JP2020524524A5 - - Google Patents
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- Publication number
- JP2020524524A5 JP2020524524A5 JP2020516379A JP2020516379A JP2020524524A5 JP 2020524524 A5 JP2020524524 A5 JP 2020524524A5 JP 2020516379 A JP2020516379 A JP 2020516379A JP 2020516379 A JP2020516379 A JP 2020516379A JP 2020524524 A5 JP2020524524 A5 JP 2020524524A5
- Authority
- JP
- Japan
- Prior art keywords
- cflar
- hla
- expression level
- melanoma
- normalized
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 238000000034 method Methods 0.000 claims 25
- -1 CFLAR-AS1 Proteins 0.000 claims 22
- 201000001441 melanoma Diseases 0.000 claims 15
- 239000000090 biomarker Substances 0.000 claims 14
- JPKJQBJPBRLVTM-OSLIGDBKSA-N (2s)-2-amino-n-[(2s,3r)-3-hydroxy-1-[[(2s)-1-[[(2s)-1-[[(2s)-1-[[(2r)-1-(1h-indol-3-yl)-3-oxopropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-1-oxobutan-2-yl]-6-iminohexanamide Chemical compound C([C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)CCCC=N)[C@H](O)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@H](CC=1C2=CC=CC=C2NC=1)C=O)C1=CC=CC=C1 JPKJQBJPBRLVTM-OSLIGDBKSA-N 0.000 claims 11
- 102100038263 ATP-dependent RNA helicase DDX55 Human genes 0.000 claims 11
- 102100027766 Atlastin-1 Human genes 0.000 claims 11
- 102100025752 CASP8 and FADD-like apoptosis regulator Human genes 0.000 claims 11
- 102100031277 Calcineurin B homologous protein 1 Human genes 0.000 claims 11
- 241000839426 Chlamydia virus Chp1 Species 0.000 claims 11
- 102100022845 DnaJ homolog subfamily C member 9 Human genes 0.000 claims 11
- 102100024108 Dystrophin Human genes 0.000 claims 11
- 102000052930 Fanconi Anemia Complementation Group L protein Human genes 0.000 claims 11
- 108700026162 Fanconi Anemia Complementation Group L protein Proteins 0.000 claims 11
- 102100031547 HLA class II histocompatibility antigen, DO alpha chain Human genes 0.000 claims 11
- 102100022107 Holliday junction recognition protein Human genes 0.000 claims 11
- 101000883820 Homo sapiens ATP-dependent RNA helicase DDX55 Proteins 0.000 claims 11
- 101000936983 Homo sapiens Atlastin-1 Proteins 0.000 claims 11
- 101000914211 Homo sapiens CASP8 and FADD-like apoptosis regulator Proteins 0.000 claims 11
- 101000777252 Homo sapiens Calcineurin B homologous protein 1 Proteins 0.000 claims 11
- 101000943802 Homo sapiens Cysteine and histidine-rich domain-containing protein 1 Proteins 0.000 claims 11
- 101000903036 Homo sapiens DnaJ homolog subfamily C member 9 Proteins 0.000 claims 11
- 101001053946 Homo sapiens Dystrophin Proteins 0.000 claims 11
- 101100119754 Homo sapiens FANCL gene Proteins 0.000 claims 11
- 101000866278 Homo sapiens HLA class II histocompatibility antigen, DO alpha chain Proteins 0.000 claims 11
- 101001045907 Homo sapiens Holliday junction recognition protein Proteins 0.000 claims 11
- 101000852980 Homo sapiens Interleukin-23 subunit alpha Proteins 0.000 claims 11
- 101000877521 Homo sapiens Mitochondrial enolase superfamily member 1 Proteins 0.000 claims 11
- 108010050332 IQ motif containing GTPase activating protein 1 Proteins 0.000 claims 11
- 102100036705 Interleukin-23 subunit alpha Human genes 0.000 claims 11
- 102100035387 Mitochondrial enolase superfamily member 1 Human genes 0.000 claims 11
- 102100034419 Ras GTPase-activating-like protein IQGAP1 Human genes 0.000 claims 11
- 101001053942 Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) Diphosphomevalonate decarboxylase Proteins 0.000 claims 11
- 102100040505 HLA class II histocompatibility antigen, DR alpha chain Human genes 0.000 claims 10
- 108010067802 HLA-DR alpha-Chains Proteins 0.000 claims 10
- 101000880116 Homo sapiens SERTA domain-containing protein 2 Proteins 0.000 claims 10
- 102100037351 SERTA domain-containing protein 2 Human genes 0.000 claims 10
- 108091006912 SLC35G5 Proteins 0.000 claims 10
- 102100032019 Solute carrier family 35 member G5 Human genes 0.000 claims 10
- 239000000523 sample Substances 0.000 claims 10
- 101000828739 Homo sapiens SPATS2-like protein Proteins 0.000 claims 8
- 102100023521 SPATS2-like protein Human genes 0.000 claims 8
- 101000613207 Homo sapiens Pre-B-cell leukemia transcription factor-interacting protein 1 Proteins 0.000 claims 7
- 102100040882 Pre-B-cell leukemia transcription factor-interacting protein 1 Human genes 0.000 claims 7
- 238000002560 therapeutic procedure Methods 0.000 claims 7
- 108700039887 Essential Genes Proteins 0.000 claims 6
- 101000940146 Homo sapiens Transcription factor YY2 Proteins 0.000 claims 5
- 101000713936 Homo sapiens Tudor domain-containing protein 7 Proteins 0.000 claims 5
- 101000606067 Homo sapiens Tyrosine-protein kinase TXK Proteins 0.000 claims 5
- 102100031148 Transcription factor YY2 Human genes 0.000 claims 5
- 102100036455 Tudor domain-containing protein 7 Human genes 0.000 claims 5
- 102100039079 Tyrosine-protein kinase TXK Human genes 0.000 claims 5
- 101001107084 Homo sapiens E3 ubiquitin-protein ligase RNF5 Proteins 0.000 claims 4
- 102000056817 RNF5 Human genes 0.000 claims 4
- 239000003795 chemical substances by application Substances 0.000 claims 4
- 239000002299 complementary DNA Substances 0.000 claims 4
- 238000002271 resection Methods 0.000 claims 4
- 101000762938 Homo sapiens TOX high mobility group box family member 4 Proteins 0.000 claims 3
- 101000653679 Homo sapiens Translationally-controlled tumor protein Proteins 0.000 claims 3
- ZBZXYUYUUDZCNB-UHFFFAOYSA-N N-cyclohexa-1,3-dien-1-yl-N-phenyl-4-[4-(N-[4-[4-(N-[4-[4-(N-phenylanilino)phenyl]phenyl]anilino)phenyl]phenyl]anilino)phenyl]aniline Chemical compound C1=CCCC(N(C=2C=CC=CC=2)C=2C=CC(=CC=2)C=2C=CC(=CC=2)N(C=2C=CC=CC=2)C=2C=CC(=CC=2)C=2C=CC(=CC=2)N(C=2C=CC=CC=2)C=2C=CC(=CC=2)C=2C=CC(=CC=2)N(C=2C=CC=CC=2)C=2C=CC=CC=2)=C1 ZBZXYUYUUDZCNB-UHFFFAOYSA-N 0.000 claims 3
- 102100026749 TOX high mobility group box family member 4 Human genes 0.000 claims 3
- 102100029887 Translationally-controlled tumor protein Human genes 0.000 claims 3
- 101150022630 prp5 gene Proteins 0.000 claims 3
- 101000629622 Homo sapiens Serine-pyruvate aminotransferase Proteins 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 102100026842 Serine-pyruvate aminotransferase Human genes 0.000 claims 2
- 210000004369 blood Anatomy 0.000 claims 2
- 239000008280 blood Substances 0.000 claims 2
- 238000001514 detection method Methods 0.000 claims 2
- 239000007850 fluorescent dye Substances 0.000 claims 2
- 210000002381 plasma Anatomy 0.000 claims 2
- 210000002966 serum Anatomy 0.000 claims 2
- 238000002626 targeted therapy Methods 0.000 claims 2
- 102100027831 14-3-3 protein theta Human genes 0.000 claims 1
- 102100040685 14-3-3 protein zeta/delta Human genes 0.000 claims 1
- 102100029511 26S proteasome regulatory subunit 6B Human genes 0.000 claims 1
- 102100028104 39S ribosomal protein L19, mitochondrial Human genes 0.000 claims 1
- 102100040881 60S acidic ribosomal protein P0 Human genes 0.000 claims 1
- 102100022289 60S ribosomal protein L13a Human genes 0.000 claims 1
- 102100026611 Alpha-1,2-mannosyltransferase ALG9 Human genes 0.000 claims 1
- 229940125431 BRAF inhibitor Drugs 0.000 claims 1
- 102100027314 Beta-2-microglobulin Human genes 0.000 claims 1
- 102100026031 Beta-glucuronidase Human genes 0.000 claims 1
- 101100421140 Danio rerio selenon gene Proteins 0.000 claims 1
- 101000723543 Homo sapiens 14-3-3 protein theta Proteins 0.000 claims 1
- 101000964898 Homo sapiens 14-3-3 protein zeta/delta Proteins 0.000 claims 1
- 101001125524 Homo sapiens 26S proteasome regulatory subunit 6B Proteins 0.000 claims 1
- 101001079803 Homo sapiens 39S ribosomal protein L19, mitochondrial Proteins 0.000 claims 1
- 101000673456 Homo sapiens 60S acidic ribosomal protein P0 Proteins 0.000 claims 1
- 101000681240 Homo sapiens 60S ribosomal protein L13a Proteins 0.000 claims 1
- 101000756632 Homo sapiens Actin, cytoplasmic 1 Proteins 0.000 claims 1
- 101000717828 Homo sapiens Alpha-1,2-mannosyltransferase ALG9 Proteins 0.000 claims 1
- 101000937544 Homo sapiens Beta-2-microglobulin Proteins 0.000 claims 1
- 101000933465 Homo sapiens Beta-glucuronidase Proteins 0.000 claims 1
- 101000896557 Homo sapiens Eukaryotic translation initiation factor 3 subunit B Proteins 0.000 claims 1
- 101000988834 Homo sapiens Hypoxanthine-guanine phosphoribosyltransferase Proteins 0.000 claims 1
- 101000969546 Homo sapiens Mortality factor 4-like protein 1 Proteins 0.000 claims 1
- 101001111252 Homo sapiens NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial Proteins 0.000 claims 1
- 101001109052 Homo sapiens NADH-ubiquinone oxidoreductase chain 4 Proteins 0.000 claims 1
- 101001068630 Homo sapiens Protein PRRC2B Proteins 0.000 claims 1
- 101000863956 Homo sapiens Protein dopey-2 Proteins 0.000 claims 1
- 101000616974 Homo sapiens Pumilio homolog 1 Proteins 0.000 claims 1
- 101000707546 Homo sapiens Splicing factor 3A subunit 1 Proteins 0.000 claims 1
- 101000685323 Homo sapiens Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial Proteins 0.000 claims 1
- 101000835093 Homo sapiens Transferrin receptor protein 1 Proteins 0.000 claims 1
- 102100029098 Hypoxanthine-guanine phosphoribosyltransferase Human genes 0.000 claims 1
- 102100021395 Mortality factor 4-like protein 1 Human genes 0.000 claims 1
- 102100023955 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial Human genes 0.000 claims 1
- 102100021506 NADH-ubiquinone oxidoreductase chain 4 Human genes 0.000 claims 1
- 102100033953 Protein PRRC2B Human genes 0.000 claims 1
- 102100029929 Protein dopey-2 Human genes 0.000 claims 1
- 102100021672 Pumilio homolog 1 Human genes 0.000 claims 1
- 102100031713 Splicing factor 3A subunit 1 Human genes 0.000 claims 1
- 102100023155 Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial Human genes 0.000 claims 1
- 102100026144 Transferrin receptor protein 1 Human genes 0.000 claims 1
- 101710075829 VPS37A Proteins 0.000 claims 1
- 102100034324 Vacuolar protein sorting-associated protein 37A Human genes 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 108020004445 glyceraldehyde-3-phosphate dehydrogenase Proteins 0.000 claims 1
- 102000006602 glyceraldehyde-3-phosphate dehydrogenase Human genes 0.000 claims 1
- 238000009169 immunotherapy Methods 0.000 claims 1
- 230000001613 neoplastic effect Effects 0.000 claims 1
- 108020004707 nucleic acids Proteins 0.000 claims 1
- 150000007523 nucleic acids Chemical class 0.000 claims 1
- 102000039446 nucleic acids Human genes 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
- 230000000750 progressive effect Effects 0.000 claims 1
- 239000013074 reference sample Substances 0.000 claims 1
- 230000035945 sensitivity Effects 0.000 claims 1
- 208000024891 symptom Diseases 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762511058P | 2017-05-25 | 2017-05-25 | |
| US62/511,058 | 2017-05-25 | ||
| PCT/US2018/033658 WO2018217627A1 (en) | 2017-05-25 | 2018-05-21 | Methods for melanoma detection |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020524524A JP2020524524A (ja) | 2020-08-20 |
| JP2020524524A5 true JP2020524524A5 (enExample) | 2021-07-26 |
| JP7227964B2 JP7227964B2 (ja) | 2023-02-22 |
Family
ID=62620988
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020516379A Active JP7227964B2 (ja) | 2017-05-25 | 2018-05-21 | 黒色腫の検出方法 |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US20180340934A1 (enExample) |
| EP (1) | EP3631017B1 (enExample) |
| JP (1) | JP7227964B2 (enExample) |
| KR (1) | KR102763004B1 (enExample) |
| CN (1) | CN111315897B (enExample) |
| AU (1) | AU2018273844B2 (enExample) |
| BR (1) | BR112019024481A2 (enExample) |
| CA (1) | CA3064732A1 (enExample) |
| DK (1) | DK3631017T3 (enExample) |
| ES (1) | ES2920288T3 (enExample) |
| IL (1) | IL270787B2 (enExample) |
| MX (1) | MX2019014026A (enExample) |
| PL (1) | PL3631017T3 (enExample) |
| WO (1) | WO2018217627A1 (enExample) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR112019024481A2 (pt) | 2017-05-25 | 2020-07-14 | Liquid Biopsy Research LLC | métodos para detecção de melanoma |
| US20210108259A1 (en) | 2019-10-10 | 2021-04-15 | Liquid Biopsy Research LLC | Compositions, methods and kits for biological sample and rna stabilization |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2614946A1 (en) * | 2005-01-07 | 2006-07-13 | The Johns Hopkins University | Biomarkers for melanoma |
| US7615349B2 (en) * | 2006-09-07 | 2009-11-10 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Melanoma gene signature |
| EP2080140B1 (en) * | 2006-11-03 | 2013-04-24 | Baylor Research Institute | Diagnosis of metastatic melanoma and monitoring indicators of immunosuppression through blood leukocyte microarray analysis |
| EP2092075A2 (en) * | 2006-11-06 | 2009-08-26 | Source Precision Medicine, Inc. | Gene expression profiling for identification, monitoring and treatment of melanoma |
| US20110070582A1 (en) * | 2008-11-03 | 2011-03-24 | Source Precision Medicine, Inc. d/b/d Source MDX | Gene Expression Profiling for Predicting the Response to Immunotherapy and/or the Survivability of Melanoma Subjects |
| US20110091384A1 (en) * | 2009-10-13 | 2011-04-21 | The Johns Hopkins University | Biomarker for identification of melanoma tumor cells |
| US20140045915A1 (en) * | 2010-08-31 | 2014-02-13 | The General Hospital Corporation | Cancer-related biological materials in microvesicles |
| CN104470920A (zh) * | 2012-07-03 | 2015-03-25 | 通益制药有限公司 | 固态形式的维罗菲尼胆碱盐 |
| AU2015317893B2 (en) * | 2014-09-15 | 2021-05-20 | Clifton Life Sciences LLC | Compositions, methods and kits for diagnosis of a gastroenteropancreatic neuroendocrine neoplasm |
| BR112019024481A2 (pt) | 2017-05-25 | 2020-07-14 | Liquid Biopsy Research LLC | métodos para detecção de melanoma |
-
2018
- 2018-05-21 BR BR112019024481-6A patent/BR112019024481A2/pt unknown
- 2018-05-21 CN CN201880049298.1A patent/CN111315897B/zh active Active
- 2018-05-21 JP JP2020516379A patent/JP7227964B2/ja active Active
- 2018-05-21 MX MX2019014026A patent/MX2019014026A/es unknown
- 2018-05-21 EP EP18731615.3A patent/EP3631017B1/en active Active
- 2018-05-21 KR KR1020197038285A patent/KR102763004B1/ko active Active
- 2018-05-21 CA CA3064732A patent/CA3064732A1/en active Pending
- 2018-05-21 ES ES18731615T patent/ES2920288T3/es active Active
- 2018-05-21 WO PCT/US2018/033658 patent/WO2018217627A1/en not_active Ceased
- 2018-05-21 US US15/984,935 patent/US20180340934A1/en not_active Abandoned
- 2018-05-21 PL PL18731615.3T patent/PL3631017T3/pl unknown
- 2018-05-21 AU AU2018273844A patent/AU2018273844B2/en active Active
- 2018-05-21 DK DK18731615.3T patent/DK3631017T3/da active
-
2019
- 2019-11-20 IL IL270787A patent/IL270787B2/en unknown
-
2021
- 2021-09-30 US US17/490,433 patent/US12399179B2/en active Active
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