US20180340934A1 - Methods for melanoma detection - Google Patents

Methods for melanoma detection Download PDF

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US20180340934A1
US20180340934A1 US15/984,935 US201815984935A US2018340934A1 US 20180340934 A1 US20180340934 A1 US 20180340934A1 US 201815984935 A US201815984935 A US 201815984935A US 2018340934 A1 US2018340934 A1 US 2018340934A1
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expression level
cflar
hla
melanoma
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Irvin Mark Modlin
Mark Kidd
Ignat Drozdov
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Liquid Biopsy Research LLC
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Assigned to Liquid Biopsy Research LLC reassignment Liquid Biopsy Research LLC ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: DROZDOV, IGNAT, KIDD, MARK, MODLIN, Irvin Mark
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407—Specifically defined cancers
    • G01N33/5743—Specifically defined cancers of skin, e.g. melanoma
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    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/5308—Immunoassay; Biospecific binding assay; Materials therefor for analytes not provided for elsewhere, e.g. nucleic acids, uric acid, worms, mites
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
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    • C12Q2563/00—Nucleic acid detection characterized by the use of physical, structural and functional properties
    • C12Q2563/107—Nucleic acid detection characterized by the use of physical, structural and functional properties fluorescence
    • C—CHEMISTRY; METALLURGY
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    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/118—Prognosis of disease development
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
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    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
    • G—PHYSICS
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    • G01N2800/56—Staging of a disease; Further complications associated with the disease
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/60—Complex ways of combining multiple protein biomarkers for diagnosis
    • G—PHYSICS
    • G01—MEASURING; TESTING
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    • G01N2800/70—Mechanisms involved in disease identification
    • G01N2800/7023—(Hyper)proliferation
    • G01N2800/7028—Cancer

Definitions

  • the present invention relates to melanoma detection.
  • Melanoma is a common ( ⁇ 24-35/100,000 incidence—US), highly aggressive, skin cancer with an incidence that continues to rise. The most common, cutaneous melanomas, are associated with UV exposure and immune dysregulation. As a group, melanoma is known to carry the highest mutational burden (>10 mutations/Mb). Major mutations include BRAF ( ⁇ 50%), N-Ras ( ⁇ 20%) and NF-1 ( ⁇ 5%), which together, comprise 75% of all mutations. Melanomas are addicted to MAPK pathway activation, regardless of whether tumors exhibit mutations in genes coding for proteins in this pathway. This provides the rationale for targeted therapy e.g., BRAF v600E agents, in this tumor.
  • gain-of-function and loss-of-function mutations e.g., in RASopathy genes and amplification of cyclin D1/cdk4 and/or mutation/loss of the tumor suppressor PTEN, also characterize the tumor. This makes melanoma one of the most aggressive and therapy-resistant cancers.
  • Blood-based factors include lactate dehydrogenase (LDH), detecting mutations in circulating tumor (ct) DNA, measurements of circulating tumor cells (CTCs) and circulating mRNA.
  • LDH lactate dehydrogenase
  • CTCs circulating tumor cells
  • mRNA Circulating microNAs
  • a 28-gene expression tool for melanoma has high sensitivity and specificity (>95%) for the detection of melanoma and can differentiate aggressive untreated disease from stable, treated disease.
  • One aspect of the present disclosure relates to a method for detecting a melanoma in a subject in need thereof, comprising: (1) determining the expression level of at least 29 biomarkers from a test sample from the subject by contacting the test sample with a plurality of agents specific to detect the expression of the at least 29 biomarkers, wherein the at least 29 biomarkers comprise ATL1, ATP6V0D, C1ORF21, CFLAR, CFLAR-AS1, CHP1, DDX55, DMD, DNAJC9, ENOSF1, FANCL, HJURP, HLA-DOA, HLA-DRA, HNRNPA3P1, IL23A, IQGAP1, LOC494127, LOC646471, LOH12CR, PBXIP1, RNF5, SERTAD2, SLC35G5, SPATS2L, TDRD7, TXK, YY2, and at least one housekeeping gene; (2) normalizing the expression level of each of ATL1, ATP6V0D, C
  • the method further comprises treating the subject identified as having a melanoma with surgery or drug therapy.
  • Another aspect of the present disclosure relates to a method for determining whether a melanoma in a subject is stable or progressive, comprising: (1) determining the expression level of at least 29 biomarkers from a test sample from the subject by contacting the test sample with a plurality of agents specific to detect the expression of the at least 29 biomarkers, wherein the at least 29 biomarkers comprise ATL1, ATP6V0D, C1ORF21, CFLAR, CFLAR-AS1, CHP1, DDX55, DMD, DNAJC9, ENOSF1, FANCL, HJURP, HLA-DOA, HLA-DRA, HNRNPA3P1, IL23A, IQGAP1, LOC494127, LOC646471, LOH12CR, PBXIP1, RNF5, SERTAD2, SLC35G5, SPATS2L, TDRD7, TXK, YY2, and at least one housekeeping gene; (2) normalizing the expression level of each of ATL1, ATP6V0D
  • Another aspect of the present disclosure relates to a method for evaluating the extent of surgical resection in a subject having a melanoma, comprising: (1) determining the expression level of at least 29 biomarkers from a test sample from the subject after the surgical resection by contacting the test sample with a plurality of agents specific to detect the expression of the at least 29 biomarkers, wherein the at least 29 biomarkers comprise ATL1, ATP6V0D, C1ORF21, CFLAR, CFLAR-AS1, CHP1, DDX55, DMD, DNAJC9, ENOSF1, FANCL, HJURP, HLA-DOA, HLA-DRA, HNRNPA3P1, IL23A, IQGAP1, LOC494127, LOC646471, LOH12CR, PBXIP1, RNF5, SERTAD2, SLC35G5, SPATS2L, TDRD7, TXK, YY2, and at least one housekeeping gene; (2) normalizing the expression level of each of
  • the report further identifies that the risk of melanoma recurrence is high when the normalized expression level is equal to or greater than the third predetermined cutoff value or identifies that the risk of melanoma recurrence is low when the normalized expression level is below the third predetermined cutoff value.
  • Yet another aspect of the present disclosure relates to a method for determining a response by a subject having a melanoma to a therapy, comprising: (1) determining a first expression level of at least 28 biomarkers from a first test sample from the subject at a first time point by contacting the first test sample with a plurality of agents specific to detect the expression of the at least 28 biomarkers, wherein the 28 biomarkers comprise ATL1, ATP6V0D, C1ORF21, CFLAR, CFLAR-AS1, CHP1, DDX55, DMD, DNAJC9, ENOSF1, FANCL, HJURP, HLA-DOA, HLA-DRA, HNRNPA3P1, IL23A, IQGAP1, LOC494127, LOC646471, LOH12CR, PBXIP1, RNF5, SERTAD2, SLC35G5, SPATS2L, TDRD7, TXK, and YY2; (2) determining a second expression level of the at least
  • the first time point is prior to the administration of the therapy to the subject. In some embodiments, the first time point is after the administration of the therapy to the subject.
  • the therapy comprises an immunotherapy or a targeted therapy (e.g., a BRAF inhibitor).
  • the at least one housekeeping gene is selected from the group consisting of ALG9, SEPN, YWHAQ, VPS37A, PRRC2B, DOPEY2, NDUFB11, ND4, MRPL19, PSMC4, SF3A1, PUM1, ACTB, GAPD, GUSB, RPLPO, TFRC, MORF4L1, 18S, PPIA, PGK1, RPL13A, B2M, YWHAZ, SDHA, HPRT1, TOX4, and TPT1.
  • the at least one housekeeping gene comprises TOX4 and TPT1.
  • the normalized expression level is obtained by: (1) normalizing the expression level of each of ATL1, ATP6V0D, C1ORF21, CFLAR, CFLAR-AS1, CHP1, DDX55, DMD, DNAJC9, ENOSF1, FANCL, HJURP, HLA-DOA, HLA-DRA, HNRNPA3P1, IL23A, IQGAP1, LOC494127, LOC646471, LOH12CR, PBXIP1, RNF5, SERTAD2, SLC35G5, SPATS2L, TDRD7, TXK, and YY2 to the expression level of TOX4, thereby obtaining a first normalized expression level of each of ATL1, ATP6V0D, C1ORF21, CFLAR, CFLAR-AS1, CHP1, DDX55, DMD, DNAJC9, ENOSF1, FANCL, HJURP, HLA-DOA, HLA-DRA, HNRNPA3P1,
  • the method can have a specificity, sensitivity, and/or accuracy of at least 75%, 80%, 85%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, or 99%. In some embodiments, the method has a sensitivity of greater than 90%. In some embodiments, the method has a specificity of greater than 90%.
  • the biomarker is RNA, cDNA, or protein.
  • the RNA can be reverse transcribed to produce cDNA, and the produced cDNA expression level is detected.
  • the expression level of the biomarker is detected by forming a complex between the biomarker and a labeled probe or primer.
  • the biomarker is RNA or cDNA
  • the RNA or cDNA can be detected by forming a complex between the RNA or cDNA and a labeled nucleic acid probe or primer.
  • the biomarker is protein
  • the protein can be detected by forming a complex between the protein and a labeled antibody.
  • the label is a fluorescent label.
  • the test sample is blood, serum, plasma, or neoplastic tissue.
  • the first predetermined cutoff value can be derived from a plurality of reference samples obtained from subjects free of a neoplastic disease.
  • the second predetermined cutoff value can be derived from a plurality of reference samples obtained from subjects whose melanomas are being adequately controlled by therapies like immune therapy.
  • the third predetermined cutoff value can be derived from a plurality of reference samples obtained from subjects whose melanomas have been completely removed by surgery and they are considered “disease free.”
  • each reference sample can be blood, serum, plasma, or non-neoplastic tissue.
  • the subject in need thereof is a subject diagnosed with a melanoma, a subject having at least one melanoma symptom, or a subject having a predisposition or familial history for developing a melanoma.
  • the subject is a human.
  • the algorithm is XGB, RF, glmnet, cforest, CART, treebag, knn, nnet, SVM-radial, SVM-linear, NB, NNET, or mlp.
  • FIG. 1 is a graph showing visualization of the melanoma score as a system of three contributors to the clinical picture—Control, Response, and Progression. Samples towards each of the corner represent pure representations of each clinical group. Samples in the middle are in the area of both algorithmic and clinical uncertainty.
  • FIG. 2 is a graph showing the metrics for the test in the test set ranged from 87-100%.
  • FIGS. 3A-3C are a set of graphs showing the evaluation of the circulating melanoma gene test (Melanomx) in test set 2. Values were significantly higher in melanoma samples than in controls ( FIG. 3A ). Patients who were responding to therapy had values similar to controls. Receiver operator curve analysis of test set 2 identifying the AUC for differentiating melanoma from controls was >0.95 ( FIG. 3B ). The metrics for the test ranged from 78-92% ( FIG. 3C ).
  • FIG. 5 is a graph showing the effect of therapy on the Melanomx score. Levels were significantly decreased by immunotherapy (ipilimumab) or a BRAF inhibitor (Vemurafenib).
  • FIGS. 6A-6B are a set of graphs showing Melanomx score in 3 different melanoma cell lines.
  • FIG. 6A identifies the cell lines demonstrate elevated expression—Melanomx score ranging from 40 (A375) to 95 (Hs294).
  • FIG. 6B identifies that spiking these cells into blood from a subject that does not have a melanoma, resulted in detectable gene expression and scores. A minimum of 1 cell/ml of blood could be consistently identified.
  • FIGS. 7A-7B are a set of graphs showing expression in tumor tissue and its correlation with blood samples collected at the same time.
  • the Melanomx score ranged 40-97 in melanoma tumor tissue.
  • normal epithelium exhibited values ⁇ 20.
  • FIG. 7B gene expression in tumor tissue is compared to matched blood samples. This is highly concordant (correlation ⁇ 0.80).
  • melanoma Early signs of melanoma include changes to the shape or color of existing moles or, in the case of nodular melanoma, the appearance of a new lump anywhere on the skin. At later stages, the mole may itch, ulcerate or bleed. Visual inspection is the most common diagnostic technique.
  • Melanoma can be divided into the following types: lentigo maligna, lentigo maligna melanoma, superficial spreading melanoma, acral lentiginous melanoma, mucosal melanoma, nodular melanoma, polypoid melanoma, and desmoplastic melanoma.
  • RNA can be isolated from the peripheral blood of patients with melanoma. This expression profile is evaluated in an algorithm and converted to an output (prediction). It can identify active disease, provide an assessment of treatment responses, or predict risk of relapse, in conjunction with standard clinical assessment and imaging.
  • the present disclosure provides a method for detecting a melanoma in a subject in need thereof, including: (1) determining the expression level of at least 29 biomarkers from a test sample from the subject by contacting the test sample with a plurality of agents specific to detect the expression of the at least 29 biomarkers, wherein the at least 29 biomarkers comprise ATL1, ATP6V0D, C1ORF21, CFLAR, CFLAR-AS1, CHP1, DDX55, DMD, DNAJC9, ENOSF1, FANCL, HJURP, HLA-DOA, HLA-DRA, HNRNPA3P1, IL23A, IQGAP1, LOC494127, LOC646471, LOH12CR, PBXIP1, RNF5, SERTAD2, SLC35G5, SPATS2L, TDRD7, TXK, YY2, and at least one housekeeping gene; (2) normalizing the expression level of each of ATL1, ATP6V0D, C1ORF
  • the at least one housekeeping gene is selected from the group consisting of ALG9, SEPN, YWHAQ, VPS37A, PRRC2B, DOPEY2, NDUFB11, ND4, MRPL19, PSMC4, SF3A1, PUM1, ACTB, GAPD, GUSB, RPLPO, TFRC, MORF4L1, 18S, PPIA, PGK1, RPL13A, B2M, YWHAZ, SDHA, HPRT1, TOX4, and TPT1.
  • the at least one housekeeping gene comprises TOX4 and TPT1.
  • the normalized expression level is obtained by: (1) normalizing the expression level of each of ATL1, ATP6V0D, C1ORF21, CFLAR, CFLAR-AS1, CHP1, DDX55, DMD, DNAJC9, ENOSF1, FANCL, HJURP, HLA-DOA, HLA-DRA, HNRNPA3P1, IL23A, IQGAP1, LOC494127, LOC646471, LOH12CR, PBXIP1, RNF5, SERTAD2, SLC35G5, SPATS2L, TDRD7, TXK, and YY2 to the expression level of TOX4, thereby obtaining a first normalized expression level of each of ATL1, ATP6V0D, C1ORF21, CFLAR, CFLAR-AS1, CHP1, DDX55, DMD, DNAJC9, ENOSF1, FANCL, HJURP,
  • the provided methods are those that are able to classify or detect a melanoma.
  • the provided methods can identify or classify a melanoma in a human blood sample.
  • the methods can provide such information with a specificity, sensitivity, and/or accuracy of at least 75%, 80%, 85%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, or 99%.
  • the agents can be any agents for detection of the biomarkers, and typically are isolated polynucleotides or isolated polypeptides or proteins, such as antibodies, for example, those that specifically hybridize to or bind to the at least 29 biomarkers.
  • the biomarker can be RNA, cDNA, or protein.
  • the RNA can be reverse transcribed to produce cDNA (such as by RT-PCR), and the produced cDNA expression level is detected.
  • the expression level of the biomarker can be detected by forming a complex between the biomarker and a labeled probe or primer.
  • the biomarker is RNA or cDNA
  • the RNA or cDNA detected by forming a complex between the RNA or cDNA and a labeled nucleic acid probe or primer.
  • the complex between the RNA or cDNA and the labeled nucleic acid probe or primer can be a hybridization complex.
  • the protein can be detected by forming a complex between the protein and a labeled antibody.
  • the label can be any label, for example a fluorescent label, chemiluminescence label, radioactive label, etc.
  • the protein level can be measured by methods including, but not limited to, immunoprecipitation, ELISA, Western blot analysis, or immunohistochemistry using an agent, e.g., an antibody, that specifically detects the protein encoded by the gene.
  • the methods are performed by contacting the test sample with one of the provided agents, more typically with a plurality of the provided agents, for example, a set of polynucleotides that specifically bind to the at least 29 biomarkers.
  • the set of polynucleotides includes DNA, RNA, cDNA, PNA, genomic DNA, or synthetic oligonucleotides.
  • the methods include the step of isolating RNA from the test sample prior to detection, such as by RT-PCR, e.g., QPCR.
  • detection of the melanoma biomarkers, such as expression levels thereof includes detecting the presence, absence, or amount of RNA.
  • the RNA is detected by PCR or by hybridization.
  • the polynucleotides include sense and antisense primers, such as a pair of primers that is specific to each of the at least 29 biomarkers.
  • the detection of the at least 29 biomarkers is carried out by PCR, typically quantitative or real-time PCR.
  • detection is carried out by producing cDNA from the test sample by reverse transcription; then amplifying the cDNA using the pairs of sense and antisense primers that specifically hybridize to the panel of at least 28 biomarkers, and detecting products of the amplification.
  • test sample can be any biological fluid obtained from the subject.
  • test sample is blood, serum, plasma or neoplastic tissue.
  • the first predetermined cutoff value can be derived from a plurality of reference samples obtained from subjects free of a neoplastic disease.
  • Each reference sample can be any biological fluid obtained from a subject not having, showing symptoms of or diagnosed with a neoplastic disease.
  • the reference sample is blood, serum, plasma, or non-neoplastic tissue.
  • the subject in need thereof can be a subject diagnosed with a melanoma, a subject having at least one melanoma symptom or a subject having a predisposition or familial history for developing a melanoma.
  • the subject can be any mammal.
  • the subject is human.
  • the terms “subject” and “patient” are used interchangeably herein.
  • the score is the Melanomx score, which has a scale of 0 to 100.
  • the Melanomx score is the product of a classifier built from predictive classification algorithms, e.g., XGB, RF, glmnet, cforest, CART, treebag, knn, nnet, SVM-radial, SVM-linear, NB, NNET, or mlp.
  • the algorithm analyzes the data (i.e., expression levels) and then assigns a score.
  • the method can further include treating the subject identified as having a melanoma with surgery, drug therapy, radiation therapy, or a combination thereof.
  • the drug therapy can be an immunotherapy, a targeted therapy, a chemotherapy, or a combination thereof.
  • the drug therapy includes an immunotherapy.
  • immunotherapies for treating a melanoma include, but are not limited to, Imlygic (T-VEC), Yervoy in combination with Opdivo, Opdivo (nivolumab), Keytruda (pembrolizumab), Yervoy (ipilimumab), Interleukin-2 (IL-2), and Interferon alpha 2-b.
  • the drug therapy includes a targeted therapy such as a BRAF inhibitor.
  • Examples of targeted therapies for treating a melanoma include, but are not limited to, Zelboraf in combination with Cotellic (cobimetinib), Tafinlar in combination with Mekinist, Tafinlar (dabrafenib), Mekinist (trametinib), and Zelboraf (vemurafenib).
  • the drug therapy includes a chemotherapy.
  • the chemotherapy includes dacarbazine.
  • the present disclosure also provides a method for determining whether a melanoma in a subject is stable or progressive, including: (1) determining the expression level of at least 29 biomarkers from a test sample from the subject by contacting the test sample with a plurality of agents specific to detect the expression of the at least 29 biomarkers, wherein the at least 29 biomarkers comprise ATL1, ATP6V0D, C1ORF21, CFLAR, CFLAR-AS1, CHP1, DDX55, DMD, DNAJC9, ENOSF1, FANCL, HJURP, HLA-DOA, HLA-DRA, HNRNPA3P1, IL23A, IQGAP1, LOC494127, LOC646471, LOH12CR, PBXIP1, RNF5, SERTAD2, SLC35G5, SPATS2L, TDRD7, TXK, YY2, and at least one housekeeping gene; (2) normalizing the expression level of each of ATL1, ATP6V0D, C1ORF
  • the second predetermined cutoff value can be derived from a plurality of reference samples obtained from subjects whose melanomas are being adequately controlled by therapies like immune therapy.
  • Surgical resection is a procedure that removes melanoma tissues from the subject in need thereof.
  • the present disclosure also provides a method for evaluating the extent of surgical resection in a subject having a melanoma, including: (1) determining the expression level of at least 29 biomarkers from a test sample from the subject after the surgical resection by contacting the test sample with a plurality of agents specific to detect the expression of the at least 29 biomarkers, wherein the at least 29 biomarkers comprise ATL1, ATP6V0D, C1ORF21, CFLAR, CFLAR-AS1, CHP1, DDX55, DMD, DNAJC9, ENOSF1, FANCL, HJURP, HLA-DOA, HLA-DRA, HNRNPA3P1, IL23A, IQGAP1, LOC494127, LOC646471, LOH12CR, PBXIP1, RNF5, SERTAD2, SLC35G5, SPATS2L, TDRD7, TXK
  • the third predetermined cutoff value can be derived from a plurality of reference samples obtained from subjects whose melanoma disease has been completely removed by surgery and they are considered “disease free.”
  • the report further identifies that the risk of melanoma recurrence is high when the normalized expression level is equal to or greater than the third predetermined cutoff value or identifies that the risk of melanoma recurrence is low when the normalized expression level is below the third predetermined cutoff value.
  • the present disclosure also provides a method for determining a response by a subject having a melanoma to a therapy, comprising: (1) determining a first expression level of at least 28 biomarkers from a first test sample from the subject at a first time point by contacting the first test sample with a plurality of agents specific to detect the expression of the at least 28 biomarkers, wherein the 28 biomarkers comprise ATL1, ATP6V0D, C1ORF21, CFLAR, CFLAR-AS1, CHP1, DDX55, DMD, DNAJC9, ENOSF1, FANCL, HJURP, HLA-DOA, HLA-DRA, HNRNPA3P1, IL23A, IQGAP1, LOC494127, LOC646471, LOH12CR, PBXIP1, RNF5, SERTAD2, SLC35G5, SPATS2L, TDRD7, TXK, and YY2; (2) determining a second expression level of the at least 28 biomarkers from
  • the methods can predict treatment responsiveness to, or determine whether a patient has become clinically stable following, or is responsive or non-responsive to, a melanoma treatment, such as a surgical intervention or drug therapy (for example, an immunotherapy or targeted therapy).
  • a melanoma treatment such as a surgical intervention or drug therapy (for example, an immunotherapy or targeted therapy).
  • the methods can do so with a specificity, sensitivity, and/or accuracy of at least 75%, 80%, 85%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, or 99%.
  • it can differentiate between treated and untreated melanoma with a specificity, sensitivity, and/or accuracy of at least 75%, 80%, 85%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, or 99%.
  • the first and second test samples can be of the same type. In some embodiments, the first and second test samples can be of different types.
  • the therapy can be a drug therapy.
  • the drug therapy can be an immunotherapy, a targeted therapy, a chemotherapy, or a combination thereof.
  • the therapy can be a radiation therapy.
  • the first time point is prior to the administration of the therapy to the subject. In some embodiments, the first time point is after the administration of the therapy to the subject.
  • the second time point can be a few days, a few weeks, or a few months after the first time point. For example, the second time point can be at least 1 day, at least 7 days, at least 14 days, at least 30 days, at least 60 days, or at least 90 days after the first time point.
  • the second expression level is significantly decreased as compared to the first expression level when the second expression level is at least 10% less than the first expression level. In some embodiments, the second expression level is significantly decreased as compared to the first expression level when the second expression level is at least 20% less than the first expression level. In some embodiments, the second expression level is significantly decreased as compared to the first expression level when the second expression level is at least 30% less than the first expression level. In some embodiments, the second expression level is significantly decreased as compared to the first expression level when the second expression level is at least 40% less than the first expression level. In some embodiments, the second expression level is significantly decreased as compared to the first expression level when the second expression level is at least 50% less than the first expression level.
  • the second expression level is significantly decreased as compared to the first expression level when the second expression level is at least 60% less than the first expression level. In some embodiments, the second expression level is significantly decreased as compared to the first expression level when the second expression level is at least 70% less than the first expression level. In some embodiments, the second expression level is significantly decreased as compared to the first expression level when the second expression level is at least 80% less than the first expression level. In some embodiments, the second expression level is significantly decreased as compared to the first expression level when the second expression level is at least 90% less than the first expression level.
  • the method further comprises determining a third expression level of the at least 28 biomarkers from a third test sample from the subject at a third time point by contacting the third test sample with a plurality of agents specific to detect the expression of the at least 28 biomarkers, wherein the third time point is after the second time point.
  • the method can further comprise creating a plot showing the trend of the expression level change.
  • the present disclosure also provides an assay comprising: (1) determining the expression level of biomarkers consisting essentially of the following 30 biomarkers from a test sample from a patient diagnosed of a melanoma or a subject suspected of having a melanoma: ATL1, ATP6V0D, C1ORF21, CFLAR, CFLAR-AS1, CHP1, DDX55, DMD, DNAJC9, ENOSF1, FANCL, HJURP, HLA-DOA, HLA-DRA, HNRNPA3P1, IL23A, IQGAP1, LOC494127, LOC646471, LOH12CR, PBXIP1, RNF5, SERTAD2, SLC35G5, SPATS2L, TDRD7, TXK, YY2, TOX4, and TPT1, wherein the expression level is measured by contacting the test sample with a plurality of agents specific to detect the expression of the 30 biomarkers; (2) normalizing the expression level of each of ATL1, ATP6
  • the present disclosure also provides an assay comprising: (1) determining the expression level of biomarkers consisting of the following 30 biomarkers from a test sample from a patient diagnosed of a melanoma or a subject suspected of having a melanoma: ATL1, ATP6V0D, C1ORF21, CFLAR, CFLAR-AS1, CHP1, DDX55, DMD, DNAJC9, ENOSF1, FANCL, HJURP, HLA-DOA, HLA-DRA, HNRNPA3P1, IL23A, IQGAP1, LOC494127, LOC646471, LOH12CR, PBXIP1, RNF5, SERTAD2, SLC35G5, SPATS2L, TDRD7, TXK, YY2, TOX4, and TPT1, wherein the expression level is measured by contacting the test sample with a plurality of agents specific to detect the expression of the 30 biomarkers; (2) normalizing the expression level of each of ATL1, ATP6V0
  • an element means one element or more than one element.
  • nucleic acid molecule As used herein, the terms “polynucleotide” and “nucleic acid molecule” are used interchangeably to mean a polymeric form of nucleotides of at least 10 bases or base pairs in length, either ribonucleotides or deoxynucleotides or a modified form of either type of nucleotide, and is meant to include single and double stranded forms of DNA.
  • a nucleic acid molecule or nucleic acid sequence that serves as a probe in a microarray analysis preferably comprises a chain of nucleotides, more preferably DNA and/or RNA.
  • a nucleic acid molecule or nucleic acid sequence comprises other kinds of nucleic acid structures such a for instance a DNA/RNA helix, peptide nucleic acid (PNA), locked nucleic acid (LNA) and/or a ribozyme.
  • PNA peptide nucleic acid
  • LNA locked nucleic acid
  • nucleic acid molecule also encompasses a chain comprising non-natural nucleotides, modified nucleotides and/or non-nucleotide building blocks which exhibit the same function as natural nucleotides.
  • hybridize As used herein, the terms “hybridize,” “hybridizing”, “hybridizes,” and the like, used in the context of polynucleotides, are meant to refer to conventional hybridization conditions, such as hybridization in 50% formamide/6 ⁇ SSC/0.1% SDS/100 ⁇ g/ml ssDNA, in which temperatures for hybridization are above 37 degrees and temperatures for washing in 0.1 ⁇ SSC/0.1% SDS are above 55 degrees C., and preferably to stringent hybridization conditions.
  • normalization refers to the expression of a differential value in terms of a standard value to adjust for effects which arise from technical variation due to sample handling, sample preparation, and measurement methods rather than biological variation of biomarker concentration in a sample.
  • the absolute value for the expression of the protein can be expressed in terms of an absolute value for the expression of a standard protein that is substantially constant in expression.
  • diagnosis also encompass the terms “prognosis” and “prognostics”, respectively, as well as the applications of such procedures over two or more time points to monitor the diagnosis and/or prognosis over time, and statistical modeling based thereupon.
  • diagnosis includes: a. prediction (determining if a patient will likely develop aggressive disease (hyperproliferative/invasive)), b. prognosis (predicting whether a patient will likely have a better or worse outcome at a pre-selected time in the future), c. therapy selection, d. therapeutic drug monitoring, and e. relapse monitoring.
  • providing refers to directly or indirectly obtaining the biological sample from a subject.
  • “providing” may refer to the act of directly obtaining the biological sample from a subject (e.g., by a blood draw, tissue biopsy, lavage and the like).
  • “providing” may refer to the act of indirectly obtaining the biological sample.
  • providing may refer to the act of a laboratory receiving the sample from the party that directly obtained the sample, or to the act of obtaining the sample from an archive.
  • “Accuracy” refers to the degree of conformity of a measured or calculated quantity (a test reported value) to its actual (or true) value. Clinical accuracy relates to the proportion of true outcomes (true positives (TP) or true negatives (TN) versus misclassified outcomes (false positives (FP) or false negatives (FN)), and may be stated as a sensitivity, specificity, positive predictive values (PPV) or negative predictive values (NPV), or as a likelihood, odds ratio, among other measures.
  • biological sample refers to any sample of biological origin potentially containing one or more biomarkers.
  • biological samples include tissue, organs, or bodily fluids such as whole blood, plasma, serum, tissue, lavage or any other specimen used for detection of disease.
  • subject refers to a mammal, preferably a human.
  • Treating” or “treatment” as used herein with regard to a condition may refer to preventing the condition, slowing the onset or rate of development of the condition, reducing the risk of developing the condition, preventing or delaying the development of symptoms associated with the condition, reducing or ending symptoms associated with the condition, generating a complete or partial regression of the condition, or some combination thereof.
  • Biomarker levels may change due to treatment of the disease.
  • the changes in biomarker levels may be measured by the present disclosure. Changes in biomarker levels may be used to monitor the progression of disease or therapy.
  • “Altered”, “changed” or “significantly different” refer to a detectable change or difference from a reasonably comparable state, profile, measurement, or the like. Such changes may be all or none. They may be incremental and need not be linear. They may be by orders of magnitude. A change may be an increase or decrease by 1%, 5%, 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, 90%, 95%, 99%, 100%, or more, or any value in between 0% and 100%. Alternatively, the change may be 1-fold, 1.5-fold, 2-fold, 3-fold, 4-fold, 5-fold or more, or any values in between 1-fold and five-fold. The change may be statistically significant with a p value of 0.1, 0.05, 0.001, or 0.0001.
  • stable disease refers to a diagnosis for the presence of a melanoma, however the melanoma has been treated and remains in a stable condition, i.e. one that that is not progressive, as determined by imaging data and/or best clinical judgment.
  • progressive disease refers to a diagnosis for the presence of a highly active state of a melanoma, i.e. one has not been treated and is not stable or has been treated and has not responded to therapy, or has been treated and active disease remains, as determined by imaging data and/or best clinical judgment.
  • a total of 28 transcripts were identified in an unbiased manner as potential markers of melanoma behavior (Table 2).
  • the data for the utility of the test to differentiate melanoma from controls are included in Table 3.
  • the metrics are included in FIG. 2 . These are: sensitivity >90%, specificity 100%, PPV 100%, NPV 87%. The overall accuracy is 94%. The tool can therefore differentiate between controls and aggressive and stable melanoma disease.
  • test set 2 The test was evaluated in a second test set (test set 2) that included 74 controls and 92 melanoma patients.
  • the mean Melanomx score in the melanoma group was 73 ⁇ 31 versus 10 ⁇ 8 in the control group ( FIG. 3A ).
  • the receiver operator curve analysis demonstrated the score exhibited an area under the curve (AUC) of 0.96 ( FIG. 3B ) and the metrics were 88-100% ( FIG. 3C ).
  • melanoma was the source for the blood-based gene expression assay by evaluating expression in different melanoma cell lines, in tumor tissue and by comparing expression in blood with tumor tissue collected at the same time-point during surgery.

Abstract

The present invention is directed to methods for detecting a melanoma, methods for determining whether a melanoma is stable or progressive, methods for evaluating the extent of surgery resection in a subject having a melanoma, and methods for determining a response by a subject having a melanoma to a therapy.

Description

    CROSS-REFERENCE TO RELATED APPLICATIONS
  • This application claims the benefit of and priority to U.S. Provisional Application No. 62/511,058, filed on May 25, 2017, the contents of which are hereby incorporated by reference.
    • INCORPORATION BY REFERENCE OF SEQUENCE LISTING
  • The contents of the text file named “LBIO-001_001US_SEQ LISTING.txt”, which was created on May 12, 2018 and is 265 kB in size, are hereby incorporated by reference in their entireties.
    • FIELD OF THE INVENTION
  • The present invention relates to melanoma detection.
    • BACKGROUND OF THE INVENTION
  • Melanoma is a common (˜24-35/100,000 incidence—US), highly aggressive, skin cancer with an incidence that continues to rise. The most common, cutaneous melanomas, are associated with UV exposure and immune dysregulation. As a group, melanoma is known to carry the highest mutational burden (>10 mutations/Mb). Major mutations include BRAF (˜50%), N-Ras (˜20%) and NF-1 (˜5%), which together, comprise 75% of all mutations. Melanomas are addicted to MAPK pathway activation, regardless of whether tumors exhibit mutations in genes coding for proteins in this pathway. This provides the rationale for targeted therapy e.g., BRAF v600E agents, in this tumor. Other gain-of-function and loss-of-function mutations e.g., in RASopathy genes and amplification of cyclin D1/cdk4 and/or mutation/loss of the tumor suppressor PTEN, also characterize the tumor. This makes melanoma one of the most aggressive and therapy-resistant cancers.
  • Five-year survival rates range from 95-100% for stage I, 65-93% for stage II, to 41-71% and 9-28% for stage III and IV, respectively. Surgery, immunotherapy and targeted therapies provide the basis for management, with chemotherapy and radiation as adjuncts. Surgery, however, has a critical role in melanoma care (diagnosis, cure and palliation). Sentinel lymph node biopsy has become widespread, as it provides prognostic information. Melanoma, however, lacks a clinically useful non-invasive e.g., blood-based biomarker of disease activity to help guide patient management by providing predictive or prognostic information.
  • Blood-based factors include lactate dehydrogenase (LDH), detecting mutations in circulating tumor (ct) DNA, measurements of circulating tumor cells (CTCs) and circulating mRNA. LDH is typically used to identify aggressive tumor behavior and predict recurrence but its metrics are very low e.g., 30-50% accurate. It is also non-specific for melanoma. Mutations in target genes, like BRAF, can be detected in the blood in ctDNA but its utility as an indicator of therapeutic efficacy is limited e.g., 45-70% accurate. CTCs do not appear to be an accurate marker in melanomas and there is no consensus as to their clinical utility. Circulating microNAs (miRNA) have been detected but there is no evidence yet for clinical usefulness.
  • For melanomas, there are no multi-mRNA circulating biomarkers that function as a diagnostic or as a prognostic for disease recurrence. A biomarker that can be used to monitor the efficacy of surgery or drug therapy in melanomas is currently lacking.
    • SUMMARY OF THE INVENTION
  • Among other things, disclosed herein is a 28-gene expression tool for melanoma. It has high sensitivity and specificity (>95%) for the detection of melanoma and can differentiate aggressive untreated disease from stable, treated disease.
  • One aspect of the present disclosure relates to a method for detecting a melanoma in a subject in need thereof, comprising: (1) determining the expression level of at least 29 biomarkers from a test sample from the subject by contacting the test sample with a plurality of agents specific to detect the expression of the at least 29 biomarkers, wherein the at least 29 biomarkers comprise ATL1, ATP6V0D, C1ORF21, CFLAR, CFLAR-AS1, CHP1, DDX55, DMD, DNAJC9, ENOSF1, FANCL, HJURP, HLA-DOA, HLA-DRA, HNRNPA3P1, IL23A, IQGAP1, LOC494127, LOC646471, LOH12CR, PBXIP1, RNF5, SERTAD2, SLC35G5, SPATS2L, TDRD7, TXK, YY2, and at least one housekeeping gene; (2) normalizing the expression level of each of ATL1, ATP6V0D, C1ORF21, CFLAR, CFLAR-AS1, CHP1, DDX55, DMD, DNAJC9, ENOSF1, FANCL, HJURP, HLA-DOA, HLA-DRA, HNRNPA3P1, IL23A, IQGAP1, LOC494127, LOC646471, LOH12CR, PBXIP1, RNF5, SERTAD2, SLC35G5, SPATS2L, TDRD7, TXK, and YY2 to the expression level of the at least one housekeeping gene, thereby obtaining a normalized expression level of each of ATL1, ATP6V0D, C1ORF21, CFLAR, CFLAR-AS1, CHP1, DDX55, DMD, DNAJC9, ENOSF1, FANCL, HJURP, HLA-DOA, HLA-DRA, HNRNPA3P1, IL23A, IQGAP1, LOC494127, LOC646471, LOH12CR, PBXIP1, RNF5, SERTAD2, SLC35G5, SPATS2L, TDRD7, TXK, and YY2; (3) inputting each normalized expression level into an algorithm to generate a score; (4) comparing the score with a first predetermined cutoff value; and (5) producing a report, wherein the report identifies the presence of a melanoma in the subject when the score is equal to or greater than the first predetermined cutoff value or identifies the absence of a melanoma in the subject when the score is below the first predetermined cutoff value, wherein the first predetermined cutoff value is 20 on a scale of 0 to 100.
  • In some embodiments, the method further comprises treating the subject identified as having a melanoma with surgery or drug therapy.
  • Another aspect of the present disclosure relates to a method for determining whether a melanoma in a subject is stable or progressive, comprising: (1) determining the expression level of at least 29 biomarkers from a test sample from the subject by contacting the test sample with a plurality of agents specific to detect the expression of the at least 29 biomarkers, wherein the at least 29 biomarkers comprise ATL1, ATP6V0D, C1ORF21, CFLAR, CFLAR-AS1, CHP1, DDX55, DMD, DNAJC9, ENOSF1, FANCL, HJURP, HLA-DOA, HLA-DRA, HNRNPA3P1, IL23A, IQGAP1, LOC494127, LOC646471, LOH12CR, PBXIP1, RNF5, SERTAD2, SLC35G5, SPATS2L, TDRD7, TXK, YY2, and at least one housekeeping gene; (2) normalizing the expression level of each of ATL1, ATP6V0D, C1ORF21, CFLAR, CFLAR-AS1, CHP1, DDX55, DMD, DNAJC9, ENOSF1, FANCL, HJURP, HLA-DOA, HLA-DRA, HNRNPA3P1, IL23A, IQGAP1, LOC494127, LOC646471, LOH12CR, PBXIP1, RNF5, SERTAD2, SLC35G5, SPATS2L, TDRD7, TXK, and YY2 to the expression level of the at least one housekeeping gene, thereby obtaining a normalized expression level of each of ATL1, ATP6V0D, C1ORF21, CFLAR, CFLAR-AS1, CHP1, DDX55, DMD, DNAJC9, ENOSF1, FANCL, HJURP, HLA-DOA, HLA-DRA, HNRNPA3P1, IL23A, IQGAP1, LOC494127, LOC646471, LOH12CR, PBXIP1, RNF5, SERTAD2, SLC35G5, SPATS2L, TDRD7, TXK, and YY2; (3) inputting each normalized expression level into an algorithm to generate a score; (4) comparing the score with a second predetermined cutoff value; and (5) producing a report, wherein the report identifies that the melanoma is progressive when the normalized expression level is equal to or greater than the second predetermined cutoff value or identifies that the melanoma is stable when the normalized expression level is below the second predetermined cutoff value, wherein the second predetermined cutoff value is 50 on a scale of 0 to 100.
  • Another aspect of the present disclosure relates to a method for evaluating the extent of surgical resection in a subject having a melanoma, comprising: (1) determining the expression level of at least 29 biomarkers from a test sample from the subject after the surgical resection by contacting the test sample with a plurality of agents specific to detect the expression of the at least 29 biomarkers, wherein the at least 29 biomarkers comprise ATL1, ATP6V0D, C1ORF21, CFLAR, CFLAR-AS1, CHP1, DDX55, DMD, DNAJC9, ENOSF1, FANCL, HJURP, HLA-DOA, HLA-DRA, HNRNPA3P1, IL23A, IQGAP1, LOC494127, LOC646471, LOH12CR, PBXIP1, RNF5, SERTAD2, SLC35G5, SPATS2L, TDRD7, TXK, YY2, and at least one housekeeping gene; (2) normalizing the expression level of each of ATL1, ATP6V0D, C1ORF21, CFLAR, CFLAR-AS1, CHP1, DDX55, DMD, DNAJC9, ENOSF1, FANCL, HJURP, HLA-DOA, HLA-DRA, HNRNPA3P1, IL23A, IQGAP1, LOC494127, LOC646471, LOH12CR, PBXIP1, RNF5, SERTAD2, SLC35G5, SPATS2L, TDRD7, TXK, and YY2 to the expression level of the at least one housekeeping gene, thereby obtaining a normalized expression level of each of ATL1, ATP6V0D, C1ORF21, CFLAR, CFLAR-AS1, CHP1, DDX55, DMD, DNAJC9, ENOSF1, FANCL, HJURP, HLA-DOA, HLA-DRA, HNRNPA3P1, IL23A, IQGAP1, LOC494127, LOC646471, LOH12CR, PBXIP1, RNF5, SERTAD2, SLC35G5, SPATS2L, TDRD7, TXK, and YY2; (3) inputting each normalized expression level into an algorithm to generate a score; (4) comparing the score with a third predetermined cutoff value; and (5) producing a report, wherein the report identifies that the surgical resection does not remove the entire melanoma when the normalized expression level is equal to or greater than the third predetermined cutoff value or identifies that the surgical resection removes the entire melanoma when the normalized expression level is below the third predetermined cutoff value, wherein the third predetermined cutoff value is 20 on a scale of 0 to 100.
  • In some embodiments, the report further identifies that the risk of melanoma recurrence is high when the normalized expression level is equal to or greater than the third predetermined cutoff value or identifies that the risk of melanoma recurrence is low when the normalized expression level is below the third predetermined cutoff value.
  • Yet another aspect of the present disclosure relates to a method for determining a response by a subject having a melanoma to a therapy, comprising: (1) determining a first expression level of at least 28 biomarkers from a first test sample from the subject at a first time point by contacting the first test sample with a plurality of agents specific to detect the expression of the at least 28 biomarkers, wherein the 28 biomarkers comprise ATL1, ATP6V0D, C1ORF21, CFLAR, CFLAR-AS1, CHP1, DDX55, DMD, DNAJC9, ENOSF1, FANCL, HJURP, HLA-DOA, HLA-DRA, HNRNPA3P1, IL23A, IQGAP1, LOC494127, LOC646471, LOH12CR, PBXIP1, RNF5, SERTAD2, SLC35G5, SPATS2L, TDRD7, TXK, and YY2; (2) determining a second expression level of the at least 28 biomarkers from a second test sample from the subject at a second time point by contacting the second test sample with a plurality of agents specific to detect the expression of the at least 28 biomarkers, wherein the second time point is after the first time point and after the administration of the therapy to the subject; (3) comparing the first expression level with the second expression level; and (4) producing a report, wherein the report identifies that the subject is responsive to the therapy when the second expression level is significantly decreased as compared to the first expression level.
  • In some embodiments, the first time point is prior to the administration of the therapy to the subject. In some embodiments, the first time point is after the administration of the therapy to the subject. In some embodiments, the therapy comprises an immunotherapy or a targeted therapy (e.g., a BRAF inhibitor).
  • In some embodiments, the at least one housekeeping gene is selected from the group consisting of ALG9, SEPN, YWHAQ, VPS37A, PRRC2B, DOPEY2, NDUFB11, ND4, MRPL19, PSMC4, SF3A1, PUM1, ACTB, GAPD, GUSB, RPLPO, TFRC, MORF4L1, 18S, PPIA, PGK1, RPL13A, B2M, YWHAZ, SDHA, HPRT1, TOX4, and TPT1.
  • In some embodiments, the at least one housekeeping gene comprises TOX4 and TPT1.
  • In some embodiments, the normalized expression level is obtained by: (1) normalizing the expression level of each of ATL1, ATP6V0D, C1ORF21, CFLAR, CFLAR-AS1, CHP1, DDX55, DMD, DNAJC9, ENOSF1, FANCL, HJURP, HLA-DOA, HLA-DRA, HNRNPA3P1, IL23A, IQGAP1, LOC494127, LOC646471, LOH12CR, PBXIP1, RNF5, SERTAD2, SLC35G5, SPATS2L, TDRD7, TXK, and YY2 to the expression level of TOX4, thereby obtaining a first normalized expression level of each of ATL1, ATP6V0D, C1ORF21, CFLAR, CFLAR-AS1, CHP1, DDX55, DMD, DNAJC9, ENOSF1, FANCL, HJURP, HLA-DOA, HLA-DRA, HNRNPA3P1, IL23A, IQGAP1, LOC494127, LOC646471, LOH12CR, PBXIP1, RNF5, SERTAD2, SLC35G5, SPATS2L, TDRD7, TXK, and YY2; (2) normalizing the expression level of each of ATL1, ATP6V0D, C1ORF21, CFLAR, CFLAR-AS1, CHP1, DDX55, DMD, DNAJC9, ENOSF1, FANCL, HJURP, HLA-DOA, HLA-DRA, HNRNPA3P1, IL23A, IQGAP1, LOC494127, LOC646471, LOH12CR, PBXIP1, RNF5, SERTAD2, SLC35G5, SPATS2L, TDRD7, TXK, and YY2 to the expression level of TPT1, thereby obtaining a second normalized expression level of each of ATL1, ATP6V0D, C1ORF21, CFLAR, CFLAR-AS1, CHP1, DDX55, DMD, DNAJC9, ENOSF1, FANCL, HJURP, HLA-DOA, HLA-DRA, HNRNPA3P1, IL23A, IQGAP1, LOC494127, LOC646471, LOH12CR, PBXIP1, RNF5, SERTAD2, SLC35G5, SPATS2L, TDRD7, TXK, and YY2; and (3) averaging the first normalized expression level and the second normalized expression level to obtain the normalized expression level.
  • In some embodiments, the method can have a specificity, sensitivity, and/or accuracy of at least 75%, 80%, 85%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, or 99%. In some embodiments, the method has a sensitivity of greater than 90%. In some embodiments, the method has a specificity of greater than 90%.
  • In some embodiments, the biomarker is RNA, cDNA, or protein. When the biomarker is RNA, the RNA can be reverse transcribed to produce cDNA, and the produced cDNA expression level is detected. In some embodiments, the expression level of the biomarker is detected by forming a complex between the biomarker and a labeled probe or primer. When the biomarker is RNA or cDNA, the RNA or cDNA can be detected by forming a complex between the RNA or cDNA and a labeled nucleic acid probe or primer. When the biomarker is protein, the protein can be detected by forming a complex between the protein and a labeled antibody. In some embodiments, the label is a fluorescent label.
  • In some embodiments, the test sample is blood, serum, plasma, or neoplastic tissue.
  • In some embodiments, the first predetermined cutoff value can be derived from a plurality of reference samples obtained from subjects free of a neoplastic disease. The second predetermined cutoff value can be derived from a plurality of reference samples obtained from subjects whose melanomas are being adequately controlled by therapies like immune therapy. The third predetermined cutoff value can be derived from a plurality of reference samples obtained from subjects whose melanomas have been completely removed by surgery and they are considered “disease free.” In some embodiments, each reference sample can be blood, serum, plasma, or non-neoplastic tissue.
  • In some embodiments, the subject in need thereof is a subject diagnosed with a melanoma, a subject having at least one melanoma symptom, or a subject having a predisposition or familial history for developing a melanoma. In some embodiments, the subject is a human.
  • In some embodiments, the algorithm is XGB, RF, glmnet, cforest, CART, treebag, knn, nnet, SVM-radial, SVM-linear, NB, NNET, or mlp.
    • BRIEF DESCRIPTION OF THE DRAWINGS
  • FIG. 1 is a graph showing visualization of the melanoma score as a system of three contributors to the clinical picture—Control, Response, and Progression. Samples towards each of the corner represent pure representations of each clinical group. Samples in the middle are in the area of both algorithmic and clinical uncertainty.
  • FIG. 2 is a graph showing the metrics for the test in the test set ranged from 87-100%.
  • FIGS. 3A-3C are a set of graphs showing the evaluation of the circulating melanoma gene test (Melanomx) in test set 2. Values were significantly higher in melanoma samples than in controls (FIG. 3A). Patients who were responding to therapy had values similar to controls. Receiver operator curve analysis of test set 2 identifying the AUC for differentiating melanoma from controls was >0.95 (FIG. 3B). The metrics for the test ranged from 78-92% (FIG. 3C).
  • FIGS. 4A-4B are a set of graphs showing the effect of surgery on the Melanomx. Levels were significantly decreased by surgery (p<0.0001) (FIG. 4A). Values in the NED (no evidence of disease after surgery) group were significantly lower than in those with residual disease after surgery (p=0.0007) (FIG. 4B).
  • FIG. 5 is a graph showing the effect of therapy on the Melanomx score. Levels were significantly decreased by immunotherapy (ipilimumab) or a BRAF inhibitor (Vemurafenib).
  • FIGS. 6A-6B are a set of graphs showing Melanomx score in 3 different melanoma cell lines. FIG. 6A identifies the cell lines demonstrate elevated expression—Melanomx score ranging from 40 (A375) to 95 (Hs294). FIG. 6B identifies that spiking these cells into blood from a subject that does not have a melanoma, resulted in detectable gene expression and scores. A minimum of 1 cell/ml of blood could be consistently identified.
  • FIGS. 7A-7B are a set of graphs showing expression in tumor tissue and its correlation with blood samples collected at the same time. In FIG. 7A, the Melanomx score ranged 40-97 in melanoma tumor tissue. In contrast, normal epithelium exhibited values <20. In FIG. 7B, gene expression in tumor tissue is compared to matched blood samples. This is highly concordant (correlation ˜0.80).
    •  DETAILED DESCRIPTION OF THE INVENTION
  • The details of the invention are set forth in the accompanying description below. Although methods and materials similar or equivalent to those described herein can be used in the practice or testing of the present invention, illustrative methods and materials are now described. Other features, objects, and advantages of the invention will be apparent from the description and from the claims. In the specification and the appended claims, the singular forms also include the plural unless the context clearly dictates otherwise. Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. All patents and publications cited in this specification are incorporated herein by reference in their entireties.
  • Early signs of melanoma include changes to the shape or color of existing moles or, in the case of nodular melanoma, the appearance of a new lump anywhere on the skin. At later stages, the mole may itch, ulcerate or bleed. Visual inspection is the most common diagnostic technique. Melanoma can be divided into the following types: lentigo maligna, lentigo maligna melanoma, superficial spreading melanoma, acral lentiginous melanoma, mucosal melanoma, nodular melanoma, polypoid melanoma, and desmoplastic melanoma.
  • Measurements of circulating melanoma transcripts—the Melanomx—identify melanomas and decreases in the Melanomx score correlate with the efficacy of therapeutic interventions such as immunotherapy and targeted therapy. Targeted gene expression profile of RNA can be isolated from the peripheral blood of patients with melanoma. This expression profile is evaluated in an algorithm and converted to an output (prediction). It can identify active disease, provide an assessment of treatment responses, or predict risk of relapse, in conjunction with standard clinical assessment and imaging.
  • In one aspect, the present disclosure provides a method for detecting a melanoma in a subject in need thereof, including: (1) determining the expression level of at least 29 biomarkers from a test sample from the subject by contacting the test sample with a plurality of agents specific to detect the expression of the at least 29 biomarkers, wherein the at least 29 biomarkers comprise ATL1, ATP6V0D, C1ORF21, CFLAR, CFLAR-AS1, CHP1, DDX55, DMD, DNAJC9, ENOSF1, FANCL, HJURP, HLA-DOA, HLA-DRA, HNRNPA3P1, IL23A, IQGAP1, LOC494127, LOC646471, LOH12CR, PBXIP1, RNF5, SERTAD2, SLC35G5, SPATS2L, TDRD7, TXK, YY2, and at least one housekeeping gene; (2) normalizing the expression level of each of ATL1, ATP6V0D, C1ORF21, CFLAR, CFLAR-AS1, CHP1, DDX55, DMD, DNAJC9, ENOSF1, FANCL, HJURP, HLA-DOA, HLA-DRA, HNRNPA3P1, IL23A, IQGAP1, LOC494127, LOC646471, LOH12CR, PBXIP1, RNF5, SERTAD2, SLC35G5, SPATS2L, TDRD7, TXK, and YY2 to the expression level of the at least one housekeeping gene, thereby obtaining a normalized expression level of each of ATL1, ATP6V0D, C1ORF21, CFLAR, CFLAR-AS1, CHP1, DDX55, DMD, DNAJC9, ENOSF1, FANCL, HJURP, HLA-DOA, HLA-DRA, HNRNPA3P1, IL23A, IQGAP1, LOC494127, LOC646471, LOH12CR, PBXIP1, RNF5, SERTAD2, SLC35G5, SPATS2L, TDRD7, TXK, and YY2; (3) inputting each normalized expression level into an algorithm to generate a score; (4) comparing the score with a first predetermined cutoff value; and (5) producing a report, wherein the report identifies the presence of a melanoma in the subject when the score is equal to or greater than the first predetermined cutoff value or identifies the absence of a melanoma in the subject when the score is below the first predetermined cutoff value, wherein the first predetermined cutoff value is 20 on a scale of 0 to 100.
  • In some embodiments, the at least one housekeeping gene is selected from the group consisting of ALG9, SEPN, YWHAQ, VPS37A, PRRC2B, DOPEY2, NDUFB11, ND4, MRPL19, PSMC4, SF3A1, PUM1, ACTB, GAPD, GUSB, RPLPO, TFRC, MORF4L1, 18S, PPIA, PGK1, RPL13A, B2M, YWHAZ, SDHA, HPRT1, TOX4, and TPT1.
  • In some embodiments, the at least one housekeeping gene comprises TOX4 and TPT1. In some embodiments, the normalized expression level is obtained by: (1) normalizing the expression level of each of ATL1, ATP6V0D, C1ORF21, CFLAR, CFLAR-AS1, CHP1, DDX55, DMD, DNAJC9, ENOSF1, FANCL, HJURP, HLA-DOA, HLA-DRA, HNRNPA3P1, IL23A, IQGAP1, LOC494127, LOC646471, LOH12CR, PBXIP1, RNF5, SERTAD2, SLC35G5, SPATS2L, TDRD7, TXK, and YY2 to the expression level of TOX4, thereby obtaining a first normalized expression level of each of ATL1, ATP6V0D, C1ORF21, CFLAR, CFLAR-AS1, CHP1, DDX55, DMD, DNAJC9, ENOSF1, FANCL, HJURP, HLA-DOA, HLA-DRA, HNRNPA3P1, IL23A, IQGAP1, LOC494127, LOC646471, LOH12CR, PBXIP1, RNF5, SERTAD2, SLC35G5, SPATS2L, TDRD7, TXK, and YY2; (2) normalizing the expression level of each of ATL1, ATP6V0D, C1ORF21, CFLAR, CFLAR-AS1, CHP1, DDX55, DMD, DNAJC9, ENOSF1, FANCL, HJURP, HLA-DOA, HLA-DRA, HNRNPA3P1, IL23A, IQGAP1, LOC494127, LOC646471, LOH12CR, PBXIP1, RNF5, SERTAD2, SLC35G5, SPATS2L, TDRD7, TXK, and YY2 to the expression level of TPT1, thereby obtaining a second normalized expression level of each of ATL1, ATP6V0D, C1ORF21, CFLAR, CFLAR-AS1, CHP1, DDX55, DMD, DNAJC9, ENOSF1, FANCL, HJURP, HLA-DOA, HLA-DRA, HNRNPA3P1, IL23A, IQGAP1, LOC494127, LOC646471, LOH12CR, PBXIP1, RNF5, SERTAD2, SLC35G5, SPATS2L, TDRD7, TXK, and YY2; and (3) averaging the first normalized expression level and the second normalized expression level to obtain the normalized expression level.
  • Among the provided methods are those that are able to classify or detect a melanoma. In some embodiments, the provided methods can identify or classify a melanoma in a human blood sample. In some examples, the methods can provide such information with a specificity, sensitivity, and/or accuracy of at least 75%, 80%, 85%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, or 99%.
  • The agents can be any agents for detection of the biomarkers, and typically are isolated polynucleotides or isolated polypeptides or proteins, such as antibodies, for example, those that specifically hybridize to or bind to the at least 29 biomarkers.
  • The biomarker can be RNA, cDNA, or protein. When the biomarker is RNA, the RNA can be reverse transcribed to produce cDNA (such as by RT-PCR), and the produced cDNA expression level is detected. The expression level of the biomarker can be detected by forming a complex between the biomarker and a labeled probe or primer. When the biomarker is RNA or cDNA, the RNA or cDNA detected by forming a complex between the RNA or cDNA and a labeled nucleic acid probe or primer. The complex between the RNA or cDNA and the labeled nucleic acid probe or primer can be a hybridization complex.
  • When the biomarker is protein, the protein can be detected by forming a complex between the protein and a labeled antibody. The label can be any label, for example a fluorescent label, chemiluminescence label, radioactive label, etc. The protein level can be measured by methods including, but not limited to, immunoprecipitation, ELISA, Western blot analysis, or immunohistochemistry using an agent, e.g., an antibody, that specifically detects the protein encoded by the gene.
  • In some embodiments, the methods are performed by contacting the test sample with one of the provided agents, more typically with a plurality of the provided agents, for example, a set of polynucleotides that specifically bind to the at least 29 biomarkers. In some embodiments, the set of polynucleotides includes DNA, RNA, cDNA, PNA, genomic DNA, or synthetic oligonucleotides. In some embodiments, the methods include the step of isolating RNA from the test sample prior to detection, such as by RT-PCR, e.g., QPCR. Thus, in some embodiments, detection of the melanoma biomarkers, such as expression levels thereof, includes detecting the presence, absence, or amount of RNA. In one example, the RNA is detected by PCR or by hybridization.
  • In some embodiments, the polynucleotides include sense and antisense primers, such as a pair of primers that is specific to each of the at least 29 biomarkers. In one aspect of this embodiment, the detection of the at least 29 biomarkers is carried out by PCR, typically quantitative or real-time PCR. For example, in one aspect, detection is carried out by producing cDNA from the test sample by reverse transcription; then amplifying the cDNA using the pairs of sense and antisense primers that specifically hybridize to the panel of at least 28 biomarkers, and detecting products of the amplification.
  • The test sample can be any biological fluid obtained from the subject. Preferably, the test sample is blood, serum, plasma or neoplastic tissue.
  • The first predetermined cutoff value can be derived from a plurality of reference samples obtained from subjects free of a neoplastic disease. Each reference sample can be any biological fluid obtained from a subject not having, showing symptoms of or diagnosed with a neoplastic disease. In some embodiments, the reference sample is blood, serum, plasma, or non-neoplastic tissue.
  • The subject in need thereof can be a subject diagnosed with a melanoma, a subject having at least one melanoma symptom or a subject having a predisposition or familial history for developing a melanoma. The subject can be any mammal. Preferably, the subject is human. The terms “subject” and “patient” are used interchangeably herein.
  • The score is the Melanomx score, which has a scale of 0 to 100. The Melanomx score is the product of a classifier built from predictive classification algorithms, e.g., XGB, RF, glmnet, cforest, CART, treebag, knn, nnet, SVM-radial, SVM-linear, NB, NNET, or mlp. The algorithm analyzes the data (i.e., expression levels) and then assigns a score.
  • The method can further include treating the subject identified as having a melanoma with surgery, drug therapy, radiation therapy, or a combination thereof. The drug therapy can be an immunotherapy, a targeted therapy, a chemotherapy, or a combination thereof. In some embodiments, the drug therapy includes an immunotherapy. Examples of immunotherapies for treating a melanoma include, but are not limited to, Imlygic (T-VEC), Yervoy in combination with Opdivo, Opdivo (nivolumab), Keytruda (pembrolizumab), Yervoy (ipilimumab), Interleukin-2 (IL-2), and Interferon alpha 2-b. In some embodiments, the drug therapy includes a targeted therapy such as a BRAF inhibitor. Examples of targeted therapies for treating a melanoma include, but are not limited to, Zelboraf in combination with Cotellic (cobimetinib), Tafinlar in combination with Mekinist, Tafinlar (dabrafenib), Mekinist (trametinib), and Zelboraf (vemurafenib). In some embodiments, the drug therapy includes a chemotherapy. In some embodiments, the chemotherapy includes dacarbazine.
  • The present disclosure also provides a method for determining whether a melanoma in a subject is stable or progressive, including: (1) determining the expression level of at least 29 biomarkers from a test sample from the subject by contacting the test sample with a plurality of agents specific to detect the expression of the at least 29 biomarkers, wherein the at least 29 biomarkers comprise ATL1, ATP6V0D, C1ORF21, CFLAR, CFLAR-AS1, CHP1, DDX55, DMD, DNAJC9, ENOSF1, FANCL, HJURP, HLA-DOA, HLA-DRA, HNRNPA3P1, IL23A, IQGAP1, LOC494127, LOC646471, LOH12CR, PBXIP1, RNF5, SERTAD2, SLC35G5, SPATS2L, TDRD7, TXK, YY2, and at least one housekeeping gene; (2) normalizing the expression level of each of ATL1, ATP6V0D, C1ORF21, CFLAR, CFLAR-AS1, CHP1, DDX55, DMD, DNAJC9, ENOSF1, FANCL, HJURP, HLA-DOA, HLA-DRA, HNRNPA3P1, IL23A, IQGAP1, LOC494127, LOC646471, LOH12CR, PBXIP1, RNF5, SERTAD2, SLC35G5, SPATS2L, TDRD7, TXK, and YY2 to the expression level of the at least one housekeeping gene, thereby obtaining a normalized expression level of each of ATL1, ATP6V0D, C1ORF21, CFLAR, CFLAR-AS1, CHP1, DDX55, DMD, DNAJC9, ENOSF1, FANCL, HJURP, HLA-DOA, HLA-DRA, HNRNPA3P1, IL23A, IQGAP1, LOC494127, LOC646471, LOH12CR, PBXIP1, RNF5, SERTAD2, SLC35G5, SPATS2L, TDRD7, TXK, and YY2; (3) inputting each normalized expression level into an algorithm to generate a score; (4) comparing the score with a second predetermined cutoff value; and (5) producing a report, wherein the report identifies that the melanoma is progressive when the normalized expression level is equal to or greater than the second predetermined cutoff value or identifies that the melanoma is stable when the normalized expression level is below the second predetermined cutoff value, wherein the second predetermined cutoff value is 50 on a scale of 0 to 100.
  • The second predetermined cutoff value can be derived from a plurality of reference samples obtained from subjects whose melanomas are being adequately controlled by therapies like immune therapy.
  • Surgical resection is a procedure that removes melanoma tissues from the subject in need thereof. The present disclosure also provides a method for evaluating the extent of surgical resection in a subject having a melanoma, including: (1) determining the expression level of at least 29 biomarkers from a test sample from the subject after the surgical resection by contacting the test sample with a plurality of agents specific to detect the expression of the at least 29 biomarkers, wherein the at least 29 biomarkers comprise ATL1, ATP6V0D, C1ORF21, CFLAR, CFLAR-AS1, CHP1, DDX55, DMD, DNAJC9, ENOSF1, FANCL, HJURP, HLA-DOA, HLA-DRA, HNRNPA3P1, IL23A, IQGAP1, LOC494127, LOC646471, LOH12CR, PBXIP1, RNF5, SERTAD2, SLC35G5, SPATS2L, TDRD7, TXK, YY2, and at least one housekeeping gene; (2) normalizing the expression level of each of ATL1, ATP6V0D, C1ORF21, CFLAR, CFLAR-AS1, CHP1, DDX55, DMD, DNAJC9, ENOSF1, FANCL, HJURP, HLA-DOA, HLA-DRA, HNRNPA3P1, IL23A, IQGAP1, LOC494127, LOC646471, LOH12CR, PBXIP1, RNF5, SERTAD2, SLC35G5, SPATS2L, TDRD7, TXK, and YY2 to the expression level of the at least one housekeeping gene, thereby obtaining a normalized expression level of each of ATL1, ATP6V0D, C1ORF21, CFLAR, CFLAR-AS1, CHP1, DDX55, DMD, DNAJC9, ENOSF1, FANCL, HJURP, HLA-DOA, HLA-DRA, HNRNPA3P1, IL23A, IQGAP1, LOC494127, LOC646471, LOH12CR, PBXIP1, RNF5, SERTAD2, SLC35G5, SPATS2L, TDRD7, TXK, and YY2; (3) inputting each normalized expression level into an algorithm to generate a score; (4) comparing the score with a third predetermined cutoff value; and (5) producing a report, wherein the report identifies that the surgical resection does not remove the entire melanoma when the normalized expression level is equal to or greater than the third predetermined cutoff value or identifies that the surgical resection removes the entire melanoma when the normalized expression level is below the third predetermined cutoff value, wherein the third predetermined cutoff value is 20 on a scale of 0 to 100.
  • The third predetermined cutoff value can be derived from a plurality of reference samples obtained from subjects whose melanoma disease has been completely removed by surgery and they are considered “disease free.”
  • When it is determined that the surgical resection does not remove the entire melanoma, the subject is at risk of melanoma recurrence. Accordingly, in some embodiments, the report further identifies that the risk of melanoma recurrence is high when the normalized expression level is equal to or greater than the third predetermined cutoff value or identifies that the risk of melanoma recurrence is low when the normalized expression level is below the third predetermined cutoff value.
  • The present disclosure also provides a method for determining a response by a subject having a melanoma to a therapy, comprising: (1) determining a first expression level of at least 28 biomarkers from a first test sample from the subject at a first time point by contacting the first test sample with a plurality of agents specific to detect the expression of the at least 28 biomarkers, wherein the 28 biomarkers comprise ATL1, ATP6V0D, C1ORF21, CFLAR, CFLAR-AS1, CHP1, DDX55, DMD, DNAJC9, ENOSF1, FANCL, HJURP, HLA-DOA, HLA-DRA, HNRNPA3P1, IL23A, IQGAP1, LOC494127, LOC646471, LOH12CR, PBXIP1, RNF5, SERTAD2, SLC35G5, SPATS2L, TDRD7, TXK, and YY2; (2) determining a second expression level of the at least 28 biomarkers from a second test sample from the subject at a second time point by contacting the second test sample with a plurality of agents specific to detect the expression of the at least 28 biomarkers, wherein the second time point is after the first time point and after the administration of the therapy to the subject; (3) comparing the first expression level with the second expression level; and (4) determining that the subject is responsive to the therapy when the second expression level is significantly decreased as compared to the first expression level.
  • In some embodiments, the methods can predict treatment responsiveness to, or determine whether a patient has become clinically stable following, or is responsive or non-responsive to, a melanoma treatment, such as a surgical intervention or drug therapy (for example, an immunotherapy or targeted therapy). In some cases, the methods can do so with a specificity, sensitivity, and/or accuracy of at least 75%, 80%, 85%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, or 99%. In some cases, it can differentiate between treated and untreated melanoma with a specificity, sensitivity, and/or accuracy of at least 75%, 80%, 85%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, or 99%.
  • In some embodiments, the first and second test samples can be of the same type. In some embodiments, the first and second test samples can be of different types.
  • In some embodiments, the therapy can be a drug therapy. The drug therapy can be an immunotherapy, a targeted therapy, a chemotherapy, or a combination thereof. In some embodiments, the therapy can be a radiation therapy.
  • In some embodiments, the first time point is prior to the administration of the therapy to the subject. In some embodiments, the first time point is after the administration of the therapy to the subject. The second time point can be a few days, a few weeks, or a few months after the first time point. For example, the second time point can be at least 1 day, at least 7 days, at least 14 days, at least 30 days, at least 60 days, or at least 90 days after the first time point.
  • In some embodiments, the second expression level is significantly decreased as compared to the first expression level when the second expression level is at least 10% less than the first expression level. In some embodiments, the second expression level is significantly decreased as compared to the first expression level when the second expression level is at least 20% less than the first expression level. In some embodiments, the second expression level is significantly decreased as compared to the first expression level when the second expression level is at least 30% less than the first expression level. In some embodiments, the second expression level is significantly decreased as compared to the first expression level when the second expression level is at least 40% less than the first expression level. In some embodiments, the second expression level is significantly decreased as compared to the first expression level when the second expression level is at least 50% less than the first expression level. In some embodiments, the second expression level is significantly decreased as compared to the first expression level when the second expression level is at least 60% less than the first expression level. In some embodiments, the second expression level is significantly decreased as compared to the first expression level when the second expression level is at least 70% less than the first expression level. In some embodiments, the second expression level is significantly decreased as compared to the first expression level when the second expression level is at least 80% less than the first expression level. In some embodiments, the second expression level is significantly decreased as compared to the first expression level when the second expression level is at least 90% less than the first expression level.
  • In some embodiments, the method further comprises determining a third expression level of the at least 28 biomarkers from a third test sample from the subject at a third time point by contacting the third test sample with a plurality of agents specific to detect the expression of the at least 28 biomarkers, wherein the third time point is after the second time point. The method can further comprise creating a plot showing the trend of the expression level change.
  • The present disclosure also provides an assay comprising: (1) determining the expression level of biomarkers consisting essentially of the following 30 biomarkers from a test sample from a patient diagnosed of a melanoma or a subject suspected of having a melanoma: ATL1, ATP6V0D, C1ORF21, CFLAR, CFLAR-AS1, CHP1, DDX55, DMD, DNAJC9, ENOSF1, FANCL, HJURP, HLA-DOA, HLA-DRA, HNRNPA3P1, IL23A, IQGAP1, LOC494127, LOC646471, LOH12CR, PBXIP1, RNF5, SERTAD2, SLC35G5, SPATS2L, TDRD7, TXK, YY2, TOX4, and TPT1, wherein the expression level is measured by contacting the test sample with a plurality of agents specific to detect the expression of the 30 biomarkers; (2) normalizing the expression level of each of ATL1, ATP6V0D, C1ORF21, CFLAR, CFLAR-AS1, CHP1, DDX55, DMD, DNAJC9, ENOSF1, FANCL, HJURP, HLA-DOA, HLA-DRA, HNRNPA3P1, IL23A, IQGAP1, LOC494127, LOC646471, LOH12CR, PBXIP1, RNF5, SERTAD2, SLC35G5, SPATS2L, TDRD7, TXK, and YY2 to the expression level of TOX4, thereby obtaining a first normalized expression level of each of ATL1, ATP6V0D, C1ORF21, CFLAR, CFLAR-AS1, CHP1, DDX55, DMD, DNAJC9, ENOSF1, FANCL, HJURP, HLA-DOA, HLA-DRA, HNRNPA3P1, IL23A, IQGAP1, LOC494127, LOC646471, LOH12CR, PBXIP1, RNF5, SERTAD2, SLC35G5, SPATS2L, TDRD7, TXK, and YY2; (3) normalizing the expression level of each of ATL1, ATP6V0D, C1ORF21, CFLAR, CFLAR-AS1, CHP1, DDX55, DMD, DNAJC9, ENOSF1, FANCL, HJURP, HLA-DOA, HLA-DRA, HNRNPA3P1, IL23A, IQGAP1, LOC494127, LOC646471, LOH12CR, PBXIP1, RNF5, SERTAD2, SLC35G5, SPATS2L, TDRD7, TXK, and YY2 to the expression level of TPT1, thereby obtaining a second normalized expression level of each of ATL1, ATP6V0D, C1ORF21, CFLAR, CFLAR-AS1, CHP1, DDX55, DMD, DNAJC9, ENOSF1, FANCL, HJURP, HLA-DOA, HLA-DRA, HNRNPA3P1, IL23A, IQGAP1, LOC494127, LOC646471, LOH12CR, PBXIP1, RNF5, SERTAD2, SLC35G5, SPATS2L, TDRD7, TXK, and YY2; (4) averaging the first normalized expression level and the second normalized expression level to obtain a normalized expression level for each biomarker; (5) inputting each normalized expression level into an algorithm to generate a score; and (6) comparing the score with a first predetermined cutoff value.
  • The present disclosure also provides an assay comprising: (1) determining the expression level of biomarkers consisting of the following 30 biomarkers from a test sample from a patient diagnosed of a melanoma or a subject suspected of having a melanoma: ATL1, ATP6V0D, C1ORF21, CFLAR, CFLAR-AS1, CHP1, DDX55, DMD, DNAJC9, ENOSF1, FANCL, HJURP, HLA-DOA, HLA-DRA, HNRNPA3P1, IL23A, IQGAP1, LOC494127, LOC646471, LOH12CR, PBXIP1, RNF5, SERTAD2, SLC35G5, SPATS2L, TDRD7, TXK, YY2, TOX4, and TPT1, wherein the expression level is measured by contacting the test sample with a plurality of agents specific to detect the expression of the 30 biomarkers; (2) normalizing the expression level of each of ATL1, ATP6V0D, C1ORF21, CFLAR, CFLAR-AS1, CHP1, DDX55, DMD, DNAJC9, ENOSF1, FANCL, HJURP, HLA-DOA, HLA-DRA, HNRNPA3P1, IL23A, IQGAP1, LOC494127, LOC646471, LOH12CR, PBXIP1, RNF5, SERTAD2, SLC35G5, SPATS2L, TDRD7, TXK, and YY2 to the expression level of TOX4, thereby obtaining a first normalized expression level of each of ATL1, ATP6V0D, C1ORF21, CFLAR, CFLAR-AS1, CHP1, DDX55, DMD, DNAJC9, ENOSF1, FANCL, HJURP, HLA-DOA, HLA-DRA, HNRNPA3P1, IL23A, IQGAP1, LOC494127, LOC646471, LOH12CR, PBXIP1, RNF5, SERTAD2, SLC35G5, SPATS2L, TDRD7, TXK, and YY2; (3) normalizing the expression level of each of ATL1, ATP6V0D, C1ORF21, CFLAR, CFLAR-AS1, CHP1, DDX55, DMD, DNAJC9, ENOSF1, FANCL, HJURP, HLA-DOA, HLA-DRA, HNRNPA3P1, IL23A, IQGAP1, LOC494127, LOC646471, LOH12CR, PBXIP1, RNF5, SERTAD2, SLC35G5, SPATS2L, TDRD7, TXK, and YY2 to the expression level of TPT1, thereby obtaining a second normalized expression level of each of ATL1, ATP6V0D, C1ORF21, CFLAR, CFLAR-AS1, CHP1, DDX55, DMD, DNAJC9, ENOSF1, FANCL, HJURP, HLA-DOA, HLA-DRA, HNRNPA3P1, IL23A, IQGAP1, LOC494127, LOC646471, LOH12CR, PBXIP1, RNF5, SERTAD2, SLC35G5, SPATS2L, TDRD7, TXK, and YY2; (4) averaging the first normalized expression level and the second normalized expression level to obtain a normalized expression level for each biomarker; (5) inputting each normalized expression level into an algorithm to generate a score; and (6) comparing the score with a first predetermined cutoff value.
  • The sequence information of the melanoma biomarkers and housekeepers is shown in Table 1.
  • TABLE 1
    Melanoma Biomarker/Housekeeper Sequence Information
    SEQ
    Gene RefSeq ID
    Name Accession Sequence NO:
    ATL1 NM_001127713.1 AGTTTGAGGC TGCACTGCAC ACCTGCACAA CCTGCCTTCT 1
    ACTTAGTTCT TCTGAGACAT TTCTGAAAGT CTGAATTCCT
    AGGACTGCTC AATGACCTTT GTCCCTGTTG GGCACACGCA
    GTGTCTCATC GCTGGTATTG CACCTTTAAT GAGACCAGGA
    GTTCCGCAAA AGTAAAACAA AGGGGTCACA GACTGGTTCT
    GGTTCTACCA CTTCCTCAGT ATGTGCTCTG GGACAAAACA
    GCATATTTGG CAACATCTCG GTGTCCTTAT CTGCAGCTTG
    AAGAGGCGCC ACAGCAACAT CCTCAGAGTC TGAGCGAACT
    GCGCCCAGCG CGGGCACGGA GCCTCCCACC GCCAGCAACC
    TGCGGCCCCG GAGAAGGCAG CGAGCGCAGT GACAGCGCCT
    CACCGCCACC AGCTCCTGGA CCACCATGGC CAAGAACCGC
    AGGGACAGAA ACAGTTGGGG TGGATTTTCG GAAAAGACAT
    ATGAATGGAG CTCAGAAGAG GAGGAGCCAG TGAAAAAGGC
    AGGACCAGTC CAAGTCCTCA TTGTCAAAGA TGACCATTCC
    TTTGAGTTAG ATGAAACTGC ATTAAATCGG ATCCTTCTCT
    CGGAGGCTGT CAGAGACAAG GAGGTTGTTG CTGTATCTGT
    TGCTGGAGCA TTTAGAAAAG GAAAATCATT CCTGATGGAC
    TTCATGTTGA GATACATGTA CAACCAGGAA TCAGTTGATT
    GGGTTGGAGA CTACAATGAA CCATTGACTG GTTTTTCATG
    GAGAGGTGGA TCTGAGCGAG AGACCACAGG AATTCAGATA
    TGGAGTGAAA TCTTCCTTAT CAATAAACCT GATGGTAAAA
    AGGTTGCAGT GTTATTGATG GATACTCAGG GAACCTTTGA
    TAGTCAGTCA ACTTTGAGAG ATTCAGCCAC AGTATTTGCC
    CTTAGCACAA TGATCAGCTC AATACAGGTA TATAACTTAT
    CCCAAAATGT CCAGGAGGAT GATCTTCAGC ACCTCCAGCT
    TTTCACTGAG TATGGCAGAC TGGCAATGGA GGAAACATTC
    CTGAAGCCAT TTCAGAGTCT GATATTTCTT GTTCGAGACT
    GGAGTTTCCC ATACGAATTT TCATATGGAG CCGATGGTGG
    TGCCAAATTC TTGGAAAAAC GCCTCAAGGT CTCAGGGAAC
    CAGCATGAAG AACTACAGAA CGTCAGAAAA CACATCCATT
    CCTGTTTCAC CAACATTTCC TGTTTTCTGC TACCTCATCC
    TGGCTTAAAA GTAGCTACCA ATCCAAACTT TGATGGAAAA
    TTGAAAGAAA TAGATGATGA ATTCATCAAA AACTTGAAAA
    TACTGATTCC TTGGCTACTT AGTCCCGAGA GCCTAGATAT
    TAAAGAGATC AATGGGAATA AAATCACCTG CCGGGGTCTG
    GTGGAGTACT TCAAGGCTTA TATAAAGATC TATCAAGGTG
    AAGAATTACC ACATCCCAAA TCCATGTTAC AGGCCACAGC
    AGAAGCTAAC AATTTAGCAG CCGTGGCAAC TGCCAAGGAC
    ACATACAACA AAAAAATGGA AGAGATTTGT GGTGGTGACA
    AACCATTTCT GGCCCCAAAT GACTTGCAGA CCAAACACCT
    GCAACTTAAG GAAGAATCTG TGAAGCTATT CCGAGGGGTG
    AAGAAGATGG GTGGGGAAGA ATTTAGCCGG CGTTACCTGC
    AGCAGTTGGA GAGTGAAATA GATGAACTTT ACATCCAATA
    TATCAAGCAC AATGATAGCA AAAATATCTT CCATGCAGCT
    CGTACCCCAG CCACACTGTT TGTAGTCATC TTTATCACAT
    ATGTGATTGC TGGTGTGACT GGATTCATTG GTTTGGACAT
    CATAGCTAGC CTATGCAATA TGATAATGGG ACTGACCCTT
    ATCACCCTGT GCACTTGGGC ATATATCCGG TACTCTGGAG
    AATACCGAGA GCTGGGAGCT GTAATAGACC AGGTGGCTGC
    AGCTCTGTGG GACCAGGCTT TGTACAAGCT TTACAGTGCA
    GCAGCAACCC ACAGACATCT GTATCATCAA GCTTTCCCTA
    CACCAAAGTC GGAATCTACT GAACAATCAG AAAAGAAAAA
    AATGTAATGC AAATTTTAAG AAATACAGGT GCATGACCAA
    TTGTCAATTA AATATTCAGT TTTATGTCTC CATGCAAACA
    TTCAAAGTGC TTCCATCAGA ACGGAGTAAA ATACTAAACA
    CCTCTGAAGA CTGCAAACTG GATTAGTTCT TTTACTTCAG
    TGTTTAATAA GCAGATGTAT GTATGCATGG TTATACTATT
    TTGTTAACAT GTACAATTTC CTGATTTTTC TTCAAAAATG
    CTGTTATAAA GTATTTGTCT ATTTATGATA ACAGTACACG
    TGTTCTGCTT GAATTTACTA AATTCTACTA CTGGGTTATA
    ATTAAATCAT GTGATATTCC ACGTTTGGAT ATGCTCATTT
    AATTTCTACA GAAAAAATTT TAAATTATTT CACATTAGCC
    ATTTGTTAAA ACACAGCATC ATAACTCAGC AGGCTGGATT
    TAATCTGTAT CATCTTATAT ATATCACAAT CTTATTTTTA
    AGCACATTTT AGAGTTCCTT AGTTGCTTTA TCAAAAACCA
    GATATTGCTT TTACATGGTT TAATAGAATA TAAACCTCTT
    GATAAAAAAT GCACAAAAAA TCACTTTGTA TATGTGAGTT
    TCACTGCATT GTATATTTTT TCATTTGGTA CACAAAGAAT
    GTATTCTTCA TAGGTTTATT CTTTTAATAT GTGAACTATT
    ATTAAAGTTT ACTCTGGTTC CTAAGATTAA AAACAAATGC
    TTACTGAATT TGAAAAAAAA A
    ATP6V0D NM_004691.4 ACTTGACAGC CCGCTGAGGA CGCAGCGTCA GCTGACCTGG 2
    GGAGTCGCGA TTCGTGCCGG CCGGTCCTGG TTCTCCGGTC
    CCGCCGCTCC CGCAGCAGCC ATGTCGTTCT TCCCGGAGCT
    TTACTTTAAC GTGGACAATG GCTACTTGGA GGGACTGGTG
    CGCGGCCTGA AGGCCGGGGT GCTCAGCCAG GCCGACTACC
    TCAACCTGGT GCAGTGCGAG ACGCTAGAGG ACTTGAAACT
    GCATCTGCAG AGCACTGATT ATGGTAACTT CCTGGCCAAC
    GAGGCATCAC CTCTGACGGT GTCAGTCATC GATGACCGGC
    TCAAGGAGAA GATGGTGGTG GAGTTCCGCC ACATGAGGAA
    CCATGCCTAT GAGCCACTCG CCAGCTTCCT AGACTTCATT
    ACTTACAGTT ACATGATCGA CAACGTGATC CTGCTCATCA
    CAGGCACGCT GCACCAGCGC TCCATCGCTG AGCTCGTGCC
    CAAGTGCCAC CCACTAGGCA GCTTCGAGCA GATGGAGGCC
    GTGAACATTG CTCAGACACC TGCTGAGCTC TACAATGCCA
    TTCTGGTGGA CACGCCTCTT GCGGCTTTTT TCCAGGACTG
    CATTTCAGAG CAGGACCTTG ACGAGATGAA CATCGAGATC
    ATCCGCAACA CCCTCTACAA GGCCTACCTG GAGTCCTTCT
    ACAAGTTCTG CACCCTACTG GGCGGGACTA CGGCTGATGC
    CATGTGCCCC ATCCTGGAGT TTGAAGCAGA CCGCCGCGCC
    TTCATCATCA CCATCAATTC TTTCGGCACA GAGCTGTCCA
    AAGAGGACCG TGCCAAGCTC TTTCCACACT GTGGGCGGCT
    CTACCCTGAG GGCCTGGCGC AGCTGGCTCG GGCTGACGAC
    TATGAACAGG TCAAGAACGT GGCCGATTAC TACCCGGAGT
    ACAAGCTGCT CTTCGAGGGT GCAGGTAGCA ACCCTGGAGA
    CAAGACGCTG GAGGACCGAT TCTTTGAGCA CGAGGTAAAG
    CTGAACAAGT TGGCCTTCCT GAACCAGTTC CACTTTGGTG
    TCTTCTATGC CTTCGTGAAG CTCAAGGAGC AGGAGTGTCG
    CAACATCGTG TGGATCGCTG AATGTATCGC CCAGCGCCAC
    CGCGCCAAAA TCGACAACTA CATCCCTATC TTCTAGCGTC
    CTGGCCCAAG GCTCTCAATT GCACTCTTTG TGTGTGTGTG
    TGTGTGTGTG CGCGTGTGTG TGCGTGTGTG TGTATGTGGT
    CTGTGACAAG CCTGTGGCTC ACCTGCCTGT CCGGGGTGTA
    GTACGCTGTC CTAGCGGCTG CCCAGTTCTC CTGACCCTCT
    TAGAGACTGT TCTTAGGCCT GAAAAGGGGC TGGGCACCCC
    CCCCCACCAA GGATGGACGA AGACCCCCTC CAGAGCAAGG
    AGGCCCCCTC AGCCCTGTGG TTACAGCCGC TGATGTATCT
    AAGAAGCATG TCACTTTCAT GTTCCTCCCT AACTCCCTGA
    CCTGAGAACC CTGGGGCCTG GGGGCAGTTT GAGCCTCCTC
    TCCCTTCTGT GGGTCGCTCC CAGAGCCATG GCCCATGGGA
    AGGACAGAGT GTGTGTGTCC TTGGGGCCTG GGGGGATGTT
    GCTCCTCAGC TCCCTCCCTC AGCCCTGCCC CTCTGAGACA
    ATAAAACTGC CCTCTCTAAG GCCAACTGTC AAAAAAAAAA
    AAAAAAAA
    C1ORF21 NM_030806.3 CCCTCCCTCG CTCGCTCCTC GCAAGCTCCC GCTCGCTCCC 3
    TGCCCACTCC CGGGGGGACG TTCCGTGCCG CGGCCGCCGC
    GGCCGCTGCT TCTTTCACAC TTTAGTTGGG AGCTGCGCGC
    CGCGCTCAGT TACTGGAGAG CTGGCCGCGC GCCGCCGCCT
    CCCGCACGCT TGCACGCGGG CCCGGCTTCG GGGTTTTGGG
    TTCTTACTCC AAGCGGCGGG GAGGAGGGGG AGCCCCGGAC
    ACACTGTGGG GAGGAGGAGG AAGAAGAGGA GGAGGGAGGA
    AGAAAAAAGA CGAGGAGGAC AGGGGCGGGG GGCGGGAGGC
    TTGCCACCTT CAGCCCCCCC GCGAACGCCC AAGGTGCACA
    CATCTTGACC AACTCAGCAG CAAGGTGGAT TTTCTTTGTG
    TTTAAAGAAA AAAAATGTCC CTGTGTCTGT AGAGATGATT
    TGCAGTTCAG CCCGGCTGAA GCTGACCGAA TGAGACTATG
    GGCTGTGCCT CCGCCAAGCA TGTTGCCACT GTTCAAAATG
    AAGAGGAAGC CCAGAAAGGG AAAAACTACC AGAACGGAGA
    TGTGTTTGGC GATGAGTATA GGATCAAACC AGTGGAAGAG
    GTCAAATACA TGAAAAATGG GGCAGAAGAA GAGCAGAAAA
    TAGCAGCCAG GAACCAAGAA AACTTGGAAA AAAGTGCCAG
    CTCAAATGTA AGACTTAAAA CTAATAAAGA GGTTCCGGGA
    TTAGTTCATC AACCCAGAGC AAACATGCAC ATCTCTGAAA
    GCCAACAAGA ATTCTTCAGA ATGCTGGATG AAAAAATTGA
    AAAGGGTCGG GATTACTGTT CGGAAGAAGA GGATATCACA
    TAGCACCAAT TTTACCACTC AAACCAGGAG CTACTACTGT
    GTAAATAGGT TACACCCCAG TTGAAATCTT TGCAAAGGTC
    GGTTCTATTC AGCGAACAGC ACTATAGCAA AAGAAGATCG
    TTCCATATTG TACGCCCCAT TAAATTACAG TGTTTCTTAA
    TGAACTTGCA AAGGAATATT GCTAAAAACA AACAAAAAAA
    ACTGTTATCG AACTTTCTTT GTTGCTGCTA GTTAAAACTT
    GTTGCAACTT TTCACTTCTC TTGTGTCCAG GTATGCAGCA
    AAATTCTGCA ATTTCACCTT AAAGATACTG TTGGTTTTAC
    AGATGCTCTC CAACCTATTT TCTATAAGAT GAGGTAGTGG
    TGAACTCAGA TAACAAACTT CTCTTCTAAA CTGGTTCTGC
    TTCTAAGACA AGCATCTCCT GCCCTCTCTC CTTCCTCCCC
    ATCTCTCGCA CGCAGTCTAG AGATGGACTG AGCCTTGCTT
    CTCACTGGCA GTGTTGAGCT TTGGAGATGG GATGGTTGCT
    ATGCCAAGCC TTGTTTCTCT GCTCAGAAGA AGTAGAGAAG
    CTATTATCAA TTAAAAGCAT GCTGTGATGT GACTCCTGGA
    AGTGACGTAG GAGTGAGTGG CAGGTTGTTT GATTTAATAG
    GTATCTTAAT CAAGAATTAA GCTTGCAACA TTGGCTTTGC
    TCAGATGCAG ATGGAAGTGT GATCACAATC ATTTTGAATC
    CCTCTTCCTC ACTTTTTTTT CTAAGAAAAT AAACATTTTA
    CTGTTTTTAT GGATCCTTGT CTTCTCCCAT TCATCCAGCT
    CAGTGTTTTA AGATGATCCT GGGTGCAGAA GTTGAGCCCT
    CCTTTGCATT GACACTGATA ATTAGCCTAT AGGGCTCCCT
    ACCCTTCCAT TAAGAATCTA CCAAGCATTA GCAAGGCTGA
    AAGTGGTCTA AGAGGTGAGG GGACATCCTA TGACTTTTTA
    GGAAGGCCTG AAACCACCTT GTTACCTTTC ATTTTGTTAG
    CAAATAAACC ATCCTATTTT GTAACTCTCC CCCTTCAAAA
    TGCTACATGA GCCTTGCCAC TTCCTTTTTC TCTTACTTCC
    AGCACACTAG ACATAGCAAA AGTGTTTGCC TACTCAAAAA
    CATAATACTT TTATGCTGAT GATGGTATTT GGAGATGTGA
    AAGCCAAAAG CCCCTGGCAG TGGTGGGGAA TGTTGACTGA
    GTGTTCAGCA GAGTTTATTT TTCCATACTA TATGAAGAGA
    ATGATCTCTT CTCAAAGACA GAAGTGATAT TTTTAACAAA
    TATTGTCACA AGTAAATAGC AATCAAAAGG AGAAAATAAC
    TTTTGTATTT TTTTAATGTG TTTGATAGCT TTGACGAGGG
    TTCTCTTTGT TACTTTCAGG GGAGGGCATC CTATTAAATG
    CCACGCCAGC AGTCCGGGTC TGGGTTTGTC CCACAAAATC
    ACAGGAGCAC TGTATGTTCC TCTCTTTTGG AGTTGTGACT
    TTGAAGGGCC TCAATATTAG CCACACTGCC GCCTGCAGAA
    GGTGGAGAGT TAAGATGTTC TATGTCAATT TGCTCTTGCC
    GAAAAGATGA GCCTCGATTT TAAAATCTAT CCACATCCAA
    CTGATGGCAC CATTGATGTG CAAATAATGA GATTCCCTAT
    CTCCTTTTAG ACCTGGGACG GCAAAAGGGA AGGGAAGGAA
    ACTTAGCAGA GTGCTATTGA CTATAGATTC ACATATTAGC
    AACAAAATCC CGTAATTCTT TTGGCCAACA GCAGCTATTT
    TGGGGAGCAG CTGTGGCTGT TACATAAATA GAGATGCAGC
    CAAAATTTTA GGCCTTTTAT CCTGCTTCTA GCAGAAAAAT
    GCAGGGAGAG TCAAGTAGTC TAGGGTTTCA GGTTGCCTCC
    CCTCATATGG TTTTTGGCCA AGTGACTAAA ACAGTTTTCC
    ACAACTGTAA ACAAACTGCT AAGCCCCACC TCAAACTTGT
    TCACTGGGGA CTTTGCTTAC CGTTCTGTGG GTGACCTTTT
    CCGGGATTTC TTGTTCTTAT CAAGCAAGAA TTAAGCACAT
    GCTAAACGTC TTCCATTTGA CTTCTCTACT CGGTGTCTCA
    GACAGTGTCT TCCCAGAAAA CCACCACCCT CTACCCAAAG
    ATGAAACATG CTCATGTCAT TTTTCTCATG GTCACATTTA
    ACAGTTTTGA CATGTTATAC TTGCGCATAG ATCCAAGCGT
    TTCTTGGGAA CCTGACTTTT GAGTGTTTAA TAAAGCCGGA
    AGTGGTGTTG CCCTGAACCA GCAGATTTTC ACCTGGGTTC
    TGGCTCCGGT GTTTAACACT GGATACATCT TTGATGTGCG
    AAAGTGAGTT CATCTTCAGA CACATTTGGT ACATCCAGAA
    ATAGATCCAA GAAATGGGGT GGTTGAGTGG GTCCGCACGA
    AATGCTTGAT TATGTCAGCA ACACCCAACA CTGTCTGTTT
    TCCATTTGTT GGTTTTAATC ATAAAATTGT CAAGTGATTC
    GTGTTTGTAC TTTATTTTTT TGTGCCTTCT GAAAGGATCT
    AAAACAAAAA TATTTTGCCT TTTTTTCCCC ACGTGTATCT
    GAACATTAAG CAGATTGGCT CAGACACAAT GAAAAGGATA
    ATCCAATGTA CGTGCTGGTG CACTCTGCTA GTTGTTATCT
    CTGTAGGGCT CAGGAAGCTG GAAGGAGGAA GGGAGGGTAA
    GTGGCCTGGT GAGTGGAGGT AGAAAAATGA TGAGAAATGA
    ACTGAGAGCA TTAAGCAGAG AGGGTTGATA GGCTGGCCGT
    GTCCGGGGTG AAATTGGAAA TCCAGCTGCC TAGTGGCCAG
    TGGGTGGGGC AAGACTGTCA ACGAGATTTA CAGCTGGCTT
    ACACATGCCT TATGTCCTCT GAGTTGTAGA GTTGTAAAAG
    TTCAGCAGTG TGTGCACAGC TTTCTTTTGG TTGGCAGAGA
    TTCAGGATCA TGGAGTACTG CTCTCATAAT TGAAGACGTG
    TTTGTTATTG GCAGAGAACC TTAAAAAAGG CCTTTACCTC
    AGCGATGCTT CCTAGCCCCA GGCTTGCAGA GAACACAGAG
    TGGTGTTGTG GTCTATTTAG GGACAAAGAA GGTATAAAGT
    CCAGAGATGA GAAAACTGGG TCAGCCCTCA GAAACTGCAG
    CAGCCACGCA CACAGAAGCC TGCTGGAAGA CAGGTCTCTC
    TCCGTCCACA GTGCCCATCA TCTGAGCCTG GGCTGGGATG
    ACTCAACTTA GCAAAGACGG ACCCAGGAGG AGTGCTGGTT
    CTTCAGTCTT TGTACTGGCC CCATCCTCTC CTCACTGTAA
    TGTGAGGAAG CACCTCTGTG TCAGGGCTCA CCTGGGCATC
    CAAAGCGGCC ACGCCCACAA TCCGACAGCC CCCAGGAGCA
    GGTCCAGGGA TGATGCAGCC CCCTTCTTGG TCCCATGTGA
    TGTCATCCTG CTTTGTTATC TTCTTATAAC TTTATCCTGC
    TATAACTTTA TCCTCTTCCC AGCCTCATCC CTGTTTTTCT
    GTTAGGGCAA GACTCTTCCA TAAGCCTGCT AAAAAACAGA
    GATGATACCT CTTACAAACT TTACCTCATA GCCTGTGAAG
    CAGGTTGGCA TGTGGATTAC AAGTCCTGCT TTGACACTGG
    GCAAGAATTT AAGATTGTTC TATCTCTACT AGTCATAGAA
    AAGAAACATT GTTAAACATG TTGAGTTTTA AAGGAAGAAA
    TATTTTCAAA TTCTTAATCC AAGAAAATAC TGAGTTGGAA
    TCTTAGACTT CGGGACTCTG ACACGTTCTT TATGAAAGGC
    AAAATAATTG GTATCTAAAG TTCTCTCCTT CCTGCCTCCC
    CTAAAGAAAA AGGATATTAG ATTGCACACT ATAATTTTAC
    ATAAGATCTG CCTTCCACAC TTCCCTGCTG GAAGGCATTC
    TCAGAGCTTT ATGTCTTCGT ACCTCTCAGA GATTGGACTT
    TTTCTTGTTT AAAACCCCAA CCAAAAAAAA TAATAAGGCA
    TGATTGGTGG GGAGGGAATG TGTATTTAGG GGCATAATAA
    AAAGGTGGCT CGAAGCAGGA ACTTTGGCCT CATGGTGTCA
    TGGGTGGATG CCTGGACTCC AGTGTGCCTG TGAGGGGCTG
    GGTTAGGCAG TCGGCTGTCA CACTCACATG TGCCTGCAAT
    AAACCTTTTG GAATTTCATG AACGAGGTCT ATGAATTGCC
    TTTTGCCAAT GAATGGATGT ATTTTTCCAA GGGGGGAATA
    GTATCCTTGA CTTTGGCAGT CACCTTTTTG TATGTCTCTA
    GAAAGGGGTC AAAAAACTAT GGTAAAGATG AGGCTTATGA
    GTGAATACCT CTGGGACAAA CCTTAGGACT CACAAGCTAT
    GCCATGTTTT TCAGGAGACT CTTGTACCTT ATCTGGAATC
    TAATCTTGGG AGAAGAGGAA AAAGGAGCTA ATATTTGTCA
    TTTATACTCA CTCTGTGCCA GATACTGTGC TAGGCATTTT
    ATAATTGTTT TGTGTCATCC TCATGATAAT CCTGTGAAGT
    AGATCTATTA CCCCCGTGTT CTAAATAATA GATCTTAAGT
    GTGGAATGCA TCTATCCAAC ATAAATGCCC ATGTTGAAAG
    AAGGAAAGAT GTCATTCAAG TATTTTTCAA ATTCTTTTTA
    TTATGACTAT GCCCTTCGCA ACACTGTGAA AACAACCCCT
    GGGGGCATCT GCCTTCCAGA ATCTCTCTCT GGCTTCTCAC
    CAGCTTGGTT TCCTCATGGG GAGTGTTTTA TTTGGCCTCC
    CCTATCTGAG CTGCACACAC ACCAGGGGAG GCCACTGGCT
    AACAGTAGGA CTTCAGTGCC CTGAGGAAAA GGCTTTGGGA
    ATTTAGGCAC ACGTTTCTCT CCTTGGAATC CTTCTAGCAT
    CTGGAAAAGG AACCTGGTAT TTCTGCAGTT AGATACCAGA
    TGCAACCAGA ACAGGCTTTC GAGTGCTGTG ATTTCTTTCC
    TGGGTTCCCA AGTCTTGTTG TTTCATCACA AACTGTATCT
    TTTTAAGGTT AAAAGTCTTG ACCTTCATGG GGGTCTGGGA
    CAATCCGATC TCCAAGCATG GAGGAAAGGC AATGCCTGGA
    CCACTGACTT GCATTGAAAT CCTTTCTTGT GGGCTAGGGT
    TTGATGTCTC TTTTTCATCT TTGGACTGGG GATCTGCATC
    TTCCAGGTCC ATTTAAGCAC TGAAACTAGA TGCAAATCTC
    TTTCGAGACC TTACATGTTT TAGATAGTCA TGTAATGACT
    TGGATAGACA TTTAAATAAC TTGTTCCAAG GTCGGAAGAG
    CCCAAGAACT CCTCAGAGTT CCTCTTCTTG CTTCTTGAAT
    CACATCCTCT AAAGATGACT CATGTCTCCA TAGCAACTGT
    TAAAGGTGCT GCCTAGACGG GACCCGCTCC CACCTTTACT
    TACTTTGCTC GAAGGAACCA AAACAATGTC CTTGTGTAAA
    GGGGCTGTCA TATCCAGTTT TCCTTTGAAA TCTGGCCCCC
    AAGATCCTGC TTCTTTCTAA CCTGGCAGCT GTCATGTCCC
    TTCAAGATGA TGTGGGAAAT GGCCCTTACA ACTTGGGAAC
    CACAGAAATT GCTGTATTTC GGGAAGATTC ACCTCTAAAC
    TGAAGGCTTC ATTCTGATAG TGTCTGCCCT CTCTACCCTG
    ATTTCGCCCT TCTTTGCTTC CATTTTTAGC CCAAGGCTTT
    GAATTTGATT GAGTAAGACT TAGAGGCAGT ATAAAGAACA
    CCATAAACTT AGGCAGAGGT CCCTTAGGGT CTCTAGAGTT
    GAAAATAATT CTACAGCCTT AGGGGGACCT CTTGGCATTG
    ACTCTAAAGG GAGAGAATAG CCCCTGTGTC CTGGCATTTC
    AGTCTAGACC TTCAAGGACT GTTCTCTCTT GACAGGCAAG
    CAAGCAAAGA AAGTTTTGCA ATAGATTTCA AGCCAGTTTT
    TCCATTCAAA CCAAGATGCA AATTCATAAA ATTACTCTTT
    TCCTGGAATA GATCCAGGCA GCTGCCTTAT TAGAACTTTA
    GATTCGGATC TATTTTCTTA ACACACATAC ACATACACGC
    GCATACATAC ATATACAGAG AGATACGTGG AGAAAGGAAA
    TTTACTCTAT CATTGCAATA CTTCAAGAAA GAGCTGTATT
    TTGCCTTTCT GTAATCTCCA AGATAGTGTC TAGGAAAGTA
    ATAGTATAAC TATAGGGATA CCGAAACAGG AAAAACCAGC
    CATCACTCTT GAGAAAGTTT GAGTTCGACT CACATGGGAG
    AATCGAGGTC TGCTACTCGT CTTGCTTTGT GCCCCATCTG
    TGCCTGGATG CCCTACTACA TCTGCTTGAC TCGTCTGGGC
    TGCTAGCCGG GGTGTTGTGG CTGACATCCT TTCCTGGCCT
    TACACACATA ATAGACACAT CCCTAACGGC GTGTGCCTGG
    TCCAGCCACA TACAGCCACC ACATGTGTCA CACACTGTCC
    CCCTCATCCA TGTGGACTTG ACTGGCATTT CAGCAGCTCC
    ACTGGGATGC TCTAACCCCA GTGTGTGGAG TTGGGGTCCC
    TTCATCTAGG TTGACCCAGG TATAGCATTT TTAGCATTGC
    CTTTCCAGTC TTGATGATTC ATTCATTGAA CTCATTTATT
    TCTGGAGCCC CTGGTACACT CCAGGCACTG CGCTAATTGC
    CAGCAAAGCA CAACTGAACT AAATCCACCT TCAAGGAACC
    TAGCCATAAC GAGGGAGGCA GCATGGAAGT ACCCTACAGG
    GGAAAGTCCT GAGTGCTGTG GGAGCATCTC ACCGTGGCAG
    CCAGCCCAGT TTTGGCAATC AGGGGCTTCC TGAAAGAGGT
    GACATCAAAG CCCGGATGTG TCAGAGGACT GAGGGAGAGT
    GTTACTAAAG GACTTTCAGG CTGAGAGGAT AGCACAGGAC
    TCAGCCCAAA GGAGGGCCAG TGTGGACTGT CCAGGGCCAG
    CCTGCAGTAC AGAGGCTGGA GCTTGGACTT GTAGAGGGAG
    AGAGAAGAGC AAGGGACGTG GACGGGGCAG TGAGCCAGGC
    TAGCCACAGA GGGTTCCCGG GGCTTTGCTG GGGATTCAGG
    GAGCATAAAT AAGAGCTTTA GGTGGTGCTG TGTCCTCTGC
    AGCCCACTGC TGAGGTCCTC CAGACAGGTA AGGTGTGGTC
    ACAATCAGGG CCGGGGTTTC CCTGCTCACT GCGGCAGTGC
    AGGGGTGCTT GCTGAGATGA TTCATCCCAG GGTGTCCTCT
    GTCCCTTACC CAGCCCCAAC TCCTCTTCCT CTGCCAAAAG
    CTATTTGAAT TCAAGGACTT TAACCTGGGC CGGATCTGGT
    TTGGAGACAA AGGGGACAGC TCTGGGTCAG CATGACCTTC
    TTTAGAGCCA CTAAGGCGAA AAATACCGTT TGGGACCAGG
    CTGGCCTAGA CCCAGGGATG AGAATGCACC CTAAAATAAA
    TATACGGGAA GCAGCAGAGG GCTTCCCTGT CTAGTGTGTG
    ATCCTAACTA AAGGCAGCTC TCTTGGACAG CCTTCCCCTG
    GATTAGGTCA CATACACCTG GTGGCCAAGC CTCTGCTGGG
    TCCCAAATAC ACACCCGAGT CCTGCCAAAG AAAGGAGATT
    TTTAAAAAGC ACAGACAAAT TGTATGCAAG TGGAAAATAC
    CCATAGGCCT AGACAGCTGT GGAGGGAAGA CCTCGTGGGT
    ACCTGGAGGC TGCCAGAGCT GGGAGCTCTG CAGGTATGAG
    TCAGGGAAGG CTCAGAGACA AGCAGAATCT CTCTATGGAG
    ACAACTTGCA GTGCCTTTTA GGTTTTCCAA ATAACCTCGG
    AGTTCAGAGC ATTGGGTTTT TTTCTCCCCT CCCCACCCCC
    AGAAAAATAA TTAGAAAAAT GTTTAGGAGA AAGGAAAAGA
    ATTAGATGCA TCAGAATACC AGCTATAAGC CAACACTGTT
    TCCAGAAACT CAAGAAAAAG CTCAAACAGA AGACAGTTCC
    CCTGAGAGGC TGGAGGCGTT GGTGCTGAAG GCAATTTTCC
    TAGCTAAGGG GCACTGGGCC TTGCTGCACC TTGGGGCTGA
    CCTTTTTTGC AAAACACCCA CCCCTGCCCT CCTGGCATAC
    TCAACAGCAA CGCCAGCTTT CTGGACCCTT GGAAAGATGT
    TAGCTCAAAC ACCCACTTTT TCCAGATCTT CCTCTTGCTC
    TTCACTGAGG AATTTGTAAT TCTGAGGCTA GCGATGCCCA
    CTCGGATATT CCGCAGGCCC AGGTGTTTAG ATTAGAATTT
    GTCCAGCGGT AATCCTGATG CTGGAAACCA ACAAACATTT
    GGCCTCATAT TCACCCATTT AAAAACTAGA GCCCCTGGCA
    GGTCCCCTTA GGGCCATGTG TTCATGGAAT ATAAGCCAAG
    TTTGCCTTAG GCTTGTTCAT GGAATATAAG CCAAGTTTAC
    CTCTCCCCAT TTTCTGCCCT GGCCCACTTC CCACTCACCT
    CCACCTCATT GCCAGGAAGG GATCAAAATG CCTCCATGCC
    AGTTGTTAAT GGCTACATAT TTGCCCTTCC CAAGGGTATT
    TGCATTTTAT TTAGGAACAT GGCCTTATAT TCAAGGAAAA
    TCTAGCATCA AGATTACGAG GCATCACCTC TCAATCAGGT
    CTGGGAGGTA TCTTGGGGCA TTGCTCTTCT GAACACCTGC
    AGAGGCTTCC TCAGGTGAGT GTGGGAGCCC GGAAGGGTGG
    CCTCCCTAAC CACTCTGCCT GCACATGAAT TCTCCAAAGC
    AGTGGGCCCC CATCTGTTTC AATTACACAT GCCTGTCAGC
    AAAAACTTCG TGAGATGCAC TCTCTCTGTG TGTTTATTAA
    TTTATTTAAA GCATATATCC CTTTACTTTT GTACTACTAT
    ATTAGGCACA TTATAAAAAG TATACAGCAT AGAAACTTTA
    AATGAATAAG ACACAAAATA TTATAAACAG AGGTTCTGGC
    ATTTTCTCTC TGAACTCCTG AGGGGGACCT TGGGCACCTC
    CTGGTATGTG CACACCCCAC TTTGAACACC CTTGCTTTAG
    TGCAAATCAG CACGCCTAAA TAGCATCCCA AACCACTGTG
    CGACATTTGG CCTGCAGAAT AAGAAAGTCC TAAGGCAGAA
    TCCCCAGGAA CTTCAAATCT GGGAGATGAG GAAAGAAAAC
    TCACTCACAA ACAACATAAA TGTAAATAAT TCAAAACCCT
    AAAGGAGAGC TGTCCCTAGA CAGTAGTGGC TACAGGTGCT
    AAGCAAAAGT CAGGTACACT GGACAGAGCC ATGCGATTGA
    TTGTTCATCT TCCCTCTCTG GGTCTCCAGA AAAGGACACT
    GGCAATATCC CCAGCTCTCT CCTGATTGGA ATTCTTTGAA
    CCCTCGAAGT GCTCCAGCAG TACTACCCCC CACGTAGCAG
    TGGGCCCATG TCGCTTGAAT ATTATTTTTG ATTTGACCAC
    CAAGATGTAA TGATGATTCT ATTCCATTTT GAAAAGGGTC
    TGAGAAAGTG TACAGGTCTA ATTATATATA CATATTTATA
    CATGTGTATT TTTGTTTATT GTTACATTTT GACATTGGAC
    TTTCTATTAA ATAATTTTTA AGAGTTGG
    CFLAR NM_001127183.2 GACCACGCAT GGAGAATTTT ACCACCCAGA GACACGCGAG 4
    TGGCCCTGTG CAAGTTTCAA CTGCGCGGGG GGCGGGGAAT
    TCCGCAGACA GGATTCTAGA ATTTATGTCT TGTGTGGTAA
    CATTTCAGCC GGTGGGTGGC GGGGATTAGG CGTGAAGCGG
    TTCAGCAGGC AGAGGTTCTC GGACGCCCTC CGGCGAAGCC
    ACCTGTTGAT GCTTTTGACT TTCTGTCCTT GTTCCTCGTC
    CCATCTGGAG CATTTCCAAT TCTGGTTTTG CGGAGCAGCA
    GGTCTGAGCT TGTCCGGCGA GGGTGGGAGT TGGTCCCGGC
    GGAGATCCAG TGGGAAGAGC CGGCGGCTGC CCGGGCAACT
    CCCCCACTGG AAAGGATTCT GAAAGAAATG AAGTCAGCCC
    TCAGAAATGA AGTTGACTGC CTGCTGGCTT TCTGTTGACT
    GGCCCGGAGC TGTACTGCAA GACCCTTGTG AGCTTCCCTA
    GTCTAAGAGT AGGATGTCTG CTGAAGTCAT CCATCAGGTT
    GAAGAAGCAC TTGATACAGA TGAGAAGGAG ATGCTGCTCT
    TTTTGTGCCG GGATGTTGCT ATAGATGTGG TTCCACCTAA
    TGTCAGGGAC CTTCTGGATA TTTTACGGGA AAGAGGTAAG
    CTGTCTGTCG GGGACTTGGC TGAACTGCTC TACAGAGTGA
    GGCGATTTGA CCTGCTCAAA CGTATCTTGA AGATGGACAG
    AAAAGCTGTG GAGACCCACC TGCTCAGGAA CCCTCACCTT
    GTTTCGGACT ATAGAGTGCT GATGGCAGAG ATTGGTGAGG
    ATTTGGATAA ATCTGATGTG TCCTCATTAA TTTTCCTCAT
    GAAGGATTAC ATGGGCCGAG GCAAGATAAG CAAGGAGAAG
    AGTTTCTTGG ACCTTGTGGT TGAGTTGGAG AAACTAAATC
    TGGTTGCCCC AGATCAACTG GATTTATTAG AAAAATGCCT
    AAAGAACATC CACAGAATAG ACCTGAAGAC AAAAATCCAG
    AAGTACAAGC AGTCTGTTCA AGGAGCAGGG ACAAGTTACA
    GGAATGTTCT CCAAGCAGCA ATCCAAAAGA GTCTCAAGGA
    TCCTTCAAAT AACTTCAGGC TCCATAATGG GAGAAGTAAA
    GAACAAAGAC TTAAGGAACA GCTTGGCGCT CAACAAGAAC
    CAGTGAAGAA ATCCATTCAG GAATCAGAAG CTTTTTTGCC
    TCAGAGCATA CCTGAAGAGA GATACAAGAT GAAGAGCAAG
    CCCCTAGGAA TCTGCCTGAT AATCGATTGC ATTGGCAATG
    AGACAGAGCT TCTTCGAGAC ACCTTCACTT CCCTGGGCTA
    TGAAGTCCAG AAATTCTTGC ATCTCAGTAT GCATGGTATA
    TCCCAGATTC TTGGCCAATT TGCCTGTATG CCCGAGCACC
    GAGACTACGA CAGCTTTGTG TGTGTCCTGG TGAGCCGAGG
    AGGCTCCCAG AGTGTGTATG GTGTGGATCA GACTCACTCA
    GGGCTCCCCC TGCATCACAT CAGGAGGATG TTCATGGGAG
    ATTCATGCCC TTATCTAGCA GGGAAGCCAA AGATGTTTTT
    TATTCAGAAC TATGTGGTGT CAGAGGGCCA GCTGGAGGAC
    AGCAGCCTCT TGGAGGTGGA TGGGCCAGCG ATGAAGAATG
    TGGAATTCAA GGCTCAGAAG CGAGGGCTGT GCACAGTTCA
    CCGAGAAGCT GACTTCTTCT GGAGCCTGTG TACTGCGGAC
    ATGTCCCTGC TGGAGCAGTC TCACAGCTCA CCATCCCTGT
    ACCTGCAGTG CCTCTCCCAG AAACTGAGAC AAGAAAGAAA
    ACGCCCACTC CTGGATCTTC ACATTGAACT CAATGGCTAC
    ATGTATGATT GGAACAGCAG AGTTTCTGCC AAGGAGAAAT
    ATTATGTCTG GCTGCAGCAC ACTCTGAGAA AGAAACTTAT
    CCTCTCCTAC ACATAAGAAA CCAAAAGGCT GGGCGTAGTG
    GCTCACACCT GTAATCCCAG CACTTTGGGA GGCCAAGGAG
    GGCAGATCAC TTCAGGTCAG GAGTTCGAGA CCAGCCTGGC
    CAACATGGTA AACGCTGTCC CTAGTAAAAA TACAAAAATT
    AGCTGGGTGT GGGTGTGGGT ACCTGTATTC CCAGTTACTT
    GGGAGGCTGA GGTGGGAGGA TCTTTTGAAC CCAGGAGTTC
    AGGGTCATAG CATGCTGTGA TTGTGCCTAC GAATAGCCAC
    TGCATACCAA CCTGGGCAAT ATAGCAAGAT CCCATCTCTT
    TAAAAAAAAA AAAAAAGGAC AGGAACTATC TTACTCAATG
    TATTAGTCAT GTTTCTCTAG AGGGACAGAA CTAATAGGAT
    ACATGTATAT AAAAAGGGGA GTTTATTAAG GAGTATTGAC
    TCACATGATC ACAGGGTTAG GTCCCACAAT AGGTCATCTG
    CAAGCAAGGA AGCCAATTCA AGTCCCAAAG CTGAAGAACT
    TGGAGTCCAA TGTTTGAGGG CAGGAAGCAT TCAGCATGAG
    AGAAAGATGG AGGCCAGAAG ACTACACCAG TCTAGTCTTT
    CCATGTTTTG CCTGCTTTTA TTCTGGCAGT GCTGGCAGCT
    GATTAGATGG TGCCCACCCA GATTGAGGAT GGTCTGCCTT
    TCCCAGTCCA CTGACTCAAA TGTTAAATCT CCTTTGGCAG
    CACCCTCACA GATGTACCCG GGAACACTTT GCATCCTTCT
    ATTCAATCAA GTTGATACTC AGTATTAACC ATCACAGTCC
    ATTTGGGCAA CTATACCAAA TTACCATAGA CCAGGTGACT
    TAAACAGCAG TTATTTCTCA CAGTTCCGGA GGCTGGGAAA
    TCCAACATCT AAGTGGTAGC ATATCTGGTG TCTGGTAAGG
    CATGCTTCCA GATCTTACCA GATGTCAGTC TTTTGATGTT
    CTCACATGGC AGAAAAAGAG GATGCAAACT CTCAAGTATA
    TCTTTAAGGG CACAAATTCC ATTCATGAGG GCTCTACCCT
    CATCACCTAA TTACCTCCCA AAGGCCCCAC CTTCTGATAC
    TGTCACTTTG GGGATACTGT CTCCCCTTTG AATTCTGGGG
    GGAATACAAA CATTCAGTTT GTAACAATAG CCTTATGATT
    TAGAGGTTAC TTGTTCATTC ACCTAGACCT CAAATTGCAT
    TTTACAGCTA GTCAAGTATA TCTTTCTCTG ATTTGATAGT
    GTGACCTAAA AGGGGACCAT TGTTTGAAAT ATCATTAGAG
    TTGCTTATTA TTATTATTAT TATTATTATT ATTATTATTA
    TTATTATTAT TGAGACAGAG TTTCATTCTG CTGCCCAGGC
    TGGAGTGCAG TGGCATCATC TTGGCTCATT GCAACCTCTG
    CCTTCTGGGT TCAAGCGATT CTCCTGCCTC AGCCTCCCGA
    GTAGCTGGGA TTACAGGCTC CTGCCACCAC ACCCGGCTAA
    TTTTTGTATT TTTAGTGGAG ACAGGGTTTC CACCATGTTG
    GCCAGCGTGG TCTTGAACTC CTGACCTCAG GTGATTCACC
    AGCCTCGGCC TCCCAAAGTG CTGGGATTAC AGGTGTGAGC
    CACTGCACCT GGCCTATTAT TATTTTTAAA TTTTTTTTTT
    TTAATTGATC ATTCTTGGGT GTTTCTCACA GAGGGTGATT
    TGGCAGGGTC ACAGGACAAT AGTGGAGGGA AGGTCAGCAG
    ATAAACAAGT GAACAAAGGT CTCTGGTTTT CCTAGGCAGA
    GGACCCTGCG GCCTTCCGCA GTGTTTGTGT CCCTGGGTAC
    TTGAGATTAG GGAGTGGTGA TGACTCTTAA GGAGCATGCT
    GCCTTCAAGC ATCTGTTTAA CAAAGCACAT CTTGCACTGC
    CCTTAATCCA TTTAACCCTG AGTGGACACA GCACATGTTT
    CAGAGAGCAC AGGGTTGGGG GTAAGGTCAT AGATCAACAG
    CATCCTAAGG CAGAAGAATT TTTCTTAGTA CAGAACAAAA
    TGAAGTCTCC CATGTCTACT TCTTTCTACA CAGACACAGC
    AACAATCTGA TTTCTCTATC TTTTCCCCAC CTTTCCCCCT
    TTTCTATTCC ACAAAACCGC CATCGTCATC ATGGCCTGTT
    CTCAATGAGC TGTTGGGTAC ACCTCCCAGA CGGGGTGGCG
    GCTGGGCAGA GGGGCTCCTC ACTTCCCAGA TGGGGCGGCC
    AGGCGGACGC GCCCCCCACC TCCCTCCCGG ACGGGATAGC
    TGGCCGGGCG GGGGCTGACC CCCCACCTCC CTCCCCGACG
    GGGCGGCTGG CCGGGCGGGG GCTGACCCCC ACGCCTCCCT
    CCCGGACGGG GCGGCTGCCA GGCGGAGGGG CTCCTCACTT
    CTCAGACGGG GTGGCTGCTG GGCGGAGACG CTCCTCACTT
    CCCAGACAGG GTGGCTGTCG GGCGGAGGGG CTCCTCACTT
    CTCAGACGGG GCAGCTGCGG GCGGAGGGGC TCCTCACTTC
    TCAGACGGGG TGGCCGGGCA GAGAAGCTCC TCACATCCCA
    GACGGGGGGG CGGGGCAGAG GCGCTCCCCA CATCTCAGAC
    GATGGGCGGC CGGGCAGAGA CGCTCCTCAC TTCATCCCAG
    ACGGGGTGGC GGCCGGGCAG AAGCTGTAAT CTCGGCACCC
    TGGGGGGCCA AGGCAGGCGG CTGGGAGGCG GAGGCCGTAG
    CCAGCTGAGA TCACACCACT GCACTCCAGC CTGGGCAACA
    TTGAGCACTG AGTGGACGAG ACTCTGCCCG CAATCCCGGC
    ACCTCGGGAG GCCGAGGCTG GCAGATCACT CGCAGTCAGG
    AGCTGGAGAC CAGCCCGGCC AACACAGTGA AACCCTGTCT
    CCACCAAAAA AATACGAAAA CCAGTCAGGC GTGGCGGCGC
    CCGCAATGGC AGGCACGCGG CAGGCCGAGG CGGGAGAATC
    AGGCAGGGAG GCTGCAGTGA GCCGAGATGG CAGCAGTACA
    GTCCAGCTTC GGCTCGGCAT CAGAGGGAGA CCGTGGGGAG
    AGGGAGAAGA GAGGGAGGGG GAGAGGGCTA TTTTTAAAAT
    TTTTTAAAAT TGCTGAACAG GGGTACCTCT GGGCAGTGTG
    TCAGAATACC ACTTTTTAAA TATTTTATGA TTTATTTATT
    TTTCTATTTC TTGAGGTTTT AACTGATGTG TATCTGTATG
    TCTATTTGTG TATATTTTGT CATGATCATG TAACAGAGTC
    TGAAAAGTGT CGAAGAGACA GTTTTCAGGA ACAACAAGCA
    ATTATTCCTA CTTTCCAAGT TATTTTGATG CCATGGTGGC
    TCATACCTAT AATCTGAGTA CTTTGGGAGG CTGAGGTGGA
    CTGATCACTT GAGCCCAGGA GTTTGAGACC AGCCTGGGCA
    ACATAGCAAG ACTCCATCTC TACAAAAAAA GACAAAATTT
    AGCTGAGCGT GGTGGCGTGT TCCTGTAGTC CCAGCTACTT
    GGGAGGCTGA AGTGAGTGGA TCCCCTGAGC CCAGAGAGGT
    CAAGGTTGTG ATGAGCTGTG ATCACACCAC TGCACTTCAG
    CATGGGAGAC AGAGTGAGAC CCTGTTTCAG AAAAAATAAA
    TAAATAAAAC CACCAGCACC ACAAACAACA ACAAAAAGTT
    ATTTTGTACT TGTTTTGAGC ACAGGACTCC TGAGGGTATC
    TTTGCATTTA ATATTACATA GGGGTGCCAG TGGGAAGTAA
    TGTGTATGCT TGGCCTCATG AGCTAAAACC CTGTGTTAAT
    TATGACAGAA GGAAAGTGTG TGAGAGAGAT CTTAACTACC
    TAGCAGCTCT AGCTGCCATC TTGAACCATG AAGATACGGG
    CCACACGTAG GGGTAGCTGG GTAGTGAGCA GCAAGAAGCC
    TTGTTGGATG AGGGCACGAA GGAGCAGAAT CACTGGAATC
    ACTGTGTCAG CCCTAATTAC CTACCTCTGG ACTTTTATGT
    GAGGGGAAAA AAAATTGACA GTTTATATTT ATCTCAACCT
    AGTTAACCCA AGTGATGCAT TGTTATGAGA TTAAAATGTT
    TGGAGGCCGG GTGCGGTGGC TCACGCCTAT AATCCCAGCC
    CTTTGGGAGG CCAAGGCGGG CGGATCACGA GGTCAGGAGA
    TCAAGACCAT CCTGGCTAAC ATGTAAAACC CCGTCTCTAC
    TAAAAATACA AAAAATTAGC CAGGCGTTGT GGCGGTCGCC
    TGTAGTCCCT GCTATTTGGG AGGCCGAGGC AAGAGAACGG
    CATGAACCTG GGAGGTGGAG CTTGCAGCGA GCTGAGATCT
    TGCCACTGCA CTCCAGCCTG GGCGACAGTG CGAGACTCTG
    TCTCAAAAAT AAATAAATAA ATAAATAATA AATAAAATGT
    TTGGAATGTT GGCTTCATCC CTGGGATGCA AGGCTGGTTC
    AACATACGCA AATCAAGAAA CATAATTCAT CACATAAACA
    GAACTAAAGA CAAAAACCAC ATGATTATCT CAATAGATAC
    AGAAAAGGCC TTCAATAAAA TTCAACGTTG CTTCATGTTA
    AAAACTCTCA ATAAACTAGG TATTGATGGA AAATATCTCA
    AAATAATAAC CATTTATGAC AAACCCACAG CCATTATCAT
    ACTGAATGGG CAAAAGCTGG AAGCATTCCC CTTGAAAACT
    GGCACAAGAC AGGGATGCCG TCTCACCACT CCTATTTAAC
    ATAGTATTGG AAGTTCTGGC CAAGAAAATC AGGCAAGAGA
    AACAAATAAG GGGTATTCAA ATAGGAAAAG AGGAAGTAAA
    ACTGTGTTTG CAGATGACAT GATACTATAT CTAGAAAACC
    CCATTATCTC CACCCAAAAG TTCCTTAAGC TGATAAGCAA
    CTTCAGCAAA GTCTCAGGAT ACAAAATCAA TGTGCAGAAA
    TCACAAGCAT TCTATACACC AACAATACAC AAGCAGAGAG
    CCAAATCATG AATGAACTCC CATTCACAGT TGCTAGAAAG
    AGAATAAAAT ACCTAGGAAT ACAGCTAATA AGATGTGAAG
    GATCTCTTCA AGGAGAACTA CAAACCACTG CTCAAGGAAA
    TAAGAGAGGA CACAAATGAA AAAACATTCC ATTCTCGTGG
    ATAGGAAGAA TCAATATCAT GAAAATGGCC ATACTACCCA
    AAGTAATTTA TAGGTTCATT GCTATTCCCA TTAAACTACT
    ATTGACATTC TTCACAGAAT TAGAAAAAAA CTACTTTAAA
    ATTCAAATGG AACCAAAAAA GAGCCCGTAT AACCAAGACA
    ACAATAAGCA AAAAGAACAA AGCTGGAAGC ATCACACTAC
    CCAACTTCAA AGTATACTGC AAGGCTACAG TAGCCAAAAT
    GGCATGGTAC TGGTACAAAA ACAGACACAT AGACCAATGG
    AACAGAATAG AGACCAGAGA AAGAAGACCA CACATCTACA
    GCCATCTGAT CATCGACAAA CCTGACAAAA ACAAGCAATG
    GGGAAAAGAT TCCCTATTTA ATAAATGGTG CTGGGAAAAC
    TGGCTAGCCA TATGCAGAAA ATTGAAACTG ACCCCTTCCT
    TACACCTTAT ACAAAAATTA ACTCAAGATT AAAGACTTAA
    TGTAAAACCT AAAACTATAA AAACCCTAGA AGAAAATCTA
    TTTAATACCA TTCAAGACAT AGGCACAAGC AAAGGTTTCA
    TGACAAAAAC ATCAAAAGCA ATTGCAACAA AAGCAAAAAT
    TACAAATGGG ATCTAATTAA ACTAAAGAGC TCCTGCACAG
    CAAAAGAAAC TATCATTAGA GTGAACAGGC AACCTACAGA
    ATGGGAGAAC ATTTTTGCAA TCTATCCATC TGACAAAGGT
    CTAATATCCA GAACCTACAA GGAACTTAAA ACAAATTTAC
    AAGGAAAAAA ACAACCCCAT CAAAAAGTGG ACAAAGGACA
    TGAACAGACA CTTCTCAAAA GAAGACATTT ATGTGGCCAA
    CAAACATATA AAAAAAAGCT CAACCTTACT GATCATTAGA
    GAAATGCAAA GGAGAACCAC AATGAGATAC CATCTCATGC
    CGGTCAGAAT GGTGATTATT AAAAAGTCAA AAAACAACAG
    ATGCTGGCGA GGCTGTGGAG AAGTAGGAAC ACTTTTACAT
    TGTTGGTGGG AATGTAAATT AGTTCAACCG TTGTGGAAGT
    GTGTGTGGCT ATTCCTCAAA GATCTAGAAC TAGAAATACT
    ATTTGTCCCA GCAATCCCAT TACTGGGTAT ATACCCAAAG
    GAATATAAAC CATTTTATTA TAAAGATACA TGCACATTTT
    TGTTCATTGC AGCACTCTTC ACAATAGCAA AGACACAATA
    GCAAATGCCC ATCAAAGATA GACTGGATAA AGAAAATGTG
    GTACATATAC ACCATGGAAT ACTGTGCAGT GCAGCCATTA
    CAGCTTTTGG TGATACAGTG AATCAGATTT TTCATTAATT
    CTTTTAATTG GTTATTACTG AACGTGAAAA AGTAATGTTT
    GTATTGAAAT CTTGAGTCTG GCCATGTTTC TATTTTAAAT
    TCATAAAGAA TTCTAACAAG AGGAATTCCA AGAATGTCAT
    AAATGGATGT TTCTCCATGG ATGAAGGAAC TGTTTTATTC
    ACTTGCTGAT AATTCAGCCT AATCCAGTTT GACATCATAT
    AGATAAGTAG TTGAATTATG GATTTAAAAT ACATATCATT
    TTCTAACTCC AAAGGTAATA CTTATTTAAA TGGTTTTGAA
    AATATAGAAA GGCACAATTT CTTTTTAAAT CTGTTATTCT
    CCACCACCAC TCAATCTGTC TATCATCTAT CTCTCCATTC
    ATTCTTCCAT TTGTTTATAT CTGTTAATCT TTGTATGTGT
    TCATGTATAG CTTTTACATG ATTGGAATCA TAATGCATAT
    TCCATTTTGA AGTCTGCTTT TTTTTACACA AAAATATGTT
    GTGAATATTT TCCTATATTA TGAAATATCA TTAGCTGAGC
    TTTTAGAATT GACTGCATGT TTTGGTACCA TTTAGATATA
    GTTTAAGATA CTTAGAAGTT ATGTGGCTTT GCCACTATGG
    ATGAATCTTA TTTACTCAAT ATTAATTACT TACAAATAAC
    CTCACCTAAA CACTACTCAG CCATAAAAAG GAATGAATTA
    ATGACATTCA CAGCAACCTG GAGACTATTA CTCTAAAGGA
    AGTAACTGAG GAATGGAAAA CCAAACATTG TATGTTCTCA
    CTCATAAGTG GGAGATAAGC TATGAGGATG CAAAGGCATA
    AGAAGGATAC AATGGACTTT GGGGACTTAG GGGAAAGGGT
    GGGAGGGGGG TGAAGGATAA AAGAATACAA ATTGGGTTCA
    GTGTATACTG CTCAGGTGAT GGGTGCACCA GAATCTCACA
    AGTAACCACT TAATTACTTA CGCATGTAAC CAGATACCAC
    CTGTTCCCCA AACACCTATG GAAATAATTT TGTTTTTTTT
    TTTAAAAAAG GAATGAGATC ATGTCCTTTG CAGGGACATG
    GATGAAGCTG GAAGCCATTA TCCTCAGCAA ACTAACAGAG
    GAGCAGGAAA CCAAACACCA CATGTTCTCA CTTGTAAGCG
    GAAGCTGAAC AATGAGAACA CACGGACACA GGGATGAGAT
    CAACACACAC TGGGGCCTGA TGCAGGGGCC GTAGCGGGGA
    GAGCATCAGG ATAACTAGCT AATGCATGTG GGGCTTAATA
    CCTAGGTGAT AGGTTGATAG GTGCAGCAAA CCACCATGGG
    ACACGTTTAC CTATGTAACA AACCCGCACA TCCTGCACTT
    GTATCCAGAA CTTAAAATAT TTTAAAAATC TTTAGAGAAT
    ACAAAAAAAA AAAAAAAGAT TCTTCAATGC ATACACAATA
    AAATTGCAGT TCAGTCAAAC ATTGGAAGTC TTTCTCTGAC
    TGTCTAGTTG GTATCTTCAT TTTCAGCTTC TTCAAGATCC
    CACTCCAAAC ACTGTTAGCT CAGCCAAATT GAACAGCTCA
    TATCTCCTAC CTCTGGATCT TTGGTTCTGG TGATTGTATA
    TTTCTGGACC ATCTGGAACC CCAGCATATC ACCCTACCCC
    ACATCTCCAC ATCCCCAAAA TATAACCATA CTTCAAGGGC
    AGTTCAAATA CCATCTCCTT CTATCCTCCA TGAAGTCAGT
    TATCTCTTCC ATTGGAATTA TCGCCCCCTC TCCTGAACAG
    TACTATTTCG TGTGAATCTC CTCCAAGCCT TCTTTTCATT
    TTATATCTCA TGCTGTAATT CTTGGAAAGT ATGCTGTAGC
    TCAAGTGCAG AATTCTCATC AGTTTTATCT TTATATCTCT
    CCTAAACACT TTACCTGATG AAGAGCCTGG CATACACATA
    AATATATATT GAATGAATCA GTGATGGATT GAAAAGAGAA
    ATGATGGATC TCCTAAATTT TAACTTTTAT AAAATATTTT
    GATACATTCA TGACCTTACT TTAGCAAGCA ATGAACGTGA
    TGTAAACTAT TGTTGATATA GTTTTTATAT TGGAAGTGTA
    AGTAGTTTGT GGCATGGGAT TGTGACATAT CCTAGGTTTC
    CTCATCTTCT TTTTATTGAA ATGTAATTCA CAAGCCATAA
    AATTTGCCCC TTTAAAGTAA ATGATGCAGT GGATTTTAGT
    ATATTTACAG AGTTGTGCAA TCATCACCAC TATCTAATTC
    CAGAACATTT CCATCTACCT AGAAACTCCA TACCAGTGAG
    CTGCCACTCT AATCCTCCTC TTCCCCCAGC CTCTAGAAAC
    AATAATCCAT TTTCTGTCTC TATGATTTGC CTGTTCTAGA
    TATTTTATAA AAATAAACAT GTGGCCTTTC GTGTCTGACT
    TCCTTCACTT AAAAAAAAAA AAAAAAAA
    CFLAR- NR_040030.1 CATGCATACA GCCCAGTCTA ACGTACAGGA TCAAAAAGAG 5
    AS1 ACCTTATTTC GGCTGGCAAT TACCTTACCC GCTTGTTCAT
    TATCTGACTC CTGCACTCCT CCCAAGTGTT CAATGTTAAC
    CAGATGGCAA AGTTAACCAG ACAGAGGAAA TCCACATAAT
    TACTCTAGAT GAAGCCCCCT AACTGCGGAT TAGAAGGAAA
    AGAGATGAAG GGTGCTGCAC TAATAATAAC AACCATTTTC
    AACCAAGGCA GGATTCTGGG CCTAGAATCT TCAGTGACAA
    ATTACCAGGA GAGGAGGAGG GAAATGAAGA GCTGGAGGCC
    TAGGGAGATG GTGTGAGGAG AGGAGACTGT GCCTTTCCAC
    TTCTTAATAA TTAATGTTCT CCTGCTGCTC TGAGTCTGCA
    TCACCAGTGA TTCAGTTTGA GTCAGACATC CAACAACAAC
    TGAGCAAAAG AATCATCTCA GATCCAAGCA ATGGTGACGC
    GCAGATAGAA GAGACTGAGG CCAACGACCA AAGCAAAGGA
    CAGCAGAACT GACTGACACA GCTCAGAAAA TATCCAAAGC
    TCTGTATGCT CTGGAAAGGA AGACAAGAAA TGCTAAAGAC
    TCTGGATATT GCTCTGTTTC TATAAGGTCC CACCCATATA
    CCATCTCTTC TTTTGGATTT CCTTTGGCAG GGTTCCCTTG
    TATGGAAGTT CTCAGGAGAA CAACACTCTC AGAGTCCCAC
    TGTCTCAAAG AATTCTTAAT GGACAGCTAT ACTTGGCCCC
    AAGGTTTCAA CCTCACACTG AAGAAAGTGA CATAAGAAAA
    CACAAGTCCC AGTGCTATCA GGGGCTATCT GGAAAAGCTG
    CTTAAACAGC AAGTGAAAGA AGGCTCTCCC CTACCCCGTT
    CTAGACTCAC CCTGAAGTTA TTTGAAGGAT CCTTGAGACT
    CTTTTGGATT GCTGCTTGGA GAACATTCCT GTAACTTGTC
    CCTGCTCCTT GAACTATAAA AGCAGAAGGG AGGTACTGAG
    TTAAAACTTA CAAATTATTA TCAAATAAAT CTTCAATAGT G
    CHP1 NM_007236.4 ACCACCCCTG GGTTCCCTCC CGGGTCCGCA GTGGAAACAC 6
    TGCCCTCTCC CTTCTTGACC CCTAGCCCTT CCTTCCCTCC
    CTCCTTCCCT CCTGTCGCCG TCTCTTCTGG CGCCGCTGCT
    CCCGGAGGAG CTCCCGGCAC GGCGATGGGT TCTCGGGCCT
    CCACGTTACT GCGGGACGAA GAGCTCGAGG AGATCAAGAA
    GGAGACCGGC TTTTCCCACA GTCAAATCAC TCGCCTCTAC
    AGCCGGTTCA CCAGCCTGGA CAAAGGAGAG AATGGGACTC
    TCAGCCGGGA AGATTTCCAG AGGATTCCAG AACTTGCCAT
    CAACCCACTG GGGGACCGGA TCATCAATGC CTTCTTTCCA
    GAGGGAGAGG ACCAGGTAAA CTTCCGTGGA TTCATGCGAA
    CTTTGGCTCA TTTCCGCCCC ATTGAGGATA ATGAAAAGAG
    CAAAGATGTG AATGGACCCG AACCACTCAA CAGCCGAAGC
    AACAAACTGC ACTTTGCTTT TCGACTATAT GATTTGGATA
    AAGATGAAAA GATCTCCCGT GATGAGCTGT TACAGGTGCT
    ACGCATGATG GTCGGAGTAA ATATCTCAGA TGAGCAGCTG
    GGCAGCATCG CAGACAGGAC CATTCAGGAG GCTGATCAGG
    ATGGGGACAG TGCCATATCT TTCACAGAAT TTGTTAAGGT
    TTTGGAGAAG GTGGATGTAG AACAGAAAAT GAGCATCCGA
    TTTCTTCACT AAAGGAGACC AAACTGTTCC TTGCGGTCTA
    GTATTTAAGA ACTGGAACTT GAAAGTCCTC CTTCTACCAA
    CTCCACCTCC ACCCCCTCAT TCCCCTTCTC CCAAAGTACT
    ACTGCTGTTG CATGACAACC CCAAATATGT TCTGTCAACA
    CAAACCTGCC TTTGGTGTAT AAACAGGGCA TTACAGAATG
    GTACACCCTA TATATTTCTG TTCAGTATCC ATTCACTAGT
    TCTTCATTTA TAAATATCAT CTTCCCCATT CTGCTGCTGA
    ATGCCACACA TCCATCCAGT CTGAGAAAGT GAGAGAGGCA
    ATCATGCCAA GAACAAGCCA GCAAAGCTCT TTCACCAGAT
    GTAGACTGTA GCCCTGCTGC CTTCCCTCCA GCGAGTCTGC
    CAGCATGCTT CTTCATCCTT TTTATATGTT CTTTGCTTCC
    TACTTCCCTG TCTTCCAACA TACTGTTCAC TTACTCTGGC
    AGTCTTTCTG CTTTTCATTA AGCCTCAAAA TCTCCTCTGT
    TCTACTTGGC ACCACAAGCT ATGTCCTATA TATGTATTTC
    TGACTTGGCA GGATAGTTCA GGGGTCTGGC AGTTTTTATT
    TACCTTCATT ATTAAATGGG CCTCTGGGAT GTTGCCTCTT
    CAGGAGCTTT TTGGTAATCA ATACTTCTCT CAGAAGTATG
    AGACCATCCT CTGCACTCTG CTCTGTCATC AAAGGCTGCT
    GGGTGGAGAT ACCCTTTTTG AAAGGTGGCC TTGGTGAGAG
    GTATGGAGCC AAGTCTTCTA GGTTGCTTGC CCACATCACT
    CTATCTCTGG CCTCTGATTC TCAACTTTGT ACCTGTGTGG
    CTCCTCTTGT TAGTGCAATG TTGACTGTTG AAAAAGCAGC
    AGTATGCTTA CAGGTTTGCT TAGTTTGGGG ACACCGTTAC
    CACCAGAATG GCTGCTCTGA CAATATGCCT AGGGACTTTC
    TCATGGCTTT TATTTAATAA GGAGGCTGGG CACCCTATAA
    AGCCTCATGC ATTCACACCT TTGCAGCATG GTTTATGCCT
    CAGTGTTATG TGCACTGGAA TGTTTTCCAC TTCACATTTC
    CAAGTAGAAA TATTAGTGTT ACGGAAGTGC CTAATATCCC
    AGTCCAAATT TTTTTTTTTT TTTTTTTTTT TTTTTGAGAC
    AGAGTCTTGC TCTGTCACCC AGGCTGGAGT GCAGTGGTGC
    GATCGCTCAC TGCAACCTCA GCCTCCTGGA TTTAAGTGAT
    TCTCCTGCCT CAGCCTCCCA AGTAGCTGGG ATTACAGGTG
    TGCACCACCA TGCCCGGCTA ATTTTTTGTA TTTTTAGTGG
    AGACAGGGTT TCACCATGTT GGCCAGGCTG GTCTCGAACT
    CCTGACCTCG TGATCCGCCT GCCTCAGCCT CCCAAAGTGC
    TGGGATTACA GGTGTGAGCC ACCACGCCTG GCCCCAGTCC
    AAAATATTTA AAGATTGTTT CCTTAGTGTC TTGAAGTTTT
    GCACAAAATT CTTTTTTTTG AGATGGAGTC TCACTCTGTC
    ACCCAGGCTG GAGTGCAGTG GCGTGATCTT GGCTCACTGC
    AACCTCTGCC TCCTGGGTTC AAGCAATTCT CCCACCTCAG
    CCTCCCAAGT AGCTGGGATT ACAGACGTGT GCCACCATAC
    CTGGGTAATT TTTGCATTTT TAGTGGAGAG GGAGTTTCAC
    CATGTTGGCC AGGTTGGTCT TGAACTCCTG ACCTCAGGTG
    ATCCTCCTGC CTCGGCCTCC CAAAGTGCTG GGATTACAGG
    CATGAGCCAC CGTGCTCAGC CGCAAAATTC TTTATGAATT
    TTACACTTGG CAAATGTTAA TGACGGAAGC CATAGTCTGC
    TCCTAATACA TGTCCAAAGC ATTGACTGTT GTGTCATTAG
    CTGCCTGGTT ACATTAGCTC CCTGGCTTCT TGTTTAGACC
    ACTGCTAATC CCTTAAAAAC AAGAGGTCTG GCACTAGTAG
    CACAACCTAA GGTGGCATTA CAGATCTTTG AGCGAGCCAC
    AGCAACTTTT CTGCCAAGTC AGCTTAGTTT AGACTTCAGT
    GAATCAGGCT ATTGCTATCC TAATGTATGT CTCTATGAGT
    GTATTTAGCC ACACATCTGC CCTTGGTTGA CTTTCTGACT
    CATTGCTTGC TTGCTTGTTT CCTTGCTTTG GAAAACTATT
    GAAGATTGCT AAAAAATACC ACTGCAAAGT GATGGAAAAG
    GGTGGAGAAC AGGGGAGTAG CCAGGCTGGA TGGCTCAAAT
    ATAAATGAAT GAGGAATTCT TTATGAAGTA TCAGTCAGAT
    TTTATGATTA AGTGATGTAA TATAGGAATT ATGTAAAAGG
    GAAGAATGTC TGATACTGAT CTATTAGAGA GGTACTTTAG
    AGGCTTCTTG ATTGGCATAA AGTTCCTAAG GTTATAGATT
    TTCCCCCCTT TTGGCTGTAT AGCAAAGTGT TTTAATCCAC
    GGTTGTGCCT TATTGTTCCA TTAAAATTGT ATCTTCGATC
    CATCAATAAA TACTTGTGGT TGAAACAAAA
    DDX55 NM_020936.2 AGCGGAAGTG CTCGTTGGGG GTGCACAAGG CGCGTTCGAG 7
    CAGCGGCGAC CGACGCGGCG AAGGAGCGCG CCATGGAGCA
    TGTGACAGAG GGCTCCTGGG AGTCGCTGCC TGTGCCGCTG
    CACCCGCAGG TGCTGGGCGC GCTGCGGGAG CTGGGCTTCC
    CGTACATGAC GCCGGTGCAG TCCGCAACCA TCCCTCTGTT
    CATGCGAAAC AAAGATGTCG CTGCAGAAGC GGTCACAGGT
    AGTGGCAAAA CACTCGCTTT TGTCATCCCC ATCCTGGAAA
    TTCTTCTGAG AAGAGAAGAG AAGTTAAAAA AGAGTCAGGT
    TGGAGCCATA ATCATCACCC CCACTCGAGA GCTGGCCATT
    CAAATAGACG AGGTCCTGTC GCATTTCACG AAGCACTTCC
    CCGAGTTCAG CCAGATTCTT TGGATCGGAG GCAGGAATCC
    TGGAGAAGAT GTTGAGAGGT TTAAGCAACA AGGTGGGAAC
    ATCATTGTGG CCACTCCAGG CCGCTTGGAG GACATGTTCC
    GGAGGAAGGC CGAAGGCTTG GATCTGGCCA GCTGTGTGCG
    ATCCCTGGAT GTCCTGGTGT TGGATGAGGC AGACAGACTT
    CTGGACATGG GGTTTGAGGC AAGCATCAAC ACCATTCTGG
    AGTTTTTGCC AAAGCAGAGG AGAACAGGCC TTTTCTCTGC
    CACTCAGACG CAGGAAGTGG AGAACCTGGT GAGAGCGGGC
    CTCCGGAACC CTGTCCGGGT CTCAGTGAAG GAGAAGGGCG
    TGGCAGCCAG CAGTGCCCAG AAGACCCCCT CCCGCCTGGA
    AAACTACTAC ATGGTATGCA AGGCAGATGA GAAATTTAAT
    CAGCTGGTCC ATTTTCTTCG CAATCATAAG CAGGAGAAAC
    ACCTGGTCTT CTTCAGCACC TGTGCCTGTG TGGAATACTA
    TGGGAAGGCT CTGGAAGTGC TGGTGAAGGG CGTGAAGATT
    ATGTGCATTC ACGGAAAGAT GAAATATAAA CGCAATAAGA
    TCTTCATGGA GTTCCGCAAA TTGCAAAGTG GGATTTTAGT
    GTGCACTGAT GTGATGGCCC GGGGAATTGA TATTCCTGAA
    GTCAACTGGG TTTTGCAGTA TGACCCTCCC AGCAATGCAA
    GTGCCTTCGT GCATCGCTGC GGTCGCACAG CTCGCATTGG
    CCACGGGGGC AGCGCTCTGG TGTTCCTCCT GCCCATGGAA
    GAGTCATACA TCAATTTCCT TGCAATTAAC CAAAAATGCC
    CCCTGCAGGA GATGAAGCCC CAGAGAAACA CAGCGGACCT
    TCTGCCAAAA CTCAAGTCCA TGGCCCTGGC TGACAGAGCT
    GTGTTTGAAA AGGGCATGAA AGCTTTTGTG TCATATGTCC
    AAGCTTATGC AAAGCATGAA TGCAACCTGA TTTTCAGATT
    AAAGGATCTT GATTTTGCCA GCCTTGCTCG AGGTTTTGCC
    CTGCTGAGGA TGCCCAAGAT GCCAGAATTG AGAGGAAAGC
    AGTTTCCAGA TTTTGTGCCC GTGGACGTTA ATACCGACAC
    GATTCCATTT AAAGATAAAA TCAGAGAAAA GCAGAGGCAG
    AAACTCCTGG AGCAACAAAG AAGAGAGAAA ACAGAAAATG
    AAGGGAGAAG AAAATTCATA AAAAATAAAG CTTGGTCAAA
    GCAGAAGGCC AAAAAAGAAA AGAAGAAAAA AATGAATGAG
    AAAAGGAAAA GGGAAGAGGG TTCTGATATT GAAGATGAGG
    ACATGGAAGA ACTTCTTAAT GACACAAGAC TCTTGAAAAA
    ACTTAAGAAA GGCAAAATAA CTGAAGAAGA ATTTGAGAAG
    GGCTTGTTGA CAACTGGCAA AAGAACAATC AAGACAGTGG
    ATTTAGGGAT CTCAGATTTG GAAGATGACT GCTGATTCCA
    GTGCCACAGA TGAACCCACA AGGACATAGC TGTTCCCTAA
    CTTGGTGGAT GGCTCCAGTT TGCTTTTAAC GAAAATCACA
    ACTTCAGGAG ACATCTGAAA AGAATGATGT CTCTGAAAGC
    TGTCCTTTCA GATGAGGGAG AAATGAAGGA TTTCACACTT
    CAGAATATTT TACTAAAAAC ATTCCAGTCT TGGCCGGGTG
    CGGTGGCTCC TGCCTATAAT CCCAGCACTT TGGGAGGCTG
    AGGCAGGAGG ATCACTTGAG CCCAGGAGTT CAAGACCAGC
    CTGGGAACAC AGCGAGACCC TCTCATTAAA AACAACAAAA
    CAAAACAATT CCAGTCTTGG AGTAGTCTAA CAGAAGAAAA
    TGTAAAATTA TTTGAGTGTA AATAATAGAT GTCAGTATTT
    ATCATGATGG GTCACATATA GACATATGTA CATATTATAT
    ATATATATAT ATATATATAT ATATATATAT ATATATATAT
    ATAAGCTCTT TTTTCTGAGG CTATTTTATA GTTATTTTTA
    AACATAAAGA TACAGAAGTC TTCTTGACTT CTGATTTTCA
    AAACCATTCC TCAGTATCTT CAGGCATTTG ACCTCCTGAA
    TGTGCTTGGC CCTGGGCTTC AGTTATCCTT TGATGTCCTG
    CAGGGGTGGC TAATGTGCTG GGGTTTTTCT GTGTTAATAG
    TCACAGTATT GTTTTATTGG TGAATAGCTG AAAAACAGAG
    GGATTAAGTC ATATTCCGGG AAAGAGAATT ATAGTTTTTA
    TGCCTCCTGT TGAATAAATG GTGTCCTGAT TGCCTGGG
    DMD NM_000109.3 CGTTAAATGC AAACGCTGCT CTGGCTCATG TGTTTGCTCC 8
    GAGGTATAGG TTTTGTTCGA CTGACGTATC AGATAGTCAG
    AGTGGTTACC ACACCGACGT TGTAGCAGCT GCATAATAAA
    TGACTGAAAG AATCATGTTA GGCATGCCCA CCTAACCTAA
    CTTGAATCAT GCGAAAGGGG AGCTGTTGGA ATTCAAATAG
    ACTTTCTGGT TCCCAGCAGT CGGCAGTAAT AGAATGCTTT
    CAGGAAGATG ACAGAATCAG GAGAAAGATG CTGTTTTGCA
    CTATCTTGAT TTGTTACAGC AGCCAACTTA TTGGCATGAT
    GGAGTGACAG GAAAAACAGC TGGCATGGAA GATGAAAGAG
    AAGATGTTCA AAAGAAAACA TTCACAAAAT GGGTAAATGC
    ACAATTTTCT AAGTTTGGGA AGCAGCATAT TGAGAACCTC
    TTCAGTGACC TACAGGATGG GAGGCGCCTC CTAGACCTCC
    TCGAAGGCCT GACAGGGCAA AAACTGCCAA AAGAAAAAGG
    ATCCACAAGA GTTCATGCCC TGAACAATGT CAACAAGGCA
    CTGCGGGTTT TGCAGAACAA TAATGTTGAT TTAGTGAATA
    TTGGAAGTAC TGACATCGTA GATGGAAATC ATAAACTGAC
    TCTTGGTTTG ATTTGGAATA TAATCCTCCA CTGGCAGGTC
    AAAAATGTAA TGAAAAATAT CATGGCTGGA TTGCAACAAA
    CCAACAGTGA AAAGATTCTC CTGAGCTGGG TCCGACAATC
    AACTCGTAAT TATCCACAGG TTAATGTAAT CAACTTCACC
    ACCAGCTGGT CTGATGGCCT GGCTTTGAAT GCTCTCATCC
    ATAGTCATAG GCCAGACCTA TTTGACTGGA ATAGTGTGGT
    TTGCCAGCAG TCAGCCACAC AACGACTGGA ACATGCATTC
    AACATCGCCA GATATCAATT AGGCATAGAG AAACTACTCG
    ATCCTGAAGA TGTTGATACC ACCTATCCAG ATAAGAAGTC
    CATCTTAATG TACATCACAT CACTCTTCCA AGTTTTGCCT
    CAACAAGTGA GCATTGAAGC CATCCAGGAA GTGGAAATGT
    TGCCAAGGCC ACCTAAAGTG ACTAAAGAAG AACATTTTCA
    GTTACATCAT CAAATGCACT ATTCTCAACA GATCACGGTC
    AGTCTAGCAC AGGGATATGA GAGAACTTCT TCCCCTAAGC
    CTCGATTCAA GAGCTATGCC TACACACAGG CTGCTTATGT
    CACCACCTCT GACCCTACAC GGAGCCCATT TCCTTCACAG
    CATTTGGAAG CTCCTGAAGA CAAGTCATTT GGCAGTTCAT
    TGATGGAGAG TGAAGTAAAC CTGGACCGTT ATCAAACAGC
    TTTAGAAGAA GTATTATCGT GGCTTCTTTC TGCTGAGGAC
    ACATTGCAAG CACAAGGAGA GATTTCTAAT GATGTGGAAG
    TGGTGAAAGA CCAGTTTCAT ACTCATGAGG GGTACATGAT
    GGATTTGACA GCCCATCAGG GCCGGGTTGG TAATATTCTA
    CAATTGGGAA GTAAGCTGAT TGGAACAGGA AAATTATCAG
    AAGATGAAGA AACTGAAGTA CAAGAGCAGA TGAATCTCCT
    AAATTCAAGA TGGGAATGCC TCAGGGTAGC TAGCATGGAA
    AAACAAAGCA ATTTACATAG AGTTTTAATG GATCTCCAGA
    ATCAGAAACT GAAAGAGTTG AATGACTGGC TAACAAAAAC
    AGAAGAAAGA ACAAGGAAAA TGGAGGAAGA GCCTCTTGGA
    CCTGATCTTG AAGACCTAAA ACGCCAAGTA CAACAACATA
    AGGTGCTTCA AGAAGATCTA GAACAAGAAC AAGTCAGGGT
    CAATTCTCTC ACTCACATGG TGGTGGTAGT TGATGAATCT
    AGTGGAGATC ACGCAACTGC TGCTTTGGAA GAACAACTTA
    AGGTATTGGG AGATCGATGG GCAAACATCT GTAGATGGAC
    AGAAGACCGC TGGGTTCTTT TACAAGACAT CCTTCTCAAA
    TGGCAACGTC TTACTGAAGA ACAGTGCCTT TTTAGTGCAT
    GGCTTTCAGA AAAAGAAGAT GCAGTGAACA AGATTCACAC
    AACTGGCTTT AAAGATCAAA ATGAAATGTT ATCAAGTCTT
    CAAAAACTGG CCGTTTTAAA AGCGGATCTA GAAAAGAAAA
    AGCAATCCAT GGGCAAACTG TATTCACTCA AACAAGATCT
    TCTTTCAACA CTGAAGAATA AGTCAGTGAC CCAGAAGACG
    GAAGCATGGC TGGATAACTT TGCCCGGTGT TGGGATAATT
    TAGTCCAAAA ACTTGAAAAG AGTACAGCAC AGATTTCACA
    GGCTGTCACC ACCACTCAGC CATCACTAAC ACAGACAACT
    GTAATGGAAA CAGTAACTAC GGTGACCACA AGGGAACAGA
    TCCTGGTAAA GCATGCTCAA GAGGAACTTC CACCACCACC
    TCCCCAAAAG AAGAGGCAGA TTACTGTGGA TTCTGAAATT
    AGGAAAAGGT TGGATGTTGA TATAACTGAA CTTCACAGCT
    GGATTACTCG CTCAGAAGCT GTGTTGCAGA GTCCTGAATT
    TGCAATCTTT CGGAAGGAAG GCAACTTCTC AGACTTAAAA
    GAAAAAGTCA ATGCCATAGA GCGAGAAAAA GCTGAGAAGT
    TCAGAAAACT GCAAGATGCC AGCAGATCAG CTCAGGCCCT
    GGTGGAACAG ATGGTGAATG AGGGTGTTAA TGCAGATAGC
    ATCAAACAAG CCTCAGAACA ACTGAACAGC CGGTGGATCG
    AATTCTGCCA GTTGCTAAGT GAGAGACTTA ACTGGCTGGA
    GTATCAGAAC AACATCATCG CTTTCTATAA TCAGCTACAA
    CAATTGGAGC AGATGACAAC TACTGCTGAA AACTGGTTGA
    AAATCCAACC CACCACCCCA TCAGAGCCAA CAGCAATTAA
    AAGTCAGTTA AAAATTTGTA AGGATGAAGT CAACCGGCTA
    TCAGGTCTTC AACCTCAAAT TGAACGATTA AAAATTCAAA
    GCATAGCCCT GAAAGAGAAA GGACAAGGAC CCATGTTCCT
    GGATGCAGAC TTTGTGGCCT TTACAAATCA TTTTAAGCAA
    GTCTTTTCTG ATGTGCAGGC CAGAGAGAAA GAGCTACAGA
    CAATTTTTGA CACTTTGCCA CCAATGCGCT ATCAGGAGAC
    CATGAGTGCC ATCAGGACAT GGGTCCAGCA GTCAGAAACC
    AAACTCTCCA TACCTCAACT TAGTGTCACC GACTATGAAA
    TCATGGAGCA GAGACTCGGG GAATTGCAGG CTTTACAAAG
    TTCTCTGCAA GAGCAACAAA GTGGCCTATA CTATCTCAGC
    ACCACTGTGA AAGAGATGTC GAAGAAAGCG CCCTCTGAAA
    TTAGCCGGAA ATATCAATCA GAATTTGAAG AAATTGAGGG
    ACGCTGGAAG AAGCTCTCCT CCCAGCTGGT TGAGCATTGT
    CAAAAGCTAG AGGAGCAAAT GAATAAACTC CGAAAAATTC
    AGAATCACAT ACAAACCCTG AAGAAATGGA TGGCTGAAGT
    TGATGTTTTT CTGAAGGAGG AATGGCCTGC CCTTGGGGAT
    TCAGAAATTC TAAAAAAGCA GCTGAAACAG TGCAGACTTT
    TAGTCAGTGA TATTCAGACA ATTCAGCCCA GTCTAAACAG
    TGTCAATGAA GGTGGGCAGA AGATAAAGAA TGAAGCAGAG
    CCAGAGTTTG CTTCGAGACT TGAGACAGAA CTCAAAGAAC
    TTAACACTCA GTGGGATCAC ATGTGCCAAC AGGTCTATGC
    CAGAAAGGAG GCCTTGAAGG GAGGTTTGGA GAAAACTGTA
    AGCCTCCAGA AAGATCTATC AGAGATGCAC GAATGGATGA
    CACAAGCTGA AGAAGAGTAT CTTGAGAGAG ATTTTGAATA
    TAAAACTCCA GATGAATTAC AGAAAGCAGT TGAAGAGATG
    AAGAGAGCTA AAGAAGAGGC CCAACAAAAA GAAGCGAAAG
    TGAAACTCCT TACTGAGTCT GTAAATAGTG TCATAGCTCA
    AGCTCCACCT GTAGCACAAG AGGCCTTAAA AAAGGAACTT
    GAAACTCTAA CCACCAACTA CCAGTGGCTC TGCACTAGGC
    TGAATGGGAA ATGCAAGACT TTGGAAGAAG TTTGGGCATG
    TTGGCATGAG TTATTGTCAT ACTTGGAGAA AGCAAACAAG
    TGGCTAAATG AAGTAGAATT TAAACTTAAA ACCACTGAAA
    ACATTCCTGG CGGAGCTGAG GAAATCTCTG AGGTGCTAGA
    TTCACTTGAA AATTTGATGC GACATTCAGA GGATAACCCA
    AATCAGATTC GCATATTGGC ACAGACCCTA ACAGATGGCG
    GAGTCATGGA TGAGCTAATC AATGAGGAAC TTGAGACATT
    TAATTCTCGT TGGAGGGAAC TACATGAAGA GGCTGTAAGG
    AGGCAAAAGT TGCTTGAACA GAGCATCCAG TCTGCCCAGG
    AGACTGAAAA ATCCTTACAC TTAATCCAGG AGTCCCTCAC
    ATTCATTGAC AAGCAGTTGG CAGCTTATAT TGCAGACAAG
    GTGGACGCAG CTCAAATGCC TCAGGAAGCC CAGAAAATCC
    AATCTGATTT GACAAGTCAT GAGATCAGTT TAGAAGAAAT
    GAAGAAACAT AATCAGGGGA AGGAGGCTGC CCAAAGAGTC
    CTGTCTCAGA TTGATGTTGC ACAGAAAAAA TTACAAGATG
    TCTCCATGAA GTTTCGATTA TTCCAGAAAC CAGCCAATTT
    TGAGCAGCGT CTACAAGAAA GTAAGATGAT TTTAGATGAA
    GTGAAGATGC ACTTGCCTGC ATTGGAAACA AAGAGTGTGG
    AACAGGAAGT AGTACAGTCA CAGCTAAATC ATTGTGTGAA
    CTTGTATAAA AGTCTGAGTG AAGTGAAGTC TGAAGTGGAA
    ATGGTGATAA AGACTGGACG TCAGATTGTA CAGAAAAAGC
    AGACGGAAAA TCCCAAAGAA CTTGATGAAA GAGTAACAGC
    TTTGAAATTG CATTATAATG AGCTGGGAGC AAAGGTAACA
    GAAAGAAAGC AACAGTTGGA GAAATGCTTG AAATTGTCCC
    GTAAGATGCG AAAGGAAATG AATGTCTTGA CAGAATGGCT
    GGCAGCTACA GATATGGAAT TGACAAAGAG ATCAGCAGTT
    GAAGGAATGC CTAGTAATTT GGATTCTGAA GTTGCCTGGG
    GAAAGGCTAC TCAAAAAGAG ATTGAGAAAC AGAAGGTGCA
    CCTGAAGAGT ATCACAGAGG TAGGAGAGGC CTTGAAAACA
    GTTTTGGGCA AGAAGGAGAC GTTGGTGGAA GATAAACTCA
    GTCTTCTGAA TAGTAACTGG ATAGCTGTCA CCTCCCGAGC
    AGAAGAGTGG TTAAATCTTT TGTTGGAATA CCAGAAACAC
    ATGGAAACTT TTGACCAGAA TGTGGACCAC ATCACAAAGT
    GGATCATTCA GGCTGACACA CTTTTGGATG AATCAGAGAA
    AAAGAAACCC CAGCAAAAAG AAGACGTGCT TAAGCGTTTA
    AAGGCAGAAC TGAATGACAT ACGCCCAAAG GTGGACTCTA
    CACGTGACCA AGCAGCAAAC TTGATGGCAA ACCGCGGTGA
    CCACTGCAGG AAATTAGTAG AGCCCCAAAT CTCAGAGCTC
    AACCATCGAT TTGCAGCCAT TTCACACAGA ATTAAGACTG
    GAAAGGCCTC CATTCCTTTG AAGGAATTGG AGCAGTTTAA
    CTCAGATATA CAAAAATTGC TTGAACCACT GGAGGCTGAA
    ATTCAGCAGG GGGTGAATCT GAAAGAGGAA GACTTCAATA
    AAGATATGAA TGAAGACAAT GAGGGTACTG TAAAAGAATT
    GTTGCAAAGA GGAGACAACT TACAACAAAG AATCACAGAT
    GAGAGAAAGC GAGAGGAAAT AAAGATAAAA CAGCAGCTGT
    TACAGACAAA ACATAATGCT CTCAAGGATT TGAGGTCTCA
    AAGAAGAAAA AAGGCTCTAG AAATTTCTCA TCAGTGGTAT
    CAGTACAAGA GGCAGGCTGA TGATCTCCTG AAATGCTTGG
    ATGACATTGA AAAAAAATTA GCCAGCCTAC CTGAGCCCAG
    AGATGAAAGG AAAATAAAGG AAATTGATCG GGAATTGCAG
    AAGAAGAAAG AGGAGCTGAA TGCAGTGCGT AGGCAAGCTG
    AGGGCTTGTC TGAGGATGGG GCCGCAATGG CAGTGGAGCC
    AACTCAGATC CAGCTCAGCA AGCGCTGGCG GGAAATTGAG
    AGCAAATTTG CTCAGTTTCG AAGACTCAAC TTTGCACAAA
    TTCACACTGT CCGTGAAGAA ACGATGATGG TGATGACTGA
    AGACATGCCT TTGGAAATTT CTTATGTGCC TTCTACTTAT
    TTGACTGAAA TCACTCATGT CTCACAAGCC CTATTAGAAG
    TGGAACAACT TCTCAATGCT CCTGACCTCT GTGCTAAGGA
    CTTTGAAGAT CTCTTTAAGC AAGAGGAGTC TCTGAAGAAT
    ATAAAAGATA GTCTACAACA AAGCTCAGGT CGGATTGACA
    TTATTCATAG CAAGAAGACA GCAGCATTGC AAAGTGCAAC
    GCCTGTGGAA AGGGTGAAGC TACAGGAAGC TCTCTCCCAG
    CTTGATTTCC AATGGGAAAA AGTTAACAAA ATGTACAAGG
    ACCGACAAGG GCGATTTGAC AGATCTGTTG AGAAATGGCG
    GCGTTTTCAT TATGATATAA AGATATTTAA TCAGTGGCTA
    ACAGAAGCTG AACAGTTTCT CAGAAAGACA CAAATTCCTG
    AGAATTGGGA ACATGCTAAA TACAAATGGT ATCTTAAGGA
    ACTCCAGGAT GGCATTGGGC AGCGGCAAAC TGTTGTCAGA
    ACATTGAATG CAACTGGGGA AGAAATAATT CAGCAATCCT
    CAAAAACAGA TGCCAGTATT CTACAGGAAA AATTGGGAAG
    CCTGAATCTG CGGTGGCAGG AGGTCTGCAA ACAGCTGTCA
    GACAGAAAAA AGAGGCTAGA AGAACAAAAG AATATCTTGT
    CAGAATTTCA AAGAGATTTA AATGAATTTG TTTTATGGTT
    GGAGGAAGCA GATAACATTG CTAGTATCCC ACTTGAACCT
    GGAAAAGAGC AGCAACTAAA AGAAAAGCTT GAGCAAGTCA
    AGTTACTGGT GGAAGAGTTG CCCCTGCGCC AGGGAATTCT
    CAAACAATTA AATGAAACTG GAGGACCCGT GCTTGTAAGT
    GCTCCCATAA GCCCAGAAGA GCAAGATAAA CTTGAAAATA
    AGCTCAAGCA GACAAATCTC CAGTGGATAA AGGTTTCCAG
    AGCTTTACCT GAGAAACAAG GAGAAATTGA AGCTCAAATA
    AAAGACCTTG GGCAGCTTGA AAAAAAGCTT GAAGACCTTG
    AAGAGCAGTT AAATCATCTG CTGCTGTGGT TATCTCCTAT
    TAGGAATCAG TTGGAAATTT ATAACCAACC AAACCAAGAA
    GGACCATTTG ACGTTCAGGA AACTGAAATA GCAGTTCAAG
    CTAAACAACC GGATGTGGAA GAGATTTTGT CTAAAGGGCA
    GCATTTGTAC AAGGAAAAAC CAGCCACTCA GCCAGTGAAG
    AGGAAGTTAG AAGATCTGAG CTCTGAGTGG AAGGCGGTAA
    ACCGTTTACT TCAAGAGCTG AGGGCAAAGC AGCCTGACCT
    AGCTCCTGGA CTGACCACTA TTGGAGCCTC TCCTACTCAG
    ACTGTTACTC TGGTGACACA ACCTGTGGTT ACTAAGGAAA
    CTGCCATCTC CAAACTAGAA ATGCCATCTT CCTTGATGTT
    GGAGGTACCT GCTCTGGCAG ATTTCAACCG GGCTTGGACA
    GAACTTACCG ACTGGCTTTC TCTGCTTGAT CAAGTTATAA
    AATCACAGAG GGTGATGGTG GGTGACCTTG AGGATATCAA
    CGAGATGATC ATCAAGCAGA AGGCAACAAT GCAGGATTTG
    GAACAGAGGC GTCCCCAGTT GGAAGAACTC ATTACCGCTG
    CCCAAAATTT GAAAAACAAG ACCAGCAATC AAGAGGCTAG
    AACAATCATT ACGGATCGAA TTGAAAGAAT TCAGAATCAG
    TGGGATGAAG TACAAGAACA CCTTCAGAAC CGGAGGCAAC
    AGTTGAATGA AATGTTAAAG GATTCAACAC AATGGCTGGA
    AGCTAAGGAA GAAGCTGAGC AGGTCTTAGG ACAGGCCAGA
    GCCAAGCTTG AGTCATGGAA GGAGGGTCCC TATACAGTAG
    ATGCAATCCA AAAGAAAATC ACAGAAACCA AGCAGTTGGC
    CAAAGACCTC CGCCAGTGGC AGACAAATGT AGATGTGGCA
    AATGACTTGG CCCTGAAACT TCTCCGGGAT TATTCTGCAG
    ATGATACCAG AAAAGTCCAC ATGATAACAG AGAATATCAA
    TGCCTCTTGG AGAAGCATTC ATAAAAGGGT GAGTGAGCGA
    GAGGCTGCTT TGGAAGAAAC TCATAGATTA CTGCAACAGT
    TCCCCCTGGA CCTGGAAAAG TTTCTTGCCT GGCTTACAGA
    AGCTGAAACA ACTGCCAATG TCCTACAGGA TGCTACCCGT
    AAGGAAAGGC TCCTAGAAGA CTCCAAGGGA GTAAAAGAGC
    TGATGAAACA ATGGCAAGAC CTCCAAGGTG AAATTGAAGC
    TCACACAGAT GTTTATCACA ACCTGGATGA AAACAGCCAA
    AAAATCCTGA GATCCCTGGA AGGTTCCGAT GATGCAGTCC
    TGTTACAAAG ACGTTTGGAT AACATGAACT TCAAGTGGAG
    TGAACTTCGG AAAAAGTCTC TCAACATTAG GTCCCATTTG
    GAAGCCAGTT CTGACCAGTG GAAGCGTCTG CACCTTTCTC
    TGCAGGAACT TCTGGTGTGG CTACAGCTGA AAGATGATGA
    ATTAAGCCGG CAGGCACCTA TTGGAGGCGA CTTTCCAGCA
    GTTCAGAAGC AGAACGATGT ACATAGGGCC TTCAAGAGGG
    AATTGAAAAC TAAAGAACCT GTAATCATGA GTACTCTTGA
    GACTGTACGA ATATTTCTGA CAGAGCAGCC TTTGGAAGGA
    CTAGAGAAAC TCTACCAGGA GCCCAGAGAG CTGCCTCCTG
    AGGAGAGAGC CCAGAATGTC ACTCGGCTTC TACGAAAGCA
    GGCTGAGGAG GTCAATACTG AGTGGGAAAA ATTGAACCTG
    CACTCCGCTG ACTGGCAGAG AAAAATAGAT GAGACCCTTG
    AAAGACTCCA GGAACTTCAA GAGGCCACGG ATGAGCTGGA
    CCTCAAGCTG CGCCAAGCTG AGGTGATCAA GGGATCCTGG
    CAGCCCGTGG GCGATCTCCT CATTGACTCT CTCCAAGATC
    ACCTCGAGAA AGTCAAGGCA CTTCGAGGAG AAATTGCGCC
    TCTGAAAGAG AACGTGAGCC ACGTCAATGA CCTTGCTCGC
    CAGCTTACCA CTTTGGGCAT TCAGCTCTCA CCGTATAACC
    TCAGCACTCT GGAAGACCTG AACACCAGAT GGAAGCTTCT
    GCAGGTGGCC GTCGAGGACC GAGTCAGGCA GCTGCATGAA
    GCCCACAGGG ACTTTGGTCC AGCATCTCAG CACTTTCTTT
    CCACGTCTGT CCAGGGTCCC TGGGAGAGAG CCATCTCGCC
    AAACAAAGTG CCCTACTATA TCAACCACGA GACTCAAACA
    ACTTGCTGGG ACCATCCCAA AATGACAGAG CTCTACCAGT
    CTTTAGCTGA CCTGAATAAT GTCAGATTCT CAGCTTATAG
    GACTGCCATG AAACTCCGAA GACTGCAGAA GGCCCTTTGC
    TTGGATCTCT TGAGCCTGTC AGCTGCATGT GATGCCTTGG
    ACCAGCACAA CCTCAAGCAA AATGACCAGC CCATGGATAT
    CCTGCAGATT ATTAATTGTT TGACCACTAT TTATGACCGC
    CTGGAGCAAG AGCACAACAA TTTGGTCAAC GTCCCTCTCT
    GCGTGGATAT GTGTCTGAAC TGGCTGCTGA ATGTTTATGA
    TACGGGACGA ACAGGGAGGA TCCGTGTCCT GTCTTTTAAA
    ACTGGCATCA TTTCCCTGTG TAAAGCACAT TTGGAAGACA
    AGTACAGATA CCTTTTCAAG CAAGTGGCAA GTTCAACAGG
    ATTTTGTGAC CAGCGCAGGC TGGGCCTCCT TCTGCATGAT
    TCTATCCAAA TTCCAAGACA GTTGGGTGAA GTTGCATCCT
    TTGGGGGCAG TAACATTGAG CCAAGTGTCC GGAGCTGCTT
    CCAATTTGCT AATAATAAGC CAGAGATCGA AGCGGCCCTC
    TTCCTAGACT GGATGAGACT GGAACCCCAG TCCATGGTGT
    GGCTGCCCGT CCTGCACAGA GTGGCTGCTG CAGAAACTGC
    CAAGCATCAG GCCAAATGTA ACATCTGCAA AGAGTGTCCA
    ATCATTGGAT TCAGGTACAG GAGTCTAAAG CACTTTAATT
    ATGACATCTG CCAAAGCTGC TTTTTTTCTG GTCGAGTTGC
    AAAAGGCCAT AAAATGCACT ATCCCATGGT GGAATATTGC
    ACTCCGACTA CATCAGGAGA AGATGTTCGA GACTTTGCCA
    AGGTACTAAA AAACAAATTT CGAACCAAAA GGTATTTTGC
    GAAGCATCCC CGAATGGGCT ACCTGCCAGT GCAGACTGTC
    TTAGAGGGGG ACAACATGGA AACTCCCGTT ACTCTGATCA
    ACTTCTGGCC AGTAGATTCT GCGCCTGCCT CGTCCCCTCA
    GCTTTCACAC GATGATACTC ATTCACGCAT TGAACATTAT
    GCTAGCAGGC TAGCAGAAAT GGAAAACAGC AATGGATCTT
    ATCTAAATGA TAGCATCTCT CCTAATGAGA GCATAGATGA
    TGAACATTTG TTAATCCAGC ATTACTGCCA AAGTTTGAAC
    CAGGACTCCC CCCTGAGCCA GCCTCGTAGT CCTGCCCAGA
    TCTTGATTTC CTTAGAGAGT GAGGAAAGAG GGGAGCTAGA
    GAGAATCCTA GCAGATCTTG AGGAAGAAAA CAGGAATCTG
    CAAGCAGAAT ATGACCGTCT AAAGCAGCAG CACGAACATA
    AAGGCCTGTC CCCACTGCCG TCCCCTCCTG AAATGATGCC
    CACCTCTCCC CAGAGTCCCC GGGATGCTGA GCTCATTGCT
    GAGGCCAAGC TACTGCGTCA ACACAAAGGC CGCCTGGAAG
    CCAGGATGCA AATCCTGGAA GACCACAATA AACAGCTGGA
    GTCACAGTTA CACAGGCTAA GGCAGCTGCT GGAGCAACCC
    CAGGCAGAGG CCAAAGTGAA TGGCACAACG GTGTCCTCTC
    CTTCTACCTC TCTACAGAGG TCCGACAGCA GTCAGCCTAT
    GCTGCTCCGA GTGGTTGGCA GTCAAACTTC GGACTCCATG
    GGTGAGGAAG ATCTTCTCAG TCCTCCCCAG GACACAAGCA
    CAGGGTTAGA GGAGGTGATG GAGCAACTCA ACAACTCCTT
    CCCTAGTTCA AGAGGAAGAA ATACCCCTGG AAAGCCAATG
    AGAGAGGACA CAATGTAGGA AGTCTTTTCC ACATGGCAGA
    TGATTTGGGC AGAGCGATGG AGTCCTTAGT ATCAGTCATG
    ACAGATGAAG AAGGAGCAGA ATAAATGTTT TACAACTCCT
    GATTCCCGCA TGGTTTTTAT AATATTCATA CAACAAAGAG
    GATTAGACAG TAAGAGTTTA CAAGAAATAA ATCTATATTT
    TTGTGAAGGG TAGTGGTATT ATACTGTAGA TTTCAGTAGT
    TTCTAAGTCT GTTATTGTTT TGTTAACAAT GGCAGGTTTT
    ACACGTCTAT GCAATTGTAC AAAAAAGTTA TAAGAAAACT
    ACATGTAAAA TCTTGATAGC TAAATAACTT GCCATTTCTT
    TATATGGAAC GCATTTTGGG TTGTTTAAAA ATTTATAACA
    GTTATAAAGA AAGATTGTAA ACTAAAGTGT GCTTTATAAA
    AAAAAGTTGT TTATAAAAAC CCCTAAAAAC AAAACAAACA
    CACACACACA CACATACACA CACACACACA AAACTTTGAG
    GCAGCGCATT GTTTTGCATC CTTTTGGCGT GATATCCATA
    TGAAATTCAT GGCTTTTTCT TTTTTTGCAT ATTAAAGATA
    AGACTTCCTC TACCACCACA CCAAATGACT ACTACACACT
    GCTCATTTGA GAACTGTCAG CTGAGTGGGG CAGGCTTGAG
    TTTTCATTTC ATATATCTAT ATGTCTATAA GTATATAAAT
    ACTATAGTTA TATAGATAAA GAGATACGAA TTTCTATAGA
    CTGACTTTTT CCATTTTTTA AATGTTCATG TCACATCCTA
    ATAGAAAGAA ATTACTTCTA GTCAGTCATC CAGGCTTACC
    TGCTTGGTCT AGAATGGATT TTTCCCGGAG CCGGAAGCCA
    GGAGGAAACT ACACCACACT AAAACATTGT CTACAGCTCC
    AGATGTTTCT CATTTTAAAC AACTTTCCAC TGACAACGAA
    AGTAAAGTAA AGTATTGGAT TTTTTTAAAG GGAACATGTG
    AATGAATACA CAGGACTTAT TATATCAGAG TGAGTAATCG
    GTTGGTTGGT TGATTGATTG ATTGATTGAT ACATTCAGCT
    TCCTGCTGCT AGCAATGCCA CGATTTAGAT TTAATGATGC
    TTCAGTGGAA ATCAATCAGA AGGTATTCTG ACCTTGTGAA
    CATCAGAAGG TATTTTTTAA CTCCCAAGCA GTAGCAGGAC
    GATGATAGGG CTGGAGGGCT ATGGATTCCC AGCCCATCCC
    TGTGAAGGAG TAGGCCACTC TTTAAGTGAA GGATTGGATG
    ATTGTTCATA ATACATAAAG TTCTCTGTAA TTACAACTAA
    ATTATTATGC CCTCTTCTCA CAGTCAAAAG GAACTGGGTG
    GTTTGGTTTT TGTTGCTTTT TTAGATTTAT TGTCCCATGT
    GGGATGAGTT TTTAAATGCC ACAAGACATA ATTTAAAATA
    AATAAACTTT GGGAAAAGGT GTAAAACAGT AGCCCCATCA
    CATTTGTGAT ACTGACAGGT ATCAACCCAG AAGCCCATGA
    ACTGTGTTTC CATCCTTTGC ATTTCTCTGC GAGTAGTTCC
    ACACAGGTTT GTAAGTAAGT AAGAAAGAAG GCAAATTGAT
    TCAAATGTTA CAAAAAAACC CTTCTTGGTG GATTAGACAG
    GTTAAATATA TAAACAAACA AACAAAAATT GCTCAAAAAA
    GAGGAGAAAA GCTCAAGAGG AAAAGCTAAG GACTGGTAGG
    AAAAAGCTTT ACTCTTTCAT GCCATTTTAT TTCTTTTTGA
    TTTTTAAATC ATTCATTCAA TAGATACCAC CGTGTGACCT
    ATAATTTTGC AAATCTGTTA CCTCTGACAT CAAGTGTAAT
    TAGCTTTTGG AGAGTGGGCT GACATCAAGT GTAATTAGCT
    TTTGGAGAGT GGGTTTTGTC CATTATTAAT AATTAATTAA
    TTAACATCAA ACACGGCTTC TCATGCTATT TCTACCTCAC
    TTTGGTTTTG GGGTGTTCCT GATAATTGTG CACACCTGAG
    TTCACAGCTT CACCACTTGT CCATTGCGTT ATTTTCTTTT
    TCCTTTATAA TTCTTTCTTT TTCCTTCATA ATTTTCAAAA
    GAAAACCCAA AGCTCTAAGG TAACAAATTA CCAAATTACA
    TGAAGATTTG GTTTTTGTCT TGCATTTTTT TCCTTTATGT
    GACGCTGGAC CTTTTCTTTA CCCAAGGATT TTTAAAACTC
    AGATTTAAAA CAAGGGGTTA CTTTACATCC TACTAAGAAG
    TTTAAGTAAG TAAGTTTCAT TCTAAAATCA GAGGTAAATA
    GAGTGCATAA ATAATTTTGT TTTAATCTTT TTGTTTTTCT
    TTTAGACACA TTAGCTCTGG AGTGAGTCTG TCATAATATT
    TGAACAAAAA TTGAGAGCTT TATTGCTGCA TTTTAAGCAT
    AATTAATTTG GACATTATTT CGTGTTGTGT TCTTTATAAC
    CACCAAGTAT TAAACTGTAA ATCATAATGT AACTGAAGCA
    TAAACATCAC ATGGCATGTT TTGTCATTGT TTTCAGGTAC
    TGAGTTCTTA CTTGAGTATC ATAATATATT GTGTTTTAAC
    ACCAACACTG TAACATTTAC GAATTATTTT TTTAAACTTC
    AGTTTTACTG CATTTTCACA ACATATCAGA CTTCACCAAA
    TATATGCCTT ACTATTGTAT TATAGTACTG CTTTACTGTG
    TATCTCAATA AAGCACGCAG TTATGTTAC
    DNAJC9 NM_015190.4 GGATGCGCGG CGTGGCCACG CCCCTTCAGT GCTTGTGACG 9
    CAGGCGCCCT GGGCTTTTTG GGCGCGAAAA AGAAGCAGTC
    CTGGGTTGTA CCCGGCGCAG CTGGGAGCGG CTGCTTCCTC
    CGGGGTCGTA TCTCCGCCCG GCATGGGGCT GCTGGACCTT
    TGCGAGGAAG TGTTCGGCAC CGCCGACCTT TACCGGGTGC
    TGGGCGTGCG ACGCGAGGCC TCCGACGGCG AGGTCCGACG
    AGGCTACCAC AAGGTGTCCC TGCAGGTACA CCCGGACCGG
    GTGGGTGAGG GCGACAAGGA GGACGCCACC CGCCGCTTCC
    AGATCCTGGG AAAAGTCTAT TCCGTTCTCA GTGACAGAGA
    ACAGAGAGCA GTGTACGATG AGCAGGGAAC AGTGGACGAG
    GACTCTCCTG TGCTCACCCA AGACCGAGAC TGGGAGGCGT
    ATTGGCGGCT ACTCTTTAAA AAGATATCTT TAGAGGACAT
    TCAAGCTTTT GAAAAGACAT ACAAAGGTTC GGAAGAAGAG
    CTGGCTGATA TTAAGCAGGC CTATCTGGAC TTCAAGGGTG
    ACATGGATCA GATCATGGAG TCTGTGCTTT GCGTGCAGTA
    CACAGAGGAA CCCAGGATAA GGAATATCAT TCAGCAAGCT
    ATTGACGCCG GAGAGGTCCC ATCCTATAAT GCCTTTGTCA
    AAGAATCGAA ACAAAAGATG AATGCAAGGA AAAGGAGGGC
    TCAGGAAGAG GCCAAAGAAG CAGAAATGAG CAGAAAGGAG
    TTGGGGCTTG ATGAAGGCGT GGATAGCCTG AAGGCAGCCA
    TTCAGAGCAG ACAAAAGGAT CGGCAAAAGG AAATGGACAA
    TTTTCTGGCT CAGATGGAAG CAAAGTACTG CAAATCTTCC
    AAAGGAGGAG GGAAAAAATC TGCTCTCAAG AAAGAAAAGA
    AATAATGGAA TTTTTCTCTT CAAAGGTCCT TAGGTGTAAA
    TTGATGCCAT CGTAGGCAAG GTGCAGGCAG GATTTGAAGG
    CAAAAGTCAA TTCAGCTCTT GAGAAAAGGT GTCTTTCCAG
    CCTGAATTTT TCAGATTGAC TAGACCAAGC AGAATCTCTC
    AACCTGATCT TAGTATTTCC TAGAAAGCAC TTGACATTGT
    GTGAGGTCTC ACCTGAAGGA ACTTGGTGGT GACATTTGGG
    AGGGTGGAGG GAGGCAGTGT CCTTCCTGAC AGCACTTGCC
    TCCATGGATC TTCTGTACAC AGAACTCTTA TCTAGGATGT
    GGTTCTGTTC ATGCTGCTTT CTGCGATGTG CGTGTCTGTT
    AGAATAGGCT CTCTACCCAG CTAGAACACC TTCCAGACAC
    TTGCTGGACA GCTATCTTCC ACATACTTCC CAGTTTACAT
    TTGGTCTTAA TGATCTTGAA TAGATCCTCT CTTCATTTTA
    CTCAGCCAGG TTTTGTACTG ATGTACAGGT GTTAAATTAC
    TTCAAGCATT TTTGTAAGAG GTGTATATAA TTCAATAAAA
    AAGGTAAAAC ATGATGATTA AGTTCTGGGG GCTTTGTAAA
    TGATCCCACT AAAATGTGAC CTAGGAAAAA TATGAATGGT
    GTTTAGGATG AGAGAAAAGG GGAAAACAAT AGCCCTGGTC
    AGCTTTATAA TAGAGAGCCT GGTTTCCCTA GCATGAAGAG
    ATGTATGTTG TAGTCCTGCC ACTGATTACT GAAGTCCTGC
    CATTAATTGC TGAATGTCTT CAGTTGGGCC ACTGAGCTTG
    TCTGAATCTG TTCCCTTTTA TAAAAGAGTT ACTACATCAA
    AACAAAGAGT GAAATCCAAA TTTGTCAAAC TGTATGTATT
    AAACATGTCC AGTTTTTTGG TTAAAAAAAA ATTGCACTGG
    CTTTGAGGGA AAACACACAG GGTGAGGGAA TTGGGCTAAA
    TGACTTCTTA CAGGCCCCTT TCTGATTCTT TAACTTTGAA
    AGGCAAGCCA TATTGATCCA GTTGTTATAG TGAACTCATG
    GTAATGGTTT GTGAGAACAA TAGAGATTTT CATTTCTATG
    TAGATGAGTT GGTATGAGAA TATATGGAAT TTTTAAGGGA
    CTGTTTAAAT CTTTGATTTG TAGACTATTA AATATACCGT
    ATGCATAAAG TAAGCCTTTA GCTCTAAGGT AAAGACGACA
    CGTTTTCGGT TTGTGACTAC AAATAGGTTA AAAATAGATT
    TTAATTTTAT TAAAAATATA ATTTAATGCA GGTTGTTTGA
    AGCATCTGTC TTCATATGAT GGCATTAGAA CACCTTGGTA
    TAATAAAAAG TTACCGTAAT TTATGATTAT TTGAATTTAT
    CCATTCTGAA AATTAATAAG ATCTAAAACT GGCATGACAA
    TCAAGATTTG TATTTAGTGA AATTTAAAAT AAATGTAAGC
    CATAGTTAAA AAAAAAAAAA AAAAA
    ENOSF1 NM_001126123.3 CGCCCTCCCG CCGCGCGCTC GGGATCCCGA CCAGTCCTGA 10
    CCGCACGGGG GCCGCGGCCA CGGGGCGCAG GGGCCATGGT
    GCGCGGCAGG ATCTCCCGGC TCTCGGTCCG GGACGTGCGC
    TTCCCCACGT CGCTTGGGGG CCACGGCGCG GACGCCATGC
    ACACGGACCC TGACTACTCG GCTGCCTATG TCGTCATAGA
    AACTGATGCA GAAGATGGAA TCAAGGGGTG TGGAATTACC
    TTCACTCTGG GAAAAGGCAC TGAAGTTGAT TGGTCCAGAA
    AAGGGCGTGG TGCACCTGGC GACAGCGGCC GTCCTAAACG
    CGGTGTGGGA CTTGTGGGCC AAGCAGGAGG GAAAGCCTGT
    CTGGAAGTTA CTTGTGGACA TGGATCCCAG GATGCTGGTA
    TCCTGCATAG ATTTCAGGTA CATCACTGAT GTCCTGACTG
    AGGAGGATGC CCTAGAAATA CTGCAGAAAG GTCAAATTGG
    TAAAAAAGAA AGAGAGAAGC AAATGCTGGC ACAAGGATAC
    CCTGCTTACA CGACATCGTG CGCCTGGCTG GGGTACTCAG
    ATGACACGTT GAAGCAGCTC TGTGCCCAGG CGCTGAAGGA
    TGGCTGGACC AGGTTTAAAG TAAAGGTGGG TGCTGATCTC
    CAGGATGACA TGCGAAGATG CCAAATCATC CGAGACATGA
    TTGGACCGGA AAAGACTTTG ATGATGGATG CCAACCAGCG
    CTGGGATGTG CCTGAGGCGG TGGAGTGGAT GTCCAAGCTG
    GCCAAGTTCA AGCCATTGTG GATTGAGGAG CCAACCTCCC
    CTGATGACAT TCTGGGGCAC GCCACCATTT CCAAGGCACT
    GGTCCCATTA GGAATTGGCA TTGCCACAGG AGAACAGTGC
    CACAATAGAG TGATATTTAA GCAACTCCTA CAGGCGAAGG
    CCCTGCAGTT CCTCCAGATT GACAGTTGCA GACTGGGCAG
    TGTCAATGAG AACCTCTCAG TATTGCTGAT GGCCAAAAAG
    TTTGAAATTC CTGTTTGCCC CCATGCTGGT GGAGTTGGCC
    TCTGTGAACT GGTGCAGCAC CTGATTATAT TTGACTACAT
    ATCAGTTTCT GCAAGCCTTG AAAATAGGGT GTGTGAGTAT
    GTTGACCACC TGCATGAGCA TTTCAAGTAT CCCGTGATGA
    TCCAGCGGGC TTCCTACATG CCTCCCAAGG ATCCCGGCTA
    CTCAACAGAA ATGAAGGAGG AATCTGTAAA GAAACACCAG
    TATCCAGATG GTGAAGTTTG GAAGAAACTC CTTCCTGCTC
    AAGAAAATTA AGTGCTCAGC CCCAACAACT TTTTTCTTTC
    TGAAGTGAAA GGGCTTAAAA TTTCTTGGAA ATAGTTTTAC
    AAAAATGGAT TTAAAAAATC CTACCGATCA AGATGAGTTC
    AGCTAGAAGT CATACCACCC TCAGGAATCA GCTAAAGCAA
    AAAGAACTTT TACCTCGGCA TCCAGCCCAA CCCCTAAAGA
    CTGACAATAT CCTTCGAGCT CCTTTGAAAG CACCCTAAAC
    AGCCATTTCC ATTTTAATAG TTGGATGCGG ATTGTACCCT
    TCAATCTGAA AGTCTTCAGC TTTGAAGTCA TCAATTTTCT
    CAACTTTTCG AAGAATCCTG AGCTTTGGGA AAGGTCTGGG
    TTCTCGCTGA AGCTAAAAAC AAAATAAGGC CATTATTTTG
    CCATAATTGT ACGACCTGTT GTAATTGCTC CTCATGTCCG
    TGAAACAAGT ACACAGGATG TGATCAACAA AGTTCTATTT
    TACAGGAGTA TGATCCTGTC GATACCTTGC CGTAGGTTAT
    GTAACATGAT TGGAGCGCAA CCAGCTGTTC TCTTGCACAG
    ATCGAGAGTG AGGGGTATTT TGTGACATTA CACAGCATCA
    GGAGCCTGGT GCCTCATCAG GTGTAAGTTC TTATAACCAC
    TCTTGGCAAA TTTATTAAAG ACAGGAACAC AGTCAATCTG
    TAACTCATAG TAGCTCTACG TTTACTTGAA TTCCACAATC
    CCTAACCCAT CTGTCCCTGG CAGAAAGAAG GAAAGATGAC
    ATGCATGGAC AGTGAACAGA AAGGGATGAA AGCCAGGATT
    CCTGGGATGA ACAGACAGTG GCAATTAGGA TGTGAAGACA
    GGTCACAACC TATTACTATG TCTAAAAACG ACCAGAGCAG
    AGAGCCAGAG AGAATAAGCC TGAAGTCACC TCCACTCAAA
    AGCAGCCAAA CTCCCTCAAA GGAGTAACTT TTAAAACCTG
    GATCTAACCT GGAAGGGGCT AAAAAGTGTC TGGTTCTGAG
    TTTTTTTCCT TAAGGCTCAT GAAGCAGATG AACTTACATT
    TTTATTGCCA TTTCATATCA ATTGTTGGCT GCTATAACTT
    AGGGATTTCA ACAGACTTTT GAAGTTTGGA CCTAAATATT
    GTACTTAATG TAAAATTAAC AAAAAATATT TATGGCCAGG
    GTGGTGGCTT ATGCCTGTAA TTCCAGAATT TTCGGAGGCT
    GAGGCAGGTG GATCACTTGA AGTCAGGAGT TTGAGACTAG
    CCTGGCCAAC ATGATGAAAC CCCATCTCTA CTAATAATAC
    AAAAATTAGC TGGGTGTGGT GGCATGTGCC TGTAATCCCA
    GCTACCTGGG AGGCTGAGGC AGAAGAATTG CTTGAACCCG
    GGAGGTGGAG GTTGCAGTGA GCTGAGATCG CACCACGGCA
    CACTCCAGCC TGGCCGACAG AGAAAGACTC CATCTCAAAA
    AAAAAAGAAA AGGAAAAACA TTTGCACTTC AATTCTCCTT
    CAAGTTAAAA TGAGTTAAAA TGCCCCCTTT TGGACAATCC
    CCTGGCTTGA ATGTGGCTCT TCCCTCTCTG GTACTGGTGC
    TTAGTACCTC ACAGCACCTG ACATGTTAAG TGCCCATGGT
    TGCTGAGGCA GATGCCTGCC TTGTCCTGCC CACCTGCCCA
    CCACTTCTCC CTAAACTGAA GCCCCACATT TGGAGCAGTC
    ATCTTTATCT TGGACACAGC ATTGAGCAGA TGCCTGTTCC
    ACAGTCAACC TTTTATCAAG AGAAGGTACC AAACCCAAAA
    GTATAACATC TAATTCTTAC CTGAATTTTC AGTGGCTCGA
    TGTGATTCAG GTAAATATGT GCATCTCCCA AAGTGTGTAT
    AAAGTCACCT GGCTATAAAC CCGGGGGAGA AAGCAGAACA
    GTATGTTAGT TTCAATTCTT TAAAACATCA TTTAAAAACA
    TTAGAATATG CAGACACCGC AAGGCTTTTT TTAAAAAAAT
    AATTTAGTGT AGCTTTTCCA TTTTTTTGTA GCAACAGCAT
    CTTGTTATGT TGCCCAGGCT GGTATTGAAC TCCAGACCTC
    AAGCAATTGC TCCTGTCTCA GTCTCCCAAA GTGCTGGGAT
    TACAGGCATG AGCCACCATA CCCAACCTCA GCATAGCTTT
    TGAGAAAATC CATAGAAGCT GTATCACAAA CAACCTGTAT
    AGATCTGTTA GTGCGTATAC CACAGGGCCA GAAAACCTTC
    CAGAAGAGGA AGGTTTCAAA GTAAAAGCTG GTTCATTTCT
    TACTTACACA TATCAAATTT AAAAGCTAAT CAGAGACTAA
    ACTCTGCAAT TTGTTTTCCC ATATTAAAGA ACTGAAGAGC
    TCAGTGTGGT AGGCTGGCAA GTCACCCTTC CCGAGACAGC
    CCACCTTCAG GCCCGTGATG TGCGCAATCA TGTACGTGAG
    CAGGGCGTAG CTGGCGATGT TGAAAGGCAC ACCGAGGCCC
    ATGTCTCCCG ATCTCTGGTA CAGCTGGCAG GACAGCTCAC
    TGTTCACCAC ATAGAACTGG CAGAGGGCAT GGCATGGAGG
    CAGCGCCATC AGAGGAAGAT CTGAGGAACC AGCAGAGGAA
    GATAAGGAGG GATGGTGGTT TGAAAGACCA CAGCTAAAGG
    CAAAGTAAAA CAGGAGAGAA ACAGAAGCCA ACTCATATGG
    TGGAGACCAG GAGAGAGAGC CACTGGGCTG CAGTGATGTC
    CATAACAGCC TCTGCAGCGA TGGCACGGAG CTGAGGGAGA
    CTATCCATCG GTGCAAGGTT TCTGCAGGTG TCCATTTACG
    GCTGAAGCAA TGCTCTTCCA TCAGAGCTGA AGGGATCTGG
    GCTACCTCGT GGCACCAGAT TACAAATACA GCAGGAATAA
    TTCTGTTTGC CACAGGAAAC TGGTGCTTCT GGTACACCCT
    CCTATATTAA AAGTCTCTAT TACATGGCAA AAAAAAAAAA
    AAAAAA
    FANCL NM_001114636.1 AGCGGACTGC GCATGTGCAG GACCCAGCAG GTCTAGAGCT 11
    TTTCTGTGTT TCTCCGGACT TCGAGCCATG GCGGTGACGG
    AAGCGAGCCT GTTGCGCCAG TGCCCCCTGC TTCTGCCCCA
    GAACCGGTCG AAAACCGTGT ATGAGGGATT CATCTCGGCT
    CAGGGAAGAG ACTTCCACCT TAGGATAGTG TTGCCTGAAG
    ATTTACAACT GAAGAATGCA AGATTATTAT GTAGTTGGCA
    GCTGAGAACA ATACTTAGTG GATACCATCG AATAGTACAA
    CAGAGAATGC AGCACTCTCC TGATCTAATG AGCTTTATGA
    TGGAGTTGAA GATGCTTTTG GAAGTTGCCT TAAAGAATAG
    ACAAGAGCTG TATGCACTAC CTCCTCCTCC CCAGTTCTAC
    TCAAGCCTTA TTGAAGAGAT AGGAACTCTT GGTTGGGATA
    AACTTGTGTA TGCGGATACC TGCTTCAGTA CCATCAAGTT
    AAAAGCAGAA GATGCTTCTG GTAGAGAGCA TTTAATCACT
    CTCAAGTTGA AGGCAAAGTA TCCTGCAGAA TCACCAGATT
    ATTTTGTGGA TTTTCCTGTT CCATTTTGTG CCTCCTGGAC
    ACCTCAGGTA AATTCTCCTC AGAGCTCCTT AATAAGCATT
    TATAGTCAGT TTTTGGCAGC AATAGAATCA CTAAAGGCAT
    TCTGGGATGT TATGGATGAA ATCGATGAGA AGACCTGGGT
    ACTTGAGCCA GAAAAACCTC CACGGAGTGC AACAGCACGC
    AGAATTGCAT TAGGTAATAA TGTTTCCATA AATATAGAGG
    TAGACCCCAG GCATCCTACT ATGCTTCCTG AGTGCTTCTT
    TCTTGGAGCT GACCATGTGG TAAAACCCCT GGGAATTAAG
    CTGAGCAGGA ACATACATTT GTGGGATCCA GAAAATAGTG
    TGTTACAAAA TTTGAAAGAT GTTTTAGAAA TTGATTTTCC
    AGCTCGTGCT ATCCTGGAAA AATCTGATTT TACTATGGAT
    TGTGGAATTT GTTATGCTTA TCAACTTGAC GGTACCATTC
    CTGATCAAGT GTGTGATAAT TCTCAGTGTG GACAACCTTT
    CCATCAAATA TGCTTATATG AGTGGCTGAG AGGACTACTA
    ACTAGTAGAC AGAGTTTTAA CATCATATTT GGTGAATGTC
    CATATTGTAG TAAGCCAATT ACCTTAAAAA TGTCTGGAAG
    GAAACACTGA AATAAGAATA CAACATTTCG GTGAAGAGCT
    GGAAACTTAA AAAATTATCA AAAGGAATTT TGGTATCATC
    TTCAGAGAAA AAATAAAGCA AGAAATACTA ACATCAAAAG
    GACAGGTATG ATGATGCGAT AATAATAAAC ATCTGCGTTT
    GTCTCTTCAC TAAGAGTAAA CTGGGAAATT GTAGGCCAAA
    GTCCAGTTGA ACTTTCTAAG TCTGTGATCC CCGTGCTGAC
    TGTGGAAGTG TATTTATACC AAGATGGAGA TCTTGACTTC
    TTGAATATAT CTGGACTGGT AAAATCTTGA TGAGGCTCAT
    AAAATGAGTT TGGGAATTGT GTATAGCTGA TTTTTTGTGG
    GAAACTGTTT ACTTCATTCA AAGGTTCTTG AGACTCTTGA
    TATTTCTGTC TTCTCCTTGT GCTTTCCTAT GGAAAAAATA
    CATATATAGT TTAGTTTGTT AGACGTGAGT TATCCAAGTA
    TTTATTTTGT GTAGTGTGTA AGAATGCTAA ATAAAATGTT
    ATACAAGATC AAAAAAAAAA AAAAAAAAAA AAA
    HJURP NM_018410.4 CTATTTGAGT TTGTGGCGCG CGAGGCCCTG CAGTCCGGGT 12
    TGGCGCTTGG GTACTGGCTG GGTCCGATGC TGGGTACGCT
    GCGCGCCATG GAGGGCGAGG ACGTGGAAGA CGACCAGCTG
    CTGCAGAAGC TCAGGGCCAG TCGCCGCCGC TTCCAGAGGC
    GCATGCAGCG GCTGATAGAG AAGTACAACC AGCCCTTCGA
    GGACACCCCG GTGGTGCAAA TGGCCACGCT GACCTACGAG
    ACGCCACAGG GATTGAGAAT TTGGGGTGGA AGACTAATAA
    AGGAAAGAAA CGAAGGAGAG ATCCAGGACT CCTCCATGAA
    GCCCGCGGAC AGGACAGATG GCTCCGTGCA AGCTGCAGCC
    TGGGGTCCTG AGCTTCCCTC GCACCGCACA GTCCTGGGAG
    CCGATTCAAA AAGCGGTGAG GTCGATGCCA CGTCAGACCA
    GGAAGAGTCA GTTGCTTGGG CCTTAGCACC TGCAGTGCCT
    CAAAGCCCTT TGAAAAATGA ATTAAGAAGG AAATACTTGA
    CCCAAGTGGA TATACTGCTA CAAGGTGCAG AGTATTTTGA
    GTGTGCAGGT AACAGAGCTG GAAGGGATGT ACGTGTGACT
    CCGCTGCCTT CACTGGCCTC ACCTGCCGTG CCTGCCCCCG
    GATACTGCAG TCGTATCTCC AGAAAGAGTC CTGGTGACCC
    AGCGAAACCA GCTTCATCTC CCAGAGAATG GGATCCTTTG
    CATCCTTCCT CCACAGACAT GGCCTTAGTA CCTAGAAATG
    ACAGCCTCTC CCTACAAGAG ACCAGTAGCA GCAGCTTCTT
    AAGCAGCCAG CCCTTTGAAG ATGATGACAT TTGCAATGTG
    ACCATCAGTG ACCTGTACGC AGGGATGCTG CACTCCATGA
    GCCGGCTGTT GAGCACAAAG CCATCAAGCA TCATCTCCAC
    CAAAACGTTC ATCATGCAAA ACTGGAACTC CAGGAGGAGG
    CACAGATATA AGAGCAGGAT GAACAAAACA TATTGCAAAG
    GAGCCAGACG TTCTCAGAGG AGCTCCAAGG AGAACTTCAT
    ACCCTGCTCT GAGCCTGTGA AAGGGACAGG GGCATTAAGA
    GATTGCAAGA ACGTATTAGA TGTTTCTTGC CGTAAGACAG
    GTTTAAAATT GGAAAAAGCT TTTCTTGAAG TCAACAGACC
    CCAAATCCAT AAGTTAGATC CAAGTTGGAA GGAGCGCAAA
    GTGACACCCT CGAAGTATTC TTCCTTGATT TACTTCGACT
    CCAGTGCAAC ATATAATCTT GATGAGGAAA ATAGATTTAG
    GACATTAAAA TGGTTAATTT CTCCTGTAAA AATAGTTTCC
    AGACCAACAA TACGACAGGG CCATGGAGAG AACCGTCAGA
    GGGAGATTGA AATCCGATTT GATCAGCTTC ATCGGGAATA
    TTGCCTGAGT CCCAGGAACC AGCCTCGCCG GATGTGCCTC
    CCGGACTCCT GGGCCATGAA CATGTACAGA GGGGGTCCTG
    CGAGTCCTGG TGGCCTTCAG GGCTTAGAAA CCCGCAGGCT
    GAGTTTACCT TCCAGCAAAG CAAAAGCAAA AAGTTTAAGT
    GAGGCTTTTG AAAACCTAGG CAAAAGATCT CTGGAAGCAG
    GTAGGTGCCT GCCCAAGAGC GATTCATCTT CATCACTTCC
    AAAGACCAAC CCCACACACA GCGCAACTCG CCCGCAGCAG
    ACATCTGACC TTCACGTTCA GGGAAATAGT TCTGGAATAT
    TTAGAAAGTC AGTGTCACCC AGCAAAACTC TTTCAGTCCC
    AGATAAAGAA GTGCCAGGCC ACGGAAGGAA TCGTTACGAT
    GAAATTAAAG AAGAATTTGA CAAGCTTCAT CAAAAGTATT
    GCCTCAAATC TCCTGGGCAG ATGACAGTGC CTTTATGTAT
    TGGAGTGTCT ACAGATAAAG CAAGTATGGA AGTTCGATAT
    CAAACAGAAG GCTTCTTAGG AAAATTAAAT CCAGACCCTC
    ACTTCCAGGG TTTCCAGAAG TTGCCATCAT CACCCCTGGG
    GTGCAGAAAA AGTCTACTGG GCTCAACTGC AATTGAGGCT
    CCTTCATCTA CATGTGTTGC TCGTGCCATC ACGAGGGATG
    GCACGAGGGA CCATCAGTTC CCTGCAAAAA GACCCAGGCT
    ATCAGAACCC CAGGGCTCCG GACGCCAGGG CAATTCCCTG
    GGTGCCTCAG ATGGGGTGGA CAACACCGTC AGACCGGGAG
    ACCAGGGCAG CTCTTCACAG CCCAACTCAG AAGAGAGAGG
    AGAGAACACG TCTTACAGGA TGGAAGAGAA AAGTGATTTC
    ATGCTAGAAA AATTGGAAAC TAAAAGTGTG TAGCTAGGTT
    ATTTCGGAGT GTTATTTATC TTCCCACTTG CTCTCTGTTT
    GTATTTTTGT TTTGTTTTTG ATTCTTGAGA CTGTGAGGAC
    TTGGTTGACT TCTCTGCCCT TAAAGTAAAT ATTAGTGAAA
    TTGGTTCCAT CAGAGATAAC CTCGAGTTCT TGGTGTAGAA
    ATTATGTGAA TAAAGTTGCT CAATTAGAAT TTTTAGGGTT
    CTCTTTGATA GGCCTGTTTT TCTGATGTGT GTGTTTTTTT
    TGGGGGGGGG TTATTTGTTT GTTTGTTTGT TTGTTTGTTT
    GTTTTTGAGA CAGTCTCTCT CTATCGCCCA GGCTGGAGTG
    CGGTGGCACA ATCTTGGCTC ACTGCAACTT CCGCCTCCCG
    GGTTCAAGCG ATTCTTCTGC CTCAGCCTCC CGAGTAGCTG
    GGATTACAGG CGCGCGCCAC CACGCCTGGC TAATTTTTGT
    AGTTTTAGTA GAGACGGGGT TTCACCATAT TGACCAGGCT
    GGTCTCGAGC TCCTGGCCTC GTGATCCATC TGCCTCGGCC
    TCCCAAAGTG CTGGGATTAT AGGCGTGAGC CACTGCTCCC
    AGCCGTGTGT TCTTTTTTAA ATTTAGATAT GTCCAGAGAA
    TCCTCTCTCC TGTTTCCCAT TTCATTCGAG AATATTGTTT
    GCTTGTGAGA CGTAAGTTCG AGCCCTGCAT GCAATGACCC
    TTGAAGGAAA ATAAACAGTC CTGGTGGTCC CAGACGCTCC
    TGCAGCCACA GCGCCTGTGA CTCCTCATGA TTCTTACTGA
    AGCTGTTGAT GACAGGATAT CATGGTGACG TTTTTGTAAT
    GAAATATTTC ACATATTCAG AATACATTGG TGAAACTCAT
    GCTGGAGTAA ATAGTTAATA TATGGCCAT
    HLA- NM_002119.3 CTTCTTCTTT ACCTCCGCCT TGTTCCTGTC CTCACCACAC 13
    DOA GGACTGAGAC TGATTTGATT AAAGCACCAG AGTGTAATGG
    CCCTCAGAGC AGGGCTGGTC CTGGGGTTCC ACACCCTGAT
    GACCCTCCTG AGCCCGCAGG AGGCAGGGGC CACCAAGGCT
    GACCACATGG GCTCCTACGG ACCCGCCTTC TACCAGTCTT
    ACGGCGCCTC GGGCCAGTTC ACCCATGAAT TTGATGAGGA
    ACAGCTGTTC TCTGTGGACC TGAAGAAAAG CGAGGCCGTG
    TGGCGTCTGC CTGAGTTTGG TGACTTTGCC CGCTTTGACC
    CGCAGGGCGG GCTGGCCGGC ATCGCCGCAA TCAAAGCCCA
    TCTGGACATC CTGGTGGAGC GCTCCAACCG CAGCAGAGCC
    ATCAACGTGC CTCCACGGGT GACCGTGCTC CCCAAGTCTC
    GGGTGGAGCT GGGCCAGCCC AACATCCTCA TCTGCATCGT
    GGACAACATC TTCCCCCCTG TGATCAATAT CACCTGGCTG
    CGCAACGGCC AAACTGTCAC TGAGGGAGTG GCCCAGACCA
    GCTTCTATTC CCAGCCTGAC CATTTGTTCC GCAAGTTCCA
    CTACCTGCCC TTCGTGCCCT CAGCCGAGGA CGTCTATGAC
    TGCCAGGTGG AGCACTGGGG CCTGGATGCG CCACTCCTCA
    GGCATTGGGA GCTCCAGGTG CCTATTCCAC CACCAGATGC
    CATGGAGACC CTGGTCTGTG CCCTGGGCCT GGCCATCGGC
    CTGGTGGGCT TCCTCGTGGG CACCGTCCTC ATCATCATGG
    GCACATATGT GTCCAGTGTC CCCAGGTAAT GATCCTTCTG
    AGAGAAATGA CTTGTGGGAG ACACCCTGCA GATCCTCATG
    GGTTTGTGAC AGCCCCTGCG TGCTCAGTGC CCTTTAAGTG
    CATCCCGCTG TGCTGACTTT GAGTGGGATC AACATCTGTC
    CTACGGGTCC CCTCTTTTTT GGCCCCAGTA TTCATGGCAG
    GGTTTGTTGG ACACCTACTA GCTTCCCTTC CCATTCAACA
    CACACACACA TTCTTGCTCT ACCCAAAGCT CTGGCTGGCA
    GCACTAAATG CTTTGGTGGT GTTTGCACTG TGTCCTTTCC
    AGGCCTTGGC CAGTTCTTCC AGGGGTGAGG CATGTGGTGC
    TGGGGATTGG CAGCCATCCT GGGGCCCACA CAGGTGTGTC
    TTGCTCCATT TGGCCCATTG TGTGTTACTT TGTGAATGAG
    CCATTTCACA TGGACTTCAT GAAATTTGCC TCCTGAGTTC
    AGGTTTACCC TGAAAGGGAT GCAGATTATC CTGTTCCTCA
    CGACCCCCTC AGCTAACAAC AGTTCTGAAG GGTGCTGGGA
    CAGGACAGGC TCATGGGGAC TCCACTCCTG CCTGGGTTTA
    CTCTGTATGA AGAGGCCACT GGTATCCTGC CATGATGTTA
    TCTCCTTTTT CTACTTTTCC CTAGAGTCCC ATGCATGATA
    AAGAGAGGCC CAAGGCTTGG ATAAGGTGGC CACTTCCCTC
    AGTGGAGTCA GTCATGTTAG GTAGGAGGTG GTAGAGTCGG
    TCTGCGAGGT ATCTCGTAAG AGGGGAGGTC CACCTAGACA
    CACTCTAAAT ATGTGGCCTA GAAGATTTTG GTCTACTTTT
    CTGTGAACAG AATTTAAAAC ATACAAAGAG ATAAATCACC
    ATACCACATA GTTTATGTCA GGACCAAAAT GAGCAATACA
    GATTACGGTT TTCAAACCAG AATGCACATA AGAACTGCTT
    GGGATCCTTT TAAAAGTACA GGCATTGGCC TGGTGCAGTG
    GCTCATTCCT GTAATCCCAG CACTTTGGGA GGCCAAGGGG
    ACAGGACTGC TTGAGGCCAA GAGGTGGAAA CCATCTTGGG
    CTACATAGAG AGACCCCATC TCTACAAAGA AAGATTTAAA
    AATTAACCAG GCATGGTGGC TCGCACCTGT ATTCCCAGCC
    ACTGGGGAGG CTGAGGCCGG AGGAGTGCTT GAGCCCAGGA
    GTTCAAGGCT GCAGTGAGCC AAGATTGCGC CACTGCACTC
    CAGCCTAGGT GACAGAGTGA GACCCTGTCT CTAAATAAAT
    AAATAAATAA AATATAAAAA TAACAGTCAT CACCCAGACC
    TACTGAATTA GAATCTCGGG AGTGCAGGGG GCAGCAACAG
    GGAGGCTGTC TTTTCTGAGA TGGGGTCTCA CTCTGTCACC
    AGGCTGGAGT GCCATGGCAT GATCTCAGCT CACTGCAACC
    TCCACCTCCT GAGTTCAAGC CATTCTCCTG CCTCAGCCTC
    CTGAGTAGCT GGGACTACAG GTGTGCGCCA CTACACTCAG
    CTAATTTTTG TATTTTAAGT AGAGACGGGG TTTCATCATG
    TTGGCCAGGA TGGCCTCCAT CTCTTGACCT CGTGATCCAC
    CCACCTTCCC TCCCAAAGTA CTGGAATTAC AGGCATTAGC
    CACTGTGCCC AGCCGAGGCT GTCATTTTTA ACCGGCTCTG
    GATGACTCTG ATGCAGCCAT CCTGGACCTT GGCTGTGGTC
    TGGTAACTGG AACCCAGTGA CGTAATCAGG TGCCATCGGG
    GGTCATGGGA AAGGGGGATC CCCAAGGTCT GAGGTGGACT
    AGGAAGGCTT TCTGAAGAAC CTGGGTCTGT TAGGGCATCA
    GCCAATCAAG GTACAAGTAA ATAGAGGCAA AATGAGGGTT
    TGAACTGTGA GCAGTTGGTC CTGGAAAAGA AAGAAACCAA
    GAGATTATGG GGACTCAATG GGCTTCTTAA GAGAGAATAA
    GTTGAAATCA ATGACCAGAA GACCCTGATG GAAGTGGAGG
    AGAATCATCT CAGGCAAACT TTTTGTGTGC CAGTAACAGA
    AACCCTCTTT GTGTGATCAC ATGCAAAGTA TAGGATATTT
    GCAATATAGC CATGGGGAGG AGTGCAGGGC CCAAGGGTAG
    ATTTTAGCCA GGCCTCCCAG GAACAGAACT CGGATCCGAA
    AAGCCCAGAG AAGCTAGAGC TGCCCCTCCA ACACTCTCGG
    ATCCACATGG TCTGTGTTCT CTAGACCCCC CTGCATGTTA
    GCGGTGTTCT CTCTCTGTGG ACTGACTGTC CTTCTCAGTG
    AACATGTCCA CCCGACAGCT CCTGAGTTTA TATCATCTCA
    ACCCTCACAA CCCACAGAGG CTGTGTCTCC TAGTCACAGC
    TTTAAATTAC TGGAAAAATA AATGACTGGC CAAACTTGGA
    GCAGGTGTCC ATCCCAGCCC TGTGTAGTTA GAGCAGGAAT
    CAAGATCTCA ACACAAATGT GGCTGCCAAG CACTCAGCCC
    CGGGGCGAGG GGTCAAGTTC TTCTCAGAGA AAGAGGAATA
    AGTTGGTTCT CAGAAGACAT CACAAGATAC GTGTGTACCC
    AACAATCTCT GATCTCTGCT GATCTTTTGC TTAGACGTTA
    ACTTGATGCA TCATTGGAAA GGTGTTTCTC TCATCTCTGT
    CCTAAGGCTT GATAAAGTCA TTAAAATTGT GTTCTTTTGA
    CTAAA
    HLA- NM_019111.4 TTTTAATGGT CAGACTCTAT TACACCCCAC ATTCTCTTTT 14
    DRA CTTTTATTCT TGTCTGTTCT GCCTCACTCC CGAGCTCTAC
    TGACTCCCAA CAGAGCGCCC AAGAAGAAAA TGGCCATAAG
    TGGAGTCCCT GTGCTAGGAT TTTTCATCAT AGCTGTGCTG
    ATGAGCGCTC AGGAATCATG GGCTATCAAA GAAGAACATG
    TGATCATCCA GGCCGAGTTC TATCTGAATC CTGACCAATC
    AGGCGAGTTT ATGTTTGACT TTGATGGTGA TGAGATTTTC
    CATGTGGATA TGGCAAAGAA GGAGACGGTC TGGCGGCTTG
    AAGAATTTGG ACGATTTGCC AGCTTTGAGG CTCAAGGTGC
    ATTGGCCAAC ATAGCTGTGG ACAAAGCCAA CCTGGAAATC
    ATGACAAAGC GCTCCAACTA TACTCCGATC ACCAATGTAC
    CTCCAGAGGT AACTGTGCTC ACAAACAGCC CTGTGGAACT
    GAGAGAGCCC AACGTCCTCA TCTGTTTCAT AGACAAGTTC
    ACCCCACCAG TGGTCAATGT CACGTGGCTT CGAAATGGAA
    AACCTGTCAC CACAGGAGTG TCAGAGACAG TCTTCCTGCC
    CAGGGAAGAC CACCTTTTCC GCAAGTTCCA CTATCTCCCC
    TTCCTGCCCT CAACTGAGGA CGTTTACGAC TGCAGGGTGG
    AGCACTGGGG CTTGGATGAG CCTCTTCTCA AGCACTGGGA
    GTTTGATGCT CCAAGCCCTC TCCCAGAGAC TACAGAGAAC
    GTGGTGTGTG CCCTGGGCCT GACTGTGGGT CTGGTGGGCA
    TCATTATTGG GACCATCTTC ATCATCAAGG GATTGCGCAA
    AAGCAATGCA GCAGAACGCA GGGGGCCTCT GTAAGGCACA
    TGGAGGTGAT GGTGTTTCTT AGAGAGAAGA TCACTGAAGA
    AACTTCTGCT TTAATGGCTT TACAAAGCTG GCAATATTAC
    AATCCTTGAC CTCAGTGAAA GCAGTCATCT TCAGCATTTT
    CCAGCCCTAT AGCCACCCCA AGTGTGGATA TGCCTCTTCG
    ATTGCTCCGT ACTCTAACAT CTAGCTGGCT TCCCTGTCTA
    TTGCCTTTTC CTGTATCTAT TTTCCTCTAT TTCCTATCAT
    TTTATTATCA CCATGCAATG CCTCTGGAAT AAAACATACA
    GGAGTCTGTC TCTGCTATGG AATGCCCCAT GGGGCATCTC
    TTGTGTACTT ATTGTTTAAG GTTTCCTCAA ACTGTGATTT
    TTCTGAACAC AATAAACTAT TTTGATGATC TTGGGTGGAA
    AAAAAAAAAA AAAAAAAAAA AAAAAAAAAA AA
    HNRNPA3P1 NR_002726.2 CGAGTTGGAA GAGGTGAGTC CTGTCTCAAA ATGGAGGTAA 15
    AACCGCCGCC TGGTTGCCCC CAGCCCGACT CCGGCAGTCG
    CCGTCGCCAC TGGGGGGAGG AGGGCCATGA TCCAAAGGAA
    CCAGAGCAGC TGAGAAAACT GTTTATTGGT GGTCTGAGCT
    TTGAAACTAC AGATGATAGT TTAAGAGAAC ATTTTGAGAA
    ATGGGGCACA CTCACAGATT GTCTGGTAAT GAGAGACCCC
    CAAACAAAAC GTTCCAGGGG CTTTGGTTTT GTGACTTATT
    CTTGTGTTAC AGAGGTGGAT GCAGCAATGC GTGCTCGACC
    ATTCAAGGTT GATGGGCGTG TAGTGGAACC AAAGAGAGCT
    GTTTCTAGAG AGGATTCTGT GAAGCCTGGT GCCCATCTAA
    CAGTGAAGAA AATTTTTGTT GGCAGTATTA AAGAAGATAC
    AGAAGAATAT AATTTGAGAG ACTACTTTGA AAAGTACGGC
    AAGATTGAAA CCATAGAAGT TATGGAAGAC AGGCAGAGTG
    GAAAAAAGAG AGGATTTGCT TCTGTAACTT TTGATGATCA
    TGATACAGTT GATAAAATTG TTGTTCAGAA ATACCACACT
    ATTAATGGGC ATAACTGTGA AGTGAAAAAG GCCCTTGCTA
    AACAAGTGAT GCAGCCGGCT GGATCACAGA GGGGTCGTGG
    AGGTGGATCT GGCAATTGTA TGGGTCACAG AGGAAACTTT
    GGAGGTGGTG GAGGTAATTT TGGCCGTGAT GGAAACTTTG
    GTGGAAGAGG AGGCTATGGT GGTGGAGGTG GTGGCAGCAG
    AGGTAGTTAT GGAGGAGGTG ATGTGGATAT AATGGATTAG
    GAGGTGATGG TGGCAACTAT GGCAGTGGTC CTGGTTATAG
    TAGTAGAGGC GGGTATGGTG GTGGTGGACC AGGATATGGA
    AACCAAGGTG GTGGATATGG TGGCGGTGTT GGAGGATATG
    ATGGTTACAA TGAAGGAGGA AATTTTGACG GTAGTAACTA
    TGGTGGTGGT GGGAACTATA ATGATTTTGG AAATTACAGT
    GGACAACAGC AATCAAATTA TGGACACATG AAAGGGGGCA
    GTTTTGGTGG AAGAAGCTCG GGCAGTCCCT ATGGTGGTGG
    TTATGGATCT GGTGGTGGAA GTGGTGGATA TGGTAGCAGA
    AGGTTCTAAA AACAGCAGGA AAGGGCTACA GTTCTTAGCA
    GGAGAGAGAG TGAGGAGTTG TCAGGAAAGC TACAGGTTAC
    TTTGAGACAG TCGTCCCAAG TGCATTAGAG GAACTGTAAA
    AATCTGTCAC AGAAGGAACG ATGATCCATA ATCAGAAAAG
    TTACTGCAGC TTAAACAGGA AACCCTTCTT GTTCAGGACT
    GTCATAGCCA CAGTTTGCAG GAAGTGCAGC TATCGATTAA
    TGCAATGTAG CGTCAATTAG ATGTACATTC CTCAGGTCTT
    TTATCTGTTG TAGCTTTGTC TTATTCTTTT TCTTTTCATT
    ACATCAGGTA TATTGCCCTG TAAATTGTGG TAGTGGTACC
    AGGAATAAAA AATTAAGGAA TTTTTAACTT TTCAATATCT
    GTGTAGTTCA GTTTTTCTAC ATTTTAGTAC AGAAACTTTA
    ACAAAATGCA GTTTTGAAGG TGTTTCCTTG TGAGTTAACA
    AGTAAAGAAG ATCAATTGTT AATTACTATT TTGTATAAAT
    TTTGCTAAAG TTAACTGTAA AGAAACACCT GCTGACTTGC
    AGTTTAAGGG GAATCTATTC TCCCCATTTC CAAACCATGA
    TATGAATGGA CGCCGACATG TGGAGAGAAC AGATAATTTG
    TGTGTTTGCA ATGTGTGTTT TAGGTAAATA GGATTGGGTA
    TTTAAATTAG CATTTGTGAA TTTAATAGCA TTAAGATTAC
    CTTCAAATAA AAAAGTCTCA AAATTTCTTT TTGGTTTTTG
    TGCACTTTCT TTTAAAATGT AATCACATGA TTTTAGTGTG
    TTAGACTTGC TGAGTCCTAG CTGTGTTTAG AACATCTCCA
    TTCTACATTT ACCTTGGTCA AATTTGAACT GCTGCCATAG
    GTTTTGGGTG TAAAGAATGT TTACTGCCCT CCATTTAAAT
    TCTGAAAAGG TATAGTGGAT GTTTTCCCTC TCCTACATTA
    GAAACCATTC TTAAAAACTT TTCAAAATAT AGAACCATTA
    AGCCTGCTAT ATCTGAGCAA ATTAGTGGGT ACCTTTTTTC
    CTTTTTTAAA GCACAAGAGG CCCATAAATC TTGAGTTATT
    TGCATTAGTT TACATTTTTT GATACAACTT TTCAGACCAA
    GAGAATAAAA ATCATGCGTT ATTAAACCCC TAGCTGGCTG
    GCATGCTTTC CTGTTTGTAC TGTATACATT TTGCTGGATG
    AAACCAAGGA TAGTTTAGGT ATAATTGTCC AAAATAACCT
    AACTGCAGCA GAAATGTAGG ACAGTTGCTT AGTACAGGCT
    TCTCACTTCC TACAGACCTG AATTCAAATT TGGATAGTCT
    GAGTTATTAA ATTCCCAAAG ACAAAGAACA CACTCTTATT
    TCTTGTGTAT ATTTCAACAT AAATCATGTT GTTACCAATT
    TGTTGGGAAG GCCCTGGTTG AGAAGAGTTT TAGATAATAA
    GGCTGTATAT ATATAGATAT ATATAGATAT ATACCAATGT
    CTATATATAG AGATATTTTA TATATATATA TACAGGTATA
    TATATGTGTG TGTATATATA TAGGTATATA CATATATACA
    TATATATATA TATATATATG GATATATACC CATGTCTACT
    GTTTTGCTTC AGCTAGTGCT TACAATTTCA TTCAAGTCCT
    GAGTATGTGT CCTGCTGTTA CTCCTTCTTT GGTAGTTGAA
    CGTTGAATTC AAGTCTTTCC TTCTGTTTTA AGAAGTACTA
    AGCAAACAAG CAATAAAAAG GGGAATGGCG CATGCTAGTG
    TTTGAATATG CTCTCTTGTT GCTCTAATTC TGTGCCTCCG
    TGCATTAATA TTTGGATGCA TGCAATGCCA GCATGGAAAT
    TGGCCT
    IL23A NM_016584.2 AAAACAACAG GAAGCAGCTT ACAAACTCGG TGAACAACTG 16
    AGGGAACCAA ACCAGAGACG CGCTGAACAG AGAGAATCAG
    GCTCAAAGCA AGTGGAAGTG GGCAGAGATT CCACCAGGAC
    TGGTGCAAGG CGCAGAGCCA GCCAGATTTG AGAAGAAGGC
    AAAAAGATGC TGGGGAGCAG AGCTGTAATG CTGCTGTTGC
    TGCTGCCCTG GACAGCTCAG GGCAGAGCTG TGCCTGGGGG
    CAGCAGCCCT GCCTGGACTC AGTGCCAGCA GCTTTCACAG
    AAGCTCTGCA CACTGGCCTG GAGTGCACAT CCACTAGTGG
    GACACATGGA TCTAAGAGAA GAGGGAGATG AAGAGACTAC
    AAATGATGTT CCCCATATCC AGTGTGGAGA TGGCTGTGAC
    CCCCAAGGAC TCAGGGACAA CAGTCAGTTC TGCTTGCAAA
    GGATCCACCA GGGTCTGATT TTTTATGAGA AGCTGCTAGG
    ATCGGATATT TTCACAGGGG AGCCTTCTCT GCTCCCTGAT
    AGCCCTGTGG GCCAGCTTCA TGCCTCCCTA CTGGGCCTCA
    GCCAACTCCT GCAGCCTGAG GGTCACCACT GGGAGACTCA
    GCAGATTCCA AGCCTCAGTC CCAGCCAGCC ATGGCAGCGT
    CTCCTTCTCC GCTTCAAAAT CCTTCGCAGC CTCCAGGCCT
    TTGTGGCTGT AGCCGCCCGG GTCTTTGCCC ATGGAGCAGC
    AACCCTGAGT CCCTAAAGGC AGCAGCTCAA GGATGGCACT
    CAGATCTCCA TGGCCCAGCA AGGCCAAGAT AAATCTACCA
    CCCCAGGCAC CTGTGAGCCA ACAGGTTAAT TAGTCCATTA
    ATTTTAGTGG GACCTGCATA TGTTGAAAAT TACCAATACT
    GACTGACATG TGATGCTGAC CTATGATAAG GTTGAGTATT
    TATTAGATGG GAAGGGAAAT TTGGGGATTA TTTATCCTCC
    TGGGGACAGT TTGGGGAGGA TTATTTATTG TATTTATATT
    GAATTATGTA CTTTTTTCAA TAAAGTCTTA TTTTTGTGGC
    TAAAAAAAA
    IQGAP1 NM_003870.3 GGACCCCGGC AAGCCCGCGC ACTTGGCAGG AGCTGTAGCT 17
    ACCGCCGTCC GCGCCTCCAA GGTTTCACGG CTTCCTCAGC
    AGAGACTCGG GCTCGTCCGC CATGTCCGCC GCAGACGAGG
    TTGACGGGCT GGGCGTGGCC CGGCCGCACT ATGGCTCTGT
    CCTGGATAAT GAAAGACTTA CTGCAGAGGA GATGGATGAA
    AGGAGACGTC AGAACGTGGC TTATGAGTAC CTTTGTCATT
    TGGAAGAAGC GAAGAGGTGG ATGGAAGCAT GCCTAGGGGA
    AGATCTGCCT CCCACCACAG AACTGGAGGA GGGGCTTAGG
    AATGGGGTCT ACCTTGCCAA ACTGGGGAAC TTCTTCTCTC
    CCAAAGTAGT GTCCCTGAAA AAAATCTATG ATCGAGAACA
    GACCAGATAC AAGGCGACTG GCCTCCACTT TAGACACACT
    GATAATGTGA TTCAGTGGTT GAATGCCATG GATGAGATTG
    GATTGCCTAA GATTTTTTAC CCAGAAACTA CAGATATCTA
    TGATCGAAAG AACATGCCAA GATGTATCTA CTGTATCCAT
    GCACTCAGTT TGTACCTGTT CAAGCTAGGC CTGGCCCCTC
    AGATTCAAGA CCTATATGGA AAGGTTGACT TCACAGAAGA
    AGAAATCAAC AACATGAAGA CTGAGTTGGA GAAGTATGGC
    ATCCAGATGC CTGCCTTTAG CAAGATTGGG GGCATCTTGG
    CTAATGAACT GTCAGTGGAT GAAGCCGCAT TACATGCTGC
    TGTTATTGCT ATTAATGAAG CTATTGACCG TAGAATTCCA
    GCCGACACAT TTGCAGCTTT GAAAAATCCG AATGCCATGC
    TTGTAAATCT TGAAGAGCCC TTGGCATCCA CTTACCAGGA
    TATACTTTAC CAGGCTAAGC AGGACAAAAT GACAAATGCT
    AAAAACAGGA CAGAAAACTC AGAGAGAGAA AGAGATGTTT
    ATGAGGAGCT GCTCACGCAA GCTGAAATTC AAGGCAATAT
    AAACAAAGTC AATACATTTT CTGCATTAGC AAATATCGAC
    CTGGCTTTAG AACAAGGAGA TGCACTGGCC TTGTTCAGGG
    CTCTGCAGTC ACCAGCCCTG GGGCTTCGAG GACTGCAGCA
    ACAGAATAGC GACTGGTACT TGAAGCAGCT CCTGAGTGAT
    AAACAGCAGA AGAGACAGAG TGGTCAGACT GACCCCCTGC
    AGAAGGAGGA GCTGCAGTCT GGAGTGGATG CTGCAAACAG
    TGCTGCCCAG CAATATCAGA GAAGATTGGC AGCAGTAGCA
    CTGATTAATG CTGCAATCCA GAAGGGTGTT GCTGAGAAGA
    CTGTTTTGGA ACTGATGAAT CCCGAAGCCC AGCTGCCCCA
    GGTGTATCCA TTTGCCGCCG ATCTCTATCA GAAGGAGCTG
    GCTACCCTGC AGCGACAAAG TCCTGAACAT AATCTCACCC
    ACCCAGAGCT CTCTGTCGCA GTGGAGATGT TGTCATCGGT
    GGCCCTGATC AACAGGGCAT TGGAATCAGG AGATGTGAAT
    ACAGTGTGGA AGCAATTGAG CAGTTCAGTT ACTGGTCTTA
    CCAATATTGA GGAAGAAAAC TGTCAGAGGT ATCTCGATGA
    GTTGATGAAA CTGAAGGCTC AGGCACATGC AGAGAATAAT
    GAATTCATTA CATGGAATGA TATCCAAGCT TGCGTGGACC
    ATGTGAACCT GGTGGTGCAA GAGGAACATG AGAGGATTTT
    AGCCATTGGT TTAATTAATG AAGCCCTGGA TGAAGGTGAT
    GCCCAAAAGA CTCTGCAGGC CCTACAGATT CCTGCAGCTA
    AACTTGAGGG AGTCCTTGCA GAAGTGGCCC AGCATTACCA
    AGACACGCTG ATTAGAGCGA AGAGAGAGAA AGCCCAGGAA
    ATCCAGGATG AGTCAGCTGT GTTATGGTTG GATGAAATTC
    AAGGTGGAAT CTGGCAGTCC AACAAAGACA CCCAAGAAGC
    ACAGAAGTTT GCCTTAGGAA TCTTTGCCAT TAATGAGGCA
    GTAGAAAGTG GTGATGTTGG CAAAACACTG AGTGCCCTTC
    GCTCCCCTGA TGTTGGCTTG TATGGAGTCA TCCCTGAGTG
    TGGTGAAACT TACCACAGTG ATCTTGCTGA AGCCAAGAAG
    AAAAAACTGG CAGTAGGAGA TAATAACAGC AAGTGGGTGA
    AGCACTGGGT AAAAGGTGGA TATTATTATT ACCACAATCT
    GGAGACCCAG GAAGGAGGAT GGGATGAACC TCCAAATTTT
    GTGCAAAATT CTATGCAGCT TTCTCGGGAG GAGATCCAGA
    GTTCTATCTC TGGGGTGACT GCCGCATATA ACCGAGAACA
    GCTGTGGCTG GCCAATGAAG GCCTGATCAC CAGGCTGCAG
    GCTCGCTGCC GTGGATACTT AGTTCGACAG GAATTCCGAT
    CCAGGATGAA TTTCCTGAAG AAACAAATCC CTGCCATCAC
    CTGCATTCAG TCACAGTGGA GAGGATACAA GCAGAAGAAG
    GCATATCAAG ATCGGTTAGC TTACCTGCGC TCCCACAAAG
    ATGAAGTTGT AAAGATTCAG TCCCTGGCAA GGATGCACCA
    AGCTCGAAAG CGCTATCGAG ATCGCCTGCA GTACTTCCGG
    GACCATATAA ATGACATTAT CAAAATCCAG GCTTTTATTC
    GGGCAAACAA AGCTCGGGAT GACTACAAGA CTCTCATCAA
    TGCTGAGGAT CCTCCTATGG TTGTGGTCCG AAAATTTGTC
    CACCTGCTGG ACCAAAGTGA CCAGGATTTT CAGGAGGAGC
    TTGACCTTAT GAAGATGCGG GAAGAGGTTA TCACCCTCAT
    TCGTTCTAAC CAGCAGCTGG AGAATGACCT CAATCTCATG
    GATATCAAAA TTGGACTGCT AGTGAAAAAT AAGATTACGT
    TGCAGGATGT GGTTTCCCAC AGTAAAAAAC TTACCAAAAA
    AAATAAGGAA CAGTTGTCTG ATATGATGAT GATAAATAAA
    CAGAAGGGAG GTCTCAAGGC TTTGAGCAAG GAGAAGAGAG
    AGAAGTTGGA AGCTTACCAG CACCTGTTTT ATTTATTGCA
    AACCAATCCC ACCTATCTGG CCAAGCTCAT TTTTCAGATG
    CCCCAGAACA AGTCCACCAA GTTCATGGAC TCTGTAATCT
    TCACACTCTA CAACTACGCG TCCAACCAGC GAGAGGAGTA
    CCTGCTCCTG CGGCTCTTTA AGACAGCACT CCAAGAGGAA
    ATCAAGTCGA AGGTAGATCA GATTCAAGAG ATTGTGACAG
    GAAATCCTAC GGTTATTAAA ATGGTTGTAA GTTTCAACCG
    TGGTGCCCGT GGCCAGAATG CCCTGAGACA GATCTTGGCC
    CCAGTCGTGA AGGAAATTAT GGATGACAAA TCTCTCAACA
    TCAAAACTGA CCCTGTGGAT ATTTACAAAT CTTGGGTTAA
    TCAGATGGAG TCTCAGACAG GAGAGGCAAG CAAACTGCCC
    TATGATGTGA CCCCTGAGCA GGCGCTAGCT CATGAAGAAG
    TGAAGACACG GCTAGACAGC TCCATCAGGA ACATGCGGGC
    TGTGACAGAC AAGTTTCTCT CAGCCATTGT CAGCTCTGTG
    GACAAAATCC CTTATGGGAT GCGCTTCATT GCCAAAGTGC
    TGAAGGACTC GTTGCATGAG AAGTTCCCTG ATGCTGGTGA
    GGATGAGCTG CTGAAGATTA TTGGTAACTT GCTTTATTAT
    CGATACATGA ATCCAGCCAT TGTTGCTCCT GATGCCTTTG
    ACATCATTGA CCTGTCAGCA GGAGGCCAGC TTACCACAGA
    CCAACGCCGA AATCTGGGCT CCATTGCAAA AATGCTTCAG
    CATGCTGCTT CCAATAAGAT GTTTCTGGGA GATAATGCCC
    ACTTAAGCAT CATTAATGAA TATCTTTCCC AGTCCTACCA
    GAAATTCAGA CGGTTTTTCC AAACTGCTTG TGATGTCCCA
    GAGCTTCAGG ATAAATTTAA TGTGGATGAG TACTCTGATT
    TAGTAACCCT CACCAAACCA GTAATCTACA TTTCCATTGG
    TGAAATCATC AACACCCACA CTCTCCTGTT GGATCACCAG
    GATGCCATTG CTCCGGAGCA CAATGATCCA ATCCACGAAC
    TGCTGGACGA CCTCGGCGAG GTGCCCACCA TCGAGTCCCT
    GATAGGGGAA AGCTCTGGCA ATTTAAATGA CCCAAATAAG
    GAGGCACTGG CTAAGACGGA AGTGTCTCTC ACCCTGACCA
    ACAAGTTCGA CGTGCCTGGA GATGAGAATG CAGAAATGGA
    TGCTCGAACC ATCTTACTGA ATACAAAACG TTTAATTGTG
    GATGTCATCC GGTTCCAGCC AGGAGAGACC TTGACTGAAA
    TCCTAGAAAC ACCAGCCACC AGTGAACAGG AAGCAGAACA
    TCAGAGAGCC ATGCAGAGAC GTGCTATCCG TGATGCCAAA
    ACACCTGACA AGATGAAAAA GTCAAAATCT GTAAAGGAAG
    ACAGCAACCT CACTCTTCAA GAGAAGAAAG AGAAGATCCA
    GACAGGTTTA AAGAAGCTAA CAGAGCTTGG AACCGTGGAC
    CCAAAGAACA AATACCAGGA ACTGATCAAC GACATTGCCA
    GGGATATTCG GAATCAGCGG AGGTACCGAC AGAGGAGAAA
    GGCCGAACTA GTGAAACTGC AACAGACATA CGCTGCTCTG
    AACTCTAAGG CCACCTTTTA TGGGGAGCAG GTGGATTACT
    ATAAAAGCTA TATCAAAACC TGCTTGGATA ACTTAGCCAG
    CAAGGGCAAA GTCTCCAAAA AGCCTAGGGA AATGAAAGGA
    AAGAAAAGCA AAAAGATTTC TCTGAAATAT ACAGCAGCAA
    GACTACATGA AAAAGGAGTT CTTCTGGAAA TTGAGGACCT
    GCAAGTGAAT CAGTTTAAAA ATGTTATATT TGAAATCAGT
    CCAACAGAAG AAGTTGGAGA CTTCGAAGTG AAAGCCAAAT
    TCATGGGAGT TCAAATGGAG ACTTTTATGT TACATTATCA
    GGACCTGCTG CAGCTACAGT ATGAAGGAGT TGCAGTCATG
    AAATTATTTG ATAGAGCTAA AGTAAATGTC AACCTCCTGA
    TCTTCCTTCT CAACAAAAAG TTCTACGGGA AGTAATTGAT
    CGTTTGCTGC CAGCCCAGAA GGATGAAGGA AAGAAGCACC
    TCACAGCTCC TTTCTAGGTC CTTCTTTCCT CATTGGAAGC
    AAAGACCTAG CCAACAACAG CACCTCAATC TGATACACTC
    CCGATGCCAC ATTTTTAACT CCTCTCGCTC TGATGGGACA
    TTTGTTACCC TTTTTTCATA GTGAAATTGT GTTTCAGGCT
    TAGTCTGACC TTTCTGGTTT CTTCATTTTC TTCCATTACT
    TAGGAAAGAG TGGAAACTCC ACTAAAATTT CTCTGTGTTG
    TTACAGTCTT AGAGGTTGCA GTACTATATT GTAAGCTTTG
    GTGTTTGTTT AATTAGCAAT AGGGATGGTA GGATTCAAAT
    GTGTGTCATT TAGAAGTGGA AGCTATTAGC ACCAATGACA
    TAAATACATA CAAGACACAC AACTAAAATG TCATGTTATT
    AACAGTTATT AGGTTGTCAT TTAAAAATAA AGTTCCTTTA
    TATTTCTGTC CCATCAGGAA AACTGAAGGA TATGGGGAAT
    CATTGGTTAT CTTCCATTGT GTTTTTCTTT ATGGACAGGA
    GCTAATGGAA GTGACAGTCA TGTTCAAAGG AAGCATTTCT
    AGAAAAAAGG AGATAATGTT TTTAAATTTC ATTATCAAAC
    TTGGGCAATT CTGTTTGTGT AACTCCCCGA CTAGTGGATG
    GGAGAGTCCC ATTGCTAAAA TTCAGCTACT CAGATAAATT
    CAGAATGGGT CAAGGCACCT GCCTGTTTTT GTTGGTGCAC
    AGAGATTGAC TTGATTCAGA GAGACAATTC ACTCCATCCC
    TATGGCAGAG GAATGGGTTA GCCCTAATGT AGAATGTCAT
    TGTTTTTAAA ACTGTTTTAT ATCTTAAGAG TGCCTTATTA
    AAGTATAGAT GTATGTCTTA AAATGTGGGT GATAGGAATT
    TTAAAGATTT ATATAATGCA TCAAAAGCCT TAGAATAAGA
    AAAGCTTTTT TTAAATTGCT TTATCTGTAT ATCTGAACTC
    TTGAAACTTA TAGCTAAAAC ACTAGGATTT ATCTGCAGTG
    TTCAGGGAGA TAATTCTGCC TTTAATTGTC TAAAACAAAA
    ACAAAACCAG CCAACCTATG TTACACGTGA GATTAAAACC
    AATTTTTTCC CCATTTTTTC TCCTTTTTTC TCTTGCTGCC
    CACATTGTGC CTTTATTTTA TGAGCCCCAG TTTTCTGGGC
    TTAGTTTAAA AAAAAAATCA AGTCTAAACA TTGCATTTAG
    AAAGCTTTTG TTCTTGGATA AAAAGTCATA CACTTTAAAA
    AAAAAAAAAA CTTTTTCCAG GAAAATATAT TGAAATCATG
    CTGCTGAGCC TCTATTTTCT TTCTTTGATG TTTTGATTCA
    GTATTCTTTT ATCATAAATT TTTAGCATTT AAAAATTCAC
    TGATGTACAT TAAGCCAATA AACTGCTTTA ATGAATAACA
    AACTATGTAG TGTGTCCCTA TTATAAATGC ATTGGAGAAG
    TATTTTTATG AGACTCTTTA CTCAGGTGCA TGGTTACAGC
    CCACAGGGAG GCATGGAGTG CCATGGAAGG ATTCGCCACT
    ACCCAGACCT TGTTTTTTGT TGTATTTTGG AAGACAGGTT
    TTTTAAAGAA ACATTTTCCT CAGATTAAAA GATGATGCTA
    TTACAACTAG CATTGCCTCA AAAACTGGGA CCAACCAAAG
    TGTGTCAACC CTGTTTCCTT AAAAGAGGCT ATGAATCCCA
    AAGGCCACAT CCAAGACAGG CAATAATGAG CAGAGTTTAC
    AGCTCCTTTA ATAAAATGTG TCAGTAATTT TAAGGTTTAT
    AGTTCCCTCA ACACAATTGC TAATGCAGAA TAGTGTAAAA
    TGCGCTTCAA GAATGTTGAT GATGATGATA TAGAATTGTG
    GCTTTAGTAG CACAGAGGAT GCCCCAACAA ACTCATGGCG
    TTGAAACCAC ACAGTTCTCA TTACTGTTAT TTATTAGCTG
    TAGCATTCTC TGTCTCCTCT CTCTCCTCCT TTGACCTTCT
    CCTCGACCAG CCATCATGAC ATTTACCATG AATTTACTTC
    CTCCCAAGAG TTTGGACTGC CCGTCAGATT GTTGCTGCAC
    ATAGTTGCCT TTGTATCTCT GTATGAAATA AAAGGTCATT
    TGTTCATGTT AAAAAAAAA
    LOC494127 NR_036691.1 GCAGTGCCCG ACTCCGCAGG AGCGCCAGGG CGGCTCCTGC 18
    TCTTCCTGGA CTCCCTGAAG AGGCGTTTGT CGAAATGTCC
    ACAGAAGGAG GATTTGGTGG TACTAGCCGC AGTGATGCCC
    AGCAAAGCCT AAAGTCCTTC TGGCTTCGGG TCATGGAAGA
    AATCTGGAAT TTAGCAGTGA AAGATTTCTG AATGCAGGAA
    CTCCCACTGG CTCGTATTAA GAAGATTATG AAACTGGATG
    AAGATGTGAA GATGATCAGT GCAGAGGCCC CTGTGCTCTT
    TGCCAGGGCA GCCCAGATTT TTTATCACAG AGTTGACTCT
    TCGAGCCTGG ATTCACACAG AGGATAACAA CTGCCGGACT
    TATGTCGCCA TGGCAATTAC GAAATTTGAT CAATTGGATT
    TTCTCATCGA TATTGTTCTA AGAGATGAAC TGAAACCTCC
    AAAGTGTCAG GAGGAGGTGC TGCAGTCTGT AACTCCTGCT
    GAGCCAGTCC AATACTATTT CACGCTGGCT CAGCAGCCCA
    CCGCCCGTCC AAGTCCAGGG ACAGCAGCAA GGCCAGACCA
    CCGCCAGCTC CATGACCACC ATGCAGCCTG GGCAGATCAT
    CATCGCACAG CTTCAGCAGG GCCAGACCAC GCCCGTGACG
    ACGCAGGTTG GAGAAGGTCA GCAGGTGCAG ATTGTCCAGG
    CCCAGCCACA GGGTCAAGCC CAGTAGGCCC AGAGTGGTAC
    TGGATGGACC GTGCAGGTGA TGTAGCAGAT CCTCACTAAC
    ACAGGAGAGA TCCAGCAGAT CCCGGTGCAG CTGAAGGCTG
    GCCAGCTGCA GTGTATCCGC TTAGCCCAGT CTGTATCAGG
    CACCCACGTT CTGCAGGGAC AGATCCAGAC ACTTGCCACC
    AGCGCTCAAC CGATTACACA GACAGAGGTC CAGCAAAGAC
    AGCAGTAGTT CAGCCAGTTC ACAGATGGAC AGCAGCTCTA
    CCAGATCCAG CAAGTATCCA TACCTGCGGG CCAGGACCTG
    CCCAGCCCAT GTTTTTCCAG TCAGTCAACC AGCCCTCTGA
    TGGGCAGGCC CCCCGGGTGA CTGGCGGCTG AGGGCCGGAG
    CTGGCAAGGC CGAGGACACT CAACACAATT TTTGCCGTAC
    AGCCCCAGGT CATGAACACA GCCTTCTTCC CCAGAGGACC
    CGGCCGACCT CAGCTCCTCC TGCAGGCTAG GACAATGGCG
    CACTAGGCCT CATGCCTGGG GGCCGAGATT CTCCAACAGA
    AAGATGCAAT ATTTTTTGTT TCCTTTTTTC TCCAAGGAAT
    CAATATTTCA ATATGTTGAG CTGTGTGTCC AATGCTATGA
    AATTAAAATA TTAAATCACA AAAAAAAAAA AAAA
    LOC646471 NR_024498.1 AATGAATCCA ACTACTGTCC TTGTCCTCTC CTCTCTAGGT 19
    TTGTGGAGAC TGAATTCCAC AAACCTAGGG ACAGGGCACT
    CTCTAGGGGC AAGTCAACTC TCAATTATAG TGAGGGCAGG
    TTCCCCAGTT GCCAGCCTAC ACCCTGGCCA GCCACCCAAG
    GGAATACCTG CTGCTGCTAA GGCAGTCAAT GTTGGGAGGG
    TCAGGGAAGG GGAGAGGAAG TAGCTGAGTG TAGAGATTAT
    CCAGGCTTTC CTTCCCGTCC TCTGTACAGA AAGGCAGACA
    TACACTGACT CCTGAAGTGC CCCAGGATCA TAGTTGGTTC
    TTCTTAGGGG GAGGGAGTGA AACGGTGGCC TTGCTCCAAT
    TCCAGGCCTC TGGAGAAAGG AGTGCTCAAC TGGAGAGTCT
    CAGAACCTTT TACAGTACTT CAGCAGGCCC AGCACCCAAC
    CTTCCCCACC ATACCCCTGC CCTGGGAATG CCCCTTACCA
    CAGTGGCTTC CATTCCTGAC ATTTGAACCA GCTCCTGCAC
    TTGAAGGACA AGGCAGCCAC TGGGCAGCTC CGGGAGGCGG
    GAGGCGTGAC TCCTTCATAT CAGGCCATCT GGAGGAGCAC
    CAGATTTCCC TCTTGTGAAA CAACCCCCCA CAGTGGGGAT
    TTAATGGTCA CCACACAAGC CCCAAAAAAC CAGGCCCTGC
    AGAGCCATGA CTTCACAGGG GAGAAAACCA GCCCAAGAGG
    CTGCCCTCAC CCAACACTTA GCTCTAAGTC CAGACTCTTA
    AAGGTTCTGT TAAAGATCTG CGGCCAGGCG CAGTGGCTCA
    CATCTGTAAT CCCAGCACTT TGGGAGGCCG AGGTGGGCGG
    ATCACGAGGT CAGGAGAGCG AGACCATCCT GGCTAACACA
    GTGAAGCCCT GTCTCTACTA AAAATACAAA AAATTAGCCA
    GGTGTGGTGG CGGGCACCTG TAGTACCAGC TACTTGGGAG
    GCTGAGGCAG GAGAATGGCG TGAACCCAGG AGGCAGAGCT
    TGCAGTGAGC CGAGATCACG CCACTGCACT CCAACCTGGG
    TGACAGAGCG AGACTCCGTC TCAAAAAAAA AAAAAAAAAA
    AAAAGATTTG CCTAGTGAGC TTGGCCAACC CAAGAGCCTT
    CCTGGGCTCT CAGGTTTCTT GAGGCAAAAC TTCTAAAGAT
    GCAAATAGAA TCCTTGGTAG CTACAAAGCT CATCTAGCCA
    AATTATAAGT ACTATCCAAG CCCAGGATTC ATTCTTGAAG
    ATGAGATGTA AAAGCACTGC TGGGCCCTTG CAAAGGGAGA
    GATCAGAGAA AATAGGAGAA CGAACACCAG CTCATGCCAA
    TCTCAGTCTC ATGAGCTACA GAGAAAAAGA GCCAAAAAAG
    TTTATCCTGG CTCAGCCACC TTCTGGCTTT GTAGCTACAG
    GCAAGTTATT TAACTTTTCT GAATGTTGGT TTTTCCATCT
    GGAAAAAGGA GACAGGAAAA GCTGCCACTG GAGGCTACCT
    TAAGGGTCAA TGAGTGAAAT GGGGTTGAGT GCTTAATGAA
    CTGTTAAAAC ATGACACAGA TGGGTGAGGT GACATCTGAC
    TGCTCTTCAC AGCAGTCCTT GCATGGTGAG CAGATGCAAT
    CAGTGTGCTC GTTCATTCAC TTGTTCATCA AACACCAACA
    GTACCCACTT GTGCCAGGCC TTGTGCTGGG CACCGTAGGG
    GCTATGGAAG GAGTAAGACA CAGTCATGCT CTCAAGGAAC
    TCGCTGTCCA GCAGAGTGAT AGGACATGAA TACATACTTC
    TAGCAAAGGC TGAGTAGCAT TAGGCAGGTG GCCAGATGAG
    GTCAGAGCTC TGGCCCTAGT GCCCTGTAGT AAGTTGCGAG
    GGAGTAGGAA ATGAAGACAA AACAGCAAGA GCACAGGTCC
    AGCACAAGAA GGTGAAGGAC ATGGAAAGAG GAGCAGAGCA
    TGATAAAGCT ACAAAAGTAG GGGGCAAGTC ATGAGGTCCG
    GGTCACTGGG GAGCCCTGGA CAGGCTCTGA ATGGGAGATA
    GACTAGACTG ACAAAGCAGC TCTTTCTGGA GACCTCCTGT
    GGAGGGTCCC CTCTTCTACC CTTGGGAGAC GAGGTGTCAT
    TCACTTCACG ATACACATGG GGAAAGGAAG TTGGACAGGG
    GAAGGCACTT GTCTAAGGTC ACTCAGTGGT CATGCCAGTG
    CAAAGCACCC AAAGCCTGGT CCAGGTCCTG CCACCTCCTG
    CGTGGGCTCC ATCTTCTCGG CTCAGTTCAA GCCTTTATTA
    TCAGAGTCCC TCTGTGTGCC AGGCTCTGTG CTGAATGTCC
    GTGTCGGCCA CAAATTGCAC TAACGGTGCT TACTGCCACT
    TCCTCTCCGA CCTTACCTCC AAAGACCCAG CCGGGCCTAA
    CCCTCACACA CAGCCAGAGG AATCCTTCCC AAACACAGTT
    AATCACATCG CTCATCCGTT TAAAACTGGC TTACTAGAGC
    CAACACAGGA TAAAATCCAC AATCAGTCCC AAACCCATCT
    TTCTCTGCCG TCTCTAGACC ACATTCACTG AGCACCAAGG
    CCTGCACGCT TCGCAGCCAG CCCTCCTGCT CTCCCCCTTG
    CCCTCCAGCC ACACTGGCCC TCAACCCCCA ACACTGGGCC
    CACCTCTGAG CCCTGCATCA AACACCAGCA CCCCCTTCGC
    CGAGCTCATT CTTCATCATT CCTCAGAGCT CAGCTTAAGC
    ATCACCTTCC TTCCCTGCGA CAGGGTCAGG TCCTTTCCTG
    TGCGCTCCGC AGCACCCTGC CTGTCCCTCG GAGTCCTCGC
    GAGAGGAACT AGATAACTGT GATCCCCGCG CACAGCACGG
    TGTCTGCCTA GGACACAGTG AGCGCTTCAA CGCGCTGAAC
    TAAACGAATG AAGGGGAACA CCAACTCAGC TGTCACCCCC
    GCCCCCAAGT GTCACTGGCT AGAAGATCTT CCCCCGGTTC
    GCCGGCAGCA CCGGTGGGTC TTGTCACCTC TGCGCCCCGC
    AGCCCTCCGG AGGCTGCAGT TGCTGTCTGC TGACAGGCGT
    CCCCTCAGGA GAACGGGAGC TCCTCCAGCG CAGGGCCCTG
    CTCAGCACCC CTGGTCCCGG GGGCCCCCAC GGAGGCCGCC
    GCGCTCAGTG AAACTTTGCC GCGCGCAGCA GTGGCCGGAG
    ACCCGCGCGG ACCCTCTCCC CGCGGGGACC CGCCAGGGCG
    AGTCGCCCCT CCCCCGCGGC AGACGACCCG ACCTGGGCCA
    AGGTCGGCCA AGTGCTCGCC GCCTGCCCAG CGGCCCTTGG
    ACCCACAGGA CCCGGACCCG AGTGCGCGGA AGCCTCCGAG
    CCGCGGCCAG GTCTCAGAAT GCGCGGCGGG GCAGCCCGGC
    CCGTCAAGCA GCGAAGCCGA AACTAGAAGC CTGAGGTCTG
    GCTTGGTCAC TGTTTGCTGG GGAACTCCGA CGAGCAACTA
    CCCTTCGGGG ACTCAGTTTC CCCCGGGCCA AGTGAGACGG
    ACAGCTGCGG CTCCCGCGAG AACTCGCGCG GGAACAGGAG
    CTGCGGGCTC CGCACAGCGC CCGGCACGTA GACCCAGTCT
    ACTAACGGGC TGGAAGGTCG CGCTCCCGCC TCCGCGCCTC
    CCTAGAACCT TTCTCACCTC AAGCTCGGGC TCCCGGACTC
    TCTCACCTCA CGGCCCCTCC TTCCACCTTG GGCCGCCCAG
    CCTCAACCGC CCT
    LOH12CR NR_024061.1 GGCTACGCAA GACCTTCAGT TCCGGATTAG GAGGCCCCGC 20
    CCCCCGGCCC GAGGGAGGGG CGGAGAGACC CGCTCCTGCG
    ACTTAGGGCG ATGCCACCTT AAAGGGCTTG ACCTCCTCGA
    AGCCAGAACT GCGGAAGAGG ATGGAGAAAG AAACGCTAGA
    TAGACCCAGG ATTCGAACCC ACAACAGCTT GGATGCAAAG
    CTCATTTTGA ATTCTGAAGA GCTGGGAGTT TAGCAGTGGA
    CGACCAAACA AAAAAATACC AGAAGACGGT GAAAGCAGCA
    GCTGGAAATG AGAGAAAAAT TAAGAAATAG AAAATGCTGT
    TTCATGTATT AGGGAGTGCA CATCTTTAAA GAGAAGTGAA
    GAACCTTTTT GGCTAGGCGC TTTCTGGGGA CCTTGGCAGT
    TATCAACAAG TCACTCTGAA ACTAACAGAA GGTGAGGAGG
    GAGTAATCCA GAAAGGAAAC TGCCATTTTT GCTAGGGCAA
    GAAAGTAGAC CTAGCAATGC AATGCCATCA AGGAGTTAGC
    TGGCTCTAGC GTTCTCCGAA CTTTGCAACT CATTTTATAT
    TACATTGTCT GCGTCAAGAA ATTTCAAGTA AATGCCTTGA
    GATTTTATAT GTATAAAATG TAGTCTCTGG CCAGGCGGGG
    TGGCTCACGC CTGTAATCCC AGCACTTTGG GAGGCTGAGG
    CGAGTAGATC ACGATGTCAG GAGATCAAGA CCATCCTGGC
    TAACATGGTG AAACCCCGTC TCTACTAAAA AATACAAAAA
    ATTAGCCGGG CATGATGGTG GGCGCCTGTA GTCCCAGCTA
    CTCGGGAGGC TGAGACAGGA GAATGGTGTG AACCCGGGAG
    GCAGAGCTTG CAGTGAGCCG AGATCGCGCC ACTGCACTCC
    AGCCTGGGCG ACAGAGCGAG ACTCCGTCTC AAAAAAAAAA
    AAAAAAAAAA AAGTCTCAGA AGAAGTGTCA AGTTGACTAA
    ATGATTTTTA AGTCCCTTCC ACTCTACTAT ATCACAATAA
    TTTCCCCTAT TTTACCTTAT TTAATTTTCA CAACAACCCT
    GCAGCCTGTA AGTAGGTGAC TCCTCCATGG TCAGCAGGTG
    GTCAGTGGTC GAACTATTTA GGACTATCTG ATGCTCTTTC
    CTCTGCTCAC CATTGCAATA CAATGAGAAA AATGCAAATG
    AATCTAAGTA CAGTGTTCTC TGGGAATATG AAGATAGAAC
    TAAAAACTGC CTGAGAGATC AGGGCAGGCT TCTAGAAAGT
    TGTGTCTAAC TAGTCTTGAG GTTTACATAA ACCACACCAG
    GCTGATGGGA CTGGGAAGGG CCCACTAAGC AGTGAGACCA
    TTCCCTTTTG GAGAGTCCTT GCATCCCCTC CCAGATTTCC
    TCTTTGAGGG GAAGGTGAGA GAGGAGGTAA AAGGGGTGAG
    GAATGGAGAA TAACTCATTC TGGTTCTTGT TTCCCCTTTT
    CCACATAAAA GTATATTTGT CTTGTGTTCC ATACACCAGT
    CCATACTGAT GTGATGGTGT TTTTTATGCT TCCTTTTGAA
    TAAACATTTC ATTCTTAA
    PBXIP1 NM_020524.3 GGTCAGTTTC TGGTCACATG ATTTTCTTCT CGGGCTGCAA 21
    ACAAAGGGAA GCCTGCAACA AGTTAAGCTG AAGACCGAAG
    CAAGAGCTGG TTCAGGTGGC AGCCACAGCA GCCTCAGGGA
    CCTCAGCAAC TATGGCCTCC TGCCCAGACT CTGATAATAG
    CTGGGTGCTT GCTGGCTCCG AGAGCCTGCC AGTGGAGACA
    CTGGGCCCGG CATCCAGGAT GGACCCAGAA TCTGAGAGAG
    CCCTGCAGGC CCCTCACAGC CCCTCCAAGA CAGATGGGAA
    AGAATTAGCT GGGACCATGG ATGGAGAAGG GACGCTCTTC
    CAGACTGAAA GCCCTCAGTC TGGCAGCATT CTAACAGAGG
    AGACTGAGGT CAAGGGCACC CTGGAAGGTG ATGTTTGTGG
    TGTGGAGCCT CCTGGCCCAG GAGACACAGT AGTCCAGGGA
    GACCTGCAGG AGACCACCGT GGTGACAGGC CTGGGACCAG
    ACACACAGGA CCTGGAAGGC CAGAGCCCTC CACAGAGCCT
    GCCTTCAACC CCCAAAGCAG CTTGGATCAG GGAGGAGGGC
    CGCTGCTCCA GCAGTGACGA TGACACCGAC GTGGACATGG
    AGGGTCTGCG GAGACGGCGG GGCCGGGAGG CCGGCCCACC
    TCAGCCCATG GTGCCCCTGG CTGTGGAGAA CCAGGCTGGG
    GGTGAGGGTG CAGGCGGGGA GCTGGGCATC TCCCTCAACA
    TGTGCCTCCT TGGGGCCCTG GTTCTGCTTG GCCTGGGGGT
    CCTCCTCTTC TCAGGTGGCC TCTCAGAGTC TGAGACTGGG
    CCCATGGAGG AAGTGGAGCG GCAGGTCCTC CCAGACCCCG
    AGGTGCTGGA AGCTGTGGGG GACAGGCAGG ATGGGCTAAG
    GGAACAGCTG CAGGCCCCAG TGCCTCCTGA CAGTGTCCCC
    AGCCTGCAAA ACATGGGTCT TCTGCTGGAC AAGCTGGCCA
    AGGAGAACCA GGACATCCGG CTGCTGCAGG CCCAGCTGCA
    GGCCCAAAAG GAAGAGCTTC AGAGCCTGAT GCACCAGCCC
    AAAGGGCTAG AGGAGGAGAA TGCCCAGCTC CGGGGGGCTC
    TGCAGCAGGG CGAAGCCTTC CAGCGGGCTC TGGAGTCAGA
    GCTGCAGCAG CTGCGGGCCC GGCTCCAGGG GCTGGAGGCC
    GACTGTGTCC GGGGCCCAGA TGGGGTGTGC CTCAGTGGGG
    GTAGAGGCCC ACAGGGTGAC AAGGCCATCA GGGAGCAAGG
    CCCCAGGGAG CAGGAGCCAG AACTCAGCTT CCTGAAGCAG
    AAGGAACAGC TGGAGGCTGA GGCACAGGCA TTAAGGCAAG
    AGTTAGAGAG GCAGCGACGG CTGCTGGGGT CTGTACAGCA
    GGATCTGGAG AGGAGCTTGC AGGATGCCAG CCGCGGGGAC
    CCAGCTCATG CTGGCTTGGC TGAGCTGGGC CACAGATTGG
    CCCAGAAACT GCAGGGCCTG GAGAACTGGG GCCAGGACCC
    TGGGGTCTCT GCCAATGCCT CAAAGGCCTG GCACCAGAAG
    TCCCACTTCC AGAATTCTAG GGAGTGGAGT GGAAAGGAAA
    AGTGGTGGGA TGGGCAGAGA GACCGGAAGG CTGAGCACTG
    GAAACATAAG AAGGAAGAAT CTGGCCGGGA AAGGAAGAAG
    AACTGGGGAG GTCAGGAGGA CAGGGAGCCA GCAGGAAGGT
    GGAAGGAGGG CAGGCCAAGG GTGGAGGAGT CGGGGAGCAA
    GAAGGAGGGC AAGCGACAGG GCCCGAAGGA ACCCCCAAGG
    AAAAGTGGTA GCTTCCACTC CTCTGGAGAA AAGCAGAAGC
    AACCTCGGTG GAGGGAAGGG ACTAAGGACA GCCATGACCC
    CCTGCCATCC TGGGCAGAGC TGTTGAGGCC CAAGTACCGG
    GCACCCCAGG GCTGCTCAGG TGTGGACGAG TGTGCCCGGC
    AGGAGGGCCT GACTTTCTTT GGCACAGAGC TAGCCCCAGT
    GCGGCAACAG GAGCTGGCCT CTCTGCTAAG AACATACTTG
    GCACGGCTGC CCTGGGCTGG GCAGCTGACC AAGGAGCTAC
    CCCTCTCACC TGCTTTCTTT GGTGAGGATG GCATCTTCCG
    TCATGACCGC CTCCGCTTCC GGGATTTTGT GGATGCCCTG
    GAGGACAGCT TGGAGGAGGT GGCTGTGCAA CAGACAGGTG
    ATGATGATGA AGTAGATGAC TTTGAGGACT TCATCTTCAG
    CCACTTCTTT GGAGACAAAG CACTGAAGAA GAGGTCAGGG
    AAGAAGGACA AGCACTCACA GAGCCCAAGA GCTGCGGGGC
    CCAGGGAGGG GCACAGCCAT AGCCACCACC ACCACCACCG
    GGGCTGACAC CCTGCCCCAC AGGGAATGGC CTTGGCCTGG
    CCCAGCCCAA GATCCCAGCG TTATCTAACT CCTGGAGGGT
    GGACTCTGTC CTGGCTTGTT TGGTGTCCTC AGATATCTTT
    CACACAGTAG AGCAAAATCA CCAGCCCTGC ACTGATGTCA
    CTTTATGTAG AAAAAGGCCT TAGCTGGACC TGCGTTGCCG
    TCTATGCAAA TGCATGCAAA TACTCCAGGC CCTGGGATGT
    GGGCTTGTGT TTTGTCACTG TGAAGGGGGA GATGGGAGAG
    GAGCCTGTTT TGGGGTGGGG TCTGGGGAAG GCAATCTGAT
    TCTGAAGCTA AAGAGCTTTC ATCCTCTTGA GTGTATGTCC
    CCATAGTGGG CCCCTTGACC CACATGCTGA CCGGTGCCTT
    GGGATTTGAC TAGAGTTGCT GGCTCGAGGC CCAGCACGAG
    GACTTACCCT GGGGTTTTGT TAGGTTTGGA AGCAGCTGTC
    CCTAGGGGGT GAAGTCCCCC CCCTTTTTTT TTTTACCCCT
    GCTTCTCCCA CGGCTTCACC TCCCTATGTG AACTGTAGAC
    TCAGATCCCA ATAAAGTGCT GTTGCAGCTA TGATGCTAGG
    TGGTTTCTAA GCACAGGGGA CACCCCACAC CCCCTGCCTG
    AATGGATGGG TCCATCCCAG GCACTGGTAC TTGCCCCCTT
    GTTCTGTATC CCCCTTTGCC CTTGCCTTGC CCTTCCAACA
    AACCCTAGGC CCTTGAGAAG CTGATACTTC TCCTTTTGCT
    CACAGCTGCC TTGGCCCCAC CCCTGGGAGA TGTAGCAAAT
    TGAGTGTGGG TTTTGGAGTC TGAGCCTCAG GCTCAAATCC
    AGGCCAAGTG ATCTTGGGCA AGTTAATCTC TGGGAACTTT
    GGGTTTCTTA TCCTCAAAAA AGGCGATGGA AGGGCTGGGG
    AAGTGATTAA ATAAAAGCAA CGCAAGAAAA AAAAAAAAAA
    AAAAA
    RNF5 NM_006913.3 AATAGTGATT AGGAAACCTT GAAGCCTGCC CAACGATCGT 22
    GGGCAGGAGG TGGTTTCTGG TTTGTTGGGG CGTGTGTATG
    TGTATTTGGG GGGACTGAAG GGTACGTGGG GCGAAACAAA
    ACCGGCCATG GCAGCAGCGG AGGAGGAGGA CGGGGGCCCC
    GAAGGGCCAA ATCGCGAGCG GGGCGGGGCG GGCGCGACCT
    TCGAATGTAA TATATGTTTG GAGACTGCTC GGGAAGCTGT
    GGTCAGTGTG TGTGGCCACC TGTACTGTTG GCCATGTCTT
    CATCAGTGGC TGGAGACACG GCCAGAACGG CAAGAGTGTC
    CAGTATGTAA AGCTGGGATC AGCAGAGAGA AGGTTGTCCC
    GCTTTATGGG CGAGGGAGCC AGAAGCCCCA GGATCCCAGA
    TTAAAAACTC CACCCCGCCC CCAGGGCCAG AGACCAGCTC
    CGGAGAGCAG AGGGGGATTC CAGCCATTTG GTGATACCGG
    GGGCTTCCAC TTCTCATTTG GTGTTGGTGC TTTTCCCTTT
    GGCTTTTTCA CCACCGTCTT CAATGCCCAT GAGCCTTTCC
    GCCGGGGTAC AGGTGTGGAT CTGGGACAGG GTCACCCAGC
    CTCCAGCTGG CAGGATTCCC TCTTCCTGTT TCTCGCCATC
    TTCTTCTTTT TTTGGCTGCT CAGTATTTGA GCTATGTCTG
    CTTCCTGCCC ACCTCCAGCC AGAGAAGAAT CAGTATTGAG
    GGTCCCTGCT GACCCTTCCG TACTCCTGGA CCCCCTTGAC
    CCCTCTATTT CTGTTGGCTA AGGCCAGCCC TGGACATTGT
    CCAGGAAGGC CTGGGGAGGA GGAGTGAAGT CTGTGCATAG
    ATGGGAGAGC CTTCTGCTCA GAGGCTCACT CAGTAACGTT
    GTTTAATTCT CTGCCCTGGG GAAGGAGGAT GGATTGAGAG
    AATGTCTTTC TCCTCTCCTA AGTCTTTGCT TTCCCTGATT
    TCTTGATTTG ATCTTCAAAG GTGGGCAAAG TTCCCTCTGA
    CTCTTCCCCC ACTCCCCATC TTACTGATTT AATTTAATTT
    TTCACTCCCC AGAGTCTAAT ATGGATTCTG ACTCTTAAGT
    GCTTCCGCCC CCTCACTACC TCCTTTAATA CAAATTCAAT
    AAAAAAGGTG AAATATAAAA AAAAAAAAAA AAAAAAAAAA
    AAAAAAAAAA AAAAAA
    SERTAD2 NM_014755.2 CTCCTGCACG GCGAGTGCTG GAGCACGACG TACCGCTCGC 23
    TCGGTCAGGG CGCCCCCTCC GCCCGCCTCC TGCTTCCTCC
    TCCGCTGCCT GCCGCCGCCG CCTCCACCAT TGTATAATGC
    TCGGGGCGCG CAGGCAGAGA ACGGCGGAGT CTTAGCTTCA
    GCCTCGCCTG CTGCCCGCTC CCCGGCGCCA CCCTCGGGCC
    CCTGGAGCGG GGCACTCCGC ATGGAGCGGG AGTAGCTGAG
    GAGTGGGCGG AAACCCCTCC TGATGCGTTA GTTCCCAGGT
    GGAGCTGCAT GTGATATATG TTGGGTAAAG GAGGAAAACG
    GAAGTTTGAT GAGCATGAAG ATGGGCTGGA AGGCAAAATC
    GTGTCTCCCT GTGACGGTCC ATCCAAGGTG TCTTACACCT
    TACAGCGCCA GACTATCTTC AACATTTCCC TTATGAAACT
    CTATAACCAC AGGCCCCTGA CAGAGCCCAG CTTGCAAAAG
    ACCGTTTTAA TTAACAACAT GTTGAGGCGG ATCCAGGAGG
    AACTCAAACA GGAAGGCAGC CTGAGGCCCA TGTTCACCCC
    CTCCTCCCAG CCCACCACCG AGCCCAGCGA CAGCTACCGA
    GAGGCCCCGC CGGCCTTCAG CCACCTGGCG TCCCCGTCCT
    CCCACCCCTG CGACCTCGGA AGCACTACGC CCCTGGAGGC
    CTGCCTCACC CCGGCCTCAC TGCTCGAGGA CGACGATGAC
    ACGTTTTGCA CCTCCCAGGC CATGCAGCCC ACGGCTCCCA
    CCAAACTGTC ACCTCCAGCC CTCTTGCCAG AAAAGGACAG
    TTTCTCCTCT GCCTTGGACG AGATCGAGGA GCTCTGTCCC
    ACATCTACCT CCACAGAGGC GGCCACGGCT GCGACTGACA
    GTGTGAAAGG GACCTCCAGC GAGGCTGGCA CCCAGAAACT
    CGACGGTCCT CAAGAGAGCC GCGCAGATGA CTCAAAACTG
    ATGGACTCTC TGCCTGGGAA TTTTGAAATA ACGACGTCCA
    CGGGTTTCCT GACAGACTTG ACCCTGGATG ACATCCTGTT
    TGCTGACATT GATACGTCCA TGTATGATTT TGACCCCTGC
    ACTTCCTCAT CAGGGACAGC CTCAAAAATG GCCCCTGTGT
    CTGCCGACGA CCTCCTCAAA ACTCTGGCTC CTTACAGCAG
    TCAGCCTGTC ACCCCAAGTC AGCCTTTCAA AATGGACCTC
    ACAGAGCTGG ACCACATCAT GGAGGTGCTT GTTGGGTCCT
    AAGACCCAGG GACCCAGCGA CTATGCCCAC CCAGACCCCA
    GAGCGTTCCC ATAACCCTGA CAGTTCTCCA CACTGTGCAT
    GCACCCTTGC TTGCCTTTTT CAGAGAAAAA GAAAATTTTA
    CAACAGGATC ACACTAGTTT TTGCTTTGAG CAGAGTTGGA
    GTGCCTTCAT CCAAGTATGA CCACTTTTAA TACACTTTTT
    TGAGTGGTTC CTCAGAGACC TACTACCCTG GTATAGGAAA
    GAATCCATTT GAAGACAATG TTGCAATGTT GAATGACAAA
    AATAAACAGT TCAAGTGAAG CACAAGGATT AAGTTGGAAA
    AGCTGTAAAT TGCATGTGCA TATTTGTCTA TTTTTTCTAT
    AAGTTTTATT GCAAGAGGTA AAGAAGAAAA CTATATATAT
    ATATCTTATT TAGATAATCT CAGTACCTTT TCTGGCATTT
    TTGCCCTGTA TAGGTTGACT TGGCAATTCG GCCTTTTTAG
    AGGCATTAAC TACTCCTCGT AAGTGTTGCA TTTACATGGC
    TGTTTAGAAA ACTGCTGCCC AAATTTATTT TATATTTTTG
    TACAGATTCT GCAGTTTATG ATATTGTTTT TCTAAAAACA
    AATGCTGTTT ATACATATGA GATAGCTATT TTGATAGGAT
    TTGCTCACAT AGTTCCTGCA AACTTCAGAT GTACAAGTTG
    CACTTGTACT TTTATAGAGT TGTAATGTTT TATATGTGTA
    TGGTGCAAGA GAAAATTGGA TCAAATCAAT CTGCAGTTGA
    TGTCCCCAAA TGCAAACACA GGCACACACA TGCACACACC
    CATAAACACA CACACAGTGC TTTAAGAAAG GGCCAGGTGA
    TATCACACCC AAATTTCACA AGCACTGACC CCCTGGCACC
    AACACCCGCC AGTACTGTGA CTTCCAAAGC CAGAGCCACA
    TGTGCTCATC AAACTTGCAT TAAGCAGTTG GCGGGAGATG
    GCTGTGGAGC TGGGGGTTTA AGTGATGGTT CTCTTTTGCT
    CCCTCTTTTG AGGGTAAAGC TACTGTCTTT CTTAAGAGTG
    TATTTATGCC AAGTTTGCGC TTTTAATTGT TTTTATTTTG
    TTTTTTAATG AAAACCCAGA TCTTTCCTTT TTGGCATAAT
    TTTTATGATG ACCTGAAATT TTACATCCGA ACAAAATTTT
    ACATCCGAAA AGCAACCAAC TTCTTCATGG AACTCAGCCC
    TGTTGCAATG CTTAGGGCCC TTAAAGAAGA AAATCTCCCC
    AGAAGGCATC CATCATGTTG CTTAATTGTC TTCTGCAGCT
    TCCTTTCCCT AGAGCTTTCC CTGTGTTGCT AAGAGCTGAA
    AATGGCATCT TCGTGATCAC CACAGTGAGC TTGGCTCGCC
    TCGGCCGGCC CGGGATGCAC TCTTACAACA TGTGTGACTC
    TTGAACCTGG AGTTCATCAC ATTACGTCAC AGCTTCCCAT
    CTGGTTGCTT TCCTGAGTCA GCTACTTCAC ACTTGTCAAG
    GCTGTTTTAC CCCAAAACTC AGACAGGACT TTCTATGCAT
    GTTTTCCCTC CTCCCCCCAA TTCCCCCCCC CATCACCTTA
    TCTCCCAGGA CACACTTGAG AAGTAGCTTT TTATTCCTAG
    TGGTGTACAT TTAATTTTAA AAAGGTTGCA ATGTATCATG
    CTTGTTGCCG AAACTGTTTA TGGCCTTCTT GTTTCAGTTT
    TTTCTTTTCT TCCAATGGTA CTTTAGCTGT TGAGTGCAGG
    TTACAACCTA TATTGTTATG CAGATGGCTT CTTTAGGAAT
    AACTTTTATA TTTATTTAAA AATTTTTAAA TTATGGGATG
    TTTTGTTGTT GTTGTTGTCT TTGTTGTTGG TCATTTGTCA
    ATATTCAGTC ACCAATTCTG CTCACTTCTT GCCATGGATA
    AAATTGGGTC TTTCTGGCTA ATTAAAAAAG ACAACTTTAT
    AAAATGGCAC TTTAAGCAAG CCATAGTTAG TTTTATTTTT
    GTAATGCACA TGGCAAAGCA AAGACGTTTG TGATGAAGGA
    ACTGCTCATC TAAGCAAAAG ATTTGAGTAT GATATGATAA
    AGGCTTTCTA CATTCTAATT TACTTTTTCC CCCCACTTGA
    ATGTGTTTTA AAGGCTAATT ATCAGCTCAG TAGAGCAGTG
    AGAAACTGAT CAAATTGCAC TTGTTCTCCT ACAAGCAACC
    TCCACGCAGA CACCTCGTAC TGCTACAGGT GTGTCATTTC
    CTTTAATAGG ACCAGGGACC ATGTAACTGA GGTGAGGGTT
    GTAGTAGATG CTTCCAGTGT CAGTATGCCT GTTAATTTTA
    AGAGCTTCCC TTTCTTGCAG AGAACAAGTC TGCCCAGATT
    CCATGCTTTC TATAACTGGA GGACCTGGCA AACCTGCCGC
    ATGCTGCACA CATCTACCTA CGTACACATA TACAATAGTA
    TTGATGATTC TGAACAATAA CAGGGTAAAA CAGTTGGTTT
    GCCATTGTTA AAAACTGATT TACAGTAACT TACAACAACT
    GTACTTTTGT TGGATTAGCA AATCATGTGT TTAAACAAAT
    CCCATATGTT GGGCAACAGT TCAAATAAGC ACGGAGAAGT
    GTTGCCCAAA CTTGGTTCTC TGACTCTTAT GTATTTGTAA
    GGCTGGGCTT CAAAATCAAA ACAAAAACCC CAAAAACAGC
    AGGCAAATGC TTTTTAACTC TGACACCGTT GCCATAAATC
    CCTGATACTC AAAGTCTAAC AAGAAAGACA TGGAAAATTA
    GCAGCCCATT TTCAGAAAGA TCAAAATGAT CTAGGGTTCT
    AATTGCTTTT GCATCCTATT CTTACAAAGT GATGTCCCAA
    CAGGGAACAG TAGGAGCTGG AGTGGGATCT CCAAGTCCCA
    GTTTGAGTGT GGGATGTGCT TCCAGCAGTG CCTTCCCTTT
    ATGAAAGACA TCACATGGCA TCCAGGGCCA GGCAGGCAGC
    TTGAGGTGCC TTTACGAGAA AACCGAGCTG GGGCTGGGAG
    AGGACAGTTA TTGACACTGA TGTGCAATGA AGTGACAAGA
    TGAGAGCAGA ATCGTAAGAG CTTTGAATTT GAAGTGAGTT
    TTTTTCCCCC CATAAGTTAT TTATTCCTTT TTTCTGTGTA
    AATATATTTA TTTTACTGTG GAGCGCTAAC ATCTGGATCG
    TAACATGTGC AGAATGTATG GTAGGAATGT ATTCTCTTGT
    AGGAATGTAA ATCTGTATTA AAAGGGGGTC CAAGCCAGGC
    CCCCAGGTCT TCTCATTGTA TGCACAGTCC GCATTCATTT
    TTACTCTTCT CTAATATGGG TCTATTTGAA ATATGCAAAA
    GGTATGAGGA ATGTTTTAAT ACCTCCAAAT TTTTAAGAAA
    AGCATCAAAG GGTTGATATT TTTTAAAGTT TTTTTAGTAG
    CACTTTCTCT GGATGACAGA AGGAGCAACC ACATGGGCAC
    CCTTGTTCAT ACCAAAGGGT GAGCAGTGGC CAGAGCCTCC
    TCTGCACCTC TCGAGTGTCT TTACCAATTG AGCTTTTTAT
    CGCCATAGCC CCTTGGAGTG CCCCAGCTGC CCTGAGGTCA
    ATCAAGGAAA ATTTCTTAAT GAAATAAGCT CCAAAGAGCC
    AAAGTATCAA CTTACAGATC GTTTTTAAAG CTTAAATTTA
    TGAACCACCT TTGTGGTAAA CAATGAATTA TGAATACCGC
    AGGGCAGCCT TCTTAAATGA CAAATGTAAA AAAAAAAAAA
    AAAAAGACTC TACTTCGTGC AGCAATTGCT ACTCTATACG
    AATTGTCTTA ATTTGAAAAC CTTGCTGTTA CAAATTGGAC
    CTTTATACAT TTTCTGAAAA CAATGAAAAG AGTATATTTA
    ACCTTTTCTG GCTGTAAATG GTTACCTTCC TGTAACTGCC
    CCGCACCTGG AGGCATGGAG TTGTGTGCAT CCTGCTTATG
    TACAATTGTT TTCAGTGTTT CTAAGAATGA GTCTGAATGG
    TTCTTGAAAA TTAGCCAGGA TCAAATGCTA TTGCAGACAA
    AGCCAATAAA AAGTTGGACT TCTTTTGGGG ATAACAAGTT
    TTGGAAGAGA AATGCAGGCC ATATGTGCGC ATGACCGAGA
    TTTTGAAAAA AGATGTACAT AGTGACATGT TTGGTGCATG
    GTTTTTGAGG AGGGCTTTTG TCAAAAAGGA GGTATAACCT
    TTCCCCCACA GACCTGAGAG CTGTGCCTTT TCTATGCAAT
    ATTACAGACG TTACATCGGA ACCCAGATGG CTGTATTCAC
    ATGTAGGTTT GGGCTGTAAT CTAAACAATT GGACAGATTA
    AATGTACATG GAAATGAGCA GTCTTACTTT TGTAGTTTTA
    TATTATACAA TAAACAGTTA AAAGATGAAA AAAAAAAAAA
    AAAAA
    SLC35G5 NM_054028.1 TACCACCTCA GGAGAGTTCC AGGGAAGAAC CCCACCCGCA 24
    CTCCAATGAG GTCACAATGG CTGGAGCTCT GAGGGGCCCA
    GGCTCCCTGA GCCAGGAGGA GAGGAGAAAG TCCAAGGAAA
    GATGGCTGGC AGTCACCCCT ACTTCAACCT GCCTGACTCC
    ACACACCCAT CGCCGCCCTC CGCTCCACCC AGCCTCCGCT
    GGCACCAGCG CTGCCAGCCC TCTGGTGCCA CCAATGGCCT
    GCTGGTGGCC CTGCTGGGTG GGGGCCTGCC TGCTGGCTTC
    GTGGGCCCCC TTTCTCGTAT GGCTTACCAG GGTTCCAACC
    TGCCCTCGCT GGAGCTGCTC ATCTGTCGAT GCCTCTTCCA
    CCTCCCTATT GCCCTGCTAC TTAAACTGCG TGGCGACCCC
    CTTCTGGGAC CTCCTGACAT CCGAGGCTGG GCCTGCTTCT
    GTGCCCTGCT CAACGTCCTC AGCATTGGAT GTGCCTACAG
    TGCAGTTCAG GTGGTGCCCG CTGGCAACGC TGCCACTGTT
    CGCAAAGGTT CTTCCACCGT ATGCTCCGCT GTCCTCACCC
    TCTGCCTTGA GAGCCAGGGT CTCGGTGGCT ACGAGTGGTG
    TGGACTGTTG GGCAGCATCC TAGGACTAAT CATCATTCTG
    GGACCTGGAC TCTGGACACT ACAGGAGGGG ACCACAGGTG
    TCTACACCAC CCTGGGCTAT GTGCAGGCTT TCCTGGGAGG
    CCTGGCGCTG TCCCTGGGGC TTCTGGTCTA TCGTTCTCTG
    CACTTTCCCT CCTGCCTCCC AACAGTGGCC TTCCTATCTG
    GCTTGGTGGG GCTGCTGGGC TGTGTGCCAG GCCTCTTTGT
    GCTGCAGACC CCCGTGTTGC CCAGTGACCT CCTGAGTTGG
    AGTTGTGTGG GGGCAGAGGG GATCCTCGCC TTGGTCTCCT
    TCACATGTGT GGGCTATGCG GTCACCAAGG CCCACCCTGC
    CCTGGTGTGC GCTGTCCTGC ATTCCGAGGT GGTTGTGGCC
    CTTATACTGC AGTATTATAT GCTCCATGAG ACTGTGGCAC
    TTTCTGACAT CATGGGGGCA GGGGTTGTGC TGGGCAGCAT
    TGCCATCATT ACAGCCCGGA ACCTCAGCTG TGAGAGGACA
    GGGAAGGTGG AGGAGTGAGA TAGAACTTGG GAGCCCGGGG
    GTTGGGAGGG ACAGGGATAA ATAAAGACAA AGACTGAAGA C
    SPATS2L NM_001100422.1 AGTGCTGAGG GAGCAAAGTT CATTTTCTCG GGTAGGAGAA 25
    GATGATTCTC TTGCAACACG TGCGGATTGT GACAAAATCT
    TTCATTAACA AGGGGAGTTT CGGTGAAGTG GAGGTTTGGG
    GAAAGGCGAG GAAGTCGGTC TGGAGCAAGC AAGCAAAGTG
    CGGAAGCTGT ACTGGGATTC TTCTAGAAAG TGGGGTGGGA
    AAGGAGCTAG GGAGGGCGTG TGGAGGGACG AGATCTGTGT
    CAGAACGTGC GTGTGAGCGG ATACAAAACC CGAGAGAGGC
    GTGAGCAGCG CTGTGTTTGC GAGCGGGAGC GAGGGGCGCC
    GGCTGGGGTG TGTGCTCCTG AGCTCTTCAG AAACCAGGCT
    GCTTTCAGGA ACATTGCTGT GGATTCCCAG GGCCTATTCC
    ACTAGAAGCA AGATGGCTGA ACTCAATACT CATGTGAATG
    TCAAGGAAAA GATCTATGCA GTTAGATCAG TTGTTCCCAA
    CAAAAGCAAT AATGAAATAG TCCTGGTGCT CCAACAGTTT
    GATTTTAATG TGGATAAAGC CGTGCAAGCC TTTGTGGATG
    GCAGTGCAAT TCAAGTTCTA AAAGAATGGA ATATGACAGG
    AAAAAAGAAG AACAATAAAA GAAAAAGAAG CAAGTCCAAG
    CAGCATCAAG GCAACAAAGA TGCTAAAGAC AAGGTGGAGA
    GGCCTGAGGC AGGGCCCCTG CAGCCGCAGC CACCACAGAT
    TCAAAACGGC CCCATGAATG GCTGCGAGAA GGACAGCTCG
    TCCACAGATT CTGCTAACGA AAAACCAGCC CTTATCCCTC
    GTGAGAAAAA GATCTCGATA CTTGAGGAAC CTTCAAAGGC
    ACTTCGTGGG GTCACAGAAG GCAACAGACT ACTGCAACAG
    AAACTATCCT TAGATGGGAA CCCCAAACCT ATACATGGAA
    CAACAGAGAG GTCAGATGGC CTACAGTGGT CAGCTGAGCA
    GCCTTGTAAC CCAAGCAAGC CTAAGGCAAA AACATCTCCT
    GTTAAGTCCA ATACCCCTGC AGCTCATCTT GAAATAAAGC
    CAGATGAGTT GGCAAAGAAA AGAGGCCCAA ATATTGAGAA
    ATCAGTGAAG GATTTGCAAC GCTGCACCGT TTCTCTAACT
    AGATATCGCG TCATGATTAA GGAAGAAGTG GATAGTTCCG
    TGAAGAAGAT CAAAGCTGCC TTTGCTGAAT TACACAACTG
    CATCATTGAC AAAGAAGTTT CATTAATGGC AGAAATGGAT
    AAAGTTAAAG AAGAAGCCAT GGAAATCCTG ACTGCTCGTC
    AGAAGAAAGC AGAAGAACTA AAGAGACTCA CTGACCTTGC
    CAGTCAGATG GCAGAGATGC AGCTGGCCGA ACTCAGGGCA
    GAAATTAAGC ACTTTGTCAG CGAGCGTAAA TATGACGAGG
    AGCTCGGGAA AGCTGCCCGG TTTTCCTGTG ACATCGAACA
    GCTGAAGGCC CAAATCATGC TCTGCGGAGA AATTACACAT
    CCAAAGAACA ACTATTCCTC AAGAACTCCC TGCAGCTCCC
    TGCTGCCTCT GCTGAATGCG CACGCAGCAA CCTCTGGGAA
    ACAGAGTAAC TTTTCCCGAA AATCATCCAC TCACAATAAG
    CCCTCTGAAG GCAAAGCGGC AAACCCCAAA ATGGTGAGCA
    GTCTCCCCAG CACCGCCGAC CCCTCTCACC AGACCATGCC
    GGCCAACAAG CAGAATGGAT CTTCTAACCA AAGACGGAGA
    TTTAATCCAC AGTATCATAA CAACAGGCTA AATGGGCCTG
    CCAAGTCGCA GGGCAGTGGG AATGAAGCCG AGCCACTGGG
    AAAGGGCAAC AGCCGCCACG AACACAGAAG ACAGCCGCAC
    AACGGCTTCC GGCCCAAAAA CAAAGGCGGT GCCAAAAATC
    AAGAGGCTTC CTTGGGGATG AAGACCCCCG AGGCCCCGGC
    CCATTCTGAA AAGCCCCGGC GAAGGCAGCA CGCTGCAGAC
    ACCTCGGAGG CCAGGCCCTT CCGGGGTAGT GTCGGTAGGG
    TTTCACAGTG CAATCTCTGC CCCACGAGAA TAGAAGTTTC
    CACAGATGCA GCAGTTCTCT CAGTCCCGGC TGTGACGTTG
    GTGGCCTGAG CTAGGAGGAA AAAGAGCAGT TTTCACTCAG
    TTTTGGTTCC CTGCCCGAGG TGCTGACCCA ATTCGCTGCC
    AAAAGAGTGT CAATCAGAAT ATACAAATCC CGTATGGTTG
    TGTCATCCTC TCTTAATCAT TTTTACTAAT TCTAATAATC
    AGCTCTAGCT TGCTTCATAA TTTTCATGGC TTTGCTTGAT
    CTGTTGATGC TTTCTCTCAT CAAGACTTTG CAGCATTTTA
    GCCAGGCAGT ATTTACTCAT TATTAGGAAA ATCAAGATGT
    GGCTGAAGAT CAGAGGCTCA GTTAGCAACC TGTGTTGTAG
    CAGTGATGTC AGTCCATTGA TTGTCTTTAG AGAGTTAATG
    TTACAAAAAA GAATTCTTAA TAATCAGACA AACATGATCT
    GCTGAGGACA CATGCGCTTT TGTAGAATTT AACATCTGGT
    GTTTTTCTGA AAAAATATAT ATACATATAT TGCTTTATTT
    GAAACAAATT AAAATATGCT GCATTTGACA CCTGGCTAGT
    TTCTTTTATT GATACCCACC TAGTTATTGA ATGTACTGTT
    TAGTGCTTTC AAAAAAAACT TTAGAGACTA GAGGTTGTGG
    TGCAAAGCTG TGTACAATAA ATACTGTTTC TGTTGAGACA
    AGTACTCTTT CAGGAAAATA TATATATGCC CTTTCAATTA
    GATTACACAA ATAGATGGAT ATGCACCCTG ATCATCTTAG
    ACACACCATG TGGCAGTTGG GCAGTTGGAA ACATTGGTTG
    CAAGTACTAC AAACCTCAGC TGAGCCTAGC TTCAACAATA
    AGAATTTATT GGTTCAGTGA GTGAAAAGTC CAGTTGGTCC
    AATTTGATCA GGATTTCAGC TCCCATCTCT TTTTTTTTTT
    TCTTTTTTCT TTTTCTTTTT TTGAGACAGT CTTGCTTTGT
    CACCCAGGTG GAGTGCAATG GCATGATCTC GGCTCACTGC
    AACCTCCGCC TCCTGGGTTC AAGCCATTCT CCTGCCCGGC
    CTTCCGAGTA GCTGGGATTA CAGGCATGTG CCACCACGCC
    CTGCTAATTT TTATATTATT AGTACAGACA GGATTTCACC
    ATGTTGTCCA GGCTGGTCTC AAACCCCTGA CCTCAGGTGA
    TCCACCTGCT TTGGCCTCCG AAACTGCCGG AATTACAGGC
    ATGAGCCACC GTACCCGGCC AGCTCCCATC TCTTAATTAT
    CTTAGCTCTC CTTTCCTCCT TGGGTTGACA TTGCATTCAG
    AATTGTGGCA AAGGGCCACC ATGCTCTTAA GACTCAAGTC
    TATTTTCCAC ACTGTCCAGA GGAGAGAAGT TATCCTAGTA
    GCTTCTACAC AGAGCAAGTG TCTTTCTCAG AAATCCCAGC
    AAAGGTCTTG CATACCATTG CTGGTAGGCC TGTCTCTTAA
    ACCAATCATG AAAGGGGGGA GAGAAGTGAA TGGGATGAAC
    TAATTTGCAT AGACTAATTA GAGCCCACCC CTGGAGCCTG
    GGTGTGGCCA TCTTCCCAGA GTTCCTGAGC TAGATGGAGA
    AGGGGTACTT CTCAGAAAGG GAAAATGGAT ACCCAATGGC
    CCAAACCCAA AATAGCCCCA GTTCCCCTAA CTTTGACTAC
    AGGGCAGTCC AGTTTGGGTG CCGCTTCCGT TGCACTCACA
    TGTCCTACAT ATCTGTTGAC TACTCACAAG TGCAAATGCT
    TATTCTCAAC TCAACATTAA CATTTTTTCT GGCAACCCAG
    GTTCACTGGT TCTCTTCCAC AGAGCGGCCC TGAGCAGCTG
    AGCCTGCAAG CCACGCAAGC ATCTGTTTCT TCTTTTGCCA
    AGTACAGGAG GATGTTTGCT CTCTCTGTAG AGAGCTTTCT
    GAGGTCTCTG GGTGTACCCA GAGATTTAAT AGAAATTCTT
    AACGTTAAGT CACATTCCAG GAAGGAAGGA AGAGTTGTTC
    GTTCAAATAA GAAAGATAAA TGTTCGGCAC TGTAGGCCCT
    GTTTACCCCA TCTGAGGCCC TGAATTCATA TATTACAAGA
    CGGAAGGATT TTGCACAGTT TTTTATGTAG CAAGATTTTG
    CTCACCACTG AAAAATGTCA GTGTAAATGT GACCGCTTTA
    AAGATGAGTC AAGTAATTCT TGGAACAGGG AAAAAAATGA
    ATTTGCCAGG TCAGGAGTTC ACCTGCCTTT GTCAGAGTTG
    AACCCAACCA CTCTTGACCT CGACTCACTC CCTTAGGGTT
    AAGAAAGCCC AAACACATTC CTGAGCACAG AGCAAACACT
    CCCATGTCAC TGAAAAGAAA CAAAAGAATG CTAAAAAGTG
    CTCAGACCTG ATCACATTTT TTCCAATATT TTTTCCTTTT
    TTTTTTTTTT TTTGAGACAG GGTCTTGCTC TATCACCTAG
    GCTGGAGTGC ATGTTTTTGA GACAGGGTCT TGCTCTATCA
    CCTAGGCTGG AGTGCATGAT CATGGCTCAC TATAGCCTTG
    AACTCCTGGG CTCAAGCCAT CCTCAGCCTC CCAAGTTGCG
    AGGACTACAG GTGTGCACCA CAACGTCCCA GCTACTTTTT
    AAATTTTTAG TAGAAACGAG GTCTCACTAT GGTGCCCAGA
    CTGGTCTCGA ACTCCGGAGC TCAAGTGATC TTCCTGCTTT
    GGCCTCCCAA AGTGTTAGAA TTACAGGCAT GAGCCACCTC
    GCCTGGCTGG TTTTTGCCTT TCTTATAGAC CCTGGGCATG
    TAAGCATTTA TTAGTTTGCA TTTTTGAAAC AGTAATTTCA
    ATATTTTAGT GCCAATGTCA GGCCGCTTAA ACACTGTATT
    ACATATCTTC ATCTGTCTGG TGGAACTATT GGTGTGATCC
    TAGAGAACTG AGTCCTATTC TGCCATTCAT TTAAAGTGTT
    TTAAACTCTA ATCTCTCTAC TTAATGCACA GTAGTCAGAT
    TATTCTCTTA AACATTTGCC TAGTAGAGGT TAAAATAGTT
    TAATCCTTAT GAAGATGGAA TAACTTCAAA CTCACATTGT
    GGCACTTAGA TCTTCCACCA AGACTTCATC CGTGAAATCC
    ACACCTCCCT GTTGGGTTCC CAATTACATT CCAAATTTAC
    ATTTCTTTTG AGAATCTCTG CATACTCCAG CTCTGTCCTG
    TTGATCCTAT TCTAGAAGTG CTTAATGCAG CAAGACACAG
    AAAGTTAAAC GCAAATTGCT GCAAAATTCA CCCTCAGTGG
    AGGACTAGAA ACACAACATG TCCAATTTAA AGCTCAGTTC
    ACAAGCAGTT CAATTCTGCT GGCATCAGAA AAGGAGATTC
    TAATTAAACA TTCTTAGGGA AGGACATCAA ATGAGGTTAA
    TGGGAAACGT TACCAGATTA AAAGCAGTTT TTTGACAAAG
    TAACAGATTT GGAAATTCTG ACTCTCTGAA AGCCTTGATT
    TGAACCTCAA ACTTGATTTC ACCATGAGAA GTGGGGATCA
    AGGGCCTGCG CAGTTCTTTT CCTAAATCGA TTCGGTGCTC
    CCCACCCCGA CGCAGGCACA GGTCCGCAAC CAGATAGGGA
    GATGCCTGAA TTTCAGGCTA CCTTTGACAA AGCTTTCTTC
    CTCCCTCCCT CCCTTTGCAC GCTGCATCCC ACGCTGCCTG
    CTTAAAGCGC CCTCATGTGT CTACAGATGG TAAAACGTTT
    ATTTCTCAAC AGACATTCCA GTGATAGCAT CCAATGACCT
    ATGTAACGGC ACCCTTTTTT GCTGTACGCG TTTTTTGAGA
    TGGAGTCTCG CTCTGTCGCC CAGGCTGGAG TGCAGTGGCG
    CGGTCTCGGC TCACTGCAAG CTCCGCCTCC CGGGTTCACG
    CCATTCTCCT GCCTCAGCCT CCCGAGTAGC TGGGACTACA
    GGCACCCGCC ACCACACCTG GCTAATTTTT TGTATTTTTA
    GTAGATACAG GGTTTCACCG TGTTAGCCAG GATGGTTTTG
    ATCTCCTGAC CTCGTGATCC ACCCCCCTCG GCCTCCCAAA
    GTGCTGGGAT TACAGGGGTG AGCCACTGCG CCCGGCCCCA
    GTCACTTGTT CTTAAGTTTC TTAAGCAAAC TATAAAATAG
    CAAAAGACCA AAAAAAAAGG AAAAAAAGCA GTTCGCCTAA
    TACATTGTTC CAGCATTTCC TTGAAAGTAC TGAGCCATCT
    CAATTGCTCT GATTTTGTGA GAAAATTATG AAGAGTTGCA
    AAGTCCCAGT GATTCTCTTG TTACTTAGCT AAGAATTTGA
    AATGTAATTT AAATACTATT CTTTACAATC CATTATAAGG
    ATTTTAAAAT CTTTTTGCTT CTTTAATAAA TTCTAACAAA
    GAAAAAAAAA AAAAA
    TDRD7 NM_001302884.1 AGAGCCGAGG CCAGGCTGCC CTCGAAGCGG GGCGGGGCGA 26
    AGCGGGGCGG GGCCGAGCAG GGCGGGGCGG GGGCTTGAGG
    TGATTCCCAA GCCGCGGGGC GGCTCCGGTG GTGCGGGGAA
    ACCGAAAGTG GGCGGCGGCC GCGGCGGGGC CCCTGGCGGA
    GACGGCGGCA GGAGCTGGGC CCAGAGACGC GGGGACGGGC
    CGTGGGCCCC CGGAACGAGA TTACCTGCTA TGCCATGGCC
    TGCACAGAAA CTGCAAGAAT TGCTCAGCTT GTGGCTCGTC
    AAAGGAGTTC TAAAAGGAAA ACCGGGCGTC AAGTTAATTG
    TCAGATGAGA GTGAAGAAAA CCATGCCATT TTTTCTAGAA
    GGAAAACCAA AAGCAACCCT CAGACAACCA GGATTTGCTT
    CAAATTTTTC TGTTGGCAAA AAACCTAATC CAGCACCGTT
    AAGAGACAAA GGAAACTCTG TTGGAGTTAA GCCTGATGCT
    GAAATGTCTC CTTATATGCT ACACACAACT CTTGGAAATG
    AAGCATTCAA AGACATTCCA GTGCAAAGGC ATGTGACCAT
    GTCCACCAAC AACAGGTTTA GCCCAAAGGC GTCCCTTCAA
    CCACCTTTGC AGATGCATCT CTCAAGAACC TCTACTAAGG
    AAATGAGTGA TAATTTAAAT CAGACTGTTG AAAAACCCAA
    TGTCAAGCCT CCTGCCTCTT ACACTTATAA AATGGATGAG
    GTTCAAAATC GCATAAAGGA AATACTAAAC AAGCATAACA
    ATGGCATTTG GATATCTAAG CTTCCACATT TTTACAAAGA
    GTTATATAAA GAAGACCTTA ATCAAGGAAT TTTACAACAG
    TTTGAACACT GGCCTCATAT TTGCACGGTG GAGAAACCTT
    GCAGTGGTGG CCAAGATTTA CTTCTTTATC CAGCTAAGAG
    AAAGCAGCTT TTGAGAAGTG AACTGGATAC TGAGAAAGTA
    CCTCTATCCC CACTACCTGG TCCCAAACAA ACACCACCGT
    TGAAAGGGTG TCCAACAGTT ATGGCAGGAG ACTTTAAAGA
    AAAAGTGGCA GACCTGCTGG TGAAATACAC AAGTGGCCTT
    TGGGCCAGTG CACTTCCGAA AGCATTTGAG GAAATGTACA
    AAGTGAAATT CCCTGAGGAT GCCTTAAAAA ATCTTGCCTC
    ACTTTCTGAT GTATGCAGCA TAGACTACAT TTCTGGAAAT
    CCCCAGAAGG CCATTCTCTA TGCTAAACTT CCATTGCCCA
    CTGACAAAAT CCAAAAGGAT GCAGGGCAAG CACATGGTGA
    TAATGATATC AAGGCTATGG TTGAACAAGA GTATTTGCAG
    GTAGAAGAAA GCATTGCTGA AAGTGCTAAT ACCTTTATGG
    AGGACATAAC AGTTCCTCCT TTAATGATTC CAACTGAAGC
    ATCACCATCT GTATTGGTGG TTGAACTGAG CAACACAAAT
    GAAGTGGTTA TCAGGTATGT GGGCAAAGAC TATTCTGCTG
    CTCAGGAATT AATGGAAGAT GAGATGAAGG AATATTACAG
    TAAGAATCCT AAGATCACAC CAGTCCAGGC TGTGAATGTT
    GGGCAGTTGC TGGCCGTAAA TGCCGAGGAG GACGCCTGGT
    TACGGGCACA GGTCATCTCA ACAGAAGAGA ACAAAATAAA
    GGTATGCTAT GTTGACTATG GTTTTAGTGA AAATGTTGAA
    AAAAGCAAAG CATACAAATT AAACCCGAAG TTTTGTTCAC
    TCTCATTTCA AGCTACAAAA TGTAAGCTTG CAGGCTTGGA
    AGTCCTAAGC GATGACCCTG ATCTAGTGAA GGTGGTTGAA
    TCTTTAACTT GTGGAAAGAT CTTTGCAGTG GAAATACTTG
    ACAAAGCTGA CATTCCACTT GTTGTTCTGT ACGATACCTC
    AGGAGAAGAT GATATCAATA TCAATGCCAC CTGCTTGAAG
    GCTATATGTG ACAAGTCACT AGAGGTTCAC CTGCAGGTTG
    ACGCCATGTA CACAAATGTC AAAGTAACTA ATATTTGCTC
    TGATGGGACA CTCTACTGCC AGGTGCCTTG TAAGGGTCTG
    AACAAGCTCA GTGACCTTCT ACGTAAGATA GAGGACTACT
    TCCATTGCAA GCACATGACC TCTGAGTGCT TTGTTTCATT
    ACCCTTCTGT GGGAAAATCT GCCTCTTCCA TTGCAAAGGA
    AAATGGTTAC GAGTAGAGAT CACAAATGTT CACAGCAGCC
    GGGCTCTTGA TGTTCAGTTC CTGGACTCTG GCACTGTGAC
    ATCTGTAAAA GTGTCAGAGC TCAGGGAAAT TCCACCTCGG
    TTTCTACAAG AAATGATTGC AATACCACCT CAGGCCATTA
    AGTGCTGTTT AGCAGATCTT CCACAATCTA TTGGCATGTG
    GACACCAGAT GCAGTGCTGT GGTTAAGAGA TTCTGTTTTG
    AATTGCTCGG ACTGTAGCAT TAAGGTTACA AAAGTGGATG
    AAACCAGAGG GATCGCACAT GTTTATTTAT TTACCCCTAA
    GAACTTCCCT GACCCTCATC GCAGTATTAA TCGCCAGATT
    ACAAATGCAG ACTTGTGGAA GCATCAGAAG GATGTGTTTT
    TGAGTGCCAT ATCCAGTGGA GCTGACTCTC CCAACAGCAA
    AAATGGCAAC ATGCCCATGT CGGGCAACAC TGGAGAGAAT
    TTCAGAAAGA ACCTCACAGA TGTCATCAAA AAGTCCATGG
    TGGACCATAC GAGCGCTTTC TCCACAGAGG AACTGCCACC
    TCCTGTCCAC TTATCAAAGC CAGGGGAACA CATGGATGTG
    TATGTGCCTG TGGCCTGTCA CCCAGGCTAC TTCGTCATCC
    AGCCTTGGCA GGAGATACAT AAGTTGGAAG TTCTGATGGA
    AGAGATGATT CTATATTACA GCGTGTCTGA AGAGCGCCAC
    ATAGCAGTGG AGAAAGACCA AGTGTATGCT GCAAAAGTGG
    AAAATAAGTG GCACAGGGTG CTTTTAAAAG GAATCCTGAC
    CAATGGACTG GTATCTGTGT ATGAGCTGGA TTATGGCAAA
    CACGAATTAG TCAACATAAG AAAAGTACAG CCCCTAGTGG
    ACATGTTCCG AAAGCTGCCC TTCCAAGCAG TCACAGCTCA
    ACTTGCAGGA GTGAAGTGCA ACCAGTGGTC TGAGGAGGCT
    TCTATGGTGT TTCGAAATCA TGTGGAGAAG AAACCTCTGG
    TGGCACTGGT GCAGACAGTC ATTGAAAATG CTAACCCTTG
    GGACCGGAAA GTAGTGGTCT ACTTAGTGGA CACATCGTTG
    CCAGACACCG ATACCTGGAT TCATGATTTT ATGTCAGAGT
    ATCTGATAGA GCTTTCAAAA GTTAATTAAT GACTGCCTCT
    GAAACCTTGA CAACTAATTC AGATTTTTTA GCAATAACAA
    AATGTAGTAG GCTTAAAAAA AATCTTAACT CTGCTACATG
    GCTCTGACTG CTGTGGGGGA TTGAAAAGAA TATGCTTATG
    TTTGATGAAA GATATTTAAC AAGTTTTGTT TTAACAGAGT
    TGACTTTTCA AAGAAAATTG TACTTGAATT ATTACTATAA
    TATTAGAATA AAAATGTTTA TCAATATAAA AAAAAAAAAA
    AAAAAAAAAA AA
    TOX4 NM_001303523.1 AGCAGAGAGA ACACACGTCC TTGCGGAAGT GACGGCAGTT 27
    (house- CCGAGTCCAG TGGGGGCGGT GGGAGCGATG AGGGTCTGAG
    keeping ACGGTGGGAG CGGTTGTGTG AAGATGGAGA CATTCCATAC
    gene) ACCAAGCTTG GGTGATGAGG AATTTGAAAT CCCACCTATC
    TCCTTGGATT CTGATCCCTC ATTGGCTGTC TCAGATGTGG
    TTGGCCACTT TGATGACCTG GCAGACCCTT CCTCTTCACA
    GGATGGCAGT TTTTCAGCCC AGTATGGGGT CCAGACATTG
    GACATGCCTG TGGGCATGAC CCATGGCTTG ATGGAGCAGG
    GCGGGGGGCT CCTGAGTGGG GGCTTGACCA TGGACTTGGA
    CCACTCTATA GGAACTCAGT ATAGTGCCAA CCCACCTGTT
    ACAATTGATG TACCAATGAC AGACATGACA TCTGGCTTGA
    TGGGGCATAG CCAGTTGACC ACCATTGATC AGTCAGAACT
    GAGTTCCCAG CTGGGTTTGA GCCTAGGGGG TGGCACCATC
    CTGCCACCTG CCCAGTCACC TGAAGATCGT CTTTCAACCA
    CCCCTTCACC TACTAGTTCA CTTCACGAGG ATGGTGTTGA
    GGATTTCCGG AGGCAACTTC CCAGCCAGAA GACAGTCGTG
    GTGGAAGCAG GGAAAAAGCA GAAGGCCCCA AAGAAGAGAA
    AAAAGAAAGA TCCTAATGAA CCTCAGAAAC CAGTTTCAGC
    ATATGCTTTA TTCTTTCGTG ATACACAGGC TGCCATCAAG
    GGACAGAATC CTAATGCCAC TTTTGGTGAG GTTTCAAAAA
    TTGTGGCCTC CATGTGGGAT AGTCTTGGAG AGGAGCAAAA
    ACAGGTATAT AAGAGGAAAA CTGAGGCTGC CAAGAAAGAG
    TATCTGAAGG CACTGGCTGC TTACAAAGAC AACCAGGAGT
    GTCAGGCCAC TGTGGAAACA GTGGAATTGG ATCCAGCACC
    ACCATCACAA ACTCCTTCTC CACCTCCTAT GGCTACTGTT
    GACCCAGCAT CTCCAGCACC AGCTTCAATA GAGCCCCCTG
    CCCTGTCCCC ATCCATTGTT GTTAACTCCA CCCTTTCATC
    CTATGTGGCA AACCAGGCAT CTTCTGGAGC TGGGGGTCAG
    CCCAATATCA CCAAGTTGAT TATTACCAAA CAAATGTTGC
    CCTCTTCTAT TACTATGTCT CAAGGAGGGA TGGTTACTGT
    TATCCCAGCC ACAGTGGTGA CCTCCCGGGG GCTCCAACTA
    GGCCAAACCA GTACAGCTAC TATCCAGCCC AGTCAACAAG
    CCCAGATTGT CACTCGGTCA GTGTTGCAGG CAGCAGCAGC
    TGCTGCTGCT GCTGCTTCTA TGCAACTGCC TCCACCCCGA
    CTACAGCCCC CTCCATTACA ACAGATGCCA CAGCCCCCGA
    CTCAGCAGCA AGTTACCATT CTGCAGCAGC CTCCTCCACT
    CCAGGCCATG CAACAGCCTC CACCTCAGAA AGTTCGAATC
    AATTTACAGC AACAGCCTCC TCCTCTGCAG ATCAAGAGTG
    TGCCTCTACC CACTTTGAAA ATGCAGACTA CCTTAGTCCC
    ACCAACTGTG GAAAGTAGTC CTGAGCGGCC TATGAACAAC
    AGCCCTGAGG CCCATACAGT GGAGGCACCT TCTCCTGAGA
    CTATCTGTGA GATGATCACA GATGTAGTTC CTGAGGTTGA
    GTCTCCTTCT CAGATGGATG TTGAATTGGT GAGTGGGTCT
    CCTGTGGCAC TCTCACCCCA GCCTCGATGT GTGAGGTCTG
    GTTGTGAGAA CCCTCCCATT GTGAGTAAGG ACTGGGACAA
    TGAATACTGC AGCAATGAGT GTGTGGTGAA GCACTGCAGG
    GATGTATTCT TGGCCTGGGT AGCCTCTAGA AATTCAAACA
    CAGTGGTGTT TGTGAAATAG TCCTTCCTGT TCTCCAAGCC
    AGTGAAGAGT TATCTGCTGG GAAAGTGTCC AAGAGCCTGT
    TTTTGAAACA CAAGCTGGGC TTCTGGTAGT GCCTCATCAC
    AACCCATGAT GGCTGTTCAT GTTTCACCCC TTTTCTTCCT
    TCAGCAGAGG CCAGGCTATG GAGCAGGGCC ACTGAATTTG
    CTGTAATCTG GAGATGCTTT TTACTTTCAA CCATAAGCGG
    TAATAGCAGA GGAAAGGGTG AAGGGAGTCT GGGCAAGCAA
    AGCATAGAGA TGGTGGGGTG GTGGTGGGGT TGAAGAAACT
    TGTTGGTATA ATTGTCATAG GACTTGCCTA AAATATTATT
    AAAATTACGG GAGTGTACTC AGCTTTGAGC CTAGGAGAAA
    ATGCCACTGT GTGCATCCAT TTTAAAGGGT TCCCTCATAA
    AAAAATGTTA TTCCCCATTA TCACATCAGT ACACTGCTTT
    GAAAACAAAA CTTTTCAACA TGGGCATACT GGGCTACATG
    GAAAATGACA TCACCCAGGA GTGATTTCTC TTTATATATA
    TTATTTCTGC AGTTACCATC CTTATCTGAG TTATCACAGT
    TCATGAATCT AAGAGGCGGA ACTCTACATC ATTAGTAAGA
    GGTTCCACCA AAGTCTAAAG TTGTATTCAC TTGTGTTTGA
    TGAACTATCT TTAAAAGACC ATAGGTCTAT CATTATTTCT
    TAGACATAAT CTAAAGAAAA ACAGACTAGA GAAGCCACCT
    GGTTGTAACA GAATAAGCAG AAGTTTACAG CATGATAGTC
    CAAGTGGTGA TAACTTTAAA TAAAACTCAA ATTTTTACTG
    TTTGTAGACA GGAATGCTGT CCTAGAGAAC CTCCTCCTCA
    ACCAGCTACG TACATAGTTT TATCCTATGC ATTCCTGTTT
    TCTGTGTGTT TTTTGTTTTT TTTTTTTTTT TTTTTTTTTG
    AGACAGAGTC TCGCTCTGTC ACCCAGGCTG GAGTGCAGTG
    GTGCGACCTC AGCTCACTGA AACCTCTGCC TCCCGGGTTC
    AAGCGATTCT CCTGCATCAG CCTCCCGAGT AGCTAGGATT
    ACAGGCGCCC GCCACTACGC CCAGCTAATT TGTGGTATTT
    TTAGTAGAGA CAGGGTTTCA CCATGTTGGC CAGGCTGGTC
    TCGAACTCCT GACCTCATGA TCCGCCCGCC TTGACCTCCC
    AAAGTGCTGG GATTACAGGC ATGAGCCACC GCACCCAGCC
    TGCATTCCTG TTTTTTTAAT GGTTTTGGAG GGTAGCAGTA
    GAGATGGGGT CTCACTATGT TGCCCAGTCT AGTCTTGAAC
    TCCTGGGCTA CAGTTACCCT CCTACCTCGG CTTCCCAAAG
    TGCTCGGATT ACAGGTGTGA GCCACTGTGC CTAGCCTATA
    ATGATCATTT TAATGTTTCC CATGCACTCA TTTAGTTTGA
    ACCTTCACAG CAACCCAATG AGGTAATACT CCCATTTCAC
    ATATAATACT GAGAGATGAG TTGCACAAGA TTATACACTG
    TTAAGTAGCA GAGCCAGAAT GGACTTCAGA ATCCCAACTA
    CAATACAAAT GTTTATTTAA ATAAAGAAGA AAGCTATTGT
    ACAAATATCA CTCTTCAGGT TTAGCTTACA GAGCCATGGC
    TATGGATTCT TAGCTCTGTA AGGAAGTGCT TCTATAAATT
    CTTAGGTTTA GAGATGATAC CATCTGGGTA CCTTTGCTTG
    AACCGTGCAA CCACATCTGG GTCTAGTAGG TGGATCCCAT
    CCAGTTGGTT TCCAAGGGTG ATCCTGAAAC AGTGTAAAAG
    GAGGGGCAAA CCAGAAATCC TGGAATTAGA GGGTTTAATA
    TTGTTAAAAA ATGCATACCA AATGAAGACT GCCTATCATC
    ATATCAAATA TGCCAATTCT AAAAAGAGCT TAACATTAGA
    ATAGTATATG GTAGAATTAC TAGTTCAGAA TTGGCATAGA
    TTCTGGTGTT AAAATAGACT GGATCTGTAT TATCTGAGGG
    TTAGTAACTA ATGCTTAGCC AGGCCTGCTT CACAGAGTTG
    CTACCAGGGA GTATTCTTTG GATAAGCAAA ATGCTAGCAG
    CATGTGTTTT AAGCTCTGTT AAGGGGTGAA AGATGTAATT
    ATTGACAGAT TAAATAGATA ACTTCGTAAC CACCAGGGGG
    CAGATTCAAT ACATCACAGA ATGGCTGAGG AAGATCCTTG
    GGTTGTGAAG AGAGTAGAAA CCCTAGGGAG CAGTGCTTTT
    GGGTCCTAGA ACCTGTTGAG TTTCTAATGA ATATTTGTAG
    AATCTCATAA AACAGTTTAA ATACAAGCTT AAGTGGCTTA
    TGAATCCTGT GAAGCTCATT TATGGACTAG TGTAAAACAA
    TGTGAAGCTC TACTAAGTTC TGTCCTTAAT CATAAATAAT
    AGCCCCTTGA GGACTAGCCT GTTCTCTGGT CACCTTACCA
    GTTGGGTTGC ACATTGTGTG GTCGTCCAAA TAACTCAATC
    TTGCGAGTGC CAGGAGATAG TCTTTCAATC ATGCCATAGA
    TTTCATCTGG TTTATGACTG GTGGAACGAA CCTAGGAAAT
    AAAAACTAGC TGCTTTTTAA GTTACACAAG AAAAAA
    TPT1 NM_001286272.1 CTTCGTGCCA CGTCACCGCC TGCGTCGCTT CCGGAGGCGC 28
    (house- AGCGGGCGAT GACGTAGAGG GACGTGCCCT CTATATGAGG
    keeping TTGGGGAGCG GCTGAGTCGG CCTTTTCCGC CCGCTCCCCC
    gene) CTCCCCCCGA GCGCCGCTCC GGCTGCACCG CGCTCGCTCC
    GAGTTTCAGG CTCGTGCTAA GCTAGCGCCG TCGTCGTCTC
    CCTTCAGTCG CCATCATGAT TATCTACCGG GACCTCATCA
    GCCACGATGA GATGTTCTCC GACATCTACA AGATCCGGGA
    GATCGCGGAC GGGTTGTGCC TGGAGGTGGA GGGGAAGATG
    GTCAGTAGGA CAGAAGGTAA CATTGATGAC TCGCTCATTG
    GTGGAAATGC CTCCGCTGAA GGCCCCGAGG GCGAAGGTAC
    CGAAAGCACA GTAATCACTG GTGTCGATAT TGTCATGAAC
    CATCACCTGC AGGAAACAAG TTTCACAAAA GAAGCCTACA
    AGAAGTACAT CAAAGATTAC ATGAAATCAA TCAAAGGGAA
    ACTTGAAGAA CAGAGACCAG AAAGAGTAAA ACCTTTTATG
    ACAGGGGCTG CAGAACAAAT CAAGCACATC CTTGCTAATT
    TCAAAAACTA CCAGTTCTTT ATTGGTGAAA ACATGAATCC
    AGATGGCATG GTTGCTCTAT TGGACTACCG TGAGGATGGT
    GTGACCCCAT ATATGATTTT CTTTAAGGAT GGTTTAGAAA
    TGGAAAAATG TGATGCAAAA GAAAGAAATC CCTGCGCTTT
    CTGTCTGTCT TTGTGGCGGC CCAGATTGAA TTGGGGAATA
    CATCTTTAGC CTGGAAATGT AGGCTGCATG TTAATGGTAA
    TGTAACTTTT GCAGTGTAAT GTTTGAAAAA TATTAATGTA
    GTTTTTGCTT TTACAGTAAC AAATGTGGCA ATTATTTTGG
    ATCTATCACC TGTCATCATA ACTGGCTTCT GCTTGTCATC
    CACACAACAC CAGGACTTAA GACAAATGGG ACTGATGTCA
    TCTTGAGCTC TTCATTTATT TTGACTGTGA TTTATTTGGA
    GTGGAGGCAT TGTTTTTAAG AAAAACATGT CATGTAGGTT
    GTCTAAAAAT AAAATGCATT TAAACTCATT TGAGAGAATG
    CCTTTTAGTT TAATGCATAT TTAAACTAAA TTGATCCTGT
    AGTGTTCCTG GAGAAGCTAG AGCCTGATTG TAGGCTACTA
    CTCATCAATT AACTTCTACA GTGGAGACTA CTTCTGGGAC
    TGGAATATAA AAAAGAATCA AAGGTTCTGA TTTTGAGTTG
    CAATAAAGGG AAAGACCATG CTCATAGCAG TGCCAACATC
    TGAAGTGTGG AGCCTTACCC ATTTCATCAC CTACAACGGA
    AGTAGTTAAC TGGAAGAGAT TACCAAGAGA ATAAAAAGAG
    ACTCATTCAG TGGAAGCAAC TTTGTCTCAG CTTATTTCAC
    ATAAAGAGAG CGAAGTCTTT TGGGATGAAT GTTAATTAAA
    CTCCCTGGTA ACTAGAACAG GGACTGGCAA ACTAGCCTAT
    CTGACCACCT GTTTTGTACA CTTTAAGGTG GTTGGTTGCC
    TTTTTAAATG GTTGAGGGGA AAAGAATACC TTGTGGGATA
    TGGAATTTAA GTTCGAGTCC AGTTTTATTG GAACGTGGCT
    ATGCTTATTC ATTTATGGAT TGACTGTGGC TGTTGTCAGT
    GCATGAGCAG AGTTGTGTCT AACAGACTAG AGCCTGCAAG
    TTTGCCAGCC CCTGATTTAA AAGATGAAGG TACACAGAAT
    GTGGGCTGGC TGGTGGGCAA AGGGGTAAAA ATGTTCTCTA
    TATTGTATCT GAAAAGATGG GGTGTCTGAA TAAGAAAATG
    CATCTATTTG ACAGACCTGG AGCAGTTGCT ATCTGCTGCT
    ATGGTTTCCA CCACAGATGC AAGAAGAACA TGTCCTTGCG
    CTTTCCGTCT GTCTAATTGT GGCAGCTGAG ATTGAATAGA
    GGAATACAGG AGGAAAAAAA GCGGGAAGAG TTTTTGAGGC
    AGGTCGGTCA CCCAGGCTTG TAGTGCAGTG GCACAAGCAA
    CTCACTGCAT TCTCTGCATC CTGTGCTCAA GCCATTTTCC
    CACCTCAGTC TCACTAGTTG CTGGGACTGC AGGCATGCAC
    CCCTATGCCC AGCTAATTTT TGTAGAGACC GAGTATCGCT
    TAGTTGCCCA GGGTGGTCTC AACTCCTGGG CTCAAGGAGA
    TCTGCCCACC TCAGCCTCCC AAAGTGCAGG CCTAGCCTGG
    GAGGGGAATT TTCAAAACGT GAGTTTTGGG AAATAGTCTA
    TCAGCCTTAC CTGGTTGATT ACACTTGTAA AAGAAAGATT
    AAAAGCAGGC CAGTGACTCT GGTCTGCTTG AACATGTGAA
    TGTAGTGGTT TGAGCAATCT GGAGTTTGCC CTAGTGTCAA
    ATTCCAGACT GTCCATAGTG TCCAAAACCT GAGGCAGATA
    CTAATGTTAA CCCCCAGCAC CCCGTGATTG GAAACAAACC
    TAAATACGTA TTGGGAACTT AATAGCAATT TTAAGCATTC
    TGATAGATTT TTTGTAGGGA TGGGGTCATG CCATGTGGCC
    CAGGCTGGTC TGAAAACTCT GGCCTCAAGT GATCTCAAGC
    TTTGGCCTTC TAAAGTGTTG GGATTACAGG TGTGAGGCAT
    TGCACCTGGC TTAGCGTTCT GATTTGACAT TGTAATGAAA
    AGTGTGAGTC TCATCTACAG GGCCTTTTGT CCTCTGAAAT
    GATAGCAGGA AGGGAATTTT CAGGCAGTGG TCAAAGCTGG
    GGAAACCAGG ATAGTGAAGA AGGCCTTGAG GTGAGAGATG
    GAAGCTAATT GGTGAACTAG CCTTGGAAGC CTGAAACAGA
    CAAGTAGCAA TTCAGAGACT TTGTGGGCTC CACTGCTCCA
    ACTTGTTTTG AAGATTTTCA GTTCTGCAGA AGAGGTATTT
    CCCCAGTTGT CCTTTCAGTG CTCTTAGCTG TTTTCCCAAC
    ATCCAGATCC AATCAAGGCT GGGACATAGC ATTTTATCAT
    GTCTATTTAA GTCAGAAGTG ATGAACCCCA GCTGTTTACC
    TCATGGTAAA CCTTTGAAGA TTCCAGGTAG AATCTTCTCA
    GACTTTGAAG ACTGTCTCAT TTTATATCTT TTTCTCGTTA
    TTCCTAGGGT CAAGACGTTT TGGGCAAGAA TAAGGATGTG
    AACATCAGAA AGCTCATAAC ATTTTGTTTT TGATGCTAAG
    TTTAACAAAG GCATGCTTTA GTAGCCTGTG GGCCCTAGGG
    TTTGTTAAAG TGTGGAGAAC AACTGAGTGG AGCAAGAGGA
    CTTTTCTAGG AAGGTCCTTG TAATGTGACA TTTGAAAACA
    AATGAAGGTG TGGAAGTAGG CCATGTGGAT ATCAGGACAA
    ACCATTCCAG GCCAAGACAA CAGCAGTTAG TCTGGAGTGT
    GATGTGTTCT GGGAAAAAAG TGGCCACTTT GCTAACCCAA
    GAAGACAGGA AGGGTTGTAA AGCAGTGGGA GTGTGCAAGG
    AAGGAAGACC AGACCTCAAG GAAACCACAG GCGCTCTGAG
    CAGAAGAGTT ACATGATATG ACTCAAATTT TTAAAGGATC
    ACTTTGGCTG CCAGGTGGCA GGGTAAAAGC ATAGAATAAT
    TGTGTATAAT GTGTTTTTAA GGCAAAGATA GTGGCTTAGT
    CTAGGGTAGT AGACTGAGGT GGTAGGAAAT GAAGATAGAG
    ACAACAGGAT ATGCTGGTGG GTGAGGATGG ATTTAATGTT
    GATACAAGTA TTTTGGTCTG AGCGTTTGGA AGAAAGTTGG
    CACTGAGGTG GGAAGTCGAG TTTAGTTTTG TTAGTTTTGG
    ATGTGTTAAG TTTGAGATGC TGATTCTTCA GAGAAGTCTA
    AGCTGGAGAA CTATATAGAG AGTGGAAAGA TAACAATAGA
    CATTGAAAGC CATGATACAG GATAAGGTCA TTTGGAGAGA
    GGATAGACTG CATTCCAACA TGAGATTGGT TGACAAAGAG
    AAACCAACAA AGGTAATTAA GAGGTGCTCC CACTGCACTT
    GTACTCAGAA GGCTGAGGTA GGATTGTTAG AGGCCAGCCT
    GGGCACCACA GGGAGACCCC ATCTCTAAAA TTTAGCCAGG
    AACCATGGCT CATGCCTGTA GCCCCAGGAA TTTGGGAGGC
    TGAGTGGGGA GGATCGCTTG AGGTCAGGAG TTTGAGACCA
    GCCTGGGCAA CATAGGGAGA CCTAAAAAAA TTAATTGGGC
    ATCTGTAGTC CCAGCTACTC AGGCGGCTGA GCTGAGAGGA
    TGGCTTGAGT CCGAGAGATT GAGGGTGCAG TGAGCTGTGA
    TCATACCACT GCACTCCAGC CTGGGCGGCA GTGAGACACT
    ATCTGAAAAA AGTTTAAAAA TTTTAAAAAA GAAGGAACTG
    CCCCTGAGGT AAGAACCAAG GGAGGGCCTC CCAGAGGTCA
    GGTGGAAAAA GTTTTAGGAA GGAGGAAGTA GTCAACAGGG
    TTACCTGTTG CAAAGTACTT AAGTAATATG AGGCCTGATA
    GTGGTAAACT TGACTACCGT TGGATTTCAC TAGTGGGAAA
    GGAAGTCTAA TTAAAATGCA CTCAAGAGAC TAACAGTCGC
    AGGCATGAAA TACAATACAG GTACATGGTT TTTTATTATG
    TGTGCATCTG CTTCAGTAAT AGGTGTGAAT TACTCATTTG
    GATCATTAGG AGTTTCAAAA TCTAGTTAAA TGACTAGATT
    TTTGTTGATG TAAATTCTGT CATTCTGAAC TGCAGGGATT
    GTCAGTAACT TAACTGCAAA CTAAACTGGT GATAATTATG
    GTAAAATTGC AAGACGAGCA ATAAATCTCA ACCAACTTGA
    GAGAACACTG ATAA
    TXK NM_003328.2 GATTTCAGTT GAAAGATGTG TTTTTGTGAG TAGAGCACCG 29
    CAGAAGAACT GAAGACTGTT GTGTGCTCCC CGCAGAAGGG
    GCTACCATGA TCCTTTCCTC CTATAACACC ATCCAGTCGG
    TTTTCTGTTG CTGCTGTTGC TGTTCAGTGC AGAAGCGACA
    AATGAGAACA CAGATAAGCC TGAGCACAGA TGAAGAGCTT
    CCAGAAAAAT ACACCCAGCG TCGCAGGCCG TGGCTCAGCC
    AATTGTCAAA TAAGAAGCAA TCCAACACGG GCCGTGTGCA
    GCCGTCAAAA CGAAAGCCAC TGCCTCCCCT CCCACCCTCT
    GAGGTTGCTG AAGAGAAGAT CCAAGTCAAG GCACTTTATG
    ATTTTCTGCC CAGAGAACCC TGTAATTTAG CCTTAAGGAG
    AGCAGAAGAA TACCTGATAC TGGAGAAATA CAATCCTCAC
    TGGTGGAAGG CAAGAGACCG TTTGGGGAAT GAAGGCTTAA
    TCCCAAGCAA CTATGTGACT GAAAACAAAA TAACTAATTT
    AGAAATATAT GAGTGGTACC ATAGAAACAT TACCAGAAAT
    CAGGCAGAAC ATCTATTGAG ACAAGAGTCT AAAGAAGGTG
    CATTTATTGT CAGAGATTCA AGACATTTAG GATCCTACAC
    AATTTCCGTA TTTATGGGAG CTAGAAGAAG TACGGAGGCT
    GCCATAAAAC ATTATCAGAT AAAAAAGAAT GACTCAGGAC
    AGTGGTATGT GGCTGAAAGA CACGCCTTTC AATCAATCCC
    TGAGTTAATC TGGTATCACC AGCACAATGC AGCCGGTCTC
    ATGACTCGTC TCCGATATCC AGTTGGGCTG ATGGGCAGTT
    GTTTACCAGC CACAGCTGGG TTTAGCTACG AAAAGTGGGA
    GATAGATCCA TCTGAGTTGG CTTTTATAAA GGAGATTGGA
    AGCGGTCAGT TTGGAGTGGT CCATTTAGGT GAATGGCGGT
    CACATATCCA GGTAGCTATC AAGGCCATCA ATGAAGGCTC
    CATGTCTGAA GAGGATTTCA TTGAAGAGGC CAAAGTGATG
    ATGAAATTAT CTCATTCAAA GCTAGTGCAA CTTTATGGAG
    TCTGTATACA GCGGAAGCCC CTTTACATTG TGACAGAGTT
    CATGGAAAAT GGCTGCCTGC TTAACTATCT CAGGGAGAAT
    AAAGGAAAGC TTAGGAAGGA AATGCTACTG AGTGTATGCC
    AGGATATATG TGAAGGAATG GAATATCTGG AGAGGAATGG
    CTATATTCAT AGGGATTTGG CGGCAAGGAA TTGTTTGGTC
    AGTTCAACAT GCATAGTAAA AATTTCAGAC TTTGGAATGA
    CAAGGTACGT TTTGGATGAT GAGTATGTCA GTTCTTTTGG
    AGCCAAGTTC CCAATCAAGT GGTCCCCTCC TGAAGTTTTT
    CTTTTCAATA AGTACAGCAG TAAATCTGAT GTCTGGTCAT
    TTGGAGTTTT AATGTGGGAA GTTTTTACAG AAGGAAAAAT
    GCCTTTTGAA AATAAGTCAA ATTTGCAAGT CGTGGAAGCT
    ATTTCTGAAG GCTTCAGGCT ATATCGCCCT CACCTGGCAC
    CAATGTCCAT ATATGAAGTC ATGTACAGCT GCTGGCATGA
    GAAACCTGAA GGCCGCCCTA CATTTGCCGA GCTGCTGCGG
    GCTGTCACAG AGATTGCGGA AACCTGGTGA CCGGAAACAG
    AATGCCAACC CAAAGAGTCA TCTTGCAAAA CTGTCATTTA
    TTGTGAATAT CTTCACCATA TGGGGTCACT TATGGTGAAT
    ATCTTTCTTC AGAGTTGCTG ACTCTTGAAA ACAGTGCAAA
    GATCACAGTT TTTAAAAGTT TTAAAAATTT AAGAATATTC
    ACACAATCGT TTTTCTATGT GTGAGAGGGA TTTGCACACT
    CTTATTTTTC TGTAAAATAT TTCACATCCC AAATGTGAAG
    AAGTGAAAAA GACTTCGCAG CAGTCTTCAT TGTGGTGCTC
    TTCATGATCA TAGCCCCAGG AACCCTTGAG GTTCTTCTTC
    ACAAGGCTGA GAGTGCTTCC TTCTTGAAGA CGAGTGACAT
    TCATCACTTC AGTGATCCAT GCATAGAATA TGAAAATAAA
    TTCTTCCAAC TCATGGGATA AAGGGGACTC CCTTGAAGAA
    TTTCATGTTT TTGGGCTGTA TAGCTCTTTA CAGAAAATGC
    ACCTTTATAA ATCACATGAA TGTTAGTATT CTGGAAATGT
    CTTTTGTTAA TATAATCTTC CCATGTTATT TAACAAATTG
    TTTTTGCACA TATCTGATTA TATTGAAAGC AGTTTTTTGC
    ATTCGAGTTT TAAACACTGT TATAAAATGT AGCCAAAGCT
    CACCTTTGAA CAGATCCCGG TGACATTCTA TTTCCAGGAA
    AATCCGGAAC CTGATTTTAG TTCTGTGATT TTACACTTTT
    TACATGTGAG ATTGGACAGT TTCAGAGGCC TTATTTTGTC
    ATACTAAGTG TCTCCTGTAA TTTTCAGGAA GATGATTTGT
    TCTTTCCAGA AGAGGAGACA AAAGCAAGAT AGCCAAATGT
    GACATCAAGC TCCATTGTTT CGGAAATCCA GGATTTTGAA
    TTCGAGATGA AACAACCAGC AATCACAGTT AAATCTTAAC
    TTTGCCTGCA CTCTTTGTAG GAATGATCAG AAATTTATCT
    TTATCATTCT GAGTGCTTCA GGAGTACAAT AGGAAGAAAG
    ATACTGGAGA AAGCACTAAT GTAATCACCA TGAAGTCTGA
    CAACAGGAGC CCATTATTTG CGTACTGTCC CACCCTGTAT
    CATGGTTCTC TGGGAACAAG CTTTATGATT CTCATTAGAG
    TTTATTTGTT GATTGTCAGT AGTTGCGACT TTTAAATTAT
    ATTTCCCCCA CTCAAAGAAT GGTATCTTTA TATATCAATG
    ACATTCAATA AATGTGTATT ATTTCTAATG AGAA
    YY2 NM_206923.3 ATTAAATAAG AGAAAAAAGC ATAAAAGGAG TAGGCTTTTT 30
    TGGCAGATAC TGTTATATGG GATGGACAGG AGGGGAAGAC
    ATGAAAATCA ACTAAAATGA AATACATAAA AAATCAGTAA
    AGAGCCTGCT TACGAAAGTG GAAAAACAAC AGCTGGGCGG
    GGTCGCAGGG TGGCAAACGT ACGCGGGCAC GTGCACGTGC
    TTTTGGGGCC GACAGACGCG CCAGTTGCCT AGGCGCATGC
    GTCTGGCTAT CCCAGAAGCA CCTGCGCCTT CCGGCTCGTG
    CTTTCCTCAG TCTCGCGCCT TTCTCTGCAG CTCGCGCCTT
    TCTCTGCAGC TCGCGCCTTT CTCTGCAGCT CGCGCCTTTC
    TCTGCAGCTC GCGCCTTTCT CTGCAGCTCG CCCCTTCCTC
    TGCAGCTCGC CCCTTCCTCT GCAGCTCCCA CCTCACTCCC
    CTCAGCGTTC TTTTTCCCAC GGTCTTCCCG TTGCCGCTAA
    CCTAACTAAC TCTCAGCCAT GGCCTCCAAC GAAGATTTCT
    CCATCACACA AGACCTGGAG ATCCCGGCAG ATATTGTGGA
    GCTCCACGAC ATCAATGTGG AGCCCCTTCC TATGGAGGAC
    ATTCCGACGG AAAGCGTCCA GTACGAGGAT GTGGATGGCA
    ATTGGATCTA CGGTGGCCAC AACCATCCGC CATTGATGGT
    GTTGCAGCCG CTCTTCACGA ACACGGGCTA TGGCGACCAC
    GACCAGGAAA TGCTTATGTT GCAGACACAA GAGGAAGTGG
    TGGGCTATTG CGACTCAGAC AACCAGCTAG GCAACGACTT
    GGAGGACCAG TTGGCCCTCC CGGATAGCAT TGAAGACGAG
    CACTTCCAGA TGACCCTGGC CTCTCTGTCG GCCTCGGCGG
    CATCAACATC AACATCAACC CAGAGCCGCA GCAAAAAGCC
    CAGCAAAAAG CCCAGCGGCA AGAGTGCCAC CAGCACTGAG
    GCCAACCCGG CAGGCAGCAG CTCCAGCCTG GGCACGAGGA
    AGTGGGAGCA GAAGCAAATG CAGGTCAAAA CGCTGGAGGG
    TGAGTTTTCC GTGACTATGT GGTCCCCTAA CGATAACAAT
    GACCAAGGGG CAGTGGGTGA AGGCCAGGCT GAAAACCCAC
    CTGATTATTC CGAGTACTTG AAAGGGAAGA AACTTCCTCC
    TGGGGGGTTA CCAGGCATTG ATCTCTCAGA TCCTAAACAG
    CTGGCAGAAT TTACTAAAGT GAAGCCCAAA AGGTCCAAAG
    GAGAACCTCC CAAAACAGTC CCTTGCTCTT ATAGCGGCTG
    CGAAAAGATG TTCCGGGATT ACGCCGCCAT GAGAAAACAT
    CTCCACATCC ACGGGCCCAG AGTCCACGTA TGTGCAGAAT
    GTGGCAAAGC TTTTCTTGAG AGCTCAAAGC TGAGACGACA
    CCAGCTGGTC CACACCGGCG AGAAGCCCTT TCAGTGCACA
    TTCGAAGGCT GCGGGAAACG CTTTTCCCTT GATTTCAATT
    TGCGCACACA CTTGCGCATC CACACCGGCG ATAAGCCCTT
    CGTGTGCCCC TTCGATGTTT GCAACAGGAA GTTCGCTCAG
    TCAACCAACC TGAAAACCCA CATATTAACG CATGTGAAGA
    CCAAAAACAA CCCGTGAAAA GGAGAAGACC CCTCTCAGAC
    TTGGGAATTA TCTTCCAGGA CTGCGGTAGG GAATAAATAT
    GCCTCTCAAA GCTTTGTATG TTGTTTCTAA GAGTTTTAAA
    AAAAAATGAA TCCTGCACAT TTAAGGTTCG TGTTTTGTTA
    GAGTAGTAAA AATAGAATTT AAACGTTTTT AAAAAGGTAA
    ACCTTGACAT AAGATAATAG TGCTAAGATG CCATAGCTTG
    TTCTGTAACT ATTTTTGTAA AGTTTGGTCC CAACAGGAGA
    AAAATTCGTA GACTTCACAT CAAGAGACGG TTCTTACAAA
    CTGTTTAAAA TGGGACTTTT CACATTCTTA GAAATAGGAA
    GTTCATTTAT TGTTTACAAT GTTTTTAAAA AACTTGTTAA
    AAAATTCAAA GTGTTCATGT TTATACTTTT AGGAATATGC
    TTAATAAGTC TATGTATGGT TTTTCTGGAG GTTGATAACT
    TTGGGAAAGA TTTACTTTAA AAGAGTGAAC AATTATATGC
    ATACGTGAAG TATTTTCCTG CTTAAAAAAG TTATATAGGT
    GTTATTTGTT TTAATCTTGG TTGTAGTCTT GGATGTTAAC
    ACATCTTGCA TTTTAGCTGT ATTAGGTCAT GTAGTATTGA
    TATTAGGTGA TTTAATAGTA CTAGTTTAAA CCTATTTTAG
    TCATTTTATT TTCCCCAAAA TACTACCAGA TGCTGTTGTT
    TAGTGTAATT TCTTTGCCTG TTCAGTTAAA GTAGTGCTTG
    CTTGTAGAAT ATATTGTGTA TATGTTGACT TTAACACTTA
    AGAAGTACAT CCTGTGTAAT AGAAAAAGCA AAATAAAACA
    CCTCTTCTAA AGAAGGAAAA AAGTAGTTTG CCTATATCAG
    TACAGAAGTT AGAACTAAAG AAAAGGGGGA GGGTGCTACT
    GGCATCTGGT GAGTGGAGGG AGATCAGGAA TGCCACTAAA
    CATCCTACAA TGCACAGACA GCCCCACGAA ACACATAATT
    ATTTGGCTAA AATGCCAATA GTGTCAGGTG CAGGGGCTCA
    GGCCTGTAAT GTCAACACTT TGGGAGGCCG AGGTGGGTGG
    ATCGTTTGAG CTCAGGAATT GAACATCAGC CTGGGCAACA
    TGGCATAACT CGGTCTCTAC C
    ALG9 NM_001077690.1 GTCTTTTGTC CCTCGGCGGA CACCGTTTGC CAGCCAAAGC 31
    TATGTCTGCG CGCTCACCGA CTTCATAGGG TGCCGAATTC
    TTTTTTCCCC AGGCTTGCCA TGGCTAGTCG AGGGGCTCGG
    CAGCGCCTGA AGGGCAGCGG GGCCAGCAGT GGGGATACGG
    CCCCGGCTGC GGACAAGCTG CGGGAGCTGC TGGGCAGCCG
    AGAGGCGGGC GGCGCGGAGC ACCGGACCGA GTTATCTGGG
    AACAAAGCAG GACAAGTCTG GGCACCTGAA GGATCTACTG
    CTTTCAAGTG TCTGCTTTCA GCAAGGTTAT GTGCTGCTCT
    CCTGAGCAAC ATCTCTGACT GTGATGAAAC ATTCAACTAC
    TGGGAGCCAA CACACTACCT CATCTATGGG GAAGGGTTTC
    AGACTTGGGA ATATTCCCCA GCATATGCCA TTCGCTCCTA
    TGCTTACCTG TTGCTTCATG CCTGGCCAGC TGCATTTCAT
    GCAAGAATTC TACAAACTAA TAAGATTCTT GTGTTTTACT
    TTTTGCGATG TCTTCTGGCT TTTGTGAGCT GTATTTGTGA
    ACTTTACTTT TACAAGGCTG TGTGCAAGAA GTTTGGGTTG
    CACGTGAGTC GAATGATGCT AGCCTTCTTG GTTCTCAGCA
    CTGGCATGTT TTGCTCATCA TCAGCATTCC TTCCTAGTAG
    CTTCTGTATG TACACTACGT TGATAGCCAT GACTGGATGG
    TATATGGACA AGACTTCCAT TGCTGTGCTG GGAGTAGCAG
    CTGGGGCTAT CTTAGGCTGG CCATTCAGTG CAGCTCTTGG
    TTTACCCATT GCCTTTGATT TGCTGGTCAT GAAACACAGG
    TGGAAGAGTT TCTTTCATTG GTCGCTGATG GCCCTCATAC
    TATTTCTGGT GCCTGTGGTG GTCATTGACA GCTACTATTA
    TGGGAAGTTG GTGATTGCAC CACTCAACAT TGTTTTGTAT
    AATGTCTTTA CTCCTCATGG ACCTGATCTT TATGGTACAG
    AACCCTGGTA TTTCTATTTA ATTAATGGAT TTCTGAATTT
    CAATGTAGCC TTTGCTTTGG CTCTCCTAGT CCTACCACTG
    ACTTCTCTTA TGGAATACCT GCTGCAGAGA TTTCATGTTC
    AGAATTTAGG CCACCCGTAT TGGCTTACCT TGGCTCCAAT
    GTATATTTGG TTTATAATTT TCTTCATCCA GCCTCACAAA
    GAGGAGAGAT TTCTTTTCCC TGTGTATCCA CTTATATGTC
    TCTGTGGCGC TGTGGCTCTC TCTGCACTTC AGAAATGTTA
    CCACTTTGTG TTTCAACGAT ATCGCCTGGA GCACTATACT
    GTGACATCGA ATTGGCTGGC ATTAGGAACT GTCTTCCTGT
    TTGGGCTCTT GTCATTTTCT CGCTCTGTGG CACTGTTCAG
    AGGATATCAC GGGCCCCTTG ATTTGTATCC AGAATTTTAC
    CGAATTGCTA CAGACCCAAC CATCCACACT GTCCCAGAAG
    GCAGACCTGT GAATGTCTGT GTGGGAAAAG AGTGGTATCG
    ATTTCCCAGC AGCTTCCTTC TTCCTGACAA TTGGCAGCTT
    CAGTTCATTC CATCAGAGTT CAGAGGTCAG TTACCAAAAC
    CTTTTGCAGA AGGACCTCTG GCCACCCGGA TTGTTCCTAC
    TGACATGAAT GACCAGAATC TAGAAGAGCC ATCCAGATAT
    ATTGATATCA GTAAATGCCA TTATTTAGTG GATTTGGACA
    CCATGAGAGA AACACCCCGG GAGCCAAAAT ATTCATCCAA
    TAAAGAAGAA TGGATCAGCT TGGCCTATAG ACCATTCCTT
    GATGCTTCTA GATCTTCAAA GCTGCTGCGG GCATTCTATG
    TCCCCTTCCT GTCAGATCAG TATACAGTGT ACGTAAACTA
    CACCATCCTC AAACCCCGGA AAGCAAAGCA AATCAGGAAG
    AAAAGTGGAG GTTAGCAACA CACCTGTGGC CCCAAAGGAC
    AACCATCTTG TTAACTATTG ATTCCAGTGA CCTGACTCCC
    TGCAAGTCAT CGCCTGTAAC ATTTGTAATA AAGGTCTTCT
    GACATGAATA CTGGAATCTG GGTGCTCTGG GCTAGTCAAA
    GTCTATTTCA AAGTCTAATC AAAGTCACAT TTGCTCCCTG
    TGTGTGTCTC TGTTCTGCAT GTAAACTTTT TGCAGCTAGG
    CAGAGAAAGG CCCTAAAGCA CAGATAGATA TATTGCTCCA
    CATCTCATTG TTTTTCCTCT GTTCAATTAT TTACTAGACC
    GGAGAAGAGC AGAACCAACT TACAGGAAGA ATTGAAAATC
    CTGGTACTGG ATGGCTGTGA TAAGCTGTTC TCCACACTCT
    GGCCTGGCAT CTGAGAACTA GCAAGCCTCT CTTAGGCCAT
    ATGGGCTTCT CCACCAAAGC TGTTTGGCAG CTCCTAGCAG
    ACCTTCTTAT TGAAATCCTC ATGCTGAAAA TGAACACAGC
    CTAGTTGCCA ACCCACATGT CCTTTTCACC TCCAGCAAGA
    CTAAGCTTCT TTAAAGCACT TCACAGGACT AGGACCCTGT
    CCTGGAGCTA TCTCAGGAAA AAGGTGACCA TTTGAGGAAC
    TGTGACCTAA TTTTATTATA ATGATGCCTC TAATTTTCAT
    TTCCTTTACA ACCAACTGTA ACTATAAGGT TGTATTGCTT
    TTTTGTTCAG TTTTAGCATG CTATTTTTTG AATTCTAGAC
    TCCTCCATGT GAAGATATCA ACAGACAAAA CTACAACTGT
    ATAGGACATA TTTGGAGAAA ATTCTATCAA TTGATACATT
    TGGATGACAT CACATTTTTA AGTAATGTAA TCTGAGGCCA
    TTGCTGAGGA AATTAAGAAT TTTCCTTTTT TTTTAACCAC
    CCCCAGTGAA AAGGATCAGT GTATATTTAT AGCACCTATT
    TTTTAGTTCT GTCTGTTGTG AGGCACATCC TGCATGGGGC
    ACTTCTAGTC AAATAGGCAA TGATAAGGAC CTAATTAAAA
    TGTGATAAGT GTATACTATT ACTTTAAAAG CCTTTACAGT
    CAGTACTTCA GTTTACAAGG CACTTTCACA GCATCTCGTT
    TGATCCTCAC AGTCACAACA TGTGGTAGAC AAGGCAGGTG
    ATTTTTATCC CCATTTTACA GATAAGGAAA CAGGCTGCGG
    GTGGGGAGTG AGGGGAGGTA AAGATAGTTA GTTGCCTAAG
    GTCACACAGC CAGTAAGTAA TAGAGCTGGG ACTGGAACCC
    AGGTTTCCTT ACTCTCATCT ATTGCTCCTC CATATTCCTC
    ACTCAACCAT GAAAACATTA CTTGAAAGGA CTGATGAGGT
    TAACCAGAGA CCTAACTGAT ATTGTAACTT TCTATTTTAA
    GGAAGAATTG TGTCTGTATT TGAGTTCTTT GGAGCCTCCA
    GTCTGCCTGT GTGTTAGACC AGCACAGCAG TGCTGTGTGA
    TGCAGCCTGA CCTGTGGCAG GAAAGTAGTG CTTCTGTTTG
    GAAGTCATGT TCTTTTGCAG CCACACAGGA TCCAAATATC
    AGTACTATTC CTGTAGTCAA TCTGGGGTCA CATTATAGGT
    GCCTTATTTC CCTAAGGGTA ACTGATCTGA ATATCTGCAA
    ATAGGATGAA TCTATTTTTC AGAAGTTCCA TCTTTCATTT
    TTCTTTTTTT TTTTGAGACA GAGTCTCATT CTGTCGCCCA
    TGCTGGAGTG CAGTGGCGCG ATCTCGGCTC GCTGCAACCT
    CTGCCTCCCA GGTTGAAGCA ATTCTCATGC CTCAGCCACC
    CGAGTAGCTG GGATTACAGG CATGCGCCAT CATGCCCAGC
    TAATTTATGT ATTTTTAGTA GAGTTGGAGT TTCACCATGT
    TGGCCAGGCT GGTCTTGGAC TCCTGACCTC AGGTCATCCA
    CCCGCCTCAG CCTCCCAAAG TGCTGGTATT ACAGGCGTGA
    GCCACCGCAC CCAGCCCCAT CTTTCATTTT CAAAGAGAAG
    GGCATTCTAA TAGGAACTGG TGCCAAGAGA GAAGAAAAGA
    AGTGATAACA GAAGAAATGG CTAGTTACAA TATTAAAAAG
    CTCCTCTTTG AGATCTCCTC TGCAGGAATA TCAGAGACGG
    AGTTGAAGCG CTGGAGAGGT AATAGGTCTA GACAGTACAG
    AACAATAACT GGGGAGTGTG TGAGGATAGA CTGGGCTCCC
    CCTTGCTTGA AAGATCTCTG GCATTTAATT CTCAATTCTT
    GATTACTATT TTCCAGTGTA AAACTAGCAC ATATGATCTG
    ACTACAGGAC AGAGAATTTT AAGTGAAACA TTTGCCTTAC
    TTGCAGTAAT AATGTGCTGT TCTTCACAGT AGCTAAGGCC
    CTCTATGTTT CCCAGAGGTA AATAAGAATC CAGGAATGGA
    GGTCCATCTG TGATGAATGG CTTTTTTCTA ATCAAAGTAG
    TATAATGCTG TTTTATCTGT TTTGTCATCT TGTTTTTTTT
    TTTTTTTAAA AAAACAAAAC CTTAATTATA ATATAGCGCA
    AAGAAAGGCC AGGACTGATG CAGGGATTCC TTGGAAATAT
    CAGTTCCTAT CACTTTTAAA ACCTGATTTT GGATCTCTCT
    GTTCTATGTA TGTCTTTAGT GAGAGCACAA TACATGGCAG
    AACGCTGTGC CAAATGTTAT AGGTAAGGAA TATAGAAATG
    AATGTTTTTT GTTGTGAAGG TGTTTTCATG TGATATTTTA
    TAAACACATT TTAAAAAATC TCCATCACTT TTTAGTATAG
    GAAGGATAGC TTTGCCTGGG AAAAACAGTT TCAACACACC
    TGCTCAGAGT AGCAGTTCTC CCTCAAAAAA GCAGTGTTCA
    GCCTGCACTG ACTGTTCTGC TTGCCAAAAG GAGGAAGCAT
    GCAAGATACT TATTTCTCCA TAGATTGTGG AGTATAGAGG
    GATGTGGGAC TACAGATTAT TATTTTTTTT CCCCGAGACA
    GAGTCTTGCT CTGTCGCCCA GGTTGGAACA CAATGGCACG
    ACCTCAGCTC ACTGCAACCT CTGTCTCCCG GGTTCAAGCA
    ATTCTCCTGC TTCAGCCTCC TGAGTAGCTG GGATTACAGG
    CACACACCAC CACCGCACTC AGCTAATTTT TGTATTTTTA
    GTAGAGGTGG GGTTTTACCA TGTTGGCCAG GCTGGTCTTA
    AACTCCTGAC CTTGTAATCA TCCCGCCTCG GCCTCCTAAA
    GTGCTAGGAT TACAGGCATG AGCCACCGCA CCCGGCCCAG
    ATAATTTTTA ATAGCCTTTG ATCATGGGGT GAGTGAGGGA
    GTAGGTATAC TTGGCAAATG CATGGTTCTC TGATTTCTAG
    CTCTAAAGCA GCCTTATCTG AATCCCCAAA TCTTGTGATG
    CTGAGTACCA TTACTGAACC AGTCTGCACG GTAGGCATCT
    GCTACCAAAA TTTACCTCCT ACCTGGTAGG TGTCATCTGA
    TAAGAAAGAA GACAGGTTAT TTTAATTTTT TGAGATAATC
    ACAGAAAATT GCAGCCCATA CTCTTTATTA CCGAATTCAA
    GTTTGGAAAT AGACCCTTTG TTTTAAATCA TGATGGGTCT
    TTATCCCAAT CATTTATCTG GGTCATTTTT CCAACTTTGG
    AGTTCTAGGA AAGAACCTTG AAAACCTGAT ATGATTCTGC
    AGCATGAGGT CTACGGTGAC CATTTGGGCA AAGCTCCAGT
    GGCAATCATT TATTGTGTTT TGCATTTCCT GGGATTTATT
    GAAATAAGAA TTCACTGTGA TTATGTAGTC TTCTGGCTAG
    TATCAGGCAG CTCTGCTTTT AATTTGGTTA ATTTTATTTT
    CTCTGAAGAG GGAGAAGAGG TACAATTTAA TCTTGGCCTC
    CACAAGCATA TTAAAGCTCA CGTGTTAATC AGTGCATTCT
    TATGCTCCTA CATTAAATGC CTTGGGTAAA TGGATAAATG
    GACATGTGCC CAGCTTTAAT TTTTTTTGCA ACAGAAAGAT
    CAGACTTCCG TATGGCATCG TTGGATTTCA GAGGCTTTCT
    GGTGTATCTG TAAATCTGAA TGTTGCCTTC TGCCAGTCTG
    TATAACCAGG TGATTCATGC TGCAAATGAA ATCAGGAAGC
    AGTAAAGTGT TAAAGCAAGA GTATTGTCCA ATTCACTTGT
    CTTCCTGATC CTTGTACTTT ATTTCACGTG TCGGTGTTTA
    CATTACATAC TTATATTTCC TGTGAAAGAA AGAGTTAAAT
    AAATTGTAGC AGTTTGA
    SEPN NM_031475.2 AGCGGAGCGC CAGGCAGCGC GGAGCGGAGG CCAGGCCCAC 32
    AGCCGCTCCG CCTCCCGGCC CGCAGATCCC CGACGGCCGC
    ACCGCGGGCT CCTCTGGCCC GCAAGAACAC GTGCATGGCG
    TCCTGGGGAA GGCGCTGAGT GCGGAGTCGC GGCGCCGCAC
    GCGGCACCAT GGCCCTGGAG CAGGCGCTGC AGGCGGCGCG
    GCAGGGCGAG CTGGACGTGC TGAGGTCGCT GCACGCCGCA
    GGCCTCCTGG GGCCCTCGCT GCGCGACCCG CTGGACGCGC
    TGCCCGTGCA CCACGCGGCC CGCGCTGGGA AGCTGCACTG
    TCTGCGCTTC CTGGTGGAGG AAGCCGCCCT CCCCGCCGCG
    GCCCGCGCCC GCAACGGCGC CACACCGGCC CACGACGCCT
    CCGCCACCGG CCACCTCGCC TGCCTGCAGT GGCTGCTGTC
    GCAGGGCGGC TGCAGAGTGC AGGACAAAGA CAATTCTGGT
    GCCACAGTCT TGCATCTGGC TGCCCGCTTC GGCCACCCCG
    AGGTGGTGAA CTGGCTCTTG CATCATGGCG GTGGGGACCC
    CACCGCGGCC ACAGACATGG GCGCCCTGCC TATCCACTAC
    GCTGCCGCCA AAGGAGACTT CCCCTCCCTG AGGCTTCTCG
    TCGAGCACTA CCCTGAGGGA GTGAATGCCC AAACCAAGAA
    CGGTGCCACG CCCCTGTACC TGGCGTGCCA GGAGGGCCAC
    CTGGAGGTGA CCCAGTACCT GGTGCAGGAA TGCGGCGCAG
    ACCCGCACGC GCGCGCCCAC GACGGCATGA CCCCGCTGCA
    CGCCGCGGCG CAGATGGGCC ACAGCCCAGT CATCGTGTGG
    TTGGTGAGCT GCACCGACGT GAGCCTGTCC GAGCAGGACA
    AAGACGGCGC CACCGCCATG CACTTCGCGG CGAGCCGCGG
    CCACACCAAG GTGCTCAGCT GGCTGCTGCT GCACGGCGGG
    GAGATCTCGG CTGACCTGTG GGGCGGGACC CCGCTGCACG
    ACGCCGCCGA GAACGGGGAG CTAGAGTGCT GCCAGATCCT
    GGTAGTGAAC GGCGCGGAGC TGGACGTCCG CGACCGCGAC
    GGGTACACGG CCGCCGACCT GTCGGACTTC AACGGCCACA
    GCCACTGCAC CCGCTACCTG CGCACGGTGG AGAACCTGAG
    CGTGGAGCAC CGCGTGCTTT CCCGGGATCC ATCCGCAGAG
    CTGGAGGCTA AGCAGCCGGA TTCAGGCATG TCCTCACCCA
    ATACCACGGT GTCGGTCCAG CCGCTGAACT TTGACCTCAG
    CTCGCCTACC AGCACCCTCT CCAACTACGA CTCCTGCTCC
    TCCAGCCACT CCAGCATCAA GGGCCAGCAC CCTCCATGTG
    GGCTTTCCAG CGCTAGAGCT GCAGACATAC AGAGCTACAT
    GGACATGCTG AACCCGGAGC TGGGCCTGCC TCGGGGCACG
    ATTGGGAAGC CCACACCCCC ACCACCCCCA CCCAGCTTCC
    CCCCGCCACC CCCGCCCCCA GGCACCCAAC TGCCCCCACC
    CCCACCTGGC TACCCAGCTC CCAAGCCTCC TGTAGGACCA
    CAGGCAGCTG ACATCTACAT GCAGACCAAG AACAAACTCC
    GCCACGTGGA GACAGAGGCC CTCAAGAAGG AGCTGAGCTC
    CTGTGACGGC CACGACGGGC TGCGGAGGCA GGACTCCAGC
    CGCAAGCCCC GCGCCTTCAG CAAGCAGCCC AGCACGGGGG
    ACTACTACCG GCAGCTGGGC CGCTGCCCCG GCGAGACGCT
    GGCCGCACGC CCGGGCATGG CGCACAGCGA GGAGGTGCGT
    GCCCGCCAGC CCGCGCGCGC CGGCTGCCCG CGCCTCGGCC
    CTGCCGCCCG CGGCTCACTC GAAGGCCCCT CCGCTCCCCC
    GCAGGCGGCG CTGCTTCCTG GGAACCATGT TCCTAACGGC
    TGCGCCGCGG ACCCCAAGGC GTCCAGGGAG CTGCCACCGC
    CGCCCCCACC GCCGCCGCCG CCCCTGCCGG AGGCCGCGAG
    TTCGCCACCG CCGGCCCCGC CTCTGCCCCT CGAGAGCGCT
    GGCCCTGGCT GCGGGCAGCG CCGCTCCTCC TCGTCCACCG
    GCAGCACCAA GTCTTTCAAC ATGATGTCCC CGACGGGCGA
    CAACTCGGAG CTACTGGCTG AGATTAAGGC AGGCAAGAGC
    CTGAAGCCGA CGCCCCAGAG CAAGGGGCTG ACCACAGTGT
    TCTCAGGCAT CGGGCAGCCG GCCTTCCAGC CCGATTCGCC
    GCTGCCTTCT GTGTCACCTG CACTGTCACC AGTCCGGAGC
    CCCACACCGC CAGCTGCGGG GTTTCAGCCG CTGCTCAATG
    GAAGCTTGGT TCCCGTGCCG CCCACTACTC CTGCGCCGGG
    AGTGCAGCTG GACGTGGAGG CTCTCATCCC CACGCACGAT
    GAGCAGGGCC GGCCCATCCC CGAGTGGAAG CGCCAGGTGA
    TGGTGCGCAA GATGCAGCTG AAGATGCAGG AGGAGGAGGA
    GCAGAGGCGG AAGGAGGAGG AGGAGGAGGC CCGGCTGGCC
    AGCATGCCCG CCTGGAGGCG GGACCTCCTG CGGAAGAAGC
    TGGAAGAAGA GAGGGAGCAG AAGCGGAAAG AGGAGGAGCG
    ACAGAAGCAG GAGGAGCTGC GGCGGGAGAA GGAACAGTCA
    GAGAAGCTGC GGACGCTGGG CTACGATGAG AGCAAGCTGG
    CGCCCTGGCA GCGACAGGTC ATCCTGAAGA AGGGGGACAT
    CGCTAAGTAC TAGAGGCCGC AGACTCCTGT CCGCAGCCTC
    GCAGCTCCGT GGGGCCCTCC GCCCCAGCCC CAGCCAGCCA
    GGCCCTGGTG GAAAGGCTGG GAGCCGCACA GCCCTCCCCT
    CCTGCGCTGG AAACCCTCCC TGACCCCCAC CCTGGCCCCC
    CGTATCCCCA GCCCTTGGCA ACACTGGAGT GCACACGCCG
    CCACGGTTGC CCAGAAAAAG TGCCCAAGCT GCTGACGCAA
    ACAACAACAA ATGCTGCTTA TTTGCATGCC GACTTACATA
    TATTTGCATG TTCGTTGACT ATCAAAGAGT GCAGAGCTCT
    CCCCAGCCCC GTGGGTGGTG ACTTTGTTTT CCTGCGGGGC
    TCAGCCCCCT CCAGGATGCA GCCCCCTCCC CCGCACCCCG
    GAACCGGCGT CGCTGGCGCA TCCTGGGTGG AGGCAGGCCC
    CGAGCTCGGG GAAGGGGTTT TCCCTTCCTC TCTGACCCAG
    ATCTGCGCGC GGCCTAGCCC GGGCCTCATT TCTTATCCCC
    GCCAAGGGTT TCCTCTCAGT CATTTGTTTA CCAGAAACAT
    GAAAACTGCC TGTCTGGCCG GGCCGCACTT GTGGCCCCCG
    GGACCCCACC TCTGGCCCCA CCTCCCTCAA GTCTGCGCCC
    CGTCCCCAGC CAGACCCACT CGCTGCCGGG ACCCTTTCAC
    TGCCCCGGTG GAGTGAATAG AGGATGAGGG GCCCTGACCC
    TGTGTCTCCA ACTGCTGCAC CCCATCCCGA CCCTGTCTCC
    GCCACCTCGC AGCCCCATTA AAGCGCTCTC ATCTGGGCTC
    CGGTTCACTC A
    YWHAQ NM_006826.3 TTGGGCGGTG GACCGCCCCT CGGCCCCGGG GTAGGCTGAC 33
    ACGGGAGGGT CCTCAGCTAA AGCCAAAAGC AGATCAAAGT
    GGTGGGACTC GCGTCGCGGC CGCGGAGACG TGAAGCTCTC
    GAGGCTCCTC CCGCTGCGGG TCGGCGCTCG CCCTCGCTCT
    CCTCGCCCTC CGCCCCGGCC CCGGCCCCGC GCCCGCCATG
    GAGAAGACTG AGCTGATCCA GAAGGCCAAG CTGGCCGAGC
    AGGCCGAGCG CTACGACGAC ATGGCCACCT GCATGAAGGC
    AGTGACCGAG CAGGGCGCCG AGCTGTCCAA CGAGGAGCGC
    AACCTGCTCT CCGTGGCCTA CAAGAACGTG GTCGGGGGCC
    GCAGGTCCGC CTGGAGGGTC ATCTCTAGCA TCGAGCAGAA
    GACCGACACC TCCGACAAGA AGTTGCAGCT GATTAAGGAC
    TATCGGGAGA AAGTGGAGTC CGAGCTGAGA TCCATCTGCA
    CCACGGTGCT GGAATTGTTG GATAAATATT TAATAGCCAA
    TGCAACTAAT CCAGAGAGTA AGGTCTTCTA TCTGAAAATG
    AAGGGTGATT ACTTCCGGTA CCTTGCTGAA GTTGCGTGTG
    GTGATGATCG AAAACAAACG ATAGATAATT CCCAAGGAGC
    TTACCAAGAG GCATTTGATA TAAGCAAGAA AGAGATGCAA
    CCCACACACC CAATCCGCCT GGGGCTTGCT CTTAACTTTT
    CTGTATTTTA CTATGAGATT CTTAATAACC CAGAGCTTGC
    CTGCACGCTG GCTAAAACGG CTTTTGATGA GGCCATTGCT
    GAACTTGATA CACTGAATGA AGACTCATAC AAAGACAGCA
    CCCTCATCAT GCAGTTGCTT AGAGACAACC TAACACTTTG
    GACATCAGAC AGTGCAGGAG AAGAATGTGA TGCGGCAGAA
    GGGGCTGAAA ACTAAATCCA TACAGGGTGT CATCCTTCTT
    TCCTTCAAGA AACCTTTTTA CACATCTCCA TTCCTTATTC
    CACTTGGATT TCCTATAGCA AAGAAACCCA TTCATGTGTA
    TGGAATCAAC TGTTTATAGT CTTTTCACAC TGCAGCTTTG
    GGAAAACTTC ATTCCTTGAT TTGTGTTTGT CTTGGCCTTC
    CTGGTGTGCA GTACTGCTGT AGAAAAGTAT TAATAGCTTC
    ATTTCATATA AACATAAGTA ACTCCCAAAC ACTTATGTAG
    AGGACTAAAA ATGTATCTGG TATTTAAGTA ATCTGAACCA
    GTTCTGCAAG TGACTGTGTT TTGTATTACT GTGAAAATAA
    GAAAATGTAG TTAATTACAA TTTAAAGAGT ATTCCACATA
    ACTTCTTAAT TTCTACATTC CCTCCCTTAC TCTTCGGGGG
    TTTCCTTTCA GTAAGCAACT TTTCCATGCT CTTAATGTAT
    TCCTTTTTAG TAGGAATCCG GAAGTATTAG ATTGAATGGA
    AAAGCACTTG CCATCTCTGT CTAGGGGTCA CAAATTGAAA
    TGGCTCCTGT ATCACATACG GAGGTCTTGT GTATCTGTGG
    CAACAGGGAG TTTCCTTATT CACTCTTTAT TTGCTGCTGT
    TTAAGTTGCC AACCTCCCCT CCCAATAAAA ATTCACTTAC
    ACCTCCTGCC TTTGTAGTTC TGGTATTCAC TTTACTATGT
    GATAGAAGTA GCATGTTGCT GCCAGAATAC AAGCATTGCT
    TTTGGCAAAT TAAAGTGCAT GTCATTTCTT AATACACTAG
    AAAGGGGAAA TAAATTAAAG TACACAAGTC CAAGTCTAAA
    ACTTTAGTAC TTTTCCATGC AGATTTGTGC ACATGTGAGA
    GGGTGTCCAG TTTGTCTAGT GATTGTTATT TAGAGAGTTG
    GACCACTATT GTGTGTTGCT AATCATTGAC TGTAGTCCCA
    AAAAAGCCTT GTGAAAATGT TATGCCCTAT GTAACAGCAG
    AGTAACATAA AATAAAAGTA CATTTTATAA ACCATTTACT
    ATGGCTTTGT AACAATTGCA TACCCATATT TTAAGGGACA
    GGTGAATTTA CTACTTTCTA AAGTTTATTG ATACTTCCCT
    TTTATGTAAA ATGTAGTAGT GATACCTATA TTTCCACATT
    GTGCATTGTG ACACACTTGT CTAGGGATGC CTGGAAGTGT
    ATAAAATTGG ACTGCATTTC TTAGAGTGTT TTACTATAGA
    TCAGTCTCAT GGGCCATCTC TTCCTCAGAT GTAAATGATA
    TCTGGTTAAG TGTTATATGG AATAAAGTGG ACATTTTAAA
    ACTAGCAAAG TTAAAAAAAA AAAAAAAAAA AA
    VPS37A NM_001145152.1 GCAGAGGGGG CGGAGAGCGC CCCCGGGGGC GGGGCACGCA 34
    AGTGACGGCG GCGCGGGTGG TGGAGCGCTG GGCGGCCAGG
    CTCCCTGGCT GGCCGGTTTG GGCGTCTGGG CCGTGAAGGT
    GGGACCTCCT GTTCCGGGCC GCAAGTTTCC CTCTCCAGCC
    GCCCGCCGTT CGTAGCATGT CCCCCAGAAC TCGGGGAGCG
    CAGGCAGGAC AGGCTTAGAG AAGACGCGGT CCCCAGCGCT
    TGGGCCACGG ACGTCCCACC CCGCTCCTCT GTCGCTGGAG
    AACCGCCGGG CCGAGCCACT GGGAGAAGCA GGCCAGAGCC
    TTCCAGGGCC TCCGGCCCGT GGACCCGAGG AGGATGAGCT
    GGCTTTTTCC CCTGACCAAG AGCGCCTCCT CCTCCGCGGC
    TGGGTCCCCC GGTGGCCTCA CCAGCCTCCA GCAGCAGAAG
    CAGCGCCTGA TCGAGTCCCT CCGGAACTCA CACTCCAGAT
    TGCTTCCTCC ACAGTTTCCT CAGGAAAAAC CAGTGATCAG
    TGTTTATCCA CCAATACGAC ATCACTTAAT GGATAAACAA
    GGAGTGTATG TTACCTCTCC ATTAGTAAAC AATTTTACAA
    TGCACTCAGA TCTTGGAAAA ATTATTCAGA GTCTGTTGGA
    TGAGTTTTGG AAGAATCCTC CAGTTTTAGC TCCTACTTCA
    ACAGCATTTC CTTATCTATA CAGTAACCCA AGTGGGATGT
    CTCCTTATGC TTCTCAGGGT TTTCCATTTC TTCCTCCATA
    TCCTCCACAA GAAGCAAACA GGAGTATCAC TTCTTTATCT
    GTTGCTGACA CTGTTTCTTC TTCAACAACA AGTCATACCA
    CAGCCAAGCC TGCCGCTCCT TCATTTGGTG TCCTTTCAAA
    TCTGCCATTA CCCATTCCCA CAGTGGATGC TTCAATACCG
    ACAAGCCAAA ATGGTTTTGG GTACAAGATG CCAGATGTCC
    CTGATGCATT TCCAGAACTC TCAGAACTAA GTGTGTCACA
    ACTCACAGAT ATGAATGAAC AAGAGGAGGT ATTACTAGAA
    CAGTTTCTGA CTTTGCCTCA ACTAAAACAA ATTATTACCG
    ACAAAGATGA CTTAGTAAAA AGTATTGAGG AACTAGCAAG
    AAAAAATCTC CTTTTGGAGC CCAGCTTGGA AGCCAAAAGA
    CAAACTGTTT TAGATAAGTA TGAATTACTT ACACAGATGA
    AGTCCACTTT CGAAAAGAAG ATGCAAAGGC AGCATGAACT
    TAGTGAGAGC TGTAGTGCAA GTGCCCTTCA GGCAAGATTG
    AAAGTAGCTG CACATGAAGC TGAGGAAGAA TCTGATAATA
    TTGCAGAAGA CTTCTTGGAG GGAAAGATGG AAATAGATGA
    TTTTCTCAGT AGCTTCATGG AAAAGAGAAC AATTTGCCAC
    TGTAGAAGAG CCAAGGAAGA GAAACTTCAG CAGGCGATAG
    CAATGCACAG CCAATTTCAT GCTCCACTAT AGATTTTCCT
    GGAAACATGA ACTGCCAAGA GAGGAATGGG ACACAAAACC
    AAACACTGTT TTATATTTAT GGTTTGCAAA CTGGCATTTC
    ATCAGTGGCT AAATTCACAG ATATCCTATA TAGATTGTAT
    ACAGAACTGA GACTGATTTT GTACCGATTA GAATGATTGC
    TATGATCTTT GAGAAATTTT TCTGCACTAT TTGCACTGAA
    ATGTTTATTT ATTGTTGATA AATTGTATCA TATTTAAGTT
    CCACTGCTGT TCCTCTTACC TTGATTAAAT GCCTATGCAT
    GTACTTTTAG CTAGTTTTTA ATATTTTATA AAACTTCATT
    TAAATTTGTA TTTTTAACTT GAAGTTCCAT TTCTTTATCA
    AGGATGGTAT TTAGATTTTT TTCCTCTTAA CCTTTTTTCA
    AAAACTATTT TCAACTGTGA GGAAACCCTT ATTTTTCTTT
    CTTTGTGGAT AAAACTTTCA AAAGCAATTT AAGATATTCA
    TAGTGTTAGG AAACACCAAA CCTGCCTATG TGCCATCTCA
    CAAAAGAAAC TTTTAATACC TACAATAAAT CAAAAGAATA
    AACCAGCTGT TCTTATATAT TGTTTCATTT TTAAAACTAA
    AGATGCATTT AAGAAGCAAT ACAAGTAAAT ATTTTACCTA
    ATAGGAAAAA AAAAAGTTGC CTTTCATTTA AACCATTCCA
    ACAGAAATTC TTATGCTAAT TTAAAACATA TATATATCTG
    GTAGGTTTGT GGTTGGATAG GTTTTCTAAA TTCCTAATGT
    TAAAAACAAT CTTTATGTTA ATATACACTA AATCTATACA
    CAAAAAAAGT CAGTGAACTT TTCTGACCTT TACTGTGAGT
    TACCTTTTCC TAAGAGGAAA GCTATAGTAA TAAGTAAAAT
    TTAATTTTTA GGCAATCCTG ATTTTTAATG AATTTAATTG
    AGTGTTCTTG TATACTACAT TGAGCAGTTT GCTTCTATAC
    CGTGTCACAA AATTCATGTA TTTCTTGAGA AGCCCTAAAA
    GCTCATAAAG GAAAATGCCG TGAACTATGT AGCTCAGGCT
    TGGTAAGGTG CCATCTAAAT TACAAAACAA ACTAATGCAT
    AATTTTGCTT AAATTTCATC CCAGTATGAT TGTCTTCCCA
    ACACCAGCAT ATAGTATAGA TTGTCTGTCT TTTTTATATT
    TTTTAGTTCT TCCTGTACAT GTTTTTGGCA ATAAAGTTAT
    AGGAAGAACA AAATTATTTT GTTAGAATTA AAACATGCTT
    AATATTTAGT CTGTTTGTGG AGGGCAGGTA TTCACGTGGA
    CTGAGATACA ATGTTGGATA CAGAAAATAA CTTTCATTGT
    CTTCCTGACA CTGTGCTAAG GACATGCTGT TAAAGCTTCA
    AAGTGACCAG ATGAGGAAGG AATAATTAAT TATTACTCCT
    GATTTGTAGA TAACTGAGGT AAGAGTGTTT CAAATTTATG
    ATAGTCTTTT GGGTATTCAG AAACCTTTCC TTATACTGCA
    CTGGCCACCA GAGCTTAATT TTCCCAGCAG TTACAGCAAT
    GGGAGATAGA ACAGTCTCAA TCTTTTGCCA ACCATCAGGT
    TCCTAGAAAC CAGGTAGGTG TATCCCATAA CAAGGGAGGA
    GCATACCACA GCCCCTCATT TGATTAATTC ATTTGATCTA
    TCTATGTTAT TAAGTACCTA CTAGGAATAA GGCATTGTGG
    AAATACTATA CAAAGATAAA CATTGTTTAG ATGCTTATCT
    ACTTTCCTTT TCACCAGAAA AACAGAAAAA AAAGAAACAT
    TTTCTTACAG AGTAAAAATG TTCTACATAA TCACATGAGT
    AGTTCATCTC AGTGTTTTTT ATTCTTTAAA GTTGAACTAT
    CCCAGTTTCA TTCTATACCA TTCATTGGAT AACCTTGTTA
    CAACCCAGTC ATGAAACAGA GCAGTGTGAT CAGTTATCTG
    CATTTAACAA ATAGACAAAT CAGTTTACAT AAAGGTTATG
    TATGTCACCC ACGATGAAAA GAATCTGCAT TTGAATATGC
    CCGTATGAAT GTGGGTTCTG TTTTTGCAAC AGAGATTAAG
    TGACCATTTT TTCTAATTTT ATGGCTATAT ATTTTCTTCA
    TAAAAATTGG TCACATCGGA GAAGCAGTGC CACAGGAAAA
    ATGAAATGCA TGTGAAAGTT TGTATTCTGA TTTTACAAGA
    TGAGATAGAA ATCAGAATTA AAGAGGAATA CTTAGGAGTT
    ACTAGGCTAA TCAGTGTACG AATTTGTCAT AGGTAGAGAT
    TTAAAGGTTA ATATCTTAAA ATAGAAGAAA ATTCTAAATC
    AATCAATCAG TGAGATATAA ACTAAACAGA CCCACTTCAA
    AGTTGAAAGA AATTTCTAGG CATAAATTGA GACTAGGAAA
    TTTATATCAG AATAGAGGGT GCTTGACACA TATATATGCT
    TAAATTGAAG GACAGCTCAG ATTCATTTTT AGGAGAAGAA
    AGTAAACTAA TGTGCTCTTA AAGAATAAAA ATTTATTCTA
    TGGTTTCTGT CTCTGATCAT CACCTTCCAT TCTATAAAAA
    GCTCAGTTAC TGATTTGCTG GGTCATGGTC AAAATTCTTA
    CCTATTTATT TCATATCAAC TTTAAAAAAT AAATTACTTG
    CATTCTATAT ATTACTAATT GGGAAGTAAT ATGCCTCAAA
    TCAGTTTTAT ACTGGATTAT TCCCTATGCT TTAAACCACT
    GCTCTCAATA AAACACTTCC TGATTAATGT TTGATTATTA
    GATATTTTAG TCTTGTTGGG GATATTTTAG TCTTGTTGGG
    TTAGCCATGC TCTGAAGAAT CTGTGAAAGT ACAGTAAAGT
    TTTAATAAGC AATAAATGTA ACCTTTTATA TAAATCTCAG
    TGCTAGGTTA ACTTCTAATA AGCAGACGAA CATGTTACAT
    AAATTATAAT GTCTGTCTTG TAAAAAAGTT GAGGGGACTA
    AAAGTTTATG ACTCTGATAT GGAAGTTGTC ATATTAAAAA
    ACTACATTTT AAAACATCAA ATATTTATAC TATTTGCTTT
    TCAAATAAAA GCATAGTGCT GTTTGGCATA
    PRRC2B NM_013318.3 GCAGATCGGG AGCGGTGCCG AGAAAAATTT CCTTACTAGA 35
    TGACATTTCA TCGCAATGTC CGATCGTTTG GGGCAAATTA
    CCAAGGGCAA GGATGGGAAA AGCAAGTACT CGACTCTCAG
    CCTGTTTGAT AAGTATAAAG GAAAATCAGT AGACGCGATT
    AGATCCTCAG TTATTCCTAG ACATGGCTTA CAGAGTCTTG
    GGAAAGTTGC TGCAGCCCGG CGCATGCCAC CGCCTGCAAA
    CCTGCCAAGC TTGAAGTCTG AAAACAAAGG AAACGACCCC
    AACATCGTGA TAGTACCCAA GGACGGGACG GGATGGGCAA
    ACAAGCAGGA TCAGCAAGAC CCAAAGAGTT CCAGTGCGAC
    GGCCTCTCAG CCGCCGGAGT CGCTGCCGCA GCCGGGTTTG
    CAGAAATCTG TCTCCAATTT GCAGAAACCG ACACAGTCAA
    TCAGTCAGGA GAATACAAAT TCAGTGCCAG GTGGACCAAA
    GTCATGGGCA CAGCTGAATG GAAAGCCAGT AGGACACGAA
    GGTGGTTTAA GGGGCTCAAG CCGACTGTTA TCCTTCTCTC
    CCGAGGAATT TCCGACGCTG AAAGCAGCTG GAGGGCAGGA
    CAAGGCTGGC AAAGAAAAGG GCGTCTTAGA TCTGTCGTAT
    GGGCCAGGAC CAAGCCTCCG CCCTCAGAAT GTGACAAGCT
    GGAGGGAGGG CGGTGGGCGA CACATAATTT CTGCCACGTC
    TCTGAGCACC TCCCCAACTG AGCTGGGCAG CAGGAACTCG
    AGTACGGGAG ATGGAGCCCC CTCCTCGGCA TGTACCAGCG
    ATTCTAAGGA CCCCTCTCTC CGCCCGGCTC AGCCTGTCCG
    AAAAGGGGCT TCACAGTTCA TGGGAAATGT ATACCACCCA
    CCTACATACC ATGACATGCT TCCTGCTTTT ATGTGTTCGC
    CGAAGTCATC AGAAAACCAG GGTACAGTGG AACGAGGCTC
    TTTTCCCCTT CCTCAGCTCC GCCTTGAACC TCGAGTTCCT
    TTTAGACAGT TCCAGATGAA TGACCAAGAC GGAAAAGAAA
    ACAGGCTGGG ATTGTCTCGC CCACTCCGCC CACTAAGGCA
    GCTGGTGGAG CGGGCACCAC GGCCCACCAT TATCAATGCG
    GAAAACCTGA AGGGCCTTGA CGATCTGGAC GCCGATGCCG
    ATGATGGCTG GGCAGGCCTC CATGAAGAAG TGGACTATTC
    TGAGAAACTG AAGTTCAGTG ATGATGAAGA GGAGGAAGAA
    GTTGTGAAGG ACGGCAGGCC AAAGTGGAAC AGTTGGGACC
    CTAGGAGGCA GCGGCAGTTG TCAATGAGCT CTGCAGACAG
    TGCGGACGCT AAGCGGACTC GAGAGGAAGG GAAGGACTGG
    GCTGAAGCAG TGGGTGCGTC CCGTGTGGTC CGAAAGGCGC
    CAGACCCTCA GCCACCGCCC AGGAAGCTTC ATGGCTGGGC
    ACCAGGCCCT GACTACCAGA AGTCATCAAT GGGCAGCATG
    TTCCGGCAAC AGTCCATCGA GGACAAGGAG GACAAGCCCC
    CACCAAGGCA GAAGTTCATT CAGTCAGAGA TGTCCGAGGC
    GGTGGAGCGA GCCCGAAAGC GCCGGGAAGA AGAGGAGCGC
    CGAGCCCGGG AGGAGAGGCT GGCCGCCTGT GCTGCCAAAC
    TCAAGCAGCT GGACCAGAAG TGTAAGCAGG CACGAAAGGC
    AGGTGAGGCC CGGAAGCAGG CAGAGAAGGA AGTGCCCTGG
    TCTCCAAGTG CTGAGAAGGC ATCTCCCCAG GAAAACGGCC
    CTGCTGTCCA CAAAGGCTCC CCAGAATTCC CTGCCCAAGA
    GACCCCCACC ACATTCCCAG AAGAGGCACC CACAGTGTCC
    CCAGCAGTGG CACAGAGCAA CAGCAGTGAG GAAGAGGCCA
    GAGAGGCTGG GTCCCCTGCA CAGGAGTTCA AGTATCAGAA
    GTCCCTTCCT CCCCGATTCC AGCGCCAGCA GCAGCAACAA
    CAGCAGGAGC AGCTGTACAA GATGCAGCAC TGGCAGCCGG
    TGTACCCCCC GCCGTCCCAC CCCCAGCGCA CCTTTTACCC
    ACACCACCCC CAGATGTTGG GCTTCGATCC CAGGTGGATG
    ATGATGCCTT CCTACATGGA CCCACGTATC ACGCCCACTC
    GGACCCCGGT GGACTTCTAC CCCTCCGCCC TGCATCCCTC
    AGGACTGATG AAGCCCATGA TGCCCCAGGA GTCCCTCAAT
    GGGACAGGCT GTCGCTCTGA GGATCAGAAC TGTGTGCCCC
    CACTCCAAGA AAGAAAAGTG ACCCCCATCG ACTCACCCCC
    TGTGTGGAGC CCAGAGGGCT ACATGGCACT GCAGAGCAAG
    GGCTACCCGC TCCCGCACCC GAAGTCGAGT GACACCTTGG
    CTATGGACAT GCGTGTCAGG AATGAAAGCT CTTTCTCTGC
    CTCACTCGGA AGGGCAGGGG GCGTAAGTGC TCAGCGCGAT
    CTCTTTGAGG AGAGAGGGGA GGAGTACTTG AGTGCTTTTG
    ACAAGAAGGC CCAAGCAGAC TTTGACAGCT GTATCTCTTC
    TCAAAGAATA GGCCAGGAGC TTTTGTTTCC ACCCCAAGAA
    AATGTTCAGG ATGCAGGTGC TCCTGGGGGT CACACCCAAA
    ACCTCAGGTG TTCCCCATTG GAGCCTGACT TTGTCCCAGA
    TGAGAAAAAG CCAGAGTGTG GCAGTTGGGA TGTTAGCCAC
    CAGCCAGAGA CCGCTGACAC AGCCCATGGT GTTGAGCGGG
    AGACACCCCG GGAGGGGACG GCCTTTAACA TCTCCTCCTG
    GGACAAGAAC GGGAGCCCCA ACAAACAGCC ATCCTCGGAG
    CCTGAATGGA CTCCCGAGCC CCGGAGCTCC AGCAGCCAGC
    ACCCGGAGCA GACGGGCAGG ACCCGGAGGT CGGGACCCAT
    CAAGAAACCA GTCCTGAAAG CCCTCAAGGT GGAAGACAAG
    GAGAAGGAGC TTGAGAAGAT TAAGCAGGAG CTAGGGGAGG
    AGAGTACCCG GCTGGCCAAG GAGAAGGAGC AGAGCCCCAC
    GGCAGAAAAG GATGAGGACG AAGAGAACGA TGCCTCTCTG
    GCCAACTCCT CCACCACCAC TTTGGAGGAC AAAGGCCCTG
    GCCATGCCAC TTTTGGCCGC GAGGCCACCA AATTTGAAGA
    GGAGGAGAAA CCTGACAAGG CCTGGGAAGC CAGACCCCCA
    CGAGAGTCCA GCGATGTTCC CCCCATGAAG AGAAATAACT
    GGATCTTTAT TGATGAGGAG CAAGCCTTTG GGGTCAGAGG
    ACAGGCCCGG GGCCGGGGCC GTGGTTTCAG AGAGTTCACT
    TTTCGTGGTC GGCCTGCTGG CGGAAATGGG AGCGGCCTCT
    GTGGTGGGGG GGTCCTGGGG GCCCGCAGCA TCTACTGCAG
    CAGTCAGCGC AGCGGCCGTG GCCGGGGCCT GCGAGAGTTT
    GCGCGGCCAG AGGACTGCCC CAGAGCCAAG CCCCGACGGA
    GAGTTGCCAG TGAGACCCAT AGCGAGGGCT CAGAGTATGA
    AGAACTTCCC AAGCGCCGCC GGCAGAGGGG CTCCGAGAAC
    GGGAATGAAG GCTCGCTCCT GGAGAGGGAG GAGAGCACCT
    TGAAGAAGGG CGACTGCAGA GATTCTTGGC GGTCCAACAA
    GGGGTGCTCT GAGGACCACA GCGGTCTAGA TGCCAAGAGC
    CGAGGCCCTC GGGCCTTTGG GCGAGCCCTC CCTCCCCGGC
    TGAGCAATTG CGGGTATGGA CGGAGAACCT TCGTCTCCAA
    AGAGTCACCC CACTGGCAGA GCAAAAGTCC AGGCAGCTCT
    TGGCAGGAAT ATGGCCCTTC CGACACATGC GGATCCCGGC
    GACCTACAGA CAGAGACTAT GTCCCAGATT CCTACAGACA
    CCCTGACGCA TTTGGTGGCC GGGGCTTTGA GGACAGCCGC
    GCGGAGGACA AGAGATCCTT CTTCCAAGAT GAACACGTGG
    CAGATTCTGA AAATGCAGAG AACCGGCCCT TCAGGAGAAG
    GCGCCCCCCA CGCCAAGATA AGCCCCCTCG ATTCCGGCGC
    CTCCGGCAAG AGCGGGAGTC CCTGGGCCTG TGGGGACCCG
    AGGAGGAGCC CCACCTGCTG GCAGGTCAGT GGCCAGGCAG
    GCCCAAACTG TGTTCTGGGG ACAAGAGTGG CACTGTGGGC
    CGCAGGTCCC CTGAGCTCTC CTACCAGAAC TCCTCCGATC
    ACGCCAATGA GGAGTGGGAG ACGGCCTCCG AAAGCAGCGA
    CTTCAGCGAG CGGCGGGAGC GGCGGGAAGG CCCTGGGTCC
    GAGCCCGACT CCCAGGTGGA TGGTGGCCTG TCGGGGGCTA
    GTTTGGGTGA GAAGAAGGAG CTGGCCAAGA GGAGCTTCTC
    CAGTCAGAGA CCCGTGGTTG ACAGACAGAG CCGAAAGCTG
    GAGCCGGGAG GGTTTGGGGA GAAGCCCGTT AGGCCAGGTG
    GTGGTGACAC CTCCCCTCGC TATGAGAGCC AACAGAATGG
    GACGCCTTTG AAAGTGAAAA GATCCCCAGA CGAGGCCTTG
    CCTGGAGGTC TTAGTGGCTG CAGCAGTGGG AGTGGCCACT
    CCCCCTATGC CCTGGAGCGG GCAGCCCATG CCAGTGCTGA
    CCTTCCCGAA GCCTCCAGTA AAAAGGCAGA GAAGGAGGCC
    AAGTTGGCTG CTCCGAGGGC AGGTGAACAG GGAGAGGCCA
    TGAAACAGTT TGACCTGAAC TATGGAAGTG CCATCATTGA
    AAATTGCGGG TCCAGCCCCG GGGAGGAGAG TGAGGTGGGT
    TCTATGGTGG GCGAAGGCTT CATCGAAGTC CTGACCAAGA
    AGCAGCGCCG CCTGCTGGAG GAAGAGAGAA GAAAGAAGGA
    GCAGGCCGTG CAGGTGCCTG TCAAAGGTCG AGGCCTTTCC
    TCCCGTATTC CTCCTCGATT TGCAAAAAAG CAGAACAACT
    TATGTCTGGA GCAAGGTGAC GTGACCGTGC CTGGCAGCAG
    CCTGGGCACT GAGATCTGGG AGAGCAGCAG CCAGGCTCTC
    CCTGTGCAGG CCCCAGCCAA CGACTCCTGG AGGAAAGCTG
    TCACTGCCTT CAGCAGCACC GAGACTGGCT CTGCGGAGCA
    GGGTTTTAAG AGCAGCCAGG GAGATAGTGG CGTTGACTTG
    AGTGCCGAGT CTCGGGAGTC GTCTGCGACC TCCTCGCAGC
    GCAGCTCCCC ATATGGGACT CTGAAGCCAG AGGAGATGAG
    CGGGCCCGGC CTGGCGGAAC CCAAGGCCGA CAGCCACAAG
    GAGCAGGCTC CAAAGCCATC TGAGCAGAAG GATTCAGAAC
    AAGGCTCTGG ACAGAGCAAG GAGCACAGAC CAGGACCCAT
    CGGCAACGAG CGTTCTCTGA AAAACAGAAA GGGCTCGGAG
    GGGGCCGAGC GGCTGCAAGG GGCTGTCGTC CCGCCTGTTA
    ACGGGGTGGA GATTCACGTG GACTCCGTGC TGCCTGTGCC
    ACCCATTGAA TTTGGAGTCA GTCCAAAAGA CTCCGATTTC
    AGCTTGCCAC CTGGTTCTGC CTCTGGTCCT ACTGGGAGTC
    CAGTTGTTAA ACTTCAGGAT GCCTTGGCCA GTAATGCAGG
    GTTAACACAG AGTATCCCCA TCCTGCGGCG GGACCATCAC
    ATCCAGAGGG CCATCGGTCT CTCCCCAATG TCCTTCCCCA
    CCGCCGACCT TACTCTGAAG ATGGAGTCTG CGCGCAAGGC
    TTGGGAAAAC TCCCCCAGTT TGCCGGAGCA GAGCTCTCCA
    GGCGGCGCTG GCTCAGGCAT CCAGCCTCCA TCCTCTGTGG
    GTGCCTCCAG CGGGGTCAAC TACAGCTCCT TCGGTGGAGT
    GTCCATGCCA CCCATGCCTG TGGCCTCTGT AGCACCTTCT
    GCTTCTATGC CAGGCAGCCA CCTCCCGCCC CTGTACCTGG
    ATGGCCATGT GTTTGCAAGT CAGCCCCGGC TGGTTCCTCA
    AACGATACCT CAGCAGCAGA GTTACCAACA GGCCGCCGCT
    GCCCAGCAGA TCCCGATCTC CCTTCACACA TCTCTGCAGG
    CACAAGCTCA GCTTGGACTG AGGGGTGGGC TTCCTGTGTC
    CCAGTCCCAG GAGATCTTCA GCTCCTTGCA GCCCTTCAGA
    TCTCAGGTGT ACATGCACCC CAGCCTGTCA CCGCCCAGCA
    CCATGATCCT CTCTGGGGGC ACAGCCTTGA AGCCTCCATA
    CTCGGCGTTC CCAGGCATGC AGCCCTTGGA GATGGTGAAG
    CCGCAGTCTG GCTCACCCTA CCAGCCCATG AGCGGGAACC
    AAGCCCTGGT CTACGAGGGC CAGCTCAGCC AGGCTGCTGG
    CCTGGGTGCC TCCCAGATGT TGGACTCCCA GCTCCCACAG
    CTGACCATGC CACTGCCTCG GTACGGCTCC GGGCAGCAGC
    CACTGATCCT GCCCCAGTCT ATTCAGCTGC CACCTGGGCA
    GAGCCTCTCC GTTGGGGCCC CCCGAAGGAT TCCTCCGCCC
    GGGTCCCAGC CGCCAGTCCT GAACACCAGC AGAGAGCCCT
    CTCAGATGGA GATGAAAGGC TTCCACTTTG CCGACAGTAA
    ACAGAATGTC CCTTCAGGAG GCCCCGTGCC ATCGCCACAG
    ACCTACAGGC CTAGCTCTGC TAGCCCCAGT GGGAAGCCCT
    CTGGATCAGC AGTTAACATG GGCTCTGTGC AGGGACACTA
    CGTGCAACAG GCAAAACAAC GAGTGGATGA GAAACCCAGC
    CTGGGAGCCG TGAAGCTGCA GGAGGCCCCC TCGGCTGCCT
    CCCAGATGAA GCGAACCGGA GCGATCAAGC CTCGGGCTGT
    CAAAGTGGAG GAGAGTAAGG CCTGACAGTG CCTGGCTGCC
    ACCTCGCCTC TCCCTACTGA GGACGGTGCC GCCATGCGGC
    CTCGACACAG CCGACACTCG GGAGCCTCAC CAGATCCACC
    GTCCAAATGC GTGGCCCAGA CTGAGAGACC TCCCTCCTCT
    CCACTCCCGA AAGCTCCGTT GTCAACCAGC TTGCACCCGT
    GGATATATGG CATTGACCCG CTTGCTTTGA TACGAAACAA
    AAAAGCAGAC GACTCCTTCA TCCCATCTGC TCCTACCGTG
    ACTGTGGAGT GACGCCTCCT GTGCAGTGCA GATTTGCCCT
    CCCTGCCTCC TCCCTGTCCT GCCGCGCAGC CAGGGCGCCT
    TCTCAGCAGT GCTTCCGGCC CAGCCGCCCA TCCCTAGGCA
    CAGTGATTTG GCAGCAGGGT CATTTTACTT TGAGGCTTTT
    TGTTTTAAAA TGTAGCCAAG GTTTTTACAA AGGGGAAAGG
    AAAAGAAAAC AAAAACGCAA GCTCCATGTG TATAGCTGAA
    CTTTTATATG TTTCTTGCCA GCCCCTCCGC TCCCTTCCAT
    CTCTAGCCTC TGTCCTGTTT AGTTTGATAC GTCACTGCAG
    TACCTTAAGA GGTGACTCTT AAGAATGCAT CCCCTCCTGA
    TTCCTCAGCT GGTTCACCCT TGAGGTTATT TGCAAAAAGA
    AAAGGAGGTT CTTGAGGGCA CCGATTGCGA GCATTCTGGT
    GCCTGGCTCC CCGCCTGGGA AGCGATGGGG TGCTCAGAGC
    AGCAGGCAGG TTGGGGGAGG GGGGGGGTCA TAGTTGGGTT
    CCAGCTCCTG GCTTGATGAG CCCAGGGCGC TTACAGGCAG
    CCCATGAAGT TGATGACAGT TTTAGCATGA GAATCACACA
    GGGTCCCTGT CCTGGGCTCC TCTAAAGCCA GTGGATGTGC
    TGGGCACCAG AGACAAATCA TGGAGATGGC TGCTGGTGGC
    TCCCAGGTTG GCCCAGATGG GGTGAGCTGA CATACCACAG
    GCCCATCCCA GGCCCCGTGG GCTCTGCTTC TGGGGCTCCA
    TACCCTGCCC TGCAGGGGTG CTGTGTTTTT CACACATTTC
    TTTCCCTGAA GCCTTCTGTA ACCTGTCATT TTCCTTCCTT
    CCTCTTCCGG AGCCTGCTGC TTTCTCTGGA CCTGTCTCCA
    CCTCCCACAC AGCTCATCGT GAACACCACT TGGTGATGGA
    GGGAGTGGAC CCGTGTGTGG TCCCCAAGTG AGGCCACTGG
    GAGTTTGTCC TTTTCCTCCT TTGCTTCACT CCCAGCAGCA
    GACCCAGGTT GTCAGGACAG GAGGGCCTGA GCTAAGCAGT
    AGGCATCAGT CTCGTTTGTC TTCAGACGGC GGGGGCAGGT
    CCAGGGTGAG GCTGGGTGGA GGGCTGACCA AGGTCCAAAG
    GGCCTGCGCA GCCTCCGGGA GGGCAGCTTC TCCAGCCAGA
    GGCTTGTGTG AGCCATCGTG TGCTGGGCTT GTTTTTAAGT
    AAGAAACAAG GAAATCACTC CAGATTCTGT CATTCCAAGG
    AAAGGGAAGG GGACAGTTCA GGTTTCTCAG CTGTTCTTAG
    GGGTCACTGA GCGTCTACCT CCTCCTCCAG AGGAGGCTGG
    CTCAGAACAC CTAGAGGAGG GGGCCGGGGA TGCACCCCCC
    ACCAGAGGCT GCCTTCAGCG TCTCACGGGT GCAGGACAGC
    GCTCAGGCTT GGGCTCTAAG CTCTGTGTCT AGTGTAGAAC
    ATGGGGAAGG AGCATCTTAG GAACTGCTGA AGTAACTTCT
    TACTGCTCTC ACAATTCTAA GGAAGCGGGA GAACGGCCTC
    CTACCAACAG CGCCCACCCC AGAGCTGCCT GGGAAAGGGC
    AGTTTTACTG AAAGGTGCTT TACTGTTCAC CTGCATCTTT
    CAGCAGCTCC CCTCCTGCCC TCACCTGGTC TTTTCCCTCT
    TTATCCCAAG CCTTTATGCT TGAGTCCCTT CCCCAGGGGC
    TGCCCACCCG ACAGTTCCAG GCATTCCCTA CCTGAGCTTC
    TTGTCTGCTT TTCCTTCTCC CACTGCAAGC GGCTGCTTGT
    GGGGCCTGGG ATGAGCCCTC TCTGTCCCCA CCGGCCCTCC
    TTGCCAAGCC ATTCCTGGGT GAGTTCAGGC CTGCGGGAGC
    CACACATTCA TCTCCACCTG GACACTTGAG CCGCATGGCC
    AGACCCCTCC CACCTGATGC GGTGGTGCGT GTGATTTGTC
    AAAAGAAAGC CTTCTGGATG CTGTTAAGAT GTACCCTTCA
    GGTGAACCTG GTATCAGACC CACAGTACTT GCTGTTTGAG
    AAAAAATAAA AACAAAAAGG TCACCTGTTC TCCAGCCCTT
    TTCTCTTACC TGGTATTTCC TTCCTTTCTC CTCCCCCACC
    CCAAATAAAA AAACAAAAAA CACTAGAATT TATTTATATG
    TATTGATGTT GTAGGTCTAG GTGAAAAAAA AAGAAGTAAA
    TGTTTCACTG CTCTATTTAT ATATAATGTC TGAATTAATT
    CTGTGCAGGA AAGGCCAGGA AATTGCATGT GAAGTTCGGT
    GCAGTCACCA CCTGTGTGTG ACCTGAGCTG CAGTCTCTTC
    GCTGAGATGC AGGTTTTAAA TGAGACTTGG GGGGCTGAGG
    GCAGGCCTCA GGCCTCCCAG CGCCCCAACC CCTCCTTGGT
    CTAATGAAAT GCAGTTCTTA GTGCAGAGAT GTTTTAAGGT
    GCAATATATC TCTTCCTTTC CCGTGGTTTT AGAGCCAAGC
    TCAAGGTAGT AGGACGTAGG GTCTTATTTT GTTTTCAAAC
    CCCCATCCTC AGAGCGCAGA TACATGCAGA GGCTTCTGCC
    AGGATACCAC GGGGCCTTAG TGGGAACAGG TGGAGACCAG
    CACTTCCCTT TCCTGCTGCT GAGGTAGGGA TTGGGGGGTC
    AGAACCCACT CACTTTTGCC TGTTAAAGTT GCCCTCCTGA
    CGCTGGCAGC TCTGCCTTGG TCACTGGGGA TGCGGCTCGT
    TGCTCAGCCA CCAGTGGCCT TGCGGTATTG TCCACCATCC
    ACTAGAGTGG GATGAAGTCC AGAGTGTGGG TATACATCTC
    AGATGCCCAT CTACCCACTG GGGACTTCAA TGCCAGCTGC
    ATTTGGTTTG GTTTTCTTAA CTGTTGGCTT CTCCCCACAG
    CGTTTTTTGT TTTTTTTTAA ACATTCATAT TGTTTTCAAA
    CTTGGAATTC ATAGACACTC TGGCTCTAGG TTCCTTAAGG
    GGGAAAACAA AAGATGACTT TATTTCACAT TCAAGAAAAT
    CAGTTCAGTT CCAAAGCTGT GGTCCTTCCA GCCACTTCTA
    GGGACACTGG GGAACCTTGT TAAACGTTGA CATCAGTGCT
    CTCCAGCCGT GCTGTCACCC TCCTATCTTC TGGATCTGCC
    TTCGCGATGG TCAGTGACAG CTTCTGGAAG CTGAGCACAC
    ACAGGTGCAC AGCCATGCTG TGGTCTGGCC TGCTACGGCA
    GCATGGCAGC TCTGGTGGAG CCTTCTCCCT TGCCATTTGG
    TTCCCCTGTG CCAAGTAGCT GCAGGCTGCC CCTCAAATCT
    TCATTTGTCC CTTTTCACTT CCTGCAGAAC AAGCCTGGGT
    TAGAGGGTCT GCTGGAAATG GCCTTTGAAG ACCAAGGATA
    CCAGGATGTG TGCACTCTGT CGTGTTCTGT GATGAATGGG
    AAACGTAGGC TTCCAGAAAG CCAGCTCTCT TCTGAAATGT
    GACGGACCTA AGCAGGAAGT CATCCAGGAC AGGAGTGGCT
    CAGTGTTGGG GATGGACGCT GTCGCCCAGC CATGCTCCAC
    CAGGGCCACC AATGTGTAGT TGGCTGGTGG TCTTCGGGCA
    TGTGAGACCT GCTCTTCACT GTTTCCACCC CACTTGGTGG
    CCTCCAGGAT GGTAGTGGCA CCCTCAGAGC CCCATCTTCA
    GCATGTTCTG AAGCCTCAGA GTGGAAATTC CTGCTAAGGC
    TCTGTGTGGA CGCCTTTCTC CCGTGATCTA AAGGGGACAC
    TGTACTCAAG CTTTTGACCT CATGCCTTGT GTAGTAAAAA
    AGGATTTGGG GGTTTTGTTT GGTTCCTGAG AGGGTTGTGT
    TTTGTTTTTG TTTCCTTTTG TTTATGTTTT GGCCTTTCCT
    CTTTGTCTTT CCATGTAGAC CAGATATTTG AAAGGGCAGA
    CGATGGCTAG AGGTGTAATG TGCAGCTTGT TTATACGGTA
    TTTTGGGAAA CTTACCTTGG ATGGGAAATC GAATCGTGGA
    TTCACCAGGC CGGTGCTGGC ACACTCACCC TCGCCCTTTC
    CCTCCGGTTC AGTACCTATT GTTTCTCCTT TCAAATATGT
    GATTGTACTA GCTCTTTCCA TATGAAAGAA TTCTCCTTAT
    TTAAATAAAA AAAGTTTAAA AA
    DOPEY2 NM_005128.3 TCCCACAGTG CCTGGCCCAG AAGCCTTGCT AAATATTTGA 36
    ACAGGATTGC CCAATACTTT TCTGCTGTGA GAATGTAAGA
    TGGATCCAGA AGAGCAGGAG CTCTTAAATG ATTACAGATA
    CAGAAGCTAC TCTTCAGTGA TTGAAAAGGC TTTGAGAAAT
    TTTGAGTCCT CGAGTGAATG GGCGGATCTC ATATCTTCAC
    TTGGCAAACT CAACAAGGCT CTTCAGAGTA ACCTGAGGTA
    CTCCTTGTTG CCAAGACGGC TCCTCATCAG CAAAAGATTA
    GCTCAGTGTT TGCACCCTGC CCTGCCCAGT GGTGTCCACT
    TAAAAGCTCT GGAAACCTAC GAGATTATCT TTAAAATCGT
    GGGGACCAAA TGGCTGGCCA AGGACTTGTT TCTGTACAGC
    TGCGGGTTAT TTCCTCTCCT GGCACACGCG GCGGTGTCGG
    TGAGGCCGGT GCTGCTCACC CTGTACGAGA AGTACTTCCT
    CCCACTGCAG AAGCTGCTCC TGCCCAGTCT GCAGGCCTTC
    ATCGTGGGCC TGCTGCCCGG CCTTGAAGAG GGCTCCGAGA
    TCTCCGACAG AACGGATGCT CTGCTCCTGA GACTGTCGCT
    GGTGGTTGGC AAAGAGGTGT TTTACACCGC CCTCTGGGGG
    AGCGTCCTGG CCAGCCCGTC CATCCGCCTC CCTGCCTCAG
    TCTTCGTGGT GGGCCACATC AACAGGGATG CCCCCGGCCG
    GGAGCAGAAG TACATGCTGG GGACCAATCA CCAACTCACG
    GTGAAGTCTT TGCGTGCCTC CCTGTTGGAC TCAAATGTTC
    TTGTGCAAAG AAATAATCTG GAAATCGTTC TGTTTTTCTT
    CCCATTTTAT ACCTGTCTGG ATTCCAATGA GAGAGCCATC
    CCCCTCCTCA GATCTGACAT CGTGCGCATT CTCTCAGCCG
    CCACCCAGAC CCTACTGAGA AGGGACATGT CCCTGAACAG
    AAGACTGTAT GCATGGTTAC TAGGCTCAGA CATAAAAGGA
    AATACCGTTG TGCCAGAATC TGAAATCTCA AATTCTTATG
    AAGACCAGTC GTCTTATTTT TTTGAAAAAT ACTCCAAGGA
    TCTTTTAGTT GAGGGTTTGG CTGAGATATT GCATCAGAAG
    TTCATAGATG CTGACGTGGA GGAACGCCAT CATGCATACC
    TGAAGCCTTT TCGCGTCCTC ATCAGTCTGC TTGACAAGCC
    AGAAATAGGG CCTCAAGTGG TTGGGAATTT GTTTCTCGAA
    GTCATCAGGG CCTTTTATTC TTACTGCAGA GATGCCCTTG
    GCTCTGATCT TAAACTTAGC TACACCCAGA GTGGAAATTC
    GCTGATAAGT GCAATCAAGG AAAACAGAAA TGCCTCTGAG
    ATTGTCAAAA CGGTAAATTT GCTGATAACT TCTCTAAGCA
    CAGACTTTCT CTGGGATTAT ATGACAAGGT GTTTTGAGGA
    ATGCTTTAGA CCAGTGAAGC AGCGTTACAG CGTGAGGAAC
    AGCGTCAGCC CTCCCCCCAC GGTCTCGGAG CTCTGCGCCC
    TCCTGGTCTT CCTGCTGGAT GTCATTCCTT TGGAACTTTA
    CTCTGAGGTG CAAACCCAGT ATCTCCCTCA GGTGCTCGGC
    TGCCTGGTGC AGCCTCTTGC TGAGGACATG GAGGCCTTAA
    GTTTACCTGA ACTCACGCAT GCCTTGAAGA CGTGTTTCAA
    GGTGCTCAGC AAAGTCCAGA TGCCTCCTTC CTACCTCGAC
    ACGGAGTCCA CCAGCGGAAC CTCGAGTCCA GTAAAAGGTG
    AAAACGGCAA AATAATTTTG GAAACAAAGG CAGTGATTCC
    CGGTGACGAA GATGCTTCGT TTCCCCCTCT GAAGTCTGAG
    GACAGTGGGA TCGGGCTCAG TGCCTCGTCA CCGGAGCTCT
    CTGAGCACTT GAGGGTTCCT CGAGTTTCTC TGGAAAGGGA
    CGACGTTTGG AAGAAGGGCG GGAGCATGCA GAGGACGTTT
    CTTTGCATCC AAGAGCTAAT CGCCAACTTT GCCAGCAAGA
    ACATTTTTGG AGTACAGCTG ACAGCGTCAG GAGAAGAAAG
    CAAGTCCGAG GAGCCTGCAG GGAAGAGGGA CAGGGATGGG
    ACGCAGAGCC TGGCAGCCAA TGATTCCAGC AGGAAGAACT
    CTTGGGAGCC CAAGCCCATC ACTGTGCCTC AGTTCAAGCA
    GATGCTGTCA GACTTGTTCA CAGCACGAGG GTCTCCATTC
    AAGACAAAAA GTTCAGAGTC ACCATCGTCT TCGCCCAGCA
    GCCCTGCCAG GAAAAACGGG GGAGAATGGG ATGTTGAGAA
    GGTGGTCATT GACCTGGGGG GTTCCAGGGA GGAACGCAGG
    GAGGCCTTTG CCGCCGCCTG CCACCTGCTG CTGGATTGTG
    CCACTTTCCC TGTCTACCTG TCCGAGGAAG AGACCGAGCA
    GCTCTGTGCA ACGCTCTTCC AGCTGCCAGG AGCCGGTGAT
    TCCAGTTTTC CATCTTGGCT GAAGTCCCTC ATGACTATTT
    GCTGCTGTGT GACTGACTGC TACCTCCAGA ACGTGGCCAT
    TTCCACTCTG CTGGAAGTGA TAAACCATTC CCAGTCCCTG
    GCGCTTGTCA TTGAAGACAA GATGAAACGC TATAAGAGCT
    CTGGACACAA CCCTTTTTTT GGCAAGCTGC AGATGGTGAC
    GGTTCCTCCC ATTGCTCCAG GGATATTGAA AGTCATTGCA
    GAGAAAACAG ATTTCTATCA GAGGGTGGCT CGTGTGCTTT
    GGAATCAGCT GAACAAAGAG ACCCGGGAGC ATCACGTCAC
    CTGCGTAGAA TTGTTCTACC GGCTGCACTG CCTGGCCCCT
    ACGGCCAACA TCTGCGAGGA CATCATCTGC CATGCCCTCC
    TGGACCCTGA CAAGGGAACA AGGCTGGAAG CTCTGTTTAG
    ATTTTCCGTG ATCTGGCATC TGACAAGAGA GATCCAAGGC
    AGTCGAGTAA CATCTCACAA TCGCTCCTTT GATAGGTCCT
    TGTTTGTCGT GCTGGACAGC CTGGCCTGCA CGGATGGTGC
    CATCGGTGCG GCAGCCCAGG GCTGGCTGGT GCGTGCGCTC
    TCCCTCGGGG ACGTGGCTCG CATCCTCGAA CCCGTGCTCC
    TGCTGCTGCT GCAGCCAAAA ACCCAGAGAA CCTCCATCCA
    CTGCCTCAAG CAGGAGAACT CGGCCGATGA CTTGCACCGT
    TGGTTTAACA GGAAGAAAAC CTCTTTCAGA GAGGCATGCG
    CAGTGCCCGA GCCTCAGGAG AGCGGCTCTG AAGAGCACCT
    GCCTCTGAGC CAGTTCACCA CAGTGGACCG TGAAGCCATT
    TGGGCCGAAG TGGAGAAGGA GCCCGAGAAG TACCCGCTGC
    GAGGCGAGCT GAGCGAGGAA GAGCTGCCCT ACTACGTGGA
    GCTTCCAGAC AGGACGGCCC ACGGCGCCCC GGACAGCAGC
    GAGCACACCG AGTCTGCAGA TACAAGCTCC TGCCACACGG
    ACAGCGAGAA CACGTCCTCC TTCTCCTCCC CTTCCCACGA
    CCTGCAGGAG CTGAGCAACG AAGAGAACTG CTGTGCACCC
    ATCCCCATGG GGGGCAGGGC GTACCCCAAG CGCTCGGCCC
    TGCTGGCGGC CTTCCAGTCA GAAAGCTTCA AGGCTGGGGC
    CAAGTTAAGC CTGGTGCGGG TGGACTCGGA CAAGACGCAG
    GCTTCTGAGT CGTTCTCCAG CGACGAGGAG GCGGACTTGG
    AGCTCCAGGC CCTCACCACA TCCAGGCTGC TAAAGCAGCA
    GCGGGAAAGG CAGGAGGCCG TCGAGGCCTT GTTCAAGCAC
    ATCCTGCTCT ACCTGCAGCC CTACGACTCT CGGCGGGTCC
    TCTATGCCTT CTCGGTGCTG GAGGCTGTGC TCAAAACCAA
    CCCTAAGGAA TTCATCGAGG CTGTGTCCAG GACTAGCATG
    GATACCAGCT CCACCGCGCA CCTCAACCTC ATCTCCAACC
    TCCTCGCTCG CCACCAGGAG GCCCTCATTG GCCAGAGTTT
    CTACGGAAAG CTCCAGACCC AGGTCCCCAA CGTGTGCCCC
    CACTCTCTGC TCCTGGAGCT GCTCACCTAC CTCTGCCTGA
    GCTTCCTGCG CTCCTACTAC CCTTGCTATT TGAAGGTCTC
    GCACCGAGAC ATTCTCGGCA ACCGGGACGT GCAGGTCAAA
    AGTGTCGAGG TTTTGATCAG GATAATGATG CAGCTGGTCT
    CAGTGGCCAA GTCTTCGGAA GGGAAGAACG TGGAGTTCAT
    CCACAGCTTG CTGCAGAGGT GCAAAGTTCA GGAGTTTGTC
    CTGCTCTCCC TGTCGGCGTC CATGTACACG AGCCAGAAGC
    GCTACGGGCT GGCCACCGCC CACCACGGCA GGGCCCTGCC
    AGAGGACAGC CTCTTTGAGG AGAGTCTCAT TAACTTGGGT
    CAGGACCAGA TCTGGAGTGA GCACCCGCTG CAGATTGAGC
    TGCTGAAGCT GCTGCAGGTG CTGATTGTCT TGGAACACCA
    CCTGGGTCGG GCCCATGAGG AGGCGGAAAA CCAGCCCGAC
    CTGTCCCGGG AGTGGCAGAG AGCCCTGAAC TTCCAGCAGG
    CCATCAGCGC CCTGCAGTAC GTGCAGCCCC ACCCCCTCAC
    CTCCCAGGGT CTTCTGGTCT CTGCGGTGGT GAGGGGTCTG
    CAGCCCGCCT ACGGTTACGG CATGCATCCG GCCTGGGTGA
    GCTTGGTCAC GCATTCCTTG CCCTACTTCG GAAAGTCCCT
    GGGCTGGACG GTGACACCCT TTGTTGTCCA GATTTGCAAA
    AACTTGGATG ACTTGGTCAA GCAGTATGAA AGCGAATCTG
    TGAAGCTCTC TGTCAGCACA ACCTCCAAGA GGGAAAACAT
    TTCTCCAGAT TATCCACTCA CCCTTCTAGA AGGTCTAACG
    ACCATTAGTC ATTTTTGTCT TTTGGAACAA GCCAACCAAA
    ACAAAAAGAC CATGGCTGCA GGTGATCCTG CCAACTTGAG
    GAATGCCAGA AATGCCATTT TGGAAGAGCT GCCTCGAACT
    GTTAACACCA TGGCCCTTCT CTGGAATGTT CTCAGAAAGG
    AGGAGACTCA AAAGAGACCT GTCGATCTCC TAGGGGCCAC
    GAAGGGATCC TCTTCCGTTT ACTTTAAAAC CACCAAAACC
    ATAAGACAAA AAATTTTAGA CTTCTTAAAC CCCTTGACGG
    CCCATCTTGG GGTTCAGTTG ACAGCGGCTG TTGCGGCAGT
    GTGGAGCAGA AAGAAAGCCC AGCGTCACAG TAAGATGAAG
    ATTATCCCAA CGGCAAGTGC ATCCCAGCTA ACCCTTGTCG
    ACTTGGTGTG TGCACTCAGC ACCCTGCAGA CTGACACGCT
    GCTGCACCTG GTGAAGGAGG TGGTGAAGAG GCCACCCCAA
    GTCAAAGGGG GTGATGAGAA ATCGCCCCTA GTGGACATTC
    CTGTGTTGCA GTTTTGCTAT GCTTTTCTCC AAAGGCTCCC
    AGTACCAGCC TTGCAAGAGA ACTTTTCTTC ACTGTTGGGA
    GTATTGAAAG AGTCTGTACA GTTGAATCTA GCCCCACCTG
    GGTATTTTCT GCTTCTCAGC ATGCTGAATG ACTTTGTAAC
    AAGAACTCCC AACCTGGAAA ACAAGAAGGA CCAAAAAGAC
    CTGCAGGAAA TCACTCAGAA AATCCTAGAA GCTGTGGGGA
    ACATTGCCGG CTCTTCCTTG GAGCAAACCA GCTGGCTAAG
    CAGAAACCTG GAAGTGAAGG CCCAACCTCA GGCCTCTCTA
    GAAGAATCTG ATGCTGAGGA GGACCTGTAT GATGCTGCTG
    CAGCTTCAGC AATGGTGTCT TCATCCGCCC CGTCGGTGTA
    CAGCGTGCAA GCCCTCTCTC TCCTGGCAGA GGTACTGGCT
    TCCCTCCTGG ACATGGTTTA TCGAAGTGAT GAGAAGGAGA
    AAGCTGTGCC GTTAATCTCC CGTCTGCTTT ACTATGTTTT
    TCCATACTTA CGCAACCACA GTGCCTACAA TGCTCCCAGC
    TTCCGGGCTG GCGCTCAGCT GCTGAGCTCC CTGAGTGGCT
    ATGCCTACAC AAAGCGAGCC TGGAGGAAGG AGGTCCTGGA
    GCTGTTTCTC GACCCCGCTT TCTTTCAGAT GGATACTTCC
    TGTGTTCATT GGAAGTCCAT TATTGACCAT CTTTTGACTC
    ATGAGAAAAC AATGTTTAAG GATTTAATGA ACATGCAGAG
    CAGTTCTTTG AAACTATTCT CAAGTTTTGA ACAGAAAGCC
    ATGCTGTTAA AGCGCCAGGC TTTTGCTGTC TTCAGTGGAG
    AACTTGATCA ATACCACCTT TACCTTCCAC TGATACAAGA
    ACGCCTGACA GACAATCTCA GAGTTGGACA GACATCCATA
    GTTGCTGCTC AGATGTTTCT TTTTTTCAGA GTTTTGCTGC
    TAAGAATATC TCCTCAACAT TTGACTTCAT TGTGGCCAAT
    AATGGTCTCT GAATTGATTC AGACATTCAC ACAGCTTGAA
    GAAGATCTAA AAGATGAAGA TGAGTCATTG AGAAGCACCA
    ACAAAGTAAA CAGAACGAAA GTTTCAGTCC CGGATGCAAA
    TGGACCCTCA GTGGGGGAGA TACCCCAGAG TGAACTCATC
    TTGTATTTAT CAGCTTGCAA ATTCTTGGAC ACAGCGCTTT
    CTTTTCCACC TGACAAGATG CCATTATTTC AAATTTATAG
    GTGGGCATTT ATTCCAGAAG TGGACACAGA GGGCCCTGCC
    TTCCTGTCGG ATGTAGAGGA GAATCACCAA GAATGCAAAC
    CCCACACTGT CAGGATTCTA GAACTTCTAA AATTAAAGTT
    TGGGGAAATC AGTAGCTCTG ATGAGATCAC CATGAAGAGT
    GAATTCCCGC TTCTGCGCCA ACATTCTGTT TCCAGCATCA
    GGCAGTTGAT GCCATTCTTC ATGACTCTAA ATGGTGCATT
    TAAGACCCAG AGACAGCTGC CTGCTGATAG CCCAGGAACT
    CCATTCTTGG ACTTTCCTGT CACAGATAGC CCAAGGATCT
    TAAAACAACT GGAAGAATGC ATCGAATATG ATTTTCTGGA
    ACATCCAGAA TGTTAACCAT GTGAGAGAGA ATATGTTTAA
    TCCATGTATT GGTACTTTAC TGAAAACCAG GTTATATTCT
    AAAGAAGAAA GAAGGCAGGA TAGTGCTTTT GAACAAGCCT
    ATTTCCATTT TGAAAGTAGA TTTCAGGCTA GGTGCGGTGG
    CTCACACCTG TAATCTCAGC ACTTTGGGAG GCCAAGGCAG
    GCAGATCACT TGAGGTCAGG AGTTCGAGAC CAGCCTGACC
    AACATGGTGA GACCCTGTCT CTACTAAAAA TACAAAAATT
    AGCTGGGTGT GGTGGCGGCG CCTGTAATCC CAGCTACTTG
    GGAGGCTAAG GCATGAGAAT TGCTTGAACC CAGGAGGTGG
    AGGCTGCAGT GAGCCGAGAT CACGACACTG CACTCCAGCT
    GTGTGACAGA ATGAGACCAT CTCCAAAAAA AAAAAAAAGT
    AGATTTCAGA TAATTTACTG TTCAGCAACA GGACACACCT
    CCCTAAATGC CTTGTAATAT ATTTGAATCT GATTCTGCAT
    TTCTTCCTCA ATTTATGTAA TGAAAATAAA ATTAATATAT
    CATCTAACAG TAGCACAAAA TTTGTAATAT GAAGTAAAGT
    ATGAAGATAA TGAAGAAGTT GTTTTCTTTG TTGAAGCAGT
    TATATGGGTC TTTCTCAGTA TATTTCTCTT TTCTCTAAAA
    GTTTAAACTT ATTAAAAGAA TGTTATTTTT AACCTTTCAA
    AAAAAAAAA
    NDUFB11 NM_019056.6 GCTCTGGCCG GCCCCGGCGA TTGGTCACCG CCCGCTAGGG 37
    GACAGCCCTG GCCTCCTCTG ATTGGCAAGC GCTGGCCACC
    TCCCCACACC CCTTGCGAAC GCTCCCCTAG TGGAGAAAAG
    GAGTAGCTAT TAGCCAATTC GGCAGGGCCC GCTTTTTAGA
    AGCTTGATTT CCTTTGAAGA TGAAAGACTA GCGGAAGCTC
    TGCCTCTTTC CCCAGTGGGC GAGGGAACTC GGGGCGATTG
    GCTGGGAACT GTATCCACCC AAATGTCACC GATTTCTTCC
    TATGCAGGAA ATGAGCAGAC CCATCAATAA GAAATTTCTC
    AGCCTGGCCG AAAATGGTTG GCCCCACGAA GCCACGACAA
    CTGGAGGCAA AGAGGGTTGC TCAACGCCCC GCCTCATTGG
    AAAACCAAAT CAGATCTGGG ACCTATATAG CGTGGCGGAG
    GCGGGGCGAT GATTGTCGCG CTCGCACCCA CTGCAGCTGC
    GCACAGTCGC ATTTCTTTCC CCGCCCCTGA GACCCTGCAG
    CACCATCTGT CATGGCGGCT GGGCTGTTTG GTTTGAGCGC
    TCGCCGTCTT TTGGCGGCAG CGGCGACGCG AGGGCTCCCG
    GCCGCCCGCG TCCGCTGGGA ATCTAGCTTC TCCAGGACTG
    TGGTCGCCCC GTCCGCTGTG GCGGGAAAGC GGCCCCCAGA
    ACCGACCACA CCGTGGCAAG AGGACCCAGA ACCCGAGGAC
    GAAAACTTGT ATGAGAAGAA CCCAGACTCC CATGGTTATG
    ACAAGGACCC CGTTTTGGAC GTCTGGAACA TGCGACTTGT
    CTTCTTCTTT GGCGTCTCCA TCATCCTGGT CCTTGGCAGC
    ACCTTTGTGG CCTATCTGCC TGACTACAGG TGCACAGGGT
    GTCCAAGAGC GTGGGATGGG ATGAAAGAGT GGTCCCGCCG
    CGAAGCTGAG AGGCTTGTGA AATACCGAGA GGCCAATGGC
    CTTCCCATCA TGGAATCCAA CTGCTTCGAC CCCAGCAAGA
    TCCAGCTGCC AGAGGATGAG TGACCAGTTG CTAAGTGGGG
    CTCAAGAAGC ACCGCCTTCC CCACCCCCTG CCTGCCATTC
    TGACCTCTTC TCAGAGCACC TAATTAAAGG GGCTGAAAGT
    CTGAAAAAAA AAAAAAAA
    ND4 NC_012920.1 ATGCTAAAACTAATCGTCCCAACAATTATATTACTACCACTGAC 38
    ATGACTTTCCAAAAAACACATAATTTGAATCAACACAACCACCC
    ACAGCCTAATTATTAGCATCATCCCTCTACTATTTTTTAACCAAA
    TCAACAACAACCTATTTAGCTGTTCCCCAACCTTTTCCTCCGACC
    CCCTAACAACCCCCCTCCTAATACTAACTACCTGACTCCTACCC
    CTCACAATCATGGCAAGCCAACGCCACTTATCCAGTGAACCACT
    ATCACGAAAAAAACTCTACCTCTCTATACTAATCTCCCTACAAA
    TCTCCTTAATTATAACATTCACAGCCACAGAACTAATCATATTT
    TATATCTTCTTCGAAACCACACTTATCCCCACCTTGGCTATCATC
    ACCCGATGAGGCAACCAGCCAGAACGCCTGAACGCAGGCACAT
    ACTTCCTATTCTACACCCTAGTAGGCTCCCTTCCCCTACTCATCG
    CACTAATTTACACTCACAACACCCTAGGCTCACTAAACATTCTA
    CTACTCACTCTCACTGCCCAAGAACTATCAAACTCCTGAGCCAA
    CAACTTAATATGACTAGCTTACACAATAGCTTTTATAGTAAAGA
    TACCTCTTTACGGACTCCACTTATGACTCCCTAAAGCCCATGTC
    GAAGCCCCCATCGCTGGGTCAATAGTACTTGCCGCAGTACTCTT
    AAAACTAGGCGGCTATGGTATAATACGCCTCACACTCATTCTCA
    ACCCCCTGACAAAACACATAGCCTACCCCTTCCTTGTACTATCC
    CTATGAGGCATAATTATAACAAGCTCCATCTGCCTACGACAAAC
    AGACCTAAAATCGCTCATTGCATACTCTTCAATCAGCCACATAG
    CCCTCGTAGTAACAGCCATTCTCATCCAAACCCCCTGAAGCTTC
    ACCGGCGCAGTCATTCTCATAATCGCCCACGGGCTTACATCCTC
    ATTACTATTCTGCCTAGCAAACTCAAACTACGAACGCACTCACA
    GTCGCATCATAATCCTCTCTCAAGGACTTCAAACTTACTCCCAC
    TAATAGCTTTTTGATGACTTCTAGCAAGCCTCGCTAACCTCGCC
    TTACCCCCCACTATTAACCTACTGGGAGAACTCTCTGTGCTAGT
    AACCACGTTCTCCTGATCAAATATCACTCTCCTACTTACAGGAC
    TCAACATACTAGTCACAGCCCTATACTCCCTCTACATATTTACC
    ACAACACAATGGGGCTCACTCACCCACCACATTAACAACATAA
    AACCCTCATTCACACGAGAAAACACCCTCATGTTCATACACCTA
    TCCCCCATTCTCCTCCTATCCCTCAACCCCGACATCATTACCGGG
    TTTTCCTCTT
    MORF4L1 NM_001265603.1 CGGCGTGCCC TGGGGCGGCG CGGGCGCAGG GGCGCGTGCG 39
    CGGCGGGCTG TCGTTGGCTG GAGCAGCGGC TGCGCGGGTC
    GCGGTGCTGT GAGGTCTGCG GGCGCTGGCA AATCCGGCCC
    AGGATGTAGA GCTGGCAGTG CCTGACGGCG CGTCTGACGC
    GGAGTTGGGT GGGGTAGAGA GTAGGGGGCG GTAGTCGGGG
    GTGGTGGGAG AAGGAGGAGG CGGCGAATCA CTTATAAATG
    GCGCCGAAGC AGGACCCGAA GCCTAAATTC CAGGAGGTTG
    GGATGAATGG GTTCCGGAGA GCAGAGTACT CAAATACGTG
    GACACCAATT TGCAGAAACA GCGAGAACTT CAAAAAGCCA
    ATCAGGAGCA GTATGCAGAG GGGAAGATGA GAGGGGCTGC
    CCCAGGAAAG AAGACATCTG GTCTGCAACA GAAAAATGTT
    GAAGTGAAAA CGAAAAAGAA CAAACAGAAA ACACCTGGAA
    ATGGAGATGG TGGCAGTACC AGTGAGACCC CTCAGCCTCC
    TCGGAAGAAA AGGGCCCGGG TAGATCCTAC TGTTGAAAAT
    GAGGAAACAT TCATGAACAG AGTTGAAGTT AAAGTAAAGA
    TTCCTGAAGA GCTAAAACCG TGGCTTGTTG ATGACTGGGA
    CTTAATTACC AGGCAAAAAC AGCTCTTTTA TCTTCCTGCC
    AAGAAGAATG TGGATTCCAT TCTTGAGGAT TATGCAAATT
    ACAAGAAATC TCGTGGAAAC ACAGATAATA AGGAGTATGC
    GGTTAATGAA GTTGTGGCAG GGATAAAAGA ATACTTCAAC
    GTAATGTTGG GTACCCAGCT ACTCTATAAA TTTGAGAGAC
    CACAGTATGC TGAAATTCTT GCAGATCATC CCGATGCACC
    CATGTCCCAG GTGTATGGAG CGCCACATCT CCTGAGATTA
    TTTGTACGAA TTGGAGCAAT GTTGGCTTAT ACACCTCTGG
    ATGAGAAGAG CCTTGCTTTA TTACTCAATT ATCTTCACGA
    TTTCCTAAAG TACCTGGCAA AGAATTCTGC AACTTTGTTC
    AGTGCCAGCG ATTATGAAGT GGCTCCTCCT GAGTACCATC
    GGAAAGCTGT GTGAGAGGCA CTCTCACTCA CTTATGTTTG
    GATCTCCGTA AACACATTTT TGTTCTTAGT CTATCTCTTG
    TACAAACGAT GTGCTTTGAA GATGTTAGTG TATAACAATT
    GATGTTTGTT TTCTGTTTGA TTTTAAACAG AGAAAAAATA
    AAAGGGGGTA ATAGCTCCTT TTTTCTTCTT TCTTTTTTTT
    TTTCATTTCA AAATTGCTGC CAGTGTTTTC AATGATGGAC
    AACAGAGGGA TATGCTGTAG AGTGTTTTAT TGCCTAGTTG
    ACAAAGCTGC TTTTGAATGC TGGTGGTTCT ATTCCTTTGA
    CACTACGCAC TTTTATAATA CATGTTAATG CTATATGACA
    AAATGCTCTG ATTCCTAGTG CCAAAGGTTC AATTCAGTGT
    ATATAACTGA ACACACTCAT CCATTTGTGC TTTTGTTTTT
    TTTTATGGTG CTTAAAGTAA AGAGCCCATC CTTTGCAAGT
    CATCCATGTT GTTACTTAGG CATTTTATCT TGGCTCAAAT
    TGTTGAAGAA TGGTGGCTTG TTTCATGGTT TTTGTATTTG
    TGTCTAATGC ACGTTTTAAC ATGATAGACG CAATGCATTG
    TGTAGCTAGT TTTCTGGAAA AGTCAATCTT TTAGGAATTG
    TTTTTCAGAT CTTCAATAAA TTTTTTCTTT AAATTTCAAA
    GAACAAAAAA AAAAAAAAA
    MRPL19 NM_014763.3 GTAGTCTTGA CGTGAGCTAG CTGGCATGGC GGCCTGCATT 40
    GCAGCGGGGC ACTGGGCTGC AATGGGCCTA GGCCGGAGTT
    TCCAAGCCGC CAGGACTCTG CTCCCCCCGC CGGCCTCTAT
    CGCCTGCAGG GTCCACGCGG GGCCTGTCCG GCAGCAGAGC
    ACTGGGCCTT CCGAGCCCGG TGCGTTCCAA CCGCCGCCGA
    AACCGGTCAT CGTGGACAAG CACCGCCCCG TGGAACCGGA
    ACGCAGGTTC TTGAGTCCTG AATTCATTCC TCGAAGGGGA
    AGAACAGATC CTCTGAAATT TCAAATAGAA AGAAAAGATA
    TGTTAGAAAG GAGAAAAGTA CTCCACATTC CAGAGTTCTA
    TGTTGGAAGT ATTCTTCGTG TTACTACAGC TGACCCATAT
    GCCAGTGGAA AAATCAGCCA GTTTCTGGGG ATTTGCATTC
    AGAGATCAGG AAGAGGACTT GGAGCTACTT TCATCCTTAG
    GAATGTTATC GAAGGACAAG GTGTCGAGAT TTGCTTTGAA
    CTTTATAATC CTCGGGTCCA GGAGATTCAG GTGGTCAAAT
    TAGAGAAACG GCTGGATGAT AGCTTGCTAT ACTTACGAGA
    TGCCCTTCCT GAATATAGCA CTTTTGATGT GAATATGAAG
    CCAGTAGTAC AAGAGCCTAA CCAAAAAGTT CCTGTTAATG
    AGCTGAAAGT AAAAATGAAG CCTAAGCCCT GGTCTAAACG
    CTGGGAACGT CCAAATTTTA ATATTAAAGG AATCAGATTT
    GATCTTTGTT TAACTGAACA GCAAATGAAA GAAGCTCAGA
    AGTGGAATCA GCCATGGCTT GAATTTGATA TGATGAGGGA
    ATATGATACT TCAAAAATTG AAGCTGCAAT ATGGAAGGAA
    ATTGAAGCGT CGAAAAGGTC TTGATTCTGA GAATGAATTT
    GGTTAGTTGC AGAAGATACA TTGGCTCTAA GAGGATATAT
    TTTGAGACCA ATTTAATTTC ATTTATAAGA ACATAGTAAT
    TAAGTGAACT AAGCATTCAT TGTTTTATTA ATACTTTTTT
    TCTAAAATAA AACTTGTACA CCAGTTTATT ACTCTAAAAA
    GAGAATTACA CATGCCAAAT GGACCAATGT CCATTTGCTT
    ATTGGAGGCA AAGCTACAAT AGAAGTCAGA GCATCACCAG
    AATGGTCTTT AATGAGCATG GAACCTGAGC AAAGGGAATA
    GGTGGGATGA ATTTTTTTTT TAATTGTGAA ACAATTCATA
    AGCACAATAT GATTTACAGA ATAATAAACA TTCATGTACC
    CACTATCAGG TTAAGAAATA GAACATTTAT TAATATGTAG
    GAATGTTAAG AAATAAAACA TTTAATAAGA TCTCAGAAGA
    CTCCAGTAAA TCTGCAATTG TATCTCTCTC CTTTTTAAAT
    GTAAATATCA TCTTGACTTG TTAATTATTC CCTTGCATTT
    CTTTTAGTTT ACTGCCAACA CATATATTCT TCAACAATAT
    ATTTAATTTT GAAAAACCTG AAAAAAAAAA CCTGTTAGCA
    AGTATAAAGG GGCAGTATTA CTATTATTGC ATGAAGGCTT
    CAAGGGAAAC GTTACAGTCT TTGGGTCATA GTCTGGCTTC
    AGCTTCCTCT GAGAGTTTAC AGAGGCCAAT TTTGAGCAAA
    TTCATGGCTA AGGTTATGAG TGAGTTCTGC TAAACAGAAG
    GCTCACCACA AGGTATCTGG CAGGATTATA CTGGGTAGCT
    GGATGTTGCA GAAATGTGGT TAGAGGAAGT AAACTGTTTT
    TTGATGCTCA CAGCATGATG AATCAAACTC TGTATCTTAG
    GATTAGGTTA AAACAATACC TTTGGTATGA TATGAGTGTT
    GTTGCTGATC CATGCAGCAT GGATTGGAAA GCTGGGGTAT
    AAGCACACAT GCTAAAGAAA AACATGTAAT TTGGTCCATA
    CTCACCTGGA TATACTGTTC CTCAGGTTAA AAAATACAGT
    ACTATCCTAA ATCTTGAAGG CAACTCTCAG CCTATCCATT
    GAGTTACCTT CAGATCTGCC CTCTGGTTCC TAGCTGTCTT
    GGGACTAACT TCTTTCCTGC GCTCAGCTGT TTTCTGGATT
    CCATGTTTTC CATTTTATTG AGTACTAACT TGTTTTGCTG
    CAGCACATCC TTTGGTAGCT TCTAGAGGAA GTTTGTGTGG
    AGGTAAAATT TTTGAGACCT TGCATGTCTC ATGTTTGATT
    GATACTTTAT ACGTTTAGGT AGGAGGTAAT TTTCCTTCAG
    GACTTTAAAA ATATTGTTGC TCCATTTTCT TTGTTTCTAT
    TGTTGTATTG AGAAATCCAA TGCCATTTTG ATTTCCCCAT
    CATAAATTTC ATGATGATGT GTCTTGGTGT GGGTCTATAT
    TTATCCATTG TATTGGGTTT TAGGTGAACC CTTCCAGATA
    GTAACTCATT TCTGTCAGTT CTGGGAAACA CTTAGCATTG
    GTTGATGATT TATTCTCTGC TGCTTTGTTC TCCCAACTAT
    TATTTGGATG TTGGATATCC AGCACTGGGT ATCTATTTTC
    TTACCTCCCT CCCTTGACCC CAGTCTCTGT TTTTTAGCTC
    TTTAGCTCAA TCTTCCAACT CTTTGCTATT GTATTTTAAA
    ATCTTAAGAC CCCTTCTTGA TTTGTAGAAG TTCCTTTTCT
    TACAACCAAA AAGCCTTTAT CTATGGATTT GTTCACAGAT
    AAGGGGTATT CAATATAGTG TATTTTTTTT TCATTTAAAA
    TTGTTTGCGC ATCTATTTCC TCCAAATTTC TTTCTGTATT
    TATTTTTTGT TGTCTATATT TCAGACTTTT CCAGGATATC
    TGATAATCTT TGGCTGTCTT CTTATGGTTG AAAGAGGGAC
    TAAAAAGCTT GGAAAGCCTT TGGGTTGTGG GAAGGGGCTG
    TCTTTAGGAT TATCTGAATG GGCTTTTTTG GGAGTCCCCT
    CCTCCACATG AATATTTTGG TTTTGTCAGA TTCCCTAGAA
    TAGAGGCTTC CAATCTCCTT CCTGGAGGGG TCTGTCCAGG
    AAGGAGATTG TCTAGGGGTC TGTCAGACAG CAGCTTTCAG
    CTACTTCCTT GATCTTTTTC ACTAATGATT ATATAGTCAT
    CTAACTACTG TCAACAAGTA ATAGATATCC TATCCTTCAC
    TTGTTTAGAT TATTTGCTGA GATAACCTCT CAAAAGAACC
    TCTCAAAATA AAAGGTTAAC AAGAGCCTAT ATCTTATATT
    TTTCTTCTCT TTATCTTGTT AGAAGATAGC TATTAAAACC
    TGTTCTTTTT CTGTCTTGAT AAACACACTT CAATCTTGGT
    AGAATGGTAG ATGGGACAGT ATATTTTAGG ACCTAAAGCT
    CTGCAAATGT ATGATCAGCT TGTAAGTACA GGTGCTCAAA
    AACATGTAAA CAATCATGCT TTTTACTCTG TAGGAATATC
    TTTAAAATTC TTGTGAATTT TTCCCCAGAA GTAAAGCAAA
    TCTTCCCCCA GAAATAAAAT TAAATGTGCA TAATCTAAAG
    CTTTTTTTTT TTATTGTGGT AGGATATATA TATAAAACAT
    AATTTGCCAT TGTAAACATT TTAAATTTAC AAGTCAGAGG
    CATTAATTAC ATCACAATGT TGTGAAATTA TTACTACTAT
    TTCCAAAATT TTCTCATCAC CCCAAACTGA AACTCTGTAA
    CTGTTGAGCA ATAACCTCAT TCCTGTATCT CTCCCAACCC
    CAGGTAACCT CAAATCTTTC TTTTTATCTT TGAGACAAGG
    TCTCATTCTA TCACTCAGGT AGGAGTGCAG TGGTGTGATC
    ATAGCTCATT GCAGCCTCAA AATCCTGGGC TCAAGCAATC
    CTCCTTGAGT AGCTAAGACT ATAGGCACAC ATTAACTGCG
    CCTGGCTGAT TTTGTTTTTT GTAGAGATGT GGTCTTGCTA
    TGTTTCCCAT GCTGGTCTTG AGTTCCTGGC CTCAAGCAGT
    CCTTAAGATT CATCCATGTT GTGGCATGTG TCAGAATTTC
    ATTTGTTTTT ATGACTAAAT AATATTCCAT TGTATGTATA
    TACATTTTGT TCATCCATCT TCTGATGAAC ACTGGGATAT
    GTCTACCTTT TGGCTATTGT GAATAATGCT GCAGTAAACA
    TTGACATAAC AAGTATGTAT TTGATTGCCT GTTTCTAAGT
    TCTTTTGGGT ATACATCTTG AGTAGAATTG CTAGATAATG
    TCATGTTTTA TTTCTCTTGT GATTTCTTCT TCGATCCCCT
    GGTTGAGTGT GTTAATTTCT ACATGTTTAT GAATTTCCCA
    CTGTTTTTTT GTTATTGATT TCCAAGTTCA TTCCATTGTG
    ATTAGAGAAG ATACTTAGTA TGATTTTAAT GTTTTTGAGA
    ATTGGTGTGT GGCCTGATAG ATGGTCTGTC CTGGAGAATG
    TTCCTCATAC ACTTGAGCAA AATATTTATC ATGCTATTGT
    TGACTGTAGT TTTCTATATG TCTCTTAGGT CAAGGTGGTT
    TACAATGTGT TAAGGTTCTC TTTTTTTAAA AAAATTTTTG
    CACAGAGTAT CTTTTTCTAT GTGTTCCATG TATTTGTGTC
    TTTGGAGCTA TAGTCTCTTG TAGACAGCAT ATCACTATCT
    TGTTTTGTTT TGTTTTTTCT GTCCATTCTG CCAATTTCTG
    CCTTTTGATT GGAAAATTTA ATCCATTTGC ATTTAAAGTA
    ATTAAGGAAG GACTTTCTTC TACCATTTAA CACTTCTTCT
    ATATGTCATA TACTTTTTTG GCCCCTCATT TCCTCTTTAT
    GGCCTTCTTT TCTGTTTTTT TGTAGTGAAC TAGTCTGATT
    CTCTTTCCAC TCCCCTTTGT GTATATTTGT TAGATGTTTT
    ATTTGTGGTT GCTATGGGGA TTATAGTTAA CATCCTACAC
    TTAAAACAAT CTAATTTAAA CTGATACCAA TTTACCTTCA
    ATAGCATACA AAATCTCTAC TCCTGTAAAG CTCTGCCCCT
    GCCCCCCTTA TGTTATTGAT GGCACAAATT GCCTAATAAA
    TAATTTATAG TTATTTGTAT GAGTTTGTCT TTTAAATCAT
    TTAGGAAATA AAAAGTGGAG TTAGAAAACA GTATGATAGT
    AATACTGACT TTTATATTTG TCAATATATT TATCTTATTT
    TGGATCCTTA TTTCATTATA TAGATTTGAG TTACTGTCTA
    GTGCCCTTCC ATTTCGGCCC AAAGGATTCC CTTATGCATT
    TCTTGCAGGG CAAGTCTAAT TGTAATAAAC TCCCTCAGCT
    TTTGTTTTAT CTGAGAATGT CTTGATTTCT CCCTTATTTT
    TGATGGATAA TTTTGCCAGA TACATGAATT TTTGGTAACA
    GTATTTTTCT TTCAGCACTT TAAATATGTC ATCCCACTAC
    CTTCTGACTT CATGGTTTCT CATGAGATAT TAGATGTTAT
    AAAATTTGAG GATTCCTCAT TCTTGATGAG TCAGTTCTGT
    CTTATTGCTT TTCGGATTTG CTCAGCTTTT GTCTTTTGAC
    AGTTTGATTA TAACGCGGCT CAGTGTGGGT CTCTGAGTTT
    ATCCCACTTA GAGTTTGTTG AGTTTCTTGG AGTCATAGAT
    TTATGTCTTT TATCAAATTT TGGACATATT TGGCTATTAT
    TTCTTCAATT TTTTTCACTG CTTCTTTCTT TTCCTTCTGA
    AATATTCTTA ATGTATATGT TGGTCTGTTT GATGCTGTCT
    CACCAGTTTC TTAGGCTGTG TTCTCTTTTG TTCCTCAGAC
    TTGATTATTG CAGTTGCCCT TCTTTTTATT TTTTTCAAGT
    TTGTTGATTC TTCTCCCTGT TCAGATCAAC TGTTGAACTC
    CTCTAGTGAA TTTATTTCAG TTACTGTACT TTTCAGCTCC
    AAGATTTATC TTTGGTTCCT TTTTATAACG TCTGTGTCTT
    TATTGATATT CTCATTTTGT TCATATGTCT CTTTCTTCCT
    TTAGTTCTTT GTCCATGTTT TCCTTTAGCT CTTTGGGCTT
    ATTTAAGACA ATTGTTTAAA GTCTTTGCAT AGTAAGTCCA
    ATGTCTGTGT TTCTTCAGGG ATGGTTTTCA TTATTTTGTT
    TTCAATGAGC CATACTTTCC TGTGTCTTTG TATGCTGTCT
    TTTTGTTGTT GAAAACTGTA TGTTTGAACA TCATAACGTG
    GTGGCCCTGA AAATCAGATA TTCCCCCCTT CCTGAGAGTT
    AGTTTTATTT TTATTATTGA AGATTGTAGC AGTCTATTGC
    TACATGTGCA GTCATTTCCA AACTATTTTT GCAAAGACTG
    TATTCCTTCT GTGTGTCATC ACTGAAGTCT CTGTTCCTTA
    GTTTGTGTTT AATAGTTTGA CATAGATTTC CTTGAAAGGA
    GTTAAAACTA GCAGAAAAAT CTCTCTCCCA GTCTTTCCAG
    TCTTTGTAGA TTGGTTCTGT GCTGGGCTTT TCCATTAATA
    CTTAGCCAGG CTTGTACTGA GCCTAACAAT CAGGCCCAAA
    AGCGTAGGGT CTTTGCAGAT CTTGTCTGAG CATGCTTCTT
    GCTGTGTATG CACGTAGTTT TCTAAATCTC CCTGTATGTG
    CTGTTGAATA TTCTAATTTC CCAAAGAAAC TCCTTTGCAG
    CTTTTTCTCA CAGAACATAG ATGGTTTTTT GGATATCTTG
    ACCATAGTCT TTCGACCCAG GTGTTTGCGG TTGTTAGTTC
    ACCTTACACT TTTTTCAAGC ATTGCCTACT GCTTACGATG
    AGTGCTCTGT CAATCCTTTA AGTAGCCCCA GACAGGCTAC
    CAGAGACTTA AACAAGAATT TGTAAGTTCT GCTCAGCTTC
    CTCTAGAAAT GGGGATCAGG GTCCAAGACA GAATGCAGTT
    GCTGATTTCA AGACTGCTGC AACACCAGGG AGCTTGTGGG
    GGAAGGGCAA GCAGAAATGT CACAAAGCTT TCTTGCCATT
    TTAAAGTTGC CTGTTCTTGA CTCAGCATTT GCTTCATTGC
    TATAAACTTT TTACTGTTTT TCAGAGTTCT GATAAAATTG
    GCTATGCCTG TTCCTGCTTT AAAAAATATA TATATATTTT
    TTAGGGATTG GGGTCTCACT ATACTGACCA GGCTGGTCTT
    GAACTTCTGG CCTCAAGCCA TCCTCTCATT TCAGCTTCCC
    AAAGTGCTGC AATTACACGC GTGAACCACC ACACCCAGCC
    CCTGCTTGTT TTTCAATGTG CCTACTCCAC CATGTTGCTC
    AAGTATGTAT ATTTTCTAAA CTACCTTGTA GTGTTGTGAT
    GGGAAATAAA TCCCTGAGCC TTTTGAATAA CTCAGAGAGA
    TCAAAAACTT AGTTTATCCT ATTCGAAGGA TTAGAAAAAT
    GATATATCTT TCACTTTTTC AGGGATAGGC TCCTCATTAG
    AAGGCTCCTA TGTGCCGATG CTGTACAAGA CATTTCATTT
    CTCTTAATGT TTACAACAAG CTTGTTGCCA AGGCTGATCT
    TGAACTCCTG GCCTCAAACG ATCCTCCCAG CTCAGTCTCA
    CAAAGTGTTG GGATGTCTGG CCAACTAATG ACTATCTTAA
    CTCTTGTGTT TCAATGTTTA TGCCTTCTTT TATCTTGACT
    GATTGTATGA CTATGTCTTC TAGAACAATG TTGAACAGAA
    ATGGTGAGAG CAGACATCCT TGCTTTAATA TTTCACCATT
    ATATATGATG TTAGGTATAG ATTTTTCTCA CAGATGCCTT
    TTATCAGATT GAGGAATTTA TATTCCTACT TTGCCGAAAG
    GTTTTTGTAG TATGAGGGGG TGCTGAATTT TGTCAAACAC
    TTTTTCGGTA ATAATTGAGA TGATTGGTTC TGCAGTCATC
    GAGATGTGGA TTTTCTCCTT TATTCTGTTC GTGAGTGATT
    ACACTGGTTG ACTAATGTTA AAACAACCTT ACTTTCCAGG
    AATAAACCCT ATTATCTTTT TTATACA
    PSMC4 NM_153001.2 TGCGGGTACG GACAGCGCAT GAGCTTATGT TGAGGGCGGA 41
    GCCCAGACCA GCCCTTCGTC CTATCCTGCC CTTCCAGCAC
    CTCTCAGCCG TAACTTAAAC TACACTTCCC AGAAGCCTCC
    TCAGCCAGGG ACTTCCGTTG TCGTCAGCGG AAGCGGTGAC
    AGATCATCCC AGGCCACACA GAGGCCGGCT TGGTCACTAT
    GGAGGAGATA GGCATCTTGG TGGAGAAGGC TCAGGATGAG
    ATCCCAGCAC TGTCCGTGTC CCGGCCCCAG ACCGGCCTGT
    CCTTCCTGGG CCCTGAGCCT GAGGACCTGG AGGACCTGTA
    CAGCCGCTAC AAGGAGGAGG TGAAGCGAAT CCAAAGCATC
    CCGCTGGTCA TCGGACAATT TCTGGAGGCT GTGGATCAGA
    ATACAGCCAT CGTGGGCTCT ACCACAGGCT CCAACTATTA
    TGTGCGCATC CTGAGCACCA TCGATCGGGA GCTGCTCAAG
    CCCAACGCCT CAGTGGCCCT CCACAAGCAC AGCAATGCAC
    TGGTGGACGT GCTGCCCCCC GAAGCCGACA GCAGCATCAT
    GATGCTCACC TCAGACCAGA AGCCAGATGT GATGTACGCG
    GACATCGGAG GCATGGACAT CCAGAAGCAG GAGGTGCGGG
    AGGCCGTGGA GCTCCCGCTC ACGCATTTCG AGCTCTACAA
    GCAGATCGGC ATCGATCCCC CCCGAGGCGT CCTCATGTAT
    GGCCCACCTG GCTGTGGGAA GACCATGTTG GCAAAGGCGG
    TGGCACATCA CACAACAGCT GCATTCATCC GGGTCGTGGG
    CTCGGAGTTT GTACAGAAGT ATCTGGGTGA GGGCCCCCGC
    ATGGTCCGGG ATGTGTTCCG CCTGGCCAAG GAGAATGCAC
    CTGCCATCAT CTTCATAGAC GAGATTGATG CCATCGCCAC
    CAAGAGATTC GATGCTCAGA CAGGGGCCGA CAGGGAGGTT
    CAGAGGATCC TGCTGGAGCT GCTGAATCAG ATGGATGGAT
    TTGATCAGAA TGTCAATGTC AAGGTAATCA TGGCCACAAA
    CAGAGCAGAC ACCCTGGATC CGGCCCTGCT ACGGCCAGGA
    CGGCTGGACC GTAAAATTGA ATTTCCACTT CCTGACCGCC
    GCCAGAAGAG ATTGATTTTC TCCACTATCA CTAGCAAGAT
    GAACCTCTCT GAGGAGGTTG ACTTGGAAGA CTATGTGGCC
    CGGCCAGATA AGATTTCAGG AGCTGATATT AACTCCATCT
    GTCAGGAGAG TGGAATGTTG GCTGTCCGTG AAAACCGCTA
    CATTGTCCTG GCCAAGGACT TCGAGAAAGC ATACAAGACT
    GTCATCAAGA AGGACGAGCA GGAGCATGAG TTTTACAAGT
    GACCCTTCCC TTCCCTCCAC CACACCACTC AGGGGCTGGG
    GCTTCTCTCG CACCCCCAGC ACCTCTGTCC CAAAACCTCA
    TTCCCTTTTT TCTTTACCCA GGATTGGTTT CTTCAATAAA
    TAGATAAGAT CGAATCCATT TAATTTCTTC TTAGAAGTTT
    AACTCCTTTG GAGAATGTGG GCCTTGAATA GGATCCTCTG
    GGTCCCTCTT AATCTGACAG ATGAGCAGAC GAGGTGCATG
    GCCTGGGTTG CAGCTTGAGA GAACCAAAAT ATTCAAACCA
    GATGACTTCC AAAATGTGGG GAAAGGGATG GAAAATGAAC
    CTGAGATGGA GTCCTTAATC ACGGGATAAA GCCCTGTGCA
    TCTCCCTCAT TTCCTACAGG TAAAAGACAG TAAAGAAATT
    CAGGTCACAG GCCTTGGGAG TTCATAGGAA GGAGATGTCC
    AGTGCTGTCC AGTAGAACTT T
    SF3A1 NM_005877.5 GGTCCCGGAA GTGCGCCAGT CGTACCTTCG CGGCCGCAAC 42
    TCGCTCGGCC GCCGCCATCT TGCGAGCTCG TCGTACTGAC
    CGAGCGGGGA GGCTGTCTTG AGGCGGCACC GCTCACCGAC
    ACCGAGGCGG ACTGGCAGCC CTGAGCGTCG CAGTCATGCC
    GGCCGGACCC GTGCAGGCGG TGCCCCCGCC GCCGCCCGTG
    CCCACGGAGC CCAAACAGCC CACAGAAGAA GAAGCATCTT
    CAAAGGAGGA TTCTGCACCT TCTAAGCCAG TTGTGGGGAT
    TATTTACCCT CCTCCAGAGG TCAGAAATAT TGTTGACAAG
    ACTGCCAGCT TTGTGGCCAG AAACGGGCCT GAATTTGAAG
    CTAGGATCCG ACAGAACGAG ATCAACAACC CCAAGTTCAA
    CTTTCTGAAC CCCAATGACC CTTACCATGC CTACTACCGC
    CACAAGGTCA GCGAGTTCAA GGAAGGGAAG GCTCAGGAGC
    CGTCCGCCGC CATCCCCAAG GTCATGCAGC AGCAGCAGCA
    GACCACCCAG CAGCAGCTGC CCCAGAAGGT CCAAGCCCAA
    GTAATCCAAG AGACCATCGT GCCCAAAGAG CCTCCTCCTG
    AGTTTGAGTT CATTGCTGAT CCTCCCTCTA TCTCAGCCTT
    CGACTTGGAT GTGGTGAAGC TGACGGCTCA GTTTGTGGCC
    AGGAATGGGC GCCAGTTTCT GACCCAGCTG ATGCAGAAAG
    AGCAGCGCAA CTACCAGTTT GACTTTCTCC GCCCACAGCA
    CAGCCTCTTC AACTACTTCA CGAAGCTAGT GGAACAGTAC
    ACCAAGATCT TGATTCCACC CAAAGGTTTA TTTTCAAAGC
    TCAAGAAAGA GGCTGAAAAC CCCCGAGAAG TTTTGGATCA
    GGTGTGTTAC CGAGTGGAAT GGGCCAAATT CCAGGAACGT
    GAGAGGAAGA AGGAAGAAGA GGAGAAGGAG AAGGAGCGGG
    TGGCCTATGC TCAGATCGAC TGGCATGATT TTGTGGTGGT
    GGAAACAGTG GACTTCCAAC CCAATGAGCA AGGGAACTTC
    CCTCCCCCCA CCACGCCAGA GGAGCTGGGG GCCCGAATCC
    TCATTCAGGA GCGCTATGAA AAGTTTGGGG AGAGTGAGGA
    AGTTGAGATG GAGGTCGAGT CTGATGAGGA GGATGACAAA
    CAGGAGAAGG CGGAGGAGCC TCCTTCCCAG CTGGACCAGG
    ACACCCAAGT ACAAGATATG GATGAGGGTT CAGATGATGA
    AGAAGAAGGG CAGAAAGTGC CCCCACCCCC AGAGACACCC
    ATGCCTCCAC CTCTGCCCCC AACTCCAGAC CAAGTCATTG
    TCCGCAAGGA TTATGATCCC AAAGCCTCCA AGCCCTTGCC
    TCCAGCCCCT GCTCCAGATG AGTATCTTGT GTCCCCCATT
    ACTGGGGAGA AGATCCCCGC CAGCAAAATG CAGGAACACA
    TGCGCATTGG ACTTCTTGAC CCTCGCTGGC TGGAGCAGCG
    GGATCGCTCC ATCCGTGAGA AGCAGAGCGA TGATGAGGTG
    TACGCACCAG GTCTGGATAT TGAGAGCAGC TTGAAGCAGT
    TGGCTGAGCG GCGTACTGAC ATCTTCGGTG TAGAGGAAAC
    AGCCATTGGT AAGAAGATCG GTGAGGAGGA GATCCAGAAG
    CCAGAGGAAA AGGTGACCTG GGATGGCCAC TCAGGCAGCA
    TGGCCCGGAC CCAGCAGGCT GCCCAGGCCA ACATCACCCT
    CCAGGAGCAG ATTGAGGCCA TTCACAAGGC CAAAGGCCTG
    GTGCCAGAGG ATGACACTAA AGAGAAGATT GGCCCCAGCA
    AGCCCAATGA AATCCCTCAA CAGCCACCGC CACCATCTTC
    AGCCACCAAC ATCCCCAGCT CGGCTCCACC CATCACTTCA
    GTGCCCCGAC CACCCACAAT GCCACCTCCA GTTCGTACTA
    CAGTTGTCTC CGCAGTACCC GTCATGCCCC GGCCCCCAAT
    GGCATCTGTG GTCCGGCTGC CCCCAGGCTC AGTGATCGCC
    CCCATGCCGC CCATCATCCA CGCGCCCAGA ATCAACGTGG
    TGCCCATGCC TCCCTCGGCC CCTCCTATTA TGGCCCCCCG
    CCCACCCCCC ATGATTGTGC CAACAGCCTT TGTGCCTGCT
    CCACCTGTGG CACCTGTCCC AGCTCCAGCC CCAATGCCCC
    CTGTGCATCC CCCACCTCCC ATGGAAGATG AGCCCACCTC
    CAAAAAACTG AAGACAGAGG ACAGCCTCAT GCCAGAGGAG
    GAGTTCCTGC GCAGAAACAA GGGTCCAGTG TCCATCAAAG
    TCCAGGTGCC CAACATGCAG GATAAGACGG AATGGAAACT
    GAATGGGCAG GTGCTGGTCT TCACCCTCCC ACTCACGGAC
    CAGGTCTCTG TCATTAAGGT GAAGATTCAT GAAGCCACAG
    GCATGCCTGC AGGGAAACAG AAGCTACAGT ATGAGGGTAT
    CTTCATCAAA GATTCCAACT CACTGGCTTA CTACAACATG
    GCCAATGGCG CAGTCATCCA CCTGGCCCTC AAGGAGAGAG
    GCGGGAGGAA GAAGTAGACA AGAGGAACCT GCTGTCAAGT
    CCCTGCCATT TTGCCTCTCC TGTCTCCCAC CCCCTGCCCC
    AGACCCAGGA GCCCCCCTGA GGCTTTGCCT TGCCTGCATA
    TTTGTTTCGC TCTTACTCAG TTTGGGAATT CAAATTGTCC
    TGCAGAGGTT CATTCCCCTG ACCCTTTCCC CACATTGGTA
    AGAGTAGCTG GGTTTTCTAA GCCACTCTCT GGAATCTCTT
    TGTGTTAGGG TCTCGATTTG AGGACATTCA TTTCTTCAGC
    AGCCCATTAG CAACTGAGAG CCCAGGGATG TCCTACAGGA
    TAGTTTCATA GTGACAGGTG GCACTTGGCT AATAGAATAT
    GGCTGATATT GTCATTAATC ATTTTGTACC TTGACATGGG
    TTGTCTAATA AAACTCGGAC CCTTCTTGTG AAATCAGTTA
    AATAAGACTT GTCTCGGTCA CCTGTGCCCT GTCCAGACTC
    GAGGCAGTGG TAACACTGCA CAGTGCTATG TGGCTTCTCT
    TTGAGGATTT TTGGGTTTTG TAACTAAATT CTTGCTGCCC
    TCATACTTTT TATGTATTAG AATCATATTC GTATTGCCCT
    TTTAAAACAT TGGGATCCTC CAAAGGCCTG CCCCATGTAT
    TTAACAGTAA TACAGGAAGC ATGGCAGGCA CCATGCAAAC
    CAAGGATGGA TGGTGCAGTC CCTGTGTCAG TGGGCGGTGG
    TTTCCTGCTG GCCTGGAATC ACTCATCACC TGATTGATTG
    GCTCTGTGGT CCTGGGCAGG TGCCTCATAG GTGTGTGGAT
    ATGATGACGT TTCTTTAAAA TGTATGTATT TAACAAATAC
    TTAATTGTAT TAAGGTCATG TACCAAGGAT TTGATAAAGT
    TTAAATAATT TACTCTCTAC TTTTATCCAT TTTATCCATT
    TTAACTCATG TAATCCTCAT GTGAGTATTC CTGTTTAACA
    CTTGAGTAAA CTGAGGCACA GAGAACATAA GTTGCATGCC
    ATAGTCACAC ACTGTGAAAG TGAAAAGAGA ATGTGTGCAA
    AACACGTCAC AGTCCTGGTT TCTGAGTAAA GGCAGGCTGT
    TATCTTTAGA ATCAAGCTAT CACAGGGAGA TAGGCAATGC
    TGTGGGTGTT GGAGGAAGGT GAGAGCCTGT TGCTAACAAT
    TTCCTGGTTT TAAAGCTAAG GCTGATTTTA TTGGGAAGAT
    CTCACATGTG TGTGGCCCCT GAGAGTTCCC AGTGCCTTTT
    ATTTGCAGTC CTTCCATTTG GACCTCCTAG CTGCCCCATC
    AGGTCATCTC CAGGGCTCAG AGGGGTGAGA CCATTTCCCA
    AGGTCACAGA ACCAGCTCTC TAGTCACCAC CCTGCCTCTC
    CCTCTCACCC AGAGTCAGTA CCAGTTTTAT GGCTTTATTA
    CAAACTGCTG GGTCCCTCCC ATTTTCAACT TGATTGATGG
    GATGTCATCC CTTATCCTGT CTGACATTTG CCTCTGGCCT
    GGTTGCTAGA AGTTTGCCCC AGGGGCAAGA GTTGAAATTT
    GGCTTCCTGA GGTGGGCTTT GTGGTTTGCG TCCCTAAAGT
    GAGCCCACTA CTGGTTGCTT GTCCATGGCC AACACCAGAA
    ATCCCCTGAG CACTACCTGG GTCTCATTCC AAGAAGGAAG
    AGGGTCAGGA GACCTGGGGA GTCTCATATT CCAAGTTCTT
    CTTTCTTTCT GGGAGCAGTG GGCAGTTCAT GGTGTTAGGG
    CACTCACCCC CACAGACTGG CAAACCCTGC AGGACTTCCG
    TGGCTGAGGC TGTGACCGGA GGCCAGGAAT GCCGTTGGGT
    GGATTGTGAG TGAATGGGCC CTTTGAGCTG CCCTCTAGAG
    AGCAAATCCA GTTTCCTGGA GCTCCTGAAT GAATATCTGT
    ACTGGCTCGC TCAGATGCAG AAGCTCCATT GACCATGAGG
    CCTTGTGAAC ATCAGTGGCC ACAGGCCCAG TGTGCTGCTT
    GGCACTGCAC TAGTTTAGGA CCTGCAGCAT GTAGGTAGCG
    TCCTAGTGTT TATAATACAA AGCTGCTCTG CACAGCTTTT
    CTGATTCTTC TTGCAATCTC CTGAGGATTA TCTGCCCCAT
    TTTTAAAACG AGGTGGAATA CCCAAGGTCA TGTAGCCAGT
    GAGTGCTCTG GAAAGCCAAA GCAGCTCATC CCTTCCTGGG
    GACCACACTG CTCTGCTCCA CCAGACCACA CTATGAAATA
    GGAATAAGTG CTCCTGTTGC AGGACTGCTG GGAAAACAGG
    TGGTGTGGGA CTTAAGTCAC CATAATTTTG AAGACTTGCA
    TGCAGAGGGC TCCAGGAATT GTAGACATTA AGGAATTTCA
    CTTTCAGTTC TACCCACTAC TTAAGTACTT GTCATGTACT
    CTTAGAGGAG GCCAGTAATG ATCAGAACCA TTTTACTTTA
    AAATTAATAA TATTGTATTA GAGAATATAT TAAATGGTTA
    TATTGGGTTA TGTTAGGATA TATACTTGAA TGGAAATACA
    TGTACTATTA GCAATCATAT TTCATTTATC CCTGTAATTA
    GACAAGAAAG CATAATATAG CTCTACTCAT GGGTACACAT
    ACCAGTGTAT AAGATTTTTA GAAGTTTACT TTTTAAAAAT
    AAAAGCAAAA TGTAAGATCT TAAAAAAAAA AAAAAAAAA
    PUM1 NM_001020658.1 AGTGGGCCGC CATGTTGTCG GAGTGAAAGG TAAGGGGGAG 43
    CGAGAGCGCC AGAGAGAGAA GATCGGGGGG CTGAAATCCA
    TCTTCATCCT ACCGCTCCGC CCGTGTTGGT GGAATGAGCG
    TTGCATGTGT CTTGAAGAGA AAAGCAGTGC TTTGGCAGGA
    CTCTTTCAGC CCCCACCTGA AACATCACCC TCAAGAACCA
    GCTAATCCCA ACATGCCTGT TGTTTTGACA TCTGGAACAG
    GGTCGCAAGC GCAGCCACAA CCAGCTGCAA ATCAGGCTCT
    TGCAGCTGGG ACTCACTCCA GCCCTGTCCC AGGATCTATA
    GGAGTTGCAG GCCGTTCCCA GGACGACGCT ATGGTGGACT
    ACTTCTTTCA GAGGCAGCAT GGTGAGCAGC TTGGGGGAGG
    AGGAAGTGGA GGAGGCGGCT ATAATAATAG CAAACATCGA
    TGGCCTACTG GGGATAACAT TCATGCAGAA CATCAGGTGC
    GTTCCATGGA TGAACTGAAT CATGATTTTC AAGCACTTGC
    TCTGGAGGGA AGAGCGATGG GAGAGCAGCT CTTGCCAGGT
    AAAAAGTTTT GGGAAACAGA TGAATCCAGC AAAGATGGAC
    CAAAAGGAAT ATTCCTGGGT GATCAATGGC GAGACAGTGC
    CTGGGGAACA TCAGATCATT CAGTTTCCCA GCCAATCATG
    GTGCAGAGAA GACCTGGTCA GAGTTTCCAT GTGAACAGTG
    AGGTCAATTC TGTACTGTCC CCACGATCGG AGAGTGGGGG
    ACTAGGCGTT AGCATGGTGG AGTATGTGTT GAGCTCATCC
    CCGGGCGATT CCTGTCTAAG AAAAGGAGGA TTTGGCCCAA
    GGGATGCAGA CAGTGATGAA AACGACAAAG GTGAAAAGAA
    GAACAAGGGT ACGTTTGATG GAGATAAGCT AGGAGATTTG
    AAGGAGGAGG GTGATGTGAT GGACAAGACC AATGGTTTAC
    CAGTGCAGAA TGGGATTGAT GCAGACGTCA AAGATTTTAG
    CCGTACCCCT GGTAATTGCC AGAACTCTGC TAATGAAGTG
    GATCTTCTGG GTCCAAACCA GAATGGTTCT GAGGGCTTAG
    CCCAGCTGAC CAGCACCAAT GGTGCCAAGC CTGTGGAGGA
    TTTCTCCAAC ATGGAGTCCC AGAGTGTCCC CTTGGACCCC
    ATGGAACATG TGGGCATGGA GCCTCTTCAG TTTGATTATT
    CAGGCACGCA GGTACCTGTG GACTCAGCAG CAGCAACTGT
    GGGACTTTTT GACTACAATT CTCAACAACA GCTGTTCCAA
    AGACCTAATG CGCTTGCTGT CCAGCAGTTG ACAGCTGCTC
    AGCAGCAGCA GTATGCACTG GCAGCTGCTC ATCAGCCGCA
    CATCGGTTTA GCTCCCGCTG CGTTTGTCCC CAATCCATAC
    ATCATCAGCG CTGCTCCCCC AGGGACGGAC CCCTACACAG
    CTGGATTGGC TGCAGCAGCG ACACTAGGCC CAGCTGTGGT
    CCCTCACCAG TATTATGGAG TTACTCCCTG GGGAGTCTAC
    CCTGCCAGTC TTTTCCAGCA GCAAGCTGCC GCTGCCGCTG
    CAGCAACTAA TTCAGCTAAT CAACAGACCA CCCCACAGGC
    TCAGCAAGGA CAGCAGCAGG TTCTCCGTGG AGGAGCCAGC
    CAACGTCCTT TGACCCCAAA CCAGAACCAG CAGGGACAGC
    AAACGGATCC CCTTGTGGCA GCTGCAGCAG TGAATTCTGC
    CCTTGCATTT GGACAAGGTC TGGCAGCAGG CATGCCAGGT
    TATCCGGTGT TGGCTCCTGC TGCTTACTAT GACCAAACTG
    GTGCCCTTGT AGTGAATGCA GGCGCGAGAA ATGGTCTTGG
    AGCTCCTGTT CGACTTGTAG CTCCTGCCCC AGTCATCATT
    AGTTCCTCAG CTGCACAAGC AGCTGTTGCA GCAGCCGCAG
    CTTCAGCAAA TGGAGCAGCT GGTGGTCTTG CTGGAACAAC
    AAATGGACCA TTTCGCCCTT TAGGAACACA GCAGCCTCAG
    CCCCAGCCCC AGCAGCAGCC CAATAACAAC CTGGCATCCA
    GTTCTTTCTA CGGCAACAAC TCTCTGAACA GCAATTCACA
    GAGCAGCTCC CTCTTCTCCC AGGGCTCTGC CCAGCCTGCC
    AACACATCCT TGGGATTCGG AAGTAGCAGT TCTCTCGGCG
    CCACCCTGGG ATCCGCCCTT GGAGGGTTTG GAACAGCAGT
    TGCAAACTCC AACACTGGCA GTGGCTCCCG CCGTGACTCC
    CTGACTGGCA GCAGTGACCT TTATAAGAGG ACATCGAGCA
    GCTTGACCCC CATTGGACAC AGTTTTTATA ACGGCCTTAG
    CTTTTCCTCC TCTCCTGGAC CCGTGGGCAT GCCTCTCCCT
    AGTCAGGGAC CAGGACATTC ACAGACACCA CCTCCTTCCC
    TCTCTTCACA TGGATCCTCT TCAAGCTTAA ACCTGGGAGG
    ACTCACGAAT GGCAGTGGAA GATACATCTC TGCTGCTCCA
    GGCGCTGAAG CCAAGTACCG CAGTGCAAGC AGCGCCTCCA
    GCCTCTTCAG CCCGAGCAGC ACTCTTTTCT CTTCCTCTCG
    TTTGCGATAT GGAATGTCTG ATGTCATGCC TTCTGGCAGG
    AGCAGGCTTT TGGAAGATTT TCGAAACAAC CGGTACCCCA
    ATTTACAACT GCGGGAGATT GCTGGACATA TAATGGAATT
    TTCCCAAGAC CAGCATGGGT CCAGATTCAT TCAGCTGAAA
    CTGGAGCGTG CCACACCAGC TGAGCGCCAG CTTGTCTTCA
    ATGAAATCCT CCAGGCTGCC TACCAACTCA TGGTGGATGT
    GTTTGGTAAT TACGTCATTC AGAAGTTCTT TGAATTTGGC
    AGTCTTGAAC AGAAGCTGGC TTTGGCAGAA CGGATTCGAG
    GCCACGTCCT GTCATTGGCA CTACAGATGT ATGGCTGCCG
    TGTTATCCAG AAAGCTCTTG AGTTTATTCC TTCAGACCAG
    CAGGTAATTA ATGAGATGGT TCGGGAACTA GATGGCCATG
    TCTTGAAGTG TGTGAAAGAT CAGAATGGCA ATCACGTGGT
    TCAGAAATGC ATTGAATGTG TACAGCCCCA GTCTTTGCAA
    TTTATCATCG ATGCGTTTAA GGGACAGGTA TTTGCCTTAT
    CCACACATCC TTATGGCTGC CGAGTGATTC AGAGAATCCT
    GGAGCACTGT CTCCCTGACC AGACACTCCC TATTTTAGAG
    GAGCTTCACC AGCACACAGA GCAGCTTGTA CAGGATCAAT
    ATGGAAATTA TGTAATCCAA CATGTACTGG AGCACGGTCG
    TCCTGAGGAT AAAAGCAAAA TTGTAGCAGA AATCCGAGGC
    AATGTACTTG TATTGAGTCA GCACAAATTT GCAAGCAATG
    TTGTGGAGAA GTGTGTTACT CACGCCTCAC GTACGGAGCG
    CGCTGTGCTC ATCGATGAGG TGTGCACCAT GAACGACGGT
    CCCCACAGTG CCTTATACAC CATGATGAAG GACCAGTATG
    CCAACTACGT GGTCCAGAAG ATGATTGACG TGGCGGAGCC
    AGGCCAGCGG AAGATCGTCA TGCATAAGAT CCGGCCCCAC
    ATCGCAACTC TTCGTAAGTA CACCTATGGC AAGCACATTC
    TGGCCAAGCT GGAGAAGTAC TACATGAAGA ACGGTGTTGA
    CTTAGGGCCC ATCTGTGGCC CCCCTAATGG TATCATCTGA
    GGCAGTGTCA CCCGCTGTTC CCTCATTCCC GCTGACCTCA
    CTGGCCCACT GGCAAATCCA ACCAGCAACC AGAAATGTTC
    TAGTGTAGAG TCTGAGACGG GCAAGTGGTT GCTCCAGGAT
    TACTCCCTCC TCCAAAAAAG GAATCAAATC CACGAGTGGA
    AAAGCCTTTG TAAATTTAAT TTTATTACAC ATAACATGTA
    CTATTTTTTT TAATTGACTA ATTGCCCTGC TGTTTTACTG
    GTGTATAGGA TACTTGTACA TAGGTAACCA ATGTACATGG
    GAGGCCACAT ATTTTGTTCA CTGTTGTATC TATATTTCAC
    ATGTGGAAAC TTTCAGGGTG GTTGGTTTAA CAAAAAAAAA
    AAGCTTTAAA AAAAAAAGAA AAAAAGGAAA AGGTTTTTAG
    CTCATTTGCC TGGCCGGCAA GTTTTGCAAA TAGCTCTTCC
    CCACCTCCTC ATTTTAGTAA AAAACAAACA AAAACAAAAA
    AACCTGAGAA GTTTGAATTG TAGTTAAATG ACCCCAAACT
    GGCATTTAAC ACTGTTTATA AAAAATATAT ATATATATAT
    ATATATATAT AATGAAAAAG GTTTCAGAGT TGCTAAAGCT
    TCAGTTTGTG ACATTAAGTT TATGAAATTC TAAAAAATGC
    CTTTTTTGGA GACTATATTA TGCTGAAGAA GGCTGTTCGT
    GAGGAGGAGA TGCGAGCACC CAGAACGTCT TTTGAGGCTG
    GGCGGGTGTG ATTGTTTACT GCCTACTGGA TTTTTTTCTA
    TTAACATTGA AAGGTAAAAT CTGATTATTT AGCATGAGAA
    AAAAAAATCC AACTCTGCTT TTGGTCTTGC TTCTATAAAT
    ATATAGTGTA TACTTGGTGT AGACTTTGCA TATATACAAA
    TTTGTAGTAT TTTCTTGTTT TGATGTCTAA TCTGTATCTA
    TAATGTACCC TAGTAGTCGA ACATACTTTT GATTGTACAA
    TTGTACATTT GTATACCTGT AATGTAAATG TGGAGAAGTT
    TGAATCAACA TAAACACGTT TTTTGGTAAG AAAAGAGAAT
    TAGCCAGCCC TGTGCATTCA GTGTATATTC TCACCTTTTA
    TGGTCGTAGC ATATAGTGTT GTATATTGTA AATTGTAATT
    TCAACCAGAA GTAAATTTTT TTCTTTTGAA GGAATAAATG
    TTCTTTATAC AGCCTAGTTA ATGTTTAAAA AGAAAAAAAT
    AGCTTGGTTT TATTTGTCAT CTAGTCTCAA GTATAGCGAG
    ATTCTTTCTA AATGTTATTC AAGATTGAGT TCTCACTAGT
    GTTTTTTTAA TCCTAAAAAA GTAATGTTTT GATTTTGTGA
    CAGTCAAAAG GACGTGCAAA AGTCTAGCCT TGCCCGAGCT
    TTCCTTACAA TCAGAGCCCC TCTCACCTTG TAAAGTGTGA
    ATCGCCCTTC CCTTTTGTAC AGAAGATGAA CTGTATTTTG
    CATTTTGTCT ACTTGTAAGT GAATGTAACA TACTGTCAAT
    TTTCCTTGTT TGAATATAGA ATTGTAACAC TACACGGTGT
    ACATTTCCAG AGCCTTGTGT ATATTTCCAA TGAACTTTTT
    TGCAAGCACA CTTGTAACCA TATGTGTATA ATTAACAAAC
    CTGTGTATGC TTATGCCTGG GCAACTATTT TTTGTAACTC
    TTGTGTAGAT TGTCTCTAAA CAATGTGTGA TCTTTATTTT
    GAAAAATACA GAACTTTGGA ATCTGAAAAA AAAAAAAAAA
    AAAAAAAAAA AAAAAA
    ACTB NM_001101.4 GAGTGAGCGG CGCGGGGCCA ATCAGCGTGC GCCGTTCCGA 44
    AAGTTGCCTT TTATGGCTCG AGCGGCCGCG GCGGCGCCCT
    ATAAAACCCA GCGGCGCGAC GCGCCACCAC CGCCGAGACC
    GCGTCCGCCC CGCGAGCACA GAGCCTCGCC TTTGCCGATC
    CGCCGCCCGT CCACACCCGC CGCCAGCTCA CCATGGATGA
    TGATATCGCC GCGCTCGTCG TCGACAACGG CTCCGGCATG
    TGCAAGGCCG GCTTCGCGGG CGACGATGCC CCCCGGGCCG
    TCTTCCCCTC CATCGTGGGG CGCCCCAGGC ACCAGGGCGT
    GATGGTGGGC ATGGGTCAGA AGGATTCCTA TGTGGGCGAC
    GAGGCCCAGA GCAAGAGAGG CATCCTCACC CTGAAGTACC
    CCATCGAGCA CGGCATCGTC ACCAACTGGG ACGACATGGA
    GAAAATCTGG CACCACACCT TCTACAATGA GCTGCGTGTG
    GCTCCCGAGG AGCACCCCGT GCTGCTGACC GAGGCCCCCC
    TGAACCCCAA GGCCAACCGC GAGAAGATGA CCCAGATCAT
    GTTTGAGACC TTCAACACCC CAGCCATGTA CGTTGCTATC
    CAGGCTGTGC TATCCCTGTA CGCCTCTGGC CGTACCACTG
    GCATCGTGAT GGACTCCGGT GACGGGGTCA CCCACACTGT
    GCCCATCTAC GAGGGGTATG CCCTCCCCCA TGCCATCCTG
    CGTCTGGACC TGGCTGGCCG GGACCTGACT GACTACCTCA
    TGAAGATCCT CACCGAGCGC GGCTACAGCT TCACCACCAC
    GGCCGAGCGG GAAATCGTGC GTGACATTAA GGAGAAGCTG
    TGCTACGTCG CCCTGGACTT CGAGCAAGAG ATGGCCACGG
    CTGCTTCCAG CTCCTCCCTG GAGAAGAGCT ACGAGCTGCC
    TGACGGCCAG GTCATCACCA TTGGCAATGA GCGGTTCCGC
    TGCCCTGAGG CACTCTTCCA GCCTTCCTTC CTGGGCATGG
    AGTCCTGTGG CATCCACGAA ACTACCTTCA ACTCCATCAT
    GAAGTGTGAC GTGGACATCC GCAAAGACCT GTACGCCAAC
    ACAGTGCTGT CTGGCGGCAC CACCATGTAC CCTGGCATTG
    CCGACAGGAT GCAGAAGGAG ATCACTGCCC TGGCACCCAG
    CACAATGAAG ATCAAGATCA TTGCTCCTCC TGAGCGCAAG
    TACTCCGTGT GGATCGGCGG CTCCATCCTG GCCTCGCTGT
    CCACCTTCCA GCAGATGTGG ATCAGCAAGC AGGAGTATGA
    CGAGTCCGGC CCCTCCATCG TCCACCGCAA ATGCTTCTAG
    GCGGACTATG ACTTAGTTGC GTTACACCCT TTCTTGACAA
    AACCTAACTT GCGCAGAAAA CAAGATGAGA TTGGCATGGC
    TTTATTTGTT TTTTTTGTTT TGTTTTGGTT TTTTTTTTTT
    TTTTGGCTTG ACTCAGGATT TAAAAACTGG AACGGTGAAG
    GTGACAGCAG TCGGTTGGAG CGAGCATCCC CCAAAGTTCA
    CAATGTGGCC GAGGACTTTG ATTGCACATT GTTGTTTTTT
    TAATAGTCAT TCCAAATATG AGATGCGTTG TTACAGGAAG
    TCCCTTGCCA TCCTAAAAGC CACCCCACTT CTCTCTAAGG
    AGAATGGCCC AGTCCTCTCC CAAGTCCACA CAGGGGAGGT
    GATAGCATTG CTTTCGTGTA AATTATGTAA TGCAAAATTT
    TTTTAATCTT CGCCTTAATA CTTTTTTATT TTGTTTTATT
    TTGAATGATG AGCCTTCGTG CCCCCCCTTC CCCCTTTTTT
    GTCCCCCAAC TTGAGATGTA TGAAGGCTTT TGGTCTCCCT
    GGGAGTGGGT GGAGGCAGCC AGGGCTTACC TGTACACTGA
    CTTGAGACCA GTTGAATAAA AGTGCACACC TTAAAAATGA
    GGAAAAAAAA AAAAAAAAAA
    GAPD NM_002046.6 GCTCTCTGCT CCTCCTGTTC GACAGTCAGC CGCATCTTCT 45
    TTTGCGTCGC CAGCCGAGCC ACATCGCTCA GACACCATGG
    GGAAGGTGAA GGTCGGAGTC AACGGATTTG GTCGTATTGG
    GCGCCTGGTC ACCAGGGCTG CTTTTAACTC TGGTAAAGTG
    GATATTGTTG CCATCAATGA CCCCTTCATT GACCTCAACT
    ACATGGTTTA CATGTTCCAA TATGATTCCA CCCATGGCAA
    ATTCCATGGC ACCGTCAAGG CTGAGAACGG GAAGCTTGTC
    ATCAATGGAA ATCCCATCAC CATCTTCCAG GAGCGAGATC
    CCTCCAAAAT CAAGTGGGGC GATGCTGGCG CTGAGTACGT
    CGTGGAGTCC ACTGGCGTCT TCACCACCAT GGAGAAGGCT
    GGGGCTCATT TGCAGGGGGG AGCCAAAAGG GTCATCATCT
    CTGCCCCCTC TGCTGATGCC CCCATGTTCG TCATGGGTGT
    GAACCATGAG AAGTATGACA ACAGCCTCAA GATCATCAGC
    AATGCCTCCT GCACCACCAA CTGCTTAGCA CCCCTGGCCA
    AGGTCATCCA TGACAACTTT GGTATCGTGG AAGGACTCAT
    GACCACAGTC CATGCCATCA CTGCCACCCA GAAGACTGTG
    GATGGCCCCT CCGGGAAACT GTGGCGTGAT GGCCGCGGGG
    CTCTCCAGAA CATCATCCCT GCCTCTACTG GCGCTGCCAA
    GGCTGTGGGC AAGGTCATCC CTGAGCTGAA CGGGAAGCTC
    ACTGGCATGG CCTTCCGTGT CCCCACTGCC AACGTGTCAG
    TGGTGGACCT GACCTGCCGT CTAGAAAAAC CTGCCAAATA
    TGATGACATC AAGAAGGTGG TGAAGCAGGC GTCGGAGGGC
    CCCCTCAAGG GCATCCTGGG CTACACTGAG CACCAGGTGG
    TCTCCTCTGA CTTCAACAGC GACACCCACT CCTCCACCTT
    TGACGCTGGG GCTGGCATTG CCCTCAACGA CCACTTTGTC
    AAGCTCATTT CCTGGTATGA CAACGAATTT GGCTACAGCA
    ACAGGGTGGT GGACCTCATG GCCCACATGG CCTCCAAGGA
    GTAAGACCCC TGGACCACCA GCCCCAGCAA GAGCACAAGA
    GGAAGAGAGA GACCCTCACT GCTGGGGAGT CCCTGCCACA
    CTCAGTCCCC CACCACACTG AATCTCCCCT CCTCACAGTT
    GCCATGTAGA CCCCTTGAAG AGGGGAGGGG CCTAGGGAGC
    CGCACCTTGT CATGTACCAT CAATAAAGTA CCCTGTGCTC
    AACCAGTTAA AAAAAAAAAA AAAAAAAAA
    GUSB NM_000181.3 GTCCTCAACC AAGATGGCGC GGATGGCTTC AGGCGCATCA 46
    CGACACCGGC GCGTCACGCG ACCCGCCCTA CGGGCACCTC
    CCGCGCTTTT CTTAGCGCCG CAGACGGTGG CCGAGCGGGG
    GACCGGGAAG CATGGCCCGG GGGTCGGCGG TTGCCTGGGC
    GGCGCTCGGG CCGTTGTTGT GGGGCTGCGC GCTGGGGCTG
    CAGGGCGGGA TGCTGTACCC CCAGGAGAGC CCGTCGCGGG
    AGTGCAAGGA GCTGGACGGC CTCTGGAGCT TCCGCGCCGA
    CTTCTCTGAC AACCGACGCC GGGGCTTCGA GGAGCAGTGG
    TACCGGCGGC CGCTGTGGGA GTCAGGCCCC ACCGTGGACA
    TGCCAGTTCC CTCCAGCTTC AATGACATCA GCCAGGACTG
    GCGTCTGCGG CATTTTGTCG GCTGGGTGTG GTACGAACGG
    GAGGTGATCC TGCCGGAGCG ATGGACCCAG GACCTGCGCA
    CAAGAGTGGT GCTGAGGATT GGCAGTGCCC ATTCCTATGC
    CATCGTGTGG GTGAATGGGG TCGACACGCT AGAGCATGAG
    GGGGGCTACC TCCCCTTCGA GGCCGACATC AGCAACCTGG
    TCCAGGTGGG GCCCCTGCCC TCCCGGCTCC GAATCACTAT
    CGCCATCAAC AACACACTCA CCCCCACCAC CCTGCCACCA
    GGGACCATCC AATACCTGAC TGACACCTCC AAGTATCCCA
    AGGGTTACTT TGTCCAGAAC ACATATTTTG ACTTTTTCAA
    CTACGCTGGA CTGCAGCGGT CTGTACTTCT GTACACGACA
    CCCACCACCT ACATCGATGA CATCACCGTC ACCACCAGCG
    TGGAGCAAGA CAGTGGGCTG GTGAATTACC AGATCTCTGT
    CAAGGGCAGT AACCTGTTCA AGTTGGAAGT GCGTCTTTTG
    GATGCAGAAA ACAAAGTCGT GGCGAATGGG ACTGGGACCC
    AGGGCCAACT TAAGGTGCCA GGTGTCAGCC TCTGGTGGCC
    GTACCTGATG CACGAACGCC CTGCCTATCT GTATTCATTG
    GAGGTGCAGC TGACTGCACA GACGTCACTG GGGCCTGTGT
    CTGACTTCTA CACACTCCCT GTGGGGATCC GCACTGTGGC
    TGTCACCAAG AGCCAGTTCC TCATCAATGG GAAACCTTTC
    TATTTCCACG GTGTCAACAA GCATGAGGAT GCGGACATCC
    GAGGGAAGGG CTTCGACTGG CCGCTGCTGG TGAAGGACTT
    CAACCTGCTT CGCTGGCTTG GTGCCAACGC TTTCCGTACC
    AGCCACTACC CCTATGCAGA GGAAGTGATG CAGATGTGTG
    ACCGCTATGG GATTGTGGTC ATCGATGAGT GTCCCGGCGT
    GGGCCTGGCG CTGCCGCAGT TCTTCAACAA CGTTTCTCTG
    CATCACCACA TGCAGGTGAT GGAAGAAGTG GTGCGTAGGG
    ACAAGAACCA CCCCGCGGTC GTGATGTGGT CTGTGGCCAA
    CGAGCCTGCG TCCCACCTAG AATCTGCTGG CTACTACTTG
    AAGATGGTGA TCGCTCACAC CAAATCCTTG GACCCCTCCC
    GGCCTGTGAC CTTTGTGAGC AACTCTAACT ATGCAGCAGA
    CAAGGGGGCT CCGTATGTGG ATGTGATCTG TTTGAACAGC
    TACTACTCTT GGTATCACGA CTACGGGCAC CTGGAGTTGA
    TTCAGCTGCA GCTGGCCACC CAGTTTGAGA ACTGGTATAA
    GAAGTATCAG AAGCCCATTA TTCAGAGCGA GTATGGAGCA
    GAAACGATTG CAGGGTTTCA CCAGGATCCA CCTCTGATGT
    TCACTGAAGA GTACCAGAAA AGTCTGCTAG AGCAGTACCA
    TCTGGGTCTG GATCAAAAAC GCAGAAAATA CGTGGTTGGA
    GAGCTCATTT GGAATTTTGC CGATTTCATG ACTGAACAGT
    CACCGACGAG AGTGCTGGGG AATAAAAAGG GGATCTTCAC
    TCGGCAGAGA CAACCAAAAA GTGCAGCGTT CCTTTTGCGA
    GAGAGATACT GGAAGATTGC CAATGAAACC AGGTATCCCC
    ACTCAGTAGC CAAGTCACAA TGTTTGGAAA ACAGCCTGTT
    TACTTGAGCA AGACTGATAC CACCTGCGTG TCCCTTCCTC
    CCCGAGTCAG GGCGACTTCC ACAGCAGCAG AACAAGTGCC
    TCCTGGACTG TTCACGGCAG ACCAGAACGT TTCTGGCCTG
    GGTTTTGTGG TCATCTATTC TAGCAGGGAA CACTAAAGGT
    GGAAATAAAA GATTTTCTAT TATGGAAATA AAGAGTTGGC
    ATGAAAGTGG CTACTGAAAA AAAAAAAAAA AAAAAAAAAA A
    RPLP0 NM_001002.3 GTCTGACGGG CGATGGCGCA GCCAATAGAC AGGAGCGCTA 47
    TCCGCGGTTT CTGATTGGCT ACTTTGTTCG CATTATAAAA
    GGCACGCGCG GGCGCGAGGC CCTTCTCTCG CCAGGCGTCC
    TCGTGGAAGT GACATCGTCT TTAAACCCTG CGTGGCAATC
    CCTGACGCAC CGCCGTGATG CCCAGGGAAG ACAGGGCGAC
    CTGGAAGTCC AACTACTTCC TTAAGATCAT CCAACTATTG
    GATGATTATC CGAAATGTTT CATTGTGGGA GCAGACAATG
    TGGGCTCCAA GCAGATGCAG CAGATCCGCA TGTCCCTTCG
    CGGGAAGGCT GTGGTGCTGA TGGGCAAGAA CACCATGATG
    CGCAAGGCCA TCCGAGGGCA CCTGGAAAAC AACCCAGCTC
    TGGAGAAACT GCTGCCTCAT ATCCGGGGGA ATGTGGGCTT
    TGTGTTCACC AAGGAGGACC TCACTGAGAT CAGGGACATG
    TTGCTGGCCA ATAAGGTGCC AGCTGCTGCC CGTGCTGGTG
    CCATTGCCCC ATGTGAAGTC ACTGTGCCAG CCCAGAACAC
    TGGTCTCGGG CCCGAGAAGA CCTCCTTTTT CCAGGCTTTA
    GGTATCACCA CTAAAATCTC CAGGGGCACC ATTGAAATCC
    TGAGTGATGT GCAGCTGATC AAGACTGGAG ACAAAGTGGG
    AGCCAGCGAA GCCACGCTGC TGAACATGCT CAACATCTCC
    CCCTTCTCCT TTGGGCTGGT CATCCAGCAG GTGTTCGACA
    ATGGCAGCAT CTACAACCCT GAAGTGCTTG ATATCACAGA
    GGAAACTCTG CATTCTCGCT TCCTGGAGGG TGTCCGCAAT
    GTTGCCAGTG TCTGTCTGCA GATTGGCTAC CCAACTGTTG
    CATCAGTACC CCATTCTATC ATCAACGGGT ACAAACGAGT
    CCTGGCCTTG TCTGTGGAGA CGGATTACAC CTTCCCACTT
    GCTGAAAAGG TCAAGGCCTT CTTGGCTGAT CCATCTGCCT
    TTGTGGCTGC TGCCCCTGTG GCTGCTGCCA CCACAGCTGC
    TCCTGCTGCT GCTGCAGCCC CAGCTAAGGT TGAAGCCAAG
    GAAGAGTCGG AGGAGTCGGA CGAGGATATG GGATTTGGTC
    TCTTTGACTA ATCACCAAAA AGCAACCAAC TTAGCCAGTT
    TTATTTGCAA AACAAGGAAA TAAAGGCTTA CTTCTTTAAA
    AAGTAAAAAA AAAAAAAAAA AAAAAAAAA
    TFRC NM_003234.3 AGAGCGTCGG GATATCGGGT GGCGGCTCGG GACGGAGGAC 48
    GCGCTAGTGT GAGTGCGGGC TTCTAGAACT ACACCGACCC
    TCGTGTCCTC CCTTCATCCT GCGGGGCTGG CTGGAGCGGC
    CGCTCCGGTG CTGTCCAGCA GCCATAGGGA GCCGCACGGG
    GAGCGGGAAA GCGGTCGCGG CCCCAGGCGG GGCGGCCGGG
    ATGGAGCGGG GCCGCGAGCC TGTGGGGAAG GGGCTGTGGC
    GGCGCCTCGA GCGGCTGCAG GTTCTTCTGT GTGGCAGTTC
    AGAATGATGG ATCAAGCTAG ATCAGCATTC TCTAACTTGT
    TTGGTGGAGA ACCATTGTCA TATACCCGGT TCAGCCTGGC
    TCGGCAAGTA GATGGCGATA ACAGTCATGT GGAGATGAAA
    CTTGCTGTAG ATGAAGAAGA AAATGCTGAC AATAACACAA
    AGGCCAATGT CACAAAACCA AAAAGGTGTA GTGGAAGTAT
    CTGCTATGGG ACTATTGCTG TGATCGTCTT TTTCTTGATT
    GGATTTATGA TTGGCTACTT GGGCTATTGT AAAGGGGTAG
    AACCAAAAAC TGAGTGTGAG AGACTGGCAG GAACCGAGTC
    TCCAGTGAGG GAGGAGCCAG GAGAGGACTT CCCTGCAGCA
    CGTCGCTTAT ATTGGGATGA CCTGAAGAGA AAGTTGTCGG
    AGAAACTGGA CAGCACAGAC TTCACCGGCA CCATCAAGCT
    GCTGAATGAA AATTCATATG TCCCTCGTGA GGCTGGATCT
    CAAAAAGATG AAAATCTTGC GTTGTATGTT GAAAATCAAT
    TTCGTGAATT TAAACTCAGC AAAGTCTGGC GTGATCAACA
    TTTTGTTAAG ATTCAGGTCA AAGACAGCGC TCAAAACTCG
    GTGATCATAG TTGATAAGAA CGGTAGACTT GTTTACCTGG
    TGGAGAATCC TGGGGGTTAT GTGGCGTATA GTAAGGCTGC
    AACAGTTACT GGTAAACTGG TCCATGCTAA TTTTGGTACT
    AAAAAAGATT TTGAGGATTT ATACACTCCT GTGAATGGAT
    CTATAGTGAT TGTCAGAGCA GGGAAAATCA CCTTTGCAGA
    AAAGGTTGCA AATGCTGAAA GCTTAAATGC AATTGGTGTG
    TTGATATACA TGGACCAGAC TAAATTTCCC ATTGTTAACG
    CAGAACTTTC ATTCTTTGGA CATGCTCATC TGGGGACAGG
    TGACCCTTAC ACACCTGGAT TCCCTTCCTT CAATCACACT
    CAGTTTCCAC CATCTCGGTC ATCAGGATTG CCTAATATAC
    CTGTCCAGAC AATCTCCAGA GCTGCTGCAG AAAAGCTGTT
    TGGGAATATG GAAGGAGACT GTCCCTCTGA CTGGAAAACA
    GACTCTACAT GTAGGATGGT AACCTCAGAA AGCAAGAATG
    TGAAGCTCAC TGTGAGCAAT GTGCTGAAAG AGATAAAAAT
    TCTTAACATC TTTGGAGTTA TTAAAGGCTT TGTAGAACCA
    GATCACTATG TTGTAGTTGG GGCCCAGAGA GATGCATGGG
    GCCCTGGAGC TGCAAAATCC GGTGTAGGCA CAGCTCTCCT
    ATTGAAACTT GCCCAGATGT TCTCAGATAT GGTCTTAAAA
    GATGGGTTTC AGCCCAGCAG AAGCATTATC TTTGCCAGTT
    GGAGTGCTGG AGACTTTGGA TCGGTTGGTG CCACTGAATG
    GCTAGAGGGA TACCTTTCGT CCCTGCATTT AAAGGCTTTC
    ACTTATATTA ATCTGGATAA AGCGGTTCTT GGTACCAGCA
    ACTTCAAGGT TTCTGCCAGC CCACTGTTGT ATACGCTTAT
    TGAGAAAACA ATGCAAAATG TGAAGCATCC GGTTACTGGG
    CAATTTCTAT ATCAGGACAG CAACTGGGCC AGCAAAGTTG
    AGAAACTCAC TTTAGACAAT GCTGCTTTCC CTTTCCTTGC
    ATATTCTGGA ATCCCAGCAG TTTCTTTCTG TTTTTGCGAG
    GACACAGATT ATCCTTATTT GGGTACCACC ATGGACACCT
    ATAAGGAACT GATTGAGAGG ATTCCTGAGT TGAACAAAGT
    GGCACGAGCA GCTGCAGAGG TCGCTGGTCA GTTCGTGATT
    AAACTAACCC ATGATGTTGA ATTGAACCTG GACTATGAGA
    GGTACAACAG CCAACTGCTT TCATTTGTGA GGGATCTGAA
    CCAATACAGA GCAGACATAA AGGAAATGGG CCTGAGTTTA
    CAGTGGCTGT ATTCTGCTCG TGGAGACTTC TTCCGTGCTA
    CTTCCAGACT AACAACAGAT TTCGGGAATG CTGAGAAAAC
    AGACAGATTT GTCATGAAGA AACTCAATGA TCGTGTCATG
    AGAGTGGAGT ATCACTTCCT CTCTCCCTAC GTATCTCCAA
    AAGAGTCTCC TTTCCGACAT GTCTTCTGGG GCTCCGGCTC
    TCACACGCTG CCAGCTTTAC TGGAGAACTT GAAACTGCGT
    AAACAAAATA ACGGTGCTTT TAATGAAACG CTGTTCAGAA
    ACCAGTTGGC TCTAGCTACT TGGACTATTC AGGGAGCTGC
    AAATGCCCTC TCTGGTGACG TTTGGGACAT TGACAATGAG
    TTTTAAATGT GATACCCATA GCTTCCATGA GAACAGCAGG
    GTAGTCTGGT TTCTAGACTT GTGCTGATCG TGCTAAATTT
    TCAGTAGGGC TACAAAACCT GATGTTAAAA TTCCATCCCA
    TCATCTTGGT ACTACTAGAT GTCTTTAGGC AGCAGCTTTT
    AATACAGGGT AGATAACCTG TACTTCAAGT TAAAGTGAAT
    AACCACTTAA AAAATGTCCA TGATGGAATA TTCCCCTATC
    TCTAGAATTT TAAGTGCTTT GTAATGGGAA CTGCCTCTTT
    CCTGTTGTTG TTAATGAAAA TGTCAGAAAC CAGTTATGTG
    AATGATCTCT CTGAATCCTA AGGGCTGGTC TCTGCTGAAG
    GTTGTAAGTG GTCGCTTACT TTGAGTGATC CTCCAACTTC
    ATTTGATGCT AAATAGGAGA TACCAGGTTG AAAGACCTTC
    TCCAAATGAG ATCTAAGCCT TTCCATAAGG AATGTAGCTG
    GTTTCCTCAT TCCTGAAAGA AACAGTTAAC TTTCAGAAGA
    GATGGGCTTG TTTTCTTGCC AATGAGGTCT GAAATGGAGG
    TCCTTCTGCT GGATAAAATG AGGTTCAACT GTTGATTGCA
    GGAATAAGGC CTTAATATGT TAACCTCAGT GTCATTTATG
    AAAAGAGGGG ACCAGAAGCC AAAGACTTAG TATATTTTCT
    TTTCCTCTGT CCCTTCCCCC ATAAGCCTCC ATTTAGTTCT
    TTGTTATTTT TGTTTCTTCC AAAGCACATT GAAAGAGAAC
    CAGTTTCAGG TGTTTAGTTG CAGACTCAGT TTGTCAGACT
    TTAAAGAATA ATATGCTGCC AAATTTTGGC CAAAGTGTTA
    ATCTTAGGGG AGAGCTTTCT GTCCTTTTGG CACTGAGATA
    TTTATTGTTT ATTTATCAGT GACAGAGTTC ACTATAAATG
    GTGTTTTTTT AATAGAATAT AATTATCGGA AGCAGTGCCT
    TCCATAATTA TGACAGTTAT ACTGTCGGTT TTTTTTAAAT
    AAAAGCAGCA TCTGCTAATA AAACCCAACA GATACTGGAA
    GTTTTGCATT TATGGTCAAC ACTTAAGGGT TTTAGAAAAC
    AGCCGTCAGC CAAATGTAAT TGAATAAAGT TGAAGCTAAG
    ATTTAGAGAT GAATTAAATT TAATTAGGGG TTGCTAAGAA
    GCGAGCACTG ACCAGATAAG AATGCTGGTT TTCCTAAATG
    CAGTGAATTG TGACCAAGTT ATAAATCAAT GTCACTTAAA
    GGCTGTGGTA GTACTCCTGC AAAATTTTAT AGCTCAGTTT
    ATCCAAGGTG TAACTCTAAT TCCCATTTTG CAAAATTTCC
    AGTACCTTTG TCACAATCCT AACACATTAT CGGGAGCAGT
    GTCTTCCATA ATGTATAAAG AACAAGGTAG TTTTTACCTA
    CCACAGTGTC TGTATCGGAG ACAGTGATCT CCATATGTTA
    CACTAAGGGT GTAAGTAATT ATCGGGAACA GTGTTTCCCA
    TAATTTTCTT CATGCAATGA CATCTTCAAA GCTTGAAGAT
    CGTTAGTATC TAACATGTAT CCCAACTCCT ATAATTCCCT
    ATCTTTTAGT TTTAGTTGCA GAAACATTTT GTGGTCATTA
    AGCATTGGGT GGGTAAATTC AACCACTGTA AAATGAAATT
    ACTACAAAAT TTGAAATTTA GCTTGGGTTT TTGTTACCTT
    TATGGTTTCT CCAGGTCCTC TACTTAATGA GATAGTAGCA
    TACATTTATA ATGTTTGCTA TTGACAAGTC ATTTTAACTT
    TATCACATTA TTTGCATGTT ACCTCCTATA AACTTAGTGC
    GGACAAGTTT TAATCCAGAA TTGACCTTTT GACTTAAAGC
    AGAGGGACTT TGTATAGAAG GTTTGGGGGC TGTGGGGAAG
    GAGAGTCCCC TGAAGGTCTG ACACGTCTGC CTACCCATTC
    GTGGTGATCA ATTAAATGTA GGTATGAATA AGTTCGAAGC
    TCCGTGAGTG AACCATCATT ATAAACGTGA TGATCAGCTG
    TTTGTCATAG GGCAGTTGGA AACGGCCTCC TAGGGAAAAG
    TTCATAGGGT CTCTTCAGGT TCTTAGTGTC ACTTACCTAG
    ATTTACAGCC TCACTTGAAT GTGTCACTAC TCACAGTCTC
    TTTAATCTTC AGTTTTATCT TTAATCTCCT CTTTTATCTT
    GGACTGACAT TTAGCGTAGC TAAGTGAAAA GGTCATAGCT
    GAGATTCCTG GTTCGGGTGT TACGCACACG TACTTAAATG
    AAAGCATGTG GCATGTTCAT CGTATAACAC AATATGAATA
    CAGGGCATGC ATTTTGCAGC AGTGAGTCTC TTCAGAAAAC
    CCTTTTCTAC AGTTAGGGTT GAGTTACTTC CTATCAAGCC
    AGTACGTGCT AACAGGCTCA ATATTCCTGA ATGAAATATC
    AGACTAGTGA CAAGCTCCTG GTCTTGAGAT GTCTTCTCGT
    TAAGGAGATG GGCCTTTTGG AGGTAAAGGA TAAAATGAAT
    GAGTTCTGTC ATGATTCACT ATTCTAGAAC TTGCATGACC
    TTTACTGTGT TAGCTCTTTG AATGTTCTTG AAATTTTAGA
    CTTTCTTTGT AAACAAATGA TATGTCCTTA TCATTGTATA
    AAAGCTGTTA TGTGCAACAG TGTGGAGATT CCTTGTCTGA
    TTTAATAAAA TACTTAAACA CTGAAAAAAA AAAA
    18S X03205.1 TACCTGGTTG ATCCTGCCAG TAGCATATGC TTGTCTCAAA 49
    GATTAAGCCA TGCATGTCTA AGTACGCACG GCCGGTACAG
    TGAAACTGCG AATGGCTCAT TAAATCAGTT ATGGTTCCTT
    TGGTCGCTCG CTCCTCTCCC ACTTGGATAA CTGTGGTAAT
    TCTAGAGCTA ATACATGCCG ACGGGCGCTG ACCCCCTTCG
    CGGGGGGGAT GCGTGCATTT ATCAGATCAA AACCAACCCG
    GTCAGCCCCT CTCCGGCCCC GGCCGGGGGG CGGGCGCCGG
    CGGCTTTGGT GACTCTAGAT AACCTCGGGC CGATCGCACG
    CCCCCCGTGG CGGCGACGAC CCATTCGAAC GTCTGCCCTA
    TCAACTTTCG ATGGTAGTCG CCGTGCCTAC CATGGTGACC
    ACGGGTGACG GGGAATCAGG GTTCGATTCC GGAGAGGGAG
    CCTGAGAAAC GGCTACCACA TCCAAGGAAG GCAGCAGGCG
    CGCAAATTAC CCACTCCCGA CCCGGGGAGG TAGTGACGAA
    AAATAACAAT ACAGGACTCT TTCGAGGCCC TGTAATTGGA
    ATGAGTCCAC TTTAAATCCT TTAACGAGGA TCCATTGGAG
    GGCAAGTCTG GTGCCAGCAG CCGCGGTAAT TCCAGCTCCA
    ATAGCGTATA TTAAAGTTGC TGCAGTTAAA AAGCTCGTAG
    TTGGATCTTG GGAGCGGGCG GGCGGTCCGC CGCGAGGCGA
    GCCACCGCCC GTCCCCGCCC CTTGCCTCTC GGCGCCCCCT
    CGATGCTCTT AGCTGAGTGT CCCGCGGGGC CCGAAGCGTT
    TACTTTGAAA AAATTAGAGT GTTCAAAGCA GGCCCGAGCC
    GCCTGGATAC CGCAGCTAGG AATAATGGAA TAGGACCGCG
    GTTCTATTTT GTTGGTTTTC GGAACTGAGG CCATGATTAA
    GAGGGACGGC CGGGGGCATT CGTATTGCGC CGCTAGAGGT
    GAAATTCTTG GACCGGCGCA AGACGGACCA GAGCGAAAGC
    ATTTGCCAAG AATGTTTTCA TTAATCAAGA ACGAAAGTCG
    GAGGTTCGAA GACGATCAGA TACCGTCGTA GTTCCGACCA
    TAAACGATGC CGACCGGCGA TGCGGCGGCG TTATTCCCAT
    GACCCGCCGG GCAGCTTCCG GGAAACCAAA GTCTTTGGGT
    TCCGGGGGGA GTATGGTTGC AAAGCTGAAA CTTAAAGGAA
    TTGACGGAAG GGCACCACCA GGAGTGGAGC CTGCGGCTTA
    ATTTGACTCA ACACGGGAAA CCTCACCCGG CCCGGACACG
    GACAGGATTG ACAGATTGAT AGCTCTTTCT CGATTCCGTG
    GGTGGTGGTG CATGGCCGTT CTTAGTTGGT GGAGCGATTT
    GTCTGGTTAA TTCCGATAAC GAACGAGACT CTGGCATGCT
    AACTAGTTAC GCGACCCCCG AGCGGTCGGC GTCCCCCAAC
    TTCTTAGAGG GACAAGTGGC GTTCAGCCAC CCGAGATTGA
    GCAATAACAG GTCTGTGATG CCCTTAGATG TCCGGGGCTG
    CACGCGCGCT ACACTGACTG GCTCAGCGTG TGCCTACCCT
    ACGCCGGCAG GCGCGGGTAA CCCGTTGAAC CCCATTCGTG
    ATGGGGATCG GGGATTGCAA TTATTCCCCA TGAACGAGGA
    ATTCCCAGTA AGTGCGGGTC ATAAGCTTGC GTTGATTAAG
    TCCCTGCCCT TTGTACACAC CGCCCGTCGC TACTACCGAT
    TGGATGGTTT AGTGAGGCCC TCGGATCGGC CCCGCCGGGG
    TCGGCCCACG GCCCTGGCGG AGCGCTGAGA AGACGGTCGA
    ACTTGACTAT CTAGAGGAAG TAAAAGTCGT AACAAGGTTT
    CCGTAGGTGA ACCTGCGGAA GGATCATTA
    PPIA NM_021130.4 GGGGCCGAAC GTGGTATAAA AGGGGCGGGA GGCCAGGCTC 50
    GTGCCGTTTT GCAGACGCCA CCGCCGAGGA AAACCGTGTA
    CTATTAGCCA TGGTCAACCC CACCGTGTTC TTCGACATTG
    CCGTCGACGG CGAGCCCTTG GGCCGCGTCT CCTTTGAGCT
    GTTTGCAGAC AAGGTCCCAA AGACAGCAGA AAATTTTCGT
    GCTCTGAGCA CTGGAGAGAA AGGATTTGGT TATAAGGGTT
    CCTGCTTTCA CAGAATTATT CCAGGGTTTA TGTGTCAGGG
    TGGTGACTTC ACACGCCATA ATGGCACTGG TGGCAAGTCC
    ATCTATGGGG AGAAATTTGA AGATGAGAAC TTCATCCTAA
    AGCATACGGG TCCTGGCATC TTGTCCATGG CAAATGCTGG
    ACCCAACACA AATGGTTCCC AGTTTTTCAT CTGCACTGCC
    AAGACTGAGT GGTTGGATGG CAAGCATGTG GTGTTTGGCA
    AAGTGAAAGA AGGCATGAAT ATTGTGGAGG CCATGGAGCG
    CTTTGGGTCC AGGAATGGCA AGACCAGCAA GAAGATCACC
    ATTGCTGACT GTGGACAACT CGAATAAGTT TGACTTGTGT
    TTTATCTTAA CCACCAGATC ATTCCTTCTG TAGCTCAGGA
    GAGCACCCCT CCACCCCATT TGCTCGCAGT ATCCTAGAAT
    CTTTGTGCTC TCGCTGCAGT TCCCTTTGGG TTCCATGTTT
    TCCTTGTTCC CTCCCATGCC TAGCTGGATT GCAGAGTTAA
    GTTTATGATT ATGAAATAAA AACTAAATAA CAATTGTCCT
    CGTTTGAGTT AAGAGTGTTG ATGTAGGCTT TATTTTAAGC
    AGTAATGGGT TACTTCTGAA ACATCACTTG TTTGCTTAAT
    TCTACACAGT ACTTAGATTT TTTTTACTTT CCAGTCCCAG
    GAAGTGTCAA TGTTTGTTGA GTGGAATATT GAAAATGTAG
    GCAGCAACTG GGCATGGTGG CTCACTGTCT GTAATGTATT
    ACCTGAGGCA GAAGACCACC TGAGGGTAGG AGTCAAGATC
    AGCCTGGGCA ACATAGTGAG ACGCTGTCTC TACAAAAAAT
    AATTAGCCTG GCCTGGTGGT GCATGCCTAG TCCTAGCTGA
    TCTGGAGGCT GACGTGGGAG GATTGCTTGA GCCTAGAGTG
    AGCTATTATC ATGCCACTGT ACAGCCTGGG TGTTCACAGA
    TCTTGTGTCT CAAAGGTAGG CAGAGGCAGG AAAAGCAAGG
    AGCCAGAATT AAGAGGTTGG GTCAGTCTGC AGTGAGTTCA
    TGCATTTAGA GGTGTTCTTC AAGATGACTA ATGTCAAAAA
    TTGAGACATC TGTTGCGGTT TTTTTTTTTT TTTTTTCCCC
    TGGAATGCAG TGGCGTGATC TCAGCTCACT GCAGCCTCCG
    CCTCCTGGGT TCAAGTGATT CTAGTGCCTC AGCCTCCTGA
    GTAGCTGGGA TAATGGGCGT GTGCCACCAT GCCCAGCTAA
    TTTTTGTATT TTTAGTATAG ATGGGGTTTC ATCATTTTGA
    CCAGGCTGGT CTCAAACTCT TGACCTCAGC TGATGCGCCT
    GCCTTGGCCT CCCAAACTGC TGAGATTACA GATGTGAGCC
    ACCGCACCCT ACCTCATTTT CTGTAACAAA GCTAAGCTTG
    AACACTGTTG ATGTTCTTGA GGGAAGCATA TTGGGCTTTA
    GGCTGTAGGT CAAGTTTATA CATCTTAATT ATGGTGGAAT
    TCCTATGTAG AGTCTAAAAA GCCAGGTACT TGGTGCTACA
    GTCAGTCTCC CTGCAGAGGG TTAAGGCGCA GACTACCTGC
    AGTGAGGAGG TACTGCTTGT AGCATATAGA GCCTCTCCCT
    AGCTTTGGTT ATGGAGGCTT TGAGGTTTTG CAAACCTGAC
    CAATTTAAGC CATAAGATCT GGTCAAAGGG ATACCCTTCC
    CACTAAGGAC TTGGTTTCTC AGGAAATTAT ATGTACAGTG
    CTTGCTGGCA GTTAGATGTC AGGACAATCT AAGCTGAGAA
    AACCCCTTCT CTGCCCACCT TAACAGACCT CTAGGGTTCT
    TAACCCAGCA ATCAAGTTTG CCTATCCTAG AGGTGGCGGA
    TTTGATCATT TGGTGTGTTG GGCAATTTTT GTTTTACTGT
    CTGGTTCCTT CTGCGTGAAT TACCACCACC ACCACTTGTG
    CATCTCAGTC TTGTGTGTTG TCTGGTTACG TATTCCCTGG
    GTGATACCAT TCAATGTCTT AATGTACTTG TGGCTCAGAC
    CTGAGTGCAA GGTGGAAATA AACATCAAAC ATCTTTTCAT
    TATCCCTA
    PGK1 NM_000291.3 GAGAGCAGCG GCCGGGAAGG GGCGGTGCGG GAGGCGGGGT 51
    GTGGGGCGGT AGTGTGGGCC CTGTTCCTGC CCGCGCGGTG
    TTCCGCATTC TGCAAGCCTC CGGAGCGCAC GTCGGCAGTC
    GGCTCCCTCG TTGACCGAAT CACCGACCTC TCTCCCCAGC
    TGTATTTCCA AAATGTCGCT TTCTAACAAG CTGACGCTGG
    ACAAGCTGGA CGTTAAAGGG AAGCGGGTCG TTATGAGAGT
    CGACTTCAAT GTTCCTATGA AGAACAACCA GATAACAAAC
    AACCAGAGGA TTAAGGCTGC TGTCCCAAGC ATCAAATTCT
    GCTTGGACAA TGGAGCCAAG TCGGTAGTCC TTATGAGCCA
    CCTAGGCCGG CCTGATGGTG TGCCCATGCC TGACAAGTAC
    TCCTTAGAGC CAGTTGCTGT AGAACTCAAA TCTCTGCTGG
    GCAAGGATGT TCTGTTCTTG AAGGACTGTG TAGGCCCAGA
    AGTGGAGAAA GCCTGTGCCA ACCCAGCTGC TGGGTCTGTC
    ATCCTGCTGG AGAACCTCCG CTTTCATGTG GAGGAAGAAG
    GGAAGGGAAA AGATGCTTCT GGGAACAAGG TTAAAGCCGA
    GCCAGCCAAA ATAGAAGCTT TCCGAGCTTC ACTTTCCAAG
    CTAGGGGATG TCTATGTCAA TGATGCTTTT GGCACTGCTC
    ACAGAGCCCA CAGCTCCATG GTAGGAGTCA ATCTGCCACA
    GAAGGCTGGT GGGTTTTTGA TGAAGAAGGA GCTGAACTAC
    TTTGCAAAGG CCTTGGAGAG CCCAGAGCGA CCCTTCCTGG
    CCATCCTGGG CGGAGCTAAA GTTGCAGACA AGATCCAGCT
    CATCAATAAT ATGCTGGACA AAGTCAATGA GATGATTATT
    GGTGGTGGAA TGGCTTTTAC CTTCCTTAAG GTGCTCAACA
    ACATGGAGAT TGGCACTTCT CTGTTTGATG AAGAGGGAGC
    CAAGATTGTC AAAGACCTAA TGTCCAAAGC TGAGAAGAAT
    GGTGTGAAGA TTACCTTGCC TGTTGACTTT GTCACTGCTG
    ACAAGTTTGA TGAGAATGCC AAGACTGGCC AAGCCACTGT
    GGCTTCTGGC ATACCTGCTG GCTGGATGGG CTTGGACTGT
    GGTCCTGAAA GCAGCAAGAA GTATGCTGAG GCTGTCACTC
    GGGCTAAGCA GATTGTGTGG AATGGTCCTG TGGGGGTATT
    TGAATGGGAA GCTTTTGCCC GGGGAACCAA AGCTCTCATG
    GATGAGGTGG TGAAAGCCAC TTCTAGGGGC TGCATCACCA
    TCATAGGTGG TGGAGACACT GCCACTTGCT GTGCCAAATG
    GAACACGGAG GATAAAGTCA GCCATGTGAG CACTGGGGGT
    GGTGCCAGTT TGGAGCTCCT GGAAGGTAAA GTCCTTCCTG
    GGGTGGATGC TCTCAGCAAT ATTTAGTACT TTCCTGCCTT
    TTAGTTCCTG TGCACAGCCC CTAAGTCAAC TTAGCATTTT
    CTGCATCTCC ACTTGGCATT AGCTAAAACC TTCCATGTCA
    AGATTCAGCT AGTGGCCAAG AGATGCAGTG CCAGGAACCC
    TTAAACAGTT GCACAGCATC TCAGCTCATC TTCACTGCAC
    CCTGGATTTG CATACATTCT TCAAGATCCC ATTTGAATTT
    TTTAGTGACT AAACCATTGT GCATTCTAGA GTGCATATAT
    TTATATTTTG CCTGTTAAAA AGAAAGTGAG CAGTGTTAGC
    TTAGTTCTCT TTTGATGTAG GTTATTATGA TTAGCTTTGT
    CACTGTTTCA CTACTCAGCA TGGAAACAAG ATGAAATTCC
    ATTTGTAGGT AGTGAGACAA AATTGATGAT CCATTAAGTA
    AACAATAAAA GTGTCCATTG AAACCGTGAT TTTTTTTTTT
    TTCCTGTCAT ACTTTGTTAG GAAGGGTGAG AATAGAATCT
    TGAGGAACGG ATCAGATGTC TATATTGCTG AATGCAAGAA
    GTGGGGCAGC AGCAGTGGAG AGATGGGACA ATTAGATAAA
    TGTCCATTCT TTATCAAGGG CCTACTTTAT GGCAGACATT
    GTGCTAGTGC TTTTATTCTA ACTTTTATTT TTATCAGTTA
    CACATGATCA TAATTTAAAA AGTCAAGGCT TATAACAAAA
    AAGCCCCAGC CCATTCCTCC CATTCAAGAT TCCCACTCCC
    CAGAGGTGAC CACTTTCAAC TCTTGAGTTT TTCAGGTATA
    TACCTCCATG TTTCTAAGTA ATATGCTTAT ATTGTTCACT
    TCTTTTTTTT TTATTTTTTA AAGAAATCTA TTTCATACCA
    TGGAGGAAGG CTCTGTTCCA CATATATTTC CACTTCTTCA
    TTCTCTCGGT ATAGTTTTGT CACAATTATA GATTAGATCA
    AAAGTCTACA TAACTAATAC AGCTGAGCTA TGTAGTATGC
    TATGATTAAA TTTACTTATG TAAAAAAAAA AAAAAAAAA
    RPL13A NM_012423.3 CACTTCTGCC GCCCCTGTTT CAAGGGATAA GAAACCCTGC 52
    GACAAAACCT CCTCCTTTTC CAAGCGGCTG CCGAAGATGG
    CGGAGGTGCA GGTCCTGGTG CTTGATGGTC GAGGCCATCT
    CCTGGGCCGC CTGGCGGCCA TCGTGGCTAA ACAGGTACTG
    CTGGGCCGGA AGGTGGTGGT CGTACGCTGT GAAGGCATCA
    ACATTTCTGG CAATTTCTAC AGAAACAAGT TGAAGTACCT
    GGCTTTCCTC CGCAAGCGGA TGAACACCAA CCCTTCCCGA
    GGCCCCTACC ACTTCCGGGC CCCCAGCCGC ATCTTCTGGC
    GGACCGTGCG AGGTATGCTG CCCCACAAAA CCAAGCGAGG
    CCAGGCCGCT CTGGACCGTC TCAAGGTGTT TGACGGCATC
    CCACCGCCCT ACGACAAGAA AAAGCGGATG GTGGTTCCTG
    CTGCCCTCAA GGTCGTGCGT CTGAAGCCTA CAAGAAAGTT
    TGCCTATCTG GGGCGCCTGG CTCACGAGGT TGGCTGGAAG
    TACCAGGCAG TGACAGCCAC CCTGGAGGAG AAGAGGAAAG
    AGAAAGCCAA GATCCACTAC CGGAAGAAGA AACAGCTCAT
    GAGGCTACGG AAACAGGCCG AGAAGAACGT GGAGAAGAAA
    ATTGACAAAT ACACAGAGGT CCTCAAGACC CACGGACTCC
    TGGTCTGAGC CCAATAAAGA CTGTTAATTC CTCATGCGTT
    GCCTGCCCTT CCTCCATTGT TGCCCTGGAA TGTACGGGAC
    CCAGGGGCAG CAGCAGTCCA GGTGCCACAG GCAGCCCTGG
    GACATAGGAA GCTGGGAGCA AGGAAAGGGT CTTAGTCACT
    GCCTCCCGAA GTTGCTTGAA AGCACTCGGA GAATTGTGCA
    GGTGTCATTT ATCTATGACC AATAGGAAGA GCAACCAGTT
    ACTATGAGTG AAAGGGAGCC AGAAGACTGA TTGGAGGGCC
    CTATCTTGTG AGTGGGGCAT CTGTTGGACT TTCCACCTGG
    TCATATACTC TGCAGCTGTT AGAATGTGCA AGCACTTGGG
    GACAGCATGA GCTTGCTGTT GTACACAGGG TATTTCTAGA
    AGCAGAAATA GACTGGGAAG ATGCACAACC AAGGGGTTAC
    AGGCATCGCC CATGCTCCTC ACCTGTATTT TGTAATCAGA
    AATAAATTGC TTTTAAAGAA AAAAAAAAAA AAAAAA
    B2M NM_004048.2 AATATAAGTG GAGGCGTCGC GCTGGCGGGC ATTCCTGAAG 53
    CTGACAGCAT TCGGGCCGAG ATGTCTCGCT CCGTGGCCTT
    AGCTGTGCTC GCGCTACTCT CTCTTTCTGG CCTGGAGGCT
    ATCCAGCGTA CTCCAAAGAT TCAGGTTTAC TCACGTCATC
    CAGCAGAGAA TGGAAAGTCA AATTTCCTGA ATTGCTATGT
    GTCTGGGTTT CATCCATCCG ACATTGAAGT TGACTTACTG
    AAGAATGGAG AGAGAATTGA AAAAGTGGAG CATTCAGACT
    TGTCTTTCAG CAAGGACTGG TCTTTCTATC TCTTGTACTA
    CACTGAATTC ACCCCCACTG AAAAAGATGA GTATGCCTGC
    CGTGTGAACC ATGTGACTTT GTCACAGCCC AAGATAGTTA
    AGTGGGATCG AGACATGTAA GCAGCATCAT GGAGGTTTGA
    AGATGCCGCA TTTGGATTGG ATGAATTCCA AATTCTGCTT
    GCTTGCTTTT TAATATTGAT ATGCTTATAC ACTTACACTT
    TATGCACAAA ATGTAGGGTT ATAATAATGT TAACATGGAC
    ATGATCTTCT TTATAATTCT ACTTTGAGTG CTGTCTCCAT
    GTTTGATGTA TCTGAGCAGG TTGCTCCACA GGTAGCTCTA
    GGAGGGCTGG CAACTTAGAG GTGGGGAGCA GAGAATTCTC
    TTATCCAACA TCAACATCTT GGTCAGATTT GAACTCTTCA
    ATCTCTTGCA CTCAAAGCTT GTTAAGATAG TTAAGCGTGC
    ATAAGTTAAC TTCCAATTTA CATACTCTGC TTAGAATTTG
    GGGGAAAATT TAGAAATATA ATTGACAGGA TTATTGGAAA
    TTTGTTATAA TGAATGAAAC ATTTTGTCAT ATAAGATTCA
    TATTTACTTC TTATACATTT GATAAAGTAA GGCATGGTTG
    TGGTTAATCT GGTTTATTTT TGTTCCACAA GTTAAATAAA
    TCATAAAACT TGATGTGTTA TCTCTTA
    YWHAZ NM_003406.3 CTTTCTCCTT CCCCTTCTTC CGGGCTCCCG TCCCGGCTCA 54
    TCACCCGGCC TGTGGCCCAC TCCCACCGCC AGCTGGAACC
    CTGGGGACTA CGACGTCCCT CAAACCTTGC TTCTAGGAGA
    TAAAAAGAAC ATCCAGTCAT GGATAAAAAT GAGCTGGTTC
    AGAAGGCCAA ACTGGCCGAG CAGGCTGAGC GATATGATGA
    CATGGCAGCC TGCATGAAGT CTGTAACTGA GCAAGGAGCT
    GAATTATCCA ATGAGGAGAG GAATCTTCTC TCAGTTGCTT
    ATAAAAATGT TGTAGGAGCC CGTAGGTCAT CTTGGAGGGT
    CGTCTCAAGT ATTGAACAAA AGACGGAAGG TGCTGAGAAA
    AAACAGCAGA TGGCTCGAGA ATACAGAGAG AAAATTGAGA
    CGGAGCTAAG AGATATCTGC AATGATGTAC TGTCTCTTTT
    GGAAAAGTTC TTGATCCCCA ATGCTTCACA AGCAGAGAGC
    AAAGTCTTCT ATTTGAAAAT GAAAGGAGAT TACTACCGTT
    ACTTGGCTGA GGTTGCCGCT GGTGATGACA AGAAAGGGAT
    TGTCGATCAG TCACAACAAG CATACCAAGA AGCTTTTGAA
    ATCAGCAAAA AGGAAATGCA ACCAACACAT CCTATCAGAC
    TGGGTCTGGC CCTTAACTTC TCTGTGTTCT ATTATGAGAT
    TCTGAACTCC CCAGAGAAAG CCTGCTCTCT TGCAAAGACA
    GCTTTTGATG AAGCCATTGC TGAACTTGAT ACATTAAGTG
    AAGAGTCATA CAAAGACAGC ACGCTAATAA TGCAATTACT
    GAGAGACAAC TTGACATTGT GGACATCGGA TACCCAAGGA
    GACGAAGCTG AAGCAGGAGA AGGAGGGGAA AATTAACCGG
    CCTTCCAACT TTTGTCTGCC TCATTCTAAA ATTTACACAG
    TAGACCATTT GTCATCCATG CTGTCCCACA AATAGTTTTT
    TGTTTACGAT TTATGACAGG TTTATGTTAC TTCTATTTGA
    ATTTCTATAT TTCCCATGTG GTTTTTATGT TTAATATTAG
    GGGAGTAGAG CCAGTTAACA TTTAGGGAGT TATCTGTTTT
    CATCTTGAGG TGGCCAATAT GGGGATGTGG AATTTTTATA
    CAAGTTATAA GTGTTTGGCA TAGTACTTTT GGTACATTGT
    GGCTTCAAAA GGGCCAGTGT AAAACTGCTT CCATGTCTAA
    GCAAAGAAAA CTGCCTACAT ACTGGTTTGT CCTGGCGGGG
    AATAAAAGGG ATCATTGGTT CCAGTCACAG GTGTAGTAAT
    TGTGGGTACT TTAAGGTTTG GAGCACTTAC AAGGCTGTGG
    TAGAATCATA CCCCATGGAT ACCACATATT AAACCATGTA
    TATCTGTGGA ATACTCAATG TGTACACCTT TGACTACAGC
    TGCAGAAGTG TTCCTTTAGA CAAAGTTGTG ACCCATTTTA
    CTCTGGATAA GGGCAGAAAC GGTTCACATT CCATTATTTG
    TAAAGTTACC TGCTGTTAGC TTTCATTATT TTTGCTACAC
    TCATTTTATT TGTATTTAAA TGTTTTAGGC AACCTAAGAA
    CAAATGTAAA AGTAAAGATG CAGGAAAAAT GAATTGCTTG
    GTATTCATTA CTTCATGTAT ATCAAGCACA GCAGTAAAAC
    AAAAACCCAT GTATTTAACT TTTTTTTAGG ATTTTTGCTT
    TTGTGATTTT TTTTTTTTTG ATACTTGCCT AACATGCATG
    TGCTGTAAAA ATAGTTAACA GGGAAATAAC TTGAGATGAT
    GGCTAGCTTT GTTTAATGTC TTATGAAATT TTCATGAACA
    ATCCAAGCAT AATTGTTAAG AACACGTGTA TTAAATTCAT
    GTAAGTGGAA TAAAAGTTTT ATGAATGGAC TTTTCAACTA
    CTTTCTCTAC AGCTTTTCAT GTAAATTAGT CTTGGTTCTG
    AAACTTCTCT AAAGGAAATT GTACATTTTT TGAAATTTAT
    TCCTTATTCC CTCTTGGCAG CTAATGGGCT CTTACCAAGT
    TTAAACACAA AATTTATCAT AACAAAAATA CTACTAATAT
    AACTACTGTT TCCATGTCCC ATGATCCCCT CTCTTCCTCC
    CCACCCTGAA AAAAATGAGT TCCTATTTTT TCTGGGAGAG
    GGGGGGATTG ATTAGAAAAA AATGTAGTGT GTTCCATTTA
    AAATTTTGGC ATATGGCATT TTCTAACTTA GGAAGCCACA
    ATGTTCTTGG CCCATCATGA CATTGGGTAG CATTAACTGT
    AAGTTTTGTG CTTCCAAATC ACTTTTTGGT TTTTAAGAAT
    TTCTTGATAC TCTTATAGCC TGCCTTCAAT TTTGATCCTT
    TATTCTTTCT ATTTGTCAGG TGCACAAGAT TACCTTCCTG
    TTTTAGCCTT CTGTCTTGTC ACCAACCATT CTTACTTGGT
    GGCCATGTAC TTGGAAAAAG GCCGCATGAT CTTTCTGGCT
    CCACTCAGTG TCTAAGGCAC CCTGCTTCCT TTGCTTGCAT
    CCCACAGACT ATTTCCCTCA TCCTATTTAC TGCAGCAAAT
    CTCTCCTTAG TTGATGAGAC TGTGTTTATC TCCCTTTAAA
    ACCCTACCTA TCCTGAATGG TCTGTCATTG TCTGCCTTTA
    AAATCCTTCC TCTTTCTTCC TCCTCTATTC TCTAAATAAT
    GATGGGGCTA AGTTATACCC AAAGCTCACT TTACAAAATA
    TTTCCTCAGT ACTTTGCAGA AAACACCAAA CAAAAATGCC
    ATTTTAAAAA AGGTGTATTT TTTCTTTTAG AATGTAAGCT
    CCTCAAGAGC AGGGACAATG TTTTCTGTAT GTTCTATTGT
    GCCTAGTACA CTGTAAATGC TCAATAAATA TTGATGATGG
    GAGGCAGTGA GTCTTGATGA TAAGGGTGAG AAACTGAAAT
    CCCAAACACT GTTTTGTTGC TTGTTTTATT ATGACCTCAG
    ATTAAATTGG GAAATATTGG CCCTTTTGAA TAATTGTCCC
    AAATATTACA TTCAAATAAA AGTGCAATGG AGAAAAAAAA
    AAA
    SDHA NM_004168.3 ACTGCAGCCC CGCTCGACTC CGGCGTGGTG CGCAGGCGCG 55
    GTATCCCCCC TCCCCCGCCA GCTCGACCCC GGTGTGGTGC
    GCAGGCGCAG TCTGCGCAGG GACTGGCGGG ACTGCGCGGC
    GGCAACAGCA GACATGTCGG GGGTCCGGGG CCTGTCGCGG
    CTGCTGAGCG CTCGGCGCCT GGCGCTGGCC AAGGCGTGGC
    CAACAGTGTT GCAAACAGGA ACCCGAGGTT TTCACTTCAC
    TGTTGATGGG AACAAGAGGG CATCTGCTAA AGTTTCAGAT
    TCCATTTCTG CTCAGTATCC AGTAGTGGAT CATGAATTTG
    ATGCAGTGGT GGTAGGCGCT GGAGGGGCAG GCTTGCGAGC
    TGCATTTGGC CTTTCTGAGG CAGGGTTTAA TACAGCATGT
    GTTACCAAGC TGTTTCCTAC CAGGTCACAC ACTGTTGCAG
    CACAGGGAGG AATCAATGCT GCTCTGGGGA ACATGGAGGA
    GGACAACTGG AGGTGGCATT TCTACGACAC CGTGAAGGGC
    TCCGACTGGC TGGGGGACCA GGATGCCATC CACTACATGA
    CGGAGCAGGC CCCCGCCGCC GTGGTCGAGC TAGAAAATTA
    TGGCATGCCG TTTAGCAGAA CTGAAGATGG GAAGATTTAT
    CAGCGTGCAT TTGGTGGACA GAGCCTCAAG TTTGGAAAGG
    GCGGGCAGGC CCATCGGTGC TGCTGTGTGG CTGATCGGAC
    TGGCCACTCG CTATTGCACA CCTTATATGG AAGGTCTCTG
    CGATATGATA CCAGCTATTT TGTGGAGTAT TTTGCCTTGG
    ATCTCCTGAT GGAGAATGGG GAGTGCCGTG GTGTCATCGC
    ACTGTGCATA GAGGACGGGT CCATCCATCG CATAAGAGCA
    AAGAACACTG TTGTTGCCAC AGGAGGCTAC GGGCGCACCT
    ACTTCAGCTG CACGTCTGCC CACACCAGCA CTGGCGACGG
    CACGGCCATG ATCACCAGGG CAGGCCTTCC TTGCCAGGAC
    CTAGAGTTTG TTCAGTTCCA CCCTACAGGC ATATATGGTG
    CTGGTTGTCT CATTACGGAA GGATGTCGTG GAGAGGGAGG
    CATTCTCATT AACAGTCAAG GCGAAAGGTT TATGGAGCGA
    TACGCCCCTG TCGCGAAGGA CCTGGCGTCT AGAGATGTGG
    TGTCTCGGTC CATGACTCTG GAGATCCGAG AAGGAAGAGG
    CTGTGGCCCT GAGAAAGATC ACGTCTACCT GCAGCTGCAC
    CACCTACCTC CAGAGCAGCT GGCCACGCGC CTGCCTGGCA
    TTTCAGAGAC AGCCATGATC TTCGCTGGCG TGGACGTCAC
    GAAGGAGCCG ATCCCTGTCC TCCCCACCGT GCATTATAAC
    ATGGGCGGCA TTCCCACCAA CTACAAGGGG CAGGTCCTGA
    GGCACGTGAA TGGCCAGGAT CAGATTGTGC CCGGCCTGTA
    CGCCTGTGGG GAGGCCGCCT GTGCCTCGGT ACATGGTGCC
    AACCGCCTCG GGGCAAACTC GCTCTTGGAC CTGGTTGTCT
    TTGGTCGGGC ATGTGCCCTG AGCATCGAAG AGTCATGCAG
    GCCTGGAGAT AAAGTCCCTC CAATTAAACC AAACGCTGGG
    GAAGAATCTG TCATGAATCT TGACAAATTG AGATTTGCTG
    ATGGAAGCAT AAGAACATCG GAACTGCGAC TCAGCATGCA
    GAAGTCAATG CAAAATCATG CTGCCGTGTT CCGTGTGGGA
    AGCGTGTTGC AAGAAGGTTG TGGGAAAATC AGCAAGCTCT
    ATGGAGACCT AAAGCACCTG AAGACGTTCG ACCGGGGAAT
    GGTCTGGAAC ACGGACCTGG TGGAGACCCT GGAGCTGCAG
    AACCTGATGC TGTGTGCGCT GCAGACCATC TACGGAGCAG
    AGGCACGGAA GGAGTCACGG GGCGCGCATG CCAGGGAAGA
    CTACAAGGTG CGGATTGATG AGTACGATTA CTCCAAGCCC
    ATCCAGGGGC AACAGAAGAA GCCCTTTGAG GAGCACTGGA
    GGAAGCACAC CCTGTCCTAT GTGGACGTTG GCACTGGGAA
    GGTCACTCTG GAATATAGAC CCGTGATCGA CAAAACTTTG
    AACGAGGCTG ACTGTGCCAC CGTCCCGCCA GCCATTCGCT
    CCTACTGATG AGACAAGATG TGGTGATGAC AGAATCAGCT
    TTTGTAATTA TGTATAATAG CTCATGCATG TGTCCATGTC
    ATAACTGTCT TCATACGCTT CTGCACTCTG GGGAAGAAGG
    AGTACATTGA AGGGAGATTG GCACCTAGTG GCTGGGAGCT
    TGCCAGGAAC CCAGTGGCCA GGGAGCGTGG CACTTACCTT
    TGTCCCTTGC TTCATTCTTG TGAGATGATA AAACTGGGCA
    CAGCTCTTAA ATAAAATATA AATGAACAAA CTTTCTTTTA
    TTTCCAAATC CATTTGAAAT ATTTTACTGT TGTGACTTTA
    GTCATATTTG TTGACCTAAA AATCAAATGT AATCTTTGTA
    TTGTGTTACA TCAAAATCCA GATATTTTGT ATAGTTTCTT
    TTTTCTTTTT CTTTTCTTTT TTTTTTTTGA GACAGGATCG
    GTGCAGTAGT ACAATCACAG CTCACTGCAG CCTCAAACTC
    CTGGGCAGCT CAGGTGATCT TCCTGACTCA GCCTTCTGAG
    TAGTTGGGGC TACAGGTGTG CACCACCATG CCCAGCTCAT
    TTATTTTGTA ATTGTAGGGA CAGGGTCTCA CTGTGTTGCC
    TAGGCTGGTC TCAAGTGATC CTCCCTCCTT GGCCTCCCAA
    GGTGCTGGAA TTATAGGTGT GAACAAACCA AAAAAAAAAA
    AAA
    HPRT1 NM_000194.2 GGCGGGGCCT GCTTCTCCTC AGCTTCAGGC GGCTGCGACG 56
    AGCCCTCAGG CGAACCTCTC GGCTTTCCCG CGCGGCGCCG
    CCTCTTGCTG CGCCTCCGCC TCCTCCTCTG CTCCGCCACC
    GGCTTCCTCC TCCTGAGCAG TCAGCCCGCG CGCCGGCCGG
    CTCCGTTATG GCGACCCGCA GCCCTGGCGT CGTGATTAGT
    GATGATGAAC CAGGTTATGA CCTTGATTTA TTTTGCATAC
    CTAATCATTA TGCTGAGGAT TTGGAAAGGG TGTTTATTCC
    TCATGGACTA ATTATGGACA GGACTGAACG TCTTGCTCGA
    GATGTGATGA AGGAGATGGG AGGCCATCAC ATTGTAGCCC
    TCTGTGTGCT CAAGGGGGGC TATAAATTCT TTGCTGACCT
    GCTGGATTAC ATCAAAGCAC TGAATAGAAA TAGTGATAGA
    TCCATTCCTA TGACTGTAGA TTTTATCAGA CTGAAGAGCT
    ATTGTAATGA CCAGTCAACA GGGGACATAA AAGTAATTGG
    TGGAGATGAT CTCTCAACTT TAACTGGAAA GAATGTCTTG
    ATTGTGGAAG ATATAATTGA CACTGGCAAA ACAATGCAGA
    CTTTGCTTTC CTTGGTCAGG CAGTATAATC CAAAGATGGT
    CAAGGTCGCA AGCTTGCTGG TGAAAAGGAC CCCACGAAGT
    GTTGGATATA AGCCAGACTT TGTTGGATTT GAAATTCCAG
    ACAAGTTTGT TGTAGGATAT GCCCTTGACT ATAATGAATA
    CTTCAGGGAT TTGAATCATG TTTGTGTCAT TAGTGAAACT
    GGAAAAGCAA AATACAAAGC CTAAGATGAG AGTTCAAGTT
    GAGTTTGGAA ACATCTGGAG TCCTATTGAC ATCGCCAGTA
    AAATTATCAA TGTTCTAGTT CTGTGGCCAT CTGCTTAGTA
    GAGCTTTTTG CATGTATCTT CTAAGAATTT TATCTGTTTT
    GTACTTTAGA AATGTCAGTT GCTGCATTCC TAAACTGTTT
    ATTTGCACTA TGAGCCTATA GACTATCAGT TCCCTTTGGG
    CGGATTGTTG TTTAACTTGT AAATGAAAAA ATTCTCTTAA
    ACCACAGCAC TATTGAGTGA AACATTGAAC TCATATCTGT
    AAGAAATAAA GAGAAGATAT ATTAGTTTTT TAATTGGTAT
    TTTAATTTTT ATATATGCAG GAAAGAATAG AAGTGATTGA
    ATATTGTTAA TTATACCACC GTGTGTTAGA AAAGTAAGAA
    GCAGTCAATT TTCACATCAA AGACAGCATC TAAGAAGTTT
    TGTTCTGTCC TGGAATTATT TTAGTAGTGT TTCAGTAATG
    TTGACTGTAT TTTCCAACTT GTTCAAATTA TTACCAGTGA
    ATCTTTGTCA GCAGTTCCCT TTTAAATGCA AATCAATAAA
    TTCCCAAAAA TTTAAAAAAA AAAAAAAAAA AAAAA
    • Definitions
  • The articles “a” and “an” are used in this disclosure to refer to one or more than one (i.e., to at least one) of the grammatical object of the article. By way of example, “an element” means one element or more than one element.
  • The term “and/or” is used in this disclosure to mean either “and” or “or” unless indicated otherwise.
  • As used herein, the terms “polynucleotide” and “nucleic acid molecule” are used interchangeably to mean a polymeric form of nucleotides of at least 10 bases or base pairs in length, either ribonucleotides or deoxynucleotides or a modified form of either type of nucleotide, and is meant to include single and double stranded forms of DNA. As used herein, a nucleic acid molecule or nucleic acid sequence that serves as a probe in a microarray analysis preferably comprises a chain of nucleotides, more preferably DNA and/or RNA. In other embodiments, a nucleic acid molecule or nucleic acid sequence comprises other kinds of nucleic acid structures such a for instance a DNA/RNA helix, peptide nucleic acid (PNA), locked nucleic acid (LNA) and/or a ribozyme. Hence, as used herein the term “nucleic acid molecule” also encompasses a chain comprising non-natural nucleotides, modified nucleotides and/or non-nucleotide building blocks which exhibit the same function as natural nucleotides.
  • As used herein, the terms “hybridize,” “hybridizing”, “hybridizes,” and the like, used in the context of polynucleotides, are meant to refer to conventional hybridization conditions, such as hybridization in 50% formamide/6×SSC/0.1% SDS/100 μg/ml ssDNA, in which temperatures for hybridization are above 37 degrees and temperatures for washing in 0.1×SSC/0.1% SDS are above 55 degrees C., and preferably to stringent hybridization conditions.
  • As used herein, the term “normalization” or “normalizer” refers to the expression of a differential value in terms of a standard value to adjust for effects which arise from technical variation due to sample handling, sample preparation, and measurement methods rather than biological variation of biomarker concentration in a sample. For example, when measuring the expression of a differentially expressed protein, the absolute value for the expression of the protein can be expressed in terms of an absolute value for the expression of a standard protein that is substantially constant in expression.
  • The terms “diagnosis” and “diagnostics” also encompass the terms “prognosis” and “prognostics”, respectively, as well as the applications of such procedures over two or more time points to monitor the diagnosis and/or prognosis over time, and statistical modeling based thereupon. Furthermore, the term diagnosis includes: a. prediction (determining if a patient will likely develop aggressive disease (hyperproliferative/invasive)), b. prognosis (predicting whether a patient will likely have a better or worse outcome at a pre-selected time in the future), c. therapy selection, d. therapeutic drug monitoring, and e. relapse monitoring.
  • The term “providing” as used herein with regard to a biological sample refers to directly or indirectly obtaining the biological sample from a subject. For example, “providing” may refer to the act of directly obtaining the biological sample from a subject (e.g., by a blood draw, tissue biopsy, lavage and the like). Likewise, “providing” may refer to the act of indirectly obtaining the biological sample. For example, providing may refer to the act of a laboratory receiving the sample from the party that directly obtained the sample, or to the act of obtaining the sample from an archive.
  • “Accuracy” refers to the degree of conformity of a measured or calculated quantity (a test reported value) to its actual (or true) value. Clinical accuracy relates to the proportion of true outcomes (true positives (TP) or true negatives (TN) versus misclassified outcomes (false positives (FP) or false negatives (FN)), and may be stated as a sensitivity, specificity, positive predictive values (PPV) or negative predictive values (NPV), or as a likelihood, odds ratio, among other measures.
  • The term “biological sample” as used herein refers to any sample of biological origin potentially containing one or more biomarkers. Examples of biological samples include tissue, organs, or bodily fluids such as whole blood, plasma, serum, tissue, lavage or any other specimen used for detection of disease.
  • The term “subject” as used herein refers to a mammal, preferably a human.
  • “Treating” or “treatment” as used herein with regard to a condition may refer to preventing the condition, slowing the onset or rate of development of the condition, reducing the risk of developing the condition, preventing or delaying the development of symptoms associated with the condition, reducing or ending symptoms associated with the condition, generating a complete or partial regression of the condition, or some combination thereof.
  • Biomarker levels may change due to treatment of the disease. The changes in biomarker levels may be measured by the present disclosure. Changes in biomarker levels may be used to monitor the progression of disease or therapy.
  • “Altered”, “changed” or “significantly different” refer to a detectable change or difference from a reasonably comparable state, profile, measurement, or the like. Such changes may be all or none. They may be incremental and need not be linear. They may be by orders of magnitude. A change may be an increase or decrease by 1%, 5%, 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, 90%, 95%, 99%, 100%, or more, or any value in between 0% and 100%. Alternatively, the change may be 1-fold, 1.5-fold, 2-fold, 3-fold, 4-fold, 5-fold or more, or any values in between 1-fold and five-fold. The change may be statistically significant with a p value of 0.1, 0.05, 0.001, or 0.0001.
  • The term “stable disease” refers to a diagnosis for the presence of a melanoma, however the melanoma has been treated and remains in a stable condition, i.e. one that that is not progressive, as determined by imaging data and/or best clinical judgment.
  • The term “progressive disease” refers to a diagnosis for the presence of a highly active state of a melanoma, i.e. one has not been treated and is not stable or has been treated and has not responded to therapy, or has been treated and active disease remains, as determined by imaging data and/or best clinical judgment.
    • EXAMPLES
  • The disclosure is further illustrated by the following examples, which are not to be construed as limiting this disclosure in scope or spirit to the specific procedures herein described. It is to be understood that the examples are provided to illustrate certain embodiments and that no limitation to the scope of the disclosure is intended thereby. It is to be further understood that resort may be had to various other embodiments, modifications, and equivalents thereof which may suggest themselves to those skilled in the art without departing from the spirit of the present disclosure and/or scope of the appended claims.
    • Example 1
  • Derivation of a 28-Marker Gene Panel
  • Raw probe intensities (n=6,892,960 features) from n=49 whole blood samples were used to identify genes that best discriminated between different types of melanoma samples e.g., treated versus untreated, simultaneously. A total of 28 transcripts were identified in an unbiased manner as potential markers of melanoma behavior (Table 2).
  • An artificial intelligence model of melanoma disease dynamics was built using normalized gene expression of these 28 markers in whole blood from Controls (n=90), Responders/Stable (n=68), and Progressive (n=66) samples. The dataset was randomly split into training (n=169) and testing (n=55) partitions for model creation and validation respectively. Five algorithms (XGB, RF, TreeBag, SVM, NNET) were identified that best predicted the training data. In the test set, each algorithm produced probability scores that predicted the sample. Each probability score reflects the “certainty” of an algorithm that an unknown sample belongs to Control, Responder/Stable or Progressive class. For example, an unknown sample 51 can have the following probability vector {Control=20, Responder=50, Progressive=30}. This sample would be considered a responder, given a score of 50, but there may be potential of progression (probability of 30) (FIG. 1).
  • TABLE 2
    Amplicon produced
    Chromosome using forward and Assay Exon
    Melanoma Biomarker or Housekeeping Gene location UniGene reverse primers Loca- Bound-
    Symbol Name [Cytogenetic band] ID RefSeq Length (bp) tion ary
    ATL1 atlastin GTPase 1 Chr.14: Hs.584905 NM_001127713.1 65 1544 12-13
    50533082-50633068
    [14q22.1]
    ATP6V0D ATPase H+ transporting V0 Chr.16: Hs.106876 NM_004691.4 72 224 1-2
    subunit d1 67438014-67481186
    [16q22.1]
    C1ORF21 chromosome 1 open Chr.1: Hs.497159 NM_030806.3 84 805 5-6
    reading frame 21 184387016-184629021
    [1q25.3]
    CFLAR CASP8 and FADD like Chr.2: Hs.390736 NM_001127183.2 59 874 3-4
    apoptosis regulator 201116015-201172688
    [2q33.1]
    CFLAR-AS1 CFLAR antisense RNA 1 Chr.2: Hs.664613 NR_040030.1 103 883 6-7
    201140289-201157792
    [2q33.1]
    CHP1 calcineurin like EF-hand Chr.15: Hs.406234 NM_007236.4 120 212 1-2
    protein 1 41231149-41281887
    [15q15.1 ]
    DDX55 DEAD-box helicase 55 Chr.12: Hs.286173 NM_020936.2 74 183 1-2
    123602077-123620943
    [12q24.31]
    DMD dystrophin Chr.X: Hs.495912 NM_000109.3 76 9607 63-64
    31119219-33339609
    [Xp21.1]
    DNAJC9 DnaJ heat shock protein Chr.10: Hs.408577 NM_015190.4 102 198 1-1
    family (Hsp40) member C9 73241954-73247331
    [10q22.2]
    ENOSF1 enolase superfamily Chr.18: Hs.658550 NM_001126123.3 110 X 13-14
    member 1 670012-712664
    [18p11.32]
    FANCL Fanconi anemia Chr.2: Hs.631890 NM_001114636.1 138 540 6-7
    complementation group L 58159243-58241380
    [2p16.1]
    HJURP Holliday junction Chr.2: Hs.532968 NM_018410.4 52 399 4-5
    recognition protein 233836701-233854566
    [2q37.1]
    HLA-DOA major histocompatibility Chr.6: Hs.631991 NM_002119.3 124 160 1-2
    complex, class II, DO alpha 33004182-33009612
    [6p21.32]
    HLA-DRA major histocompatibility Chr.6: Hs.520048 NM_019111.4 129 884 4-5
    complex, class II, DR alpha 32439842-32445046
    [6p21.32]
    HNRNPA3P1 heterogeneous nuclear Chr.10: Hs.632956 NR_002726.2 99 2455 1-1
    ribonucleoprotein A3 43787412-43790417
    pseudogene 1 [10q11.21]
    IL23A interleukin 23 subunit alpha Chr.12: Hs.382212 NM_016584.2 107 323 1-2
    56334159-56340410
    [12q13.3]
    IQGAP1 IQ motif containing Chr.15: Hs.430551 NM_003870.3 69 4562 34-35
    GTPase 90388241-90502243
    activating protein 1 [15q26.1]
    LOC494127 NFYC pseudogene Chr.9: Hs.626316 NR_036691.1 86 150 1-1
    87083886-87085225
    [9q21.33]
    LOC646471 uncharacterized Chr.1: Hs.727271 NR_024498.1 80 2858 1-1
    LOC646471 25819954-25823606
    [1p36.11]
    LOH12CR loss of heterozygosity, 12, Chr.12: Hs.67553 NR_024061.1 69 140 1-2
    chromosomal region 2 12355408-12357067
    (non-protein coding) [12p13.2]
    MTRNR2L2_MTO1 CUSTOM PRIMER
    PBXIP1 PBX homeobox interacting Chr.1: Hs.505806 NM_020524.3 60 189 2-3
    protein 1 154944080-154956163
    [1q21.3]
    RNF5 ring finger protein 5 Chr.6: Hs.731774 NM_006913.3 67 273 1-2
    32178385-32180793
    [6p21.32]
    SERTAD2 SERTA domain containing Chr.2: Hs.591569 NM_014755.2 91 288 1-2
    2 64631621-64751091
    [2p14]
    SLC35G5 solute carrier family 35 Chr.8: Hs.458397 NM_054028.1 144 541 1-1
    member G5 11330986-11332186
    [8p23.1]
    SPATS2L spermatogenesis associated Chr.2: Hs.120323 NM_001100422.1 89 1364 10-11
    serine rich 2 like 200305881-200482263
    [2q33.1]
    TDRD7 tudor domain containing Chr.9: Hs.193842 NM_001302884.1 59 3084 15-16
    7 97412020-97496125
    [9q22.33]
    TOX4 TOX high mobility group Chr.14: Hs.555910 NM_001303523.1 145 447 3-3
    (housekeeping box family member 4 21477176-21499177
    gene) [14q11.2]
    TPT1 tumor protein, Chr.13: Hs.374596 NM_001286272.1 131 377 3-3
    (housekeeping translationally-controlled 1 45333471-45341284
    gene) [13q14.13]
    TXK TXK tyrosine kinase Chr.4: Hs.479669 NM_003328.2 113 1265 11-12
    48066393-48135322
    [4p12 ]
    YY2 YY2 transcription factor Chr.X: Hs.673601 NM_206923.3 110 552 1-1
    21855987-21858727
    [Xp22.12]
  • Diagnosis: Identification of Samples as Melanoma
  • In the test set 1, the data for the utility of the test to differentiate melanoma from controls are included in Table 3. The metrics are included in FIG. 2. These are: sensitivity >90%, specificity 100%, PPV 100%, NPV 87%. The overall accuracy is 94%. The tool can therefore differentiate between controls and aggressive and stable melanoma disease.
  • TABLE 3
    Confusion matrix showing classification accuracy of
    the 5-model algorithm that determines whether a sample
    is a melanoma or a control in blood samples
    Predicted/Reference Melanoma Control
    Control
    3 20
    Melanoma 30 0
    Sensitivity 91%
    Specificity 100% 
    Positive Predictive Value 100% 
    Negative Predictive Value 87%
    Accuracy 94%
  • The test was evaluated in a second test set (test set 2) that included 74 controls and 92 melanoma patients. The mean Melanomx score in the melanoma group was 73±31 versus 10±8 in the control group (FIG. 3A). The receiver operator curve analysis demonstrated the score exhibited an area under the curve (AUC) of 0.96 (FIG. 3B) and the metrics were 88-100% (FIG. 3C).
  • Correlation with Surgical Removal of Melanoma.
  • In the surgical series (n=46), removal of melanoma decreased the score from 74±16 to 20±12 (FIG. 4A). Evaluation of the post-surgical group identified the score was significantly different between patients with no evidence of disease 13±6 (not different to the control group) and those with residual disease (33±9) (FIG. 4B). The Melanomx score can therefore define the extent of surgery and identify those who are surgical cures.
  • Evaluation of Immune-Therapy and Targeted (BRAF Inhibitor) Therapy.
  • In the therapy series (n=30), treatment with ipilimumab (immune therapy targeting CTLA-4), nivolumab (immune therapy targeting PD-1) or a BRAF inhibitor (vemurafenib) for 5 months significantly decreased the Melanomx scores from 88±12 to 15±5 (p<0.0001), 35±14 (p<0.001) and 38±21 (p<0.0001), respectively (FIG. 5). All patients in the treated groups were stable. This indicates that the Melanomx score can therefore be used to measure the efficacy of both immune and targeted-therapy in melanoma and that a decrease in score correlated with response to therapeutic intervention.
  • Confirmation that Gene Expression is Melanoma Derived.
  • We confirmed that melanoma was the source for the blood-based gene expression assay by evaluating expression in different melanoma cell lines, in tumor tissue and by comparing expression in blood with tumor tissue collected at the same time-point during surgery.
  • All 28 genes were highly expressed in all 3 melanoma cell lines. Scores ranged from 94±6 (Hs294T) to 82±5 (CHL) to 42±9 (A375) (FIG. 6A).
  • Spike-in experiments using these 3 cell lines and normal whole blood demonstrated that gene expression scores were detected when as few as 1 cell was spiked into 1 ml of blood. One single melanoma cell was detectable. Scores ranged from 21±4 (A375) to 30±5 (CHL) to 34±2 (H2294) (FIG. 6B). Scores were significantly elevated compared to control blood (no spike-in; p<0.0001).
  • We then evaluated gene expression in tumor tissue. All 28 genes were highly expressed in melanoma compared to matched normal tissue and scores were significantly elevated 70±20 versus 4±3 (p<0.0001) (FIG. 7A).
  • We also compared gene expression in tumor tissue and blood collected at the same time point. Gene expression was highly concordant (Pearson r: 0.74-0.83, median: 0.819) identifying gene expression in tumor tissue and blood was concordant (FIG. 7B).
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    EQUIVALENTS
  • While the present invention has been described in conjunction with the specific embodiments set forth above, many alternatives, modifications and other variations thereof will be apparent to those of ordinary skill in the art. All such alternatives, modifications and variations are intended to fall within the spirit and scope of the present invention.

Claims (35)

1. A method for detecting a melanoma in a subject in need thereof, comprising:
determining the expression level of at least 29 biomarkers from a test sample from the subject by contacting the test sample with a plurality of agents specific to detect the expression of the at least 29 biomarkers, wherein the at least 29 biomarkers comprise ATL1, ATP6V0D, C1ORF21, CFLAR, CFLAR-AS1, CHP1, DDX55, DMD, DNAJC9, ENOSF1, FANCL, HJURP, HLA-DOA, HLA-DRA, HNRNPA3P1, IL23A, IQGAP1, LOC494127, LOC646471, LOH12CR, PBXIP1, RNF5, SERTAD2, SLC35G5, SPATS2L, TDRD7, TXK, YY2, and at least one housekeeping gene;
normalizing the expression level of each of ATL1, ATP6V0D, C1ORF21, CFLAR, CFLAR-AS1, CHP1, DDX55, DMD, DNAJC9, ENOSF1, FANCL, HJURP, HLA-DOA, HLA-DRA, HNRNPA3P1, IL23A, IQGAP1, LOC494127, LOC646471, LOH12CR, PBXIP1, RNF5, SERTAD2, SLC35G5, SPATS2L, TDRD7, TXK, and YY2 to the expression level of the at least one housekeeping gene, thereby obtaining a normalized expression level of each of ATL1, ATP6V0D, C1ORF21, CFLAR, CFLAR-AS1, CHP1, DDX55, DMD, DNAJC9, ENOSF1, FANCL, HJURP, HLA-DOA, HLA-DRA, HNRNPA3P1, IL23A, IQGAP1, LOC494127, LOC646471, LOH12CR, PBXIP1, RNF5, SERTAD2, SLC35G5, SPATS2L, TDRD7, TXK, and YY2;
inputting each normalized expression level into an algorithm to generate a score;
comparing the score with a first predetermined cutoff value; and
producing a report, wherein the report identifies the presence of a melanoma in the subject when the score is equal to or greater than the first predetermined cutoff value or identifies the absence of a melanoma in the subject when the score is below the first predetermined cutoff value, wherein the first predetermined cutoff value is 20 on a scale of 0 to 100.
2. The method of claim 1, wherein the at least one housekeeping gene is selected from the group consisting of ALG9, SEPN, YWHAQ, VPS37A, PRRC2B, DOPEY2, NDUFB11, ND4, MRPL19, PSMC4, SF3A1, PUM1, ACTB, GAPD, GUSB, RPLPO, TFRC, MORF4L1, 18S, PPIA, PGK1, RPL13A, B2M, YWHAZ, SDHA, HPRT1, TOX4, and TPT1.
3. The method of claim 2, wherein the at least one housekeeping gene comprises TOX4 and TPT1.
4. The method of claim 3, wherein the normalized expression level is obtained by:
normalizing the expression level of each of ATL1, ATP6V0D, C1ORF21, CFLAR, CFLAR-AS1, CHP1, DDX55, DMD, DNAJC9, ENOSF1, FANCL, HJURP, HLA-DOA, HLA-DRA, HNRNPA3P1, IL23A, IQGAP1, LOC494127, LOC646471, LOH12CR, PBXIP1, RNF5, SERTAD2, SLC35G5, SPATS2L, TDRD7, TXK, and YY2 to the expression level of TOX4, thereby obtaining a first normalized expression level of each of ATL1, ATP6V0D, C1ORF21, CFLAR, CFLAR-AS1, CHP1, DDX55, DMD, DNAJC9, ENOSF1, FANCL, HJURP, HLA-DOA, HLA-DRA, HNRNPA3P1, IL23A, IQGAP1, LOC494127, LOC646471, LOH12CR, PBXIP1, RNF5, SERTAD2, SLC35G5, SPATS2L, TDRD7, TXK, and YY2;
normalizing the expression level of each of ATL1, ATP6V0D, C1ORF21, CFLAR, CFLAR-AS1, CHP1, DDX55, DMD, DNAJC9, ENOSF1, FANCL, HJURP, HLA-DOA, HLA-DRA, HNRNPA3P1, IL23A, IQGAP1, LOC494127, LOC646471, LOH12CR, PBXIP1, RNF5, SERTAD2, SLC35G5, SPATS2L, TDRD7, TXK, and YY2 to the expression level of TPT1, thereby obtaining a second normalized expression level of each of ATL1, ATP6V0D, C1ORF21, CFLAR, CFLAR-AS1, CHP1, DDX55, DMD, DNAJC9, ENOSF1, FANCL, HJURP, HLA-DOA, HLA-DRA, HNRNPA3P1, IL23A, IQGAP1, LOC494127, LOC646471, LOH12CR, PBXIP1, RNF5, SERTAD2, SLC35G5, SPATS2L, TDRD7, TXK, and YY2;
averaging the first normalized expression level and the second normalized expression level to obtain the normalized expression level.
5. The method of claim 1, having a sensitivity of greater than 90%.
6. The method of claim 1, having a specificity of greater than 90%.
7. The method of claim 1, wherein the melanoma is progressive.
8. The method of claim 1, wherein at least one of the at least 29 biomarkers is RNA, cDNA, or protein.
9. The method of claim 8, wherein when the biomarker is RNA, the RNA is reverse transcribed to produce cDNA, and the produced cDNA expression level is detected.
10. The method of claim 1, wherein the expression level of the biomarker is detected by forming a complex between the biomarker and a labeled probe or primer.
11. The method of claim 10, wherein when the biomarker is protein, the protein is detected by forming a complex between the protein and a labeled antibody.
12. The method of claim 11, wherein the label is a fluorescent label.
13. The method of claim 8, wherein when the biomarker is RNA or cDNA, the RNA or cDNA is detected by forming a complex between the RNA or cDNA and a labeled nucleic acid probe or primer.
14. The method of claim 13, wherein the label is a fluorescent label.
15. The method of claim 13, wherein the complex between the RNA or cDNA and the labeled nucleic acid probe or primer is a hybridization complex.
16. The method of any one of claims 1-15, wherein the test sample is blood, serum, plasma, or neoplastic tissue.
17. The method of claim 1, wherein the first predetermined cutoff value is derived from a plurality of reference samples obtained from subjects free of a neoplastic disease.
18. The method of claim 17, wherein each reference sample is blood, serum, plasma, or non-neoplastic tissue.
19. The method of claim 1, further comprising treating the subject identified as having a melanoma with surgery or drug therapy.
20. The method of claim 1, wherein the subject in need thereof is a subject diagnosed with a melanoma, a subject having at least one melanoma symptom, or a subject having a predisposition or familial history for developing a melanoma.
21. The method of claim 1, wherein a subject is human.
22. The method of claim 1, wherein the algorithm is XGB, RF, glmnet, cforest, CART, treebag, knn, nnet, SVM-radial, SVM-linear, NB, NNET, or mlp.
23. A method for determining whether a melanoma in a subject is stable or progressive, comprising:
determining the expression level of at least 29 biomarkers from a test sample from the subject by contacting the test sample with a plurality of agents specific to detect the expression of the at least 29 biomarkers, wherein the at least 29 biomarkers comprise ATL1, ATP6V0D, C1ORF21, CFLAR, CFLAR-AS1, CHP1, DDX55, DMD, DNAJC9, ENOSF1, FANCL, HJURP, HLA-DOA, HLA-DRA, HNRNPA3P1, IL23A, IQGAP1, LOC494127, LOC646471, LOH12CR, PBXIP1, RNF5, SERTAD2, SLC35G5, SPATS2L, TDRD7, TXK, YY2, and at least one housekeeping gene;
normalizing the expression level of each of ATL1, ATP6V0D, C1ORF21, CFLAR, CFLAR-AS1, CHP1, DDX55, DMD, DNAJC9, ENOSF1, FANCL, HJURP, HLA-DOA, HLA-DRA, HNRNPA3P1, IL23A, IQGAP1, LOC494127, LOC646471, LOH12CR, PBXIP1, RNF5, SERTAD2, SLC35G5, SPATS2L, TDRD7, TXK, and YY2 to the expression level of the at least one housekeeping gene, thereby obtaining a normalized expression level of each of ATL1, ATP6V0D, C1ORF21, CFLAR, CFLAR-AS1, CHP1, DDX55, DMD, DNAJC9, ENOSF1, FANCL, HJURP, HLA-DOA, HLA-DRA, HNRNPA3P1, IL23A, IQGAP1, LOC494127, LOC646471, LOH12CR, PBXIP1, RNF5, SERTAD2, SLC35G5, SPATS2L, TDRD7, TXK, and YY2;
inputting each normalized expression level into an algorithm to generate a score;
comparing the score with a second predetermined cutoff value; and
producing a report, wherein the report identifies that the melanoma is progressive when the normalized expression level is equal to or greater than the second predetermined cutoff value or identifies that the melanoma is stable when the normalized expression level is below the second predetermined cutoff value, wherein the second predetermined cutoff value is 50 on a scale of 0 to 100.
24. The method of claim 23, wherein the at least one housekeeping gene is selected from the group consisting of ALG9, SEPN, YWHAQ, VPS37A, PRRC2B, DOPEY2, NDUFB11, ND4, MRPL19, PSMC4, SF3A1, PUM1, ACTB, GAPD, GUSB, RPLPO, TFRC, MORF4L1, 18S, PPIA, PGK1, RPL13A, B2M, YWHAZ, SDHA, HPRT1, TOX4, and TPT1.
25. The method of claim 24, wherein the at least one housekeeping gene comprises TOX4 and TPT1.
26. A method for evaluating the extent of surgical resection in a subject having a melanoma, comprising:
determining the expression level of at least 29 biomarkers from a test sample from the subject after the surgical resection by contacting the test sample with a plurality of agents specific to detect the expression of the at least 29 biomarkers, wherein the at least 29 biomarkers comprise ATL1, ATP6V0D, C1ORF21, CFLAR, CFLAR-AS1, CHP1, DDX55, DMD, DNAJC9, ENOSF1, FANCL, HJURP, HLA-DOA, HLA-DRA, HNRNPA3P1, IL23A, IQGAP1, LOC494127, LOC646471, LOH12CR, PBXIP1, RNF5, SERTAD2, SLC35G5, SPATS2L, TDRD7, TXK, YY2, and at least one housekeeping gene;
normalizing the expression level of each of ATL1, ATP6V0D, C1ORF21, CFLAR, CFLAR-AS1, CHP1, DDX55, DMD, DNAJC9, ENOSF1, FANCL, HJURP, HLA-DOA, HLA-DRA, HNRNPA3P1, IL23A, IQGAP1, LOC494127, LOC646471, LOH12CR, PBXIP1, RNF5, SERTAD2, SLC35G5, SPATS2L, TDRD7, TXK, and YY2 to the expression level of the at least one housekeeping gene, thereby obtaining a normalized expression level of each of ATL1, ATP6V0D, C1ORF21, CFLAR, CFLAR-AS1, CHP1, DDX55, DMD, DNAJC9, ENOSF1, FANCL, HJURP, HLA-DOA, HLA-DRA, HNRNPA3P1, IL23A, IQGAP1, LOC494127, LOC646471, LOH12CR, PBXIP1, RNF5, SERTAD2, SLC35G5, SPATS2L, TDRD7, TXK, and YY2;
inputting each normalized expression level into an algorithm to generate a score;
comparing the score with a third predetermined cutoff value; and
producing a report, wherein the report identifies that the surgical resection does not remove the entire melanoma when the normalized expression level is equal to or greater than the third predetermined cutoff value or identifies that the surgical resection removes the entire melanoma when the normalized expression level is below the third predetermined cutoff value, wherein the third predetermined cutoff value is 20 on a scale of 0 to 100.
27. The method of claim 26, wherein the report further identifies that the risk of melanoma recurrence is high when the normalized expression level is equal to or greater than the third predetermined cutoff value or identifies that the risk of melanoma recurrence is low when the normalized expression level is below the third predetermined cutoff value.
28. The method of claim 26, wherein the at least one housekeeping gene is selected from the group consisting of ALG9, SEPN, YWHAQ, VPS37A, PRRC2B, DOPEY2, NDUFB11, ND4, MRPL19, PSMC4, SF3A1, PUM1, ACTB, GAPD, GUSB, RPLPO, TFRC, MORF4L1, 18S, PPIA, PGK1, RPL13A, B2M, YWHAZ, SDHA, HPRT1, TOX4, and TPT1.
29. The method of claim 28, wherein the at least one housekeeping gene comprises TOX4 and TPT1.
30. A method for determining a response by a subject having a melanoma to a therapy, comprising:
determining a first expression level of at least 28 biomarkers from a first test sample from the subject at a first time point by contacting the first test sample with a plurality of agents specific to detect the expression of the at least 28 biomarkers, wherein the 28 biomarkers comprise ATL1, ATP6V0D, C1ORF21, CFLAR, CFLAR-AS1, CHP1, DDX55, DMD, DNAJC9, ENOSF1, FANCL, HJURP, HLA-DOA, HLA-DRA, HNRNPA3P1, IL23A, IQGAP1, LOC494127, LOC646471, LOH12CR, PBXIP1, RNF5, SERTAD2, SLC35G5, SPATS2L, TDRD7, TXK, and YY2;
determining a second expression level of the at least 28 biomarkers from a second test sample from the subject at a second time point by contacting the second test sample with a plurality of agents specific to detect the expression of the at least 28 biomarkers, wherein the second time point is after the first time point and after the administration of the therapy to the subject;
comparing the first expression level with the second expression level; and
producing a report, wherein the report identifies that the subject is responsive to the therapy when the second expression level is significantly decreased as compared to the first expression level.
31. The method of claim 30, wherein the first time point is prior to the administration of the therapy to the subject.
32. The method of claim 30, wherein the first time point is after the administration of the therapy to the subject.
33. The method of claim 30, wherein the therapy comprises an immunotherapy.
34. The method of claim 30, wherein the therapy comprises a targeted therapy.
35. The method of claim 34, wherein the targeted therapy comprises a BRAF inhibitor.
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