JP2020528461A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2020528461A5 JP2020528461A5 JP2020526688A JP2020526688A JP2020528461A5 JP 2020528461 A5 JP2020528461 A5 JP 2020528461A5 JP 2020526688 A JP2020526688 A JP 2020526688A JP 2020526688 A JP2020526688 A JP 2020526688A JP 2020528461 A5 JP2020528461 A5 JP 2020528461A5
- Authority
- JP
- Japan
- Prior art keywords
- oligo
- bond
- bonds
- conjugate
- acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229910052757 nitrogen Inorganic materials 0.000 claims 18
- 239000004202 carbamide Substances 0.000 claims 13
- 150000001875 compounds Chemical class 0.000 claims 9
- 229910052760 oxygen Inorganic materials 0.000 claims 8
- 230000002285 radioactive effect Effects 0.000 claims 8
- 150000001768 cations Chemical class 0.000 claims 6
- 125000005647 linker group Chemical group 0.000 claims 6
- 206010028980 Neoplasm Diseases 0.000 claims 5
- 201000011510 cancer Diseases 0.000 claims 5
- RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Substances CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims 5
- 125000000143 2-carboxyethyl group Chemical group [H]OC(=O)C([H])([H])C([H])([H])* 0.000 claims 4
- 239000002253 acid Substances 0.000 claims 4
- 125000004429 atom Chemical group 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 4
- 229910052731 fluorine Inorganic materials 0.000 claims 4
- 125000001153 fluoro group Chemical group F* 0.000 claims 4
- 238000004519 manufacturing process Methods 0.000 claims 4
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 claims 4
- ABTOQLMXBSRXSM-UHFFFAOYSA-N silicon tetrafluoride Chemical compound F[Si](F)(F)F ABTOQLMXBSRXSM-UHFFFAOYSA-N 0.000 claims 4
- SYFGLWDDLZQFNI-UHFFFAOYSA-N 2-[4-(carboxymethyl)-1,4,8,11-tetrazabicyclo[6.6.2]hexadecan-11-yl]acetic acid Chemical compound C1CN(CC(O)=O)CCCN2CCN(CC(=O)O)CCCN1CC2 SYFGLWDDLZQFNI-UHFFFAOYSA-N 0.000 claims 3
- 239000007983 Tris buffer Substances 0.000 claims 3
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims 3
- 125000002947 alkylene group Chemical group 0.000 claims 3
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 3
- 239000002738 chelating agent Substances 0.000 claims 3
- 125000005842 heteroatom Chemical group 0.000 claims 3
- 125000000896 monocarboxylic acid group Chemical group 0.000 claims 3
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- 125000001424 substituent group Chemical group 0.000 claims 3
- GSRZVAGTAJGFRZ-UHFFFAOYSA-N 6-hydrazinyl-n-methylpyridine-3-carboxamide Chemical compound CNC(=O)C1=CC=C(NN)N=C1 GSRZVAGTAJGFRZ-UHFFFAOYSA-N 0.000 claims 2
- 102100041003 Glutamate carboxypeptidase 2 Human genes 0.000 claims 2
- 101000892862 Homo sapiens Glutamate carboxypeptidase 2 Proteins 0.000 claims 2
- QPCDCPDFJACHGM-UHFFFAOYSA-N N,N-bis{2-[bis(carboxymethyl)amino]ethyl}glycine Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(=O)O)CCN(CC(O)=O)CC(O)=O QPCDCPDFJACHGM-UHFFFAOYSA-N 0.000 claims 2
- UBQYURCVBFRUQT-UHFFFAOYSA-N N-benzoyl-Ferrioxamine B Chemical compound CC(=O)N(O)CCCCCNC(=O)CCC(=O)N(O)CCCCCNC(=O)CCC(=O)N(O)CCCCCN UBQYURCVBFRUQT-UHFFFAOYSA-N 0.000 claims 2
- ABLZXFCXXLZCGV-UHFFFAOYSA-N Phosphorous acid Chemical compound OP(O)=O ABLZXFCXXLZCGV-UHFFFAOYSA-N 0.000 claims 2
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical group [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 claims 2
- WDLRUFUQRNWCPK-UHFFFAOYSA-N Tetraxetan Chemical compound OC(=O)CN1CCN(CC(O)=O)CCN(CC(O)=O)CCN(CC(O)=O)CC1 WDLRUFUQRNWCPK-UHFFFAOYSA-N 0.000 claims 2
- 229910052799 carbon Inorganic materials 0.000 claims 2
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 2
- 239000000032 diagnostic agent Substances 0.000 claims 2
- 229940039227 diagnostic agent Drugs 0.000 claims 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 2
- 239000012216 imaging agent Substances 0.000 claims 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 2
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 2
- 229920002601 oligoester Polymers 0.000 claims 2
- 239000001301 oxygen Substances 0.000 claims 2
- 125000004430 oxygen atom Chemical group O* 0.000 claims 2
- 229960003330 pentetic acid Drugs 0.000 claims 2
- ACVYVLVWPXVTIT-UHFFFAOYSA-N phosphinic acid Chemical compound O[PH2]=O ACVYVLVWPXVTIT-UHFFFAOYSA-N 0.000 claims 2
- 229910052698 phosphorus Inorganic materials 0.000 claims 2
- 125000006413 ring segment Chemical group 0.000 claims 2
- 229910052710 silicon Inorganic materials 0.000 claims 2
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 1
- NKIJBSVPDYIEAT-UHFFFAOYSA-N 1,4,7,10-tetrazacyclododec-10-ene Chemical compound C1CNCCN=CCNCCN1 NKIJBSVPDYIEAT-UHFFFAOYSA-N 0.000 claims 1
- KIUIVKNVSSLOAG-UHFFFAOYSA-N 1,4,7,10-tetrazacyclotridecan-11-one Chemical compound O=C1CCNCCNCCNCCN1 KIUIVKNVSSLOAG-UHFFFAOYSA-N 0.000 claims 1
- -1 1-carboxy-3-carboxypropyl Chemical group 0.000 claims 1
- SNUSZUYTMHKCPM-UHFFFAOYSA-N 1-hydroxypyridin-2-one Chemical compound ON1C=CC=CC1=O SNUSZUYTMHKCPM-UHFFFAOYSA-N 0.000 claims 1
- RPNMGUBLKCLAEK-UHFFFAOYSA-N 2-(4-chlorophenyl)sulfanyl-n,n-diethylethanamine;hydrochloride Chemical compound [Cl-].CC[NH+](CC)CCSC1=CC=C(Cl)C=C1 RPNMGUBLKCLAEK-UHFFFAOYSA-N 0.000 claims 1
- FHQWIXXRHHMBQL-UHFFFAOYSA-N 2-[1,3,10-tris(carboxymethyl)-1,3,6,10-tetrazacyclododec-6-yl]acetic acid Chemical compound OC(=O)CN1CCCN(CC(O)=O)CCN(CC(O)=O)CN(CC(O)=O)CC1 FHQWIXXRHHMBQL-UHFFFAOYSA-N 0.000 claims 1
- GRUVVLWKPGIYEG-UHFFFAOYSA-N 2-[2-[carboxymethyl-[(2-hydroxyphenyl)methyl]amino]ethyl-[(2-hydroxyphenyl)methyl]amino]acetic acid Chemical compound C=1C=CC=C(O)C=1CN(CC(=O)O)CCN(CC(O)=O)CC1=CC=CC=C1O GRUVVLWKPGIYEG-UHFFFAOYSA-N 0.000 claims 1
- SQKUFYLUXROIFM-UHFFFAOYSA-N 2-[2-[carboxymethyl-[[3-hydroxy-2-methyl-5-(phosphonooxymethyl)pyridin-4-yl]methyl]amino]ethyl-[[3-hydroxy-2-methyl-5-(phosphonooxymethyl)pyridin-4-yl]methyl]amino]acetic acid Chemical compound CC1=NC=C(COP(O)(O)=O)C(CN(CCN(CC(O)=O)CC=2C(=C(C)N=CC=2COP(O)(O)=O)O)CC(O)=O)=C1O SQKUFYLUXROIFM-UHFFFAOYSA-N 0.000 claims 1
- DZTVAULYUGBHSF-UHFFFAOYSA-N 2-[4,7,10-tris(carboxymethyl)-1,4,7,10-tetrazacyclododec-1-yl]pentanedioic acid Chemical compound OC(=O)CCC(C(O)=O)N1CCN(CC(O)=O)CCN(CC(O)=O)CCN(CC(O)=O)CC1 DZTVAULYUGBHSF-UHFFFAOYSA-N 0.000 claims 1
- JHALWMSZGCVVEM-UHFFFAOYSA-N 2-[4,7-bis(carboxymethyl)-1,4,7-triazonan-1-yl]acetic acid Chemical compound OC(=O)CN1CCN(CC(O)=O)CCN(CC(O)=O)CC1 JHALWMSZGCVVEM-UHFFFAOYSA-N 0.000 claims 1
- 125000000022 2-aminoethyl group Chemical group [H]C([*])([H])C([H])([H])N([H])[H] 0.000 claims 1
- 125000001960 7 membered carbocyclic group Chemical group 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- XSNFRUQUGNIDGC-UHFFFAOYSA-N CN(C=CC(CC(N)=O)=C1O)C1=O Chemical compound CN(C=CC(CC(N)=O)=C1O)C1=O XSNFRUQUGNIDGC-UHFFFAOYSA-N 0.000 claims 1
- 101100243399 Caenorhabditis elegans pept-2 gene Proteins 0.000 claims 1
- 206010009944 Colon cancer Diseases 0.000 claims 1
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims 1
- RPNUMPOLZDHAAY-UHFFFAOYSA-N Diethylenetriamine Chemical compound NCCNCCN RPNUMPOLZDHAAY-UHFFFAOYSA-N 0.000 claims 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
- 206010029113 Neovascularisation Diseases 0.000 claims 1
- LSFODDNIDIWZCJ-UHFFFAOYSA-N OC(=O)CN1CCN(CC(O)=O)CCN(Cc2ccc(cc2)[N+]([O-])=O)N(CC(O)=O)CC1 Chemical compound OC(=O)CN1CCN(CC(O)=O)CCN(Cc2ccc(cc2)[N+]([O-])=O)N(CC(O)=O)CC1 LSFODDNIDIWZCJ-UHFFFAOYSA-N 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
- 208000006265 Renal cell carcinoma Diseases 0.000 claims 1
- RCXMQNIDOFXYDO-UHFFFAOYSA-N [4,7,10-tris(phosphonomethyl)-1,4,7,10-tetrazacyclododec-1-yl]methylphosphonic acid Chemical compound OP(O)(=O)CN1CCN(CP(O)(O)=O)CCN(CP(O)(O)=O)CCN(CP(O)(O)=O)CC1 RCXMQNIDOFXYDO-UHFFFAOYSA-N 0.000 claims 1
- CYJYKTMBMMYRHR-UHFFFAOYSA-N acetic acid;1,4,7-triazonane Chemical compound CC(O)=O.CC(O)=O.CC(O)=O.C1CNCCNCCN1 CYJYKTMBMMYRHR-UHFFFAOYSA-N 0.000 claims 1
- 125000002015 acyclic group Chemical group 0.000 claims 1
- 125000001931 aliphatic group Chemical group 0.000 claims 1
- 150000001412 amines Chemical class 0.000 claims 1
- 230000033115 angiogenesis Effects 0.000 claims 1
- 125000003118 aryl group Chemical group 0.000 claims 1
- 125000002091 cationic group Chemical group 0.000 claims 1
- 239000000562 conjugate Substances 0.000 claims 1
- 238000010276 construction Methods 0.000 claims 1
- 230000008878 coupling Effects 0.000 claims 1
- 238000010168 coupling process Methods 0.000 claims 1
- 238000005859 coupling reaction Methods 0.000 claims 1
- 238000003745 diagnosis Methods 0.000 claims 1
- XBDQKXXYIPTUBI-UHFFFAOYSA-N dimethylselenoniopropionate Natural products CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 claims 1
- 150000002170 ethers Chemical class 0.000 claims 1
- DEFVIWRASFVYLL-UHFFFAOYSA-N ethylene glycol bis(2-aminoethyl)tetraacetic acid Chemical compound OC(=O)CN(CC(O)=O)CCOCCOCCN(CC(O)=O)CC(O)=O DEFVIWRASFVYLL-UHFFFAOYSA-N 0.000 claims 1
- 125000000623 heterocyclic group Chemical group 0.000 claims 1
- 125000001183 hydrocarbyl group Chemical group 0.000 claims 1
- 125000004356 hydroxy functional group Chemical group O* 0.000 claims 1
- 125000006289 hydroxybenzyl group Chemical group 0.000 claims 1
- 238000003384 imaging method Methods 0.000 claims 1
- 239000003446 ligand Substances 0.000 claims 1
- 201000005202 lung cancer Diseases 0.000 claims 1
- 208000020816 lung neoplasm Diseases 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- DUWWHGPELOTTOE-UHFFFAOYSA-N n-(5-chloro-2,4-dimethoxyphenyl)-3-oxobutanamide Chemical compound COC1=CC(OC)=C(NC(=O)CC(C)=O)C=C1Cl DUWWHGPELOTTOE-UHFFFAOYSA-N 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- LFGREXWGYUGZLY-UHFFFAOYSA-N phosphoryl Chemical group [P]=O LFGREXWGYUGZLY-UHFFFAOYSA-N 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 235000019260 propionic acid Nutrition 0.000 claims 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 229910052717 sulfur Inorganic materials 0.000 claims 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022065524A JP2022101601A (ja) | 2017-07-28 | 2022-04-12 | デュアルモードの放射性トレーサーおよび療法剤 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP17183795 | 2017-07-28 | ||
| EP17183795.8 | 2017-07-28 | ||
| PCT/EP2018/070533 WO2019020831A1 (en) | 2017-07-28 | 2018-07-30 | AGENTS WITH TWO RADIOTRATIVE AND THERAPEUTIC MODES |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022065524A Division JP2022101601A (ja) | 2017-07-28 | 2022-04-12 | デュアルモードの放射性トレーサーおよび療法剤 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020528461A JP2020528461A (ja) | 2020-09-24 |
| JP2020528461A5 true JP2020528461A5 (enExample) | 2021-04-01 |
| JP7059372B2 JP7059372B2 (ja) | 2022-04-25 |
Family
ID=59501286
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020526688A Active JP7059372B2 (ja) | 2017-07-28 | 2018-07-30 | デュアルモードの放射性トレーサーおよび療法剤 |
| JP2022065524A Pending JP2022101601A (ja) | 2017-07-28 | 2022-04-12 | デュアルモードの放射性トレーサーおよび療法剤 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022065524A Pending JP2022101601A (ja) | 2017-07-28 | 2022-04-12 | デュアルモードの放射性トレーサーおよび療法剤 |
Country Status (20)
| Country | Link |
|---|---|
| US (3) | US11413360B2 (enExample) |
| EP (3) | EP4000640A1 (enExample) |
| JP (2) | JP7059372B2 (enExample) |
| KR (2) | KR102752620B1 (enExample) |
| CN (1) | CN111132700B (enExample) |
| AU (2) | AU2018308699B2 (enExample) |
| BR (1) | BR112020001785A2 (enExample) |
| CA (1) | CA3071315A1 (enExample) |
| DK (1) | DK3658194T3 (enExample) |
| EA (1) | EA202090370A1 (enExample) |
| ES (1) | ES3011272T3 (enExample) |
| FI (1) | FI3658194T3 (enExample) |
| HU (1) | HUE070098T2 (enExample) |
| IL (2) | IL272291B2 (enExample) |
| MX (2) | MX2020000352A (enExample) |
| PL (1) | PL3658194T3 (enExample) |
| PT (1) | PT3658194T (enExample) |
| SG (1) | SG11202000725WA (enExample) |
| WO (1) | WO2019020831A1 (enExample) |
| ZA (1) | ZA202000467B (enExample) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL3658194T3 (pl) | 2017-07-28 | 2025-09-15 | Technische Universität München | Radioznacznik i środki radioterapeutyczne o podwójnym trybie działania |
| KR20210153036A (ko) * | 2019-01-30 | 2021-12-16 | 테크니쉐 우니베르지테트 뮌헨 | 암 진단 영상화제들 |
| JP7421232B2 (ja) * | 2019-01-30 | 2024-01-24 | テクニシェ ユニバーシタット ミュンヘン | フッ化ケイ素アクセプタ置換放射性医薬品とその前駆体 |
| FI3917626T3 (fi) | 2019-01-30 | 2023-08-17 | Univ Muenchen Tech | Psma:ta sitova kaksimuotoinen radiomerkkiaine ja terapeuttinen aine |
| CN112168978B (zh) * | 2019-07-03 | 2022-01-11 | 北京大学 | 一种抗体偶联药物及其药物组合物与应用 |
| CA3155519A1 (en) * | 2019-10-29 | 2021-05-06 | Steve Shih-Lin Huang | Psma-targeting imaging agents |
| CN113350531A (zh) * | 2020-03-02 | 2021-09-07 | 上海核力星医药科技有限公司 | 前列腺特异性膜抗原结合配体偶联物及其应用 |
| GB202005282D0 (en) * | 2020-04-09 | 2020-05-27 | Blue Earth Diagnostics Ltd | Pharmaceutical Formulations |
| WO2022018264A1 (en) | 2020-07-23 | 2022-01-27 | Technische Universität München | Silicon-containing ligand compounds |
| CA3191472A1 (en) | 2020-09-03 | 2022-03-10 | Curium Us Llc | Radiolabeling and formulation for scale up of 64cu-dotatate |
| EP4023250A1 (en) * | 2021-01-04 | 2022-07-06 | Technische Universität München | Dual mode radiotracer and -therapeutics |
| AU2022219543A1 (en) | 2021-02-15 | 2023-08-17 | Technische Universität München | Dual mode radiotracer and therapeutics |
| AU2022273184A1 (en) * | 2021-05-14 | 2023-10-12 | Technische Universität München | Radiopharmaceutical somatostatin receptor ligands and precursors thereof |
| GB202108779D0 (en) | 2021-06-18 | 2021-08-04 | Blue Earth Diagnostics Ltd | Si-at therapeutic/diagnostic compounds |
| GB202109922D0 (en) | 2021-07-09 | 2021-08-25 | Blue Earth Diagnostics Ltd | Radiotracers and therapeutics binding to fibroblast activation protein (fap) |
| AU2022323741A1 (en) * | 2021-08-05 | 2024-02-01 | Technische Universität München | Ligand compounds comprising a chelating group as a bridging group |
| GB202113646D0 (en) | 2021-09-24 | 2021-11-10 | Blue Earth Diagnostics Ltd | Method of preparation of 18F labelled silyl-fluoride compounds |
| CN114671806B (zh) * | 2022-04-08 | 2024-03-01 | 上海如絮生物科技有限公司 | 一种亲水性吡啶衍生物、中间体、其制备方法及应用 |
| GB202207372D0 (en) | 2022-05-19 | 2022-07-06 | Blue Earth Diagnostics Ltd | Synthesis of fluorosilyl compounds |
| WO2024023332A1 (en) | 2022-07-29 | 2024-02-01 | Technische Universität München | Silicon-based fluoride acceptor groups for radiopharmaceuticals |
| WO2024054226A1 (en) * | 2022-09-06 | 2024-03-14 | Hoang Ba Xuan | Gallium nitrate and dimethyl sulfoxide composition for respiratory treatment |
| EP4631959A3 (en) * | 2022-09-20 | 2025-12-17 | Technische Universität München, in Vertretung des Freistaats Bayern | Novel minigastrin-derived cholecystokinin 2 receptor binding molecules for imaging and targeted radiotherapy |
| TW202426433A (zh) | 2022-09-23 | 2024-07-01 | 瑞士商紐利迪姆股份公司 | 成纖維細胞活化蛋白（ｆａｐ）抑制劑、ｆａｐ結合物及其診斷與治療用途 |
| CN120417945A (zh) * | 2022-11-14 | 2025-08-01 | 阿克提斯肿瘤学公司 | 肾脏中小蛋白滞留的减少 |
| WO2025072791A2 (en) | 2023-09-29 | 2025-04-03 | Aktis Oncology, Inc. | Miniproteins, conjugates & uses thereof |
| GB202316239D0 (en) | 2023-10-24 | 2023-12-06 | Blue Earth Diagnostics Ltd | Therapeutic combination |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1995001346A1 (en) * | 1993-06-30 | 1995-01-12 | Akzo Nobel N.V. | Chelating compounds |
| JP2005519861A (ja) * | 2001-07-27 | 2005-07-07 | ターゲサム・インコーポレーテッド | 治療剤及び撮像剤としての脂質構築物 |
| CN102626522B (zh) * | 2012-04-12 | 2014-09-10 | 韩彦江 | 基于趋化因子受体cxcr4多肽类拮抗剂的多肽放射性诊断与治疗药物 |
| US10799605B2 (en) * | 2014-06-10 | 2020-10-13 | 3B Pharmaceuticals Gmbh | Conjugate comprising a neurotensin receptor ligand and use thereof |
| WO2016062370A1 (en) | 2014-10-20 | 2016-04-28 | Deutsches Krebsforschungszentrum | 18f-tagged inhibitors of prostate specific membrane antigen (psma), their use as imaging agents and pharmaceutical agents for the treatment of prostate cancer |
| US20160287730A1 (en) * | 2015-03-31 | 2016-10-06 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Serv | Labeled evans blue dye derivative for in vivo serum albumin labeling |
| JP7266365B2 (ja) * | 2015-05-26 | 2023-04-28 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 分子および生体分子の１８ｆ標識化に有用な新規な複素芳香環フッ化ケイ素アクセプタおよびその調製方法 |
| PL3658194T3 (pl) | 2017-07-28 | 2025-09-15 | Technische Universität München | Radioznacznik i środki radioterapeutyczne o podwójnym trybie działania |
| CN116617421A (zh) * | 2017-12-11 | 2023-08-22 | 慕尼黑工业大学 | 用于诊断和/或治疗的药物组合物 |
| FI3917626T3 (fi) | 2019-01-30 | 2023-08-17 | Univ Muenchen Tech | Psma:ta sitova kaksimuotoinen radiomerkkiaine ja terapeuttinen aine |
| KR20210153036A (ko) | 2019-01-30 | 2021-12-16 | 테크니쉐 우니베르지테트 뮌헨 | 암 진단 영상화제들 |
-
2018
- 2018-07-30 PL PL18743540.9T patent/PL3658194T3/pl unknown
- 2018-07-30 IL IL272291A patent/IL272291B2/en unknown
- 2018-07-30 PT PT187435409T patent/PT3658194T/pt unknown
- 2018-07-30 AU AU2018308699A patent/AU2018308699B2/en active Active
- 2018-07-30 ES ES18743540T patent/ES3011272T3/es active Active
- 2018-07-30 BR BR112020001785-0A patent/BR112020001785A2/pt unknown
- 2018-07-30 EP EP22150556.3A patent/EP4000640A1/en not_active Withdrawn
- 2018-07-30 SG SG11202000725WA patent/SG11202000725WA/en unknown
- 2018-07-30 US US16/634,759 patent/US11413360B2/en active Active
- 2018-07-30 FI FIEP18743540.9T patent/FI3658194T3/fi active
- 2018-07-30 KR KR1020207005589A patent/KR102752620B1/ko active Active
- 2018-07-30 CA CA3071315A patent/CA3071315A1/en active Pending
- 2018-07-30 EP EP24184312.7A patent/EP4424378A3/en active Pending
- 2018-07-30 IL IL318092A patent/IL318092A/en unknown
- 2018-07-30 DK DK18743540.9T patent/DK3658194T3/da active
- 2018-07-30 CN CN201880062949.0A patent/CN111132700B/zh active Active
- 2018-07-30 EA EA202090370A patent/EA202090370A1/ru unknown
- 2018-07-30 JP JP2020526688A patent/JP7059372B2/ja active Active
- 2018-07-30 EP EP18743540.9A patent/EP3658194B1/en active Active
- 2018-07-30 KR KR1020247006169A patent/KR20240027896A/ko not_active Ceased
- 2018-07-30 WO PCT/EP2018/070533 patent/WO2019020831A1/en not_active Ceased
- 2018-07-30 HU HUE18743540A patent/HUE070098T2/hu unknown
- 2018-07-30 MX MX2020000352A patent/MX2020000352A/es unknown
-
2020
- 2020-01-10 MX MX2023007914A patent/MX2023007914A/es unknown
- 2020-01-23 ZA ZA2020/00467A patent/ZA202000467B/en unknown
-
2022
- 2022-04-12 JP JP2022065524A patent/JP2022101601A/ja active Pending
- 2022-06-24 US US17/849,297 patent/US12390540B2/en active Active
-
2024
- 2024-01-24 AU AU2024200440A patent/AU2024200440B2/en active Active
- 2024-11-15 US US18/948,808 patent/US12453787B2/en active Active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2020528461A5 (enExample) | ||
| CN113573743B (zh) | 癌症诊断成像剂 | |
| CA2225453C (en) | Compounds with chelation affinity and selectivity for first transition series elements, and their use in medical therapy and diagnosis | |
| JP2023139063A (ja) | 画像化および内部放射線療法のためのｐｓｍａリガンド | |
| AU2018308699A1 (en) | Dual mode radiotracer and -therapeutics | |
| RU2019139432A (ru) | Фармакокинетическая оптимизация бифункциональных хелатов и их применение | |
| RU2017114360A (ru) | Радиофармацевтический конъюгат | |
| US12427207B2 (en) | Pharmaceutical formulations | |
| CN107847618B (zh) | Hbed-二膦酸盐/酯、其放射金属轭合物和它们作为治疗诊断剂的用途 | |
| US20250375544A1 (en) | Dual mode radiotracer and -therapeutics | |
| AU2016368542A1 (en) | Contrast agents | |
| JP2018523671A5 (enExample) | ||
| Urbanovský et al. | Lanthanide complexes of DO3A–(Dibenzylamino) methylphosphinate: effect of Protonation of the Dibenzylamino Group on the water-exchange rate and the binding of human serum albumin | |
| JP2011504510A5 (enExample) | ||
| IL305134A (en) | Dual mode radio and medical tracker | |
| JPWO2023283627A5 (enExample) | ||
| EA050309B1 (ru) | Фармацевтические составы | |
| WO2025087896A1 (en) | Therapeutic combination | |
| RU2024127322A (ru) | Соединения и радиолиганды для нацеливания на рецептор нейротензина и их применение | |
| HK1248585A1 (en) | Hbed-bisphosphonates, radiometal conjugates thereof and their use as theranostic agents |