JP2020526582A5 - - Google Patents
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- Publication number
- JP2020526582A5 JP2020526582A5 JP2020521495A JP2020521495A JP2020526582A5 JP 2020526582 A5 JP2020526582 A5 JP 2020526582A5 JP 2020521495 A JP2020521495 A JP 2020521495A JP 2020521495 A JP2020521495 A JP 2020521495A JP 2020526582 A5 JP2020526582 A5 JP 2020526582A5
- Authority
- JP
- Japan
- Prior art keywords
- lactobacillus
- composition
- species
- patient
- item
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 241000186660 Lactobacillus Species 0.000 claims description 23
- 230000003115 biocidal effect Effects 0.000 claims description 9
- 210000001161 mammalian embryo Anatomy 0.000 claims description 8
- 230000002159 abnormal effect Effects 0.000 claims description 7
- 241000218492 Lactobacillus crispatus Species 0.000 claims description 5
- 241000207201 Gardnerella vaginalis Species 0.000 claims description 4
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 claims description 4
- 241000186606 Lactobacillus gasseri Species 0.000 claims description 4
- 229940039696 lactobacillus Drugs 0.000 claims description 4
- 241000894007 species Species 0.000 claims description 4
- 241001633064 Atopobium vaginae Species 0.000 claims description 3
- 241000894006 Bacteria Species 0.000 claims description 3
- 208000004926 Bacterial Vaginosis Diseases 0.000 claims description 3
- 230000035935 pregnancy Effects 0.000 claims description 3
- 239000003242 anti bacterial agent Substances 0.000 claims description 2
- 229960002227 clindamycin Drugs 0.000 claims description 2
- KDLRVYVGXIQJDK-AWPVFWJPSA-N clindamycin Chemical compound CN1C[C@H](CCC)C[C@H]1C(=O)N[C@H]([C@H](C)Cl)[C@@H]1[C@H](O)[C@H](O)[C@@H](O)[C@@H](SC)O1 KDLRVYVGXIQJDK-AWPVFWJPSA-N 0.000 claims description 2
- 238000001514 detection method Methods 0.000 claims description 2
- 230000001605 fetal effect Effects 0.000 claims description 2
- 229960000282 metronidazole Drugs 0.000 claims description 2
- VAOCPAMSLUNLGC-UHFFFAOYSA-N metronidazole Chemical compound CC1=NC=C([N+]([O-])=O)N1CCO VAOCPAMSLUNLGC-UHFFFAOYSA-N 0.000 claims description 2
- 238000002604 ultrasonography Methods 0.000 claims description 2
- 241001561398 Lactobacillus jensenii Species 0.000 claims 1
- 210000002257 embryonic structure Anatomy 0.000 claims 1
- 230000009027 insemination Effects 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 238000000034 method Methods 0.000 description 18
- 208000037009 Vaginitis bacterial Diseases 0.000 description 2
- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 description 1
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 description 1
- HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000004720 fertilization Effects 0.000 description 1
- 210000002458 fetal heart Anatomy 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 230000013011 mating Effects 0.000 description 1
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 description 1
- 210000004877 mucosa Anatomy 0.000 description 1
- 235000010378 sodium ascorbate Nutrition 0.000 description 1
- PPASLZSBLFJQEF-RKJRWTFHSA-M sodium ascorbate Substances [Na+].OC[C@@H](O)[C@H]1OC(=O)C(O)=C1[O-] PPASLZSBLFJQEF-RKJRWTFHSA-M 0.000 description 1
- 229960005055 sodium ascorbate Drugs 0.000 description 1
- 239000001488 sodium phosphate Substances 0.000 description 1
- 229910000162 sodium phosphate Inorganic materials 0.000 description 1
- PPASLZSBLFJQEF-RXSVEWSESA-M sodium-L-ascorbate Chemical compound [Na+].OC[C@H](O)[C@H]1OC(=O)C(O)=C1[O-] PPASLZSBLFJQEF-RXSVEWSESA-M 0.000 description 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
- 239000000811 xylitol Substances 0.000 description 1
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
- 229960002675 xylitol Drugs 0.000 description 1
- 235000010447 xylitol Nutrition 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762529733P | 2017-07-07 | 2017-07-07 | |
| US62/529,733 | 2017-07-07 | ||
| PCT/US2018/040882 WO2019010281A1 (en) | 2017-07-07 | 2018-07-05 | USE OF VAGINAL LACTOBACILLES TO IMPROVE IN VITRO FERTILIZATION RATE OF SUCCESS |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2020526582A JP2020526582A (ja) | 2020-08-31 |
| JP2020526582A5 true JP2020526582A5 (https=) | 2021-07-29 |
Family
ID=64951221
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020521495A Pending JP2020526582A (ja) | 2017-07-07 | 2018-07-05 | 体外受精の成功率を向上させるための膣ラクトバチルスの使用 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US11278581B2 (https=) |
| EP (1) | EP3648779A4 (https=) |
| JP (1) | JP2020526582A (https=) |
| CN (1) | CN110831610A (https=) |
| AU (1) | AU2018298116A1 (https=) |
| CA (1) | CA3068974A1 (https=) |
| WO (1) | WO2019010281A1 (https=) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019010281A1 (en) * | 2017-07-07 | 2019-01-10 | Osel, Inc. | USE OF VAGINAL LACTOBACILLES TO IMPROVE IN VITRO FERTILIZATION RATE OF SUCCESS |
| WO2022175680A1 (en) * | 2021-02-19 | 2022-08-25 | Imperial College Innovations Limited | Lactobacillus crispatus composition for use in pregnant subjects |
| CN115181711B (zh) * | 2022-09-14 | 2022-12-13 | 中国农业科学院北京畜牧兽医研究所 | 人乳杆菌lhm11及菌剂和应用 |
| CN116804176B (zh) * | 2023-06-14 | 2024-07-02 | 善恩康生物科技（苏州）有限公司 | 一株阴道卷曲乳酸杆菌及其在制备防治慢性子宫内膜炎和由ce引起的女性不孕症的药物中的应用 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6093394A (en) | 1997-04-11 | 2000-07-25 | Gynelogix, Inc. | Vaginal lactobacillus medicant |
| CN1304313A (zh) * | 1998-06-05 | 2001-07-18 | 若素制药株式会社 | 含乳酸菌的组合物、药物和食物 |
| AU2007274081B2 (en) * | 2006-07-12 | 2012-08-02 | Controlled Therapeutics (Scotland) Ltd. | Drug delivery polymer with hydrochloride salt of clindamycin |
| WO2009079607A1 (en) * | 2007-12-18 | 2009-06-25 | Osel, Inc. | Applicator for applying powder formulations and uses thereof |
| US8329447B2 (en) * | 2008-12-12 | 2012-12-11 | Osel, Inc. | Strain of Lactobacillus crispatus |
| CN103911306B (zh) * | 2013-01-05 | 2016-08-24 | 欣力菲生物医药技术（天津）有限公司 | 加氏乳杆菌菌株及其用途 |
| US9937214B2 (en) * | 2013-11-08 | 2018-04-10 | Suzhou Osel Bio-Pharm Co., Ltd. | Lactobacillus crispatus and application thereof |
| CN104178437B (zh) * | 2013-11-08 | 2016-08-24 | 苏州欧赛微科生物医药科技有限公司 | 一种卷曲乳杆菌及其在妇科疾病中的应用 |
| EP3233098B1 (en) * | 2014-12-15 | 2024-05-29 | The Johns Hopkins University | Cvs transplantation for treatment of bacterial vaginosis |
| WO2018045359A1 (en) * | 2016-09-02 | 2018-03-08 | Karius, Inc. | Detection and treatment of infection during pregnancy |
| US20200171107A1 (en) * | 2017-07-07 | 2020-06-04 | Osel, Inc. | High potency stable formulations of vaginal lactobacillus |
| WO2019010281A1 (en) * | 2017-07-07 | 2019-01-10 | Osel, Inc. | USE OF VAGINAL LACTOBACILLES TO IMPROVE IN VITRO FERTILIZATION RATE OF SUCCESS |
| US10918663B2 (en) * | 2018-04-03 | 2021-02-16 | Reoxcyn, Llc | Compositions and methods for the treatment of bacterial vaginosis |
| EA202092443A1 (ru) * | 2018-05-22 | 2021-04-26 | Артпред Б.В. | Способ и набор для прогнозирования результата процедуры вспомогательных репродуктивных технологий |
| WO2020007780A1 (en) * | 2018-07-02 | 2020-01-09 | Artpred B.V. | Method and kit for altering the outcome of an assisted reproductive technology procedure |
| ES2980222T3 (es) * | 2018-08-30 | 2024-09-30 | Osel Inc | Bacteriocinas para mejorar la colonización vaginal de Lactobacillus productor de peróxido de hidrógeno para la salud de reproducción femenina |
-
2018
- 2018-07-05 WO PCT/US2018/040882 patent/WO2019010281A1/en not_active Ceased
- 2018-07-05 US US16/627,248 patent/US11278581B2/en not_active Expired - Fee Related
- 2018-07-05 EP EP18828806.2A patent/EP3648779A4/en not_active Withdrawn
- 2018-07-05 AU AU2018298116A patent/AU2018298116A1/en not_active Abandoned
- 2018-07-05 JP JP2020521495A patent/JP2020526582A/ja active Pending
- 2018-07-05 CA CA3068974A patent/CA3068974A1/en active Pending
- 2018-07-05 CN CN201880045144.5A patent/CN110831610A/zh active Pending
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