-15 US US16/743,849 patent/US20200299351A1/en not_active Abandoned
- 2020-01-20 IL IL272151A patent/IL272151A/en unknown
-
2023
- 2023-10-23 JP JP2023181879A patent/JP2024020231A/ja not_active Withdrawn
-
2024
- 2024-07-26 US US18/785,725 patent/US20250051417A1/en active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2024020231A5 (enExample) | ||
| US20220195388A1 (en) | Methods, kits and apparatus for expanding a population of cells | |
| Eggermont et al. | Cytokine‐functionalized synthetic dendritic cells for T cell targeted immunotherapies | |
| Casati et al. | Clinical-scale selection and viral transduction of human naïve and central memory CD8+ T cells for adoptive cell therapy of cancer patients | |
| CN107002038B (zh) | 用于识别、富集和/或扩增抗原特异性t细胞的试剂和方法 | |
| Boettcher et al. | Development of CAR T cell therapy in children—A comprehensive overview | |
| Langenkamp et al. | T cell priming by dendritic cells: thresholds for proliferation, differentiation and death and intraclonal functional diversification | |
| JP2022502017A5 (enExample) | ||
| Cardle et al. | Biomaterials in chimeric antigen receptor T-cell process development | |
| US20230399613A1 (en) | Cell compositions comprising antigen-specific t cells for adoptive therapy | |
| JP2023516300A5 (enExample) | ||
| JP6566938B2 (ja) | 免疫療法のための組成物及び方法 | |
| JP2015524810A5 (enExample) | ||
| JP6744906B2 (ja) | 免疫細胞のインビトロ活性化および／または増殖の方法 | |
| Madrahimov et al. | Metal–organic frameworks containing (alkynyl) gold functionalities: a comparative evaluation of solvent-assisted linker exchange, de novo synthesis, and post-synthesis modification | |
| AU2002240818A1 (en) | MHC molecule constructs and their uses for diagnosis and therapy | |
| Tamura et al. | Immunotherapy for multiple myeloma | |
| Hickey et al. | Adaptive nanoparticle platforms for high throughput expansion and detection of antigen-specific T cells | |
| Dahotre et al. | DNA-barcoded pMHC tetramers for detection of single antigen-specific T cells by digital PCR | |
| US20170299585A1 (en) | Compositions, kits, and methods for cell separation | |
| JP7043114B2 (ja) | 細胞を活性化させるための方法およびキット | |
| Li et al. | Sars-cov-2 B epitope-guided neoantigen nanovaccines enhance tumor-specific cd4/cd8 T cell immunity through B cell antigen presentation | |
| JP2020191873A5 (enExample) | ||
| JP2019534684A5 (enExample) | ||
| Gerrits et al. | Semi‐Flexible Immunobrushes Facilitate Effective and Selective Expansion of Antigen‐Specific T Cells |