JP2020526583A5 - - Google Patents
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- Publication number
- JP2020526583A5 JP2020526583A5 JP2020521496A JP2020521496A JP2020526583A5 JP 2020526583 A5 JP2020526583 A5 JP 2020526583A5 JP 2020521496 A JP2020521496 A JP 2020521496A JP 2020521496 A JP2020521496 A JP 2020521496A JP 2020526583 A5 JP2020526583 A5 JP 2020526583A5
- Authority
- JP
- Japan
- Prior art keywords
- aqueous
- lactobacillus
- dry powder
- bacterial suspension
- storage medium
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000843 powder Substances 0.000 claims description 38
- 230000001580 bacterial effect Effects 0.000 claims description 27
- 238000000034 method Methods 0.000 claims description 26
- 239000000654 additive Substances 0.000 claims description 25
- 239000000725 suspension Substances 0.000 claims description 23
- 241000186660 Lactobacillus Species 0.000 claims description 22
- 230000000996 additive effect Effects 0.000 claims description 20
- 229940039696 lactobacillus Drugs 0.000 claims description 12
- 239000008188 pellet Substances 0.000 claims description 12
- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 claims description 10
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 claims description 10
- HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 claims description 10
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 claims description 10
- HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 claims description 10
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 claims description 10
- 235000010378 sodium ascorbate Nutrition 0.000 claims description 10
- PPASLZSBLFJQEF-RKJRWTFHSA-M sodium ascorbate Substances [Na+].OC[C@@H](O)[C@H]1OC(=O)C(O)=C1[O-] PPASLZSBLFJQEF-RKJRWTFHSA-M 0.000 claims description 10
- 229960005055 sodium ascorbate Drugs 0.000 claims description 10
- 239000001488 sodium phosphate Substances 0.000 claims description 10
- 229910000162 sodium phosphate Inorganic materials 0.000 claims description 10
- PPASLZSBLFJQEF-RXSVEWSESA-M sodium-L-ascorbate Chemical compound [Na+].OC[C@H](O)[C@H]1OC(=O)C(O)=C1[O-] PPASLZSBLFJQEF-RXSVEWSESA-M 0.000 claims description 10
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 claims description 10
- 239000000811 xylitol Substances 0.000 claims description 10
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 claims description 10
- 229960002675 xylitol Drugs 0.000 claims description 10
- 235000010447 xylitol Nutrition 0.000 claims description 10
- PXEDJBXQKAGXNJ-QTNFYWBSSA-L disodium L-glutamate Chemical compound [Na+].[Na+].[O-]C(=O)[C@@H](N)CCC([O-])=O PXEDJBXQKAGXNJ-QTNFYWBSSA-L 0.000 claims description 8
- 235000013923 monosodium glutamate Nutrition 0.000 claims description 8
- 229940073490 sodium glutamate Drugs 0.000 claims description 8
- 241000218492 Lactobacillus crispatus Species 0.000 claims description 7
- 241000186606 Lactobacillus gasseri Species 0.000 claims description 7
- 230000002159 abnormal effect Effects 0.000 claims description 6
- 230000003115 biocidal effect Effects 0.000 claims description 6
- 230000000694 effects Effects 0.000 claims description 6
- 244000005706 microflora Species 0.000 claims description 6
- 229920002774 Maltodextrin Polymers 0.000 claims description 5
- 239000005913 Maltodextrin Substances 0.000 claims description 5
- 239000003242 anti bacterial agent Substances 0.000 claims description 5
- 229940088710 antibiotic agent Drugs 0.000 claims description 5
- 229940035034 maltodextrin Drugs 0.000 claims description 5
- VAOCPAMSLUNLGC-UHFFFAOYSA-N metronidazole Chemical compound CC1=NC=C([N+]([O-])=O)N1CCO VAOCPAMSLUNLGC-UHFFFAOYSA-N 0.000 claims description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 5
- 229960000282 metronidazole Drugs 0.000 claims description 4
- 239000007900 aqueous suspension Substances 0.000 claims description 3
- HJLSLZFTEKNLFI-UHFFFAOYSA-N Tinidazole Chemical compound CCS(=O)(=O)CCN1C(C)=NC=C1[N+]([O-])=O HJLSLZFTEKNLFI-UHFFFAOYSA-N 0.000 claims description 2
- 229960002227 clindamycin Drugs 0.000 claims description 2
- KDLRVYVGXIQJDK-AWPVFWJPSA-N clindamycin Chemical compound CN1C[C@H](CCC)C[C@H]1C(=O)N[C@H]([C@H](C)Cl)[C@@H]1[C@H](O)[C@H](O)[C@@H](O)[C@@H](SC)O1 KDLRVYVGXIQJDK-AWPVFWJPSA-N 0.000 claims description 2
- 229960005053 tinidazole Drugs 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims 6
- 241001561398 Lactobacillus jensenii Species 0.000 claims 4
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 229940079593 drug Drugs 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 239000008176 lyophilized powder Substances 0.000 claims 1
- 241000894007 species Species 0.000 claims 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 3
- 229940127557 pharmaceutical product Drugs 0.000 description 3
- 241000186783 Lactobacillus vaginalis Species 0.000 description 2
- 229940063189 metrogel Drugs 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762529756P | 2017-07-07 | 2017-07-07 | |
| US62/529,756 | 2017-07-07 | ||
| PCT/US2018/040884 WO2019010282A1 (en) | 2017-07-07 | 2018-07-05 | STABILIZED FORMULATIONS WITH HIGH POWER OF LACTOBACILLUS VAGINAL |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020526583A JP2020526583A (ja) | 2020-08-31 |
| JP2020526583A5 true JP2020526583A5 (https=) | 2021-08-12 |
| JP7347760B2 JP7347760B2 (ja) | 2023-09-20 |
Family
ID=64950361
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020521496A Active JP7347760B2 (ja) | 2017-07-07 | 2018-07-05 | 高効力かつ安定な膣ラクトバチルス調製物 |
Country Status (6)
| Country | Link |
|---|---|
| US (3) | US20200171107A1 (https=) |
| EP (1) | EP3648778A4 (https=) |
| JP (1) | JP7347760B2 (https=) |
| CN (1) | CN110869036B (https=) |
| AU (1) | AU2018298117B2 (https=) |
| WO (1) | WO2019010282A1 (https=) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3648779A4 (en) * | 2017-07-07 | 2021-03-17 | Osel, Inc. | USING VAGINAL LACTOBACILLI TO IMPROVE THE SUCCESS RATE OF IN VITRO FERTILIZATION |
| WO2019010282A1 (en) * | 2017-07-07 | 2019-01-10 | Osel, Inc. | STABILIZED FORMULATIONS WITH HIGH POWER OF LACTOBACILLUS VAGINAL |
| TWI737210B (zh) * | 2020-03-06 | 2021-08-21 | 財團法人食品工業發展研究所 | 菌酛保護劑配方及其用途 |
| CN113755357A (zh) * | 2020-06-04 | 2021-12-07 | 内蒙古伊利实业集团股份有限公司 | 一种乳杆菌制剂及其用途 |
| EP4294417A1 (en) | 2021-02-19 | 2023-12-27 | Imperial College Innovations Limited | Lactobacillus crispatus composition for use in pregnant subjects |
| CN117241810A (zh) * | 2021-03-03 | 2023-12-15 | 弗雷亚生命科学公司 | 阴道微生物群相关方法、组合物和装置 |
| US12185767B2 (en) * | 2021-11-05 | 2025-01-07 | Trillium Medical Products, LLC | Infused undergarment |
| WO2025016986A1 (en) * | 2023-07-14 | 2025-01-23 | Dsm Ip Assets B.V. | Lactic acid bacteria composition |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2463768A (en) * | 1945-09-05 | 1949-03-08 | Phillips Petroleum Co | Alkylation process |
| US3897307A (en) * | 1974-10-23 | 1975-07-29 | Hansens Lab Inc | Stabilized dry cultures of lactic acid-producing bacteria |
| US6093941A (en) | 1993-09-09 | 2000-07-25 | The United States Of America As Represented By The Secretary Of The Navy | Photonic silicon on a transparent substrate |
| HUP9904266A3 (en) * | 1996-09-10 | 2000-06-28 | Nestle Sa | Dehydrated food containing lactic acid bacteria |
| US6093394A (en) * | 1997-04-11 | 2000-07-25 | Gynelogix, Inc. | Vaginal lactobacillus medicant |
| SE521022C2 (sv) * | 2001-09-20 | 2003-09-23 | Ellen Ab | Mjölksyraproducerande bakterier för användning som probiotiska organismer i vaginan hos människa |
| US20110066137A1 (en) * | 2007-12-18 | 2011-03-17 | Osel, Inc. | Applicator for applying powder formulations and uses thereof |
| US8642029B2 (en) * | 2008-03-31 | 2014-02-04 | Osel, Inc. | Transiently buffered Lactobacillus preparations and use thereof |
| US8329447B2 (en) * | 2008-12-12 | 2012-12-11 | Osel, Inc. | Strain of Lactobacillus crispatus |
| WO2010124855A1 (en) * | 2009-04-30 | 2010-11-04 | Actogenix Nv | Cryoprotectants for freeze drying of lactic acid bacteria |
| WO2012021783A2 (en) * | 2010-08-13 | 2012-02-16 | Advanced Bionutrition Corporation | Dry storage stabilizing composition for biological materials |
| FR2992973B1 (fr) * | 2012-07-09 | 2015-12-18 | S P M D | Nouvelle souche de lactobacillus crispatus |
| CN102757922B (zh) | 2012-07-30 | 2013-11-20 | 陕西省科学院酶工程研究所 | 嗜酸乳杆菌复合冻干保护剂及其制备和使用方法 |
| US8906668B2 (en) * | 2012-11-23 | 2014-12-09 | Seres Health, Inc. | Synergistic bacterial compositions and methods of production and use thereof |
| WO2014106541A1 (en) * | 2013-01-04 | 2014-07-10 | Ellen Ab | Dermal composition for use in the external genital area in females |
| CN104178437B (zh) * | 2013-11-08 | 2016-08-24 | 苏州欧赛微科生物医药科技有限公司 | 一种卷曲乳杆菌及其在妇科疾病中的应用 |
| SG11201603346VA (en) * | 2013-11-08 | 2016-05-30 | Suzhou Osel Bio Pharm Co Ltd | Lactobacillus crispatus and application thereof |
| JP6823601B2 (ja) | 2015-10-30 | 2021-02-03 | 株式会社ヤクルト本社 | 微生物乾燥菌体の製造方法 |
| WO2019010282A1 (en) * | 2017-07-07 | 2019-01-10 | Osel, Inc. | STABILIZED FORMULATIONS WITH HIGH POWER OF LACTOBACILLUS VAGINAL |
-
2018
- 2018-07-05 WO PCT/US2018/040884 patent/WO2019010282A1/en not_active Ceased
- 2018-07-05 AU AU2018298117A patent/AU2018298117B2/en active Active
- 2018-07-05 CN CN201880045148.3A patent/CN110869036B/zh active Active
- 2018-07-05 US US16/627,118 patent/US20200171107A1/en not_active Abandoned
- 2018-07-05 JP JP2020521496A patent/JP7347760B2/ja active Active
- 2018-07-05 EP EP18827562.2A patent/EP3648778A4/en active Pending
-
2020
- 2020-03-20 US US16/825,225 patent/US11083761B2/en active Active
-
2021
- 2021-07-09 US US17/372,325 patent/US12303538B2/en active Active
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