JP2020525167A5 - - Google Patents

Download PDF

Info

Publication number
JP2020525167A5
JP2020525167A5 JP2019571959A JP2019571959A JP2020525167A5 JP 2020525167 A5 JP2020525167 A5 JP 2020525167A5 JP 2019571959 A JP2019571959 A JP 2019571959A JP 2019571959 A JP2019571959 A JP 2019571959A JP 2020525167 A5 JP2020525167 A5 JP 2020525167A5
Authority
JP
Japan
Prior art keywords
target volume
tissue
target
therapeutic agent
map
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2019571959A
Other languages
English (en)
Japanese (ja)
Other versions
JP2020525167A (ja
JPWO2019002940A5 (enExample
Filing date
Publication date
Priority claimed from US15/637,163 external-priority patent/US11123575B2/en
Application filed filed Critical
Priority claimed from PCT/IB2018/000811 external-priority patent/WO2019002940A1/en
Publication of JP2020525167A publication Critical patent/JP2020525167A/ja
Publication of JP2020525167A5 publication Critical patent/JP2020525167A5/ja
Publication of JPWO2019002940A5 publication Critical patent/JPWO2019002940A5/ja
Pending legal-status Critical Current

Links

JP2019571959A 2017-06-29 2018-06-29 キャビテーション強化型の標的化薬物送達および投与 Pending JP2020525167A (ja)

Applications Claiming Priority (13)

Application Number Priority Date Filing Date Title
US201762526550P 2017-06-29 2017-06-29
US201762526545P 2017-06-29 2017-06-29
US201762526548P 2017-06-29 2017-06-29
US15/637,163 US11123575B2 (en) 2017-06-29 2017-06-29 3D conformal radiation therapy with reduced tissue stress and improved positional tolerance
US62/526,545 2017-06-29
US62/526,550 2017-06-29
US62/526,548 2017-06-29
US15/637,163 2017-06-29
US201762597076P 2017-12-11 2017-12-11
US201762597073P 2017-12-11 2017-12-11
US62/597,076 2017-12-11
US62/597,073 2017-12-11
PCT/IB2018/000811 WO2019002940A1 (en) 2017-06-29 2018-06-29 TARGETED ADMINISTRATION AND DETERMINATION ENHANCED BY CAVITATION OF A MEDICAMENT

Publications (3)

Publication Number Publication Date
JP2020525167A JP2020525167A (ja) 2020-08-27
JP2020525167A5 true JP2020525167A5 (enExample) 2021-07-26
JPWO2019002940A5 JPWO2019002940A5 (enExample) 2022-07-26

Family

ID=63364094

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2019571961A Active JP7289061B2 (ja) 2017-06-29 2018-06-29 シミュレーションベースの薬物処置計画
JP2019571960A Active JP7232204B2 (ja) 2017-06-29 2018-06-29 マイクロバブル強化超音波処置における超音波周波数およびマイクロバブルサイズの最適化
JP2019571959A Pending JP2020525167A (ja) 2017-06-29 2018-06-29 キャビテーション強化型の標的化薬物送達および投与

Family Applications Before (2)

Application Number Title Priority Date Filing Date
JP2019571961A Active JP7289061B2 (ja) 2017-06-29 2018-06-29 シミュレーションベースの薬物処置計画
JP2019571960A Active JP7232204B2 (ja) 2017-06-29 2018-06-29 マイクロバブル強化超音波処置における超音波周波数およびマイクロバブルサイズの最適化

Country Status (4)

Country Link
EP (3) EP3645116B1 (enExample)
JP (3) JP7289061B2 (enExample)
CN (3) CN111132732B (enExample)
WO (3) WO2019002940A1 (enExample)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11123575B2 (en) 2017-06-29 2021-09-21 Insightec, Ltd. 3D conformal radiation therapy with reduced tissue stress and improved positional tolerance
AU2019389001B2 (en) 2018-11-28 2025-08-14 Histosonics, Inc. Histotripsy systems and methods
US20220161013A1 (en) * 2019-04-04 2022-05-26 Northwestern University Improved delivery of drug therapy to the cns by ultrasound-based opening of the blood-brain barrier
US11730452B2 (en) * 2019-04-09 2023-08-22 Insightec Ltd. Systems and methods for regulating microbubbles in ultrasound procedures
US12409345B2 (en) 2019-07-25 2025-09-09 Insightec Ltd. Aberration corrections for dynamically changing media during ultrasound therapy
AU2021213168A1 (en) 2020-01-28 2022-09-01 The Regents Of The University Of Michigan Systems and methods for histotripsy immunosensitization
EP4114519A1 (en) 2020-03-05 2023-01-11 Insightec, Ltd. Differential prediction of aberration corrections for ultrasound therapy
IL300851A (en) 2020-08-27 2023-04-01 Univ Michigan Regents Ultrasonic transducer with transmit-receive capability for focused ultrasound
US20250263798A1 (en) 2021-07-01 2025-08-21 Insightec Ltd. Diagnostic and treatment monitoring based on blood-brain barrier disruption
CN113714070B (zh) * 2021-07-26 2022-05-24 中北大学 混合振膜结构宽频带电容式微机械超声换能器设计方法
EP4496618A2 (en) * 2022-03-22 2025-01-29 Insightec Ltd. Monitoring tissue permeability during ultrasound procedures
WO2024047580A1 (en) * 2022-08-31 2024-03-07 Insightec Ltd. Enforced tissue residency of payload molecules by acoustic disruption
AU2023366591A1 (en) 2022-10-28 2025-04-24 Histosonics, Inc. Histotripsy systems and methods
KR102626932B1 (ko) * 2023-01-03 2024-01-23 주식회사 뉴머스 환자 맞춤형 헬멧 및 이의 제조 방법
WO2024221001A2 (en) 2023-04-20 2024-10-24 Histosonics, Inc. Histotripsy systems and associated methods including user interfaces and workflows for treatment planning and therapy
WO2024257021A1 (en) * 2023-06-13 2024-12-19 Insightec Ltd. Tissue type-based blood-brain barrier opening and treatment parameter establishment systems thereof

Family Cites Families (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6369039B1 (en) 1998-06-30 2002-04-09 Scimed Life Sytems, Inc. High efficiency local drug delivery
US6309355B1 (en) * 1998-12-22 2001-10-30 The Regents Of The University Of Michigan Method and assembly for performing ultrasound surgery using cavitation
US7611462B2 (en) 2003-05-22 2009-11-03 Insightec-Image Guided Treatment Ltd. Acoustic beam forming in phased arrays including large numbers of transducer elements
CN101005858A (zh) * 2004-08-18 2007-07-25 伯拉考开发股份有限公司 用于反差成像的充气微泡组合物
TWI271202B (en) * 2004-11-12 2007-01-21 Ching-Hua Wang Formula for stimulating biological active substance entering skin or mucous membrane and the application of the same
CN100536783C (zh) * 2005-01-19 2009-09-09 微星科技股份有限公司 颅内压量测方法及系统
JP2006231304A (ja) * 2005-02-28 2006-09-07 Advance Alpha:Kk マイクロバブル発生方法およびマイクロバブル発生装置
JP4630127B2 (ja) * 2005-05-17 2011-02-09 株式会社日立製作所 超音波診断治療装置
EP1904179A2 (en) * 2005-06-07 2008-04-02 Koninklijke Philips Electronics N.V. Method and apparatus for ultrasound drug delivery and thermal therapy with phase-convertible fluids
US20070016039A1 (en) * 2005-06-21 2007-01-18 Insightec-Image Guided Treatment Ltd. Controlled, non-linear focused ultrasound treatment
JP4369907B2 (ja) * 2005-07-01 2009-11-25 株式会社日立製作所 音響化学治療装置
CN100386057C (zh) * 2005-10-31 2008-05-07 西安交通大学 基于包膜微泡的灌注成像与超声控制释放的系统和方法
US8548562B2 (en) * 2006-04-04 2013-10-01 John Trachtenberg System and method of guided treatment within malignant prostate tissue
WO2008137942A1 (en) * 2007-05-07 2008-11-13 Guided Therapy Systems, Llc. Methods and systems for modulating medicants using acoustic energy
CN101902971B (zh) * 2007-12-21 2013-03-13 皇家飞利浦电子股份有限公司 用于追踪和引导高强度聚焦超声波束的系统及方法
WO2010010473A1 (en) 2008-07-23 2010-01-28 Koninklijke Philips Electronics, N.V. Ultrasound mediated drug delivery
US9987505B2 (en) * 2008-08-20 2018-06-05 The Brigham And Women's Hospital, Inc. Method for modifying glomerular permeability and function with focused ultrasound
WO2010030819A1 (en) 2008-09-10 2010-03-18 The Trustees Of Columbia University In The City Of New York Systems and methods for opening a tissue
WO2010118307A1 (en) * 2009-04-09 2010-10-14 The Trustees Of The University Of Pennsylvania Methods and systems for image-guided treatment of blood vessels
US20120052469A1 (en) 2009-04-23 2012-03-01 Yeda Research And Development Co. Ltd. at the Weizmann Institute of Sience Nasal flow device controller
SG176103A1 (en) * 2009-05-25 2011-12-29 Merck Patent Gmbh Continuous administration of cilengitide in cancer treatments
EP2480144B1 (en) 2009-09-21 2024-03-06 The Trustees of Columbia University in the City of New York Systems for opening of a tissue barrier
KR101200249B1 (ko) * 2009-10-05 2012-11-09 한국전기연구원 경피 약물 전달 장치
CN101698121B (zh) * 2009-10-23 2011-06-22 西安交通大学 促进药物透过血脑屏障的适型超声系统
CN103180014B (zh) 2010-07-29 2016-12-28 因赛泰克有限公司 用于非侵入性的治疗疗法的移动补偿
GB201115419D0 (en) * 2011-09-07 2011-10-19 Univ Leuven Kath Non-invasive in-situ radiation dosimetry
CN103842020B (zh) * 2011-10-05 2016-12-28 皇家飞利浦有限公司 用于超声介导的递送的化验
US20130331738A1 (en) * 2012-06-11 2013-12-12 Board Of Trustees University Of Arkansas Compositions and methods for potentiating sonothrombolysis
KR101991263B1 (ko) * 2012-06-27 2019-06-21 제주대학교 산학협력단 초음파의 열 효과를 가시화하는 스마트 조직 팬텀
US8927761B2 (en) * 2012-06-28 2015-01-06 Photocure Asa Form of hexyl-5-aminolevulinate hydrochloride and methods of using the same
CA2878491A1 (en) * 2012-07-08 2014-01-16 Sunnybrook Health Sciences Centre System and method for using ultrasound-stimulated microbubble exposures to induce ceramide accumulation in endothelial and tumor cells
GB2505740A (en) * 2012-09-05 2014-03-12 Surf Technology As Instrument and method for ultrasound mediated drug delivery
RU2650598C2 (ru) 2012-10-12 2018-04-16 Профаунд Медикал Инк. Мультифокусные соникации для гипертермических лечебных воздействий с использованием ультразвука, сфокусированного под контролем магнитно-резонансной томографии
WO2014118632A1 (en) * 2013-01-29 2014-08-07 Insightec, Ltd. Simulation-based focused-ultrasound treatment planning
WO2014135987A2 (en) 2013-03-06 2014-09-12 Insightec, Ltd. Frequency optimization in ultrasound treatment
CN103417249B (zh) * 2013-07-15 2015-06-03 南京航空航天大学 一种超声检测与治疗一体化的内窥镜
CN105658243B (zh) * 2013-09-27 2019-11-08 菲尼克斯解决方案有限公司 超声介导的药物递送
CN103520831A (zh) * 2013-10-14 2014-01-22 南京航空航天大学 药液超声治疗循环系统
CN104146730A (zh) * 2014-08-18 2014-11-19 中国人民解放军第三军医大学第二附属医院 医用诊断超声波激励微泡调控双侧血脑屏障通透性的用途
CN107251028A (zh) * 2014-12-18 2017-10-13 弗雷塞尼斯医疗保健控股公司 进行计算机模拟临床试验的系统和方法
KR101657285B1 (ko) * 2015-05-13 2016-09-19 조선대학교산학협력단 초음파 치료 시뮬레이션시스템
US9934570B2 (en) 2015-10-09 2018-04-03 Insightec, Ltd. Systems and methods for registering images obtained using various imaging modalities and verifying image registration
US10475192B2 (en) 2016-06-10 2019-11-12 Insightec, Ltd. Motion tracking during non-invasive therapy

Similar Documents

Publication Publication Date Title
JP2020525167A5 (enExample)
JP2020525169A5 (enExample)
JP2020520718A5 (enExample)
JP2020525168A5 (enExample)
CN110831665B (zh) 用于破坏靶组织以进行治疗以及评估靶组织破坏的系统
Snipstad et al. Sonopermeation to improve drug delivery to tumors: from fundamental understanding to clinical translation
Jung et al. The efficacy and limits of magnetic resonance–guided focused ultrasound pallidotomy for Parkinson’s disease: a Phase I clinical trial
O’Reilly et al. Focused-ultrasound disruption of the blood-brain barrier using closely-timed short pulses: influence of sonication parameters and injection rate
US11918832B2 (en) Systems and methods for selective, targeted opening of the blood-brain barrier
Choi et al. Noninvasive and transient blood-brain barrier opening in the hippocampus of Alzheimer's double transgenic mice using focused ultrasound
JP2021505295A (ja) 微小気泡媒介超音波手技における外因性作用物質特性の制御
US20090005711A1 (en) Systems and methods for opening of the blood-brain barrier of a subject using ultrasound
Koh et al. Use of hyaluronidase as an adjuvant to ropivacaine to reduce axillary brachial plexus block onset time: a prospective, randomised controlled study
McDannold et al. Cavitation monitoring, treatment strategy, and acoustic simulations of focused ultrasound blood-brain barrier disruption in patients with glioblastoma
Korkmaz et al. Pulsed radiofrequency versus conventional transcutaneous electrical nerve stimulation in painful shoulder: a prospective, randomized study
JPWO2019002940A5 (enExample)
JP7483694B2 (ja) 神経調節技術
Bernardi et al. Applicability of ARFI elastography in detecting elasticity changes of the equine superficial digital flexor tendon with induced injury
Succop Jr et al. Focused Ultrasound in the Treatment of Epilepsy: Current Applications and Future Directions
Agopyan-Miu et al. Is there a role for focused ultrasound in the treatment of refractory epilepsy?
CN119896532B (zh) 一种声动力治疗脑胶质瘤的装置
Chattenton Drug delivery across the blood-brain barrier using short-pulse focused ultrasound and microbubbles for the treatment of diffuse intrinsic pontine glioma
US20240131362A1 (en) Simulation-Based Drug Treatment Planning
Karlsson et al. The impact of activating source dwell positions outside the CTV on the dose to treated normal tissue volumes in TRUS guided 3D conformal interstitial HDR brachytherapy of prostate cancer
McMahon et al. Biophysical and Clinical Perspectives on Blood-Brain Barrier Permeability Enhancement by Ultrasound and Microbubbles for Targeted Drug Delivery