KR20220008244A - Age-specific markers for diagnosing prognosis and determining treatment stratagies of patient of Prostate adenocarcinoma - Google Patents

Abstract

The present invention relates to a marker for diagnosing the difference in the treatment effect and the prognosis of prostate cancer depending on the age of prostate cancer patients. The mutation of the gene of the present invention and the survival rate or recurrence rate of prostate cancer patients of a certain age are correlated with one another, so that the mutated gene of the present invention can be used as a marker for predicting the difference in the treatment effect of prostate cancer or the prognosis of prostate cancer patients on the basis of age.

Description

Age-specific markers for diagnosing prognosis and determining treatment stratagies of patient of Prostate adenocarcinoma}

The present invention provides information necessary for prognostic diagnosis and treatment strategy determination of prostate cancer using an age-specific marker for prognosis diagnosis of prostate cancer patients, a kit for prognosis diagnosis of a prostate cancer patient including the same, and a prognostic diagnosis marker for a prostate cancer patient. how to provide it.

As one of the male reproductive organs, the prostate is a body organ that makes and secretes a part of the liquid component of semen. It is composed of a middle lobe and two lateral lobes, a part consists of glandular tissue, and a part consists of muscle fibers and surrounds the urethra. When the prostate enlarges, the urethra becomes narrow, making it difficult for urine to pass through. Prostate cancer is also found with the same symptoms.

Prostate cancer is a malignant tumor that occurs in the prostate. Age, race, and family history are considered to be the most important causes, and hormones, dietary habits, and chemicals are also known to act as important factors in the pathogenesis. According to data from the Central Cancer Registry in 2019, prostate cancer ranked 7th among all cancers and 4th among cancers occurring in men, and the incidence rate in Korea is increasing.

The diagnosis of prostate cancer is made by combining all findings after performing digital rectal examination, blood prostate-specific antigen (PSA) test, transrectal ultrasound, and imaging. In the early stages of prostate cancer, the cancer does not spread to the surrounding area, so treatment is effective, but it becomes an incurable disease after it progresses, so early diagnosis is very important.

Treatment methods for prostate cancer include observational therapy, curative surgery, radiation therapy, hormone therapy, and chemotherapy, and are determined by considering related factors such as stage, tumor differentiation, and patient's age and health status. When prostate cancer is diagnosed at the local cancer stage, the cure rate is high, but when it is detected after the advanced stage, the cure rate drops significantly. If the level of prostate-specific antigen (PSA) in the blood increases in the follow-up test after treatment even after a cure, it is found to be a biochemical recurrence of prostate cancer. Years later, clinical relapse occurs. However, biochemical recurrence does not necessarily lead to clinical recurrence, and even if clinical recurrence occurs, the timing varies greatly. In addition, the clinical course after curative treatment for localized prostate cancer has not been clearly clarified, so a treatment policy for biochemical recurrence has not been established.

Age is estimated to be one of the biggest factors in the development of prostate cancer. The age of prostate cancer patients will influence the choice of treatment method. Although several biomarkers for the diagnosis of prostate cancer have been disclosed (Patent Registration No. 10-1778036), markers that can measure the prognosis of patients with prostate cancer, in particular, genetic mutations found in prostate cancer and the age and The relationship between the two has not been studied yet.

In order to apply an appropriate therapeutic strategy for prostate cancer patients, it is necessary to develop markers that predict the prognosis of prostate cancer patients and help determine treatment strategies.

An object of the present invention is to provide a marker that helps in prognostic diagnosis and treatment strategy determination of a prostate cancer patient based on the prostate cancer patient's age.

In order to achieve the above object, one aspect of the present invention provides a composition for predicting treatment effect or prognosis diagnosis according to the age of a prostate cancer patient, comprising an agent capable of detecting a mutation in a gene encoding ASPH, ITPR1 and SHISAL1 to provide.

Another aspect of the present invention provides a kit for predicting treatment effect or prognosis diagnosis according to the age of a prostate cancer patient comprising the composition.

Another aspect of the present invention comprises the steps of preparing a sample DNA from a sample of a prostate cancer patient of known age;

amplifying the sample DNA using the kit;

determining the presence or absence of an age-specific marker from the amplification result;

Treating a prostate cancer patient whose age-specific markers have been identified with any prostate cancer treatment candidate or by any method; and

Prostate comprising a; prostate cancer comprising the step of adopting any candidate material or treatment method for improving or treating prostate cancer, suitable for the age group of prostate cancer patients for whom age-specific markers have been identified Provided is a method for providing information necessary for determining the difference in the treatment effect of prostate cancer according to the age of cancer patients.

Another aspect of the present invention comprises the steps of preparing a sample DNA from a sample of a prostate cancer patient;

amplifying the sample DNA using the kit; and

It provides a method of providing information necessary for prognostic diagnosis of prostate cancer according to the age of a prostate cancer patient, including the step of confirming the presence or absence of an age-specific marker from the amplification result.

Mutations of the genes encoding ASPH, ITPR1 and SHISAL1, which are the mutant genes discovered in the present invention, or ABCC10, ACTL6A, ADARB2, ANKRD30B, ARHGAP10, ATRNL1, C11orf24, CAMKK1, CD14, CELF3, CLCN2, CLIP4, Genes selected from the group consisting of CRIM1, CXorf56, CYP4F11, DYTN, FIGNL1, FOXE1, FSCN2, FTMT, PI4KB, GLYCTK, GLYR1, INTU, POGLUT2, KDM4B, KIAA0355, KIRREL2, KLKB1, KRT37, LETMD1, MAML2, MAP1B and METTL2 Since the mutation of at least one gene is correlated with the age of the prostate cancer patient, the difference in the prostate cancer treatment effect and the survival rate according to the age of the prostate cancer patient can be predicted by determining whether the gene is mutated.

In addition, mutations in the genes encoding ASPH, ITPR1 and SHISAL1, which are the mutant genes discovered in the present invention, or ABCC10, ACTL6A, ADARB2, ANKRD30B, ARHGAP10, ATRNL1, C11orf24, CAMKK1, CD14, CELF3, CLCN2, CLIP4 in addition to the mutant genes , CRIM1, CXorf56, CYP4F11, DYTN, FIGNL1, FOXE1, FSCN2, FTMT, PI4KB, GLYCTK, GLYR1, INTU, POGLUT2, KDM4B, KIAA0355, KIRREL2, KLKB1, KRT37, LETMD1 selected from the AML METTL1 gene family consisting of Since the mutation of one gene, the survival rate of prostate cancer patients of a specific age, or the mutation of the gene and the recurrence rate of prostate cancer are each correlated, the mutation of the genes of the present invention is used as a marker to predict the prognosis of prostate cancer patients. can be used

However, the effects of the present invention are not limited to the above-mentioned effects, and other effects not mentioned will be clearly understood by those skilled in the art from the following description.

1 shows 78 age-specific mutant genes identified through comparative analysis of age groups I, II, III and IV.
2 shows 13 age-specific mutant genes identified through comparative analysis of age groups I and II+III+IV.
3 is a view showing nine age-specific mutant genes identified through comparative analysis of age groups I + II and III + IV.
4 shows 98 age-specific mutated genes identified through comparative analysis of age groups I+II+III and IV.
5 to 41 show the total survival rate or disease-free survival rate of a prostate cancer patient with a mutation in the corresponding gene (red) and a prostate cancer patient without a mutation in the corresponding gene (blue) for each age-specific and survival-specific gene. is a graph about

Prostate adenocarcinoma (PRAD) reported to The Cancer Genome Atlas (TCGA) in order to discover age-specific markers for differential diagnosis, treatment strategy determination, or prognosis of prostate cancer based on the age difference of prostate cancer patients Machine learning using data was implemented. As a result, an age-specific mutant gene and a survival-specific mutant gene for prostate cancer were found, respectively, and 37 age-specific and survival-specific markers for prostate cancer were discovered.

Hereinafter, the present invention will be described in detail.

1. Age-specific mutated gene in prostate cancer patients

One aspect of the present invention is to provide a composition for predicting treatment effect or prognosis diagnosis according to the age of a prostate cancer patient, comprising an agent capable of detecting a mutation in a gene encoding ASPH, ITPR1 and SHISAL1.

In one embodiment of the present invention, the diagnostic composition is ABCC10, ACTL6A, ADARB2, ANKRD30B, ARHGAP10, ATRNL1, C11orf24, CAMKK1, CD14, CELF3, CLCN2, CLIP4, CRIM1, CXorf56, CYP4F11, DYTN, FIG1F11, FOXE, FIGNL1 An agent capable of detecting a mutation in a gene encoding at least one selected from the group consisting of FTMT, PI4KB, GLYCTK, GLYR1, INTU, POGLUT2, KDM4B, KIAA0355, KIRREL2, KLKB1, KRT37, LETMD1, MAML2, MAP1B and METTL9 Further, it may be a composition for predicting treatment effect or prognosis diagnosis according to the age of a prostate cancer patient.

In another embodiment of the present invention, the mutation in the gene encoding ASPH is a missense mutation that is at least one of A382V and V676M in the amino acid sequence of SEQ ID NO: 1;

The mutation of the gene encoding ITPR1 is at least one missense mutation selected from the group consisting of C2395Y, G2146R and A597T in the amino acid sequence of SEQ ID NO: 2, or A1894Lfs*8 frame shift deletion (frame shift delete, FS del ) is a mutation;

The mutation of the gene encoding SHISAL1 is a missense mutation that is one of R29W and L117V in the amino acid sequence of SEQ ID NO: 3; In, it may be a composition for predicting treatment effect or prognosis diagnosis according to the age of a prostate cancer patient.

In another embodiment of the present invention, the mutation of the gene encoding ABCC10 is a missense mutation of at least one of R570Q and E593Q, or a nonsense mutation of R545* in the amino acid sequence of SEQ ID NO: 4;

The mutation in the gene encoding ACTL6A is a missense mutation that is at least one of R76H and G26D in the amino acid sequence of SEQ ID NO: 5;

the mutation of the gene encoding ADARB2 is at least one missense mutation selected from the group consisting of A703V, R520H and L480P in the amino acid sequence of SEQ ID NO: 6;

the mutation of the gene encoding ANKRD30B is at least one missense mutation selected from the group consisting of D570Y, S574F and I1058T in the amino acid sequence of SEQ ID NO: 7;

The mutation in the gene encoding ARHGAP10 is a missense mutation of E195D or a splice mutation of X464_splice in the amino acid sequence of SEQ ID NO: 8;

The mutation in the gene encoding ATRNL1 is a missense mutation that is at least one of E905K and H313Y in the amino acid sequence of SEQ ID NO: 9;

The mutation in the gene encoding C11orf24 is a missense mutation that is A395V in the amino acid sequence of SEQ ID NO: 10;

The mutation of the gene encoding CAMKK1 is a missense mutation that is at least one of A201V and V238I in the amino acid sequence of SEQ ID NO: 11;

The mutation of the gene encoding CD14 is a missense mutation that is at least one of R33C and A375T in the amino acid sequence of SEQ ID NO: 12;

The mutation of the gene encoding CELF3 is a missense mutation that is A245T or a mutation that is a frame shift delete (FS del) that is S260Afs*167 in the amino acid sequence of SEQ ID NO: 13;

The mutation of the gene encoding CLCN2 is a missense mutation that is at least one of R646Q and G199R in the amino acid sequence of SEQ ID NO: 14;

The mutation of the gene encoding CLIP4 is a missense mutation that is at least one of S55L and R673H in the amino acid sequence of SEQ ID NO: 15;

the mutation in the gene encoding CRIM1 is a missense mutation that is at least one of D352G and S313C in the amino acid sequence of SEQ ID NO: 16;

the mutation of the gene encoding CXorf56 is a missense mutation that is at least one of E150K and T115M in the amino acid sequence of SEQ ID NO: 17;

the mutation of the gene encoding CYP4F11 is a missense mutation that is at least one of R515W and T152M in the amino acid sequence of SEQ ID NO: 18;

The mutation of the gene encoding DYTN is a missense mutation of W209R or a nonsense mutation of Q470* in the amino acid sequence of SEQ ID NO: 19;

the mutation in the gene encoding FIGNL1 is a frame shift deletion mutation that is at least one of K326Sfs*3 and E64Rfs*16 in the amino acid sequence of SEQ ID NO: 20;

The mutation of the gene encoding FOXE1 is an in-frame delete (IF del) mutation that is A178_A179del in the amino acid sequence of SEQ ID NO: 21;

The mutation in the gene encoding FSCN2 is a missense mutation that is at least one of V261L and T244M in the amino acid sequence of SEQ ID NO: 22;

The mutation in the gene encoding FTMT is a missense mutation that is at least one of R23C and R20H in the amino acid sequence of SEQ ID NO: 23;

The mutation in the gene encoding PI4KB is a missense mutation that is at least one of C406F and M223I in the amino acid sequence of SEQ ID NO: 24;

The mutation of the gene encoding GLYCTK is at least one of A142V and T466S in the amino acid sequence of SEQ ID NO: 25;

the mutation of the gene encoding GLYR1 is at least one mutation selected from the group consisting of T205A, R171W and P184L in the amino acid sequence of SEQ ID NO: 26;

The mutation of the gene encoding the INTU is a frame shift insert (FS ins) mutation of D229Vfs*7 or a missense mutation of R705C in the amino acid sequence of SEQ ID NO: 27;

The mutation of the gene encoding POGLUT2 is a missense mutation that is one of H191Q and H251N in the amino acid sequence of SEQ ID NO: 28;

The mutation in the gene encoding KDM4B is a missense mutation that is at least one of I256V and V66M, a frame shift insertion mutation that is N103Kfs*14, or a splice mutation that is D145= in the amino acid sequence of SEQ ID NO: 29;

The mutation of the gene encoding KIAA0355 is at least one mutation selected from the group consisting of A311T, R16H and A280V in the amino acid sequence of SEQ ID NO: 30, or a nonsense mutation that is Q345*;

The mutation of the gene encoding KIRREL2 is a missense mutation that is at least one of P22L and L61Q in the amino acid sequence of SEQ ID NO: 31;

the mutation of the gene encoding KLKB1 is a missense mutation that is at least one of R390H and D114Y in the amino acid sequence of SEQ ID NO: 32;

The mutation in the gene encoding KRT37 is a missense mutation that is at least one of A217T and N287D in the amino acid sequence of SEQ ID NO: 33;

The mutation in the gene encoding LETMD1 is a missense mutation that is at least one of V84A and Q301H in the amino acid sequence of SEQ ID NO: 34;

The mutation of the gene encoding MAML2 is a missense mutation that is at least one of P1120S and P1022S in the amino acid sequence of SEQ ID NO: 35;

the mutation of the gene encoding MAP1B is a missense mutation that is at least one of R1275H and G1185R in the amino acid sequence of SEQ ID NO: 36;

The mutation of the gene encoding METTL9 is a missense mutation that is at least one of V307I and P165L in the amino acid sequence of SEQ ID NO: 37; In, it may be a composition for predicting treatment effect or prognosis diagnosis according to the age of a prostate cancer patient.

Gene bank accession numbers of the genes are ASPH (Gene bank accession number: NM_004318.4), ITPR1 (Gene bank accession number: NM_002222.6), SHISAL1 (Gene bank accession number: NM_001099294.2), ABCC10 (Gene bank accession), respectively. number: NM_001198934.2), ACTL6A (Gene bank accession number: NM_004301.5), ADARB2 (Gene bank accession number: NM_018702.4), ANKRD30B (Gene bank accession number: NM_001145029.1), ARHGAP10 (Gene bank accession number: NM_024605.4), ATRNL1 (Gene bank accession number: NM_207303.4), C11orf24 (Gene bank accession number: NM_001300913.2), CAMKK1 (Gene bank accession number: NM_032294.3), CD14 (Gene bank accession number: NM_000591). 4), CELF3 (Gene bank accession number: NM_007185.7), CLCN2 (Gene bank accession number: NM_004366.6), CLIP4 (Gene bank accession number: NM_001287527.2), CRIM1 (Gene bank accession number: NM_016441.3) , CXorf56 (Gene bank accession number: NM_022101.4), CYP4F11 (Gene bank accession number: NM_001128932.1), DYTN (Gene bank accession number: NM_001093730.1), FIGNL1 (Gene bank accession number: NM_001042762.4), FOXE1 (Gene bank accession number: NM_004473.4), FSCN2 (Gene bank accession number: NM_012418.4), FTMT (Gene bank accession number: NM_177478.2), PI4KB (Gene bank accession number: NM_002651.4), GLYCTK (Gene bank accession number: NM_145262.4), GLYR1 (Gene bank accession number: NM_032569.4), INTU (Gene bank accession number: NM_015693). 4), POGLUT2 (Gene bank accession number: NM_001318732.2), KDM4B (Gene bank accession number: NM_015015.3), KIAA0355 (Gene bank accession number: NM_014686.4), KIRREL2 (Gene bank accession number: NM_199180.4) , KLKB1 (Gene bank accession number: NM_000892.5), KRT37 (Gene bank accession number: NM_003770.5), LETMD1 (Gene bank accession number: NM_015416.5), MAML2 (Gene bank accession number: NM_032427.4), MAP1B (Gene bank accession number: NM_005909.5) and METTL9 (Gene bank accession number: NM_016025.5).

The full names of the abbreviations of the genes are ASPH (aspartate beta-hydroxylase), ITPR1 (inositol 1,4,5-trisphosphate receptor type 1), SHISAL1 (shisa like 1), ABCC10 (ATP binding cassette subfamily C member 10), respectively, ACTL6A (actin like 6A), ADARB2 (adenosine deaminase RNA specific B2 (inactive), ANKRD30B (ankyrin repeat domain 30B), ARHGAP10 (Rho GTPase activating protein 10), ATRNL1 (attractin like 1), C11orf24 (chromosome 11 open reading frame 24) ), CAMKK1 (calcium/calmodulin dependent protein kinase kinase 1), CD14 (CD14 molecule), CELF3 (CUGBP Elav-like family member 3), CLCN2 (chloride voltage-gated channel 2), CLIP4 (CAP-Gly domain containing linker protein) family member 4), CRIM1 (cysteine rich transmembrane BMP regulator 1), CXorf56 (chromosome X open reading frame 56), CYP4F11 (cytochrome P450 family 4 subfamily F member 11), DYTN (dystrotelin), FIGNL1 (fidgetin like 1), FOXE1 (forkhead box E1), FSCN2 (fascin actin-bundling protein 2, retinal), FTMT (ferritin mitochondrial), PI4KB (phosphatidylinositol 4-k) inase beta), GLYCTK (glycerate kinase), GLYR1 (glyoxylate reductase 1 homolog), INTU (inturned planar cell polarity protein), POGLUT2 (protein O-glucosyltransferase 2), KDM4B (lysine demethylase 4B), KIAA0355 (granule associated Rac and RHOG) effector 1), KIRREL2 (kirre like nephrin family adhesion molecule 2), KLKB1 (kallikrein B1), KRT37 (keratin 37), LETMD1 (LETM1 domain containing 1), MAML2 (mastermind like transcriptional coactivator 2), MAP1B (microtubule associated protein 1B) ) and METTL9 (methyltransferase like 9).

In another embodiment of the present invention, the agent may be a composition for predicting treatment effect or prognosis diagnosis according to the age of a prostate cancer patient, which includes a primer set, a probe, or an antibody for the mutation of the gene.

In the present invention, the term 'diagnosis' refers to confirming the presence or characteristics of a pathological state, and for the purpose of the present invention, not only confirming the difference in the cancer treatment effect depending on whether the cancer patient has metastasized, but also confirming the difference in the cancer treatment effect after the cancer treatment. means to judge whether recurrence, drug reactivity, resistance, etc. Preferably, when using the mutation of the gene of the present invention, by confirming whether the mutation is in the sample of the prostate cancer patient, the difference in the prostate cancer treatment effect according to the age of the prostate cancer patient and the difference in the survival rate that can determine the prognosis of the patient in the future It is also predictable.

In the present invention, the term 'prognosis' refers to the progress and cure of neoplastic diseases such as cancer, such as the possibility of cancer-caused death or progression, including recurrence, metastatic spread, and drug resistance, for example. For the purpose of the present invention, it may be to predict the prognosis of prostate cancer, preferably to predict the disease-free or survival rate of prostate cancer patients.

As used herein, the term 'cancer' includes any member of a class of diseases characterized by the uncontrolled growth of abnormal cells. The term includes all known cancers and neoplastic conditions, whether characterized as malignant, benign, soft tissue or solid, and cancers of all stages and grades, including cancers before and after metastasis.

In the present invention, the term 'gene' and its variants include a DNA fragment involved in the generation of a polypeptide chain; It includes regions before and after the coding region, eg promoters and 3'-untranslated regions, respectively, as well as intervening sequences (introns) between individual coding fragments (exons).

The mutation of the gene may include any one or more mutations, for example, a truncating mutation, a missense mutation (or a missense mutation), a nonsense mutation, a frame shift ) mutation, in-frame mutation (or in-frame mutation), splice mutation, and splice_region mutation may have at least one mutation selected from the group consisting of. The frame shift mutation may be at least one of a frame shift insert (FS ins) mutation and a frame shift delete mutation (FS del). The in-frame mutation may be at least one of an in-frame insertion (IF ins) mutation and an in-frame delete (IF del) mutation.

In the present invention, the term 'missense mutation' refers to a mutation in which one base in a DNA base sequence is substituted with another base to change the codon of an amino acid to another codon.

In the present invention, the term 'nonsense mutation' refers to a mutation in which a part of a specific nucleotide sequence of a gene is converted to a stop codon so that protein synthesis is no longer made.

In the present invention, the term 'frame shift insertion' refers to a mutation that occurs when one or more nucleotides are added to DNA to shift the decoding frame of the genetic code.

In the present invention, the term 'frame shift deletion' refers to a mutation in which one or more nucleotides are deleted in DNA and the reading frame of the genetic code is shifted and shifted.

In the present invention, the term 'in-frame deletion' refers to a mutation in which a specific nucleotide sequence of a gene is deleted, but there is no change in the other amino acids except for the amino acid due to the deleted nucleotide sequence.

As used herein, the term 'splice mutation' refers to a gene mutation in which a nucleotide at a specific position of a gene is substituted.

The term “X#Y” with respect to mutations in a polypeptide sequence is self-recognized in the art, where “#” denotes the mutation site with respect to the amino acid number of the polypeptide, and “X” denotes that of the wild-type amino acid sequence. indicates the amino acid found at that position, and "Y" indicates the mutant amino acid at that position. For example, the designation "G1717V" with respect to a BAZ2B polypeptide indicates that glycine is present at amino acid number 1717 of the wild-type BAZ2B sequence and that glycine has been replaced by valine in the mutant BAZ2B sequence.

The term “*” in reference to mutations in polypeptide sequences is readily recognized in the art where “*” may be used to indicate translation stop codons in the one and three amino acid codes, e.g., nonsense mutations In *, indicates that the amino acid synthesis at the corresponding amino acid position is terminated.

The term "_" with respect to a mutation in a polypeptide sequence is clearly recognized in the art, where "_" indicates a range and, for example, when A200_C240 is used, the alanine of the 200 amino acid sequence of the polypeptide. ) to cysteine located in the amino acid sequence at number 240 indicates the range.

The term “del” with respect to a mutation in a polypeptide sequence is self-recognized in the art, where “del” denotes a deletion, for example, when used as V7del, the 7th position of a specific sequence is valine. , and when used as V76_S79del, it means a mutation in which a deletion from valine located at position 76 to serine located at position 79 in a specific sequence has occurred.

The term “ins” in reference to a mutation in a polypeptide sequence is art-recognized as is self-evident in the art where “ins” denotes an insertion, e.g., when used as V76_S77insV, from valine 76 to 77 in a particular sequence. It refers to a mutation in which valine is inserted between the serine located at the bun.

The term “fs” in reference to a mutation in a polypeptide sequence is readily recognized in the art where “fs” stands for a frame shift, e.g., the 97th position in a particular sequence when used as V97SfsTer23 or V97Sfs*23 It indicates that the located valine is changed to serine and there is a termination codon (Termination, Ter) at the position 23 (120th amino acid sequence) after it, and when V76_S79*? , means a mutation in which a new stop codon does not appear.

Next generation sequencing (NGS), RT-PCR, direct nucleic acid sequencing method, and microarray can be used as an analysis method for diagnosing the prognosis of prostate cancer using the mutation of the gene. Any method that can confirm the existence of a mutation using a mutation of a gene can be applied without limitation.

In one embodiment, the presence of a mutation is determined using an anti-(mutant of each gene) antibody or nucleic acid probe that hybridizes under stringent conditions to the polynucleotide of the mutant of each gene.

In another embodiment, the antibody or nucleic acid probe is detectably labeled. In another embodiment, the label is selected from the group consisting of an immunofluorescent label, a chemiluminescent label, a phosphorescent label, an enzymatic label, a radioactive label, avidin/biotin, colloidal gold particles, colored particles, and magnetic particles.

In another embodiment, the presence of the mutation is determined by radioimmunoassay, western blot assay, immunofluorescence assay, enzymeimmunoassay, immunoprecipitation assay, chemiluminescence assay, immunohistochemical assay, dot blot assay, slot blot assay, or flow cytometry. determined by the assay.

In another embodiment, the presence of the mutation is determined by RT-PCR. In another embodiment, the presence of the mutation is determined by nucleic acid sequencing.

As used herein, the term 'polynucleotide' generally refers to any polyribonucleotide or polydeoxyribonucleotide, which may be unmodified RNA or DNA or modified RNA or DNA. Thus, for example, polynucleotides as defined herein include, but are not limited to, single- and double-stranded DNA, DNA comprising single- and double-stranded regions, single- and double-stranded RNA, and single- and double-stranded DNA. - RNA comprising a single-stranded region, or a hybrid comprising DNA and RNA, which may be single-stranded or more typically double-stranded or may comprise single- and double-stranded regions

contains molecules. Thus, DNA or RNA having a backbone that has been modified for stability or other reasons is a 'polynucleotide' as the term is intended herein. Also included in the term 'polynucleotide' as defined herein is DNA or RNA comprising an unconventional base such as inosine or a modified base such as a tritiated base. In general, the term 'polynucleotide' includes all chemically, enzymatically and/or metabolically modified forms of unmodified polynucleotides. Polynucleotides can be prepared by a variety of methods, including in vitro recombinant DNA-mediated techniques, and by expression of DNA in cells and organisms.

Another aspect of the present invention is to provide a kit for predicting treatment effect or prognosis diagnosis according to the age of a prostate cancer patient, comprising the composition.

The kit of the present invention prepared as described above is very economical because it saves time and money compared to the existing general gene mutation search method. Using existing gene mutation detection methods such as Single Strand Conformational Polymorphism (SSCP), Protein Truncation Test (PTT), cloning, and direct sequencing, it takes several days on average to test all one gene. It takes several months. In addition, gene mutations can be precisely tested quickly and simply through next generation sequencing (NGS). In the case of testing mutations by existing analysis methods such as SSCP, cloning, direct sequencing, and RFLP (Restriction Fragment Length Polymorphism), it takes about a month to complete the test, whereas using the kit of the present invention, the sample DNA is prepared If it is done, results can be obtained within about 10 to 11 hours, and since a primer set capable of detecting mutations is integrated on one chip, not only time but also cost can be reduced compared to the conventional method. Compared to the conventional method, the average cost of reagents is less than half per experiment, so even greater cost savings can be expected when considering the researcher's labor costs.

2. Method of providing information necessary for prognostic diagnosis of prostate cancer using survival-specific mutant gene

Another aspect of the present invention comprises the steps of preparing a sample DNA from a sample of a prostate cancer patient of known age; amplifying the sample DNA using the kit; determining the presence or absence of an age-specific marker from the amplification result; Treating a prostate cancer patient whose age-specific markers have been identified with any prostate cancer treatment candidate or by any method; And any prostate cancer treatment candidate material or any treatment method improves prostate cancer or, when treated, adopting it as a treatment candidate material or treatment method suitable for prostate cancer patients whose age-specific markers have been identified; prostate cancer comprising; Provided is a method for providing information necessary to determine the difference in cancer treatment effect according to the age of a patient.

Any of the therapeutic candidate substances may be a therapeutic agent commonly used for the treatment of prostate cancer or a novel substance whose therapeutic effect on prostate cancer is unknown, but is not limited thereto. Whether the treatment candidate material is effective in a specific patient group can be determined by checking the therapeutic effect after treating any of the above treatment candidate substances on a prostate cancer patient having an age-specific marker. If there is a treatment effect for prostate cancer, the treatment effect can be predicted to be high when applied to a patient group having the same age-specific marker, so it can provide useful information for determining a treatment strategy. In addition, if a therapeutic effect does not appear when using any treatment candidate, treatment strategy can be efficiently designed because unnecessary treatment is not required by not proceeding with treatment for the patient group having the same age-specific marker. have.

Any prostate cancer treatment method is also applicable instead of any of the above treatment candidates, and it is possible to determine whether to apply to a patient group having the same age-specific marker by confirming the therapeutic effect in a patient group having a specific age-specific marker. When confirming the therapeutic effect in a patient group having an age-specific marker, any treatment candidate substance and any prostate cancer treatment method may be combined.

In one embodiment of the present invention, the age-specific markers include ASPH, ITPR1, SHISAL1, ABCC10, ACTL6A, ADARB2, ANKRD30B, ARHGAP10, ATRNL1, C11orf24, CAMKK1, CD14, CELF3, CLCN2, CLIP4, CRIM1, CXorf56, CYP4F56 mutations selected from the group consisting of genes encoding DYTN, FIGNL1, FOXE1, FSCN2, FTMT, PI4KB, GLYCTK, GLYR1, INTU, POGLUT2, KDM4B, KIAA0355, KIRREL2, KLKB1, KRT37, LETMD1, MAML2, MAP1B and METTL9. It can be a method that is

Another aspect of the present invention comprises the steps of preparing a sample DNA from a sample of a prostate cancer patient; amplifying the sample DNA using the kit; and confirming the presence or absence of an age-specific marker from the amplification result; provides a method for providing information necessary for prognostic diagnosis of prostate cancer according to the age of a patient with prostate cancer, including.

For the description of the kit for prognostic diagnosis of prostate cancer, see '1. Since it is the same as described in 'Age-specific mutated gene in prostate cancer patients', a detailed description will be omitted.

As used herein, the term 'sample' includes any biological sample obtained from a patient. Samples include whole blood, plasma, serum, red blood cells, white blood cells (eg peripheral blood mononuclear cells), ductal fluid, ascites, pleural efflux, nipple aspirate, lymphatic fluid (eg disseminated tumors of lymph nodes) cells), bone marrow aspirate, saliva, urine, feces (ie feces), sputum, bronchial lavage fluid, tears, fine needle aspirate (eg harvested by random mammary fine needle aspiration), any other bodily fluid, tissue A sample (eg tumor tissue) such as a tumor biopsy (eg puncture biopsy) or lymph node (eg sentinel lymph node biopsy), a tissue sample (eg tumor tissue), eg surgical resection of a tumor and cell extracts thereof. In some embodiments, the sample is whole blood or some component thereof, such as plasma, serum or cell pellet. In another embodiment, the sample is obtained by isolating circulating cells of a solid tumor from whole blood or a cell fraction thereof using any technique known in the art. In another embodiment, the sample is a formalin fixed paraffin embedded (FFPE) tumor tissue sample from a solid tumor, eg, colorectal cancer.

In certain embodiments, the sample is a tumor lysate or extract prepared from frozen tissue obtained from a subject with colorectal cancer.

The term 'patient' usually includes humans as well as other animals, such as other primates, rodents, dogs, cats, horses, sheep, pigs, and the like.

The term 'subject' includes subjects other than humans diagnosed with or suspected of having prostate cancer.

The method can predict the overall survival or disease-free survival of patients with prostate cancer.

In the present invention, the term 'overall survival' includes a clinical endpoint describing a patient who is alive for a limited time after being diagnosed with or treated for a disease, such as cancer, and the survival rate with or without cancer recurrence. means possibility.

In the present invention, the term 'disease-free survival (DFS)' includes the period in which a patient survives without cancer recurrence after treatment for a specific disease (eg, cancer).

In the present invention, by analyzing the presence of a mutation in a gene of the present invention in a sample of a prostate cancer patient, it is possible to determine what prognosis an individual having the target sample has for cancer. Also, this method can be achieved by comparing the total survival or disease-free survival of subjects in a control group that does not have a mutation known to have a good prognosis. In the present invention, an individual known to have a good prognosis means an individual who has no history of metastasis, recurrence, death, etc. after the onset of cancer.

The sample of an individual suspected of cancer refers to a sample of an individual or tissue in which cancer or tumor has already occurred or is expected to occur, and is a target sample for diagnosing the prognosis.

The method of providing information necessary for prognostic diagnosis of prostate cancer according to the age of the prostate cancer patient can predict the total survival rate or disease-free survival rate of the prostate cancer patient. For example, in the method, a mutation is identified in the genes encoding ASPH, ITPR1 and SHISAL1, and when a patient with prostate cancer, the survival rate of the prostate cancer patient is lower than that of a person whose mutation is not identified in the gene, or determining that the recurrence rate of prostate cancer in the prostate cancer patient is higher than the recurrence rate of prostate cancer in a person whose mutation is not identified in the gene; may further include.

The method of providing information necessary for prognostic diagnosis of prostate cancer according to the age of the prostate cancer patient is ABCC10, ACTL6A, ADARB2, ANKRD30B, ARHGAP10, ATRNL1, C11orf24, CAMKK1, CD14, CELF3, CLCN2, CLIP4, CRIM1, CXorf56, METTL encoding at least one selected from the group consisting of CYP4F11, DYTN, FIGNL1, FOXE1, FSCN2, FTMT, PI4KB, GLYCTK, GLYR1, INTU, POGLUT2, KDM4B, KIAA0355, KIRREL2, KLKB1, KRT37, LETMD1, MAML2, MAP1B and METTL. When a mutation is identified in a gene, the survival rate of a patient with prostate cancer is lower than that of a person whose mutation is not identified in the gene, or the recurrence rate of prostate cancer in the prostate cancer patient is the prostate of a person whose mutation is not identified in the gene It may further include; determining that the cancer recurrence rate is higher than that.

As such, the mutants of the genes of the present invention, ASPH, ITPR1, SHISAL1, ABCC10, ACTL6A, ADARB2, ANKRD30B, ARHGAP10, ATRNL1, C11orf24, CAMKK1, CD14, CELF3, CLCN2, CLINLP4, CRIM1, CXorf56, CYP4F11, Using a mutation of at least one cancer gene selected from the group consisting of FOXE1, FSCN2, FTMT, PI4KB, GLYCTK, GLYR1, INTU, POGLUT2, KDM4B, KIAA0355, KIRREL2, KLKB1, KRT37, LETMD1, MAML2, MAP1B and METTL However, it has not yet been revealed that there is a difference in genetic mutations according to the age of onset of prostate cancer. In addition, ASPH, ITPR1, SHISAL1, ABCC10, ACTL6A, ADARB2, ANKRD30B, ARHGAP10, ATRNL1, C11orf24, CAMKK1, CD14, CELF3, CLCN2, CLIP4, CRIM1, CXorf56, CYP4F11, FTTN, FIG1NL KBOX Prognosis for prostate cancer at a specific age using a mutation in at least one gene selected from the gene group consisting of GLYCTK, GLYR1, INTU, POGLUT2, KDM4B, KIAA0355, KIRREL2, KLKB1, KRT37, LETMD1, MAML2, MAP1B and METTL As yet, nothing has been revealed as to what can be diagnosed. Also, it has not been reported that the total survival rate or disease-free survival rate may be different for each gene. The present inventors have identified for the first time that mutations in the above genes can be used as diagnostic markers for predicting the difference in the treatment effect of prostate cancer according to the age of the prostate cancer patient or diagnosing the prognosis of the prostate cancer patient.

The method for providing information necessary for predicting the difference in the treatment effect of prostate cancer according to the age of the prostate cancer patient of the present invention is to diagnose the genetic mutation of the prostate cancer based on the age, increase the survival rate of the prostate cancer patient, or It can be used to lower the recurrence rate. Through the method for prognostic diagnosis of prostate cancer of the present invention, it is possible to predict the therapeutic effect of prostate cancer, or the survival or recurrence rate of prostate cancer patients, using information on the generation of mutations in genes according to the age of prostate cancer, so that each patient It can provide information on the selection of treatments as well as the discovery of suitable therapeutics for the treatment of prostate cancer, enabling efficient design of therapeutic strategies for prostate cancer.

Hereinafter, the present invention will be described in detail by way of Examples and Experimental Examples.

However, the following Examples and Experimental Examples are only for illustrating the present invention, and the content of the present invention is not limited by the following Examples and Experimental Examples.

[Example]

Example 1. Securing genetic information and clinical information

Genes of the present invention (ASPH, ITPR1, SHISAL1, ABCC10, ACTL6A, ADARB2, ANKRD30B, ARHGAP10, ATRNL1, C11orf24, CAMKK1, CD14, CELF3, CLCN2, CLIP4, CRIM1, CXorf56, CYP4FNL1, FOXE1, CYP4FNL1, DYTN FTMT, PI4KB, GLYCTK, GLYR1, INTU, POGLUT2, KDM4B, KIAA0355, KIRREL2, KLKB1, KRT37, LETMD1, MAML2, MAP1B and METTL (hereinafter also referred to as ‘candidate genes’) can be used as age-dependent prostate cancer markers In order to confirm whether or not there is, data on recurrence, metastasis, death, and observation time of 498 patients with transparent prostate cancer who have both genetic and clinical information from The Cancer Genome Atlas (TCGA) were obtained and used for analysis. Table 1 below shows data on recurrence, metastasis, and death of prostate cancer patients. The above candidate genes are genes that have been mutated in prostate cancer patients according to age.

Sum Number of patients (persons) ratio (%) survival or not survival 488/498 98% Dead 10/498 2% relapse disease free 401/488 82.2% recurrence/progression 87/488 17.8% transition None (M0) 456/459 99.4% Yes (M1) 3/459 0.6% total number of patients 498 people

Example 2. Confirmation of utility as an age-specific marker

498 patients with prostate cancer reported by TCGA were classified into 4 groups as shown in Table 2, and the correlation between mutations and age of the candidate genes of Example 1 was analyzed by three Feature Selection (Information Gain, Chi-Square, MRMR) methods. was confirmed as The classification of the four groups is shown in the table below.

age group age Number of patients (%) I ≤50 35 (7.0%) II 51 to 60 189 (38.0%) Ⅲ 61-70 237 (47.6%) IV ≥71 37 (7.4%)

2-1. Comparative analysis between each group (age group Ⅰvs Ⅱ vs Ⅲ vs Ⅳ)

For each of the four age groups divided by group in Table 2, the association between the occurrence of mutations in candidate genes and the age of the prostate cancer patient was confirmed. A P-value of less than 0.05 was considered statistically significant. Information on candidate genes involved in comparative analysis between each group is shown in Tables 3 to 5 below.

gene age group mutation
Number Mutation (%) Mutation type Saito
band Age group (%) Fisher (p-value) I II ² ₃ cut missense in-frame Etc I ± ² ₃ ABCC10 0 0 0 3 3 0.6 One 2 0 0 6p21.1 0 0 0 100 0.0007 ABCC8 0 0 0 4 4 0.8 One 3 0 0 11p15.1 0 0 0 100 4.68E-05 ACTL6A 0 0 0 2 2 0.4 0 2 0 0 3q26.33 0 0 0 100 0.01019 ADAM11 2 0 0 0 2 0.4 0 2 0 0 17q21.31 100 0 0 0 0.004808 ADARB2 0 0 0 3 3 0.6 0 3 0 0 10p15.3 0 0 0 100 0.0007 AGBL1 0 0 0 3 3 0.6 0 3 0 0 15q25.3 0 0 0 100 0.0007 ALKBH1 0 0 0 2 2 0.4 0 2 0 0 14q24.3 0 0 0 100 0.01019 AMPD2 0 0 0 4 4 0.8 0 4 0 0 1p13.3 0 0 0 100 4.68E-05 ANKRD30B 0 0 0 3 3 0.6 0 3 0 0 18p11.21 0 0 0 100 0.0007 APLP2 0 0 0 2 2 0.4 0 2 0 0 11q24.3 0 0 0 100 0.01019 APOO 0 0 0 2 2 0.4 0 2 0 0 Xp22.11 0 0 0 100 0.01019 ARHGAP10 0 0 0 2 2 0.4 One One 0 0 4q31.23 0 0 0 100 0.01019 ARID3B 0 0 0 2 2 0.4 0 2 0 0 15q24.1 0 0 0 100 0.01019 ASPH 0 0 0 2 2 0.4 0 2 0 0 8q12.3 0 0 0 100 0.01019 ATNL1 0 0 0 2 2 0.4 0 2 0 0 10q25.3 0 0 0 100 0.01019 B3GALT5 0 0 0 3 3 0.6 0 3 0 0 21q22.2 0 0 0 100 0.0007 B4GALT6 0 0 0 3 3 0.6 One 2 0 0 18q12.1 0 0 0 100 0.0007 BCR 0 0 0 2 2 0.4 0 2 0 0 22q11.23 0 0 0 100 0.01019 BIRC5 One 0 0 0 One 0.2 0 One 0 0 17q25.3 100 0 0 0 0.07028 BRD1 0 One 2 2 5 1.0 0 5 0 0 22q13.33 0 20 40 40 0.1274

gene age group mutation
Number Mutation (%) Mutation type Saito
band Age group (%) Fisher (p-value) I II ² ₃ cut missense in-frame Etc I ± ² ₃ BTN2A2 0 0 0 2 2 0.4 0 2 0 0 6p22.2 0.0 0.0 0.0 100.0 0.01019 C10orf12 0 0 0 2 2 0.4 0 2 0 0 10q24.1 0.0 0.0 0.0 100.0 0.01019 C11orf24 0 0 0 2 2 0.4 0 2 0 0 11q13.2 0.0 0.0 0.0 100.0 0.01019 C20orf194 0 One 0 3 4 0.8 0 4 0 0 20p13 0.0 25.0 0.0 75.0 0.001475 C7orf57 0 0 0 2 2 0.4 One One 0 0 7p12.3 0.0 0.0 0.0 100.0 0.01019 CABP1 0 0 0 One One 0.2 0 One 0 0 12q24.31 0.0 0.0 0.0 100.0 0.1446 CAMKK1 0 0 0 2 2 0.4 0 2 0 0 17p13.2 0.0 0.0 0.0 100.0 0.01019 CD14 0 0 0 2 2 0.4 0 2 0 0 5q31.3 0.0 0.0 0.0 100.0 0.01019 CELF3 0 0 0 2 2 0.4 One One 0 0 1q21.3 0.0 0.0 0.0 100.0 0.01019 CERCAM 0 0 One 2 3 0.6 0 3 0 0 9q34.11 0.0 0.0 33.3 66.7 0.02917 CHRNA6 0 0 One 5 6 1.2 3 3 0 0 8p11.21 0.0 0.0 16.7 83.3 2.34E-05 CLCN2 0 0 0 2 2 0.4 0 2 0 0 3q27.1 0.0 0.0 0.0 100.0 0.01019 CLIP4 0 0 0 2 2 0.4 0 2 0 0 2p23.2 0.0 0.0 0.0 100.0 0.01019 CLSTN1 0 0 0 3 3 0.6 One 2 0 0 1p36.22 0.0 0.0 0.0 100.0 0.0007 CRHR2 0 0 0 2 2 0.4 0 2 0 0 7p14.3 0.0 0.0 0.0 100.0 0.01019 CRIM1 0 0 0 2 2 0.4 0 2 0 0 2p22.2 0.0 0.0 0.0 100.0 0.01019 CRYBG3 0 0 0 2 2 0.4 0 2 0 0 3q11.2 0.0 0.0 0.0 100.0 0.01019 CRYGN 0 0 0 2 2 0.4 0 2 0 0 7q36.1 0.0 0.0 0.0 100.0 0.01019 CXorf56 0 0 0 2 2 0.4 0 2 0 0 Xq24 0.0 0.0 0.0 100.0 0.01019 CYP2A6 0 One 0 2 3 0.6 One 2 0 0 19q13.2 0.0 33.3 0.0 66.7 0.01456

gene age group mutation
Number suddenness
transition
(%) Mutation type Saito
band Age group (%) Fisher (p-value) I II ² ₃ cut missense in-frame Etc I ± ² ₃ CYP4F11 0 0 0 2 2 0.4 0 2 0 0 19p13.12 0.0 0.0 0.0 100.0 0.01019 DCAF15 0 0 0 2 2 0.4 0 2 0 0 19p13.12 0.0 0.0 0.0 100.0 0.01019 DET1 0 0 0 2 2 0.4 0 2 0 0 15q26.1 0.0 0.0 0.0 100.0 0.01019 DHX16 0 0 0 2 2 0.4 0 2 0 0 6p21.33 0.0 0.0 0.0 100.0 0.01019 DNA2 0 0 0 3 3 0.6 One 2 0 0 10q21.3 0.0 0.0 0.0 100.0 0.0007 DNAH6 0 0 0 2 2 0.4 0 2 0 0 2p11.2 0.0 0.0 0.0 100.0 0.01019 DOCK11 0 One 0 3 4 0.8 2 2 0 0 Xq24 0.0 25.0 0.0 75.0 0.001475 DPY19L2 One 0 2 5 8 1.6 0 8 0 0 12q14.2 12.5 0.0 25.0 62.5 2.94E-05 DYRK4 0 0 0 2 2 0.4 0 2 0 0 12p13.32 0.0 0.0 0.0 100.0 0.01019 DYTN 0 0 0 2 2 0.4 One One 0 0 2q33.3 0.0 0.0 0.0 100.0 0.01019 DZIP3 0 0 0 2 2 0.4 One One 0 0 3q13.13 0.0 0.0 0.0 100.0 0.01019 EMC1 0 0 0 2 2 0.4 0 2 0 0 1p36.13 0.0 0.0 0.0 100.0 0.01019 ENGASE 0 0 0 2 2 0.4 One 0 One 0 17q25.3 0.0 0.0 0.0 100.0 0.01019 EPHA2 0 0 0 2 2 0.4 0 2 0 0 1p36.13 0.0 0.0 0.0 100.0 0.01019 ERC2 0 2 0 2 4 0.8 0 2 2 0 3p14.3 0.0 50.0 0.0 50.0 0.01929 ERI2 0 0 0 2 2 0.4 0 2 0 0 16p12.3 0.0 0.0 0.0 100.0 0.01019 ETNPPL 2 0 One 0 3 0.6 0 3 0 0 4q25 66.7 0.0 33.3 0.0 0.02146 FDXR 0 0 0 2 2 0.4 0 2 0 0 17q25.1 0.0 0.0 0.0 100.0 0.01019 FIGNL1 0 0 0 2 2 0.4 2 0 0 0 7p12.2 0.0 0.0 0.0 100.0 0.01019 FOXE1 2 0 0 0 2 0.4 0 0 2 0 9q22.33 100.0 0.0 0.0 0.0 0.004808

gene age group mutation
Number Mutation (%) Mutation type Saito
band Age group (%) Fisher (p-value) I II ² ₃ cut missense in-frame Etc I ± ² ₃ FOXP4 0 0 0 2 2 0.4 One One 0 0 6p21.1 0.0 0.0 0.0 100.0 0.01019 FRMD6 0 0 0 2 2 0.4 0 2 0 0 14q22.1 0.0 0.0 0.0 100.0 0.01019 FSCN2 0 0 0 2 2 0.4 0 2 0 0 17q25.3 0.0 0.0 0.0 100.0 0.01019 FTMT 0 0 0 2 2 0.4 0 2 0 0 5q23.1 0.0 0.0 0.0 100.0 0.01019 GOLGA3 2 0 0 0 2 0.4 One One 0 0 12q24.33 100.0 0.0 0.0 0.0 0.004808 GRK6 0 0 0 3 3 0.6 0 2 One 0 5q35.3 0.0 0.0 0.0 100.0 0.0007 HELB 0 3 0 5 8 1.6 0 8 0 0 12q14.3|12q 0.0 37.5 0.0 62.5 3.48E-05 ITPR1 0 0 0 4 4 0.8 One 3 0 0 3p26.1 0.0 0.0 0.0 100.0 4.68E-05 MCM3AP 0 0 One 5 6 1.2 One 5 0 0 21q22.3 0.0 0.0 16.7 83.3 2.34E-05 MPDZ 0 0 0 3 3 0.6 0 3 0 0 9p23 0.0 0.0 0.0 100.0 0.0007 MYRIP 0 0 0 3 3 0.6 0 3 0 0 3p22.1 0.0 0.0 0.0 100.0 0.0007 NDST2 0 One 0 4 5 1.0 One 4 0 0 10q22.2 0.0 20.0 0.0 80.0 0.000195 NR3C2 0 0 0 3 3 0.6 0 3 0 0 4q31.23 0.0 0.0 0.0 100.0 0.0007 OR52N5 2 0 0 0 2 0.4 2 0 0 0 11p15.4 100.0 0.0 0.0 0.0 0.004808 OR5B12 0 0 0 3 3 0.6 0 3 0 0 11q12.1 0.0 0.0 0.0 100.0 0.0007 PI4KB 2 0 0 0 2 0.4 0 2 0 0 1q21.3 100.0 0.0 0.0 0.0 0.004808 PPP1R3B 2 0 0 0 2 0.4 0 2 0 0 8p23.1 100.0 0.0 0.0 0.0 0.004808 SBNO2 2 0 0 0 2 0.4 2 0 0 0 19p13.3 100.0 0.0 0.0 0.0 0.004808 SPTBN2 0 2 One 3 6 1.2 0 6 0 0 11q13.2 0.0 33.3 16.7 50.0 0.01399 TAS1R2 0 0 One 3 4 0.8 0 4 0 0 1p36.13 0.0 0.0 25.0 75.0 0.002815 ZMYM4 0 0 0 3 3 0.6 One 2 0 0 1p34.3 0.0 0.0 0.0 100.0 0.0007

As a result of the analysis, in each age group, even if the gene had a mutation, there were genes with a P-value of 0.05 or more when compared with other groups, while genes with a mutation and a P-value of less than 0.05 were identified. Mutant genes with a P-value of less than 0.05 compared to other groups were identified as age-specific genes because they were correlated with a specific age group compared to other groups. shows the results. As can be seen in Figure 1, ABCC10, ABCC8, ACTL6A, ADARB2, AGBL1, ALKBH1, AMPD2, ANKRD30B, APLP2, APOO, ARHGAP10, ARID3B, ASPH, ATRNL1, B3GALTS, B4GALT6, BCR, C20orf57, C11orf12, C11orf12, C11orf CAMKK1, CD14, CELF3, CERCAM, CHRNA6, CLCN2, CLIP4, CLSTN1, CRHR2, CRIM1, CRYBG3, CRYGN, Cxorf56, CYP2A6, CYP4F11, DCAF15, DET1, DHX16, DNA2, DNAH6, DOCKL DY, DRK4, DNAH6, DOCK EMC1, ENGASE, EPHA2, ERC2, ERI2, FDXR, FIGNL1, FOXP4, FRMD6, FSCN2, FTMT, GRK6, HELB, ITPR1, MCM3AP, MPDZ, MYRIP, NDST2, NR3C2, OR5B12, SPTBN2, TAS1R It was confirmed that a lot of mutations appeared in the group, ADAM11, FOXE1, GOLGA3, OR52N5, PI4KB, PPP1R3B and SBNO2 were found to have a lot of mutations in group I, and it was confirmed that ETNPPL showed a lot of mutations in group Ⅲ.

From the above results, ABCC10, ABCC8, ACTL6A, ADARB2, AGBL1, ALKBH1, AMPD2, ANKRD30B, APLP2, APOO, ARHGAP10, ARID3B, ASPH, ATRNL1, B3GALTS, B4Gorf6, BCR, BTN57194, CAM7C10orf24, C20Korf24, CCAM7C10orf12, CD14, CELF3, CERCAM, CHRNA6, CLCN2, CLIP4, CLSTN1, CRHR2, CRIM1, CRYBG3, CRYGN, Cxorf56, CYP2A6, CYP4F11, DCAF15, DET1, DHX16, TN DNA2, DNAH6, DOLCK11, DY4, EMC, DOLCK2, DY4 ENGASE, EPHA2, ERC2, ERI2, FDXR, FIGNL1, FOXP4, FRMD6, FSCN2, FTMT, GRK6, HELB, ITPR1, MCM3AP, MPDZ, MYRIP, NDST2, NR3C2, OR5B12, SPTBN2, TAS1GAR3, ZMYMO OR5B12, SPTBN2, TAS4OL3, ZMYE1 It can be seen that 78 mutations of OR52N5, PI4KB, PPP1R3B, SBNO2 and ETNPPL can be used as specific markers for groups I, III or IV.

2-2. Comparative analysis of group Ⅰ and other groups (age group Ⅰ vs Ⅱ + Ⅲ + Ⅳ)

In Table 2, among the four age groups divided by group, for the lowest age (I) and the remaining ages (II, III, and IV), the association between the occurrence of mutations in candidate genes and the age of prostate cancer patients was confirmed. A P-value of less than 0.05 was considered statistically significant. Information on candidate genes related to Tables 7 to 10 is shown below.

gene mutation
Number mutation
(%) Saito
band Mutation type Age Fisher's exact
(P-Value) cut miss
sense in-frame Etc I II+III+IV II+III+IV
(%) ACBD7 One 0.2 10p13 0 One 0 0 One 0 0.0 0.072 ADAM11 2 0.4 17q21.31 0 2 0 0 2 0 0.0 0.005 ADCY1 3 0.7 7p12.3 One 2 0 0 One 2 66.7 0.201 AGK 2 0.4 7q34 One One 0 0 2 0 0.0 0.005 AKR1D1 One 0.2 7q33 0 One 0 0 One 0 0.0 0.072 ALPI One 0.2 2q37.1 0 One 0 0 One 0 0.0 0.072 AMMECR1 One 0.2 Xq23 0 0 One 0 One 0 0.0 0.072 ANKRD40 One 0.2 17q21.33 0 One 0 0 One 0 0.0 0.072 ANXA6 2 0.4 5q33.1 0 2 0 0 One One 50.0 0.139 APPL1 One 0.2 3p14.3 0 One 0 0 One 0 0.0 0.072 AQP12A One 0.2 2q37.3 0 One 0 0 One 0 0.0 0.072 ARHGAP15 One 0.2 2q22.2-q22.3 One 0 0 0 One 0 0.0 0.072 ARHGEF18 One 0.2 19p13.2 0 One 0 0 One 0 0.0 0.072 ASIC5 One 0.2 4q32.1 0 One 0 0 One 0 0.0 0.072 ATG4D One 0.2 19p13.2 0 One 0 0 One 0 0.0 0.072 ATP6V1E2 One 0.2 2p21|2p16-p12 0 One 0 0 One 0 0.0 0.072 BIRC2 One 0.2 11q22.2 0 One 0 0 One 0 0.0 0.072 BIRC5 One 0.2 17q25.3 0 One 0 0 One 0 0.0 0.072 BMI1 One 0.2 10p12.2 One 0 0 0 One 0 0.0 0.072 C10orf10 One 0.2 10q11.21 0 One 0 0 One 0 0.0 0.072

gene mutation
Number mutation
(%) Saito
band Mutation type age Fisher's exact (P-Value) cut missense in-frame Etc I II+III+IV II+III+IV
(%) C15orf59 One 0.2 15q24.1 0 One 0 0 One 0 0.0 0.072 C1QTNF8 One 0.2 16p13.3 One 0 0 0 One 0 0.0 0.072 C2orf78 One 0.2 2p13.1 0 One 0 0 One 0 0.0 0.072 CA10 One 0.2 17q21.33-q22 0 One 0 0 One 0 0.0 0.072 CA11 One 0.2 19q13.33 One 0 0 0 One 0 0.0 0.072 CCDC142 One 0.2 2p13.1 0 One 0 0 One 0 0.0 0.072 CCDC7 3 0.7 10p11.22 0 3 0 0 2 One 33.3 0.015 CD40 One 0.2 20q13.12 0 One 0 0 One 0 0.0 0.072 CDC6 One 0.2 17q21.2 0 One 0 0 One 0 0.0 0.072 CDK19 One 0.2 6q21 0 One 0 0 One 0 0.0 0.072 CDK5RAP1 One 0.2 20q11.21 0 One 0 0 One 0 0.0 0.072 CERK One 0.2 22q13.31 0 One 0 0 One 0 0.0 0.072 CERS3 One 0.2 15q26.3 0 One 0 0 One 0 0.0 0.072 CHGA One 0.2 14q32.12 One 0 0 0 One 0 0.0 0.072 CLK1 2 0.4 2q33.1 0 2 0 0 One One 50.0 0.139 CLUH One 0.2 17p13.3 One 0 0 0 One 0 0.0 0.072 COL15A1 One 0.2 9q22.33 0 One 0 0 One 0 0.0 0.072 COL28A1 One 0.2 7p21.3 0 One 0 0 One 0 0.0 0.072 CSTB One 0.2 21q22.3 0 One 0 0 One 0 0.0 0.072 CXorf67 One 0.2 Xp11.22 0 One 0 0 One 0 0.0 0.072

gene mutation
Number mutation
(%) Saito
band Mutation type age Fisher's exact
(P-Value) cut missense in-frame Etc I II+III+IV II+III+IV (%) CYP3A43 One 0.2 7q22.1 0 One 0 0 One 0 0.0 0.072 DAK One 0.2 11q12.2 One 0 0 0 One 0 0.0 0.072 DCP2 One 0.2 5q22.2 0 One 0 0 One 0 0.0 0.072 DPRX One 0.2 19q13.42 0 One 0 0 One 0 0.0 0.072 DYRK1A 2 0.4 21q22.13 0 2 0 0 One One 50.0 0.139 EHBP1L1 One 0.2 11q13.1 0 One 0 0 One 0 0.0 0.072 EPHA5 One 0.2 4q13.1-q13.2 0 One 0 0 One 0 0.0 0.072 ETNPPL 3 0.7 4q25 0 3 0 0 2 One 33.3 0.015 FAM13A One 0.2 4q22.1 0 One 0 0 One 0 0.0 0.072 FAM53B One 0.2 10q26.13 0 One 0 0 One 0 0.0 0.072 FASTKD2 3 0.7 2q33.3 One 2 0 0 2 One 33.3 0.015 FGF21 One 0.2 19q13.33 0 One 0 0 One 0 0.0 0.072 FHIT One 0.2 3p14.2 0 One 0 0 One 0 0.0 0.072 FIGF One 0.2 Xp22.2 0 One 0 0 One 0 0.0 0.072 FOXE1 2 0.4 9q22.33 0 0 2 0 2 0 0.0 0.005 FPR2 2 0.4 19q13.41 0 2 0 0 One One 50.0 0.139 GIMAP5 One 0.2 7q36.1 0 One 0 0 One 0 0.0 0.072 GOLGA3 2 0.4 12q24.33 One One 0 0 2 0 0.0 0.005 OR52N5 2 0.4 11p15.4 2 0 0 0 2 0 0.0 0.005 PBX4 4 0.9 19p13.11 2 2 0 0 2 2 50.0 0.029

gene mutation
Number Mutation (%) Saito
band type of mutation age Fisher's exact
(P-Value) cut missense in-frame Etc I II+III+IV II+III+IV
(%) PI4KB 2 0.4 1q21.3 0 2 0 0 2 0 0.0 0.005 PPP1R3B 2 0.4 8p23.1 0 2 0 0 2 0 0.0 0.005 SBNO2 2 0.4 19p13.3 2 0 0 0 2 0 0.0 0.005 ST5 3 0.7 11p15.4 0 3 0 0 2 One 33.3 0.015

As a result of the analysis, when compared between groups, ADAM11, AGK, FOXE1, GOLGA3, OR52N5, PI4KB, PPP1R3B , SBNO2, CCDC7, ETNPPL, FASTKD2, PBX4 and ST5 had a P-value of less than 0.05, which correlated with the occurrence of mutations in these genes with age. was confirmed to be related.

2 shows the results of analyzing the correlation between mutations in genes and age. As can be seen from Figure 2, ADAM11, AGK, FOXE1, GOLGA3, OR52N5, PI4KB, PPP1R3B and SBNO2 were confirmed to have a large number of patients with mutated genes in group I, and CCDC7, ETNPPL, FASTKD2, PBX4 and ST5 were found in group I It was confirmed that the number of patients with the mutated gene in the remaining groups except for

From the above results, it can be seen that 13 mutations of ADAM11, AGK, FOXE1, GOLGA3, OR52N5, PI4KB, PPP1R3B , SBNO2, CCDC7, ETNPPL, FASTKD2, PBX4 and ST5 can be used as age-specific group I and other group-specific markers. have.

2-3. Comparative analysis of Ⅰ+ Ⅱ group and Ⅲ + Ⅳ group (age group Ⅰ + Ⅱ vs Ⅲ + Ⅳ)

Among the four age groups divided by group in Table 2, for age group I+II and age group III+IV, the correlation between the occurrence of mutations in candidate genes and the age of prostate cancer patients was confirmed. A P-value of less than 0.05 was considered statistically significant. Information of candidate genes related to Table 11 and Table 12 is shown below.

gene mutation
Number Mutation (%) Saito
band type of mutation age Fisher's exact (P-Value) cut missense in-frame Etc I+II III+IV III+IV
(%) AASS 3 0.7 7q31.32 One 2 0 0 3 0 0.0 0.092 ADAM12 3 0.7 10q26.2 One 2 0 0 3 0 0.0 0.092 ADAMTS14 3 0.7 10q22.1 One 2 0 0 3 0 0.0 0.092 AGAP4 4 0.9 10q11.22 0 One 3 0 4 0 0.0 0.042 C10orf90 4 0.9 10q26.2 One 3 0 0 4 0 0.0 0.042 CSRNP1 3 0.7 3p22.2 One One One 0 3 0 0.0 0.092 CTCF 3 0.7 16q22.1 0 3 0 0 3 0 0.0 0.092 ETV3 5 1.1 1q23.1 2 3 0 0 0 5 100.0 0.052 FAM135B 5 1.1 8q24.23 0 5 0 0 0 5 100.0 0.052 FAM155A 3 0.7 13q33.3 0 3 0 0 3 0 0.0 0.092 GPR125 4 0.9 4p15.2 0 4 0 0 4 0 0.0 0.042 INO80 5 1.1 15q15.1 One 4 0 0 0 5 100.0 0.052 LINGO2 7 1.5 9p21.2-p21.1 One 6 0 0 0 7 100.0 0.019 MAMLD1 3 0.7 Xq28 0 3 0 0 3 0 0.0 0.092 MYO9A 11 2.4 15q23 0 11 0 0 0 11 100.0 0.003 NLRP4 5 1.1 19q13.43 0 5 0 0 0 5 100.0 0.052 NOS1 3 0.7 12q24.22 0 3 0 0 3 0 0.0 0.092 NOTCH2 12 2.6 1p12 8 4 0 0 One 11 91.7 0.09 PCDHB4 6 1.3 5q31.3 3 3 0 0 0 6 100.0 0.029 PTPN3 3 0.7 9q31.3 0 3 0 0 3 0 0.0 0.092

gene mutation
Number mutation
(%) Saito
band type of mutation age Fisher's exact (P-Value) cut missense in-frame Etc I+II III+IV III+IV (%) RAPGEF4 3 0.7 2q31.1 0 3 0 0 3 0 0.0 0.092 RETSAT 4 0.9 2p11.2 0 4 0 0 3 One 25.0 0.244 SP8 5 1.1 7p21.1 0 One 4 0 0 5 100.0 0.052 ST5 3 0.7 11p15.4 0 3 0 0 3 0 0.0 0.092 TBX18 4 0.9 6q14.3 0 4 0 0 4 0 0.0 0.042 TDP1 3 0.7 14q32.11 0 3 0 0 3 0 0.0 0.092 THSD4 5 1.1 15q23 0 5 0 0 0 5 100.0 0.052 TMEM132B 4 0.9 12q24.31-q24.32 0 4 0 0 4 0 0.0 0.042 TMEM52 4 0.9 1p36.33 0 0 4 0 4 0 0.0 0.042 TRIM67 3 0.7 1q42.2 0 3 0 0 3 0 0.0 0.092 USP31 5 1.1 16p12.2 One 4 0 0 0 5 100.0 0.052

As a result of the analysis, when compared between groups, AGAP4, C10orf90, CPR125, LINGO2, MYO9A, PCDHB4, TBX18, TMEM132B and TMEM52 had a P-value of less than 0.05.

3 shows the results of analyzing the association between mutations in genes and age. As can be seen from FIG. 3 , it was confirmed that the number of patients with mutated genes in age group I+II was large for AGAP4, C10orf90, CPR125, TBX18, TMEM132B and TMEM52. In addition, it was confirmed that LINGO2, MYO9A and PCDHB4 had a large number of patients with mutated genes in age group III + IV.

From the above results, it can be seen that the mutations of AGAP4, C10orf90, CPR125, LINGO2, MYO9A, PCDHB4, TBX18, TMEM132B and TMEM52 can be used as specific markers for differentiation between age group I+II and age group III+IV. .

2-4. Comparative analysis of Ⅰ+ Ⅱ + Ⅲ group and Ⅳ group (age group Ⅰ + Ⅱ +Ⅲ vs Ⅳ)

Among the four age groups divided by group in Table 2, the correlation between the occurrence of mutations in candidate genes and the age of prostate cancer patients was confirmed for the highest age (IV) and the remaining ages (I, II, and III). A P-value of less than 0.05 was considered statistically significant. Information on candidate genes related to Tables 13 to 17 is shown below.

gene mutation
Number Mutation (%) Saito
band Mutation type age Fisher's exact (P-Value) cut missense in-frame Etc I+II+III IV IV (%) ABCC10 3 0.6 6p21.1 One 2 0 0 0 3 100 0.0005 ABCC8 4 0.8 11p15.1 One 3 0 0 0 4 100 0.00004 ACTL6A 2 0.4 3q26.33 0 2 0 0 0 2 100 0.006 ADARB2 3 0.6 10p15.3 0 3 0 0 0 3 100 0.0005 AGBL1 3 0.6 15q25.3 0 3 0 0 0 3 100 0.0005 ALKBH1 2 0.4 14q24.3 0 2 0 0 0 2 100 0.006 AMPD2 4 0.8 1p13.3 0 4 0 0 0 4 100 0.00004 ANKRD30B 3 0.6 18p11.21 0 3 0 0 0 3 100 0.0005 APLP2 2 0.4 11q24.3 0 2 0 0 0 2 100 0.006 APOO 2 0.4 Xp22.11 0 2 0 0 0 2 100 0.006 ARHGAP10 2 0.4 4q31.23 One One 0 0 0 2 100 0.006 ARID3B 2 0.4 15q24.1 0 2 0 0 0 2 100 0.006 ASPH 2 0.4 8q12.3 0 2 0 0 0 2 100 0.006 ATNL1 2 0.4 10q25.3 0 2 0 0 0 2 100 0.006 B3GALT5 3 0.6 21q22.2 0 3 0 0 0 3 100 0.0005 B4GALT6 3 0.6 18q12.1 One 2 0 0 0 3 100 0.0005 BCR 2 0.4 22q11.23 0 2 0 0 0 2 100 0.006 BRD1 5 1.0 22q13.33 0 5 0 0 3 2 40 0.05 BTN2A2 2 0.4 6p22.2 0 2 0 0 0 2 100 0.006 C10orf12 2 0.4 10q24.1 0 2 0 0 0 2 100 0.006

gene mutation
Number mutation
(%) Saito
band gene type age Fisher's exact (P-Value) cut missense in-frame Etc I+II+III IV IV (%) C11orf24 2 0.4 11q13.2 0 2 0 0 0 2 100 0.006 C20orf194 4 0.8 20p13 0 4 0 0 One 3 75 0.002 C7orf57 2 0.4 7p12.3 One One 0 0 0 2 100 0.006 CABP1 One 0.2 12q24.31 0 One 0 0 0 One 100 0.08 CAMKK1 2 0.4 17p13.2 0 2 0 0 0 2 100 0.006 CD14 2 0.4 5q31.3 0 2 0 0 0 2 100 0.006 CELF3 2 0.4 1q21.3 One One 0 0 0 2 100 0.006 CERCAM 3 0.6 9q34.11 0 3 0 0 One 2 66.7 0.02 CHRNA6 6 1.2 8p11.21 3 3 0 0 One 5 83.3 0.00002 CLCN2 2 0.4 3q27.1 0 2 0 0 0 2 100 0.006 CLIP4 2 0.4 2p23.2 0 2 0 0 0 2 100 0.006 CLSTN1 3 0.6 1p36.22 One 2 0 0 0 3 100 0.0005 CRHR2 2 0.4 7p14.3 0 2 0 0 0 2 100 0.006 CRIM1 2 0.4 2p22.2 0 2 0 0 0 2 100 0.006 CRYBG3 2 0.4 3q11.2 0 2 0 0 0 2 100 0.006 CRYGN 2 0.4 7q36.1 0 2 0 0 0 2 100 0.006 CXorf56 2 0.4 Xq24 0 2 0 0 0 2 100 0.006 CYP2A6 3 0.6 19q13.2 One 2 0 0 One 2 66.7 0.02 CYP4F11 2 0.4 19p13.12 0 2 0 0 0 2 100 0.006 DCAF15 2 0.4 19p13.12 0 2 0 0 0 2 100 0.006

gene mutation
Number mutation
(%) Saito
band Mutation type age Fisher's exact (P-Value) cut missense in-frame Etc I+II+III IV IV (%) DET1 2 0.4 15q26.1 0 2 0 0 0 2 100 0.006 DHX16 2 0.4 6p21.33 0 2 0 0 0 2 100 0.006 DNA2 3 0.6 10q21.3 One 2 0 0 0 3 100 0.0005 DNAH6 2 0.4 2p11.2 0 2 0 0 0 2 100 0.006 DOCK11 4 0.8 Xq24 2 2 0 0 One 3 75 0.002 DPY19L2 8 1.6 12q14.2 0 8 0 0 3 5 62.5 0.0001 DYRK4 2 0.4 12p13.32 0 2 0 0 0 2 100 0.006 DYTN 2 0.4 2q33.3 One One 0 0 0 2 100 0.006 DZIP3 2 0.4 3q13.13 One One 0 0 0 2 100 0.006 EMC1 2 0.4 1p36.13 0 2 0 0 0 2 100 0.006 ENGASE 2 0.4 17q25.3 One 0 One 0 0 2 100 0.006 EPHA2 2 0.4 1p36.13 0 2 0 0 0 2 100 0.006 ERC2 4 0.8 3p14.3 0 2 2 0 2 2 50 0.03 ERI2 2 0.4 16p12.3 0 2 0 0 0 2 100 0.006 FDXR 2 0.4 17q25.1 0 2 0 0 0 2 100 0.006 FIGNL1 2 0.4 7p12.2 2 0 0 0 0 2 100 0.006 FOXP4 2 0.4 6p21.1 One One 0 0 0 2 100 0.006 FRMD6 2 0.4 14q22.1 0 2 0 0 0 2 100 0.006 FSCN2 2 0.4 17q25.3 0 2 0 0 0 2 100 0.006 FTMT 2 0.4 5q23.1 0 2 0 0 0 2 100 0.006

gene mutation
Number mutation
(%) Saito
band Mutation type age Fisher's exact (P-Value) cut missense in-frame Etc I+II+III IV IV (%) GABRA5 2 0.4 15q12 0 2 0 0 0 2 100 0.006 GEMIN4 2 0.4 17p13.3 One One 0 0 0 2 100 0.006 GIT2 2 0.4 12q24.11 0 2 0 0 0 2 100 0.006 GLYCTK 2 0.4 3p21.2 0 2 0 0 0 2 100 0.006 GLYR1 3 0.6 16p13.3 0 3 0 0 0 3 100 0.0005 GRK6 3 0.6 5q35.3 0 2 One 0 0 3 100 0.0005 HELB 8 1.6 12q14.3|12q 0 8 0 0 3 5 62.5 0.0001 HMGCLL1 2 0.4 6p12.1 0 2 0 0 0 2 100 0.006 HRG 2 0.4 3q27.3 0 2 0 0 0 2 100 0.006 IDE 2 0.4 10q23.33 One One 0 0 0 2 100 0.006 INTU 2 0.4 4q28.1 One One 0 0 0 2 100 0.006 IPO5 4 0.8 13q32.2 0 4 0 0 0 4 100 0.00004 ITPR1 4 0.8 3p26.1 One 3 0 0 0 4 100 0.00004 POGLUT2 2 0.4 13q33.1 0 2 0 0 0 2 100 0.006 KDM4B 4 0.8 19p13.3 2 2 0 0 One 3 75 0.002 KIAA0355 4 0.8 19q13.11 One 3 0 0 0 4 100 0.00004 SHISAL1 2 0.4 22q13.31 0 2 0 0 0 2 100 0.006 KIRREL2 2 0.4 19q13.12 0 2 0 0 0 2 100 0.006 KIT 3 0.6 4q12 One 2 0 0 0 3 100 0.0005 KLKB1 2 0.4 4q35.2 0 2 0 0 0 2 100 0.006

gene mutation
Number mutation
(%) Saito
band type of mutation age Fisher's exact (P-Value) cut missense in-frame Etc I+II+III IV IV (%) KRT37 2 0.4 17q21.2 0 2 0 0 0 2 100 0.006 KRT7 3 0.6 12q13.13 0 3 0 0 0 3 100 0.0005 LAD1 2 0.4 1q32.1 0 2 0 0 0 2 100 0.006 LETMD1 2 0.4 12q13.12 0 2 0 0 0 2 100 0.006 LRP3 3 0.6 19q13.11 0 3 0 0 0 3 100 0.0005 MAML2 2 0.4 11q21 0 2 0 0 0 2 100 0.006 MAP1B 2 0.4 5q13.2 0 2 0 0 0 2 100 0.006 MCM3AP 6 1.2 21q22.3 One 5 0 0 One 5 83.3 0.00002 METTL9 2 0.4 16p12.2 0 2 0 0 0 2 100 0.006 MICU1 2 0.4 10q22.1 0 2 0 0 0 2 100 0.006 MPDZ 3 0.6 9p23 0 3 0 0 0 3 100 0.0005 MYRIP 3 0.6 3p22.1 0 3 0 0 0 3 100 0.0005 NANP 2 0.4 20p11.21 0 2 0 0 0 2 100 0.006 NDST2 5 1.0 10q22.2 One 4 0 0 One 4 80 0.0002 NR3C2 3 0.6 4q31.23 0 3 0 0 0 3 100 0.0005 OR5B12 3 0.6 11q12.1 0 3 0 0 0 3 100 0.0005 SPTBN2 6 1.2 11q13.2 0 6 0 0 3 3 50 0.008 TAS1R2 4 0.8 1p36.13 0 4 0 0 One 3 75 0.002 ZMYM4 3 0.6 1p34.3 One 2 0 0 0 3 100 0.0005

As a result of the analysis, when compared between groups, ABCC10, ABCC8, ACTL6A, ADARB2, AGBL1, ALKBH1, AMPD2, ANKRD30B, APLP2, APOO, ARHGAP10, ARID3B, ASPH, ATRNL1, B3GALT5, B4GALT6, BCR, BRD1, BTNorf12, C11orf BRD1, BTNorf2A24 C20orf194, C7orf57, CAMKK1, CD14, CELF3, CERCAM, CHRNA6, CLCN2, CLIP4, CLSTN1, CRHR2, CRIM1, CRYBG3, CRYGN, CXorf56, CYP2A6, CYP4F11, DCAFLX16, DETDP2, DNAH19DHLX16, DETDP2, DYCK4 DYTN, DZIP3, EMC1, ENGASE, EPHA2, ERC2, ERI2, FDXR, FIGNL1, FOXP4, FRMD6, FSCN2, FTMT, GABRA5, GEMIN4, GIT2, GLYCTK, GLYR1, GRK6, HELB, HMGCLL1, HRG ITPR1, POGLUT2, KDM4B, KIAA0355, SHISAL1, KIRREL2, KIT, KLKB1, KRT37, KRT7, LAD1, LETMD1, LRP3, MAML2, MAP1B, MCM3AP, METTL9, MICU1, MP12DZ, MYRIP, NA SPNP, MYRIP, NA TAS1R2 and ZMYM4 had a P-value of less than 0.05, confirming that the mutagenesis of these genes and age were correlated.

4 shows the results of analyzing the association between mutations in genes and age. As can be seen from Figure 4, ABCC10, ABCC8, ACTL6A, ADARB2, AGBL1, ALKBH1, AMPD2, ANKRD30B, APLP2, APOO, ARHGAP10, ARID3B, ASPH, ATRNL1, B3GALT5, B4GALT6, BCR, BRD1, BTN2A2, C10orf12, C11f BRD1, C10orf12, C7orf57, CAMKK1, CD14, CELF3, CERCAM, CHRNA6, CLCN2, CLIP4, CLSTN1, CRHR2, CRIM1, CRYBG3, CRYGN, CXorf56, CYP2A6, TNCYP4F11, DCYAF15, DET1, DHX6, DOCK11, DNA2 DZIP3, EMC1, ENGASE, EPHA2, ERC2, ERI2, FDXR, FIGNL1, FOXP4, FRMD6, FSCN2, FTMT, GABRA5, GEMIN4, GIT2, GLYCTK, GLYR1, GRK6, HELB, HMGCLL1, HRG, IDE, INTU, IPO, IDE, POGLUT2, KDM4B, KIAA0355, SHISAL1, KIRREL2, KIT, KLKB1, KRT37, KRT7, LAD1, LETMD1, LRP3, MAML2, MAP1B, MCM3AP, METTL9, MICU1, MPDZ, MYRIP, NANP, ND TAS12, RNR3C, and ND ZMYM4 was confirmed to have a large number of patients with a mutated gene in age group IV.

From the above results, ABCC10, ABCC8, ACTL6A, ADARB2, AGBL1, ALKBH1, AMPD2, ANKRD30B, APLP2, APOO, ARHGAP10, ARID3B, ASPH, ATRNL1, B3GALT5, B4G24ALT6, BCR, BRD1, C20orf5712, C11orf CAMKK1, CD14, CELF3, CERCAM, CHRNA6, CLCN2, CLIP4, CLSTN1, CRHR2, CRIM1, CRYBG3, CRYGN, CXorf56, CYP2A6, CYP4F11, DCAF15, DET1, DHX16, DY, DZRK4, DNAH6, DOCKL EMC1, ENGASE, EPHA2, ERC2, ERI2, FDXR, FIGNL1, FOXP4, FRMD6, FSCN2, FTMT, GABRA5, GEMIN4, GIT2, GLYCTK, GLYR1, GRK6, HELB, HMGCLL1, HRUTG, IDE, INTU, POGL5 KDM4B, KIAA0355, SHISAL1, KIRREL2, KIT, KLKB1, KRT37, KRT7, LAD1, LETMD1, LRP3, MAML2, MAP1B, MCM3AP, METTL9, MICU1, MPDZ, MYRIP, NANP, SPTBN2, TMMY, NR3C Z2, OR5B12 It can be seen that the mutation can be used as a specific marker for differentiation between age group I+II+III and age group IV.

Example 3. Confirmation of utility as a survival-specific marker according to age

Among the candidate genes of Example 1, it was confirmed whether there was a survival-specific mutant gene. The 498 target patients obtained in Example 1 were classified into surviving patients (488 patients) and deceased patients (10 patients), and based on the clinical information (event (death or recurrence), observation time) obtained in Example 1 Overall survival kaplan-meier estimate and disease free survival kaplan-meier estimate were obtained using the Kaplan Meier survival assay (Spss 21). In the total survival period, death was determined as an event, and in the disease-free survival period, prostate cancer recurrence was determined as an event. In order to determine whether the occurrence of mutations in each of the above genes is correlated with the death or recurrence of prostate cancer in patients with recurrent prostate cancer, the event time (event time) for each group obtained in the Kaplan Meier survival assay time), the association between the occurrence of mutations and the total survival period, and the association between the occurrence of mutations and the disease-free survival period were confirmed by a log rank test. A P-value of less than 0.05 was considered statistically significant. The experimental group was the case with alterations in query gene, and the control group was the case without alterations in query gene. The median months survival means a value located at the center when the survival period of patients in the corresponding group is listed. The median disease-free survival period (median months desease free) means a value located at the center when the survival period of patients in the relevant group is listed. The slope in the survival curve by the Kaplan Meier survival assay is determined by the duration of survival.

In order to determine whether the occurrence of mutations in each of the candidate genes is associated with the survival rate of prostate cancer patients of known age (null hypothesis), the prognosis of 498 prostate cancer patients obtained in Example 1 was analyzed.

3-1. Comparative analysis between each group (age group Ⅰvs Ⅱ vs Ⅲ vs Ⅳ)

For each of the four age groups divided by group in Table 2, the association between the occurrence of mutations in candidate genes and the survival rate of prostate cancer patients of a specific age was confirmed. A P-value of less than 0.05 was considered statistically significant. Table 18 shows the p-values of total survival and disease-free survival between ages.

gene total survival disease free survival ABCC10 0.894 0.01 ACTL6A 0.894 0.045 ADARB2 0.9 0.001 ANKRD30B 0.894 0.0124 ARHGAP10 0.001 0.00000006 ASPH 0.001 0.00000006 ATNL1 0.894 0.03 C11orf24 0.9 0.001 CABP1 0.9 0.001 CAMKK1 0.9 0.004 CD14 0.9 0.001 CELF3 0.9 0.001 CLCN2 0.9 0.001 CLIP4 0.859 0.0006 CRIM1 0.9 0.005 CXorf56 0.9 0.005 CYP4F11 0.9 0.003 DYTN 0.894 0.01 FIGNL1 0.846 0.001 FOXE1 0.0000005 0.325 FSCN2 0.9 0.003 FTMT 0.9 0.003 ITPR1 0.004 0.004 PI4KB 0.747 0.047

Between groups, ABCC10, ACTL6A, ADARB2, ANKRD30B, ARHGAP10, ASPH, ATRNL1, C11orf24, CAMKK1, CD14, CELF3, CLCN2, CLIP4, CRIM1, CXorf56, FTCYP4F11, DYTN, FIG1NL1, FOXE, FIG1NL1 and FOXE The probability that the null hypothesis that the PI4KB gene mutation is related to the survival rate of age group IV among prostate cancer patients is more than 99.5%, that is, the probability that the null hypothesis is false is less than 0.5%, ABCC10, ACTL6A, ADARB2, ANKRD30B, ARHGAP10, ASPH, ATRNL1, C11orf24, CAMKK1, CD14, CELF3, CLCN2, CLIP4, CRIM1, CXorf56, CYP4F11, DYTN, FIGNL1, FOXE1, FSCN2, FTMT, ITPR1 and PI4KB genes among patients with age-related mutations and prostate cancer It can be seen that there is a correlation with the survival rate of IV.

3-2. Comparative analysis of group Ⅰ and other groups (age group Ⅰ vs Ⅱ + Ⅲ + Ⅳ)

In Table 2, the association between the occurrence of mutations in candidate genes and the survival rate of prostate cancer patients of a certain age was confirmed for the lowest age (I) and the remaining ages (II, III, and IV) among groups classified in Table 2. A P-value of less than 0.05 was considered statistically significant. Table 19 shows the p-values of the total survival and disease-free survival of age group I and age group II + III + IV.

gene total survival disease free survival AKR1D1 0.794 0.0314 AQP12A 2E-07 0.2 CA10 0.794 0.0314 COL28A1 2E-07 0.2 FOXE1 5E-07 0.325 PI4KB 0.747 0.047

FOXE1 and PI4KB gene FOXE1 and PI4KB genes have a greater than 99.5% probability of being correct, that is, less than 0.5% of false null hypothesis, indicating that mutations in FOXE1 and PI4KB genes are associated with the survival rate of age grade I among prostate cancer patients. It can be seen that there is a correlation between the occurrence of these mutations and the survival rate of patients with age grade I among prostate cancer patients.

3-3. Comparative analysis of Ⅰ+ Ⅱ group and Ⅲ + Ⅳ group (age group Ⅰ + Ⅱ vs Ⅲ + Ⅳ)

Among the four age groups divided by group in Table 2, for age group I+II and age group III+IV, the association between the occurrence of mutations in candidate genes and the survival rate of prostate cancer patients of a specific age was confirmed. A P-value of less than 0.05 was considered statistically significant. Table 20 shows the p-values of total survival and disease-free survival of age group I+II and age group III+IV.

gene total survival disease free survival AASS 0.00000007 0.403 ADAMTS14 0.812 0.0419

When comparing age group I+II and age group III+IV, the probability that the null hypothesis that the occurrence of gene mutations is related to the survival rate of age group I+II or age group III+IV is more than 99.5%, that is, the null hypothesis No gene has been identified with a probability of this error of less than 0.5%.

3-4. Comparative analysis of Ⅰ+ Ⅱ + Ⅲ and Ⅳ groups (age group Ⅰ + Ⅱ + Ⅲ vs Ⅳ)

In Table 2, the association between the occurrence of mutations in candidate genes and the survival rate of prostate cancer patients of a certain age for the highest age (IV) and the remaining ages (I, II and III) among the four age groups divided by group in Table 2 Confirmed. A P-value of less than 0.05 was considered statistically significant. P-values of total survival and disease-free survival between ages are shown in Tables 21 and 22.

gene total survival disease free survival ABCC10 0.894 0.0124 ACTL6A 0.894 0.0451 ADARB2 0.9 0.001452 ANKRD30B 0.894 0.0124 ARHGAP10 0.00127 6.25E-08 ASPH 0.00127 6.25E-08 ATNL1 0.894 0.0281 C11orf24 0.9 0.001452 CABP1 0.9 0.001452 CAMKK1 0.9 0.003932 CD14 0.9 0.001452 CELF3 0.9 0.001452 CLCN2 0.9 0.001452 CLIP4 0.859 0.000574 CRIM1 0.9 0.005006 CXorf56 0.9 0.005006 CYP4F11 0.9 0.002642 DYTN 0.894 0.0124 FIGNL1 0.846 0.001241 FSCN2 0.9 0.002642

gene total survival disease free survival FSCN2 0.9 0.002642 FTMT 0.9 0.002642 GLYCTK 0.9 0.005006 GLYR1 0.9 0.002642 INTU 0.894 0.0339 ITPR1 0.003671 0.004208 POGLUT2 0.9 0.002642 KDM4B 0.9 0.008233 KIAA0355 0.894 0.0124 SHISAL1 0.00127 6.25E-08 KIRREL2 0.9 0.005006 KLKB1 0.00127 6.25E-08 KRT37 0.894 0.0246 LETMD1 0.9 0.001452 MAML2 0.859 0.000574 MAP1B 0.894 0.0124 METTL9 0.9 0.003932

ABCC10, ACTL6A, ADARB2, ANKRD30B, ARHGAP10, ASPH, ATRNL1, C11orf24, CAMKK1, CD14, CELF3, CLCN2, CLIP4, CRIM1, CXorf56, CYP4F11, DYTN, FIGNL1, FSCN2, FTMT, POGLUTYC, ITPR, FTMT, POGLUT The probability of correcting the null hypothesis that mutations in the KDM4B, KIAA0355, SHISAL1, KIRREL2, KLKB1, KRT37, LETMD1, MAML2, MAP1B and METTL9 genes are associated with the survival rate of age grade IV among prostate cancer patients is greater than 99.5%, that is, null Less than 0.5% chance that the hypothesis is wrong, so ABCC10, ACTL6A, ADARB2, ANKRD30B, ARHGAP10, ASPH, ATRNL1, C11orf24, CAMKK1, CD14, CELF3, CLCN2, CLIP4, CRIM1, CXorf56, CYP4F11, FSCN2, FIGNL1, FSCN, FIGNL1 Mutations in the FTMT, GLYCTK, GLYR1, INTU, ITPR1, POGLUT2, KDM4B, KIAA0355, SHISAL1, KIRREL2, KLKB1, KRT37, LETMD1, MAML2, MAP1B, and METTL9 genes were correlated with the survival rate of age-grade IV prostate cancer patients. it can be seen that there is

3-4. Disease-free survival-specific genes

Among the candidate genes of Example 1, with respect to the genes identified in Examples 3-1, 3-2 and 3-3 as survival-specific mutant genes, ABCC10, ACTL6A, ADARB2, ANKRD30B, ATRNL1, C11orf24, CAMKK1, CD14, CELF3, CLCN2, CLIP4, CRIM1, CXorf56, CYP4F11, DYTN, FIGNL1, FSCN2, FTMT, GLYCTK, GLYR1, INTU, POGLUT2, KDM4B, KIRREL1, MAML55, LET1, KIAA032 METTL9 and P14KB were identified. The corresponding results for each gene are shown below.

As can be seen from FIG. 5 , in the case of prostate cancer patients in which the ABCC10 gene mutation did not occur, more than 50% of the ABCC10 survived more than 80 months (blue), whereas the ABCC10 gene mutation occurred in prostate cancer patients. Since more than 50% of prostate cancer patients died before 20 months of age, it was confirmed that the survival rate was lower than that of non-mutagenic prostate cancer patients (red). Therefore, if there is a mutation in the ABCC10 gene and the age group of the prostate cancer patient is group IV, the probability of death from prostate cancer increases. can

As can be seen in FIG. 6 , ACTL6A survives more than 80 months in the case of prostate cancer patients in which the ACTL6A gene is not mutated (blue), whereas in the case of prostate cancer patients in which the ACTL6A gene mutation occurs, Since more than 50% of prostate cancer patients died before 20 months of age, it was confirmed that the survival rate was lower than that of non-mutagenic prostate cancer patients (red). Therefore, if there is a mutation in the ACTL6A gene and the probability of death from prostate cancer increases in the case of age group IV of prostate cancer patients, it can be seen that the mutation in the ACTL6A gene is significant as a survival rate predictive marker of prostate cancer patients in age group IV. have.

As can be seen from FIG. 7 , ADARB2 in the case of prostate cancer patients in which the mutation in the ADARB2 gene does not occur, 50% or more survived for more than 80 months (blue), whereas in the case of prostate cancer patients in which the mutation in the ADARB2 gene occurs, the Since more than 50% of prostate cancer patients died before 20 months of age, it was confirmed that the survival rate was lower than that of non-mutagenic prostate cancer patients (red). Therefore, if there is a mutation in the ADARB2 gene and the probability of death from prostate cancer increases in the case of age group IV of prostate cancer patients, it can be seen that the mutation in the ADARB2 gene is significant as a survival rate predictive marker of prostate cancer patients in age group IV. have.

ANKRD30B, as can be seen in FIG. 8, in the case of prostate cancer patients in which the mutation in the ANKRD30B gene did not occur, 50% or more survived for more than 80 months (blue), whereas the prostate cancer patients in which the mutation in the ANKRD30B gene occurred were Since more than 50% of prostate cancer patients died before 20 months of age, it was confirmed that the survival rate was lower than that of non-mutagenic prostate cancer patients (red). Therefore, if there is a mutation in the ANKRD30B gene and the age group of the prostate cancer patient is group IV, the probability of death from prostate cancer increases. can

As can be seen in FIG. 9, ATRNL1 is a prostate cancer patient with a mutation in the ATRNL1 gene, whereas 50% or more of the prostate cancer patients in which the ATRNL1 gene mutation does not occur survive for more than 80 months (blue). Since more than 50% of prostate cancer patients died before 20 months of age, it was confirmed that the survival rate was lower than that of non-mutagenic prostate cancer patients (red). Therefore, if there is a mutation in the ATRNL1 gene and the age group of the prostate cancer patient is group IV, the probability of death from prostate cancer increases. can

As can be seen from FIG. 10 , C11orf24 is a prostate cancer patient with a mutation in the C11orf24 gene, whereas 50% or more of the patients with prostate cancer in which the mutation does not occur for 80 months or more survived (blue). Since more than 50% of prostate cancer patients died before 20 months of age, it was confirmed that the survival rate was lower than that of non-mutagenic prostate cancer patients (red). Therefore, it can be seen that the mutation of the C11orf24 gene is significant as a survival rate predictive marker for prostate cancer patients in age group IV because the probability of death from prostate cancer increases when there is a mutation in the C11orf24 gene and the age group IV of prostate cancer patients. have.

As can be seen in FIG. 11 , CAMKK1 is more than 50% of patients with prostate cancer in which the mutation in the CAMKK1 gene does not occur for more than 80 months (blue), whereas prostate cancer patients in which the mutation in the CAMKK1 gene has occurred Since more than 50% of prostate cancer patients died before the age of 20 months, it was confirmed that the survival rate was lower than that of prostate cancer patients without mutation (red). Therefore, if there is a mutation in the CAMKK1 gene and the age group of the prostate cancer patient is group IV, the probability of death from prostate cancer increases. can

As can be seen from FIG. 12, in the case of prostate cancer patients in which CD14 gene mutation did not occur, more than 50% of CD14 patients survived over 80 months (blue), whereas prostate cancer patients in which CD14 gene mutation occurred Since more than 50% of prostate cancer patients died before the age of 20 months, it was confirmed that the survival rate was lower than that of prostate cancer patients without mutation (red). Therefore, if there is a mutation in the CD14 gene and the age group of the prostate cancer patient is group IV, the probability of death from prostate cancer increases. can

As can be seen from FIG. 13, in the case of CELF3 gene mutation, more than 50% of patients with prostate cancer in which the mutation did not occur in CELF3 survived more than 80 months (blue), whereas prostate cancer patients in which the mutation in the CELF3 gene occurred Since more than 50% of prostate cancer patients died before 20 months of age, it was confirmed that the survival rate was lower than that of non-mutagenic prostate cancer patients (red). Therefore, if there is a mutation in the CELF3 gene and the age group of the prostate cancer patient is group IV, the probability of death from prostate cancer increases. can

As can be seen from FIG. 14 , CLCN2 in the case of prostate cancer patients in which the CLCN2 gene mutation did not occur, 50% or more survived for more than 80 months (blue), whereas the CLCN2 gene mutation occurred in prostate cancer patients. Since more than 50% of prostate cancer patients died before 20 months of age, it was confirmed that the survival rate was lower than that of non-mutagenic prostate cancer patients (red). Therefore, if there is a mutation in the CLCN2 gene and the age group of the prostate cancer patient is group IV, the probability of death from prostate cancer increases. can

As can be seen from FIG. 15, CLIP4 is more than 50% of patients with prostate cancer in which the CLIP4 gene is not mutated survives for more than 80 months (blue), whereas in the case of prostate cancer patients in which the CLIP4 gene is mutated, Since more than 50% of prostate cancer patients died before 40 months of age, it was confirmed that the survival rate was lower than that of non-mutated prostate cancer patients (red). Therefore, if there is a mutation in the CLIP4 gene and the age group of the prostate cancer patient is group IV, the probability of death from prostate cancer increases. can

As can be seen from FIG. 16 , CRIM1 in the case of prostate cancer patients in which the CRIM1 gene mutation did not occur, more than 50% survived more than 80 months (blue), whereas the CRIM1 gene mutation in the prostate cancer patients Since more than 50% of prostate cancer patients died before the age of 20 months, it was confirmed that the survival rate was lower than that of prostate cancer patients without mutation (red). Therefore, if there is a mutation in the CRIM1 gene and the age group of the prostate cancer patient is group IV, the probability of death from prostate cancer increases. can

As can be seen in FIG. 17 , in the case of CXorf56, in the case of prostate cancer patients in which the CXorf56 gene mutation did not occur, 50% or more survived for more than 80 months (blue), whereas the CXorf56 gene mutation occurred in prostate cancer patients. Since more than 50% of prostate cancer patients died before 20 months of age, it was confirmed that the survival rate was lower than that of non-mutagenic prostate cancer patients (red). Therefore, if there is a mutation in the CXorf56 gene and the age group of the prostate cancer patient is group IV, the probability of death from prostate cancer increases. can

As can be seen from FIG. 18 , in CYP4F11, more than 50% of prostate cancer patients in which the CYP4F11 gene mutation did not occur survived more than 80 months (blue), whereas the CYP4F11 gene mutation occurred in prostate cancer patients. Since more than 50% of prostate cancer patients died before 20 months of age, it was confirmed that the survival rate was lower than that of non-mutagenic prostate cancer patients (red). Therefore, if there is a mutation in the CYP4F11 gene and the age group of the prostate cancer patient is group IV, the probability of death from prostate cancer increases. can

As can be seen in FIG. 19 , DYTN is a prostate cancer patient with a mutation in the DYTN gene, whereas 50% or more of the prostate cancer patients without mutation in the DYTN gene survive for more than 80 months (blue). Since more than 50% of prostate cancer patients died before 20 months of age, it was confirmed that the survival rate was lower than that of non-mutagenic prostate cancer patients (red). Therefore, if there is a mutation in the DYTN gene and the age group of the prostate cancer patient is group IV, the probability of death from prostate cancer increases. can

As can be seen in FIG. 20 , in FIG. 20 , 50% or more of patients with prostate cancer in which the FIGNL1 gene is not mutated survived for more than 80 months (blue), whereas those of prostate cancer patients in which the FIGNL1 gene is mutated survived. Since more than 50% of prostate cancer patients died before 40 months of age, it was confirmed that the survival rate was lower than that of non-mutated prostate cancer patients (red). Therefore, if there is a mutation in the FIGNL1 gene and the age group of the prostate cancer patient is group IV, the probability of death from prostate cancer increases. can

FSCN2, as can be seen in FIG. 21, in the case of prostate cancer patients in which the FSCN2 gene mutation did not occur, more than 50% survived for more than 80 months (blue), whereas the FSCN2 gene mutation occurred in prostate cancer patients Since more than 50% of prostate cancer patients died before 20 months of age, it was confirmed that the survival rate was lower than that of non-mutagenic prostate cancer patients (red). Therefore, if there is a mutation in the FSCN2 gene and the age group of the prostate cancer patient is group IV, the probability of death from prostate cancer increases. can

As can be seen from FIG. 22 , FTMT is more than 50% of prostate cancer patients with no mutation in the FTMT gene survived for more than 80 months (blue), whereas prostate cancer patients with mutation in the FTMT gene are Since more than 50% of prostate cancer patients died before 20 months of age, it was confirmed that the survival rate was lower than that of non-mutagenic prostate cancer patients (red). Therefore, if there is a mutation in the FTMT gene and the age group of the prostate cancer patient is group IV, the probability of death from prostate cancer increases. can

GLYCTK, as can be seen in FIG. 23, in the case of prostate cancer patients without mutation in the GLYCTK gene, 50% or more survived for more than 80 months (blue), whereas prostate cancer patients in which the mutation in the GLYCTK gene occurs Since more than 50% of prostate cancer patients died before 20 months of age, it was confirmed that the survival rate was lower than that of non-mutagenic prostate cancer patients (red). Therefore, if there is a mutation in the GLYCTK gene and the age group of the prostate cancer patient is group IV, the probability of death from prostate cancer increases. can

As can be seen from FIG. 24 , in the case of GLYR1 gene mutation, more than 50% of patients with prostate cancer in which the GLYR1 gene is not mutated survived more than 80 months (blue), whereas the GLYR1 gene mutation occurred in prostate cancer patients. Since more than 50% of prostate cancer patients died before 20 months of age, it was confirmed that the survival rate was lower than that of non-mutagenic prostate cancer patients (red). Therefore, if there is a mutation in the GLYR1 gene and the age group of the prostate cancer patient is group IV, the probability of death from prostate cancer increases. can

As can be seen in FIG. 25, INTU is a prostate cancer patient with a mutation in the INTU gene, whereas 50% or more survives for more than 80 months (blue) in the case of prostate cancer patients with no mutation in the INTU gene. Since more than 50% of prostate cancer patients died before 20 months of age, it was confirmed that the survival rate was lower than that of non-mutagenic prostate cancer patients (red). Therefore, if there is a mutation in the INTU gene and the age group of the prostate cancer patient is group IV, the probability of death from prostate cancer increases. can

As can be seen from FIG. 26 , POGLUT2 is more than 50% of patients with prostate cancer in which the mutation in the POGLUT2 gene does not occur for more than 80 months (blue), whereas the prostate cancer patient in which the mutation in the POGLUT2 gene is Since more than 50% of prostate cancer patients died before 20 months of age, it was confirmed that the survival rate was lower than that of non-mutagenic prostate cancer patients (red). Therefore, if there is a mutation in the POGLUT2 gene and the age group of the prostate cancer patient is group IV, the probability of death from prostate cancer increases. can

As can be seen in FIG. 27 , in the case of prostate cancer patients in which the KDM4B gene mutation does not occur, 50% or more of KDM4B survives for more than 80 months (blue), whereas the KDM4B gene mutation occurs in prostate cancer patients. Since more than 50% of prostate cancer patients died before 20 months of age, it was confirmed that the survival rate was lower than that of non-mutagenic prostate cancer patients (red). Therefore, if there is a mutation in the KDM4B gene and the age group of the prostate cancer patient is group IV, the probability of death from prostate cancer increases. can

As can be seen from FIG. 28 , in KIAA0355, in the case of prostate cancer patients in which the KIAA0355 gene mutation did not occur, 50% or more survived for more than 80 months (blue), whereas the KIAA0355 gene mutation occurred in prostate cancer patients. Since more than 50% of prostate cancer patients died before 20 months of age, it was confirmed that the survival rate was lower than that of non-mutagenic prostate cancer patients (red). Therefore, if there is a mutation in the KIAA0355 gene and the age group of the prostate cancer patient is group IV, the probability of death from prostate cancer increases. can

As can be seen from FIG. 29 , KIRREL2 in the case of prostate cancer patients in which the mutation in the KIRREL2 gene did not occur, 50% or more survived for more than 80 months (blue), whereas in the case of prostate cancer patients in which the mutation in the KIRREL2 gene occurred, Since more than 50% of prostate cancer patients died before 20 months of age, it was confirmed that the survival rate was lower than that of non-mutagenic prostate cancer patients (red). Therefore, if there is a mutation in the KIRREL2 gene and the age group of the prostate cancer patient is group IV, the probability of death from prostate cancer increases. can

As can be seen from FIG. 30 , in the case of KRT37, more than 50% of prostate cancer patients in which the KRT37 gene mutation did not occur survived for more than 80 months (blue), whereas the prostate cancer patients in which the KRT37 gene mutation occurred were Since more than 50% of prostate cancer patients died before 20 months of age, it was confirmed that the survival rate was lower than that of non-mutagenic prostate cancer patients (red). Therefore, if there is a mutation in the KRT37 gene and the age group of the prostate cancer patient is group IV, the probability of death from prostate cancer increases. can

As can be seen from FIG. 31 , LETMD1 in the case of prostate cancer patients in which the LETMD1 gene mutation did not occur, 50% or more survived for more than 80 months (blue), whereas the LETMD1 gene mutation occurred in prostate cancer patients Since more than 50% of prostate cancer patients died before 20 months of age, it was confirmed that the survival rate was lower than that of non-mutagenic prostate cancer patients (red). Therefore, if there is a mutation in the LETMD1 gene and the age group of the prostate cancer patient is group IV, the probability of death from prostate cancer increases. can

In MAML2, as can be seen in FIG. 32 , in the case of prostate cancer patients in which the MAML2 gene mutation does not occur, 50% or more survive for more than 80 months (blue), whereas the MAML2 gene mutation occurs in prostate cancer patients. Since more than 50% of prostate cancer patients died before 30 months of age, it was confirmed that the survival rate was lower than that of non-mutated prostate cancer patients (red). Therefore, if there is a mutation in the MAML2 gene and the age group of the prostate cancer patient is group IV, the probability of death from prostate cancer increases. can

As can be seen from FIG. 33 , MAP1B is more than 50% of patients with prostate cancer in which the mutation in the MAP1B gene does not occur for more than 80 months (blue), whereas prostate cancer patients in which the mutation in the MAP1B gene has occurred Since more than 50% of prostate cancer patients died before the age of 20 months, it was confirmed that the survival rate was lower than that of prostate cancer patients without mutation (red). Therefore, if there is a mutation in the MAP1B gene and the age group of the prostate cancer patient is group IV, the probability of death from prostate cancer increases. can

METTL9, as can be seen in FIG. 34, in the case of prostate cancer patients in which the mutation in the METTL9 gene did not occur, 50% or more survived for more than 80 months (blue), whereas the prostate cancer patients in which the mutation in the METTL9 gene occurred Since more than 50% of prostate cancer patients died before 20 months of age, it was confirmed that the survival rate was lower than that of non-mutagenic prostate cancer patients (red). Therefore, if there is a mutation in the METTL9 gene and the age group of the prostate cancer patient is group IV, the probability of death from prostate cancer increases. can

As can be seen from FIG. 35 , P14KB in the case of prostate cancer patients in which the mutation in the P14KB gene did not occur, 50% or more survived for more than 80 months (blue), whereas the prostate cancer patients in which the mutation in the P14KB gene occurred were Since more than 50% of prostate cancer patients died before 20 months of age, it was confirmed that the survival rate was lower than that of non-mutagenic prostate cancer patients (red). Therefore, if there is a mutation in the P14KB gene and the age group of the prostate cancer patient is group IV, the probability of death from prostate cancer increases. can

3-5. Genes specific for total survival and disease-free survival

ARHGAP10, ASPH, ITPR1, SHISAL1 and KLKB1 were identified as total survival and disease-free survival-specific genes. The results corresponding to the following are shown.

As can be seen from FIG. 36, ARHGAP10 is more than 50% of patients with prostate cancer in which the mutation in the ARHGAP10 gene does not occur for more than 80 months (blue), whereas prostate cancer patients in which the mutation in the ARHGAP10 gene has occurred. Since more than 50% of prostate cancer patients died before 20 months of age, it was confirmed that the survival rate was lower than that of non-mutagenic prostate cancer patients (red). Therefore, if there is a mutation in the ARHGAP10 gene and the age group of the prostate cancer patient is group IV, the probability of death from prostate cancer increases. can

As can be seen from FIG. 37, in the case of ASPH, more than 50% of prostate cancer patients with no mutation in the ASPH gene survived for more than 80 months (blue), whereas prostate cancer patients with a mutation in the ASPH gene Since more than 50% of prostate cancer patients died before 20 months of age, it was confirmed that the survival rate was lower than that of non-mutagenic prostate cancer patients (red). Therefore, if there is a mutation in the ASPH gene and the age group of the prostate cancer patient is group IV, the probability of death from prostate cancer increases. can

As can be seen from FIG. 38 , ITPR1 is more than 50% of patients with prostate cancer in which the mutation in the ITPR1 gene does not occur for more than 80 months (blue), whereas the prostate cancer patient in which the mutation in the ITPR1 gene survives. Since more than 50% of prostate cancer patients died before 20 months of age, it was confirmed that the survival rate was lower than that of non-mutagenic prostate cancer patients (red). Therefore, if there is a mutation in the ITPR1 gene and the age group of the prostate cancer patient is group IV, the probability of death from prostate cancer increases. can

As can be seen from FIG. 39, in the case of SHISAL1 gene mutation, more than 50% of prostate cancer patients with no mutation in the SHISAL1 gene survived over 80 months (blue), whereas the SHISAL1 gene mutation occurred in prostate cancer patients. Since more than 50% of prostate cancer patients died before 20 months of age, it was confirmed that the survival rate was lower than that of non-mutagenic prostate cancer patients (red). Therefore, if there is a mutation in the SHISAL1 gene and the age group of the prostate cancer patient is group IV, the probability of death from prostate cancer increases. can

As can be seen from FIG. 40 , KLKB1 in the case of prostate cancer patients in which the mutation in the KLKB1 gene did not occur, 50% or more survived for more than 80 months (blue), whereas in the case of prostate cancer patients in which the mutation in the KLKB1 gene occurred, Since more than 50% of prostate cancer patients died before 20 months of age, it was confirmed that the survival rate was lower than that of non-mutagenic prostate cancer patients (red). Therefore, if there is a mutation in the KLKB1 gene and the age group of the prostate cancer patient is group IV, the probability of death from prostate cancer increases. can

3-6. Total Survival Specific Genes

FOXE1 was identified as a total survival-specific gene. The results are shown below.

As can be seen from FIG. 41 , FOXE1 is more than 50% of patients with prostate cancer in which the FOXE1 gene is not mutated survive for more than 80 months (blue), whereas prostate cancer patients in which the FOXE1 gene is mutated survived. Since more than 50% of prostate cancer patients died before 50 months of age, it was confirmed that the survival rate was lower than that of non-mutagenic prostate cancer patients (red). Therefore, if there is a mutation in the FOXE1 gene and the age group of the prostate cancer patient is group I, the probability of death from prostate cancer increases. can

Through the above results, ABCC10, ACTL6A, ADARB2, ANKRD30B, ARHGAP10, ASPH, ATRNL1, C11orf24, CAMKK1, CD14, CELF3, CLCN2, CLIP4, CRIM1, CXorf56, CYP IT4F11, DYTN, FIG1NL1, FOXE1 , GLYCTK, GLYR1, INTU, POGLUT2, KDM4B, KIAA0355, SHISAL1, KIRREL2, KLKB1, KRT37, LETMD1, MAML2, MAP1B and METTL9 survival rate of patients with recurrent prostate cancer when there is a mutation in any one gene selected from the group consisting of It can be seen that the prognosis of prostate cancer, in particular survival or recurrence, can be predicted by comparing whether the genes of the present invention are mutated or not in the patient's recurrence or not.

In the above, preferred embodiments of the present invention have been exemplarily described, but the scope of the present invention is not limited only to the specific embodiments as described above, and those of ordinary skill in the art will It will be possible to change it appropriately.

<110> Catholic University of Korea Industry-Academic Cooperation Foundation <120> Age-specific markers for diagnosing prognosis and determining treatment stratagies of patient of Prostate adenocarcinoma <130> PD20-065-D1 <160> 37 <170> KoPatentIn 3.0 <210> 1 <211> 5301 <212> DNA <213> ASPH <400> 1 agtcacaggt tcgtacacgc gaggccgggc gcgcgcagcc ggcaggcggg tgaagtcttc 60 ccaggtgctg caggcggtgc tgaggcacag ggtctgctgc aggagcagcg gcccgaaccc 120 gctccagcgg cccgccgccg ccagcggttc ccgcgtcgcg tgtgtacccc cgcgcactga 180 aggaggtccg ccagccctca ccagcccccg cggaccgtgc aatggcccag cgtaagaatg 240 ccaagagcag cggcaacagc agcagcagcg gctccggcag cggtagcacg agtgcgggca 300 gcagcagccc cggggcccgg agagagacaa agcatggagg acacaagaat gggaggaaag 360 gcggactctc aggaacttca ttcttcacgt ggtttatggt gattgcattg ctgggcgtct 420 ggacatctgt agctgtcgtt tggtttgatc ttgttgacta tgaggaagtt ctaggaaaac 480 taggaatcta tgatgctgat ggtgatggag attttgatgt ggatgatgcc aaagttttat 540 taggacttaa agagagatct acttcagagc cagcagtccc gccagaagag gctgagccac 600 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cctacctgat gtccctgcag acctgctgaa gctgagtttg aagcgtcgct 1500 cagacaggca acaatttcta ggtcatatga gaggttccct gcttaccctg cagagattag 1560 ttcaactatt tcccaatgat acttccttaa aaaatgacct tggcgtggga tacctcttga 1620 taggagataa tgacaatgca aagaaagttt atgaagaggt gctgagtgtg acacctaatg 1680 atggctttgc taaagtccat tatggcttca tcctgaaggc acagaacaaa attgctgaga 1740 gcatcccata tttaaaggaa ggaatagaat ccggagatcc tggcactgat gatgggagat 1800 tttatttcca cctgggggat gccatgcaga gggttgggaa caaagaggca tataagtggt 1860 atgagcttgg gcacaagaga ggacactttg catctgtctg gcaacgctca ctctacaatg 1920 tgaatggact gaaagcacag ccttggtgga ccccaaaaga aacgggctac acagagttag 1980 taaagtcttt agaaagaaac tggaagttaa tccgagatga aggccttgca gtgatggata 2040 aagccaaagg tctcttcctg cctgaggatg aaaacctgag ggaaaaaggg gactggagcc 2100 agttcacgct gtggcagcaa ggaagaagaa atgaaaatgc ctgcaaagga gctcctaaaa 2160 cctgtacctt actagaaaag ttccccgaga caacaggatg cagaagagga cagatcaaat 2220 attccatcat gcaccccggg actcacgtgt ggccgcacac agggcccaca aactgcaggc 2280 tccgaatgca cctgggcttg gtgattccca aggaaggctg caagattcga tgtgccaacg 2340 agaccaagac ctgggaggaa ggcaaggtgc tcatctttga tgactccttt gagcacgagg 2400 tatggcagga tgcctcatct ttccggctga tattcatcgt ggatgtgtgg catccggaac 2460 tgacaccaca gcagagacgc agccttccag caatttagca tgaattcatg caagcttggg 2520 aaactctgga gagaggctgc ctttctggtt ccatctcctt gggtgtgagg atagaatttc 2580 gaacaccaag agtcaattcc cttgacttgc agcccgagta attcaaagcc tcctcctagg 2640 gtcagaagac actaaaggga atatttgcct cgctgcaatt catttaggaa acaccctgct 2700 gtgtgtcatc tcatgacagc actggtcttc tgccagtatt taaggtgaac atttgatagc 2760 ttctacctta ccagccaaag atattttttc cacatagaat aggtctaatt caatgtataa 2820 tgagaacata tgtagaaact gtgaatggat tgctttagtt tgtaattttt ctatgcagtt 2880 atatttttct agtgtagcta gactattttg tcatcatgta ccactacatt tttgtttatt 2940 ttaatgacaa gctgtataaa tgctttactt ctagctattt aatggtagca ttactgggga 3000 actcagactt ccctctttta attcttctta gtaaaagata ctcatgaaaa aagcagtttt 3060 attttcctaa caaaaaagaa agagctcatt atgtcagtgt ctatgaactg tacccatccc 3120 aactctcaaa tcgtttggtt ttttttatct tgattgagat cctcttctca ctatgctagt 3180 ggtggagata ttgacaaaat cctatttctt tcaaagagga acttttcaca ccgaaaaaag 3240 agcatggaat tattttatat tgttataaaa atcccagatg caaatttttt taatgccaat 3300 tattagagct tctggggaaa aagtatagtt cacggaaata aaactatgtt ctttcagggt 3360 tgggtggata ggtggctgct agggtgtctg gctcctggcg gctttgccat ccatgaggca 3420 agggctggga acacagtgtc tttgcctatg gtagatccat gtgaatgtca ggaagccagc 3480 tcttcagtct tggagatgat ttctgctaca attctgtaga aagattaagg atggcagagt 3540 aaaaggttac caagaatgcc aggatgtttt tcttgggcgt aggaggtcca gattactttc 3600 ctttttgatg aaagagtttg gaagactgtc ccatctctct ggcttgagaa atctctgcca 3660 ttttaaacat cactgtgaaa tagcaattat tatcatctgt atttagtttt aacattaccc 3720 acaacataga aataataggt aaaaatcgtc ttgcctactc attccaaaga tgatcaagtc 3780 attaatctag caaagtattc atgtatcaga ttttgtatat tttgaatcaa agctaactag 3840 gaatgttaga tataagaatg taatgatatt catgcactga attctaagcc aatatgaaca 3900 aaaatgctgc atgaatggca catataggtc accaaagttc attcacaggt agaaaaaact 3960 tgtgctttct tttccatcta aaaacaaaag gagactttct ttatctcatt taaagaacag 4020 ctctttgaaa ttgaaattga ccctttttgc ttgaccttaa ggagattagc ttccagtaga 4080 tgagtttgca aaatactttt cctgttcttt tgttttgctg gtattgaaaa catcccacta 4140 aatcagatga agaggcatgg gaggaaaaat atccaaatta attactaaaa tcgagaagag 4200 aaggcaaact cttgaaaagt aaaaaggtgt ttgtgacctt cagtatttat tgaacagagg 4260 aaataactga caagggcaat acaattcaat gttcatgtag taacattcat gtcacttgtt 4320 gaatttggtt ctcatatgta tattgcatac acataaattc aaactataag tcgtcatttt 4380 tgagccatca tcttacattc atgtaatgaa attatggaag agagtaaaaa ctagctctta 4440 acttagtaaa tataatatgg tatttaaaat caggtcacta cagtaaggtt ctaagtattg 4500 ccaattgaaa agctagaaat ggtattactg ttgcaaagtg ttgtcaataa ttgactccaa 4560 tagcattgta aatacttgta tcccacaact attttaaacc caagcaataa aatggatttt 4620 ctaattcact tcaattcttt atttctctta cctatctatg tcttggtaca taagaaaagt 4680 gtttccatca ctgcattggt agaattattt cagtgttatt atttttgtga tttcgtatgt 4740 ctacacaaaa atgaattagt ttaatttata ttgtgataca gttgtttgag aaatattttt 4800 aattctgttt caactttatt tctccaagtg tataatataa aaattacttc tgttattgtt 4860 ctctaccaat aggggaaaaa attaaaacat tagatccatt gagaaagaga tgatgtaata 4920 aataattaag attagtaata atattatcag gggtgattat gaccagttga ataatctctt 4980 tcccttgaat tatttagcta acaaattaac tctcccaaat atttaaaata atgtaaaatc 5040 atattttact gcccattatt aactaaaata tttttgtttg actttgagca ccaactggta 5100 atactaataa atacccatgt catgcagatg gctgggcgaa taagagatgt ctaaaaatat 5160 gcactggtct tggaaaacat ggcacaagta aggatatcat atatgatgtc tgtttatttt 5220 atgtctgatt tcttttgaat gagtagttgg ggactccatt tctaaggaga ctaggtaaat 5280 aaaatgacct ttgacatttc a 5301 <210> 2 <211> 10053 <212> DNA <213> ITPR1 <400> 2 gcagtaacca tgtggatgtg ctgctgaagc gtttcctcaa gctcgctggg gtgggaggag 60 aggaggagga ggaggtggtg gtggaggagg aggcaggggg tggagagaga gaaagcgcac 120 gccgagagga ggtgtgggtg ttccgcttcc atcctaacgg aacgagctcc ctcttcgcgg 180 acatgggatt acccagcggc tgctaacccc tctcctcgcc ctgctccccc aaaccggcgt 240 ggctccccgg gcaccaagga gctgactaca gaggagcagg atttgcaccc ctcgctgggc 300 ttgctttggc aacagagtgc ctgacccagg tcaggatttt caagaaagac atgtctgaca 360 aaatgtctag cttcctacat attggagaca tttgttctct gtacgcggag ggatcgacaa 420 atggatttat tagcaccttg ggcctggttg atgatcgttg tgttgtacag ccagaaaccg 480 gggaccttaa caatccacct aagaaattca gagactgcct ctttaagcta tgtcccatga 540 accgctactc tgcccaaaag cagttctgga aagccgctaa gcctggggcc aacagcacca 600 cagacgcagt gctactcaac aaactgcacc acgctgcaga cttggaaaag aagcagaatg 660 agacagaaaa caggaaattg ctggggaccg taatccagta tggcaatgtg atccagctcc 720 tgcatttgaa aagtaataaa tacctaacag tgaataagag gcttcctgct ctgttggaga 780 agaatgccat gagagtcaca ttggacgagg ctggaaatga agggtcctgg ttttatattc 840 agccattcta caagctgcga tccattggag acagcgtggt cataggtgac aaggtggttc 900 tgaaccccgt caatgctggt cagcccctac atgctagcag ccatcaactg gtagataacc 960 caggctgcaa tgaggtcaat tccgtcaact gcaatacaag ctggaaaata gtccttttca 1020 tgaaatggag tgataacaaa gacgacatat taaagggggg tgacgtggtg aggctgtttc 1080 atgctgagca ggagaagttt ctcacctgtg acgaacacag gaagaagcag cacgtcttcc 1140 tgagaaccac gggccggcag tcggccacat ctgccaccag ttcaaaagcc ctgtgggagg 1200 tggaggtggt ccagcatgac ccatgtcggg gcggagcagg gtattggaac agccttttcc 1260 gtttcaagca tctggccacg gggcattact tggcagcaga ggtggaccct gatcaggacg 1320 cctctcgaag taggttgcgg aatgcccaag aaaagatggt atactccctg gtctctgtgc 1380 ctgaaggcaa tgacatctcc tccattttcg agctagatcc caccactctg cgtggaggtg 1440 acagccttgt cccaaggaac tcttatgttc ggctcagaca cctatgtact aatacctggg 1500 ttcacagcac aaatattcct attgacaagg aagaagaaaa gcccgtgatg ctgaaaattg 1560 gcacctctcc tgtgaaggag gataaggaag catttgccat agttccggtt tctcctgctg 1620 aagttcggga cctggacttt gccaatgatg ccagcaaggt gctgggctcc attgctggga 1680 agctagagaa gggcaccatc acccagaatg aaaggaggtc tgtaaccaag ctgctagaag 1740 atttggttta cttcgtcact ggtggaacta attctggtca agatgttctc gaagttgtct 1800 tctccaagcc caacagagaa cggcagaaac tgatgagaga acagaatatt ctcaagcaga 1860 tcttcaagtt gttacaagcc ccattcacag actgcggtga tggcccaatg cttcggctgg 1920 aagagctcgg ggaccagcgg cacgctcctt tcagacacat ctgccggctc tgctacaggg 1980 tgctgagaca ctcgcagcaa gactacagga agaaccagga gtatatagcc aagcagtttg 2040 gcttcatgca gaagcagatt ggctatgatg tgttggctga agacactatc actgccctgc 2100 tccacaataa tcggaaactc ctggaaaaac acataccgc ggcagagatt gacacatttg 2160 tcagcctggt gcgaaagaac agggagccca gattcttaga ttacctctcc gacctctgtg 2220 tctccatgaa caaatcaatt ccagtgaccc aggaactgat atgtaaagct gtgctgaacc 2280 ccaccaacgc tgacatcctg attgagacca agttggttct ttctcgtttt gaatttgaag 2340 gtgtctcttc cactggagag aatgctctgg aggcaggaga agacgaggaa gaggtgtggc 2400 tgttttggag ggacagcaac aaagagattc gcagcaagag tgtgagggaa ttggctcagg 2460 atgctaaaga agggcagaag gaggaccgag acgttctcag ctactacaga tatcagctga 2520 acctctttgc gaggatgtgt ctggaccgcc aatacctggc catcaacgaa atctcaggcc 2580 agctggatgt cgatctcatt ctccgctgca tgtctgacga gaacctgccc tatgacctca 2640 gggcgtcctt ctgccgcctc atgcttcaca tgcatgtgga ccgagatccc caggaacaag 2700 tcacccccgt gaaatatgcc cgcctctggt cggagattcc ctcggagatc gccattgacg 2760 actatgatag tagtggagct tccaaagatg aaattaagga gagatttgct cagaccatgg 2820 agtttgtgga ggagtattta agagatgtgg tttgtcagag gttccctttc tctgataaag 2880 agaagaataa gcttacgttt gaggttgtaa atttagctag gaatctcata tactttggtt 2940 tctacaactt ctctgacctt ctacgattaa ctaagatcct tctggccata ttggactgtg 3000 tacatgtgac aacaatcttc cccattagca agatggcgaa aggagaagag aataaaggca 3060 gtaacgtgat gagatctatt catggcgtgg gagagctgat gacccaggtg gtgctccggg 3120 gaggaggctt tttgcccatg actcccatgg ctgctgcccc tgaaggcaat gtgaagcagg 3180 cagagcctga gaaggaggac atcatggtca tggacaccaa gctgaagatc attgagatac 3240 tccagtttat tttgaatgtg aggttggatt ataggatctc ctgcctcctg tgtatattta 3300 agcgagagtt tgatgaaagc aattcccaga cttcagaaac atcctccgga aacagcagcc 3360 aagaagggcc aagtaatgta ccaggtgctc ttgactttga acacattgaa gaacaagcag 3420 aaggcatctt tggaggaagt gaggagaaca ccccactgga cttggatgac cacggcggca 3480 gaacctttct ccgtgtcctg ctccacttga cgatgcatga ctacccaccc ctggtgtcag 3540 gggccctgca gctcctcttc cggcacttca gccagaggca gggaggtgctc caggccttca 3600 aacaggttca actgctggtt accagccaag atgtggacaa ctacaaacag atcaaacaag 3660 acttggatca actgaggtcc atcgtggaaa agtcagagct ttgggtgtac aaagggcagg 3720 gccccgatga gactatggat ggtgcatctg gagaaaatga acataagaaa acggaggagg 3780 gaaataacaa gccacaaaag catgaaagca ccagcagcta caactacaga gtggtcaaag 3840 agattttgat tcggcttagc aaactctgtg ttcaagagag tgcctcagtg agaaagagca 3900 ggaagcagca acagcgtctg ctccggaaca tgggcgcgca cgccgtggtg ctggagctgc 3960 tgcagattcc ctatgagaag gccgaagata ccaagatgca agagataatg aggttggctc 4020 atgaattttt gcagaatttc tgcgcaggca accagcagaa tcaagctttg ctacataaac 4080 acataaacct gtttctcaac ccagggatcc tggaggcagt aaccatgcag cacatcttca 4140 tgaacaattt ccagctttgc agtgagatca acgagagagt tgttcagcac ttcgttcact 4200 gcatagagac tcacggtcgg aatgtccagt atataaagtt cttacagaca attgtcaagg 4260 cagaagggaa atttattaaa aaatgccaag acatggttat ggccgagctg gtcaattcgg 4320 gagaggatgt cctcgtgttc tacaacgaca gagcctcttt ccagactctg atccagatga 4380 tgcggtcaga acgggatcgg atggatgaga acagccctct catgtaccac atccacttgg 4440 tcgagctcct ggctgtgtgc acggagggta agaatgtcta cacagagatc aagtgcaact 4500 ccctgctccc gctggatgac atcgttcgcg tggtgaccca cgaggactgc atccctgagg 4560 ttaaaattgc atacattaac ttcctgaatc actgctatgt ggatacagag gtggaaatga 4620 aggagattta taccagcaat cacatgtgga aattgtttga gaatttcctt gtagacatct 4680 gcagggcctg taacaacact agtgacagga aacatgcaga ctcgattttg gagaagtatg 4740 tcaccgaaat cgtcatgagt attgttacta ctttcttcag ctctcccttc tcagaccaga 4800 gtacgacttt gcagactcgc cagcctgtct ttgtgcaact gctgcaaggc gtgttcaggg 4860 tttaccactg caactggtta atgccaagcc aaaaagcctc cgtggagagc tgtattcggg 4920 tgctgtctga tgtagccaag agccgggcca ttgccattcc cgtggacctg gacagccaag 4980 tcaacaacct ctttctcaag tcccacagca ttgtgcagaa aacagccatg aactggcggc 5040 tctcagcccg caatgccgca cgcagggact ctgttctggc agcttccaga gactaccgga 5100 atatcattga gagattgcag gacatcgtct ccgcgctgga ggaccgtctc aggcccctgg 5160 tgcaggcaga gttatctgtg ctcgtggatg ttctccacag acccgagctg cttttcccag 5220 agaacacaga cgccagaagg aaatgtgaaa gtggcggttt catttgcaag ttaataaagc 5280 atacaaaaca gctgctagaa gaaaatgaag agaagctctg cattaaggtc ctacagaccc 5340 tgagggaaat gatgaccaaa gatagaggct atggagaaaa gggtgaggcg ctcaggcaag 5400 ttctggtcaa ccgttactat ggaaacgtca gaccttcggg acgaagagag agccttacca 5460 gctttggcaa tggcccactg tcagcaggag gacccggcaa gcccggggga ggagggggag 5520 gttccggatc cagctctatg agcaggggtg agatgagtct ggccgaggtt cagtgtcacc 5580 ttgacaagga gggggcttcc aatctagtta tcgacctcat catgaacgca tccagtgacc 5640 gagtgttcca tgaaagcatt ctcctggcca ttgcccttct ggaaggaggc aacaccacca 5700 tccagcactc ctttttctgt cgcttgacag aagataagaa gtcagagaaa ttctttaagg 5760 tgttttatga ccggatgaag gtggcccagc aagaaatcaa agcaacagtg acagtgaaca 5820 ccagtgactt gggaaataaa aagaaagacg atgaggtaga cagggatgcc ccatcacgga 5880 aaaaagctaa agagcccaca acacagataa cagaagaggt ccgggatcag ctcctggagg 5940 cctccgctgc caccaggaaa gccttcacca ctttcaggag ggaggctgat cccgacgacc 6000 actaccagcc tggagagggc acccaggcca ctgccgacaa ggccaaggac gacctggaga 6060 tgagcgcggt catcaccatc atgcagccca tcctccgctt ccttcagctc ctgtgtgaaa 6120 accacaaccg agacctgcag aacttcctcc gttgccaaaa taacaagacc aactacaatt 6180 tggtatgtga gaccctgcag tttctggact gtatttgtgg aagcacaact ggaggccttg 6240 gtcttctggg cttgtatata aatgaaaaga atgtagcgct tatcaaccaa accctggaaa 6300 gtctgaccga atactgtcaa ggaccttgcc atgagaacca gaactgcata gccacccatg 6360 aatccaatgg cattgacatc atcacagccc tgatcctcaa tgatatcaat cctttgggaa 6420 agaagaggat ggaccttgtg ttagaactga agaacaatgc ctcgaagttg ctcctggcca 6480 tcatggaaag caggcacgac agtgaaaacg cagagaggat actttataac atgaggccca 6540 aggaactggt ggaagtgatc aagaaagcct acatgcaagg tgaagtggaa tttgaggatg 6600 gagaaaacgg tgaggatggg gcggcgtccc ccaggaacgt ggggcacaac atctacatat 6660 tagcccatca gttggctcgg cataacaaag aacttcagag catgctgaaa cctggtggcc 6720 aagtggacgg agatgaagcc ctggagtttt atgccaagca cacggcgcag atagagattg 6780 tcagattaga ccgaacaatg gaacagatag tctttcccgt gcccagcata tgtgaattcc 6840 taaccaagga gtcaaaacta cgaatttact atactacaga gagagacgaa caaggcagca 6900 aaatcaatga tttctttctg cggtctgaag acctcttcaa tgaaatgaat tggcagaaga 6960 aactgagagc ccagcccgtg ttgtactggt gtgcccgcaa catgtctttc tggagcagca 7020 tttcgtttaa cctggccgtc ctgatgaacc tgctggtggc gtttttctac ccgtttaagg 7080 gagtccgagg aggaaccctg gagccccact ggtcgggact cctgtggaca gccatgctca 7140 tctctctggc catcgtcatt gccctcccca agccccatgg catccgggcc ttaattgcct 7200 ccacaattct acgactgata ttttcagtcg ggttacaacc cacgttgttt cttctgggcg 7260 ctttcaatgt atgcaataaa atcatctttc taatgagctt tgtgggcaac tgtgggacat 7320 tcacaagagg ctaccgagcc atggttctgg atgttgagtt cctctatcat ttgttgtatc 7380 tggtgatctg tgccatgggg ctctttgtcc atgaattctt ctacagtctg ctgctttttg 7440 atttagtgta cagagaagag actttgctta atgtcattaa aagtgtcact cgcaatggac 7500 ggtccatcat cctgacagca gttctggctc tgatcctcgt ttacctgttc tcaatagtgg 7560 gctatctttt cttcaaggat gactttatct tggaagtaga taggctgccc aatgaaacag 7620 ctgttccaga aaccggcgag agtttggcaa gcgagttcct gttctccgat gtgtgtaggg 7680 tggagagtgg ggagaactgc tcctctcctg cacccagaga agagctggtc cctgcagaag 7740 agacggaaca ggataaagag cacacatgtg agacgctgct gatgtgcatt gtcactgtgc 7800 tgagtcacgg gctgcggagc gggggtggag taggagatgt actcaggaag ccgtccaaag 7860 aggaacccct gtttgctgct agagttattt atgacctctt gttcttcttc atggtcatca 7920 tcattgttct taacctgatt tttggggtta tcattgacac ttttgctgac ctgaggagtg 7980 agaagcagaa gaaggaagag atcttgaaga ccacgtgctt tatctgtggc ttggaaagag 8040 acaagtttga caacaagact gtcacctttg aagagcacat caaggaagaa cacaacatgt 8100 ggcactatct gtgcttcatc gtcctggtga aagtaaagga ctccaccgaa tatactgggc 8160 ctgagagtta cgtggcagaa atgatcaagg aaagaaacct tgactggttc cccaggatga 8220 gagccatgtc attggtcagc agtgattctg aaggagaaca gaatgagctg agaaacctgc 8280 aggagaagct ggagtccacc atgaaacttg tcacgaacct ttctggccag ctgtcggaat 8340 taaaggatca gatgacagaa caaaggaagc agaaacaaag aattggtctt ctaggacatc 8400 ctcctcacat gaatgtcaac ccacaacaac cagcataagc aaatgaaaga aaggaattgt 8460 atttaccttt tataattatt attagtgtgg gtatggctaa tgagttctga ttcacccacg 8520 aaggttacat ttatgctgaa tacatttgta aatactcagt tttatactgt atgtatatga 8580 ttgctactct aaaggtttgg atatatgtat tgtaattaga attgttggca tgatgacatt 8640 tcatttgtgc caaaaatatt aaaaatgcct tttttggaag gactaacaga aagcacctga 8700 tttgcacttg aaccagatta tagatttaaa agtatatgac atgtattttg tatttaaaac 8760 tagaatagcc agtatttatg ttttttataa aactgtgcaa tacgaattat gcaatcacaa 8820 tacatttgta gctcccgagt gtcctaaagg gagtgcactt ctttgaagct ggtgtgttaa 8880 tactatgtaa taaatggtta actttcaaat gatgctgctg ccaaaattat attaatagtg 8940 agtttcaggc ccctgggcat tttgtaccat gtaattatcc tctggtgatg ctgtttctcg 9000 ttagtggcag tagtgcctcc gtctcctagt gataatgctc caagtctatg aactgttaaa 9060 tcagcattca ttttaagaaa agcaacttta gtttcaaaga tacttttaag cttctaaatt 9120 gatcatttaa actatttctt taaataagag agccaaatta gaggctcata ctttagcttg 9180 tgaagaagat aatgaatttt ttaaagggaa ctttctatgc aatgttcagg ataaatgcat 9240 actgctggcc aatcagtgtc atctcctggg taaattttga tgtcgcatta taaagacatg 9300 cataattgat ggtttctaga ttatctagtc caaacaatag agtttatttt ttcttcatct 9360 gaaccaacat gctacagtag ctaagaagta ttaaaactat atacatccat ataaagatga 9420 aatatgaact atctcattag aagtcatagt tgaccacaga catgttattc ttctgaaaga 9480 gccacatttt ggttttattt cttgtcacat gatttctttt cttgatggat gaaaaatatg 9540 aaaggaaact tttatatctg ttgcctagtt ttgtacatgg atctcatttt acaagagaat 9600 ctctctgcaa aaaaaaaaaa aacagtttaa aaatgcattg aaagcagagt tctgaaatga 9660 gtaaagtttg taaatgcata tataaaaata tttaataaat gatgcagaat atacagtgac 9720 tggttggtgg ctttcatttg gcatttgtga cttaactgct attccattta tgtactttct 9780 ttaggatcag tttgaagtac agtcggtttg attaccaggt taattcagaa aatgtttacc 9840 tgattattta aaaaaacact tgctgttgtt atgacagctc tgaggagaat tattagaaca 9900 aacattgggg agtatttagt acaacattca ttcattcttc tggattagtg actgccagcc 9960 aggctgtcgg gagcgcccta ctaaatctcc tgtctcttct gcttttactg ggggatcttt 10020 aatttgctgt gtgccatgtg gaagtatcgg gaa 10053 <210> 3 <211> 6853 <212> DNA <213> SHISAL1 <400> 3 acactgaatt cttgtcagca cacagaggcc agcctgcgct ggaaaacact cttttgccta 60 tacaaggctc gaccaagttg ctctcctttt attggggttt aaggttggtg gcaaccagga 120 gccggggaag aggccagcag ctgcagggag accgcagcca gcggaggggg cttctgatcc 180 ctcagtcaca gggctcggca ggcagctctg gacggatcaa tgcaagccag acgatgacca 240 gttgtggcca gcagtccttg aacgtgctcg ccgtcctctt ctcattgctg ttttctgcag 300 tcttgtctgc acatttccgg gtctgtgaac catacacaga ccacaaaggc cgctaccact 360 ttggcttcca ctgcccccgg ctctcggaca acaagacctt catcctctgt tgtcaccata 420 acaacacggt cttcaaatac tgctgcaacg agacggagtt ccaggcggtg atgcaggcga 480 acctcacggc cagctccgag ggttacatgc acaacaatta caccgccttg ttgggagtgt 540 ggatctatgg atttttcgtg ttgatgctgc tggttctgga ccttttgtat tactcggcaa 600 tgaactacga catctgcaag gtctacctgg cacggtgggg catccaagga cgatggatga 660 aacaggaccc ccggcggtgg gggaaccccg ctcgggcccc tcggccgggt cagcgggccc 720 cacagccgca gcctccccca ggcccgctgc cacaagcccc acaggccgtg cacacattgc 780 ggggagatgc tcacagccca ccgctgatga ccttccagag ttcgtctgcc tgaaaacgct 840 tttgctgtgc ctcaggatgg gggagatgag atctgaagca cccggtgcag cctccgagaa 900 gaacaacttc tacagagatg ccagggacag ccgaggtagc ggcggtggca caggaggaaa 960 tgctgcctgt gcccaaagcc cccttccgcg gacttctaag attaggagca aactcagggg 1020 taggggctgg gggtgcaggg gaggggattc tgagccacct gtccgcaagc aatagtccta 1080 ttttgggctg gtggcttctg agaggtgact cattgtggac tcaggatgac caagacaaag 1140 caactctggc tgattccagc caggaggatt gaggcctgtg agttatacct gtggttgaaa 1200 accgaagctt cccttgcccc tgctccctcc agtagtggcc ccttggggct atttgtgtca 1260 gaatattgaa tgtgcgtgtg tgtgtgcgtg tgtgtgattt ggggtgttct ttttgttttgc 1320 ttggttggtt ggtttttatt ggggcttccc ccctcaagtt ctctgatggg catgagtcac 1380 cctccggctg ggggttctca tccgtgtcaa tgtccgagcc gcaagcttat tgctaagcac 1440 agggtacggc ccctctgtgt ctcggggagc actggggatt tgaaaatgcc agtcagggtt 1500 gtttcttaca gaattcgttc ctgtaacaat agtaatacta agggctgcat ctcaggctga 1560 ccacagggca ggtgccaagt taagtgtttt catgcactcc ctctctcacc acctgggagg 1620 caggtatgat taaccccctg cagaaaaact cacagtgggg aagcggtgcc ggaacccaaa 1680 gtccaggctc caactccctg gacgtgacat gctcgccagc cggggtacac cctgcacaat 1740 gctgggagca tctccttgat gcctccacca tcaccgcctg gagcgctgat ccactcagca 1800 cattctggct aagcatctgc tgtgtgccag gccccgtgct gggcagtgat gggaatgaaa 1860 gatgagttag atctcatctc tgccccccggg gagcctccca tctggtggga gacacagaca 1920 cgtggatctt tgctggaaag ggtaacaagg ccatggaaac ccaggcagga gcgttctaga 1980 aatccatcca ctttcaagta ggacttccat gcccgtaaca tccacccacc gagctaatca 2040 cccccactcc tgccccgctg ccctgggaca cctatgagat ggcatcacct aaatcatcac 2100 aaacatctcc aaaggccatg ctgccagtgt agacacactc attccatggg tgttagtgat 2160 accaaatctc ccccagctct tagctcggga ggccctgctt gatcaatgtg tgtgtcctct 2220 gacgcagttt cctcatttca tcagacctag tgttctcaca ctgaccaccc atccattcac 2280 cagacacgac agtgagcaag gcaggtccct gctcactgtg ctagctttct agctggggca 2340 ggaagacagt gaagaaggaa ggtggcgaag gcagtgagtg ctctgccggg aactcagtgc 2400 caggaactca gttcgaggga cacgtgagtg agacccttgt ggacctgggg tggtctggga 2460 aggccgcctt gagcagatga ttgaagccca gatttgaatg acacacagga gccagtaatg 2520 ggcgttaaag ataggaaaag agcattccag gcagaaggaa cggctagtgc aaagatcctg 2580 cggcagccac aggcttggtg gtttcaagga agcacaagaa agccaggtgg cacaagaaag 2640 ccaggtggct ggggacccag agggaaggca gaaggagatg agggtgatag tgcccagctc 2700 tgggctctgc tgtgagtcaa gctgtgcaaa cacaatgtcc tgcctttgga aaagcagaac 2760 aaacttgcta gggtataaag catcctccat tctgcctggc tgtccatcct ctcaacagcc 2820 ccatgaagaa ggggctctcc ccattttatg gacaagaaga cagactcagc tgggtcaagt 2880 ggcttgccca ggatcacaca ggtcagctgt ggaagaccca ggcccctggc ttcagtcttt 2940 gggtccagct gtctcctcca ggcagtgctg ccagtgtcca ggcatatggc ttggcaaagt 3000 gggagaacct ctgcttgggg tctcgattgg agaaaggaat ggcttcctct cccctgatgt 3060 gagccgtccc agggccatgt tgccgtaagg gggtgcacag cctgtccact agcccagctg 3120 cggaagccac agctgtgtcc cacgtgcagt gcctcagaag gcagaggaag ccttgaggtg 3180 ggggcccaag acccagattc tgacatcagc tctgccactg agaacagcgt gacctcaggc 3240 aaggtctgtt acctcagttt ccccatcggt aagaggaagg agtcagatgg gtatttaagg 3300 agtttgcaac cctcgtgtcc tgctgtcctg gacaatgctc tgtaggtgct tcctctgcca 3360 aaaaggaact ggtggccttg cctccctctc ctggacacct ggggtcaaag gtcactgcca 3420 aataagacagc tagaactggg gttcacctaa gcatcccttg agatgtacaa ccttctagga 3480 ggacattcct cctgcctgcc cccctccccg caagaggtct tttcaggaat aactgaaaaa 3540 cccatggggt ttgtggtcct gctgctctgc caagtccctc ttgggcagct gggctgagga 3600 ctggaacatt ctgtggcaag caggaggcct cagcagagat caccaagacc cagcacacct 3660 ggtgcagaca gccacggcat cctccttcct gcaggtcacc cccacgagcc acttaacctc 3720 tcagagcctc tgcttctcac ctgtcaagtg tgtgaggtag ggtaccagtt agtcacggta 3780 cttgctgtct cacagaggag ccgacaggtg agaacagtgt gcatgtgggt gtgaacactc 3840 agtgtggaaa gcaggtgtgt gtgtattcaa tcccccaatg gtgtcaaggg ctcctcaaaa 3900 tgccatgggt ccccaggtca ttgtgataaa cactgtcccc atcctgctgt ggttgtggct 3960 ggaaggtccc tcaaggagta gactgtccct gagaacaaga tggatgcagg gtagtgacga 4020 gttcaagcat agctagagtt actgtttttt agcaactcaa cctgattttt taagctgcct 4080 acttttactt tttactgtga gcttctgtcc atcaccatgt aatttgtaat aataataata 4140 caaaaagaaa aacgagagag agaagaggac aagatgtcca cagaggaatc tgcattcgag 4200 gctgtttgca gaactaccgc gtttgtaagg actgtttccc actgggaact gtgtgtaatt 4260 aatgagcagt tttatgcttt ccctctcgtc tgtgtacggt gtgattgttg tgtgtttcag 4320 aatctctatt cagaaccaat agctggtaat gcctgctggc tcgctgccct caagttagcc 4380 tctgaacgtg ccctgcacct agagaagcag ccttctcacc cgcctcacct ggctgctcca 4440 gcggccaggc cagccacctg accatgacca ttgctgatgt gcaacaggcc ttaattgaaa 4500 aaacacacaa gtacatacat gcacatgcgc gcacacacac aggtgatttc acaggtagat 4560 ctggtccctc ttgctgtctc caatgctcta gaaagcagca agtaggcagc tgacagtgtt 4620 cccagggtga gtggcatctc ccctcatcat cagaaagatt cagtcaaatt ttggcccaga 4680 gctgaagagg aggacttggg aatgtcaggg aaaacatgac agggctaggg gttaacaggc 4740 ttctttggcc aggagatggt ttccagttca ccgtcaaccc aaaagctctc ttcaggtcat 4800 ggcaaacaga ccagggctgt gggtgtggct gtgcttggca ctgactcccc cacaggccgc 4860 tgtccaggtt ggctcaggat tccagctgcc atccccaggc aggcccctcc gctggctcgg 4920 ctgctttcac aatcaccatg tctgtctatt agagactgtg ccattcaagg aacggggtc 4980 cccgggggtg cagacttgta aaatttttta atttttcaac ttggctgaac tggtccccat 5040 caacaggaaa agccttcgga agtgaattta cagatttctc ccatgtttga aattaacata 5100 acatgaaccc agaaggcaga gcttgcagtg agctgagatc gcaccagtgc actccagcct 5160 gggcaacaga gtgagactct gtctaggtag gtaggtaaga aggaaggaag gaagaacaga 5220 cctggatgga gttattggga acatgtctta tcaatgttga agggccccct atcactgtag 5280 ggagacatcc acgtgggttg ttttcgtctg ctgtgaaaat ctagggttgg aatcatggaa 5340 gcaaactgca ggaattctta atcatcctgc tcacgtggtg ggcatcagag ggtgtctgct 5400 tggcccccac agcactggga cagtcagaga ggccatgagt ggatgacgcc ctgatcactg 5460 ccctttgcag tccaggaata cctcactggg ctggggccat accctgtgcc ctctggaaga 5520 caagcctgcg cacttactat gtgccagatg ccatgcacag tgccctagtt ccttgctgta 5580 gcaccaacac gtcccacgct ggtgcttaaa tgcacgcaaa caactttggt ggttgtggcc 5640 cgaaaagctc aaatgttaaa gttaagcagt caggcaagct agaagaggtg aggagcctcc 5700 tagaaaactc attcgatgac acgcgcttcc ctcacctatt cagatacttg ccgagtgcct 5760 gccacttgcc tggccctgta cccagggccc atctgggagc cattcctgct atagctggga 5820 ccacttgtga aacggctagt tgtgcctaac agacatgctc agattcacaa aatgaattca 5880 gaacacttac ctgtcccacc cgtgaaagtg accttggagg tgtcattgcc ccccaccacc 5940 ccagtttcta gtccaagcca acagctggtg ctagatagat gcttgatgaa tgagcagatt 6000 tgactgttag ttactctgta cctaaaactc ctatctttac atcaaagccc tgacagattt 6060 gcccttgaca gactgaaatc cggggctgct gcagggttca cctccaggag gcaccattca 6120 cgacactgtc ccataaatgg taatgggctc ccagggatac tgtttacata gactgcactg 6180 agaacggtga cccttaggtt tgtacaatga ggtaccctgt tgaatgaccc taaaccagcc 6240 tccaaaatgt gcaggatccc acattggtca gcgccaaccc tgagcacagg atctaaaact 6300 atagatgata tggccaccct ggccacagct ggaaccaagc tggtggccca agagagagcc 6360 tcttcttgga attgcatgtc agtttctcat acgcagtttc ttcctatttt tcccatttcc 6420 cgttttaaag ctagtggcat acctcacagt caaataacca agtggtcagt gtctcgacaa 6480 tgtgcagtaa cgaggtgggg gctgcaaggg tgaggggctc agtcacctta acaaggcagg 6540 agacctccca caaaaggctg atgtgtcgtc cccagggcca gctggacaag ggcatgcagc 6600 gcaggggtag ggggatggaa atattttctc tcccgtaaac tctgacttca tgtgagcagg 6660 catggggtct ccctgagagc tgataaccgg gaaaaccaaa accaataata ttcctaataa 6720 taatactaga atgtaagaat aatcatgtgt ttttcactga ccgctgttgc tctgcttttg 6780 tctttatata cagtagtttt tataacaatg tccctaggtt ttaataaagg agtgtcatgt 6840 caactgttcc cta 6853 <210> 4 <211> 5043 <212> DNA <213> ABCC10 <400> 4 agcatatggg cgtggcgaat agcgccggct aggtcttcca acctctaggt ggggtgccag 60 ccggggcggg cccagcaccc cggccgggca gtactttttt tttttttgca tacaccagtt 120 ctcaggatat cggaatccgg tgcacagcag cttcttcagg tttgaggttc cggatgcctg 180 ggggcggaga aacgggaggg gaaaaacaga tggcaaggtg aggcgtccat ggaacgactt 240 ctggcccagc tgtgcggcag cagcgcagcg tggccgctcc cgctgtggga gggggacacc 300 acaggccact gcttcaccca gctggtgctc agcgccctgc cccacgcgct cctcgccgtg 360 ctcagtgcct gttacttggg caccccgagg agtccagatt acatcctacc ctgcagtcct 420 ggatggcgcc tccgacttgc agcttccttc ctgctttccg tcttcccgct gctagacctt 480 cttccagttg ctttgccacc aggggcaggc ccaggaccca tagggctaga ggtgttggca 540 gggtgcgtgg cagctgtggc ctggatcagc cacagcctgg ccctgtgggt gttggcacat 600 tcccctcatg gccactcccg gggtcccttg gccttggccc tggtagcctt gctgccagct 660 ccagccctag tgctgaccgt gttgtggcat tgccagcgag gcacacttct gccccccactt 720 ctcccagggc ccatggcccg cctatgcttg ctcatcctgc agctggctgc actcttggcc 780 tatgcactgg gatgggcagc tcctggggga ccacgagaac cctgggctca ggagcccctc 840 ctgcccgagg atcaagaacc tgaggtggct gaagatgggg agagttggct gtcacgcttt 900 tcctatgcct ggctggcacc cttgctggcc cgtggggcct gtggagagct ccggcagcct 960 caggacattt gccgcctccc ccacagactg cagccaacct acctggctcg tgtcttccag 1020 gcacactggc aggagggggc acggctgtgg agggccttgt atggggcctt tggacggtgc 1080 tatctggcac ttggactgct gaagctggtg gggaccatgt tgggattctc agggcccctg 1140 ttgctctccc tactggtggg cttcctggaa gaggggcagg agccactaag ccacggcctg 1200 ctctatgctc tggggctagc cggtggggct gtgctgggtg ctgtgctgca gaatcagtat 1260 gggtatgagg tatataaggt aacacttcag gcacgggggg ctgtgctgaa catcctgtac 1320 tgcaaggctt tacagctggg gcccagccgc cctcctactg gggaggccct gaacctacta 1380 ggcactgact ctgaacggct gcttaacttt gctgggagct tccatgaagc ctggggcctg 1440 cccctgcaac tggccatcac cctctacctg ctgtaccagc aggtaggcgt ggccttcgtg 1500 ggtggtctca tcttggcact gctgctggta cccgtcaaca aagtgattgc cacccgcatc 1560 atggccagca accaggaaat gctacagcac aaggatgcgc gggttaagct tgtgacagag 1620 ctgctgagtg gcattcgggt catcaagttc tgcgggtggg agcaggcact gggagcccga 1680 gtagaggcct gccgggctcg agagctgggg cgactccggg tcatcaaata cctggatgcg 1740 gcctgtgtat acctgtgggc tgccctaccg gttgtcatct ccatcgttat cttcatcacc 1800 tatgtcctca tggggcacca gctcactgcc accaaggtgt tcacggccct ggcactggtg 1860 cgaatgctca ttcttcctct caacaacttc ccttgggtga tcaatggtct cctggaggcc 1920 aaagtgtcct tggaccggat ccagcttttc ctcgaccttc caaaccacaa cccccaggcc 1980 tactacagcc cagatccccc tgcagagcca tctacagtat tggagctgca tggagccttg 2040 ttctcctggg acccagttgg aaccagcctg gagaccttca tcagtcatct cgaagtgaaa 2100 aagggtatgc tggtgggcat cgtggggaag gtcggctgtg ggaagagctc cctgctggct 2160 gccatcgctg gagagctcca caggctgcgt gggcatgtgg cagtgcgggg gctgtccaag 2220 ggctttggcc tggccaccca ggaaccctgg atccagtttg ccaccatccg agacaacatc 2280 ctctttggga agacatttga tgcacagctg tacaaggagg tgctagaagc ctgcgccctc 2340 aatgatgacc tcagtatcct gcctgctgga gaccagacag aggtggggga gaagggtgtc 2400 acccttagcg gaggacagcg tgcccggatt gcccttgctc gtgctgtcta ccaggaaaag 2460 gagctctatc tcctcgatga ccctctggcc gctgtggatg cagatgtggc caaccacctg 2520 ctgcacaggt gcatcctggg catgctgagc tacaccacac ggctgctctg cacccaccgc 2580 actgagtacc tggagagggc tgacgcggtg ctgctgatgg aggccgggcg cctcatccgg 2640 gctggacctc cctctgagat tctgccactg gtacaagctg tccccaaagc ctgggctgag 2700 aatggacaag agtctgactc agccacagcc cagtcagtac agaacccaga gaaaacaaag 2760 gaggggctgg aggaggagca gagcacatct ggtcgcctgc tgcaggaaga aagcaagaag 2820 gagggcgccg tggccttgca cgtgtaccaa gcttactgga aggccgtggg ccagggcttg 2880 gccttagcca tcctcttctc tctgcttctc atgcaagcca cgcggaacgc tgctgactgg 2940 tggctctccc actggatctc tcagctgaag gctgagaata gctcccagga ggcgcaaccc 3000 tccaccagcc cagcttctat ggggctcttc tctccgcagc tgctcctctt ttcccctgga 3060 aacctctaca tcccagtgtt cccactgccc aaagctgccc ccaatggctc ctcagacatc 3120 cgtttctacc tcaccgtgta tgcgaccatt gctggtgtaa attccctctg cacccttctc 3180 cgggcagtgc tctttgcagc aggcaccctt caagcagctg ccactctgca tcgccgcctg 3240 ctgcatcgag tccttatggc accagtgact ttcttcaatg ccacacccac gggccggatc 3300 ctaaaccgct tctcctctga tgtggcctgt gcggatgaca gcctgccctt catcctcaac 3360 atcctcctgg ccaacgcggc aggcctgctg gggctcctgg ccgtgctggg ctctggcctg 3420 ccctggctgc tgctcctgct gccgcctttg agcatcatgt actatcacgt gcagcgccac 3480 tacagggcct cctcacggga gctgcggcgc ctgggcagcc tcaccctgtc tccactgtat 3540 agccatctgg ccgatacctt ggctggcctc tctgtgctcc gggccacagg ggccacctac 3600 aggtttgagg aggagaacct gcgactcctt gagctaaacc agaggtgcca gtttgccacc 3660 agtgccacaa tgcagtggct ggacattcgg ctacagctca tgggggcggc agtggtcagc 3720 gctatcgcag gcatcgctct ggtgcagcac cagcagggcc tcgctaaccc agggctggtg 3780 ggcttgtcgc tgtcttatgc cctgtccctg acgggcctgc tctcgggcct ggtgagcagc 3840 ttcacacaga cagaggccat gctggtgagc gtcgagcggc tggaagagta cacctgtgac 3900 ctgccccagg aaccccaggg ccagccactg cagctgggca ccggctggct gacccagggg 3960 ggcgtggagt tccaggacgt ggtgttggcg taccggccag ggctgccgaa tgccctggat 4020 ggagtgacct tctgcgtgca gcctggagag aagttgggca tcgtgggccg cacaggctcc 4080 ggcaagtctt ccctgttgtt ggtgctcttc cggctgctag agcccagttc agggcgagtg 4140 ctgctggacg gcgtggacac cagccagctg gagctggccc agctcagatc ccagttggct 4200 atcatccccc aggagccctt tttgttcagt gggactgttc gggaaaacct ggacccccag 4260 ggcctacata aggacaggggc cttgtggcag gccctgaagc agtgccacct gagtgaggtg 4320 attacatcca tgggtggtct ggatggtgag ctgggtgagg ggggccggag cttatctctt 4380 gggcagaggc agctgttgtg tttggccagg gctctcctca cagatgccaa gatcctgtgt 4440 atcgatgagg ccacagcaag tgtggaccag aagacagacc agctgctcca gcagaccatc 4500 tgcaaacgct ttgccaacaa gacagtgctg accattgccc ataggctcaa cacgatcctg 4560 aactcagacc gggtgctggt gctacaagcg gggagagtgg tagagctgga ctccccggcc 4620 accctgcgca accagcccca ctccctgttc cagcagctgc tgcagagcag ccagcaggga 4680 gtccctgcct cactcggagg tccctgagcc caatcccaca ccctgcagag ttctcccctc 4740 tctctgatcc aggccgggcc tatacagagg tgctggctgc ttgtttacat tctcctctgg 4800 ggctctacct ctccacactt ccccagaagg gaaaagggca ccctggatta ctctttggaa 4860 atcactcctt ggtgggcagc atcctgaggc ttccccagaa ccaggcctct gctctggccc 4920 tcttgcatct ggaacgccag gtgggttttt ctggcatagg agcccacttg cattttcata 4980 gttttatttg ataaaattcc atcttacatt ctgtgtatta aaaaaataat atttctggtg 5040 tga 5043 <210> 5 <211> 1854 <212> DNA <213> ACTL6A <400> 5 aagtgtggct gagctccggg gtgtgtggac gccgctttgt tgcctgaggt gggtggcggt 60 ggaagttaag ggagtcaggg gctatcgctc ctcgagactc gcagtcgcgg ccactgcagt 120 cacttcgcca gttagccctt agggtaggag tcgcgccggc agcagccatg agcggcggcg 180 tgtacggggg agatgaagtt ggagcccttg tttttgacat tggatcctat actgtgagag 240 ctggttatgc tggtgaggac tgccccaagg tggattttcc tacagctatt ggtatggtgg 300 tagaaagaga tgacggaagc acattaatgg aaatagatgg cgataaaggc aaacaaggcg 360 gtcccaccta ctacatagat actaatgctc tgcgtgttcc gagggagaat atggaggcca 420 tttcacctct aaaaaatggg atggttgaag actgggatag tttccaagct attttggatc 480 atacctacaa aatgcatgtc aaatcagaag ccagtctcca tcctgttctc atgtcagagg 540 caccgtggaa tactagagca aagagagaga aactgacaga gttaatgttt gaacactaca 600 acatccctgc cttcttcctt tgcaaaactg cagttttgac agcatttgct aatggtcgtt 660 ctactgggct gattttggac agtggagcca ctcataccac tgcaattcca gtccacgatg 720 gctatgtcct tcaacaaggc attgtgaaat cccctcttgc tggagacttt attactatgc 780 agtgcagaga actcttccaa gaaatgaata ttgaattggt tcctccatat atgattgcat 840 caaaagaagc tgttcgtgaa ggatctccag caaactggaa aagaaaagag aagttgcctc 900 aggttacgag gtcttggcac aattatatgt gtaattgtgt tatccaggat tttcaagctt 960 cggtacttca agtgtcagat tcaacttatg atgaacaagt ggctgcacag atgccaactg 1020 ttcattatga attccccaat ggctacaatt gtgattttgg tgcagagcgg ctaaagattc 1080 cagaaggatt atttgaccct tccaatgtaa aggggttatc aggaaacaca atgttaggag 1140 tcagtcatgt tgtcaccaca agtgttggga tgtgtgatat tgacatcaga ccaggtctct 1200 atggcagtgt aatagtggca ggaggaaaca cactaataca gagttttact gacaggttga 1260 atagagagct gtctcagaaa actcctccaa gtatgcggtt gaaattgatt gcaaataata 1320 caacagtgga acggaggttt agctcatgga ttggcggctc cattctagcc tctttgggta 1380 cctttcaaca gatgtggatt tccaagcaag aatatgaaga aggagggaag cagtgtgtag 1440 aaagaaaatg cccttgagaa agagttccca agcttctacc ttccttttgt caccttacgt 1500 ttcatagctt tagtatactc aggaaaagaa tgaccatctt ttgtagaatg tttatacatt 1560 tttgcatatt tcaatttcca cttaaatttt ttaaagcttt aactggctct ataaattaag 1620 tttgtgcttt ccttgaaatg cacttattct tattacaagc attttataat tttgtataaa 1680 tgtctatttt ctctaaatat tttgctttca gtaaaatgct ttccaactct gtttagtgta 1740 ttaattacca gtggattggt agaactgctt tttattgact agtaaaagtt actgcctatg 1800 ctttttacct taggcttaca gaattaaata aaaattagcc attccagaaa tata 1854 <210> 6 <211> 8475 <212> DNA <213> ADARB2 <400> 6 caaagtggct ggtgccaaac aactagcaga ggcgcaaaag tagcctccct gcgctgggag 60 cccagagcag gaggcagagc ccgcgggaag ctcggagcac tcaggacgcc gcgcgccctt 120 ccccgccctc cctgaccagg gagcagctcg ctccaggcgc ccagccgagg cccccagccc 180 agtgggagca agtcatagag aacaattcga gagacagaga gacggagcgc gctttcctgc 240 tcagtcctga aaagtgagcc gctcccgggt ttgcaacctc aagcttcgca gcagcggcgg 300 cggcggctgc cgggaaggag gcaggtgcag gtgcaggagg gaggcggctc tgggctccgc 360 gcctgggtct cggccatggc ctcggtcctg gggagcggca gagggtctgg agggctgagc 420 agtcaactca aatgcaagtc caagaggagg aggaggcgga ggtccaagcg gaaagataaa 480 gtaagcatat tgtcaacctt cctcgctcct ttcaagcacc tgagtcctgg catcacaaac 540 acggaggatg acgacaccct cagtaccagc agcgcggagg tgaaggagaa ccgcaacgtg 600 ggcaacctgg ccgcgcggcc accgccctcc ggggaccggg cccggggcgg cgcgcccggc 660 gcgaagagga agcggccgct ggaggagggg aatgggggcc acttgtgcaa actgcagctg 720 gtctggaaga agctgtcgtg gtcggtggcg cccaagaacg cgctggtgca gctgcacgag 780 ctgaggccgg gcctgcagta ccggacagtg tcgcagacgg gcccggtgca tgccccggtc 840 ttcgcggtag cggtggaggt gaacgggctc acgttcgagg gcacaggccc caccaagaag 900 aaggccaaga tgcgcgcggc ggagctggca ctcaggtcct tcgtgcagtt ccccaacgcc 960 tgccaggcgc acctggccat gggcgggggc ccgggccccg gcacggactt cacctccgac 1020 caggccgatt tccccgacac gctcttccag gagttcgagc ccccggcgcc gcgccccgga 1080 ctcgcgggag gccgccccgg ggacgccgcg cttctgtccg cggcctacgg gcgacggcgg 1140 ctgctgtgcc gcgcgctgga cctggtgggc ccgacccccg ccacccccgc ggccccgggc 1200 gagcgcaacc ccgtggtgct gctgaaccgc ctgcgcgccg ggctgcgcta cgtgtgtctg 1260 gcagaaccgg ccgagcggcg cgcgcggagc ttcgtgatgg ccgtgagcgt ggacggcagg 1320 acgttcgagg gctcggggcg cagcaagaag ctggcccggg gtcaggccgc gcaggccgca 1380 ctgcaggagc tgttcgacat ccagatgccc ggccacgcgc ccggcagggc caggaggacg 1440 ccaatgccgc aggaattcgc agactccata tcccagctgg tcacacagaa gttccgcgag 1500 gtgacgacgg acctcacgcc catgcacgcc cgccataaag cgctggcagg aatcgtcatg 1560 accaaaggcc tggatgctcg gcaggcgcag gtcgtggccc tgtcctcggg gaccaagtgc 1620 atcagcggcg agcacctcag tgaccagggg ctggtggtga atgactgcca cgcggaggtc 1680 gtggcccggc gggcgttcct gcacttcctc tacacgcagc tggagctgca cctgagcaag 1740 cggcgcgagg actcagagcg atcgatattc gtgcggttaa aagaaggtgg ctaccggctg 1800 cgagagaaca tcctcttcca tctctacgtg agcacctccc cctgtggaga cgcaagactc 1860 cactctccct acgagatcac cacagacctg cacagcagca aacacctcgt caggaagttc 1920 cgcgggcacc tgcgcaccaa gatcgagtcc ggggaaggga cggtccccgt gcgtggcccc 1980 agcgcagtgc agacctggga cggcgtcctg ctgggggagc agctgatcac catgtcctgc 2040 acggacaaga tcgccaggtg gaacgtcctg gggctgcagg gcgcgctcct gtccccacttc 2100 gtggagcccg tgtacctgca gagcatcgtg gtgggcagcc tgcaccacac gggccacctc 2160 gcacgcgtca tgagccaccg catggagggt gtcggccagc tgcccgcctc ctaccggcac 2220 aaccggcctc tcctcagcgg cgtgagtgac gccgaggcgc gccagccggg gaagtcgccc 2280 cccttcagca tgaactgggt cgtgggcagc gcggacctgg agattatcaa cgccaccact 2340 gggcggagga gctgtggggg cccatcccgg ctctgcaagc acgtgctgtc tgcacggtgg 2400 gcgcggctgt atggcaggct gagcacacgg acacccagcc ctggagacac gccctccatg 2460 tactgtgagg ccaagctggg ggcgcacacc taccagtctg tgaaacagca gctgttcaag 2520 gcctttcaga aggctggcct gggcacctgg gtgaggaaac caccggagca gcagcagttt 2580 ctactgactc tctaggctgc gggctcctgg ctgctggagc tgagcgggac gctggaggga 2640 tgggaccgtg tctggggggc gacgtggcgg gtcggccggt tccctgcatt cgttttactt 2700 tggtgtccca gaaacacgcg agtgtgcaat gtttggacga gcaacaacac aaattcagaa 2760 cgtgcctctt tccagatcgc tggccccaga accctgtccc ccacacccag gggcacatgc 2820 actgttgagt tagcgccgac tcttcctgtg gagtctgagg gaggggctcc attcaggcaa 2880 aggggtttta gctgcagcct tggaaggagg caccgacacg acaccaggca ggagtgagcc 2940 tcaggccccg tccctgcacc ccacccctgc gtgcgcctct tggtgatgct ggggtctcac 3000 tagcttgagg gggcacatga agataagcca caaatgaaga gaaaagccat gcccacccca 3060 gccccagaga aaccaataag aatcctctat tattttcact attcatttag gtttttatac 3120 tccacctcct ttcaaaaaag atttaagatg tacgacatta ccgaacacct aaaatagaac 3180 cagagaaacg aaagccattc ccacaaagtg aaggaacagt ttccaaaacc cctgcgaggc 3240 agagttaaga cctgtgacgt ggggagcctg gaaacacccg gcccacgcgt gctgcagatg 3300 tggggagcct ggaaacaccc ggcccacgcg tgctgcagat gtggggagcc tggaaacacc 3360 cggcccacgc gtgctgcaga tgtggggagt ctggaaacac ccggcccacg cgtgctgcag 3420 atgtggggag cccggaaaca cctggcccat gcctgttcag tccgtcatgg cgtttggttt 3480 atggtggccg atactaagag ccactgaggt ctgggttgtg taagggttag ctaccaccct 3540 ataacctccc taccaggtaa taaggagacc aagtctttga tcaaattctg attttttaac 3600 taaattttca ttagaaagca agcacaaaat aaaatcaaaa caacctttac cttcagcttg 3660 agaggctacc agctctctat tctttcagat tctccaatca acaccttgca ggacaagacc 3720 ccaaaaaagt tcagctgtca aaaaatgtaa gaggcaggat tctgtgaccc tcagagcagg 3780 cttccaacac cagagacctt cagctcacag tggagatggg acatgggggc tttagcccac 3840 agcatcatcc ctgagagcca aggcgctgta ttcatacggg gtcaggctct tttccaagta 3900 tctttacgta atccatgtac ctcgagctgc tgtcatctca cctccgagaa ctcatttcta 3960 acatcatca tgctagatag ccagtctctc atttctccaa cttaaaaaat ccatctctga 4020 aattcatgac agtgatggca gacggcaaag catggtggtg tccacctctg gggtgtgggc 4080 ttcccggaaa gaatcccagc tgaccacccc agaaagtgca agaataacat tgtgctgtac 4140 atagtcaagt gctataaatt acagttatca taatgagaag gcagaaatga aactgagttg 4200 tagctatttg ttacaagata ataagaagta gagatattag tatggaaaaa gaaacttttc 4260 ctgggattta aaatcaggcc aaatttatca ctcgagttct tttagaaaag aaaacaggta 4320 ctggagtaga caacttcttc cagataaagt ttcaaaagat acgagaacat tttttcaaat 4380 aaaggactca cattaatctt ttataaaaat cacaaaaata aatgaaatct taattcagtg 4440 caaaagctaa gctcaaacga ccagtttcta ttaagttctg gtaacttgac atcactagga 4500 tgaagcttag agaacttaga gtcgagaggt gatgggtggc tcagacattc gcagcagtca 4560 gaagtgagcg ctcccctgaa tgcgtgggag cacggccagc tcctggctga agtctcccac 4620 ccaggcctca aatcaccttc atctgagatg ttggctagag aagcatataa tgctttgtcc 4680 cagtgggctc caaatcacgc tgtttctgca gcgagggggc ctgtgttgta agcagatttc 4740 actgtcacag ggaagacgca gggtctgatt cacgggactc ggaaagcgct cggccaccca 4800 gtggccagca tcatgaagcc acagctgggg ggttgggatt cgttttgtct caggcattga 4860 ccttccagaa acaactcaga ctttactgaa atatcaacat ccacatctgg agaaagccac 4920 acattaattc catgctaccc attagtacaa gtgtatggat tcgtgtatta agtccacagg 4980 agactccatg gaaggagaga ttaaagctct tcagagaagg ccgatagcga cagaagagtt 5040 tccaatgcag ccagagtgag gttgaggtgc cggagccttt ccgtggaggg atctgtcaga 5100 ggggatgtgg gctgcagagg ggaccccacg taaggaaagg agggtcccag gccctgggta 5160 gtgaaaggag aaggtagtcg aggcagtcaa gggtgaccct acacgcagga ggcacgccac 5220 accagatcac gccacacgca ggctgctccc aactggcagg gcctgaccca gccaggaagg 5280 gccaggtcct aggattccac agtgccagga gtgcccgaag gggccaggtc ccaggattcc 5340 cacagcccca ggtgtgcctg gaagacccgg gtcccaggat tcccacagcc ccagctatgc 5400 ttgggggggc cgagtcccag gattcccaca gccccaggtg tgcctggaag acccgggtcc 5460 caggattccc acagccccaa gagttcccgg aagagctggg tcccaggatt cccacagccc 5520 cagctatgct tggggggggcc gggtcccagg attcccacag ccccaggtgt gcctggaaga 5580 cccaggtccc aggattccca cagccctgga tgtgcctgga ggggctgtgc cacctctgca 5640 gagatggaag ggctcgtgtt gaagcctgag gatttcgccc tcaggtccag gtcagaacat 5700 cccagcacca ctttcaggcc atgtctgccc tgcagttttg accactgaat tggtcttaag 5760 agtggccacc cattcccctc caagtgaggg ggcaagacac aagtagggga cgggtcactt 5820 tctgtcaccc tgaaaatacg ctgggcacga cacaagtagg ggatgggtca ctttctgtca 5880 ccctgaaaat acgctgggca cgacacaagg ggggctgatg aagtcaggcc cgcccctcca 5940 agtccacctc gaaatcaccg tctggcttcc tcgcacttcc caccacctga caccgccaag 6000 ccccttgctt cagattttct gtggtctgta ttcataccct tgcttcagat tttctgtagt 6060 ctatattcat gcctgcttag gcccctacaa aagtcctcat aaaaccagca ccacctttat 6120 ctgcctccaa aacacacact gctttcccat caggaagatc agcaatgtgg tttccggcct 6180 ggttcttagt caaaaagtta gtgtctggtg gtttctggcc tttttgcagg acggggcgca 6240 gggaacggct gcgcggccag gcagcctccg ctgtccacct ccagccccgg ttttgcagcc 6300 gtgtgtgata tcaagggata gagttagggt ttctgtgggt tttgtttttg ctgaggaaag 6360 gatgtgcagg tcgatagcta ttgtttcctt tccattcctg tgattctctt tacatctgta 6420 tatatctatc acaccatgct gactttgtga tgagtcctgt tcctcagaaa catcaagctg 6480 ggttcctttt caaagaaaca cacagatcat atttctccat ctcattttgt tttcacaggg 6540 agcttttctt atcaacaaag tcgcatgctt ttttttttgg atataatgtt tatcacgtct 6600 ggagagccat aaacagtaaa tacagaggat atcaatgccc agaatagtta ttttgatgaa 6660 atcctatttt tagataataa atttcaagat gtgtctatag tgtattgttt aaaacaactg 6720 aagacatttg agacgtacat aaagtagaca tttttaattt agggaaactt atatgccctt 6780 ttttaagaag ccattctaat aaaataatct gactaattgg cccaaaatac aataagtatc 6840 actttctaac agagaccaaa gggaagctga gaggctttcc ttttatgtac taccgttgga 6900 tcgctgcagc cgcctctcat aacacccaac agaacccggt gaggctctgt gggcttcccg 6960 cggccctcag ggaggctgca gagtccccta gtccatgtca gggagccgcc atcccacata 7020 cctccaaagc ctgtcctcgc ctgcagtttt tgcagagctc gcggttggag gtggaaattt 7080 agaagccctg tgttgcagga gaggcagtag cacccccagg cagctcttag cagggacaga 7140 ccaccccccg cctcgctggt attttagggt cttttggtat tttgccactg tgtggggcta 7200 ggcgggtggc tggaggacac ggtgtaggcc ttgccgctgt ctgggttcct cgccactgca 7260 ggagcagggc tgtttctgga aacactgggc tgctggtgac ccgtcaaact tctcccacaa 7320 attctgaatc cgagaaagtg aaggaaggat ggtggggaag tgaggaggca ggagcagagg 7380 ccacagggac caaccagaga tgcggtggag acagaggagc ttccttctca ggctgtttct 7440 gggaagcctg agaggcggcc agcaccaccc tccgctcact ctcccctcag cctcttcgct 7500 tcccttctca accctttctc tcctcctcgc ctcttccctt tcttgctgtc ttgttagtcc 7560 ctgtcccaaa actcctggct cctttgttct gctgccgtgg cccccaccca ggaggaggtc 7620 tcaggcacca tccccccacg agggatccac acaacaggtt catgctgggg ctgggggagc 7680 cccgctgggt tcctgatgcc ttgtgcacag ggagttgctg cagtcatttt tggactctcc 7740 tgaatgtgtc cacatgttct gacctcccac cagaaggaac gctggtggcc acatctctag 7800 agatctattt acttttttga gaccggctta tgagattggc taatttttgt atttttggta 7860 gagatggggt ctcaccatgt tgcccaggct agtctcgaac tcctggcctc aagtgatctg 7920 cccacctcgg cctcccagag tgctgggatt acaggcatga gccaccgcgc tggcctctag 7980 agattcacac caaacaatat cactcctgcg ggaaccgcag acagatcaaa ccctggtgag 8040 aggaacactt tatttcccaa ctcatcatcc taagccaagg ttggagggat gagcattccc 8100 taaacaccaa ggcgagatca cctggtccca gtgcctcttt tcaacacaggc cctagatttc 8160 tatctctctg cagtttatgc atcggtaaaa aaaaaaaaat ctctcccagt gtgccccgtt 8220 agttttcagc attttgtaag caaaatgaac ttaacacata gtaattctaa ttgaaggtat 8280 gtacataaaa agcatgatag aatggcaata ttgtatcaat ggatgtacat ttgtaatatt 8340 tgtaaaaaaa aatccaaaac cttaaaatat gaatttacat gttaatttgc ctctaagttc 8400 tataaattgc acttcagtga tatctaataa gtgaatgttt ctgttaagta aataaaaata 8460 ttcagtaaaa ttgtt 8475 <210> 7 <211> 4617 <212> DNA <213> ANKRD30B <400> 7 caagagcttg gcgatacaga aatttctgct ggtgttgggg cgggtgcggg aactgaagac 60 gggcgagtgc gagccggggg cgggtgctgg ggaagggtaa gcgggaagcg agggcgaggg 120 gtaggggctg gggaagggcg agcgggaggc gcgggctctc tctagcaggg ggctgcagcc 180 atgaagaggc tcttagctgc cgctggcaag ggcgtgcggg gcccggagcc cccgaacccc 240 ttcagcgaac gggtctacac tgagaaggac tacgggacca tctacttcgg ggatctaggg 300 aagatccata cagctgcctc ccggggccaa gtccagaagc tggagaagat gacagtaggg 360 aagaagcccg tcaacctgaa caaaagagat atgaagaaga ggactgctct acactgggcc 420 tgtgtcaatg gccatgcaga agtagtaaca tttctggtag acagaaagtg ccagcttaat 480 gtccttgatg gcgaagggag gacacctctg atgaaggctc tacaatgcga gagggaggct 540 tgtgcaaata ttctcataga tgctggtgct gatctaaatt atgtagatgt gtatggcaac 600 acggctctcc attatgccgt ttatagtgag aatttgttaa tggtggcaac actgctgtcc 660 tatggtgcag tcatcgaggt gcaaaacaag gctagcctca cacccctttt actggccata 720 cagaaaagaa gcaagcaaac tgtggaattt tactaacaa aaaatgcaaa tgcaaacgca 780 tttaatgagt ctaaatgcac agccctcatg cttgccatat gtgaaggctc atcagagata 840 gtcggcatgc ttcttcagca aaatgttgac gtctttgctg aagacataca tggaataact 900 gcagaacgtt atgctgctgc ttgtggagtt aattacattc atcaacaact tttggaacat 960 atacgaaaat tacctaaaaa tcctcaaaat accaatccag aaggaacatc tacaggaaca 1020 cctgatgagg ctgcaccctt ggcggaaaga acacctgaca cggctgaaag cttgctggaa 1080 aaaacacctg acgaggctgc acgcttggtg gagggaacgt ctgccaaaat tcaatgtctg 1140 gggaaagcaa catctggaaa gtttgaacag tcaacagaag aaacacctag gaaaattttg 1200 aggcctacaa aagaaacatc tgagaaattt tcatggccag caaaagaaag atctaggaag 1260 atcacatggg aggaaaaaga aacatctgta aagactgaat gcgtggcagg agtaacacct 1320 aataaaactg aagttttgga aaaaggaaca tctaatatga ttgcatgtcc tacaaaagaa 1380 acatctacaa aagcaagtac aaatgtggat gtgagttctg tagagcctat attcagtctt 1440 tttggcacac ggactattga aaattcacag tgtacaaaag ttgaggaaga ctttaatctt 1500 gctaccaaga ttatctctaa gagtgctgca cagaattata cgtgtttacc tgatgctaca 1560 tatcaaaaag atatcaaaac aataaatcac aaaatagaag atcagatgtt cccatcagaa 1620 tccaaacgag aggaagatga agaatattct tgggattctg ggagtctctt tgagagttct 1680 gcaaagactc aagtgtgtat acctgagtct atgtatcaga aagtaatgga gataaataga 1740 gaagtagaag agcttcctga gaagccatct gccttcaagc ctgccgttga aatgcaaaag 1800 actgttccaa ataaagcctt tgaattgaag aatgaacaaa cattgagagc agctcagatg 1860 ttcccatcag aatccaaaca aaaggacgat gaagaaaatt cttgggattc tgagagtccc 1920 tgtgagacgg tttcacagaa ggatgtgtat ttacccaaag ctacacatca aaaagaattc 1980 gataccttaa gtggaaaatt agaagagtct cctgttaaag atggtcttct gaagcctacc 2040 tgtggaagga aagtttctct tccaaataaa gccttagaat taaaggacag agaaacattc 2100 aaagcagagt ctcctgataa agatggtctt ctgaagccta cctgtggaag gaaagtttct 2160 cttccaaata aagccttaga attaaaggac agagaaacac tcaaagcaga gtctcctgat 2220 aatgatggtc ttctgaagcc tacctgtgga aggaaagttt ctcttccaaa taaagcttta 2280 gaattgaagg acagagaaac attcaaagca gctcagatgt tcccatcaga atccaaacaa 2340 aaggatgatg aagaaaattc ttgggatttt gagagtttcc ttgagactct cttacagaat 2400 gatgtgtgtt tacccaaggc tacacatcaa aaagaattcg ataccttaag tggaaaatta 2460 gaagagtctc ctgataaaga tggtcttctg aagcctacct gtggaatgaa aatttctctt 2520 ccaaataaag ccttagaatt gaaggacaga gaaacattca aagcagagga tgtgagttct 2580 gtagagtcca cattcagtct ttttggcaaa ccgactactg aaaattcaca gtctacaaaa 2640 gttgaggaag actttaatct tactaccaag gagggagcaa caaagacagt aactggacaa 2700 caggaacgtg atattggcat tattgaacga gctccacaag atcaaacaaa taagatgccc 2760 acatcagaat taggaagaaa agaagataca aaatcaactt cagattctga gattatctct 2820 gtgagtgata cacagaatta tgagtgttta cctgaggcta catatcaaaa agaaataaag 2880 acaacaaatg gcaaaataga agagtctcct gaaaagcctt ctcactttga gcctgccact 2940 gaaatgcaaa actctgttcc aaataaaggc ttagaatgga agaataaaca aacattgaga 3000 gcagattcaa ctaccctatc aaaaatcttg gatgcacttc cttcttgtga aagaggaagg 3060 gaacttaaaa aagataactg tgaacaaatt acagcaaaaa tggaacaaac gaaaaataag 3120 ttttgtgtac tacaaaagga actgtcagaa gcgaaagaaa taaaatcaca gttagagaac 3180 caaaaagcta aatgggaaca agagctctgc agtgtgagat tgactttaaa tcaagaagaa 3240 gagaagagaa gaaatgtcga tatattaaaa gaaaaaatta gacccgaaga gcaacttagg 3300 aaaaagttag aagtgaaaca acaacttgaa cagactctca gaatacaaga tatagaattg 3360 aaaagtgtaa caagtaattt gaatcaggtt tctcacactc atgaaagtga aaatgatctc 3420 tttcatgaaa attgcatgtt gaaaaaggaa attgccatgc taaaactgga agtagccaca 3480 ctgaaacatc aacaccaggt gaaggaaaat aaatactttg aggacattaa gattttacaa 3540 gaaaagaatg ctgaacttca aatgacccta aaactgaaac agaaaacagt aacaaaaagg 3600 gcatctcagt atagagagca gcttaaagtt ctgacggcag agaacacgat gctgacttct 3660 aaattgaagg aaaaacaaga caaagaaata ctggagacag aaattgaatc acaccatcct 3720 agactggctt ctgctttaca agaccatgat caaagtgtca catcaagaaa aaaccaagaa 3780 cttgctttcc acagtgcagg agatgctcct ttgcaaggaa taatgaatgt tgatgtgagt 3840 aatacaatat ataacaatga ggtgctccat caaccacttt atgaagctca aaggaaatcc 3900 aaaagcccaa aaattaatct caattatgca ggagatgatc taagagaaaa tgcattggtt 3960 tcagaacatg cacaaagaga ccgatgtgaa acacagtgtc aaatgaagaa agctgaacac 4020 atgtatcaaa atgaacaaga taatgtggac aaacacactg aacagcagga gtctctggag 4080 cagaaattat ttcaactaga aagcaaaaat aggtggcttc gacagcaatt agtttatgca 4140 cataagaaag ttaacaaaag caaggtaaca attaatattc agtttcctga gatgaaaatg 4200 caacgtcatc taaacgagaa aaatgaggag gtattcaatt atggtaacca tttaaaagaa 4260 cgtatagatc aatatgaaaa agagaaagca gaaagagaag taagtatcaa aaaatataaa 4320 tacttttcaa acttcctgaa agaaagtggc cttggctaaa tgctgaatct agttgaatat 4380 atatatatat aaatagatga taaatgtact tactatatca gcttagaaac atgcctcatt 4440 tccaccaaat gaaagtgaaa gctaagagac gttttacttt gagtaaaggt attgtgtcac 4500 tgatgaaatt ataagagttt aagttaaaga tttttaatag attaacatta atgacattgg 4560 cttatactgc tgaaataaag gttttaatgt ctctttgtgg ccacattttt tgactac 4617 <210> 8 <211> 3270 <212> DNA <213> ARHGAP10 <400> 8 ggggcgccgc agctagcgct ggtctcggtg gcagctcctc cgcgccgcag gactcggctc 60 tacgggacat gtccgtgccg cgctcgccgc gcgcccgggc ctgctagctc ctctgtgctc 120 cctgaacgcg cggcgccgca cctggcagcg gcctcggagc tcggctcggg caggagcgcg 180 cggccgtgcg caccgcgcag cgaccgctgc cgtcatgggg ctgcagcccc tggagttcag 240 cgactgctac ctcgacagcc cgtggttccg ggagaggatc cgcgctcacg aagcggaact 300 cgagaggacc aacaagttca tcaaagagct cattaaggac gggaagaacc tcatcgctgc 360 gacgaaaagt ctgtcagtgg cccagcggaa gtttgctcat tcactcagag actttaagtt 420 tgagtttatc ggtgatgctg tgacagatga tgaacgatgc atagatgctt ccttacgtga 480 attttcaaat tttttgaaga atctggagga acagagagaa attatggcat taagtgtaac 540 tgaaaccctg attaaaccct tggaaaaatt cagaaaagag caacttggag ctgtaaagga 600 agaaaaaaag aagtttgaca aagagacaga aaagaattat agtctaattg ataaacattt 660 gaatttatca gcaaaaaaga aagactcaca tttacaagag gcagatatcc aagtagagca 720 gaaccggcaa cacttctatg aactgtctct cgagtatgtg tgtaagctgc aggaaatcca 780 agaaagaaag aagtttgagt ttgtggaacc tatgctgtca ttttttcagg ggatgtttac 840 cttctatcat cagggccatg aacttgccaa agacttcaat cactacaaaa tggaactaca 900 gatcaacatt cagaatacac ggaatcgatt tgaaggaaca aggtcagaag tggaagagct 960 catgaacaaa atcagacaga atcccaagga ccacaaacga gcaagtcagt ttacagccga 1020 aggctacctg tatgtccagg aaaaaaggcc tgctccgttt ggttccagtt gggtcaaaca 1080 ctattgcatg tatcgaaaag cagcaaagaa gttcaacatg atcccatttg agcacagatc 1140 tggagggaaa cttggggacg gagaggtgtt ctttttgaaa gaatgtacca agaggcatac 1200 tgactccatt gacagaaggt tttgttttga catagaagct gctgatcggc ctggcgtttc 1260 cttgaccatg caggcatttt ccgaagagga aaggaagcag tggttggaag ctctgggtgg 1320 aaaggaagct ctgtcccata gttttaatac agccatcatc ccaagaccag aaggaaatgc 1380 acagttggat aagatggggt tcacaattat cagaaaatgc atcagtgccg ttgaaacacg 1440 aggtataaat gaccaaggat tgtacagagt tgtgggggtg agttcaaagg tccagagact 1500 tctgagtatg ttgatggatg taaaaacatg caatgaggtg gacctggaga attctgcaga 1560 ttgggaagtg aagacaataa caagtgcctt gaaacagtat ttgaggagtc ttccagagcc 1620 tctcatgacc tatgagttac atggagattt cattgttcca gccaaaagcg gcagcccaga 1680 atctcgtgtt aatgcgatcc atttcttggt acacaaactg ccagagaaga ataaagagat 1740 gttggatatt ttggtgaaac acttaacaaa tgtttcaaat cactccaagc agaacctgat 1800 gactgtggca aacttaggag tggtgtttgg accaactctg atgaggccac aggaagaaac 1860 tgtcgctgcc ctcatggact tgaagtttca gaatattgtt gtggaaatct taattgaaaa 1920 ccatgaaaag atttttcgga cgccgcccga tactacattc cctgagccca cctgcctgtc 1980 agcatcaccc ccaaatgcgc caccaaggca gtcgaagaga caaggccaga gaaccaagag 2040 gcccgtggcc gtctacaatc tttgtctgga gctggaagat ggtgacaatc cttacccttc 2100 caaggaggac acccctacca gcagtctgga ctcactttcc tccccgtctc ccgtgactac 2160 agctgtccct gggcctcctg gaccagacaa aaaccacctt ctggcagatg gagggagctt 2220 tggagactgg gcatccacta tcccaggcca gacccgatcg tctatggtcc agtggcttaa 2280 cccacagtct ccaaccacaa caagctccaa ctcagctgtg acacctcttt cacccgggtc 2340 gtcccctttc cccttttctc ctcctgctac tgtagcggac aagccacctg aaagcatccg 2400 cagtcggaag gctcgagccg tgtatccgtg tgaagcagaa cacagctcgg aattatcttt 2460 tgaaatagga gcaatttttg aggatgtaca aacctccagg gaacctggct ggctagaagg 2520 gactctgaac ggcaagaggg ggctgattcc acagaactac gtcaagctgc tgtagctcct 2580 ggcctcagag cccctgctga ccctggcacc cagggacctg cctgggggca gagagctgtc 2640 ttcctcctcc gaggctctgg gctgcaccca caggtacctc cacacttggg agttaccatc 2700 atcacagtca gccctggggg tggggggtgg tgggcaggga tgggacgcac cacacagaac 2760 tgtgattgtg gatcaggagg ggaatgtcag gattcgcaaa atggactttt catttgtcaa 2820 gtattgggac ttgtgatttt taattatcca gcatatagaa tgagagggag ggcagccttc 2880 tgccacctgt gtcgcctcca ctggcagtca cgccaccaga gccaccctgg ctccctctcc 2940 tccctgagca cctgctgctg cgattttaaa gggaactgta ctactcgcag tgataggttt 3000 gcagagtgtg tgcttggctg tggcagccta gcttggagaa gctgctgttg gtgcaaggga 3060 gatggtctca agtcagaggg aagcagagac gcgcgtctca agcctgccct tcctagacgg 3120 ccacctgcag gaccccacac tcactgcact ggcagcgtgc actggcgtat ttgtaacagg 3180 cttctcggtg ctcctcaccc gtgtgctgtt ttccaaacac cacctttttg cctcaaggtc 3240 tctgtaaatg aaataaactg taatttacta 3270 <210> 9 <211> 8746 <212> DNA <213> ATRNL1 <400> 9 agttggcgcg ggccgcgggc gaggcggggc cgcgcgcggg gtcccctcct cctgccggtc 60 aggtcccctc aggagcgccg ggcgcagtct gcgcctcccg ctccccgcct ccggccgggt 120 ccgggacgcc gcggctgtgg ggtcggcccg ctaaggacaa ggtcgggaga ctgggtggcg 180 atgcccgagt gcgactggag gcagccgagc ggaggcgacg gcggttggga tctgtccctc 240 ctgaccgggg agcgggactc ggacgggcgc cggtgaggag gaggagaagc ggcggcggag 300 aggttttctg cggccggaat tcccttcaac agcatccctg tcggcgcccg cgagcgcagt 360 ctcgccgggc aggggcgccg gggaagatgg agactggggg ccgggcccgc actggtaccc 420 cgcagccagc ggccccgggg gtgtggaggg ctcggccggc gggcggcggc ggcgggggcg 480 cctcctcctg gctgctggac gggaacagct ggctgctgtg ctatggcttc ctctacctgg 540 cgctctacgc gcaggtgtcc cagtccaagc cgtgcgagag gaccggctcc tgcttctcgg 600 gccgctgtgt caactccacc tgcctctgcg acccgggctg ggtgggggac cagtgccagc 660 actgccaggg caggttcaag ttaacagaac cttctggata tttaacagat ggcccaatta 720 actataaata taaaactaaa tgtacttggc tcattgaagg ctatccaaat gcagtgttaa 780 gattaagatt caatcatttt gctacagaat gtagctggga tcatatgtat gtttatgatg 840 gagatcaat atatgcacct ttaatagctg tacttagtgg tttgatagtc cctgaaataa 900 ggggcaatga aactgtgcct gaagttgtta ctacatctgg ctatgcactg ttacattttt 960 ttagtgatgc tgcgtataat ctaactggtt tcaacatttt ctattcaatc aattcttgtc 1020 ctaacaattg ctctggtcat gggaagtgta caactagtgt ctctgttcca agtcaagtat 1080 attgtgaatg tgataaatac tggaagggtg aagcttgtga tattccttac tgtaaagcca 1140 attgcggcag tccagatcac ggttactgtg acctgactgg agaaaaatta tgtgtctgca 1200 atgatagttg gcaaggtcct gattgttctt tgaatgttcc ctctactgag tcttactgga 1260 ttctgccaaa cgttaaaccc ttcagtcctt ctgtaggtcg ggcttcacat aaagcagttt 1320 tacacgggaa atttatgtgg gtgattggtg gatatacttt taactacagt tcttttcaaa 1380 tggtcctaaa ttacaattta gaaagcagta tatggaatgt aggaactcca tcaaggggac 1440 ctctccagag atatggacac tctcttgctt tatatcagga aaacatcttt atgtatggag 1500 gcagaattga aacaaatgat ggcaatgtca cagatgaatt atgggttttt aacatacata 1560 gtcagtcatg gagtacaaaa actcctactg ttcttggaca tggtcagcag tatgctgtgg 1620 agggacattc agcacatatt atggagttgg atagtagaga tgttgtcatg atcataatat 1680 ttggatattc tgcaatatat ggttatacaa gcagcataca ggaataccat atctcatcaa 1740 acacttggct tgttccagaa actaaaggag ctattgtaca aggtggatat ggccatacta 1800 gtgtgtatga tgaaataaca aagtccattt atgttcatgg agggtataaa gcattgccag 1860 ggaacaaata tggattggtt gatgatcttt ataaatatga agttaacact aagacttgga 1920 ctattttgaa agaaagtggg tttgccagat accttcattc agctgttctt atcaatggag 1980 ctatgcttat ttttggagga aatacccata atgacacttc cttgagtaac ggtgcaaaat 2040 gtttttctgc cgatttcctg gcatatgaca tagcttgtga tgaatggaaa atactaccaa 2100 aaccaaatct tcatagagat gtcaacagat ttggacactc tgcagtagtc attaacgggt 2160 ccatgtatat atttggggga ttttctagtg tactccttaa tgatatcctt gtatacaagc 2220 ctccaaattg caaggctttc agagatgaag aactttgtaa aaatgctggt ccagggataa 2280 aatgtgtttg gaataaaaat cactgtgaat cttgggaatc tgggaatact aataatattc 2340 ttagagcaaa gtgccctcct aaaacagctg cttctgatga cagatgttac agatatgcag 2400 attgtgccag ctgtactgcc aatacaaatg ggtgccaatg gtgtgatgac aagaaatgca 2460 tttcggcaaa tagtaactgc agtatgtctg tcaagaacta caccaaatgt catgtgagaa 2520 atgagcagat ttgtaacaaa cttaccagct gtaaaagctg ttcactaaac ttgaattgcc 2580 agtgggatca gagacagcaa gaatgccagg ctttaccagc tcatctttgt ggagaaggat 2640 ggagtcatat tggggatgct tgtcttagag tcaattccag tagagaaaac tatgacaatg 2700 caaaacttta ttgctataat cttagtggaa atcttgcttc attaacaacc tcaaaagaag 2760 tagaatttgt tctggatgaa atacagaagt atacacaaca gaaagtatca ccttgggtag 2820 gcttgcgcaa gatcaatata tcctattggg gatgggaaga catgtctcct tttacaaaca 2880 caacactaca gtggcttcct ggcgaaccca atgattctgg gttttgtgca tatctggaaa 2940 gggctgcagt ggcaggctta aaagctaatc cttgtacatc tatggcaaat ggccttgtct 3000 gtgaaaaacc tgttgttagt ccaaatcaaa atgcgaggcc gtgcaaaaag ccatgctctc 3060 tgaggacatc atgttccaac tgtacaagca atggcatgga gtgtatgtgg tgcagcagta 3120 cgaaacgatg tgttgactct aatgcctata tcatctcttt tccatatgga caatgtctag 3180 agtggcaaac tgccacctgc tcccctcaaa attgttctgg attgagaacc tgtggacagt 3240 gtttggaaca gcctggatgt ggctggtgca atgatcctag taatacagga agaggacatt 3300 gcattgaagg ttcttcacgg ggaccaatga agcttattgg aatgcaccac agtgagatgg 3360 ttcttgacac caatctttgc cccaaagaaa agaactatga gtggtccttt atccagtgtc 3420 cagcttgcca gtgtaatgga catagcactt gcatcaataa taatgtgtgc gaacagtgta 3480 aaaatctcac cacaggaaag cagtgtcaag attgtatgcc aggttattat ggagatccaa 3540 ccaatggtgg acagtgcaca gcttgtacat gcagtggcca tgcaaatatc tgtcatctgc 3600 acacaggaaa atgtttctgc acaactaaag gaataaaagg tgaccaatgc caattatgtg 3660 actctgaaaa tcgctatgtt ggtaatccac ttagaggaac atgttattac agccttttga 3720 ttgattatca atttaccttc agcttattac aggaagatga tcgccaccat actgccataa 3780 actttatagc aaacccagaa cagtcgaaca aaaatctgga tatatcaatt aatgcatcaa 3840 acaactttaa tctcaacatt acgtggtctg tcggttcaac agctggaaca atatctgggg 3900 aagagacttc tatagtttcc aagaataata taaaggaata cagagatagt ttttcctatg 3960 aaaaatttaa ctttagaagc aatcctaaca ttacattcta tgtgtacgtc agcaactttt 4020 cctggcctat taaaatacag attgcattct cacaacacaa tacaatcatg gaccttgtgc 4080 agttttttgt caccttcttc agttgtttcc tatccttatt gctggtggct gctgtggtat 4140 ggaagatcaa acaaacttgt tgggcttctc gacggagaga gcaactgctt cgagaacgac 4200 agcagatggc cagccgtccc tttgcttctg ttgatgtagc tctggaagtg ggagctgaac 4260 aaacagagtt tctgcgaggg ccattagagg gggcacccaa gccaattgcc attgaaccat 4320 gtgctgggaa cagagctgct gttctgactg tgtttctttg tctaccacga ggatcatcag 4380 gtgcccctcc ccctgggcag tcaggccttg caattgccag tgccctaata gatatttcac 4440 aacagaaagc ttcagatagt aaagataaga cttctggagt ccggaatcga aaacaccttt 4500 caacacgtca aggaacttgt gtctgagaaa tggaaaccgc tcctgtatat tctgtactgt 4560 tttacttcgg gcttctgtta aagctgttct atggccttgg attttatgga ggcagatctc 4620 tgtatcatcc agagcctgag tacagtttcc ttccaaatgg acaatgaccc aggtggccaa 4680 agaatgttca tgagttttat aaaagtattg atggtcacag gtgataaagt cagtttttac 4740 cactatctta ggcttattat agctaacatt aaattactct ggaaaaagat gtatattgtt 4800 tcttaatgaa gatgaaaaat atgtaattca tataaatcaa ctgtttatat cccaagactt 4860 gaaagaaaga cattttttaa tgcctgaatg atgagaattg tacagttttt gcctcataag 4920 caaacttgaa tcacctgtgt atgaacaggg aatgaacaca ttgcaatggc tttaaatgct 4980 cttttatctc gttgtaaagg taaggcaaga ttttgatgta gtaggatgta ggtaatgtat 5040 ttaaatattt catatgacca tatcgtgtcc aaactcagtc tgagaatgtg acagctttcc 5100 gcctaactag aatgcagacc agaatgagtt caactcattc tgtgcaactt cacagggggt 5160 ttattagaat gctcagtgta gaggacattc ctgtcatcca tgccaactac ctaactcgtt 5220 atcagagctg atagagcatg gaaaagtctg tccagcgatc agttgttccc ctccttccaa 5280 aaacagcctc caataccaca acctgaaaag agccgaaatg gttattttac agcatacaag 5340 cttctgctcc agtatgataa tttttaattg cctaagaatc attggatcag acctaaatga 5400 tccatctgca tttttataag aatggatctt tctttgccct tcctctccta gctgctagat 5460 tttaactacc ttttacaaat gttacaaaat gtattttaga ggcgacatct ctcaagatga 5520 cctgagttcc ttcctgccaa ctgttccacc tagaatacaa gtagagaaga gcactggctg 5580 gcaagcatca acaggagtct tcttcccaac acgagcgcat ccatgtcctg agaaaaagtc 5640 tgtggtttag aaaatatgtc catggttgcc cacagtcagc acactcttag tgactcaaaa 5700 ttctgaatta tggcagaaag gaaaaataaa acatacttca cattagaaca cagaatcatt 5760 tacatcctaa tactgaccac agttcactaa agctcagtag cattaacaga tatagtttgg 5820 aattgcagtt tcctcacttc agggtgacaa gatatgtata acagtgacag aaatctccaa 5880 agctgctgta tatgatatag ctttgttaaa tatgaaggtc ctttaaatac aattgatgtt 5940 tagtactata tatgtacttt tcacattctt tggatttctg gaaggttatg acactttact 6000 gtttacagct aatgcatagt tacttgcatg ccatggttgt acagtagcag actatgaccc 6060 tattgtgata ttaagtgttt atttcataat gccatttata catagctgaa tttgatgagg 6120 attgaatgtc atatataaga ggaatgatca tacaatatgt agttgcatct tatataagat 6180 ttctaggttg catctaacca tgactatgtc attattttga taattaggca tttatgaatt 6240 atagtatata ttcctcatgt tggcatgata attttgctat tttccatgca ttaaaaataa 6300 gacaaattct tagagtaatt ttagtaattt tatctataat ctgtggggtt tttttggagg 6360 gggaggccac tggttgtttc tacttccctg tgatattttc tctctcatta aaggaatgag 6420 ctaagtttgt aaatatctcc taaaaacaat caagtaattt tattagcttc ttttggaccc 6480 tctaaatatt gacttctctc atgaaaaaat aaattgatga aactaatgat tacaaagata 6540 taatcatttt ttaaaaagtg attgcccaat gtatttctct aacaattgtc acaagagaaa 6600 gcataacaat aaaaatacaa aaacatacag atttagatgt aaaatctata taagctatat 6660 ttttagggag gctaagcaga tagtattact gtggaagaat tatcaagttt tattcacctc 6720 aaatcccact gggttcttaa aacttgaaaa ttcaaattgt agagaattat gagacacaat 6780 gtgatgttta gttaaagtca tgctatacct ttctgggcca catattgcta actctgtggc 6840 taattatgca attaattctc aacgtatcaa agcttttcac tggcagtaaa ttctttgccc 6900 tcaggtgaag tggattgaaa agacatcaag gatcaaggat aatcactttg aatctgttgg 6960 tttttccccc tacattccag acactttaaa tttggatgct ttcatttttt ttaaatcaaa 7020 ccacacaaat atgcagatac tttcccagaa tttcgcagtt aaatggctga tcctcttgaa 7080 aactaacctt aatggaattc taaacatttc agtttagaat gactttgaaa aattccttag 7140 atttttagga tgttttattc tgccaagtat gaaaaaaaaa tggttaaata caatggagtt 7200 ttaaaaatta acctggggat tctatttgaa ctagaaaatt cctattggaa aagaatttgc 7260 acatacttac agattcagct aataaatttt aagaggatta ggattctcat aattctttaa 7320 atgaaaattt gttttagtga tacacagaga tgccgtatac tatagtgtta tgttcagtag 7380 gaaaacttca aatagttcgt atttaaaaag gtaattgatc cttgctgtac ttcccaacat 7440 ctcatcttct tttagctgca gtaagataga ggtgactgta tggctacagt tcatggtata 7500 aggtcattta gggtgcacac tggcacacag gctggaaaac gggcactgga cccagctttc 7560 aggtgtgtgg tgctgggtaa gtttcacctt tgaagcctca gccttccatc tgtaaagggc 7620 ggtaatggtg cccacctttc gaggcattgc gaggctagat ggtaacacac agaaagctcc 7680 cacagtggga ccttgatgca gcgtagctgg tattaacaac cgtggggaca ccaggccact 7740 ctttttctac cagttgtttt atgaatccac ctattaattt tcatccatct tttggtcgta 7800 ggtaaaggtc aatcaggttt ttcaaaaaga ctccctgaat aacttaagtt cctgtatttc 7860 taagatatag ggatttctac aaaacgactt tgacatttag tcaataaaga cttaaactct 7920 tcttaaatct atagttttag gagagttttt cttaaaatta ctgactgatg acattgagac 7980 aagagcatca atgatcacct ttcacgtaca aactaggcaa gacagggtca gtgcttacat 8040 tttgtggtta tacatgatac atcttttctc agtgaacata aaactatgat ttgaaaggtg 8100 tcttatattt aaaaaagatt gtaaaatgaa aactgaccaa atgaactaat tctacccacc 8160 tatggtcttt ttaaatgtcg agtttcaaaa cccatttgcc gtatactaga gtgagcttgg 8220 aaacttacct gattacagga attgcttggg ttcaggcaga ttcccacttt cacctctaga 8280 gatttagatt cagaaacact ggggtaggcc ctggagagca gtactcttaa caagctcctc 8340 agtgcttctt accattaggc aaattaggga aacactgcat tgggtcaaag tgctgccttt 8400 aatcgaccat tagagggagt tctctaaata acaaagttat tactctaatt caaaatgctt 8460 taaagaattt tccaaggaat acaagccatc tggttggtgt tagttatagc agtgatttca 8520 ttagagtgta catttaacat tttagtttta tcaaaatttt ttgaaattaa gaattagaac 8580 cagagctcct atcagtatat atgtacacag gtgtgcatgc cagtgttcaa aagattgtgt 8640 aaaagttcaa gcccgtttta gaaagccaac attttatgtt ataatatgct gttaatcagg 8700 actttattaa ataaaaacat tggctcttcc aacccccact gccaaa 8746 <210> 10 <211> 1066 <212> DNA <213> C11orf24 <400> 10 agggcgcgct gcccggagct gcctgggttg cgctgccggc cacgtccccg cgccgggcct 60 caggctcctt cctactgtcc gagggccacc aggccgccgg gggcctgctg cgcccggatg 120 cgtctgttac tagagtggag agtctacctt cgtctcacat gtgccacaaa ggatggcatg 180 gcccgggagt gccccaccac gtggctttca ccccctgcaa agccagactt cgcccagcga 240 cacagtgtca agcccacagc tctccaagga ggaagatggt ccaggctggg agcatcccct 300 tagcagcagc ctctgatccc ttggccaagc aggagggaac cattagcagc ctgaggagct 360 ggctggctgg gagcctcggg gaccgcccag ccttgctccc agctcaccca caagatgtgg 420 acagctcttg tgctcatttg gattttctcc ttgtccttat ctgaaagcca tgcggcatcc 480 aacgatccac gcaactttgt ccctaacaaa atgtggaagg gattagtcaa gaggaatgca 540 tctgtggaaa cagttgataa taaaacgtct gaggatgtaa ccatggcagc agcttctcct 600 gtcacattga ccaaagggac ttcggcagcc cacctcaact ctatggaagt cacaacagag 660 gacacaagca ggacagatgc ctatgagagc tacaagaaga aggactacac ccaggtggac 720 tacttaatca acgggatgta tgcggactca gaaatgtgag gggggcgggg gcctggcggg 780 aggcctggcc ccttcctcgt cctttccttt tgcctttgag accaaaccaa gtgcttccaa 840 attcttttgg tgcaattgag gagatatgcc agatgcttaa acacatttaa ttgctgtcag 900 attaattcca tgatcactaa agagttgctg cttttttcat atttattttt gtaaatgatt 960 ctgtgcccag gagcagctgg gggttccacc tcagggtggg gcgggcagga ccccgtctcc 1020 ccaggtgtcg gagcctgacc tgaattaaag tactgactgc tcgcca 1066 <210> 11 <211> 3572 <212> DNA <213> CAMKK1 <400> 11 gctcggcgat ctgggcccca gcgaggcggt ggggcggggc ggggcggggc ggggcgcgca 60 gcaggagcga gtggggccgc ccgccgggcc gcggacactg tcgcccggcg cccaggttcc 120 caacaaggct acgcagaaga acccccttga ctgaagcaat ggaggggggt ccagctgtct 180 gctgccagga tcctcgggca gagctggtag aacgggtggc agccatcgat gtgactcact 240 tggaggaggc agatggtggc ccagagccta ctagaaacgg tgtggacccc ccaccacggg 300 ccagagctgc ctctgtgatc cctggcagta cttcaagact gctcccagcc cggcctagcc 360 tctcagccag gaagctttcc ctacaggagc ggccagcagg aagctatctg gaggcgcagg 420 ctgggcctta tgccacgggg cctgccagcc acatctcccc ccgggcctgg cggaggccca 480 ccatcgagtc ccaccacgtg gccatctcag atgcagagga ctgcgtgcag ctgaaccagt 540 acaagctgca gagtgagatt ggcaagggtg cctacggtgt ggtgaggctg gcctacaacg 600 aaagtgaaga cagacactat gcaatgaaag tcctttccaa aaagaagtta ctgaagcagt 660 atggctttcc acgtcgccct cccccgagag ggtcccaggc tgcccaggga ggaccagcca 720 agcagctgct gcccctggag cgggtgtacc aggagattgc catcctgaag aagctggacc 780 acgtgaatgt ggtcaaactg atcgaggtcc tggatgaccc agctgaggac aacctctatt 840 tggtgtttga cctcctgaga aaggggcccg tcatggaagt gccctgtgac aagcccttct 900 cggaggagca agctcgcctc tacctgcggg acgtcatcct gggcctcgag tacttgcact 960 gccagaagat cgtccacagg gacatcaagc catccaacct gctcctgggg gatgatgggc 1020 acgtgaagat cgccgacttt ggcgtcagca accagtttga ggggaacgac gctcagctgt 1080 ccagcacggc gggaacccca gcattcatgg cccccgaggc catttctgat tccggccaga 1140 gcttcagtgg gaaggccttg gatgtatggg ccactggcgt cacgttgtac tgctttgtct 1200 atgggaagtg cccattcatc gacgatttca tcctggccct ccacaggaag atcaagaatg 1260 agcccgtggt gtttcctgag gagccagaaa tcagcgagga gctcaaggac ctgatcctga 1320 agatgttaga caagaatccc gagacgagaa ttggggtgcc agacatcaag ttgcaccctt 1380 gggtgaccaa gaacggggag gagccccttc cttcggagga ggagcactgc agcgtggtgg 1440 aggtgacaga ggaggaggtt aagaactcag tcaggctcat ccccagctgg accacggtga 1500 tcctggtgaa gtccatgctg aggaagcgtt cctttgggaa cccgtttgag ccccaagcac 1560 ggagggaaga gcgatccatg tctgctccag gaaacctact ggtgaaagaa gggtttggtg 1620 aagggggcaa gagcccagag ctccccggcg tccaggaaga cgaggctgca tcctgagccc 1680 ctgcatgcac ccagggccac ccggcagcac actcatcccg cgcctccaga ggcccacccc 1740 tcatgcaaca gccgcccccg caggcagggg gctggggact gcagccccac tcccgcccct 1800 cccccatcgt gctgcatgac ctccacgcac gcacgtccag ggacagactg gaatgtatgt 1860 catttggggt cttgggggca gggctcccac gaggccatcc tcctcttctt ggacctcctt 1920 ggcctgaccc attctgtggg gaaaccgggt gcccatggag cctcagaaat gccacccggc 1980 tggttggcat ggcctggggc aggaggcaga ggcaggagac caagatggca ggtggaggcc 2040 aggcttacca caacggaaga gacctcccgc tggggccggg caggcctggc tcagctgcca 2100 caggcatatg gtggagaggg gggtaccctg cccaccttgg ggtggtggca ccagagctct 2160 tgtctattca gacgctggta tgggggctcg gacccctcac tggggacagg gccagtgttg 2220 gagaattctg attccttttt tgttgtcttt tacttttgtt tttaacctgg gggttcgggg 2280 agaggccctg cttgggaaca tctcacgagc tttcctacat cttccgtggt tcccagcaca 2340 gcccaagatt atttggcagc caagtggatg gaactaactt tcctggactg tgtttcgcat 2400 tcggcgttat ctggaaagtg gactgaacgg aatcaagctc tgagcagagg cctgaagcgg 2460 aagcaccaca tcgtccctgc ccatctcact ctctcccttg atgatgcccc tagagctgag 2520 gctggagaag acaccagggc tgactttgac cgagggccat ggacgcgaca ggcctgtggc 2580 cctgcgcatg ctgaaataac tggaacccag cctctcctcc tacaccggcc tacccatctg 2640 ggcccaagag ctgcactcac actcctacaa cgaaggacaa actgtccagg tcggagggat 2700 cacgagacac agaacctgga ggggtgtgca cgctggcagg tggcctctgc ggcaattgcc 2760 tcaccctgag gacatcagca gtcagcctgc tcagagcggg ggtgctggag cgcgtgcaga 2820 cacagctctt ccggagcagc cttcaccttc tctctgggat cagtgtccgg ctggccgacg 2880 tggcatttgc tgaccgaatg ctcatagagg ttgaccccca cagggtcacg caggactcgg 2940 acactgccct ggaaacatgg atggacaagg gcttttggcc acaggtgtgg gtgtcctgtt 3000 ggaggagggc ttgtttggag aagggaggct ggctggggga gaaacccgga tcccgctgca 3060 tctccgcgcc tgtgggtgca tgtcgcgtgc tcatctgttg cacacagctc actcgtatgt 3120 cctgcactgg tacatgcatc tgtaatacag tttctacgtc tatttaaggc taggagccga 3180 atgtgcccca ttgtcagtgg gtccacgttt ctccccggct cctctgggct aaggcagtgt 3240 ggcccgaagc ttaaaaagtt actcggtact gtttttaaga acacttttat agagttagtg 3300 gaaggcaagt taagagccaa tcactgatcc ccaagtgttt cttgagcatc tggtctgggg 3360 ggaccacttt gatcggaccc acccttggaa agctcagggg taggcccagg tgggatgctc 3420 accctgtcac tgagggtttt ggttggcatc gttgtttttg aatgtagcac aagcgatgag 3480 caaactctat aagagtgttt taaaaattaa cttcccagga agtgagttaa aaacaataaa 3540 agccctttct tgagttaaaa agaaaaaaaa aa 3572 <210> 12 <211> 1356 <212> DNA <213> CD14 <400> 12 acaagtgtga agcctggaag ccggcgggtg ccgctgtgta ggaaagaagc taaagcactt 60 ccagagcctg tccggagctc agaggttcgg aagacttatc gaccatggag cgcgcgtcct 120 gcttgttgct gctgctgctg ccgctggtgc acgtctctgc gaccacgcca gaaccttgtg 180 agctggacga tgaagatttc cgctgcgtct gcaacttctc cgaacctcag cccgactggt 240 ccgaagcctt ccagtgtgtg tctgcagtag aggtggagat ccatgccggc ggtctcaacc 300 tagagccgtt tctaaagcgc gtcgatgcgg acgccgaccc gcggcagtat gctgacacgg 360 tcaaggctct ccgcgtgcgg cggctcacag tgggagccgc acaggttcct gctcagctac 420 tggtaggcgc cctgcgtgtg ctagcgtact cccgcctcaa ggaactgacg ctcgaggacc 480 taaagataac cggcaccatg cctccgctgc ctctggaagc cacaggactt gcactttcca 540 gcttgcgcct acgcaacgtg tcgtgggcga cagggcgttc ttggctcgcc gagctgcagc 600 agtggctcaa gccaggcctc aaggtactga gcattgccca agcacactcg cctgcctttt 660 cctgcgaaca ggttcgcgcc ttcccggccc ttaccagcct agacctgtct gacaatcctg 720 gactgggcga acgcggactg atggcggctc tctgtcccca caagttcccg gccatccaga 780 atctagcgct gcgcaacaca ggaatggaga cgcccacagg cgtgtgcgcc gcactggcgg 840 cggcaggtgt gcagccccac agcctagacc tcagccacaa ctcgctgcgc gccaccgtaa 900 accctagcgc tccgagatgc atgtggtcca gcgccctgaa ctccctcaat ctgtcgttcg 960 ctgggctgga acaggtgcct aaaggactgc cagccaagct cagagtgctc gatctcagct 1020 gcaacagact gaacagggcg ccgcagcctg acgagctgcc cgaggtggat aacctgacac 1080 tggacgggaa tcccttcctg gtccctggaa ctgccctccc ccacgagggc tcaatgaact 1140 ccggcgtggt cccagcctgt gcacgttcga ccctgtcggt gggggtgtcg ggaaccctgg 1200 tgctgctcca aggggcccgg ggctttgcct aagatccaag acagaataat gaatggactc 1260 aaactgcctt ggcttcaggg gagtcccgtc aggacgttga ggacttttcg accaattcaa 1320 ccctttgccc cacctttatt aaaatcttaa acaacg 1356 <210> 13 <211> 5582 <212> DNA <213> CELF3 <400> 13 ggtttttgtt gaggagagcg cggccggaga gcagagctcc gggacccagg tgaccgggaa 60 agcaggcagc cccagcggcg ggagcagccg gcagcagccc aggcccgggg actggggtgg 120 gggtgggagg ggggctgagg ggaggacctg aaggggggcg gcagggcaaa agggacccct 180 ggagccctgc cgccatcaga gatcaagcat ctggcatcag ggatcttcgg acccagcaga 240 aggatccgcc acaggggagg tgtcctccca gggaagccaa cgagagattc acctgcccca 300 catcaggagt gggcccccct tactgacgct gctggcaacc atagcaggcc ccttaacccc 360 tcagtctcct ccccatcacc ctcctcaggc cctttccccg cctccagctc tcatctcaac 420 tcccagttcc cagccctcta agccctagca cccccggcta ccacctaacc ctccaggtct 480 tggccatact cacccccatc ctgggacatt tgccagatct ctgggaggga gatcgtttgt 540 ttaggcgatg ccccctggtg gcatgacagc gtctgcctag acccctgacc cctagcactc 600 aactccctgg gcctcctttg tgtgaagagc cgcccctctg cttagcagcg tggttggggg 660 ccaaagggaa agccagcccc agctgggccc ccgggcccca ccacttatct ccttgctggg 720 cagctcccct tggcctttgg gcctctccct gctcccctcg gcccctcctc ctgggccgcc 780 tcaatgaagg agccggatgc catcaagctg tttgtggggc agatcccgag gcatctggag 840 gagaaggacc tgaagcccat cttcgaacag tttggtcgga tctttgagct gactgtcatc 900 aaggacaagt acaccgggct gcacaaggga tgtgccttcc tgacatactg tgcccgggat 960 tcagccctga aggcccagag cgccctgcac gaacagaaga cgcttccagg gatgaacagg 1020 ccgatccagg tcaagccagc cgacagcgag agccgaggag aagaccggaa gctctttgtg 1080 gggatgctag ggaagcagca gacagatgag gacgtccgga agatgtttga gcccttcggg 1140 accatcgacg agtgcactgt gctccggggg ccagatggca ccagcaaagg ctgcgccttc 1200 gtgaagttcc agacccacgc tgaggcccag gcggccatca acacccttca cagcagccgg 1260 accctgccag gtgcctcgtc cagcctggtg gtgaagtttg ctgacactga gaaggagcga 1320 ggtctccgcc gcatgcagca ggtggccacc cagttgggca tgttcagccc catcgccctc 1380 cagtttggag cctacagcgc ctacacccag gccctgatgc agcagcaggc ggccctggta 1440 gcggctcaca gtgcctacct cagccccatg gccaccatgg ctgccgtgca gatgcagcac 1500 atggctgcca tcaatgccaa tggcctcatc gccaccccca tcaccccatc ctcaggaacc 1560 agcacccctc ctgccatcgc tgccacgcct gtctctgcca ttccggctgc cctgggcgtc 1620 aacggctaca gcccggtgcc cacccagccc actgggcagc ctgcccctga tgctctgtat 1680 cccaacgggg ttcaccccta cccagcccag agccccgcgg cccccgtgga ccccctgcag 1740 caggcctacg cggggatgca gcactacaca gcagcctacc cagcagccta cagcctggtt 1800 gcacctgcgt tcccgcagcc tccagccctg gtcgcccagc agccccccacc accacctcaa 1860 cagcagcagc agcagcagca gcagcaacag cagcagcagc aaagagaagg ccctgatggc 1920 tgcaacatct tcatctacca cctgccccag gagttcactg actcagagat cctccagatg 1980 tttgtcccct ttggccacgt catctcagcc aaagtctttg ttgaccgagc caccaatcaa 2040 agcaaatgtt ttggctttgt gagtttcgac aatccggcca gtgcccaggc tgccatccag 2100 gccatgaatg gcttccagat cggcatgaag cgcctcaaag tccagctaaa gcggcctaag 2160 gatgccaacc ggccctactg agggccccca ggtctggaga tcccagagga aggggcgcct 2220 cacaccctct tcccacgact ggccccggcc ctctccgcac acctgccctg ggccttgact 2280 gggttctggg gcaaacgctg cttcgtggcc cccgggggca caagacaccg gcccctccca 2340 cccccctgcc tctctgaagg gccatggcta tgcttccctg gctccaaggg cccatttcct 2400 cctagatgcc cttttggcct ttgtgaggga gcgaggaaca ggctcgaagg ctccggggta 2460 tctgccttct gctgggctcc tgtgacaggc cttctgtacc cagcgtttgt acttgcctcc 2520 cccaacagtg ggcctgttct acccgtgcag gccccaggag agccgcaggg gcctgccaca 2580 cactcccagc tcaccctcac cccagcctct tccccacatt aggggtttct tggaagctgg 2640 ctctcactcc cctccaccct cagctagagg taggatatcc ctgattcctg ggctcccagc 2700 cctaaaactc actgcctccc ccaagggccc cctctaagga gggtgtgggg gagccctgag 2760 ggctgcctct ctgccagtca gccacagaga ccctcctcct ttcacgagga aaagaccttc 2820 ccctgaaccc ctaaaaatgt ttacagtctc tgctggttcc ctctgtgtaa ataccactac 2880 cacccgtgcg ttatccagcc cgcccggcct ggcccggacg ctgccatctc tctttctggg 2940 agtttagaca atgttgccct tggatttttt tctctctctt aatttctccc tttgctttgg 3000 ggggtaattg ggtattggga ggaggggtgt ggggaggggt caaggggttt attacctgat 3060 cattttcttt aggaagaggt tttagggaaa agaaaatggg gtgggggtgg gggtggtaag 3120 gggagaccgg gggagtcagtt tcagacagtt ctctatgctt aacttattta tttattgcat 3180 tttactttta aagagttggt cttttctgtc taaataaaga aaaaagttta aaagcatcaa 3240 ataagagtct tggaaggttg agggtagggg attgttccct acccacactg ggaaggggga 3300 gggaggtaga gaatgaggtt tgagagagaa aatcccatca gggaaggccg ggcccttgct 3360 tttgagcagc atccaggcct tgttcatggc ttcatgatcc tgtccttcag cccttctttg 3420 gggcttaatt ctggaatgtc ctgcagagtt cggcacaagg agatctcccc tgtcgggggc 3480 tctcccctgt atccagctct gtccctctga aggctgagga cttgcagtct cacatctgga 3540 cctccatttc tgcacagagg ccagtgtgga tactgggagc cagttgtgac accaccattt 3600 actaaccact gctccatatg tgattctgtt ccaagtcctt attgtgcatt tcctcatttt 3660 acctcctaac aaccttgtga ggcaggctat agtttattta ttttacttat ttactttgaa 3720 acagggtctc actctgtcac tcaagctgga gtgtgatggt gagatcatag ctcactgcaa 3780 ccttgaactc ctggttcagg ggatcctcct gtctcagcct cccaagtagt taggactata 3840 agcggctgca ccaccacgcc cagctcattt ttaaaaatgg tgtttttttt tgtagacagg 3900 gtcttgctat gttgcccagg ctggtctcga acccctgggc tcaagcaaac ctcctgcctt 3960 ggcctcccga agtgctcaga ttacaggcat gagccaccac gcccagccta ggtaggatat 4020 aattttatag atgggaaaag gaggcttgga aggttaacta acttccctgg agtcacaaag 4080 ccagtaaggc atggctgtag gagttgaacc cagtttgtca gattccaaag cccatgatgt 4140 tctcttctta cctgttcttt gacctgaggc aaagatccca agaagtagca agcaggctta 4200 ggagtgagtc cttcaggtag agggtggact gcataagccc taagtccctc cacttcctag 4260 attcttctct gtgagctgct ttagggcagg ctcaggatca cacaggtgtc ttctttgact 4320 tcatagaaca tgtgcttcta ggctgctacc ccaccctctg tcttcatcat tagtaagcag 4380 caccactagg tacctactca agccaaaact tggattacac cctttctctc atgtctcctc 4440 cccaatccaa ctgcaaagcc ctaccaagtc tacctctaaa gtattcagct gatttactta 4500 ctcatgtctc tgcatctcca cagccatcaa cactgtccac gtcacattgc tctcatctgt 4560 ctccatgttt cttttcctgc tctcctacaa tttgttctcc caagaagcca agagtcatct 4620 tttaaaagtt aattcaccaa catttactac ccagtctgct ttgtccagca ctgtatcctg 4680 gtcaccctaa acagtgcccc aaatattaga cattgcttag taaataagaa atgactgttg 4740 gacatctata ctggacttcc catccatatc tacatcatca tagggccaat gctaaaactt 4800 tctcccataa agtcctgact catatatttc tattttctag tcacatagac agaaaacctc 4860 aagagttttt agtactttcg cataaactca atggtattaa atcatttaag atttcacttc 4920 cacaaacttt ctcatatcat ttccctcttt tcaattatca ctgcctacac ttattaactg 4980 agtaatcata gcaatttcct aattggtcct tctgtctatg ttctgaagca tcaatctttc 5040 taaactgcag ctaataaaaa acaaaacttc tctgctgctg ttttttgttg tttttcatag 5100 aacacctcag cctggcattc aaggctcttc gaagccttac tttccacttc attcctacac 5160 atacccaaat agaactattc attgttctct aggcaagttt ggtccctttt ctcccatgtc 5220 ttttcattcc cagttactac agtgtctggc acataacggc tcaataaatg tttgttgaat 5280 gccttcttgt tgaaatcctt ctcacactaa aacagttcac cttaaacact actttcttca 5340 tgaaaatctt aacggccctc atccacaggt ctttctcctt ccttttctag tccttatggc 5400 acttaaacct ttcactgctg tgtatcatgg ccatgcgtaa gtgtctcatt cttctgtgag 5460 cctgtaagct ggcagaaatg tttctttctt tgcttttgtg tctgttgcag tatctcaaac 5520 aatctcccca ccccaccccc aacagcagat acctaataaa tgtttgactt taaccactgt 5580 aa 5582 <210> 14 <211> 3244 <212> DNA <213> CLCN2 <400> 14 gcactctgct ctcggcctcc cgggctgcgg ggacgggacg gctgccggcg cggactttgc 60 gggccgggag ccgagtccag gacagagccg gaaccgccga gggaggcgag agggcagtgc 120 gcggagatgg cggccgcggc ggcggaggaa gggatggagc cacgggcgct gcagtacgag 180 cagaccctga tgtatggccg gtacactcag gaccttgggg cctttgccaa agaggaagct 240 gctcggattc gcctgggagg gcctgaaccc tggaaaggtc ccccttcctc tcgggctgcc 300 ccagagctct tggaatatgg acggagccgt tgcgcccgat gccgcgtctg ttctgtccgc 360 tgccacaagt tcctagtatc cagggttggt gaagattgga tcttcctggt cctgctgggg 420 cttctcatgg cattggtcag ctgggtcatg gactatgcca ttgctgcctg tctgcaagcc 480 cagcagtgga tgtcccgggg cttgaacacc agcatcttgc tccagtacct ggcctgggtc 540 acctaccctg ttgtcctcat cactttctca gccggattca cacagatcct ggcccctcag 600 gctgtcggct ctggcatccc tgagatgaag accatcttgc ggggagtggt gctgaaagaa 660 tacctcacac tcaagacctt tatagctaag gtcattgggc tgacctgcgc cctaggcagc 720 gggatgccgc ttggcaaaga gggccctttt gtgcatatcg caagcatgtg tgctgccctt 780 ctcagcaagt tcctctccct ctttgggggt atctatgaga atgaatcccg gaacacagag 840 atgctggctg ccgcctgtgc cgtgggggtg ggctgctgct tcgcggcacc tattggaggc 900 gtcctcttca gcatcgaggt cacctccacc ttctttgcag tgcggaacta ctggcggggc 960 ttcttcgctg ccaccttcag tgccttcatc ttccgggtct tggcagtctg gaaccgggat 1020 gaagagacta ttacagccct cttcaaaacc cgattccggc tcgacttccc ctttgacctg 1080 caggagctgc cagcctttgc tgtcattggt attgctagtg gcttcggtgg agccctcttt 1140 gtctacctga accggaagat tgtccaggtg atgcggaagc agaaaaccat caatcgcttc 1200 ctcatgagga aacgcctgct cttcccggct ctggtgaccc tgctcatctc cacgctgacc 1260 ttcccccctg gctttggaca gttcatggct ggacagctct cacagaaaga gacgctggtc 1320 accctgtttg acaatcggac gtgggtccgc cagggcctgg tggaggagct agaaccaccc 1380 agcacctcac aggcctggaa cccaccacgt gccaacgtct tcctcaccct ggtcatcttc 1440 attctcatga agttctggat gtctgcactg gccaccacca tcccagttcc ctgtggggcc 1500 ttcatgcctg tctttgtcat tggagcagca tttgggcgtc tggtgggtga aagcatggct 1560 gcctggttcc cagatggaat tcatacggac agcagcacct accggattgt gcctgggggc 1620 tacgctgtgg tcggggcagc tgcgctggca ggagcggtga cacacacagt gtccacggct 1680 gtgatcgtgt tcgagctcac aggccagatt gcccacatcc tgcctgtcat gatcgccgtc 1740 atcctggcca acgctgtcgc ccagagtctg cagccctccc tctatgacag catcatccga 1800 atcaagaaac tgccctacct gcctgagctc ggctggggcc gccaccagca gtaccgggtg 1860 cgtgtggagg acatcatggt gcgggatgtt ccccatgtgg ccctcagctg caccttccgg 1920 gacctgcgtt tggcactgca caggaccaag ggccgaatgc tggccctagt ggagtcccct 1980 gagtccatga ttctgctggg ctccatcgag cgttcacagg tggtggcatt gttgggggcc 2040 cagctgagcc cagcccgccg gcggcagcac atgcaggagc gcagagccac ccagacctct 2100 ccactatctg atcaggaggg tccccctacc cctgaggctt ctgtctgctt ccaggtgaac 2160 acagaagact cagccttccc agcagcccgg ggggagaccc acaagcccct aaagcctgca 2220 ctcaagaggg ggcccagtgt caccaggaac ctcggagaga gtcccacagg gagcgcagag 2280 tcggcaggca tcgccctccg gagcctcttc tgtggcagtc caccccctga ggctgcttcg 2340 gagaagttgg aatcctgtga gaagcgcaag ctgaagcgtg tccgaatctc cctggcaagt 2400 gacgcggacc tggaaggcga gatgagccct gaagagattc tggagtggga ggagcagcaa 2460 ctagatgaac ctgtcaactt cagtgactgc aaaattgatc ctgctccctt ccagctggtg 2520 gagcggacct ctttgcacaa gactcacact atcttctcac tgctgggagt ggaccatgct 2580 tatgtcacca gtattggcag actcattgga atcgttactc taaaggagct ccggaaggcc 2640 atcgagggct ctgtcacagc acagggtgtg aaagtccggc cgcccctcgc cagcttccga 2700 gacagtgcca ccagcagcag tgacacggag accactgagg tgcatgcact ctgggggccc 2760 cactcccgtc atggcctccc ccgggagggc agcccttccg acagcgacga caaatgccaa 2820 tgagcccctc gtgggtggcc taggatggtg ctagccatgc ccgtcagccc agaatgtgca 2880 tctttcattc cttctgcctt cggaaggcag gaggcagcta cagctggagg ctgcacccca 2940 gccccctcca gacctggggt gccagcttct cccagttcat cctacctgga atctgaccca 3000 ctacccacct gcaacaagtc ttccagaggc aggaagatag gccctgccct ggcaggatgg 3060 gttggggtca cttgacccct gctccccctt tgaggggaaa ggggtggaac taagatgggt 3120 ttataactgg aacctccaat gaccagatgt atatagagat ttacaaagat ttttatatta 3180 atttaataaa acaaattctt aaatagaaca aaataaacac ctaatgagcc acttatatat 3240 agaa 3244 <210> 15 <211> 4295 <212> DNA <213> CLIP4 <400> 15 gtccccaccg agtccccagc gcgtgcgcgg ggccgtggcc gaggcctgcg cgccgcccgg 60 ccgcctgcac tgcgcgcgcg cccaccccgc gtgggaggca gcgggagggg cccggagagg 120 tgtggagcgg cgcggcggga ggctccgtgg gcggccacgg gagacagcgc cggcgggagc 180 gcgcctctcg gcctttcctc cgcgccccg cgtccccagc cggccgctcc gagaggaccc 240 ggaggaggtg gctttctaga agatgaccat agaggacctt ccagattttc cattagaagg 300 aaatcctttg tttggaagat acccatttat attttctgct tctgataccc cagttatctt 360 ttccatttct gcagcaccaa tgccttcaga ctgtgaattt tctttctttg atcctaatga 420 tgcatcatgc caggaaattc tttttgatcc caaaacttca gtttcagaat tatttgccat 480 tttgagacag tgggttcctc aggtccaaca aaacattgac attattggaa atgagattct 540 taagagaggt tgcaatgtga atgatagaga tggattgaca gatatgactc ttttacatta 600 tacctgcaaa tctggagctc atggtattgg tgatgtggaa acagctgtaa aatttgcaac 660 tcagcttatt gacctgggag cagacattag tttgcggagt cgctggacaa acatgaatgc 720 tttgcattat gctgcttatt ttgatgtccc tgaacttata agagtgattt tgaaaacatc 780 gaaaccaaaa gatgtggatg ccacttgcag tgattttaat tttggaacag ctttgcatat 840 tgcagcatac aacttgtgtg caggtgctgt gaagtgcctc ttggagcagg gagcaaatcc 900 tgcatttagg aatgacaaag gacagatccc tgctgatgtt gttccagacc cagtagatat 960 gccgttagag atggctgacg ccgcagccac tgctaaggaa atcaagcaga tgcttctaga 1020 tgcggtgcct ctgtcatgta acatctcaaa ggccatgctc ccaaattatg atcatgtcac 1080 tggcaaggca atgcttacgt cacttggcct gaagttgggg gatcgtgttg ttattgcagg 1140 acagaaggtt ggtacattaa gattttgtgg aacaactgaa tttgcaagtg ggcagtgggc 1200 tggcattgaa ctggatgaac cagaaggaaa aaataatgga agtgttggaa aagtccagta 1260 ctttaaatgt gcccccaagt atggtatttt tgcacctctt tcaaagataa gtaaagcaaa 1320 aggtcgaagg aagaatataa cacacactcc ttctacaaaa gctgctgtac ctctcatcag 1380 gtcccagaaa attgacgtag ctcatgtgac gtcaaaagta aatactggat taatgacatc 1440 aaaaaaagat agtgcttctg agtcaacact ttcattgcct cctggtgaag aacttaaaac 1500 tgtgacagag aaagatgttg ccctgcttgg atctgtcagc agctgctcct ctacatcttc 1560 tttggaacac agacagagct accccaagaa acagaatgca atcagcagta acaagaagac 1620 aatgagcaaa agcccttccc tttcatccag agccagtgct ggtttgaatt cctcagcaac 1680 atctacagca aataatagcc gttgcgaggg ggaactccgc ctcggagaga gagtgttagt 1740 ggtaggacag agactgggca ccattaggtt ctttgggaca acaaacttcg ctccaggata 1800 ttggtatggt atagagcttg aaaaacccca tggcaagaat gatggttcag ttggaggtgt 1860 gcagtatttt agctgttctc caagatatgg aatatttgct cccccatcca gggtgcaaag 1920 agtaacagat tccctggata ccctttcaga aatttcttca aataaacaga accattctta 1980 tcctggtttt aggagaagtt ttagcacaac ttctgcttct tcccaaaagg agattaacag 2040 aagaaatgct ttttccaaat cgaaagctgc tttgcgtcgc agttggagca gcacccccac 2100 cgcaggtggc attgaaggga gcgtgaagct gcacgagggg tctcaggtcc tgctcacgag 2160 ctccaatgag atgggtactg ttaggtatgt gggccccact gactttgctt caggtatctg 2220 gcttggactt gagctccgaa gcgccaaggg aaaaaatgat gggtcagtgg gtgacaagcg 2280 ctatttcacc tgtaagccga accatggagt cttagttcga ccgagcagag tgacctatcg 2340 gggaattaat gggtcaaaac ttgtggatga gaattgttaa gcttctaaaa tattaaataa 2400 gctcaaatat atatatttgg tgtaaataaa gagtccatgg taaatggttt actttattta 2460 gccatattaa aattttgaaa atatagttat cttcttaaaa accattataa caattcagag 2520 agagttcttt acaaagccat gaatatgaac tatggggaat catggttctt ttaaagcaat 2580 tttcaaaata agtaccaatt aaagctttag gttccaagaa gattctggga ctcaggaaga 2640 aaaagtgcca tcaggtgacc agctgttgca tttcttgctt attctgtttt gtttttgcac 2700 atcataatgg atttttctta gtgccctaat tgtgaagggt ttctctagct ttggttatgt 2760 gtaatgttca cgtgaccttt ttttgtcaat catttttgga atttttcttt ctttctgtgc 2820 tttattacta ataagtccaa tgagtgagta gtagctagat gactagtatg tagttttata 2880 ttttggtaaa attatttgcc ctttcagaaa tgcctcatct aaagatacat gataattttg 2940 gagttggaag gggccttaga ggctctccag ctctgcttct tgcccattgc caaatactga 3000 aatggaagcc cgtcttacct ggggtcacta actggttggt taactgagct aagaatatagac 3060 tgtgggtctc ctcacttgtg gcccagtgct ctttctgcta tacaaaatgt ctaatctcag 3120 atttttcttc tgctgcttga ctgcttcatc tggatgaact acaaaaaacc catgattaag 3180 gtttatgaat tcaagtaata attagatttt ttttgcacag acttacttaa cttccttatt 3240 ggatatgttt gtaacacata aacacaaagc acttttcaaa catgatgcac ttttatcttt 3300 gtgaataatt tactgtcctt tcctcctggg atatgagaaa cattttaaaa aacgtattta 3360 acagaagaga gcaaataaag atatatcagg aaggatgtat tagttattta cttaaatgtt 3420 tataatatct ggattttttt tgttttgtta ctcatagaac tggtgttgtt tgctgttttt 3480 atttctctaa ttgttgcaga gttctgcctg ttacaaagct acagaactgt attgttttta 3540 ttttccttct tgagcacatg ttaacaaact aagcttcaca ttagagtgat gtcataatgt 3600 aaaatgtttg cattgtggtt aggtattgaa gtttatgtcc tgtctgtgta aagattcatc 3660 ttttattgta aatatttaga ctttaccaca gaaatattgg aacagtttgc tttataagat 3720 taaaaagcat ccttcagaat ggagcttgcc ttgtgcttag aaataatatg ttgaactatt 3780 ttgcaatata ctattttaaa tctaaattct gtcacttcgc tgccttttta aaatagtgtg 3840 gtatttcaaa tattgctaga gctattttcc tgaaatacat ttgcaaaata aggctgcttt 3900 gtaatcaagg aatattttta ttgattgaag gaaatgactg tactgcgatt caaaagtaaa 3960 cttattttat tatacagatt atttcttaaa aactctattt ataccttaac atgaaatcca 4020 tgaccacacc aaacttggtt attcataatt tttcctgtta aatataaaac actgtaagtt 4080 aaaaacagta atgccaacat tgaatttatt tttgaggtca aagaaccagt tgttctcttt 4140 atatttagat gaggatgatt gagtccatat actatgtatg tttacatata ctatacatgc 4200 acattaggtg ttttcatttg tgttttgctt atgaaatgtc atttaaagtt cacttcttga 4260 gcatcaataa aaagggaagc tgtgtggttt tggaa 4295 <210> 16 <211> 6060 <212> DNA <213> CRIM1 <400> 16 aggagtgagg cgagcggggc gcgcggagcg gacgccgcgg atcttgtgct gcgccaccgc 60 gcccactcgg cagctcggga ggcggggacc ggcccggagg ctgcgccgct gcggggccgg 120 ccgactcgga ggaggagagg gaggaggcgc cgccggcccg ggctggagcc gagcgcagca 180 gccaccgccg ccgccgcgcc agaagtttgg gttgaaccgg agctgccggg aggaaacttt 240 tttctttttt ccccctccct cccgggagga ggaggaggag gaggagggga agctgccgcc 300 ggcgccaagg ctcgtgggct cggggtcggc gcggcccgca gaaggggcgg gggcctcgcc 360 ccgcgagggg aggcgcgccc cgggggcccc gagaggggcg gtgaggaccg cgggctgctg 420 gtgcggcggc ggcggcgcgt gtgccccgcg caggggaggg cgcccgcccc gctcccggcc 480 cggctgcgag gaggaggcgg cggcggcgca ggaggatgta cttggtggcg ggggacaggg 540 ggttggccgg ctgcgggcac ctcctggtct cgctgctggg gctgctgctg ctgctggcgc 600 gctccggcac ccgggcgctg gtctgcctgc cctgtgacga gtccaagtgc gaggagccca 660 ggaactgccc ggggagcatc gtgcagggcg tctgcggctg ctgctacacg tgcgccagcc 720 agaggaacga gagctgcggc ggcaccttcg ggatttacgg aacctgcgac cgggggctgc 780 gttgtgtcat ccgccccccg ctcaatggcg actccctcac cgagtacgaa gcgggcgttt 840 gcgaagatga gaactggact gatgaccaac tgcttggttt taaaccatgc aatgaaaacc 900 ttattgctgg ctgcaatata atcaatggga aatgtgaatg taacaccatt cgaacctgca 960 gcaatccctt tgagtttcca agtcaggata tgtgcctttc agctttaaag agaattgaag 1020 aagagaagcc agattgctcc aaggcccgct gtgaagtcca gttctctcca cgttgtcctg 1080 aagattctgt tctgatcgag ggttatgctc ctcctgggga gtgctgtccc ttacccagcc 1140 gctgcgtgtg caaccccgca ggctgtctgc gcaaagtctg ccagccggga aacctgaaca 1200 tactagtgtc aaaagcctca gggaagccgg gagagtgctg tgacctctat gagtgcaaac 1260 cagttttcgg cgtggactgc aggactgtgg aatgccctcc tgttcagcag accgcgtgtc 1320 ccccggacag ctatgaaact caagtcagac taactgcaga tggttgctgt actttgccaa 1380 caagatgcga gtgtctctct ggcttatgtg gtttccccgt gtgtgaggtg ggatccactc 1440 cccgcatagt ctctcgtggc gatgggacac ctggaaagtg ctgtgatgtc tttgaatgtg 1500 ttaatgatac aaagccagcc tgcgtattta acaatgtgga atattatgat ggagacatgt 1560 ttcgaatgga caactgtcgg ttctgtcgat gccaaggggg cgttgccatc tgcttcaccg 1620 cccagtgtgg tgagataaac tgcgagaggt actacgtgcc cgaaggagag tgctgcccag 1680 tgtgtgaaga tccagtgtat ccttttaata atcccgctgg ctgctatgcc aatggcctga 1740 tccttgccca cggagaccgg tggcgggaag acgactgcac attctgccag tgcgtcaacg 1800 gtgaacgcca ctgcgttgcg accgtctgcg gacagacctg cacaaaccct gtgaaagtgc 1860 ctggggagtg ttgccctgtg tgcgaagaac caaccatcat cacagttgat ccacctgcat 1920 gtggggagtt atcaaactgc actctgacag ggaaggactg cattaatggt ttcaaacgcg 1980 atcacaatgg ttgtcggacc tgtcagtgca taaacaccga ggaactatgt tcagaacgta 2040 aacaaggctg caccttgaac tgtcccttcg gtttccttac tgatgcccaa aactgtgaga 2100 tctgtgagtg ccgcccaagg cccaagaagt gcagacccat aatctgtgac aagtattgtc 2160 cacttggatt gctgaagaat aagcacggct gtgacatctg tcgctgtaag aaatgtccag 2220 agctctcatg cagtaagatc tgccccttgg gtttccagca ggacagtcac ggctgtctta 2280 tctgcaagtg cagagaggcc tctgcttcag ctgggccacc catcctgtcg ggcacttgtc 2340 tcaccgtgga tggtcatcat cataaaaatg aggagagctg gcacgatggg tgccgggaat 2400 gctactgtct caatggacgg gaaatgtgtg ccctgatcac ctgcccggtg cctgcctgtg 2460 gcaaccccac cattcaccct ggacagtgct gcccatcatg tgcagatgac tttgtggtgc 2520 agaagccaga gctcagtact ccctccattt gccacgcccc tggaggagaa tactttgtgg 2580 aaggagaaac gtggaacatt gactcctgta ctcagtgcac ctgccacagc ggacgggtgc 2640 tgtgtgagac agaggtgtgc ccaccgctgc tctgccagaa cccctcacgc acccaggatt 2700 cctgctgccc acagtgtaca gatcaacctt ttcggccttc cttgtcccgc aataacagcg 2760 tacctaatta ctgcaaaaat gatgaagggg atatattcct ggcagctgag tcctggaagc 2820 ctgacgtttg taccagctgc atctgcattg atagcgtaat tagctgtttc tctgagtcct 2880 gcccttctgt atcctgtgaa agacctgtct tgagaaaagg ccagtgttgt ccctactgca 2940 tagaagacac aattccaaag aaggtggtgt gccacttcag tgggaaggcc tatgccgacg 3000 aggagcggtg ggaccttgac agctgcaccc actgctactg cctgcagggc cagaccctct 3060 gctcgaccgt cagctgcccc cctctgccct gtgttgagcc catcaacgtg gaaggaagtt 3120 gctgcccaat gtgtccagaa atgtatgtcc cagaaccaac caatataccc attgagaaga 3180 caaaccatcg aggagaggtt gacctggagg ttcccctgtg gcccacgcct agtgaaaatg 3240 atatcgtcca tctccctaga gatatgggtc acctccaggt agattacaga gataacaggc 3300 tgcacccaag tgaagattct tcactggact ccattgcctc agttgtggtt cccataatta 3360 tatgcctctc tattataata gcattcctat tcatcaatca gaagaaacag tggataccac 3420 tgctttgctg gtatcgaaca ccaactaagc cttcttcctt aaataatcag ctagtatctg 3480 tggactgcaa gaaaggaacc agagtccagg tggacagttc ccagagaatg ctaagaattg 3540 cagaaccaga tgcaagattc agtggcttct acagcatgca aaaacagaac catctacagg 3600 cagacaattt ctaccaaaca gtgtgaagaa aggcaactag gatgaggttt caaaagacgg 3660 aagacgacta aatctgctct aaaaagtaaa ctagaatttg tgcacttgct tagtggattg 3720 tattggattg tgacttgatg tacagcgcta agaccttact gggatgggct ctgtctacag 3780 caatgtgcag aacaagcatt cccacttttc ctcaagataa ctgaccaagt gttttcttag 3840 aaccaaagtt tttaaagttg ctaagatata tttgcctgta agatagctgt agagatattt 3900 ggggtgggga cagtgagttt ggatggggaa atgggtggga gggtggtgtt gggaagaaaa 3960 attggtcagc ttggctcggg gagaaacctg gtaacataaa agcagttcag tggcccagag 4020 gttatttttt tcctattgct ctgaagactg cactggttgc tgcaaagctc aggcctgaat 4080 gagcaggaaa caaaaaaggc cttgcgaccc agctgccata accaccttag aactaccaga 4140 cgagcacatc agaacccttt gacagccatc ccaggtctaa agccacaagt ttcttttcta 4200 tacagtcaca actgcagtag gcagtgagga agccagagaa atgcgatagc ggcatttctc 4260 taaagcgggt tattaaggat atatacagtt acactttttg ctgcttttat tttcttccaa 4320 gccaatcaat cagccagttc ctagcagagt cagcacatga acaagatcta agtcatttct 4380 tgatgtgagc actggagctt tttttttttt acaacgtgac aggaagagga gggagagggt 4440 gacgaacacc aggcatttcc aggggctata tttcactgtt tgttgttgct ttgttctgtt 4500 atattgttgg ttgttcatag tttttgttga agctctagct taagaagaaa ctttttttaa 4560 aaagactgtt tggggattct ttttccttat tatatactga ttctacaaaa tagaaactac 4620 ttcattttaa ttgtatatta ttcaagcacc tttgttgaag ctcaaaaaaa atgatgcctc 4680 tttaaacttt agcaattata ggagtattta tgtaactatc ttatgcttca aaaaacaaaa 4740 gtatttgtgt gcatgtgtat ataatatata tatatacata tatatttata cacatacaat 4800 ttatgttttc ctgttgaatg tatttttatg agattttaac cagaacaaag gcagataaac 4860 aggcattcca tagcagtgct tttgatcact tacaaatttt ttgaataaca caaaatctca 4920 ttctacctgc agtttaattg gaaagatgtg tgtgtgagag tatgtatgtg tgtgtgtgtg 4980 tgtgtgtgtg tgcgcgcgca cgcacgcctt gagcagtcag cattgcacct gctatggaga 5040 agggtattcc tttattaaaa tcttcctcat ttggatttgc tttcagttgg ttttcaattt 5100 gctcactggc cagagacatt gatggcagtt cttatctgca tcactaatca gctcctggat 5160 tttttttttt tttttttcaa acaatggttt gaaacaacta ctggaatatt gtccacaata 5220 agctggaagt ttgttgtagt atgcctcaaa tataactgac tgtatactat agtggtaact 5280 tttcaaacag cccttagcac ttttatacta attaacccat ttgtgcattg agttttcttt 5340 taaaaatgct tgttgtgaaa gacacagata cccagtatgc ttaacgtgaa aagaaaatgt 5400 gttctgtttt gtaaaggaac tttcaagtat tgttgtaaat acttggacag aggttgctga 5460 actttaaaaa aaattaattt attattataa tgacctaatt tattaatctg aagattaacc 5520 atttttttgt cttagaatat caaaaagaaa aagaaaaagg tgttctagct gtttgcatca 5580 aaggaaaaaa agatttatta tcaaggggca atatttttat cttttccaaa ataaatttgt 5640 taatgataca ttacaaaaat agattgacat cagcctgatt agtataaatt ttgttggtaa 5700 ttaatccatt cctggcataa aaagtcttta tcaaaaaaaa ttgtagatgc ttgctttttg 5760 ttttttcaat catggccata ttatgaaaat actaacagga tataggacaa ggtgtaaatt 5820 tttttattat tattttaaag atatgattta tcctgagtgc tgtatctatt actcttttac 5880 tttggttcct gttgtgctct tgtaaaagaa aaatataatt tcctgaagaa taaaatagat 5940 atatggcact tggagtgcat catagttcta cagtttgttt ttgttttctt caaaaaagct 6000 gtaagagaat tatctgcaac ttgattcttg gcaggaaata aacattttga gttgaaatca 6060 6060 <210> 17 <211> 2301 <212> DNA <213> CXorf56 <400> 17 atttcggggc gaccctcttc ttggcgtaga gttttcagat tgctcttggg aatcatgccg 60 aaagtagtgt ctcggtcagt agtctgctct gacactcggg accgggagga atatgacgac 120 ggcgagaagc ccctccatgt ttactactgt ttgtgcggcc agatggtcct agtgctggac 180 tgccagttag agaaattgcc catgaggccc cgggaccggt cccgtgtgat tgatgctgcc 240 aaacatgccc ataagttttg taacacagaa gatgaggaga ctatgtatct gcggagacct 300 gaaggcattg aacgacagta caggaagaaa tgtgcaaagt gtggactgcc gctcttctac 360 caatcccagc caaagaatgc tcctgttacc ttcattgtgg atggagcagt agtcaagttt 420 ggccagggct ttgggaaaac gaacatatat actcagaaac aagagcctcc taagaaggtg 480 atgatgacca aacggaccaa agacatgggc aagttcagtt ctgtcaccgt gtctaccatt 540 gatgaagagg aagaggagat tgaggctagg gaagttgctg actcatatgc acagaatgcc 600 aaagtgattg aaaaacagct ggagcgcaaa ggcatgagca agaggcgact gcaagagctg 660 gctgaattgg aagccaagaa agcgaaaatg aaggggacct tgattgacaa ccagttcaaa 720 taaccaggcc tttttctaag ccctagacta gaggcaagca tttagatcag gaggcaaagt 780 aatttcttga ttacatagac ggattcctat ttatgcccta gcagaaggct ttacgttgtt 840 tcccattgat tctcctacat tcagtgaggt ctttaactga gtccatttaa cttgctttct 900 tttttttttt tttttttttg agataaagtc ttgctctttc gcccaggatg gagtgcagtg 960 gtgcgatctc ggctcactgc aacctccgcc tcccgggttc aagcagttct cctgcctcag 1020 cctcctgagt agctgggatt acaggcatgt gccaccacgc ctggctaatt tttgtatttt 1080 tagtagagac gggttccacc atgttggcca ggctggtctc caactcctga cctcaaatga 1140 tccacccacc taggcctccc aaagtgctgg gattacagga gtgagccacc gtgcccagcc 1200 ttgccctgct ttctaggaga tggagttttc tgaatttttc tgtatttagg ttttctgtac 1260 tattttttgt ccacttgatg caaacttctt cagctgtgta gaaactttat gaatagatga 1320 gtgcttgagt gtctccagtc tctaaagtgg ctgcttttat tctttcttca aagttaataa 1380 catgttgcaa gatttttgga caaaatatta tggtgtgtca taggaaaagc accatgaatt 1440 atatttaggt atagcaagtc agatcctttg aagtgactct gtctctgttc ttagaagggt 1500 tcttggaatt ggctgtggtt tgaatctttc tactgtcaga ggagacccat taaaagccag 1560 aatctgcata aagctttctt tacttcaaac actgaagctg taggcgagcc atcccgtatc 1620 gactttatac tcaaagaagg aaaagccaga ttgcagtgag tgggtaggac agctcagatc 1680 caaatgaaag tagggtctca agtaacccaa gggtggccgg gtacggtggc tcacgcctgt 1740 aatcctagca gtttgggagg cagaggcggg cagattgcct gagctcagga gtttgagacc 1800 agcctgggca acatggtgaa accctgtctc tactaaaata caaaagaaat tagccaggtg 1860 tggcggcata cccctgtagt cacggctact tgggaggcag aggcaggaga attgcttgaa 1920 ctcgggaggt ggaggttgca gtgagctgag attgcaccac tgtactccag cactccagcc 1980 tgggcgacag agtgagactc tgtctctaca aaaaaaaaaa aaaaaaaaag taacccaagg 2040 gagggagcta ccctctagtc gggcagctga tactgcttcc ttgcatggat acatgggagg 2100 gagacgttat agattaagaa atgatagcaa gataaacaaa atgatttgtt gggtatcttt 2160 tactttacat ttgttatttg cagaggagtg ttgtatatat agatgttatt ttatgtcaca 2220 ctgcttcaat gatacctata tccatgtgtt tgtatccatg tttttatcca ttcaactgta 2280 ttaaaaggtg ttgggacagg a 2301 <210> 18 <211> 2973 <212> DNA <213> CYP4F11 <400> 18 gaggcaaaga cctcctagca gagggggaga ggagggatgc cgcagctgag cctgtcctgg 60 ctgggcctcg ggcccgtggc agcatccccg tggctgcttc tgctgctggt tgggggctcc 120 tggctcctgg cccgcgtcct ggcctggacc tacaccttct atgacaactg ccgccgcctc 180 cagtgttttc ctcaaccccc gaaacagaac tggttttggg gacaccaggg cctggtcact 240 cccacggaag agggcatgaa gacattgacc cagctggtga ccacatatcc ccagggcttt 300 aagttgtggc tgggtcctac cttccccctc ctcattttat gccaccctga cattatccgg 360 cctatcacca gtgcctcagc tgctgtcgca cccaaggata tgattttcta tggcttcctg 420 aagccctggc tgggggatgg gctcctgctg agtggtggtg acaagtggag ccgccaccgt 480 cggatgttga cgcctgcctt ccatttcaac atcttgaagc cttatatgaa gattttcaac 540 aagagtgtga acatcatgca cgacaagtgg cagcgcctgg cctcagaggg cagcgccaga 600 ctggacatgt ttgaacacat cagcctcatg accttggaca gtctgcagaa atgtgtcttc 660 agctttgaaa gcaattgtca ggagaagccc agtgaatata ttgccgccat cttggagctc 720 agtgcctttg tagaaaagag aaaccagcag attctcttgc acacggactt cctgtattat 780 ctcactcctg atgggcagcg cttccgcagg gcctgccacc tggtgcacga cttcacagat 840 gccgtcatcc aggagcggcg ctgcaccctc cccactcagg gtattgatga tttcctcaag 900 aacaaggcaa agtccaagac tttagacttc attgatgtgc ttctgctgag caaggatgaa 960 gatgggaagg aattgtctga tgaggacata agagcagaag ctgacacctt catgtttgag 1020 ggccatgaca ctacagccag tggtctctcc tgggtcctat accaccttgc aaagcaccca 1080 gaataccagg aacagtgccg gcaagaagtg caagagcttc tgaaggaccg tgaacctata 1140 gagattgaat gggacgacct ggcccagctg cccttcctga ccatgtgcat taaggagagc 1200 ctgcggttgc atcccccagt cccggtcatc tcccgatgtt gcacgcagga ctttgtgctc 1260 ccagacggcc gcgtcatccc caaaggcatt gtctgcctca tcaatattat cgggatccat 1320 tacaacccaa ctgtgtggcc agaccctgag gtctacgacc ccttccgttt cgaccaagag 1380 aacatcaagg agaggtcacc tctggctttt attcccttct cggcagggcc cagaaactgc 1440 atcgggcagg cgttcgccat ggctgagatg aaggtggtcc tggcgctcac cctgctgcac 1500 ttccgcatcc tgccgaccca cactgaaccc cgcaggaaac ccgagctgat attgcgcgca 1560 gagggtggac tttggctgcg ggtggagccc ctgggtgcga actcacagtg actgtcctac 1620 ccacccaccc acctctgtag agtcccagaa acaaaactat gctgacacct ctgcttgagc 1680 ctcgttgaca gccagcatgg ggctcctggg gactggtggg atctaagaaa gggaggtgag 1740 tgggtggagg cagggtgacg tctctgaacc caaaaccctg acggcctctc tggctgagca 1800 cagggcatct aggcccttag tgggttctcc cagagcccaa gtaaaaactt tatcctgtgg 1860 gcagtaggga gccctgggag gtgtttgagc aggagaggga acaggattaa gaatgggttt 1920 aaggagcaag actgagactc tgattcagcg agaaacaacc ataggggcag atcccttcat 1980 ctgtcctggg aatgtcctcc caagactgga gtcctcagct cagaacaaag ggaaaggggt 2040 gcagcttcca ccctggcagg ctctcagaaa tttttagttc ctttttccac caacttccca 2100 cccctgtttc tccccctccc agtgcgttct ctctgtgact ctcttccctt actttcagag 2160 gcataggatc tggagccaga ctgcttgggc tcaagtcctg gctctgctgc gtgacttgag 2220 caagttaatt cctctctctg tgcctcggtt ccctcaacca tataatggag acaacagcat 2280 tacctatatc agggttttcc tgaggtctca atataaggga ctcagagctg tgcctggcac 2340 acaatgaatg ctaaatatat ggagccatta ttatttcctg tctcagaaag tctggctgtt 2400 aaagaatgtt gtctttcaag atcgttattt ctaccacgac tttaaaggct gtgttttgga 2460 actcaaaggc aaaaattcta atatctgtgc tccttgaaca acctcttctc ctagagggct 2520 gtgcatataa gatatgtata tatatata tattatatat atatatatat acacacacac 2580 acacacacac acacacatat atacatatac acacacacac acacacacac acacacacac 2640 acacatatat atatatatat attttttttt ttttcctgag gatggtgaag gtacctgact 2700 gtgtgaggtg gtaggagaat gagagaaacc tcagtcagtg tctcaaaata aaatcctgct 2760 acaaacattg atctcttttc atagcctaag ggatgttgca tcgctaaacc ctgttgactt 2820 ctctaatctc ttctgtagct gatctccttc ccttgctaca ctcggttact ctggccttga 2880 ttctgatctc caaatacatt atatttttta tttgggacca tcgtattgcc tttgcacctt 2940 tatcaaatat aagttgccta tatttatttg gat 2973 <210> 19 <211> 2051 <212> DNA <213> DYTN <400> 19 ttgccttttt gttcccctgt cctcattcct ctgctgcaaa accttctgct taaaatactg 60 gttcatttct agttacaggg acccacttgc catctgtcat tccaggaaat ttgtgaaatg 120 gatccagata aacaagatgc tcttaatagt attgagaatt ccatttatag aacaagccttc 180 aaattacaat cagtgcaaac tctgtgccag ttggacttga ttgacagctc cctgattcag 240 caggtcctac tgcgtccaag tttctgggaa gctcgcaagc actccctttc tgtgcagcaa 300 ctttctcagg cactccaaga gctgtttcag aaggccaggg aggaaaaccc aggacaagtg 360 catcccagag ctccggaact cactctgagc cttctcacga caatgtacaa cagcaaagga 420 acaggttttc tccagcttat gcctgcggcc gctgccctaa taaccctctc aggagacagc 480 cctctttcaa aataccgagc tctttttcaa ctctatgcag aaaatagcag gggaggctat 540 gattctgggc cacgcatgac tcgaagggtt ttgagaaaac tactaacaga tctacagcag 600 atcccaactt tcgtgggaga gagtcgtgct ctgtgccctg tggaaagtgc cacccgcagc 660 tgtttccaag gggtgttgag cccagcaatc aaagaagaaa aattcctgtc ttgggtccaa 720 tctgagcctc ccatcctcct gtggctcccg acctgccacc ggttatcagc tgctgaaagg 780 gtcactcacc ctgctcggtg cactctctgc aggactttcc caatcagggg actcagatac 840 cgctgtctga agtgtctcaa ctttgacatc tgccagatgt gtttcttatc tggtcttcac 900 agcaagtccc atcagaagtc tcatcctgtc attgagcact gcattcagat gtcagcaatg 960 cagaatacaa aacttctctt caggaccctc agaaacaacc ttcttcaggg gcgctgtagg 1020 aagaaagaag cagcgagaag gcagcagctg ctggaccagg tgaatccaaa gggtgtgcct 1080 caccatgcgc aggccaggct ccttaaaaaa cagttaaacc aatacaaaga caagttgcaa 1140 gctatataca cctcccagga agaaagaatt tgtcgatttg aaacaaggat tcacaaactc 1200 aaaaccaacc aggatagtct atggaccaag ctacaacaga taagacggga cctacaggca 1260 aggttgcagc cacccggtcc ttcatcttct tcctttcaaa atgtggggaa caaggttgac 1320 cattcttcaa ctgaaaaggt tccaaaggga ggggattatt tgcagatcaa gaatgccact 1380 gaagatgctt caacagggga acctcttcct aagcttgatg aggttgacag aagtcacaga 1440 agtcacacaa atgcagagca tgctctgcga aatccagaat caccagagac cactttgcac 1500 agcaccaggg cacaaagcca aacacaaaag atgccacaga aagtcattag tgccctaccc 1560 agttatcagg agggactgaa gcaggacatc cccaaaatgg ttcctgctga aatgagcagt 1620 cctgctctgg cagccgtgga aaagaaagag gcaggtaaca tcaaggagag aaaggatgag 1680 ctggaggaag aggaactgca agaactattg tcaaaactta tggatgcctt caatctagaa 1740 acgccatcag gcccggagtc ttcagtaaac atggacctgt acagtggagc tcagcgagtg 1800 tgcagggcct tctctgccct tgttgatcaa attgccttgc ccaatttgaa gtgaaatgga 1860 gtccaggctc aaaggcctct tggtgtgatg acaaaatgca gttgcacaac tgtattaaaa 1920 gaattaagac ttctaccttt cttttaatag tttagtgtga actatgaaga aaacaggttt 1980 tgttttttga tctccctccc tacttatgta tcttagttct gcagttcaga gtgaaggttg 2040 ggggttagca g 2051 <210> 20 <211> 10298 <212> DNA <213> FIGNL1 <400> 20 gtcagtcccc gcgcttttcg gaggctgcca gcgtcccaca ccagccgcag gtgaaaaccg 60 gcagaaagac attaagagat tttcctgcag tcactgctgg cagatgatag agccaggatt 120 tgaaagcagg cagcctggct ccagaccctg tgctcttaac tcccgttttg catcaagaac 180 agaatcctat gaaaggcttg cacagtgctt ggtactgaga tagcagcatc aaggagcatt 240 gtgtacatgc agaagtgcac agtacctgga gtgaaactgc ttgtgttcga tttctgatac 300 cattcataac tggctgtgtg atctcaaaac ctctaaaatg cagacctcca gctctagatc 360 tgtgcacctg agtgaatggc agaagaatta cttcgcaatt acatctggca tatgtaccgg 420 accgaaggca gatgcatacc gtgcacagat attacgcatt cagtatgcat gggcaaactc 480 tgagatttcc caggtctgtg ctaccaaact gttcaaaaaa tatgcagaga aatattctgc 540 aattattgat tctgacaatg ttgaatctgg gttgaataat tatgcagaaa acattttaac 600 tttggcagga tctcaacaaa cagatagtga caagtggcag tctggattgt caataaataa 660 tgttttcaaa atgagtagtg tacagaagat gatgcaagct ggcaaaaaat tcaaagactc 720 tctgttggaa cctgctcttg catcagtggt aatccataag gaggccactg tctttgatct 780 tcctaaattt agtgtttgtg gtagttctca agagagtgac tcattaccta actcagctca 840 tgatcgagac cggacccaag acttcccgga gagcaatcgt ttgaaactcc ttcagaatgc 900 ccagccacct atggtgacta acactgctag gacttgtcct acatctcag cacctgtagg 960 tgagtcagct actgcaaaat tccatgtcac accattgttt ggaaatgtca aaaaggaaaa 1020 tcacagctct gcaaaagaaa acataggact taatgtgttc ttatctaacc agtcttgttt 1080 tcctgctgcc tgtgaaaatc cacagaggaa gtctttttat ggttctggca ccattgatgc 1140 actttccaat ccaatactga ataaggcttg tagtaaaaca gaagataatg gcccaaagga 1200 ggatagcagc ctgcctacat ttaaaactgc aaaagaacaa ttatgggtag atcagcaaaa 1260 aaagtaccac caacctcagc gtgcatcagg gtcttcatat ggtggtgtaa aaaagtctct 1320 aggagctagt agatcccgag ggatacttgg aaagtttgtt cctcctatac ccaagcaaga 1380 tggggggagag cagaatggag gaatgcaatg taagccttat ggggcaggac ctacagaacc 1440 agcacatcca gttgatgagc gtctgaagaa cttggagcca aagatgattg aacttattat 1500 gaatgagatt atggatcatg gacctccagt aaattgggaa gatattgcag gagtagaatt 1560 tgctaaagcc accataaagg aaatagttgt gtggcccatg ttgaggccag acatctttac 1620 tggtttaagg ggacccccta aaggaatttt gctctttggt cctcctggga ctggtaaaac 1680 tctaattggc aagtgcattg ctagtcagtc tggggcaaca ttctttagca tctctgcttc 1740 atccttaact tctaaatggg taggtgaggg ggagaaaatg gtccgtgcat tgtttgctgt 1800 tgcaaggtgt cagcaaccag ctgtgatatt tattgacgaa attgattcct tgttatctca 1860 acggggagat ggtgagcatg aatcttctag aaggataaaa acagaatttt tagttcaatt 1920 agatggagca acaacatctt ctgaagatcg tatcctagtg gtgggagcaa caaatcggcc 1980 acaagaaatt gatgaggctg cccggagaag attggtgaaa aggctttata ttcccctccc 2040 agaagcttca gccaggaaac agatagtaat taatctaatg tccaaagagc agtgttgcct 2100 cagtgaagaa gaaattgaac agattgtaca gcagtctgat gcgttttcag gagcagacat 2160 gacacagctt tgcagggagg cttctcttgg tcctattcgc agtttacaaa ctgctgacat 2220 tgctaccata acaccggatc aagttcgacc catagcttac attgattttg aaaatgcttt 2280 tagaactgtg cgacctagtg tttctccaaa agatttagag ctttatgaaa actggaacaa 2340 aacttttggt tgtggaaagt aagtgggata cttggaatca aggcatctct gtagtacagt 2400 cttctttatt ttttagcata gaaagttggg gatgtgttaa ttgtattttt aagaatatat 2460 tctaagttct gtacttcaaa taatagcaca gattttacat ctgattgaca tagtgtatgt 2520 taatgtaagt tttgctttcc agtgattacc tgatacgtaa gcctatttga acaaagtgag 2580 aatgaacttt tgtttctaag aagtctttat cttgaagcta tataacatga aaagtgagct 2640 caaatttttt ttagttgaag attacatata aagttgtgtc tgattaatat tcatctttta 2700 ttgaagaaag tgccttctga tggccacata attcttaatg tcagctagta taatggttta 2760 catttggaca aagtattgct tagtgttatt taagtagatt taagatctca aagctaaagt 2820 gccaattttt actttcttca gccaatttgt tacctctttt atggttttta atttttatca 2880 ggactaacat tttcagaaat agcaaggtgt gatctagtat tagattcaca gaactgaaag 2940 gttaattaag aatgttggtt attttcacgg gagcgtgtga tatttaacat taatatttta 3000 tttgacacta cagcctgtaa tactgctctc tttcaaaaac aagttttcag atttttataa 3060 cagacccatt ttgttttatg aaacatgttc attacagaaa catgagaaaa tagagataag 3120 taaaaagaat aaaagtcact attatcctac cactttgcgg gacacactat taatatttaa 3180 gcatagattc ttccagatgt tttgttttat acagcagtag gattgtgtaa tgtattctct 3240 cttgtagcct attcttcaaa gcgtatcttc actttccatg ttaacataaa tgtcctttta 3300 tgattgtcta ggattccatg gatggatgga atataattga gtcatctggt agagcgcata 3360 taggacagga cgctaggttg tttatctttt gtttattgta aaggaactat gtgggatgca 3420 tttggtgatc tttttaaaaa atgtataaat ttcttgagta attcctggat taaagaatat 3480 gcacttttta aagcttttgg cttgcattct aaattgtcct cttgaaaaag tagttcctgt 3540 gtaaaactcc atctgcactg aatcagagct atggcagcat tgggcagtag gcagttttgg 3600 tatttgttgg cattcttttt gcatttattc aaaaaactga aggtagtgaa cgtagagcaa 3660 tgaacaacac aaatatcctt ggtctcgtgg aggttatatt taagttctaa tgttttctct 3720 tgtgaacagt gcaatttgaa atgacaaatt gaaacacttt tagttgttga atttagacag 3780 tttgtgtata tagtttaaat ttttattctt ggtttgcctt ctgtttttat gttaaaagat 3840 tgttgcaatt tttagttttt ccctttgtaa tatgtgattg tctttcatta gaattcattt 3900 tttgttttgt tttggttatt ttgaaacagt ctcgctgtgt tgcctaggct ggagtgcagt 3960 ggtgtgatct cagctcactg caacctctgc ctcctgggtt ccagtgattc ttgtgcctca 4020 gtctcccttg tagctgagac cacaggtttg caccaccaca cccagctaat ttttgtattt 4080 ttaatcgaga tggggtttca ccatgttgcc caggctgctc tcgaactcct ggcctcaaac 4140 gatccaccca cctcagcctc ctgaagtgtt gggattacag gcatgagcca ccacgcctgg 4200 ccttttttat tagaatttgg acgttaaact tcttgtcttc agttcttagt tatatctttt 4260 aacatcctaa aacattccac aatattcatt actgtcttta tccctttcta tttctatata 4320 aacagcacta taaacttggt ttctttggta ttgatgtcaa ggaattctct agtttttctt 4380 tcttggtgtt taattgcaga tcactcccac cttcttgggt ctagctattt agatttatca 4440 gcatttgccc tctagctgtt aatgttttat ttagctctga aatttggtct taatatttat 4500 tatcagtttt tttcagttac agcttctgcc agccctgact ttaagctccc ttgatcacca 4560 gccacagggc cacttctttc tatggagttt agaaattgtg acaaggagag aaagtctagt 4620 tggtttagct catcttggat taagcagagc ccatgtctct cttgttagct caagaaatgg 4680 tctttcctga attaaggtct actctgttaa ataagaatct aaacctgaaa ggaatagtca 4740 ggatatttta aagctggaaa gaaaatttga gctggggagt caactgttgt ttctacgtta 4800 taccacagag aagctttctt tgtctcaaca ctttgtgatt ttgagtgttt ctgaagcagt 4860 tggataggaa gcttactgaa actttaagat tgcttactct cgccacatgc gattgtcttc 4920 atcgaatata ataatcttgg attaaattat ctcaagtgtg gcactgccct gtctttagct 4980 attgtttcag aaacatgaat gctagcctga tatttaatgt cttcaaaaat tacattccct 5040 tagtagaaat acacatttta ctaaacatgt cacttggtta tggtattaat gcttaacaat 5100 tttgatatga atatggtaat tctaatttat gatttcaggc cttcttaaat ctttattata 5160 catctaataa taatatatga tccttttgat atgtattcat tctgtggtaa atttctaatt 5220 ttctgaaatt ttaactcatt ttctcaattc taaaatatct ctcaggtgtg cctttcatat 5280 tgacaagctg gtcttaatgg aatcatagtc taaagatcat gggctgtgga gccaaataga 5340 cctgttgaat tctggctctg tcatttactg gtgactgttg gttacttaat tattcaatct 5400 caattctaaa gtgagaatag tttatacctg tcttgttgga gagtgaggat taaatagtaa 5460 aatacagatt taaaaggcct ggttcatgtt ttatgattgt gcctcttctt tgaatctgcc 5520 ttgattttgc tcttgttgct gtgaaggatc ttttcagcta ttttgtgtgg ttgtcctagc 5580 tcattctgct tagtgtttgt ggtatttgca tcatattatt agagatcata tgccatctat 5640 ctttagtttt gtggaaaaat tctaattcca aagaaatatc tcttagttat gtttctcctt 5700 ttctacactt tagaactttt ttaaaggtct gtcccagatt attatttttc tctactcatg 5760 cttatatgtt atttattggt ctccattttt actctcccag tgttttttta agggacactt 5820 tacagcccac ctttagggat ctgattaaaa gaaaggattc tatcaaggtc catggcaaaa 5880 ggacaggttg gataaagata acatcttttt acttccttct tatattccta gttcttgacc 5940 ttagttgggg agctggtggt gagggagcac attttaaaca gtttaagcag gtgaggccat 6000 cttgaaggtt tgccccagca gcctgggtga atggagggag tcttgggaga atagataaga 6060 tgcagtcacc acttttaact cttgccctta aaaaatactt ttacaacacg gcttataatg 6120 gaaagagcat taaaatggac attagaaaac tgccagtgat tctaacctta gagagtttgt 6180 acagactccg taagatttgt ttttttagtg ataaagggaa attgtactgg tcattcctta 6240 ataacacatc cagatttctg ttatcactta ccaaaaattt atgaatttga gaattgctta 6300 cacagtatca ggtgctgggt actgggaggt acaaaacaaa gtatagtcag gtaagggcta 6360 actttattac taatttggct cattataaaa acaacgggaa aacatgaaga gagggcttta 6420 ttaaggagtt aagtcagcat aatggaccac ttaatatata ataaccactt aagagaaaaa 6480 gaaaaattag gaagtccaca taaggtggcg ttttataaag gcaacatgct gttgttaagg 6540 gcacttgggc cattggtgtt ttgtgacagc tgggctcagg catctcaaca agcagcggtg 6600 tgcctgctga ccaacagggc ctgccacggc cagtgaaaca cagctattag agctctctca 6660 atccatttct gctcagaaat gtagagatgg caggggaaac gtagctaagt cccaggttcc 6720 tcggatatgg cgagggcaag cactcccata ttataacaac ctgtgcagtc agtgagtcca 6780 gagcagaggc cttgtctcct cctttgctca ccttcactca ctgccctgga ctgtcaggcc 6840 ccagttctca tccccatgtg tgatgaagcc atgcagtccc agagagggag ccatcagcgc 6900 ttggtagtct catgctttag tgtcagagtt gcaccttacc tttgtatcca agaaatgcat 6960 gcagctcaac tttcccttaa aaggcttcta ggaaaaaact accccagcat tttttttccc 7020 ccagaagaat atattagctt aataataaaa ggtatagtaa caaactttcc atttaaaata 7080 gtggcctaag ccacaaattt acctttcctg cccgtatgtg caaaattttc attgaaatga 7140 aaaaatacac actaagaatc aatccagtgt gatgttggaa aagagagaag gttaccattt 7200 tcaaatatga caggtgtttc tggaggtcac aaggcaaatg gtactgggtt gttggaatcc 7260 ctgagctaaa taatggctgt gaaaatgcca gatgagattg gttatctcag cagtgcctgg 7320 gctgtacccc tagcttaggc agcaaaatag gctgtgggcc agtggtctgg tatctgaaag 7380 gattgccaag acaagccttg cggagctcat gcccaactgt tcttgtggaa ccactgggaa 7440 gtggagttcc ctaaatcagg gggagtcatt tacagtcgcc tggcttttgt gggccctgca 7500 gcctgagaag tgagtcagga tggcaggtac ttggttgcca cgttagacag aagcacaagt 7560 atttgatgaa gcagtggaac ttcttgatgt aactcactcc tgtctcggta actttttacc 7620 tacttccaca tttttttaag ggtcgacccc cacttcctac agtttctcta tatccttgcc 7680 actgacacat gcaggcttac gccaagacat agaggaggtc ttgctcacgc cacagttaac 7740 acatctctat ccatggctgg gcaatatgaa agacaattgc taaggaagct ttctcctgtc 7800 agcatactga tcacttttaa agtataactt aacattactt ccccttgtaa aaatcctcca 7860 atagattccc atctaaatga aaataaaatc caaattcctt cctagagcca aatatcattt 7920 ctcttcactc tcctttctta ctttccttca tcccactgga tcttaaggtg caacaaacat 7980 gtttctcata taggaagtgt ggtaggcaga attctgaaga tgttcctcca agagacccat 8040 cccctgctta ttcagtcaaa tctaggtact gctgggaagg gactttgcag aggtaatgcg 8100 gttacagacc tgcagatagg gaggttatct tgaattattt gtgtagggcc aatctaattt 8160 cacaagtcct taaaagcaga gaatgttctc tggctggtta gagaagagga gggctaaaga 8220 ggcagaagaa agatgtggca gagaggatgt ccaagattcc gagcatgaga aggattttct 8280 ctgaagttgc agctctgtga atcaggagcc catgcacgaa ggctggagag aagtctctag 8340 gagctgacag gagcctccag acaatagcca acaaaaacca gaggtgtcag tcctagaact 8400 gcatagaagg gaattctgcc agcaacctaa ataagccagg aagcctcacc cagaggttcc 8460 agatgagaat ccaggccggc tgacaccttg atttcagtct tatgggaccc agagcagaga 8520 aactggtaga gactcctata cttctgatgt acagaactgt ggggtcataa ctgtgtgtgg 8580 ttctaagctg ctaagtttat ggtagtttgt tacagcagca atgtggggta gggaacatta 8640 cactgttctt tgagtgtgga aagctcttcc ttacagctgc tgcttcaagt tagtaaaata 8700 taatttctcc agcaagacct cctttgacca ctggggagat agcctccact aacttccaac 8760 acgtgcatgc catcactatc atattatcct acatttttta ttggtaactg tactaactg 8820 aaaatactta tgcttactgt ctttgtctct aatcctattt cacacccatt agaaagttct 8880 ttacagctag ggactttatg tgcacttcac aaccatgcaa gattcatgag acttctgaaa 8940 aacccaacat catgagaggc acccagagaa gaagcagagt gattcccatc aaagaaaacc 9000 attgattcag gagactgagt agagctttag aaagtctcga tcccagaaga catggtagcc 9060 accaaattaa aataggcagc tattgtatta gtatattgtt acataacaat atcaccacaa 9120 acttagtgac tttaaacaac acacattaat gaccttgtag tttctttcag gcttagctgg 9180 gtcctctgct tcagggaccc acagggctgc aatgaaggtg ttggtcagga ctgtggtctc 9240 atctgaggct tgttggggaa ggatccactt ctcagctcac atggtggttg ggcaacattc 9300 agtttcttac agatggctgg acagagggcc tcagttcttg ccatctgttg gctggaggtt 9360 gccctcagtt ccttgccatg taggcattcc agtgtggctg cttgcttcct caaagccggc 9420 aggggagaga gcctttccag tagcacagat gttactatct tctgtaatgt aatcacacag 9480 gcaacacttt gtcatctttg ctgtattctg tagggtgaga gcaagacaca ggtccttccc 9540 actcttaggg aagggtatta aaaatgacaa ctaccaggag gtagggatca tggagcctgc 9600 ttcagaatct atcacagctg tgaaataaag gcccaggaaa caagaattct aatggttaaa 9660 ataaaaatct tagtggaaga actgaatttt taaaatggaa agggctgaaa caagatagtt 9720 aaaaggaaga ataagctgtg gaattatttt acaatcttca gcagacagag ctagagtgag 9780 gagttaagta gtatgacaga ttccaggtaa ctaatatcca tataatgggg aatctataga 9840 aagtaaaaag gagagaggta gatgataatt gcattattga gagcagataa ttcttctgag 9900 tgaaatacat agttcatatc aaaagcatct actgagtgtg tggtgttata tatatatgta 9960 ggtttttcat ccagggttct ttggctcata actcccacag cccttacaca gtcttgttat 10020 aatgttggat gtgttaggcc tcaggtaggc ctctggtgtt ctgccctcct tccactctaa 10080 tattctccca cctttctgat tgtgggtctt aagactcaaa attccaagag gacagggttc 10140 agagagcttc ccaatagctg aacatgtgga ggttccggga gagtggtgtg cccaggtagg 10200 gcatggaagc ttcaagcctc ttcccccata ccttgcccta gcgtttcttc gtctgtattt 10260 tttccagtat agagcaataa actggtgaac taagtgtt 10298 <210> 21 <211> 3492 <212> DNA <213> FOXE1 <400> 21 gagccggtcc ggtgtgtgca ggggagcgcc tcgccagcgg tccgcagggc tggagaccca 60 cgccgtggag aggaccagcc tcaggtcgcc ccgcctgggc ccgcgccccg acctcgctgc 120 ccccgcctcg cctctctgcc cgtggcgctt acggccacct tggcctcggg ggcagggcat 180 gggcggcccc cgccagatcg cccagcgcca gtactaactg ccctcgctct ggccttcgag 240 cccgaagcct cttctgcgcg cacaacctag gcagtaatcc taaactagcg ggcaccacag 300 accagctgca gccaccccaa cccagggatc acttccggac ccctcgaccg cccggcacca 360 gcgcgcaagg gacccttcag ccggagacca gagtccagtc ccggtcacga ggccaccgcc 420 gctgcccgcc tcgagaagca ccacgcgggc tgagccgtcg gctagcgggt cactcccgag 480 cctctgtctg caccgcgcca gccccagacc acggacgctg agcctccagc gcgtgccagc 540 ctgggccgct gggctctcgg ggccagcccg cgacgatccc ctgagctctc cgcagaaggg 600 ccgagcgtcc gttccgggga cgccaggccc gcccccgccc cccgacagcc gcggggatcc 660 agagcccggg ggtgcgggac gcccgcgcca tgactgccga gagcgggccg ccgccgccgc 720 agccggaggt gctggctacc gtgaaggaag agcgcggcga gacggcagca ggggccgggg 780 tcccagggga ggccacgggc cgcggggcgg gcgggcggcg ccgcaagcgc cccctgcagc 840 gcgggaagcc gccctacagc tacatcgcgc tcatcgccat ggccatcgcg cacgcgcccg 900 agcgccgcct cacgctgggc ggcatctaca agttcatcac cgagcgcttc cccttctacc 960 gcgacaaccc caaaaagtgg cagaacagca tccgccacaa cctcacactc aacgactgct 1020 tcctcaagat cccgcgcgag gccggccgcc cgggtaaggg caactactgg gcgcttgacc 1080 ccaacgcgga ggacatgttc gagagcggca gcttcctgcg ccgccgcaag cgcttcaagc 1140 gctcggacct ctccacctac ccggcttaca tgcacgacgc ggcggctgcc gcagccgccg 1200 ccgccgccgc cgccgccgcc gccgccatct tcccaggcgc ggtgcccgcc gcgcgccccc 1260 cctacccggg cgccgtctat gcaggctacg cgccgccgtc gctggccgcg ccgcctccag 1320 tctactaccc cgcggcgtcg cccggccctt gccgcgtctt cggcctggtt cctgagcggc 1380 cgctcagccc agagctgggg cccgcaccgt cggggcccgg cggctcttgc gcctttgcct 1440 ccgccggcgc ccccgctacc accaccggct accagcccgc aggctgcacc ggggcccggc 1500 cggccaaccc ctccgcctat gcggctgcct acgcgggccc cgacggcgcg tacccgcagg 1560 gcgccggcag tgcgatcttt gccgctgctg gccgcctggc gggacccgct tcgcccccag 1620 cgggcggcag cagtggcggc gtggagacca cggtggactt ctacgggcgc acgtcgcccg 1680 gccagttcgg agcgctggga gcctgctaca accctggcgg gcagctcgga ggggccagtg 1740 caggcgccta ccatgctcgc catgctgccg cttatcccgg tgggatagat cggttcgtgt 1800 ccgccatgtg agccagcgta gggacgaaaa ctcatagaca catcggctgt tcacacgttc 1860 cccgcaatct gagaacgaac aggaatggag agaggactca actgggaccc acgtggaaaa 1920 gaccgagcag gccacagagg ctcggtctcc ccgcgcacag cgtaggcacc cggtgtactc 1980 tgtaaacggg aggaggtggg gcgaggcagc cagagccctt ggactggcac agggaccctc 2040 gatggagcga agccctcaaa cgggatgctt tctggtattc tatcggggag ggtccttggc 2100 ggtaaccaga gggcagcgta gtgtcaacac cagagaccag gatccaaatt gtggggaatc 2160 agtttcagcc ttccatgtgc tgccggaact cgggcctttt tacgcggttc gtcctctagt 2220 gcctttaact gcgttactac aataaaaggc tgcggcagcg cctttcttct taaagtgagg 2280 aggacaaatt tgcaaaagaa ataggctttt cttctttttt aaattggaga aatctctgct 2340 ctggttgacc tgggctggtt ttccctgtct ctgagaactt gagacctagc tccgagttga 2400 actgtgcgtc agcactccag tcccatcacc tgaaccttca gtctccccca tctgttacac 2460 tagagggctg caggactcta tccaccgccc ccgggttatc attcagggcc ccatcatctt 2520 ggatgctgcc ctgcgtattt ggcagcaatg gtgggccacc cagggcctct gagtagccac 2580 ccaaagccta gccgctgttc tagggaacgg aaaagagttc atggccaagc gtctaaccta 2640 aagtcccagg attggctcca ggcagcaatt atatcataac ttattgaact tttgagcagg 2700 acgtgctggt aatttcatgg ctgttactgc ccagtcataa atctgctttt ccattataag 2760 gcagagagaa gtacattcgt tcatttgtcc actgtttctt gtcatcacgc agccctggac 2820 ccaaagggtg aactaaagtt taaggagatg agaggattca aggagcccgt tggtgacgcc 2880 tttcagtagc tggggagggc tcttccatcc ccagcacccc ctgctacacc tcagcagcct 2940 cccccatgca aaaaggaaag agaaaaatta agttagggca gtcagtaaag tgagctttag 3000 aaagaaactg gaattttaac ttcattttgt atcttgctta agtagcaggc tcactaaaat 3060 tagagaaagt ccaataactc tccccctttc ccttgagaaa tctttaagtt tcgattctgg 3120 agcaaaaact ttcagcatta aatatttcag aggctccatt cacagctttc agataaactg 3180 gagtgttcag atggactgtt ttaataaaaa tctttgagca agtgagttat ggcaagagaa 3240 actcagcctc tttctgtata aacttaacag ggaagggctg gggtgtgaaa aagaagattg 3300 tatgaaaacc attggtaatt tttatttttt atttttggga ctgcactatc ctgttcacga 3360 agacatgtga acttggttca gtccaaatgg ggatttgtat aaaccagtgc tctccattag 3420 aaatatggtg caagccacat atgtaatttt aaatattcta gtagccacat taataaagta 3480 aaaagaaaca gg 3492 <210> 22 <211> 1684 <212> DNA <213> FSCN2 <400> 22 agaggcgggt cagagcaggc agggggttcg tgacgccggc tgggtctggg ggctgtgggc 60 cagccgagcc gacccgggct tctgggggac cgcgggggcc gtgagcactc agagggcgca 120 tcccaggccc ctccggggac ccggccagcc tgaagatgcc gacgaacggc ctgcaccagg 180 tgctgaagat ccagtttggc ctcgtcaacg acactgaccg ctacctgaca gctgagagct 240 tcggcttcaa ggtcaatgcc tcggcaccca gcctcaagag gaagcagacc tgggtgctgg 300 aacccgaccc aggacaaggc acggctgtgc tgctccgcag cagccacctg ggccgctacc 360 tgtcggcaga agaggacggg cgcgtggcct gtgaggcaga gcagccgggc cgtgactgcc 420 gcttcctggt cctgccgcag ccagatgggc gctgggtgct gcggtccgag ccgcacggcc 480 gcttcttcgg aggcaccgag gaccagctgt cctgcttcgc cacagccgtt tccccggccg 540 agctgtggac cgtgcacctg gccatccacc cgcaggccca cctgctgagc gtgagccggc 600 ggcgctacgt gcacctgtgc ccgcgggagg acgagatggc cgcagacgga gacaagccct 660 ggggcgtgga cgccctcctc accctcatct tccggagccg acggtactgc ctcaagtcct 720 gtgacagccg ctacctgcgc agcgacggcc gtctggtctg ggagcctgag ccccgtgcct 780 gctacacgct ggagttcaag gcgggcaagc tggccttcaa ggactgcgac ggccactacc 840 tggcacccgt ggggcccgca ggcaccctca aggccggccg aaacacgcga cctggcaagg 900 atgagctctt tgatctggag gagagtcacc cacaggtggt gctggtggct gccaaccacc 960 gctacgtctc tgtgcggcaa ggggtcaacg tctcagccaa tcaggatgat gaactagacc 1020 acgagacctt cctgatgcaa attgaccagg agacaaagaa gtgcaccttc tattccagca 1080 ctgggggcta ctggaccctg gtcacccatg ggggcattca cgccacagcc acacaagttt 1140 ctgccaacac catgtttgag atggagtggc gtggccggcg ggtagcactc aaagccagca 1200 acgggcgcta cgtgtgcatg aagaagaatg ggcagctggc ggctatcagc gattttgtcg 1260 gcaaggacga agagttcacc ctcaagctca tcaaccggcc catcctggtg ctgcgcggcc 1320 tggacggctt cgtctgccac caccgcggct ccaaccagct ggacaccaac cgctccgtct 1380 acgacgtctt ccacctgagc ttcagcgacg gcgcctaccg gatccgaggc cgcgacggag 1440 ggttctggta cacgggcagc cacggcagcg tgtgcagcga cggcgaacgc gccgaggact 1500 tcgtcttcga gttccgtgag cgcggccgcc tggccatccg cgcccggagc ggcaagtacc 1560 tgcgcggcgg cgcctcgggc ctgctgcggg ccgatgccga cgccccggcc gggaccgcgc 1620 tttgggagta ctgaggccgc gcccagacca gcctgtcgcg cattaaaacc gtgtctctcc 1680 cgca 1684 <210> 23 <211> 952 <212> DNA <213> FTMT <400> 23 gatcagatct gacgcctcca gcgcccgacc ccacgccaag agggccgggc ctcagtttcc 60 ccacttccaa ggaggcggcg ctatgctgtc ctgcttcagg ctcctctcca ggcacatcag 120 cccttcgctg gcgtctctgc gcccggtgcg ctgctgcttc gcgctcccgc tgcgttgggc 180 cccggggcgc cccttggacc ccaggcagat cgccccccgc cgccccctgg ccgcagccgc 240 ctcctcccgg gaccctaccg ggcccgccgc cggcccctct cgggtgcgcc agaacttcca 300 ccccgactcc gaggctgcca tcaaccgcca gatcaacctc gagctctatg cgtcctacgt 360 gtacttgtcc atggcctatt acttctcccg ggatgacgtg gccttgaaca acttctccag 420 gtatttcctt caccagtccc gggaggagac cgagcacgcg gagaagctga tgaggctgca 480 gaaccagcga ggaggccgga tccgcctgca ggacatcaag aagccggaac aggacgactg 540 ggaaagcggg ctgcatgcca tggagtgtgc tctactcttg gaaaagaacg tgaaccagtc 600 gttgctggaa ttgcacgctc tagcctcaga taaaggtgac ccccatttgt gcgatttcct 660 ggaaacctac tacctgaatg agcaggtgaa gtctatcaaa gaactaggtg accacgtgca 720 caacttagtg aagatggggg ccccggatgc tggcctggcg gagtaccttt ttgacacaca 780 tacccttgga aatgaaaaca agcagaacta agccacgagc tgccttcctc ccaggctagt 840 ggatccaaag accaaagtca gctgtctcct gctttcttgc ccttaaaatc acctccatct 900 ttatattctt ctgttatact attcctccaa taaagtgatt tgtagaaaaa aa 952 <210> 24 <211> 3875 <212> DNA <213> PI4KB <400> 24 agccggggcc tggtgcagcc tccgcggccg ctgtcaggga agcgcaggcg gccaatggaa 60 cccgggagcg gtcgctgctg ctgaggcggc agtgtcggca gtccaaccgc gactgcccgc 120 accccctccg cgggggtccc ccagaggatc aactaaacct tgaactaaga agaaaaatgt 180 gttgtgagca gggggagcct cagctgcctc aggccgttca ggacagaagg gtgtttctga 240 aggccggagc aagttttgaa gaagtcccta tcagattaca cttggttgac tactccggag 300 cagccactaa gagggatgaa caggcctgcg tggaaattga atgagattct tggaagctcg 360 aagtctggct gtggccatgg gagatacagt agtggagcct gcccccttga agccaacttc 420 tgagcccact tctggcccac cagggaataa tggggggtcc ctgctaagtg tcatcacgga 480 gggggtcggg gaactatcag tgattgaccc tgaggtggcc cagaaggcct gccaggaggt 540 gttggagaaa gtcaagcttt tgcatggagg cgtggcagtc tctagcagag gcaccccact 600 ggagttggtc aatggggatg gtgtggacag tgagatccgt tgcctagatg atccacctgc 660 ccagatcagg gaggaggaag atgagatggg ggccgctgtg gcctcaggca cagccaaagg 720 agcaagaaga cggcggcaga acaactcagc taaacagtct tggctgctga ggctgtttga 780 gtcaaaactg tttgacatct ccatggccat ttcatacctg tataactcca aggagcctgg 840 agtacaagcc tacattggca accggctctt ctgctttcgc aacgaggacg tggacttcta 900 tctgccccag ttgcttaaca tgtacatcca catggatgag gacgtgggtg atgccattaa 960 gccctacata gtccaccgtt gccgccagag cattaacttt tccctccagt gtgccctgtt 1020 gcttggggcc tattcttcag acatgcacat ttccactcaa cgacactccc gtgggaccaa 1080 gctacggaag ctgatcctct cagatgagct aaagccagct cacaggaaga gggagctgcc 1140 ctccttgagc ccggcccctg acacagggct gtctccctcc aaaaggactc accagcgctc 1200 taagtcagat gccactgcca gcataagtct cagcagcaac ctgaaacgaa cagccagcaa 1260 ccctaaagtg gagaatgagg atgaggagct ctcctccagc accgagagta ttgataattc 1320 attcagttcc cctgttcgac tggctcctga gagagaattc atcaagtccc tgatggcgat 1380 cggcaagcgg ctggccacgc tccccaccaa agagcagaaa acacagaggc tgatctcaga 1440 gctctccctg ctcaaccata agctccctgc ccgagtctgg ctgcccactg ctggctttga 1500 ccaccacgtg gtccgtgtac cccacacaca ggctgttgtc ctcaactcca aggacaaggc 1560 tccctacctg atttatgtgg aagtccttga atgtgaaaac tttgacacca ccagtgtccc 1620 tgcccggatc cccgagaacc gaattcggag tacgaggtcc gtagaaaact tgcccgaatg 1680 tggtattacc catgagcagc gagctggcag cttcagcact gtgcccaact atgacaacga 1740 tgatgaggcc tggtcggtgg atgacatagg cgagctgcaa gtggagctcc ccgaagtgca 1800 taccaacagc tgtgacaaca tctcccagtt ctctgtggac agcatcacca gccaggagag 1860 caaggagcct gtgttcattg cagcagggga catccgccgg cgcctttcgg aacagctggc 1920 tcataccccg acagccttca aacgagaccc agaagatcct tctgcagttg ctctcaaaga 1980 gccctggcag gagaaagtac ggcggatcag agagggctcc ccctacggcc atctccccaa 2040 ttggcggctc ctgtcagtca ttgtcaagtg tggggatgac cttcggcaag agcttctggc 2100 ctttcaggtg ttgaagcaac tgcagtccat ttgggaacag gagcgagtgc ccctttggat 2160 caagccatac aagattcttg tgatttcggc tgatagtggc atgattgaac cagtggtcaa 2220 tgctgtgtcc atccatcagg tgaagaaaca gtcacagctc tccttgctcg attacttcct 2280 acaggagcac ggcagttaca ccactgaggc attcctcagt gcacagcgca attttgtgca 2340 aagttgtgct gggtactgct tggtctgcta cctgctgcaa gtcaaggaca gacacaatgg 2400 gaatatcctt ttggacgcag aaggccacat catccacatc gactttggct tcatcctctc 2460 cagctcaccc cgaaatctgg gctttgagac gtcagccttt aagctgacca cagagtttgt 2520 ggatgtgatg ggcggcctgg atggcgacat gttcaactac tataagatgc tgatgctgca 2580 agggctgatt gccgctcgga aacacatgga caaggtggtg cagatcgtgg agatcatgca 2640 gcaaggttct cagcttcctt gcttccatgg ctccagcacc attcgaaacc tcaaagagag 2700 gttccacatg agcatgactg aggagcagct gcagctgctg gtggagcaga tggtggatgg 2760 cagtatgcgg tctatcacca ccaaactcta tgacggcttc cagtacctca ccaacggcat 2820 catgtgacac gctcctcagc ccaggagtgg tggggggtcc agggcaccct ccctagaggg 2880 cccttgtctg agaaacccca aaccaggaaa ccccacctac ccaaccatcc acccaaggga 2940 aatggaaggc aagaaacacg aaggatcatg tggtaactgc gagagcttgc tgaggggtgg 3000 gagagccagc tgtggggtcc agacttgttg gggcttccct gcccctcctg gtctgtgtca 3060 gtattaccac cagactgact ccaggactca ctgccctcca gaaaacagag gtgacaaatg 3120 tgagggacac tggggccttt cttctccttg taggggtctc tcagaggttc tttccacagg 3180 ccatcctctt attccgttct ggggcccagg aagtggggaa gagtaggttc tcggtactta 3240 ggacttgatc ctgtggttgg ccactggcca tgctgctgcc cagctctacc cctcccaggg 3300 acctacccct cccagggacc gacccctggc ccaagctccc cttgctggcg ggcgctgcgt 3360 gggccctgca cttgctgagg ttccccatca tgggcaagga agggaattcc cacagccctc 3420 cagtgtactg agggtactgg cctagccatg tggaattccc taccctgact ccttccccaa 3480 acccagggaa aagagctctc aattttttat ttttaatttt tgtttgaaat aaagtcctta 3540 gttagccact tgtgtcattt ccaggttttc tgggggagtg cagggggaga tgggtgatga 3600 ggtatgaacg gatgcctcag tgtccaagat acaaaaggca ctacatagaa gtttgctttt 3660 tccctgcctg tcttggtcac taccacctct tccctgagaa gggcgggcct tccatgttct 3720 ctcacccgct tcaactccac attgtccaag tcacagaaaa agagaggcct gaatggagat 3780 tcgaccacaa acagttttaa tggtctggtt ttctccctag ttccccaact gtttgttagt 3840 attattatta ctacaagaat aaaggattcc tgaga 3875 <210> 25 <211> 3791 <212> DNA <213> GLYCTK <400> 25 agtacttccg ttctccagcg ctgggcaccg cggccggagc tgtgggctgg cagccatggg 60 tgccaggcag tgctgagagc agtggggcat ggctgcagcc ctgcaggtcc tgccccgctt 120 ggcccgagcc cccttgcatc cactcctctg gcggggctca gtggcccgtc tggccagcag 180 catggccttg gcagagcagg ccaggcagct gtttgagagt gctgtaggtg cagtgctgcc 240 gggccccatg ctgcaccggg cactatcctt ggaccctggt ggcagacagc tgaaggtgcg 300 ggaccggaac tttcagctga ggcaaaacct ctacctggtg ggctttggca aggctgtgct 360 gggtatggca gctgcagctg aggaactact gggccagcat cttgtgcagg gcgtgatcag 420 cgttcccaag gggatccgtg ctgccatgga gcgtgccggc aagcaggaga tgctgctgaa 480 gccacatagc cgtgtccagg tattcgaggg tgcggaggac aacctcccgg accgcgatgc 540 gctgcgggct gcactggcca tccagcaact ggctgaggga ctcacagctg atgacctgct 600 gctcgtgctg atctcaggtg ggggttcagc tctgctgcct gcccccatcc cacctgtcac 660 actggaggag aagcagacac tcactagact gctggcagcc cgtggagcca ccatccagga 720 gttgaacacc attcggaagg ccctgtccca gctcaagggt ggggggctgg ctcaggccgc 780 ctaccctgcc caggtggtga gcctcatcct gtcagatgtg gtgggggacc ctgtggaggt 840 gattgccagt ggccccaccg tggccagttc ccacaatgtg caagattgcc tgcatatcct 900 caatcgctac ggcctccgtg cagccctgcc acgttctgtg aagactgtgc tgtctcgggc 960 cgactctgac ccccatgggc cacacacctg tggccatgtc ctgaatgtga tcattggctc 1020 taatgtgctg gcgctagctg aggcccagcg gcaggccgag gcactgggct accaggctgt 1080 ggtgctgagt gcagccatgc aaggtgatgt aaaaagtatg gcccagttct acgggctgct 1140 ggcccatgtg gctagaaccc gcctcacccc atccatggct ggggcttctg tggaggaaga 1200 tgcacagctc catgagctgg cagctgagct tcagatccca gacctgcagc tggaggaggc 1260 tctggagacc atggcatggg gaaggggccc agtctgcctg ctggctggtg gcgagcccac 1320 agtacagctg cagggctcgg gcaggggtgg ccggaaccag gaactggccc tgcgtgttgg 1380 agcagagttg agaaggtggc cgctggggcc gatagatgtg ctgtttttga gcggtggcac 1440 cgatgggcag gatgggccca cagaggctgc tggggcctgg gtcacacctg agcttgccag 1500 ccaggctgca gctgagggcc tggacatagc caccttccta gcccacaatg actcacatac 1560 cttcttctgc tgcctccagg gtggggcaca cctgctgcac acagggatga caggtaccaa 1620 tgtcatggac acccacctct tgttcctgcg gcctcggtga tggcataggt cacatttgg 1680 gagttcagag gaggcctaca agggcaaggt cagatggcag agcaaggttg gtcctcaggg 1740 cctctctaag ccttagggcc cctcctctcc ttggccttgg ctgtttggtt aactgtcacc 1800 ttccactcag ggcctctgct ctatatctat tcccttccag ccagactggc agatgggggc 1860 ttccccctac ccctgaggat gaggacaagc ccctcggcca gttcagcgtt cccgtgcttc 1920 tcccttgggc agcctctctc ttgagcccct caccctgttt ctttctgtga agcgagaatg 1980 tctgaaaata aataggacca tgccatgggt tctcagtgcg ccttccctca gagtgaggcc 2040 tcacggggga gccgctggga ggggagcgtg gtacggctgc agccacagta ccagggcctg 2100 gcaggactct taacacccct ctactgggct gggtacgtgc aggatgtgcc tcgcataacg 2160 ggagcctgtg cccatccctc tggagtgtgt gagggttgag cttggctcct gacagctttg 2220 atgtgcgtga gcagagaccc cagggaggac aggcctaaag actgcagtct ggggtgacca 2280 gccacccacc cacccaacca tgactccacc atggcactgt caccatggct tctccagcct 2340 cagcttgtag gcctcgttgg atggatgtcc tttctgtctt tggacagccc ttagccacat 2400 actgcacttc tggttgagct gaagtttgtc ccacccccca gtgctgtttc cttgtgacag 2460 cccttgtcct aggctgaaca tccctagttc cttcagccac tcctctgggg accaagtcca 2520 gaccctgaag tcagcccttc agtgggggtc ccagcactgg gatggtgggt ccagccagtg 2580 atgaggtcca gtgacccaca cctcttcctg tgaccactgg cgggagaaga ggcaagtggg 2640 aatagaggaa cggctgtgtt ggcctggcca gcagcctggg ttgagagagg gaggtgccac 2700 tgtcctgcct ccttttgagc ccccttgctc agtgtcagaa ccctccgctg gctgtccccg 2760 ccgtgcgcca cggctccaat ccctatatga gtgagcagta gaatcacata ggaataaaaa 2820 gccatagaga acagcgaggc ctggggctgc tcttgcaggc acttcttcca ccccaaccct 2880 cccctcctcc ctgagggtgt ggaggggccc tgggccaggg ctggcaggac tttcccctgg 2940 gaagggtttc ccttccccac ctgggctctg ggcagcctag cttgcagaca gttcatgacc 3000 tgggggcctg gctcacacag ggcaggctgg agattgggag ggaggtaaac gtggtaagcg 3060 ggctctgggg accagggagg tttaggaaaa ggggagcttg caccccactg ggatgcgcag 3120 gcaccgcttc ctttccttct gtgctggcat ggagttcctg ctgactaggg tcacagtctc 3180 tggggttatg gtgatcctcg catgatcctg tgccgtggtg ctcctctggc agcgtctaca 3240 tgtagcctgt tcctgcctca gtccttgctc ttgggagcat gagtattggc actgggttcc 3300 aagttccagg caaaagcagg ataggagagc tggggcaggg gctgcaggag ctgagggcct 3360 ggcagccatg tccccagtgt gtgtgtgggt ggtaggtgtg tgagtataca gacgttggtg 3420 ttggcgtact cagagtggga atgcatctct gagtgtacac atagatactt agtacagggc 3480 acaggactcc ctgcatccct gctgagggct ttgggtatgg ataggatctt gcaggaggtt 3540 ccccctgctc tacattgacc ccttccctat acttctgttt gtaggggctg ggaggccagg 3600 gcccggattg gaccccatag ggccaaatgg tctgtgagcc taacccgtta gatttgctca 3660 ctggataccc cagagataag aaaggatgta tttggccaca gtctaaatgc tgagatgaga 3720 aaaccctgca cagtgaatgt tttgatagga ttcattactt gctccataaa tgtcaatttt 3780 ggatcattga a 3791 <210> 26 <211> 3718 <212> DNA <213> GLYR1 <400> 26 gtcggcggtg gttgggtggt aagatggcgg ctgtgagtct gcggctcggc gacttggtgt 60 gggggaaact cggccgatat cctccttggc caggaaagat tgttaatcca ccaaaggact 120 tgaagaaacc tcgcggaaag aaatgcttct ttgtgaaatt ttttggaaca gaagatcatg 180 cctggatcaa agtggaacag ctgaagccat atcatgctca taaagaggaa atgataaaaa 240 ttaacaaggg taaacgattc cagcaagcgg tagatgctgt cgaagagttc ctcaggagag 300 ccaaagggaa agaccagacg tcatcccaca attcttctga tgacaagaat cgacgtaatt 360 ccagtgagga gagaagtagg ccaaactcag gtgatgagaa gcgcaaactt agcctgtctg 420 aagggaaggt gaagaagaac atgggagaag gaaagaagag ggtgtcttca ggctcttcag 480 agagaggctc caaatcccct ctgaaaagag cccaagagca aagtccccgg aagcggggtc 540 ggcccccaaa ggatgagaag gatctcacca tcccggagtc tagtaccgtg aaggggatga 600 tggccggacc gatggccgcg tttaaatggc agccaaccgc aagcgagcct gttaaagatg 660 cagatcctca tttccatcat ttcctgctaa gccaaacaga gaagccagct gtctgttacc 720 aggcaatcac gaagaagttg aaaatatgtg aagaggaaac tggctccacc tccatccagg 780 cagctgacag cacagccgtg aatggcagca tcacacccac agacaaaaag ataggatttt 840 tgggccttgg tctcatggga agtggaatcg tctccaactt gctaaaaatg ggtcacacag 900 tgactgtctg gaaccgcact gcagagaaat gtgatttgtt catccaggag ggggcccgtc 960 tgggaagaac ccccgctgaa gtcgtctcaa cctgcgacat cactttcgcc tgcgtgtcgg 1020 atcccaaggc ggccaaggac ctggtgctgg gccccagtgg tgtgctgcaa gggatccgcc 1080 ctgggaagtg ctacgtggac atgtcaacag tggacgctga caccgtcact gagctggccc 1140 aggtgattgt gtccaggggg gggcgctttc tggaagcccc cgtctcaggg aatcagcagc 1200 tgtctaatga cgggatgttg gtgatcttag cggctggaga caggggctta tatgaggact 1260 gcagcagctg cttccaggcg atggggaaga cctccttctt cctaggtgaa gtgggcaatg 1320 cagccaagat gatgctgatc gtgaacatgg tccaagggag cttcatggcc actattgccg 1380 aggggctgac cctggcccag gtgacaggcc agtcccagca gacactcttg gacatcctca 1440 atcagggaca gttggccagc atcttcctgg accagaagtg ccaaaatatc ctgcaaggaa 1500 actttaagcc tgatttctac ctgaaataca ttcagaagga tctccgctta gccattgcgc 1560 tgggtgatgc ggtcaaccat ccgactccca tggcagctgc agcaaatgag gtgtacaaaa 1620 gagccaaggc gctggaccag tctgacaacg atatgtccgc cgtgtaccga gcctacatac 1680 actaagctgt cgacaccccg ccctcacccc tccaatcccc cctctgaccc cctcttcctc 1740 acatggggtc gggggcctgg gagttcattc tggaccagcc cacctatctc catttccttt 1800 tatacagact ttgagacttg ccatcagcac agcacacagc agcacccttc ccctgaggcc 1860 ggtggggagg ggacaagtgt cagcaggatt ggcgtgtggg aaagctcttg agctgggcac 1920 tggccccccg gacgaggtgg ctgtgtgttc acacacacac acacacacac acacacacac 1980 acacacaggc tctcgcccca ggatagaagc tgcccagaaa ctgctgcctg gctttttttc 2040 ttccgagctt gtcttatctc aaaccccttc cagtcaagga actagaatca gcaacgagag 2100 ttggaagcct tcccacagct tcccccagag cgaagaggct gtagtcatgt ccccatcccc 2160 cactggattc cctacaagga gaggccttgg gcccagatga gccagtacag actccagaca 2220 gaggggccct tggggccctc caacctcagg tgatgagctg agaaagatgt tcacgtctaa 2280 gcgtccagtg tgcacccagc gctccataga cgcctttgtg aactgaaaag agactggcag 2340 agtcccgaga agatggggcc ctggctttcc agggagtgca gcaagcagcc ggcctgcagg 2400 tgagcatgga ggcccggccc tcaccgcctc gaagccatgc cccagatgcc actgccacag 2460 cgggcgctcg ctcctcccta ggctgtttta gtatttggat ttgcattcca tcccttggga 2520 gggagtcctc agggccacta gtgatgagcc aagaggagtg ggggttgggg gcgctccttt 2580 ctgtttccgt taggccacag actcttcacc tggctctgaa gagccactct tacctcggtc 2640 ccctcccagt ggtcccacct tctccaccct gccctgccaa gtcccctgca tgccccaccgc 2700 tctccatcct ccctcctctc cctcttcctc ccgtggagac agtatttctt tctgtctgtc 2760 cctttggccc agacccagcc tgaccaacga tgagcatttc ttaggctcag ctcttgatac 2820 ggaaacgagt gtcttcactc cagccagcat catggtcttc ggtgcttccc gggcccgggg 2880 tctgtcggga gggaagagaa ctgggcctga cctacctgaa ctgactggcc ctccgaggtg 2940 ggtctgggac atcctagagg ccctacattt gtccttggat aggggaccgg ggggggcttg 3000 gaatgttgca aaaaaaaaag ttacccaagg gatgtcagtt ttttatccct ctgcatgggt 3060 tggattttcc aaaatcataa tttgcagaag gaaggccagc atttacgatg caatatgtaa 3120 ttatatatag ggtggccaca ctagggcggg gtccttcccc cctcacagct ttggcccctt 3180 tcagagatta gaaactgggt tagaggattg cagaagacga gtggggggag ggcagggaag 3240 atgcctgtcg ggtttttagc acagttcatt tcactgggat tttgaagcat ttctgtctga 3300 acacaaagcc tgttctagtc ctggcggaac acactggggg tgggggcggg ggaagatgcg 3360 gtaatgaaac cggttagtca attttgtctt aatattgttg acaattctgt aaagttcctt 3420 tttatgaata tttctgttta agctatttca cctttctttt gaaatccttc ccttttaagg 3480 agaaaatgtg acacttgtga aaaagcttgt aagaaagccc ctcccttttt tctttaaacc 3540 tttaaatgac aaatctaggt aattaaggtt gtgaattttt atttttgctt tgtttttaat 3600 gaacatttgt ctttcagaat aggattgtgt gataatgttt aaatggcaaa aacaaaacat 3660 gattttgtgc aattaacaaa gctactgcaa gaaaaataaa acacttcttg gtaacaca 3718 <210> 27 <211> 13208 <212> DNA <213> INTU <400> 27 agaggcaaca tggcggcctt agcaagctat agctgcgaga tttgaattac tccactcgta 60 gctattgcat tcctgacgat ggcctctgtg gcttcgtgcg attcgcgtcc gagctcagac 120 gagctccctg gagacccctc ttcacaagaa gaagatgagg actatgattt tgaagatcgg 180 gtcagcgact cgggttcata ttcctcagcg agtagcgatt atgatgatct tgagcctgaa 240 tggctggaca gtgtgcagaa aaatggagag ctgttttatt tggaattgag tgaggatgaa 300 gaagaaagcc tccttcctga gacaccaact gtgaaccatg tcaggttcag tgaaaatgag 360 attatcattg aagatgacta caaagaaaga aaaaagtatg aacccaaact caagcagttt 420 accaaaattt taagaaggaa aagactttta cccaagcgct gcaataaaaa aaatagcaat 480 gacaatggac cagtatccat tctaaagcat cagtccaatc agaagacagg agtcattgtc 540 caacagcgat acaaagatgt gaatgtttat gtaaacccca aaaagctaac tgttatcaaa 600 gccaaagagc agctcaagct tctggaagtg ctggttggaa ttattcatca gaccaagtgg 660 agctggagaa gaaccggaaa gcagggtgat ggagagaggc ttgtggttca tggcctgctg 720 ccagggggat ctgctatgaa gagcggtcag gtactcattg gtgatgtcct tgttgctgtg 780 aatgatgtcg atgttactac tgaaaacatc gagagagttc tgtcttgcat tcctggacct 840 atgcaggtga a actgacatt tgaaaatgca tatgatgtga aaagggagac gtcccatcca 900 agacagaaaa agacacagtc caacacaagt gatttagtca agcttctctg gggagaagag 960 gttgaaggta tccagcagag tggcctaaac actcctcata tcattatgta tctcacacta 1020 cagctcgact cagaaacctc aaaggaagag caggaaattc tttatcatta tccaatgtct 1080 gaagcatctc agaaacttaa aagtgtgaga gggatttttc tcacactctg tgacatgctg 1140 gaaaacgtaa ctgggacaca agttactagt tcatccctcc ttttaaatgg aaaacaaatt 1200 catgtggctt attggaaaga atctgacaag ttgttgctaa ttggcctgcc tgctgaagaa 1260 gttcctcttc ctcgtctaag gaacatgata gaaaatgtca tccaaacctt aaaatttatg 1320 tatggttctt tagatagtgc cttttgccag attgagaatg ttcctcgttt ggatcatttt 1380 tttaacttgt tctttcaaag agcacttcag cctgcgaaac tgcattccag cgccagtccc 1440 agtgctcagc agtacgatgc ttccagtgca gtacttttag acaacctccc tggagtccgg 1500 tggctcacac ttccactgga aatcaagatg gaattagaca tggcattaag tgacttggag 1560 gctgcagatt ttgcagaact gtccgaggat tactatgaca tgaggcggct gtatacaatt 1620 ttggggtctt ctctatttta caagggttat ttgatatgca gtcatttgcc caaggatgat 1680 cttattgata ttgccgtat a ctgtcgccac tattgcctgc tgcctttagc agcaaaacaa 1740 agaattggtc agttgatcat atggagagaa gtgtttcctc agcatcacct ccgacctttg 1800 gcagactcaa gcactgaagt ctttccggaa cctgaaggaa gatatttttt gctagttgtt 1860 ggcttgaaac attatatgct atgtgtacta ttagaagctg gaggttgcgc atccaaagct 1920 attgggagtc ctggaccaga ctgtgtatat gtggatcaag tcaaaacaac tcttcaccag 1980 ctggatggag tagattctcg catagatgaa cggctagcat cttctccagt cccctgtttg 2040 tcttgtgctg actggttcct tactggatca cgtgaaaaaa cagatagctt gaccacttcg 2100 cctattctca gtaggctaca aggtacttcc aaagtagcaa cttctccaac atgcagaaga 2160 acgctttttg gtgactattc cttaaagaca cgcaagccta gtccttcctg tagtagtgga 2220 ggatctgaca atggttgtga aggtggagaa gatgatggct ttagccccca tactacaccg 2280 gatgcagtac ggaagcaaag agaatctcag ggctctgatg gtttagaaga aagtgggacc 2340 ttgcttaagg tcactaaaaa gaagtctact cttccaaatc catttcattt gggaaacttg 2400 aaaaaggacc ttccagaaaa agaattagaa atatataaca cagtgaaact gacatctggt 2460 cctgagaaca cacttttcca ctacgttgcc ttagaaacag tgcaaggaat ctttattact 2520 cctacccttg aagaggtggc acag ctaagt ggctctatcc accctcagct aataaagaat 2580 ttccatcagt gttgtctttc cattcgtgca gttttccaac agacattggt ggaagagaaa 2640 aagaaaggac taaatagtgg agaccattca gattctgcaa agtcagtgtc ttctcttaac 2700 cctgttaaag aacatggtgt gttgtttgaa tgttcacctg gaaactggac tgatcagaaa 2760 aaagcaccac cagttatggc ttactgggta gtagggagac tttttcttca tccaaaacct 2820 caagaacttt atgtctgttt tcatgactca gtcacagaaa ttgccattga aatagctttt 2880 aaattgttct ttgggttaac cttgtagctg tgctttcttg atgcgtagaa acacgtgcat 2940 ggaggatcaa acactgtcag aattgctgaa atcaatacac aaagagataa agtttagctt 3000 ctttttacta ttcaatattg aacataatat tgttaaatat tgagatgaaa tgctgttgga 3060 tttgatacat taaatcttaa tgtaatattg taagactttt gagaatatac ttgattaaaa 3120 tgtgaaagaa gggattgtta acttattgct attttggtat ataatgttaa tttattgact 3180 agtttgaaat aatgtgaagt gttttttata tcagattaat ataggaaatg tttattcttg 3240 aaaaatactc aatttgttgt tgtttatttt tctcaaaatt catactgata tctgatgaaa 3300 tgattatgaa attgggagca ggtgaccagg tgctgtaact aagtagtgct atgaccatga 3360 gcaagttttt gtacctctct aagctcagag ttttcatgta aaatgagatg attgcattga 3420 ggtttcaaaa atacctctta agtaaaatgt gcttttattt tattttagtt ttagttttag 3480 ttctggggta catgtgcagg atgtgcaggt tcgttacata ggtaaacatg tgccatggcg 3540 gtttgctcca cctatcaacc catcacctag gtattaagcc tagcatgcat tagctatttt 3600 tcctaatact ctccctaccc ccacaacagg ccctggtgtg cattgttccc ctccctttgt 3660 ccatgtgttc tcatggtcag ctcccactta taagtgagaa cctacagtgt ttggttttct 3720 gttcctgcat tagtttgctg aggataatgg cttccagctt catccatgtc cctgcagagg 3780 acatgatctc ataccttttt gtggctgcat agtattccat ggtgtatgtg taccacattt 3840 tctttatcca gtctattgct gatgggcatt tgggttgatt ccatgtcttt gctattgtaa 3900 atagtgcttc aatgaacata tgtgtgcata tatatttgta attgaatgat ttatattact 3960 ttgagtataa acccagtaat gggattgctg ggtcaaatgg catttctggt tctagatctt 4020 tgaagaatca ccacactgtc ttccacaatg gttgaactaa ttcacattcc caccaacagt 4080 gtaaaagcgt tcctatttcc tcacagcctc gccagcatct gttatttctt gactttttaa 4140 taatagccac tctgactggt gtgagatgat atctcattgt ggttttgatt tgcatttctc 4200 taacaatcag tgatattgag cttttttttc atatg tttgt tggctgcatg aatgtcttct 4260 tttgagaagt gtctgttcat gtcctttgcc cagtttttaa tgcggttcta ttttttcttg 4320 taacttggtt tgagttcctt gtagatcctg gatatcagat cattgttgga tgaatagatt 4380 gccaaaattt tctcccactc tgtaggttgc ctgttcactc tgatgatagt ttcttttgct 4440 gtgcagaagg tctttaattt aactagatcc catttgtcaa gttttgcttt tgttgcagtt 4500 gcttttgtga tttcatcatg aaatctttgc ccatgctcat gtcttaaatg gtattgccta 4560 gattttcttc tagggatttt atagttttgg gctttacatt taagccttta ttctatctta 4620 attttttgta taaggtatga ggaatgggtc cagtttctat tttctgcata tggatagcta 4680 gttctcccag caccatttat taaataagga atcctttccc cattgcttgt ttttctcagg 4740 tttgttgaag atcagatggt tgtagatgtg caatcttatt tctgagttct ctattctatt 4800 ccattggtct atgtgtcagt ttttgtacca gtaccatgat gttttggtta ttgtaccctt 4860 acagtacagt ttgaagtttg gtagtgtgat gcctccagct ttgatctttt ggcttaggat 4920 tgccttggct atacaggctc tttttttggt tccatataaa ttttaaaata gttttttcta 4980 attctatgaa gaatatcaat ggtagtttaa tgggaataac attgactcta taaattactt 5040 tgggcagtat ggctattttc atgatattga ttcttactgt ctgtgagcat ggaatatttt 5100 tccatttgtt tgtgtcctct ctggtttcct tgagccgtgg tttgtagttc tccttgaaga 5160 ggtccttcac ttcccttgtt agctgtattc ctaggtattt tattctcttt gaagcaattg 5220 tgagtaggag ttcattcatg atttggatct ctgcttgcct gttgttggtg tataggaatg 5280 ctggtgactt ctgcacaatg attttgtatc ttgagacttt gctgaagttg cttatcagct 5340 taagaagctt ttgggctgag acaatggggt tttctagata taggataatg tcctctgcaa 5400 acaaagacat tttgacttcc tctcttcttc tttgaatacc ctttatttct ttctcttgcc 5460 tgattgccct ggccaggact tccaatacta tgttgaatag tggtgagaga ggtcatcctt 5520 gtcttgtgct ggttttcaag gggagtgctt ccagcttttg cccattcggt atgatattgg 5580 ctgtgagtct gtcataaatg gctcttatta ttttgaagta tgttccttca atacctagtt 5640 tattgagagt ttttaacatg aaaggatgtt gaattttatt gaaggtgttt tctgcatcta 5700 ttgagttaat catgtggtct ttgtctttag ttctgtttgt gtgatgaatt aagtttattg 5760 atttgcatat gttgaaccag cctcacatcc cgggaatgaa gccaacttga tcgtggtgga 5820 taagcttttt gatgtgctgc tggattcagt ttgccagtgt tttattgaga atttttacat 5880 tgatgttcat cagggatatt ggtctgaagt tttctttttt tgttgt atct ctgccaggtt 5940 ttgatatcag gatgatgctg gccttataga atgagttagg gaggagtctc tccttttcat 6000 ttgtttggaa tagtttcaga agaagtggta tcagcttctt tttgtatttc tggcagaatt 6060 cagctgtaga tccatctggt cctgggcttt ttttggttgg tagcctatta attactgcct 6120 caatttcaga acttgttatt ggtctattca gtgattcaac ttcttcctgg ttcagtcttg 6180 ggagggtgta tgtgtccagg aatttatcca tttcttctag attttcgagt ttatttgcac 6240 cgagctgtta tagtattgtc tgatggttgt ttatatttcc atgggatcag tggtaatatc 6300 ccctttatca ttttttattg tgtctatttg gttcttctct cttttcttct ttattagtct 6360 agctaatagt ctattttgtt aatattttca aaaaaaagca gcccctggat tcatttattt 6420 tttgaagggt ttttcatgtc tctagctcct tcatttccac tctgattttg gttacttttt 6480 gtcttctgct ggcttttggg tttgtttgct cttggttcac tagttctttt agttgtgata 6540 ctagggtgtc gatttgagat ctttctagct ttttgatgtg ggcatttagt gctataaatt 6600 tccctcttaa cactgcttta gctatgcccc agagattctg gtacattgtc tctttgtttt 6660 cattggtttc aaagaacttc ttgatttctc tcttaatttc attatttacc caggagtcat 6720 tcaggagcag gttgttcaat ttccacgtag ttttgtggtt ttgagtgact t tcttactct 6780 tgagttccaa tttgattgcg ctgtgatctg agagactgtt tgttattact tcagttcttt 6840 agcatttgct gaggagtgct ttacttctaa ttgtgtgatc aattttagag taagtaccat 6900 gtggcactga gaagaatata tattctgttg tttgggggtg gaaagatgtc tagatattta 6960 tcaggtccca cttgatccag agctgaggtc aagtcctgaa taactttgtt aattttctgt 7020 ctcgatgatc taatattgac agtggggtgt taaagtctcc cactattatt gtgtggaaat 7080 ctaagtctct ttttgggtct ctaagaactt gttttatgaa tctgagtgct cctatattag 7140 gtgcatatat atttaggata gttagctctt cttgttgaat tgaccccttt accagtatgt 7200 aatgcctttg tctttttttt aatctttatt cgtttaaagt ctttgtcaga aactaggatt 7260 gcagcctctc ctttttctgt tttccttttg cttggtagat tttccttcat ccttttattt 7320 tgagtctatg tgtgtccttg catgtgagat gggtctcttg aatacagcac actgatagag 7380 tttgactcta tccagcttgc cactctgcgt cttttatttg gggcatttag tgcatttaca 7440 tttaaggtta atattgttat gtgtgaattt tatcctgaca tcatgatgct agttgattat 7500 tttgcagact tgtttatgtt tttgcttcat agtgttactg atctgtgtat ttcaatgtgt 7560 tttttgtagc ggctggtaac agtttttcct ttccatattg agtgcttcct tcaggag cac 7620 ttgcaaggca ggcctggtgg tgacgaattc cctcagcatt tgcttgtctg aaaaagattt 7680 tatttctcct tcacttatga agcttagttc agccagatat gaaattctag gttggaaatt 7740 ctttccttta agaatgttga aaattggccc ccaacctctt ccagcttata aggtttctgc 7800 tgagaggtct gctgttagtc tgatgggctt ccctttataa gtgacctggc ctatctctct 7860 gactgccctt aacatttttt ccttcatttc agtcttggag aatctgatga ttatgtgtct 7920 tggggttgat ctcatggagt attgtattgg ggttctctgg atttcctgaa tttgaatgtt 7980 ggcctgtctt gctaggttgg ggaagttttc ctggatgata tccagaagtg tgttttccaa 8040 cttggttcca ttcttctgtc tctttcaggt atatctacca gtcgtaggtt cagtctttta 8100 acataatccc atagttctca gaggtttcat tcattccttt tcattctttt ttctctaatc 8160 ttgtctgcct gccttatttc agcaagatag tcttcaaact ctgatatcct ttcttccact 8220 tagtctattt ggctatggat acttgtgttt ccattataaa gttctcatgt ttttcagctc 8280 catcagatca tttacgttcc tctccaaact ggttattctg tttaacagct cctataatgt 8340 tttattatgg ttcttagctt ctttgcagtg agttagaaca tattccctta gcttggtgaa 8400 gttcgttatt tcccatcttg gatggatgat tgacattcat ccatctcagc ctcagcccag 84 60 ttctgtgccc ttgctagaga catgttgcaa tcttttggag gagaagaggc actctggctt 8520 tctgagtttt ccgtatcctt gcattctttc tcatcttcat gggtttatct acctttgatc 8580 tttgagtctg ctgacttttg gatgaggttt ttgtggtgtc ttttttgttg atgttgttgc 8640 attctgtttt tctttagtag tcaggcccct cttctgcaga gctgctgcag tttgcctggg 8700 gtccactcta gaccctattc gcctgggtct ctcgtcttcc aggagatatc accagtggag 8760 gctgcagacc agcaaagatg gcagcctgct ccttcctctg ggagctctgt cccagagggg 8820 cactggcctg atgctagccg gaatgctcct gtatgaagtg tctggagact cctgttggga 8880 ggtctcagtc agaaggagcg gggtcagaga accacttaaa taagcagtct gtctgcccct 8940 tgacagggtg ggtgtgctac actgggggga atccccctca tctggactgc cttgactctc 9000 cagagccagc aggcagagaa gactaagatc actgatccat gatacttcag ccatccttcc 9060 tcctaggggc tcctcttggg gttatcagcg ttttgtccat aaacccctgg ctggggatgc 9120 tgagattccc acagggaggc cctgtccagt gaagaggagt gaatctgggt tccaccccat 9180 ctcgccggcg ctagcagcaa gggaaagtgg ccaattgaag ccgcagtgat ggcggcctcc 9240 cctcccttct cccccctctc cttccccact tccagaactc agtcgtctta ggcagtttct 9300 agc tggtggg ggaggattcc aagccagtgg gttttagctt atagagttct gtgagagcaa 9360 ggctgcttgg ctccctggct tcagccccct ccccatgaga gtggacagat ctcctgcctc 9420 acgggagttc ccagagccgg agtatgcaaa tactccagtg tctcagtgcc tgctcaaagc 9480 ggctgcccac ccaagcagag atttgtgctt gggacccaaa gctctggtag cattggctca 9540 ggagggaacc tcctgatcta caagttgcaa ggatctgtgg gaaaagcctg gttttcaggg 9600 aggggaagca aaatccttca ccatctccct tggctggacg agggagttca ctttgctgcg 9660 tgcagttcct ggatgggatc ttgctccacc ctgtttgctt gctctccgtg ggtcatgcca 9720 gccacctagc agtcccaata agagaacttc agtatctcaa ctgaagatgc agagttgact 9780 cacagttttc ttccttcttg gtgggagctg cagagcagag ctgcctctct ttgaccatct 9840 gggctctctg ttctactttt tttttttttt tttttgcctc ttgcatgttg gtcacctcct 9900 aaattagtaa tgtccaagta cttattcctt atcagatact tttcgttaat ttaactatcc 9960 tagtacatac ctcactgtgg ggaaaggggg aaagatgaaa attaaactta ctttttattt 10020 atttgattct ctttaagttt caggtaagct caattttgac taggatatat atatgtgtgt 10080 gtgtgtatat atatgtattt tttaaactat ttgtcaactt tatttttttt tgtttgtttt 10140 tgttaa aata cattcagcgg ctgggcttag tggctcacgc ctgtaatctc aacactttgg 10200 gaggctgagg caggtggatc acttgagtcc aggagttcaa gaccagcctg agcaacatag 10260 caaaaactcc atctctacaa aaacaccaaa attagccggg tgtggtagca ctctctttta 10320 acagtcccag atacctggga ggctgaggtg ggaagatcac ctgagctcag tcggttgagg 10380 ctgcagtgag ctatgatcat gccactgcac tctagcctgg gcaacacagt gagaccctgt 10440 ctcaaaaaaa aaaatcacat tcaagtatat ttcacatgca ttttatataa ttcatgaatt 10500 tcaggaaagc tgcatgtaaa tcttttttta aagctaaatc atgttaaaga cactgaaaaa 10560 gttaactaaa attctatggt gacttctttt ataaaatact aatttttggc cgggcacggt 10620 ggtggctcac gcctgtaatc ccagcacttt gggaggccga ggcaggtgga tcatgaggtc 10680 aggaattcga gaccagcctg accaacatgg tgaaacccca tctctactaa aaatacaaaa 10740 attagctggg cgtggtggtg tgcacctgta atcctagcta cctaggaggc tgaggcagga 10800 gaatcgcttg aacccaggaa gcagaggttg cagtgagcca agatcacacc accgcacttc 10860 tgcctgtgga acagaatgag actccgtctc aaaaaaaaaa aaaaaaatac taacttttat 10920 cttagaaata tagatcatta tgcattgggt tttttcaaag ggggaacact ttagtgaaca 1098 0 atagtttact tgacctttag ttggaaaaga aaactaatgg tggagaattt tctttggctg 11040 ggagaatttg gtagattgag agaaaggaag aacatcaata ctgcattttt acttgacatt 11100 taccctgtag atcctcctag aggttcgatg cccccaagac attccaacac tgagctgttt 11160 cttctccagg tcttaagctt tgaatacaag ctataccagc acatctaaaa tcggtctcta 11220 catttttcca tcttaaatat gagctgtcca gcttagtcaa aactaactgc aaaacactgg 11280 gtgtaccatt tgagtcattt ggtcttaaaa gaaacactat tatcactgtg tcacagtttg 11340 agagattttc acttaagcat ttaagttgca aaccactaca tatttgtccc attagtgact 11400 agtgggcctt aattttggca ttcaaattag ggtaaaaaac cttggttctt gaaatgctac 11460 agaaaatagc ttgaggccag gcacagttgc tcacacctgt aactccagca ctttggaagg 11520 ctgaggcagg cagatcactt gaggtcaggc gtttgagacc aggctggtca acatggtgaa 11580 accctgtctc tactaaaaat actaaaaaaa aaaaaaaaaa aaaaaaaatt agccgggcat 11640 ggtggcaggt gcctgaagtc ccagctactt gggaggctga ggcaggagaa tcacttgaac 11700 ccaggaagca gaggctgcag tgagcctagc tcgtgccact gccactccag cctgggcaac 11760 agaacgaggc tctgtttaaa aaacaaaaaa gcttgaaata ccttcccctt aagatca caa 11820 tattgtcata tgctaccatt tgactcacaa ctgctgtctt aggactgctt atttacatat 11880 atatgtatta agacactttg gttaaaacaa tttattaaat gtcttaaatt tctggatatg 11940 tccctgaaaa taccatgaac tacttctaat actgataatt atgaataaac gtagctgttg 12000 atcacctcag gttttcatac aaactgaact aaggtagggt tttatcatag gggacttttt 12060 gtttcattta atgaaatttt gatgtgttga actgctttcc tggtgtcaga gaaacatgag 12120 accatcgctc aataatggaa ataaaaaggc agagcagact actgatctta ataaaaggaa 12180 aattatttgc tgtatcgtag atgtgcactg taatttccat gttaaagagg cactgcattt 12240 ttaagaaata aaatcacaca tcttattttt tcatttctaa atggatattg aactaagctc 12300 tgaaggcaaa cttagctgcc tatttttcca aatatgttca gaatcacatc tgaaacatca 12360 aactgattat cagacaataa agtgcctgtt actttattaa ataaaggggg acaggatgac 12420 agtgcagata tcctagaaat atgctttaga agacatagaa acgttgttaa attggatttt 12480 attagtatgc aaatgttccc ttccaccaac aactattaat gtgaaaaact atatatagct 12540 agcatttttt aaaatatcaa atactgtctc attatcatat gtttagcccc cccaaaatta 12600 cattttagac tcttactttc tctccctctc ccctttcttt agctcttgtt tgtgtcttgc 12660 caaagaagtg tacctagtaa gggaatgttt cttatttgtg ccaagggact attgatgatg 12720 ctgtataatg gcaagatagc attttgtaat acctgctttt ttatatttct aatacaaatg 12780 ggcaaagctg tgaaaccaat ttactaggtt tttctgcttt ggacataatt gtatgtgtta 12840 attctctcta aacagtgcct ggcacatatt acatgctata aaagtgttag ctactactgc 12900 taccatttat tattatcatt attaaatatc cattggttga aaaaccaagt agtcagctaa 12960 atcatacctg ctactgtaca aaatgtaggg gaaaagctga gaaaaatcat ttatcaataa 13020 acagttttca gaacaagaat ttatactttg gatattttta aattgttaaa tgttattgaa 13080 actttatgca ccaaaactgt atgaaataat ttaattttgc agttgtgttt ctatattcta 13140 tgtaattaaa gctactttta tactatattg atagttttaa ataaaactgg tttggaggtt 13200tgtttgca 13208 <210> 28 <211> 2172 <212> DNA <213> POGLUT2 <400> 28 aaatgatgct ccagtggcag gagcaactca agttcatcat tgtcctgaga gagaggagca 60 gcgcggttct cggccgggac agcagaacgc caggggaccc tcacctgggc gcgccggggc 120 acgggctttg attgtcctgg ggtcgcggag acccgcgcgc ctgccctgca cgccgggcgg 180 caacctttgc agtcgcgttg gctgctgcga tcggccggcg ggtccctgcc gaaggctcgg 240 ctgcttctgt ccacctctta cacttcttca tttatcggtg gatcatttcg agagtccgtc 300 ttgtaaatgt ttggcacttt gctactttat tgcttctttc tggcgacagt tccagcactc 360 gccgagaccg gcggagaaag gcagctgagc ccggagaaga gcgaaatatg gggacccggg 420 ctaaaagcag acgtcgtcct tcccgcccgc tatttctata ttcaggcagt ggatacatca 480 gggaataaat tcacatcttc tccaggcgaa aaggtcttcc aggtgaaagt ctcagcacca 540 gaggagcaat tcactagagt tggagtccag gttttagacc gaaaagatgg gtccttcata 600 gtaagataca gaatgtatgc aagctacaaa aatctgaagg tggaaattaa attccaaggg 660 caacatgtgg ccaaatcccc atatatttta aaagggccgg tttaccatga gaactgtgac 720 tgtcctctgc aagatagtgc agcctggcta cgggagatga actgccctga aaccattgct 780 cagatcaga gagatctggc acatttccct gctgtggatc cagaaaagat tgcagtagaa 840 atcccaaaaa gatttggaca gaggcagagc ctatgtcact acaccttaaa ggataacaag 900 gtttatatca agactcatgg tgaacatgta ggttttagaa ttttcatgga tgccatacta 960 ctttctttga ctagaaaggt agttatatag catcaatatt aagcctcctt taaactaaga 1020 catcagagta ccgtcatact tctcttgctc ctctttgtca atccatggga aaatgagaat 1080 gttcttcagg acttcggttt ctcaagatgc ttctcagact ggtgaagatg ccagatgtgg 1140 agctctttgt taatttggga gactggcctt tggaaaaaaa gaaatccaat tcaaacatcc 1200 atccgatctt ttcctggtgt ggctccacag attccaagga tatcgtgatg cctacgtacg 1260 atttgactga ttctgttctg gaaaccatgg gccgggtaag tctggatatg atgtccgtgc 1320 aagctaacac gggtcctccc tgggaaagca aaaattccac tgccgtctgg agagggcgag 1380 acagccgcaa agagagactc gagctggtta aactcagtag aaaacaccca gaactcatag 1440 acgctgcttt caccaacttt ttcttcttta aacacgatga aaacctgtat ggtcccattg 1500 tgaaacatat ttcatttttt gatttcttca agcataagta tcaaataaat atcgatggca 1560 ctgtagcagc ttatcgcctg ccatatttgc tagttggtga cagtgttgtg ctgaagcagg 1620 attccatcta ctatgaacat ttttacaatg agctgcagcc ctggaaacac tacattccag 1680 ttaagagcaa cctgagcgat ctgctagaaa aacttaaatg ggcgaaagat cacgatgaag 1740 aggccaaaaa gatagcaaaa gcaggacaag aatttgcaag aaataatctc atgggcgatg 1800 acatattctg ttattatttc aaacttttcc aggaatatgc caatttacaa gtgagtgagc 1860 cccaaatccg agagggcatg aaaagggtag aaccacagac tgaggacgac ctcttccctt 1920 gtacttgcca taggaaaaag accaaagatg aactctgata tgcaaaataa cttctattag 1980 aataatggtg ctctgaagac tcttcttaac taaaaagaag aattttttta agtattaatt 2040 ccatggacaa tataaaatct gtgtgattgt ttgcagtatg aagacacatt tctacttatg 2100 cagtattctc atgactgtac tttaaagtac atttttagaa ttttataata aaaccacctt 2160 tattttaaag ga 2172 <210> 29 <211> 5604 <212> DNA <213> KDM4B <400> 29 agggctcggt cgccagcaac cgagcggggc ccggcccgag cggggcctgg gggtgcgacg 60 ccgagggcgg gggagagcgc gccgctgctc ccggaccggg ccgcgcacgc cgcctcagga 120 accatcactg ttgctggagg cacctgacaa atcctagcga atttttggag catctccacc 180 caggaacctc gccatccaga agtgtgcttc ccgcacagct gcagccatgg ggtctgagga 240 ccacggcgcc cagaacccca gctgtaaaat catgacgttt cgcccaacca tggaagaatt 300 taaagacttc aacaaatacg tggcctacat agagtcgcag ggagcccacc gggcgggcct 360 ggccaagatc atccccccga aggagtggaa gccgcggcag acgtatgatg acatcgacga 420 cgtggtgatc ccggcgccca tccagcaggt ggtgacgggc cagtcgggcc tcttcacgca 480 gtacaatatc cagaagaagg ccatgacagt gggcgagtac cgccgcctgg ccaacagcga 540 gaagtactgt accccgcggc accaggactt tgatgacctt gaacgcaaat actggaagaa 600 cctcaccttt gtctccccga tctacggggc tgacatcagc ggctctttgt atgatgacga 660 cgtggcccag tggaacatcg ggagcctccg gaccatcctg gacatggtgg agcgcgagtg 720 cggcaccatc atcgagggcg tgaacacgcc ctacctgtac ttcggcatgt ggaagaccac 780 cttcgcctgg cacaccgagg acatggacct gtacagcatc aactacctgc actttgggga 840 gcctaagtcc tggtacgcca tcccaccaga gcacggcaag cgcctggagc ggctggccat 900 cggcttcttc cccgggagct cgcagggctg cgacgccttc ctgcggcata agatgaccct 960 catctcgccc atcatcctga agaagtacgg gatccccttc agccggatca cgcaggaggc 1020 cggggaattc atgatcacat ttccctacgg ctaccacgcc ggcttcaatc acgggttcaa 1080 ctgcgcagaa tctaccaact tcgccaccct gcggtggatt gactacggca aagtggccac 1140 tcagtgcacg tgccggaagg acatggtcaa gatctccatg gacgtgttcg tgcgcatcct 1200 gcagcccgag cgctacgagc tgtggaagca gggcaaggac ctcacggtgc tggaccacac 1260 gcggcccacg gcgctcacca gccccgagct gagctcctgg agtgcatccc gggcctcgct 1320 gaaggccaag ctcctccgca ggtctcaccg gaaacggagc cagcccaaga agccgaagcc 1380 cgaagacccc aagttccctg gggagggtac ggctggggca gcgctcctag aggaggctgg 1440 gggcagcgtg aaggaggagg ctgggccgga ggttgacccc gaggaggagg aggaggagcc 1500 gcagccactg ccacacggcc gggaggccga gggcgcagaa gaggacggga ggggcaagct 1560 gcggccaacc aaggccaaga gcgagcggaa gaagaagagc ttcggcctgc tgcccccaca 1620 gctgccgccc ccgcctgctc acttcccctc agaggaggcg ctgtggctgc catccccact 1680 ggagcccccg gtgctgggcc caggccctgc agccatggag gagagccccc tgccggcacc 1740 ccttaatgtc gtgccccctg aggtgcccag tgaggagcta gaggccaagc ctcggcccat 1800 catccccatg ctgtacgtgg tgccgcggcc gggcaaggca gccttcaacc aggagcacgt 1860 gtcctgccag caggcctttg agcactttgc ccagaagggt ccgacctgga aggaaccagt 1920 ttcccccatg gagctgacgg ggccagagga cggtgcagcc agcagtgggg caggtcgcat 1980 ggagaccaaa gcccgggccg gagaggggca ggcaccgtcc acatttcca aattgaagat 2040 ggagatcaag aagagccggc gccatcccct gggccggccg cccacccggt ccccactgtc 2100 ggtggtgaag caggaggcct caagtgacga ggaggcatcc cctttctccg gggaggaaga 2160 tgtgagtgac ccggacgcct tgaggccgct gctgtctctg cagtggaaga acagggcggc 2220 cagcttccag gccgagagga agttcaacgc agcggctgcg cgcacggagc cctactgcgc 2280 catctgcacg ctcttctacc cctactgcca ggccctacag actgagaagg aggcacccat 2340 agcctccctc ggagagggct gcccggccac attaccctcc aaaagccgtc agaagacccg 2400 accgctcatc cctgagatgt gcttcacctc tggcggtgag aacacggagc cgctgcctgc 2460 caactcctac atcggcgacg acgggaccag ccccctgatc gcctgcggca agtgctgcct 2520 gcaggtccat gccagttgct atggcatccg tcccgagctg gtcaatgaag gctggacgtg 2580 ttcccggtgc gcggcccacg cctggactgc ggagtgctgc ctgtgcaacc tgcgaggagg 2640 tgcgctgcag atgaccaccg ataggaggtg gatccacgtg atctgtgcca tcgcagtccc 2700 cgaggcgcgc ttcctgaacg tgattgagcg ccaccctgtg gacatcagcg ccatccccga 2760 gcagcggtgg aagctgaaat gcgtgtactg ccggaagcgg atgaagaagg tgtcaggtgc 2820 ctgtatccag tgctcctacg agcactgctc cacgtccttc cacgtgacct gcgcccacgc 2880 cgcaggcgtg ctcatggagc cggacgactg gccctatgtg gtctccatca cctgcctcaa 2940 gcacaagtcg gggggtcacg ctgtccaact cctgagggcc gtgtccctag gccaggtggt 3000 catcaccaag aaccgcaacg ggctgtacta ccgctgtcgc gtcatcggtg ccgcctcgca 3060 gacctgctac gaagtgaact tcgacgatgg ctcctacagc gacaacctgt accctgagag 3120 catcacgagt agggactgtg tccagctggg acccccttcc gagggggagc tggtggagct 3180 ccggtggact gacggcaacc tctacaaggc caagttcatc tcctccgtca ccagccacat 3240 ctaccaggtg gagtttgagg acgggtccca gctgacggtg aagcgtgggg acatcttcac 3300 cctggaggag gagctgccca agagggtccg ctctcggctg tcactgagca cgggggcacc 3360 gcaggagccc gccttctcgg gggaggaggc caaggccgcc aagcgcccgc gtgtgggcac 3420 cccgcttgcc acggaggact ccgggcggag ccaggactac gtggccttcg tggagagcct 3480 cctgcaggtg cagggccggc ccggagcccc cttctaggac agctggccgc tcaggcgacc 3540 ctcagcccgg cggggaggcc atggcatgcc ccgggcgttc gcttgctgtg aattcctgtc 3600 ctcgtgtccc cgacccccga gaggccacct ccaagccgcg ggtgccccct agggcgacag 3660 gagccagcgg gacgccgcac gcggccccag actcagggag cagggccagg cgggctcggg 3720 ggccggccag gggagcaccc cactcaacta ctcagaattt taaaccatgt aagctctctt 3780 cttctcgaaa aggtgctact gcaatgccct actgagcaac ctttgagatt gtcacttctg 3840 tacataaacc acctttgtga ggctctttct ataaatacat attgtttaaa aaaaagcaag 3900 aaaaaaagga aaacaaagga aaatatcccc aaagttgttt tctagatttg tggctttaag 3960 aaaaacaaaa caaaacaaac acattgtttt tctcagaacc aggattctct gagaggtcag 4020 agcatctcgc tgtttttttg ttgttgtttt aaaatattat gatttggcta cagaccaggc 4080 agggaaagag acccggtaat tggagggtga gcctcggggg gggggcagga cgccccggtt 4140 tcggcacagc ccggtcactc acggcctcgc tctcgcctca ccccggctcc tgggctttga 4200 tggtctggtg ccagtgcctg tgcccactct gtgcctgctg ggaggaggcc caggctctct 4260 ggtggccgcc cctgtgcacc tggccagggg aagcccgggg gtctggggcc tccctccgtc 4320 tgcgcccacc tttgcagaat aaactctctc ctggggtttg tctatctttg tttctctcac 4380 ctgagagaaa cgcaggtgtt ccagaggctt ccttgcagac aaagcacccc tgcacctcct 4440 atggctcagg atgagggagg cccccaggcc cttctggttg gtagtgagtg tggacagctt 4500 cccagctctt cgggtacaac cctgagcagg tcgggggaca cagggccgag gcaggccttc 4560 ggggcccctt tcgcctgctt ccgggcaggg acgaggcctg gtgtcctcgc tccacccacc 4620 cacgctgctg tcacctgagg ggaatctgct tcttaggagt gggttgagct gatagagaaa 4680 aaacggcctt cagcccaggc tgggaagcgc cttctccagg tgcctctccc tcaccagctc 4740 tgcacccctc tggggagcct tccccacctt agctgtctcc tgccccaggg agggatggag 4800 gagataattt gcttatatta aaaacaaaaa atggctgagg caggagtttg ggaccagcct 4860 gggctatata gcaagacccc atcactacaa attttttaca aattagctag gtgtggtggt 4920 gcgcacctgt ggtcccagct actcgggagg ctgtggtggg aggattgctt gagtccagga 4980 ggttgaggct gcagtcagct cagattgcac cactgcactc cagcctgggc aacagagcga 5040 gaccctgtct ccaaaaaaaa aaaaaagcaa tgtttatatt ataaaagagt gtcctaacag 5100 tccccgggct agagaggact aaggaaaaca gagagagtgt tacgcaggag caagcctttc 5160 atttccttgg tgggggaggg gggcggttgc cctggagagg gccggggtcg gggaggttgg 5220 ggggtgtcag ccaaaacgtg gaggtgtccc tctgcacgca gccctcgccc ggcgtggcgc 5280 tgacactgta ttcttatgtt gtttgaaaat gctatttata ttgtaaagaa gcgggcgggt 5340 gcccctgctg cccttgtccc ttgggggtca cacccatccc ctggtgggct cctgggcggc 5400 ctgcgcagat gggccacaga agggcaggcc ggagctgcac actctcccca cgaaggtatc 5460 tctgtgtctt actctgtgca aagacgcggc aaaacccagt gccctggttt ttccccaccc 5520 gagatgaagg atacgctgta ttttttgcct aatgtccctg cctctaggtt cataatgaat 5580 taaaggttca tgaacgctgc gaaa 5604 <210> 30 <211> 6685 <212> DNA <213> KIAA0355 <400> 30 gtaacttccg gtgtacacag ccggtccaag gcggtgcgct gggggccggg gcgcgtcgca 60 ggaaaggact tagaagcctt acaaatacat ctgtgcattc ttgcttcaga ctttacaact 120 gagggccagc ccagtctgga agcatctctt attaatgtta caaggaaacc gctacctcag 180 caaacaaaag gaatggagga ggagacttac aacaaacgcc atttaaaaaa aaaagaaaaa 240 cttgttttca ggaaacatta gaggaaattt ggagaatttc agcattgcat agaagcagcc 300 ttacaggtaa acggatttga cgggcaggct ctgtcaaaat tctgcagaag tttgatcttc 360 cttcttaagg actttgtgtg aagtaattct ttactgcttt taaattgctg ttgatcagct 420 tctgggtttt tgggttctaa cttttttggg tatattgaag acacagtgta ttacattata 480 ttacattttt aaacgttaag ttatttttct gccattgtaa atacaagtat caaaatattc 540 ttgcaaagaa gtaaacattt ttctcagcaa gcatatcctt ttagtaagag agtggaatgc 600 taaacagttc ttatccagca ttttggacat cttttatttt ttgtcagaga tcctgtctac 660 actgaaaata ttaattatat aaacctgttg tctctcacct ctacattgga tcacatggtc 720 acctgcctca tggaaatgcc ttttttaaaa cttcgatttg cagaactcca ctatttttat 780 acctagctac agttttgaga aagaagaatc agaaccctga cccacttacg gttgctggga 840 caattccccc tcccgcatgt attgctgcag tgcccaggac agtaaaatgg actacaagcg 900 gcgcttcctg cttggcgggt ccaagcagaa ggtgcagcag caccagcaat acccgatgcc 960 tgagctgggc cgagcactga gtgctcccct ggcatccacg gccaccactg cccccctggg 1020 cagtctgacc gctgcaggca gctgccacca tgccatgccc cacactactc ctatcgccga 1080 catccagcag ggcatctcca agtatctgga tgccctgaac gtcttctgcc gtgccagtac 1140 tttcctcaca gatctcttca gcactgtgtt caggaactct cactactcaa aggcagccac 1200 acagctcaaa gatgtgcagg agcatgtcat ggaagcagcc agtcggctga cctcggccat 1260 aaagcctgag atcgccaaga tgctaatgga acttagtgct ggggctgcaa attttacgga 1320 tcagaaggaa ttcagtctcc aggacattga ggtgttgggg cgatgtttcc tgactgtggt 1380 gcaagtccat ttccagtttt tgactcatgc gttacagaag gtccagccgg tggctcactc 1440 ttgctttgct gaggtcatcg tgccagaaaa aaagaacagc ggcagtggcg gcggcttatc 1500 tggcatgggc cacacacctg aagtagagga agctgtgcgg tcctggcggg gggctgctga 1560 ggcgacatct agactaagag aaagaggctg tgatggttgc ctggcaggaa ttgaagttca 1620 acaactcttt tgttctcaaa gtgcagcaat tcctgagcac cagctaaaag aactgaacat 1680 aaaaatcgac agtgctttgc aagcatataa gatagctctg gaaagcttag gacactgtga 1740 atatgcaatg aaagccggct tccacctgaa tccaaaggcg attgaagcaa gtttgcaggg 1800 ctgctgcagc gaggcggaag cccagcagac ggggcggagg cagacacccc cgcagcccat 1860 gcagtgtgag ctccccaccg tccctgtgca gataggatcg cacttcctga agggcgtctc 1920 ctttaatgag tcggccgccg acaatctgaa acttaagacg catacaatgt tacagctgat 1980 gaaggaggca ggctgctata atggaatcac atccagggat gattttcctg tgactgaagt 2040 gctgaaccag gtttgccctt ccacatggcg aggtgcctgc aagacggcgg tgcagctgct 2100 gtttggccag gctggactgg tggtggttga cacagcacag attgagaata aagaagccta 2160 tgccccccag atcagtttag aaggctctag aatcgtggtt caagtcccat ccacatggtg 2220 cctgaaagaa gaccctgcta ccatgtccct gctgcagaga agccttgatc ctgagaagac 2280 cctgggtcta gtggacgtgc tctacacagc tgtgctggac ctaaaccgct ggagggctgg 2340 aagggagcaa gctttaccct gcatacagat ccagctgcaa agggagatct gtgattttgg 2400 caaccaggct gacctgcctt ctggaaatgg aaacaaatct tcaggtggcc tgcagaagac 2460 attctccaaa ctgacatccc ggttcaccaa gaaagcttca tgtaccagct ccagcagcag 2520 cacaaattat tccatccaaa ataccccttc caaaaacatc ttcatagctg gatgttccga 2580 agagaaggcc aaaatgcctg gcaatattga tacaaggtta caaagcattt tgaacattgg 2640 taatttcccc aggactacag acccttcaca gtcagctcag aattccagta atacagtggc 2700 caatggcttt ctcatggaga ggcgtgagaa cttcctgcat ggagatgacg gcaaggatga 2760 gaagggtatg aacttaccaa ctgatcagga aatgcaagag gtgatagatt ttctctcggg 2820 ctttaacatg ggccagtcac atcagggctc tccgttggtg acaaggcata attctgctgc 2880 cacagccatg gtgactgagc agaaggcagg agccatgcaa ccacagcagc cgtcactgcc 2940 tgtgccccct ccaccacggg caccccaggc tggggcacac acacctctga caccccagcc 3000 gggactggca cctcagcagc agtccccaaa gcagcaacaa cctcaagtcc aatactacca 3060 acacctactc cagcccattg gaccgcagca gcccccgccc cagcctcggg cacctgggaa 3120 atgggtacat ggctcatccc agcagccagc gcaggctgtt ggagcaggtc tgtctcctct 3180 tggtcagtgg cctggcatat ctgatctcag ttctgacttg tacagcttgg gtctggtgag 3240 cagctatatg gataatgtga tgtcagaggt tctgggacag aagccgcagg gacctagaaa 3300 taacacctgg cccaaccgtg accaaagtga tggagtcttt ggaatgctgg gagagattct 3360 gccttttgat cctgcagtgg gctcagaccc agagtttgca cgctatgtgg caggagtgag 3420 ccaggcgatg cagcagaagc ggcaggccca gcacggtcgc cggccaggca acccccgggg 3480 caactggccg cctatggatg acgcgcatcg gacctggccc ttccccgagt tcttcacaga 3540 aggggatggc ctgcacggtg gctggtcggg tgctcaggga gactctgcca gctcgagtga 3600 tgagacatcc tcagccaacg gggacagctt gttctccatg ttttcagggc ctgacctcgt 3660 tgctgctgtc aagcagagaa ggaaacacag cagtggagag caagacacca gcacgctgcc 3720 ctcaccacct ctcctcacca cggtggagga tgtgaaccag gataacaaaa ccaaaacgtg 3780 gccacccaaa gcaccctggc agcacccttc cccgcttccc agcacgctgc ccagccccag 3840 cgcaccactc tatgcagtca ccagccctgg cagccagtgg aacgacacca tgcagatgct 3900 gcagtcccca gtgtgggccg caaccaacga ctgcagtgcc gctgccttct cctatgtgca 3960 gaccccaccc cagccccccac ccccaccagc acacaaggca gcacccaagg gcttcaaggc 4020 cttccctggg aagggtgagc gcaggccagc ctatctgccc cagtactgac cccaggccag 4080 ccagcctgcc tgcctgcctg cctgcccgcc cagagctgtg gggatgagtg tccccacccc 4140 agggccactt agctgacacc agcccctcag aggaccagtg cgccccatcc cagggagggt 4200 tccttgggga caagggtggt tggcagctcc aagcctttaa acctggcttc tgaaacgatg 4260 gcatcagagc cctggagagc cagctggaga cacaggcgtc tggccttcag gggcttgcta 4320 gggaacctgc atgcctagta agcgccacag gtgactctga tgcaggcgcc acagccacac 4380 ttgaagaaac acagctcttg ggtttttagt cctgctgtgt gttgggaaga catcaggcct 4440 gaaagctgag ggcataactg accatttttt ggaaaccctc tcctccctcc tccacacctt 4500 gagtgatgac cacaccaatc actgtatttt atagcttttt ttttcatgta ggtttttagt 4560 taaaacatct cctgcctaaa atgcattgaa tattttaaga taacagatat actggctgga 4620 ggtttgttta acactatcta tatttaagct tatacaaaat gggcaaaata tagaatattt 4680 gtgattggaa gcagtcacct ggggtttctg ggggtggaca gttcctcgcc acccagcagc 4740 accctgggac tgcggccttt cccagcttta ttgaagcaga atggtggaac ttgtgccgga 4800 ggtacactgc tgaaggtgcg tggcggtgga ccagccagct gctgtccatg tgcagagcaa 4860 ggctgcacct gctgcccttc gatccttcca cacatggcca ggacactgcc acaatcctcg 4920 gggtgtggtc aaggggcact cagagacacc tgcactagaa attgcattga cattgtgagc 4980 tggctcagaa gacaaaccaa ttaagatgta gatagaaatt aatttaaggt cttttcttaa 5040 aaaaaaaatc cacctcattt tcagttaaca tgtgccatta aatagataac atcctgtgga 5100 tttagggata ttttccagcc agaatggatc cagaagaatt gaatggtgct taaattgaga 5160 aataataata aatatatcta tatagaatag acatatccca ctgtatatta attgaggtta 5220 cagaaagttc tttatataaa acttatttaa atttttcata tttcatcttt gaaaaagtct 5280 gagaaaaatc cataatattt tctggtatga aagtttgaca gtattaatat tttttttata 5340 ttttcttaaa tcattaaacc attttaatat atgttaacta ctaataaatg gtttattctt 5400 tctaactcca tataagcttt tccagcaaag attgtaataa cacatttatg ttctcgtttt 5460 tctacagata taagtaaatt tatatataaa aataccaaaa agaggctggg cgtggtggct 5520 cacgcctgta atcccagcac tttgggaggc cgaggcaggt ggatcaccta aggtcaggag 5580 ttcgagacca gcctggccaa tatggtgaaa ccccatctct actaaaaata caaaaattag 5640 ccgggtgtgg tggcgtgcgc ctgtagtccc agctactcgg gaggctgaag cagaagaatc 5700 gcttgaaccc gggaggcgga ggttacagtg agctgagatt gtgccactgc actccagcct 5760 gggtgacaga gtgagattcc gtctcaacaa gaaaaaaaaa aaagaatata tatatatgta 5820 tgtatgtatg tatgtaaaca cacacactaa tttgagagga cccgtagggt gtctgagccc 5880 agccacctga gtttttagta ctgtgttgtc aggctcttcc caggcctcag gtgttgtctt 5940 ttgtgctgtg tggggatgca ttgctgcctg tatttatgat cttttgccgt ggttctgagc 6000 attcacctca ccatgtttac aaagaactgt tttgtatata gacattttca ggcacgtgct 6060 ttgcaccaac cctgcgtggc tcttgtctgt gttagctgtc acggtgtgca cactaatctc 6120 tgttaaagtt gtctatggct gttctacttg taagatagtt ttctatttcc ttcagtaatg 6180 tgtccacagt accctgtatt tcgagttcca ttatactgaa gtactcatgt tttaatagtg 6240 cctctccaaa ggcctcacct tggacagagg tcaatccttg atgctccagc acaggtgacg 6300 tcactaattg tcactttcca gtttgttttt ctctattaag gaagacattt tctaattgca 6360 tctccatggg ctgtgagact gtgtgaagcc gtttgtgtgg tctccatgta ggtgctgtgt 6420 tcccggcacc gccttgctct gaacactggt aattccaggt gctgcgcttg gcagaggggt 6480 ctcgccaaag cgcatgtgtg tgcatgtgtg aacgtgtgtg tcctttgcat ggttgggcgt 6540 gggtgccttg ctagggcatc agcaggacat tgtgtgtata gttacaatgc ttccaaactg 6600 gaactctaca ttttgtatct tttaaagctc ctataagtaa aataactatt ggctttatta 6660 aaaatataca tttaataata ctttg 6685 <210> 31 <211> 2980 <212> DNA <213> KIRREL2 <400> 31 agagacccag gccgcggaac tggcaggcgt ttcagagcgt cagaggctgc ggatgagcag 60 acttggagga ctccaggcca gagactaggc tgggcgaaga gtcgagcgtg aagggggctc 120 cgggccaggg tgacaggagg cgtgcttgag aggaagaagt tgacgggaag gccagtgcga 180 cggcaaatct cgtgaacctt gggggacgaa tgctcaggat gcgggtcccc gccctcctcg 240 tcctcctctt ctgcttcaga gggagagcag gcccgtcgcc ccatttcctg caacagccag 300 aggacctggt ggtgctgctg ggggaggaag cccggctgcc gtgtgctctg ggcgcctact 360 gggggctagt tcagtggact aagagtgggc tggccctagg gggccaaagg gacctaccag 420 ggtggtcccg gtactggata tcagggaatg cagccaatgg ccagcatgac ctccacatta 480 ggcccgtgga gctagaggat gaagcatcat atgaatgtca ggctacacaa gcaggcctcc 540 gctccagacc agcccaactg cacgtgctgg tccccccaga agccccccag gtgctgggcg 600 gcccctctgt gtctctggtt gctggagttc ctgcgaacct gacatgtcgg agccgtgggg 660 atgcccgccc tacccctgaa ttgctgtggt tccgagatgg ggtcctgttg gatggagcca 720 ccttccatca gaccctgctg aaggaaggga cccctgggtc agtggagagc accttaaccc 780 tgaccccttt cagccatgat gatggagcca cctttgtctg ccgggcccgg agccaggccc 840 tgcccacagg aagagacaca gctatcacac tgagcctgca gtacccccca gaggtgactc 900 tgtctgcttc gccacacact gtgcaggagg gagagaaggt cattttcctg tgccaggcca 960 cagcccagcc tcctgtcaca ggctacaggt gggcaaaagg gggctctccg gtgctcgggg 1020 cccgcgggcc aaggttagag gtcgtggcag acgcctcgtt cctgactgag cccgtgtcct 1080 gcgaggtcag caacgccgtg ggtagcgcca accgcagtac tgcgctggat gtgctgtttg 1140 ggccgattct gcaggcaaag ccggagcccg tgtccgtgga cgtgggggaa gacgcttcct 1200 tcagctgcgc ctggcgcggg aacccgcttc cacgggtaac ctggacccgc cgcggtggcg 1260 cgcaggtgct gggctctgga gccacactgc gtcttccgtc ggtggggccc gaggacgcag 1320 gcgactatgt gtgcagagct gaggctgggc tatcgggcct gcggggcggc gccgcggagg 1380 ctcggctgac tgtgaacgct cccccagtag tgaccgccct gcactctgcg cctgccttcc 1440 tgaggggccc tgctcgcctc cagtgtctgg ttttcgcctc tcccgcccca gatgccgtgg 1500 tctggtcttg ggatgagggc ttcctggagg cggggtcgca gggccggttc ctggtggaga 1560 cattccctgc cccagagagc cgcgggggac tgggtccggg cctgatctct gtgctacaca 1620 tttcggggac ccaggagtct gactttagca ggagctttaa ctgcagtgcc cggaaccggc 1680 tgggcgaggg aggtgcccag gccagcctgg gccgtagaga cttgctgccc actgtgcgga 1740 tagtggccgg agtggccgct gccaccacaa ctctccttat ggtcatcact ggggtggccc 1800 tctgctgctg gcgccacagc aaggcctcag cctctttctc cgagcaaaag aacctgatgc 1860 gaatccctgg cagcagcgac ggctccagtt cacgaggtcc tgaagaagag gagacaggca 1920 gccgcgagga ccggggcccc attgtgcaca ctgaccacag tgatctggtt ctggaggagg 1980 aagggactct ggagaccaag gacccaacca acggtacta caaggtccga ggagtcagtg 2040 tgagcctgag ccttggcgaa gcccctggag gaggtctctt cctgccacca ccctcccccc 2100 ttgggccccc agggacccct accttctatg acttcaaccc acacctgggc atggtccccc 2160 cctgcagact ttacagagcc agggcaggct atctcaccac accccaccct cgagctttca 2220 ccagctacat caaacccaca tcctttgggc ccccagatct ggcccccggg actcccccct 2280 tcccatatgc tgccttcccc acacctagcc acccgcgtct ccagactcac gtgtgacatc 2340 tttccaatgg aagagtcctg ggatctccaa cttgccataa tggattgttc tgatttctga 2400 ggagccagga caagttggcg accttactcc tccaaaactg aacaaaggg gagggaaaga 2460 tcattacatt tgtcaggagc atttgtatac agtcagctca gccaaaggag atgccccaag 2520 tgggagcaac atggccaccc aatatgccca cctattcccc ggtgtaaaag agattcaaga 2580 tggcaggtag gccctttgag gagagatggg gacagggcag tgggtgttgg gagtttgggg 2640 ccgggatgga agttgtttct agccactgaa agaagatatt tcaagatgac catctgcatt 2700 gagaggaaag gtagcatagg atagatgaag atgaagagca taccaggccc caccctggct 2760 ctccctgagg ggaactttgc tcggccaatg gaaatgcagc caagatggcc atatactccc 2820 taggaaccca agatggccac catcttgatt ttactttcct taaagactca gaaagacttg 2880 gacccaagga gtggggatac agtgagaatt accactgttg gggcaaaata ttgggataaa 2940 aatatttatg tttaataata aaaaaaagtc aaagaggcaa 2980 <210> 32 <211> 2258 <212> DNA <213> KLKB1 <400> 32 agtgccacat tagaacagct tgaagaccgt tcatttttaa gtgacaagag actcacctcc 60 aagaagcaat tgtgttttca gaatgatttt attcaagcaa gcaacttatt tcatttcctt 120 gtttgctaca gtttcctgtg gatgtctgac tcaactctat gaaaacgcct tcttcagagg 180 tggggatgta gcttccatgt acaccccaaa tgcccaatac tgccagatga ggtgcacatt 240 ccacccaagg tgtttgctat tcagttttct tccagcaagt tcaatcaatg acatggagaa 300 aaggtttggt tgcttcttga aagatagtgt tacaggaacc ctgccaaaag tacatcgaac 360 aggtgcagtt tctggacatt ccttgaagca atgtggtcat caaataagtg cttgccatcg 420 agacatttat aaaggagttg atatgagagg agtcaatttt aatgtgtcta aggttagcag 480 tgttgaagaa tgccaaaaaa ggtgcaccag taacattcgc tgccagtttt tttcatatgc 540 cacgcaaaca tttcacaagg cagagtaccg gaacaattgc ctattaaagt acagtcccgg 600 aggaacacct accgctataa aggtgctgag taacgtggaa tctggattct cactgaagcc 660 ctgtgccctt tcagaaattg gttgccacat gaacatcttc cagcatcttg cgttctcaga 720 tgtggatgtt gccagggttc tcactccaga tgcttttgtg tgtcggacca tctgcaccta 780 tcaccccaac tgcctcttct ttacattcta tacaaatgta tggaaaatcg agtcacaaag 840 aaatgtttgt cttcttaaaa catctgaaag tggcacacca agttcctcta ctcctcaaga 900 aaacaccata tctggatata gccttttaac ctgcaaaaga actttacctg aaccctgcca 960 ttctaaaatt tacccgggag ttgactttgg aggagaagaa ttgaatgtga cttttgttaa 1020 aggagtgaat gtttgccaag agacttgcac aaagatgatt cgctgtcagt ttttcactta 1080 ttctttactc ccagaagact gtaaggaaga gaagtgtaag tgtttcttaa gattatctat 1140 ggatggttct ccaactagga ttgcgtatgg gacacaaggg agctctggtt actctttgag 1200 attgtgtaac actggggaca actctgtctg cacaacaaaa acaagcacac gcattgttgg 1260 aggaacaaac tcttcttggg gagagtggcc ctggcaggtg agcctgcagg tgaagctgac 1320 agctcagagg cacctgtgtg gagggtcact cataggacac cagtgggtcc tcactgctgc 1380 ccactgcttt gatgggcttc ccctgcagga tgtttggcgc atctatagtg gcattttaaa 1440 tctgtcagac attacaaaag atacaccttt ctcacaaata aaagagatta ttattcacca 1500 aaactataaa gtctcagaag ggaatcatga tatcgccttg ataaaactcc aggctccttt 1560 gaattacact gaattccaaa aaccaatatg cctaccttcc aaaggtgaca caagcacaat 1620 ttataccaac tgttgggtaa ccggatgggg cttctcgaag gagaaaggtg aaatccaaaa 1680 tattctacaa aaggtaaata ttcctttggt aacaaatgaa gaatgccaga aaagatatca 1740 agattataaa ataacccaac ggatggtctg tgctggctat aaagaagggg gaaaagatgc 1800 ttgtaaggga gattcaggtg gtcccttagt ttgcaaacac aatggaatgt ggcgtttggt 1860 gggcatcacc agctggggtg aaggctgtgc ccgcagggag caacctggtg tctacaccaa 1920 agtcgctgag tacatggact ggattttaga gaaaacacag agcagtgatg gaaaagctca 1980 gatgcagtca ccagcatgag aagcagtcca gagtctaggc aatttttaca acctgagttc 2040 aagtcaaatt ctgagcctgg ggggtcctca tctgcaaagc atggagagtg gcatcttctt 2100 tgcatcctaa ggacgaaaaa cacagtgcac tcagagctgc tgaggacaat gtctggctga 2160 agcccgcttt cagcacgccg taaccagggg ctgacaatgc gaggtcgcaa ctgagatctc 2220 catgactgtg tgttgtgaaa taaaatggtg aaagatca 2258 <210> 33 <211> 1743 <212> DNA <213> KRT37 <400> 33 agtctcagtg gctcagcctt cccagctgat ctgaagctcc tgtgcagcct cagccctaca 60 ccatgacctc cttctacagc acctcctcat gccctctggg ttgcaccatg gctcctggag 120 caagaaatgt ctttgtctct cctatcgatg ttgggtgcca gcctgtggca gaggccaatg 180 ctgcctccat gtgcctcttg gccaacgtgg cacacgccaa cagagtccgt gtggggtcga 240 ctcccctggg ccgccccagc ctctgtctgc ccccaaccag tcacactgct tgtcccttgc 300 cagggacctg tcacattccc ggcaacatcg gaatctgtgg ggcctacggc aaaaacaccc 360 tgaatggcca tgagaaggag accatgaagt tcctgaatga ccgcctggcc aactacctgg 420 agaaggtgcg ccagctggag caggagaatg cagagctgga gaccacactc ctcgagagga 480 gcaagtgcca cgagtccacc gtgtgccccg actaccagtc ctacttccgt acaatcgagg 540 agctccagca gaagatcctg tgcagcaagg ctgagaatgc caggctgatt gtacaaattg 600 acaacgcgaa gctggctgct gatgacttta ggatcaagct ggagagtgag cgctcccttc 660 accagctggt ggaggcggac aagtgcggga cgcagaagct cctggatgac gcgaccctgg 720 ccaaggccga cctggaggcc cagcaggagt ccctgaagga ggagcagctc tccctcaaga 780 gcaaccacga gcaggaagta aagattctga gggatcagct gggggagaag ttccggatcg 840 agctggacat tgagcccacc attgacctga acagggtgtt gggggagatg cgggctcagt 900 acgaggccat ggtggagacc aaccaccagg atgtggaaca gtggttccaa gcccagtctg 960 aaggcatcag cctgcaggcc atgtcctgct ccgaggagct gcagtgctgc cagtcggaga 1020 tcctggagct gagatgcacg gtgaatgccc tggaggtgga gcgccaagcc cagcacacct 1080 tgaaggactg tctgcagaac tccctgtgtg aagcggagga ccgctacggc acagagctgg 1140 cccagatgca gagcctcatt agcaacttgg aagagcagtt gtctgagatc cgggccgacc 1200 tggagcggca gaaccaggag taccaggtgc tgctggacgt gaaggcccgg ttggagaacg 1260 agattgccac ataccggaac cttctggaga gcgaggactg caaactcccc tgcaatccct 1320 gttccacgcc tgcctcctgt acttcttgtc caagctgtgg ccctgtcacc ggtgggtctc 1380 cctctggcca tggagccagc atggggagat gattctgaag gcccgagtta ggagattgag 1440 gctggttgca ctggggtcag gagtgccctc accttgccca gtcttccttc aagactagac 1500 tcactgaggc attttcccta aatcaaccgg tagcagatac ttccaaggag tggctccctg 1560 cctatgcctc taagctgtat tttttgttgt tgctaaaatg ttgtaattat cttccatgaa 1620 agcaattatt tttcctggtg tctcttcttg gtacttttag ttctattcca gtgtttcaga 1680 atctccaaaa atgtaactgg gttccctgca ttaaatggtc aataaacctc cttcctgcac 1740 caa 1743 <210> 34 <211> 2106 <212> DNA <213> LETMD1 <400> 34 ctcttctctc ccgcttctct cgctgtgaag atggcgctct ccagggtgtg ctgggctcgg 60 tcggctgtgt ggggctcggc agtcacccct ggacattttg tcacccggag gctgcaactt 120 ggtcgctctg gcctggcttg gggggcccct cggtcttcaa agcttcacct ttctccaaag 180 gcagatgtga agaacttgat gtcttatgtg gtaaccaaga caaaagcgat taatgggaaa 240 taccatcgtt tcttgggtcg tcatttcccc cgcttctatg tcctgtacac aatcttcatg 300 aaaggattgc agatgttatg ggctgatgcc aaaaaggcta gaagaataaa gacaaatatg 360 tggaagcaca atataaagtt tcatcaactt ccataccggg agatggagca tttgagacag 420 ttccgccaag acgtcaccaa gtgtcttttc ctaggtatta tttccattcc accttttgcc 480 aactacctgg tcttcttgct aatgtacctg tttcccaggc aactactgat caggcatttc 540 tggaccccaa aacaacaaac tgatttctta gatatctatc atgctttccg gaagcagtcc 600 cacccagaaa ttattagtta tttagaaaag gtcatccctc tcatttctga tgcaggactc 660 cggtggcgtc tgacagatct gtgcaccaag atacagcgtg gtacccaccc agcaatacat 720 gatatcttgg ctctgagaga gtgtttctct aaccatcctc tgggcatgaa ccaactccag 780 gctttgcacg tgaaagcctt gagccgggcc atgcttctca catcttacct gcctcctccc 840 ttgttgagac atcgtttgaa gactcataca actgtgattc accaactgga caaggctttg 900 gcaaagctgg ggattggcca gctgactgct caggaagtaa aatcggcttg ttatctccgt 960 ggcctgaatt ctacgcatat tggtgaagat aggtgtcgaa cttggctggg agaatggctg 1020 cagatttcct gcagcctgaa agaagctgag ctgtctctct tgctgcacaa cgtggtcctg 1080 ctctccacca actaccttgg gacaaggcgc tgaatgaacc atggagcgga tggcattgtc 1140 ctgcagtcgt atagtatagc agtgcaggaa caaacagcac ttgccagcaa agtctgtgtg 1200 tactgttaag tgtgtgggag gcagagagag gagcaggggc catgggcttc acagcatggc 1260 acacatgtgg gaactgcaga cattcctctc acagctagaa ctgaaacaaa ccctcttgct 1320 aggggtggtc cgtgtgaggt gtcatcctgt ccccctcata attactaata gctggaactg 1380 gcagcagcct ctactgggct tttactgtga tgtgttcagt tcatgtccta ggaagtcagc 1440 ttttgcccca ggtgggaatc cttatttggc ttaggactga tccacttcca tgttacttac 1500 atctgtgggt ttttgttgtt gctgttagaa aatttgtggc tggtgaaaac agcactcctt 1560 tggctggagc acatgtgtcc gtgcatgtac ttgggtgttt ccctccatcc tttctgatat 1620 gaccaaaaat caagttgttt tgttttttgt caccttcact ggcatgggct aaccacttct 1680 ttttcaaacc ctctgaacac ctttttctga tgggtaactt gcaggaatat tctattggaa 1740 aagataacag gaagtacaag tgcttcttga ccccttcctc aatgtttcta gccttcactc 1800 tccattgtct tttctgggct gtattacagc cctctgtgga tcttcaactc tgctgcctcc 1860 actgtgatgc agcagtccaa ctgtaactga cagtggctgc cttctctggg ccatggatca 1920 cacctgtaag gtactaatta ctgcccagcc tggggagatc aggagaggtc tgcatagtta 1980 gtaagttggg tttagctttt gtgtgtgcat cagtgactta gagttctgta ataacttatt 2040 gtaaatgcat gaagcactgt ttttaaaccc aagtaaagac tgcttgaaac ctgttgatgg 2100 aaatga 2106 <210> 35 <211> 7121 <212> DNA <213> MAML2 <400> 35 actctctctc tttctctccc tctcctatcg gagcacaatg aaagcctgtg tatcgccgtg 60 actccgggcg cgagccagtg tcagcaaagc ggctaacaac agacgagaaa gagaaaggaa 120 aatacaagct actttttttt tccatctata aagcggagca aatacaggag atagaaccag 180 attgcttatt gcgagtccag accctcagat ccactggccg gggatggaat gtacaaaagt 240 ggacagaaaa gtggctggac atgactcggt gcaatttgct ggaagtttgt aagtttgacc 300 atcgtttgta aattactctc ggaagagttt gtctctcttg atactgtatt agaatagagc 360 cgggggtgag gaatagaaac gtaagcggga aagaaaaaaa tgtgttgaag gatctctctc 420 agtggctagc gacttaagat tgcttttcat ttaaggctag gaaaccttag agggagtgag 480 gattttaccg gtgattggat tagctgaaga aaaaagcatg gtccaaaagt ccaattactg 540 acattgttaa cagttgaaaa gctgtctccc tcttttggga gaagacaaca tcctacagta 600 ccccaaagag gagaaaacac cggagcgaaa ggaaagggag gaaaaattaa aagccaaaag 660 acagtctccc ttgatttttg cacattttga acagtgactt aaacatcttc tgaaacagca 720 ctgttttgtt ttgttttggt tttttattta acctgaggaa aagtcaaggc tgctggttac 780 atagacatgg tagaaatgtg tttctctgca gaaacatccc cataaagaat tgtcggaaac 840 aactaggtga gggggagtcc tctctattataa tacctctctc aatacctttt gctgtgtgtt 900 tctgtctctt gctggacaat ccctgaattc ttgatctaac ccccagatcg tgtgtttaca 960 aagtacctag tggctcttgt cagcttggtg gaggaaaaaa aatccaccaa ctctgtccaa 1020 cttctccaga gctgtcaaat gcaattagag taagttaatc agggtttgtt tccaacttat 1080 cctcccccca gttggtttct attctttctc cccaccctct ttttactaac tcccctcccc 1140 cacaacttct ccacggctcc cccacaacct ctgaagacct ctattcatgt ggccctgaac 1200 actgagctca cattgtcaaa aacagacttg cctgcaatag ccagcagtag cctctttcca 1260 cctcaccatc ccagaggcag caatcattgt gtccggtaag atgggggaca cagcgccccc 1320 gcaggccccc gcaggagggc tagggggggc ctctggggcg gggctccttg gagggggctc 1380 agtcaccccg agagtgcaca gtgctatcgt ggagcgcctc cgggctcgga tcgctgtctg 1440 ccgccaacac cacctgagct gtgaaggacg atatgaacga ggtagggccg agagctcaga 1500 ccgggaaaga gaaagcacct tgcagctcct gagccttgta cagcatggcc aggggggcaag 1560 gaaagctggc aaacacacca aggccaccgc cactgctgcc accactacag cccctccacc 1620 gccccctgct gcccctcctg cggcctccca agcagcagca acagcagccc caccgccccc 1680 accagactat caccatcacc accagcagca cctgctgaac agtagcaata atggtggcag 1740 tggtgggata aacggagagc agcagccgcc cgcttcaacc ccaggggacc agaggaactc 1800 agccctgatt gcgctccagg gttccttgaa aagaaaacag gtagttaacc tatctcctgc 1860 caacagcaag cgacccaatg gctttgtgga caactcattt cttgatatca aaagaattcg 1920 tgttggggag aatctctctg caggacaagg tggcctccaa ataaacaatg gacaaagtca 1980 gattatgtca gggaccttgc ctatgagcca agcacccctg cgaaagacta acactctgcc 2040 atcccataca cattctcctg gcaatggcct gtttaacatg ggcttaaagg aggtaaagaa 2100 ggagccagga gagactctgt cttgcagtaa gcacatggat ggccaaatga cccaagagaa 2160 tatttttcct aataggtacg gagacgaccc tggagaacaa ctgatggatc ctgagctgca 2220 ggaactgttc aatgaactga ccaacatatc tgtgcctccc atgagtgacc ttgaactgga 2280 gaacatgatc aatgccacca taaagcagga tgacccattt aacattgact tgggtcagca 2340 aagccagagg agcacaccta ggccctcctt acccatggag aaaatagtga tcaaaagtga 2400 atactcaccg ggcttgactc agggcccctc aggctctcct cagctgaggc ccccatcagc 2460 tggccccgca ttctccatgg ccaactctgc cctctccact tcgtctccaa tcccttcagt 2520 ccctcagagc caggctcagc ctcagacagg ctccggagca agccgggcct tgccaagctg 2580 gcaggaagta tcccatgccc agcagctcaa acagatagct gctaatcgtc agcagcatgc 2640 ccggatgcag cagcaccagc agcagcacca gcctaccaac tggtcagcct tgccctcttc 2700 tgctggacca tcaccaggtc catttgggca ggagaaaatc cccagccctt cttttggtca 2760 gcagacattc agccccacaga gctcccccat gcctggggta gctggcggca gcggccagtc 2820 gaaagtaatg gctaactaca tgtacaaggc cggcccctca gcccagggtg ggcacctaga 2880 tgtcctcatg cagcaaaagc ctcaggatct cagtcgaagt tttattaaca acccgcaccc 2940 agccatggag ccccgtcagg gcaacaccaa gcctttgttt cattttaact cagatcaagc 3000 gaaccagcag atgccttctg ttttgccttc ccagaacaag ccttctctcc tacactacac 3060 ccaacagcaa cagcagcaac agcagcagca gcagcagcag cagcagcagc agcagcagca 3120 acagcagcag cagcagcaac agcaacagca acagcaacag cagagttcaa tttcagctca 3180 acaacagcaa cagcagcaga gctcaatttc agcccaacag cagcagcagc agcaacaaca 3240 gcagcagcag cagcaacaac aacagcaaca acagcagcag cagcagcagc aacaaccatc 3300 ttctcagcct gcccaatctc taccaagcca gcctttgcta aggtcacctt tgccacttca 3360 gcaaaagctc ctacttcagc aaatgcagaa tcagcccatt gcaggaatgg gataccaagt 3420 ctcccaacaa cagagacagg atcaacactc tgtggtaggc cagaacacag gccccagtcc 3480 aagtcctaac ccctgctcaa atccaaacac tggaagtggt tacatgaact cccagcaatc 3540 actgttgaat cagcaattga tgggaaagaa gcagactcta cagaggcaga tcatggagca 3600 gaaacagcaa cttcttctcc agcagcagat gctggctgac gcggagaaaa ttgctccaca 3660 agatcagata aaccgacatt tgtcaaggcc acctccagat tataaagacc aaagaagaaa 3720 tgtgggcaat atgcaaccaa ctgctcagta ttctggtggc tcatccacaa taagcttaaa 3780 ctctaaccag gctttggcaa acccagtttc aacacacacc attttaactc ccaattccag 3840 cctcctgtct acttctcacg ggacaagaat gccatcatta tctacagcag ttcagaatat 3900 ggggatgtat ggaaatctgc cttgtaatca acctaacaca tacagtgtca cttcaggaat 3960 gaatcaattg acccaacaga gaaacccaaa gcaattgtta gcaaatcaaa acaaccctat 4020 gatgccacgg ccacctacct tagggccaag taataataac aatgtagcca cttttggagc 4080 tggatctgtt ggtaattcac aacaattgag accaaattta acccatagta tggcaagcat 4140 gccaccacag agaacatcaa acgtaatgat cacatccaac acaactgcac caaactgggc 4200 ctctcaagaa ggaacaagca aacagcaaga agccctgacg tctgcaggag tccgcttccc 4260 cacaggtaca cctgcagcct ataccccaaa tcagtcactg caacaggcag taggtagcca 4320 gcaattttcc cagagggcag tggctcctcc taaccagtta acaccagcag tgcaaatgag 4380 acccatgaac caaatgagcc aaacactaaa tgggcaaacc atgggtcccc tcaggggtct 4440 gaatctcaga cccaatcagc taagcacaca gattttgcct aatttgaatc agtcaggaac 4500 agggttgaat cagtcgagga cgggcatcaa ccagccacca tccctgacgc ccagcaattt 4560 tccttcaccc aaccaaagtt ccagggcttt tcaaggaact gaccacagca gtgacttagc 4620 ttttgacttc ctcagccaac aaaatgataa catgggccct gccctaaaca gtgatgctga 4680 tttcattgat tctttattga agacagagcc tggtaatgat gactggatga aagacatcaa 4740 tcttgatgaa atcttgggga acaattccta aagaagaaag ggaagacaat ttacaaactc 4800 caagcactaa aaggcagtat attacagaaa ctctgtagag gctgaactgt tgatgttcag 4860 gtggactaca tgaagataac atgcttaaaa atggaaagca gaaagtaact gcagtgatga 4920 acattttggt ccaaattctt gttttaaatc ttacacctga aagtaaaata ttgggatcac 4980 ttttccctgt ctaaactcca ggatacagta tccaatttat ccaaacagaa ctgtggtgtc 5040 aatgtgtaat taattgtgta aaatagcctt cccaagtttc tttttccctg gaaaataaaa 5100 aaggtaatag aacttgtagt ttatttaaac cccatgtcat gaggaggtac tagttccaag 5160 caacaaactc cttaatttgc tctaatagat aggtatggtt taatctttcc attgtgtctt 5220 ttcatttaat tttcctgaag cttgcaggat agattgaaat gttataggtt tgtttggagt 5280 aaccaaacag tatgcaaatt aagaaaaagc cagagaacct agaaaacatc cagtggatta 5340 cagaatttct tccccatatt cactcctcac ttttacaatt ttcccacaat cctctacttc 5400 agtgggatgc tgtgtctagt gattaaacaa aaatatagag ctgtgcaatt tgattttggc 5460 ttccacaacg aatatctgaa tccattccaa atgaaatttt agatataaca aagacttgtc 5520 ctaatcatac tgaaatattg gtgcacacct ctctgcatta gatttcactt ttttaaaaaa 5580 cccagtggac attgctataa ataagattta tttggctaca aataacctgg gatgttgctt 5640 attatgattg atgcctgctg gtttgttccc aagctgagtg aaattgaacc tcgtcctccc 5700 tactcatttt gatgactgag gctggtttat aagaaaagga agtttggaga agaaaaccga 5760 gattagaaaa tatcatgttt tggttggaga taagaaccag ggatggcaag taccagtgtg 5820 tacaaatgta tttcacggag tttgaaggaa cgcataatca agagggaaaa caatttgtcc 5880 ttcattggac gtattatttg gatttgggtg agcaacaaaa tggaatgtgg tctgttagga 5940 gcattctgtt tgttcttttg tccctgatgt gatgaatcat tgccacatgc tagatggact 6000 cttcatatcc aggttttgtc cctcagggct gagcactgta ttaaagagtt tttgttgagt 6060 catttaacct tagtgtccac atccagatca gctgtaaaat ggggaagacg tgtgctgatt 6120 tggaatgaat gcaaaatatc actatcattt tcctaattac agaggagcaa aggttatctt 6180 cagccctttc agttctatgc tcacatattc aaatatcaaa tgtaatttag ctgaagttat 6240 ttaataatca agtctttcaa tatctgttca aagaaaaaga acacactttg aaaattctgc 6300 aaagctgtct cccagtcttt aaaatgtctg gaagcactct ccttctttac aataccaaca 6360 tcactggccc agaatcttcc ctgtgctagt ttgtaaatat aaataaatta cttgttttgt 6420 aaacttttgt aaagaatatt ttggtagaaa tacttcaaac atattctttg ggttatattt 6480 atacatatgt gaaataaata tactatcaaa aggttatatt ttatacaaaa agtaaattgc 6540 taccttttgt atgctaatat gcaaagtttt gtataatatg atggtttatt tttagctcta 6600 cacttaaacc ataggtggtt gagtgggaac ttttgaaaac tatcaagagg cttgttagac 6660 aaatttatat tctgaaacct caataagaaa gcattccagg tttcaatcct tgttttttgt 6720 cctgctccca aattcttttt taaacccata gttcttgtgt cttatttgat tcttctgctg 6780 tgcacattgt attggtcctt gttgcatgta gtctactgtg tgttttccga ttttataagg 6840 cagcatttct ccatacaaaa agaaaaaaaa tgatgtacat ataaacgctt ttgttgtatg 6900 gctcctccat gttactgtat atatctgcca gcacttccca gttacactcc tgtgagtcag 6960 cttattttta ccctaacata aatagtatgt tttgtagtag ttatcaaatt taagagataa 7020 agcaatcaga atgtttggat tttcttctat cttaatgtga atttcataat taatgtctat 7080 ttattcagct attcattaaa atacaggatt ctttgggaaa a 7121 <210> 36 <211> 11790 <212> DNA <213> MAP1B <400> 36 gcagtggaga ggagcggccg gagcgagaca cttcgccgag gcacagcagc cggcaggatg 60 gcgaccgtgg tggtggaagc caccgagccg gagccgtccg gcagcatcgc caacccggcg 120 gcgtccacct cgcctagcct gtcgcaccgc ttccttgaca gcaagttcta cttgctggtg 180 gtcgtcggcg agatcgtgac cgaggagcac ctgcggcgtg ccatcggcaa catcgagctc 240 ggaatccgat catgggacac aaacctgatt gaatgcaact tggaccaaga actcaaactt 300 tttgtatctc gacactctgc aagattctct cctgaagtcc caggacaaaa gatccttcat 360 caccgaagtg acgttttaga aacagtggtc ctgatcaacc cttctgatga agcagtcagc 420 accgaggtgc gcttaatgat cactgatgct gcccgacaca agctgctcgt gctgaccggg 480 cagtgctttg aaaataccgg agagctcatt ctccagtccg gctctttctc cttccagaac 540 ttcatagaga ttttcaccga tcaagagatc ggggagttac taagcaccac ccatcctgcc 600 aacaaagcca gcttaaccct gttctgtcct gaagaagggg actggaagaa ctccaatctt 660 gacagacaca atctccaaga cttcatcaat attaaactca attcagcttc tatcttgcca 720 gaaatggaag gactttctga gtttaccgag tatctctcag aatcagtgga agtcccatct 780 ccctttgaca tcttggaacc tcccacatcg ggtggatttc tgaagctctc caagccctgc 840 tgttatattt ttccaggagg gaggggcgat tctgccttgt ttgcagtgaa tggtttcaat 900 atgctcatca atggcggatc agagagaaaa tcctgcttct ggaagctcat ccgacactta 960 gaccgagtgg actccatcct gctcacccac attggggatg acaatttgcc tggaataaac 1020 agcatgttac agcggaaaat tgcagagctc gaggaagaac agtcccaggg ctccaccaca 1080 aatagtgact ggatgaaaaa cctcatctcc cctgacttag gagttgtatt tctcaatgta 1140 cctgaaaatc tcaaaaatcc agagccaaac atcaagatga agagaagcat agaagaagcc 1200 tgcttcactc tccagtacct aaacaaattg tccatgaaac cagaacctct gtttagaagt 1260 gtaggcaata ctattgatcc tgtcattctt ttccaaaaaa tgggagtagg taaacttgag 1320 atgtatgtgc ttaatccagt caagagcagc aaggaaatgc agtattttat gcagcagtgg 1380 actggtacca acaaagacaa ggctgaattc attctgccta atggtcaaga agtagatctc 1440 ccgatttcct acttaacttc agtctcatct ttgattgtgt ggcatccagc aaaccctgcg 1500 gagaaaatca tccgagtcct gtttcctggg aacagcaccc agtacaacat cctggaaggg 1560 ttggaaaagc tcaaacatct agactttctg aagcagccac tggccaccca aaaggatctc 1620 actggccagg tgcccactcc tgtggtgaaa caaacaaaac tgaaacagag ggctgatagc 1680 cgagaaagtc tgaagccagc cgcaaaacca cttcctagca aatccgtgcg caaggagtca 1740 aaagaagaaa cccctgaggt cacaaaagtg aatcacgtgg aaaagccacc caaagttgaa 1800 agcaaagaaa aggtaatggt gaaaaaagac aagccaataa aaacagagac caaaccttca 1860 gtgactgaaa aggaggttcc cagcaaagaa gagccatctc cagtgaaagc cgaggtggct 1920 gagaagcaag ccacagatgt caaacccaaa gctgccaagg agaagacggt gaaaaaggaa 1980 acaaaggtaa agcctgaaga caagaaagag gagaaagaaa agccaaagaa agaagtggct 2040 aaaaaggagg acaaaacacc tatcaagaag gaggaaaaac caaaaaagga agaggtgaaa 2100 aaagaagtca aaaaagagat caagaaagaa gagaaaaaag aacccaagaa agaggttaag 2160 aaagaaacac cgccaaagga agtcaagaag gaagttaaga aggaagagaa gaaggaagtg 2220 aaaaaggaag aaaaggaacc caaaaaagaa attaagaagc tccctaaaga cgcaaagaaa 2280 tcatctactc ctctgtctga agcaaaaaaa ccagctgctt taaaaccaaa agtacccaag 2340 aaggaagagt ctgtcaagaa agattctgtt gctgccggaa agccaaagga gaaggggaaa 2400 ataaaagtca ttaagaagga aggcaaggcc gcagaggctg tcgctgcagc tgtcggcact 2460 ggagccacca cagcagctgt catggcggca gctggaatag cagccattgg ccctgccaaa 2520 gaactcgaag ctgagaggtc ccttatgtca tctcctgagg atctaaccaa ggactttgaa 2580 gagttaaagg ctgaagaggt cgatgtaaca aaggacatca agcctcagct ggagctaatc 2640 gaagacgaag agaaactgaa ggaaactgag ccagtcgaag cctacgtcat ccagaaggag 2700 agagaagtca ccaaaggtcc tgccgagtcc cctgatgagg gaatcactac cactgaaggg 2760 gagggcgaat gtgaacagac acctgaggag ctggagcccg tcgagaagca gggagtagac 2820 gacattgaaa aatttgaaga tgaaggagcc ggttttgaag aatcttcaga gactggagac 2880 tatgaagaga aggcagaaac tgaggaggct gaggagccag aagaggatgg ggaggaacac 2940 gtatgtgtga gcgcctccaa gcacagcccc actgaggatg aggaaagtgc caaggcggag 3000 gctgatgcat acatcaggga gaagagggag tctgtggcca gtggggatga ccgagccgaa 3060 gaagacatgg atgaggccat tgagaaagga gaggctgaac aatctgaaga ggaggctgat 3120 gaggaggaca aagctgaaga tgccagagag gaggaatatg agccggaaaa aatggaagct 3180 gaagactatg tgatggctgt ggtcgacaag gctgcagagg ctggtggtgc cgaggagcag 3240 tatggattcc tcaccacacc aaccaagcaa ctaggagccc agtctcctgg ccgagaacct 3300 gcatcttcaa ttcatgatga gactttacct ggaggctcag agagcgaggc caccgcttct 3360 gatgaggaga atcgagaaga ccagcctgag gaattcactg ccacctctgg ctacactcag 3420 tctactattg agatatccag tgagcccacc cccatggatg agatgtctac ccctcgagac 3480 gtgatgagtg atgagaccaa caatgaagag acggagtccc cttctcagga attcgtaaat 3540 atcaccaaat atgaatcttc attgtattct caggaatact ctaaacctgc tgatgttaca 3600 ccgctcaacg gattttctga aggatcaaaa acagatgcca ctgatggcaa ggattacaat 3660 gcttcagcct ctaccatatc accaccctct tccatggagg aagacaaatt cagcagatct 3720 gctttacgtg atgcttactg ctctgaagtg aaagccagca ccactttgga catcaaagat 3780 agcatctcag ctgtttcaag tgaaaaggtc agcccatcga agagcccgtc cctgagtcca 3840 tctccaccat cacccttaga aaagaccccc ctgggtgaac gtagtgtgaa cttctctctg 3900 acgcccaatg agattaaagt ctctgcagag gcagaagtag ccccggtgtc tcctgaggtg 3960 acccaagaag tagttgaaga acatgtgct agtcctgagg acaagactct ggaagtggtg 4020 tcaccatctc agtccgtgac tggcagtgct ggtcacacac cttactatca atctcctact 4080 gacgagaaat ccagtcatct ccctacagaa gtcattgaaa aaccaccagc agttccagtg 4140 agttttgaat tcagtgatgc caaagatgag aatgaaaggg cttcagtaag ccccatggat 4200 gagcccgtgc ctgactcaga gtctcctatt gaaaaagttt tgtctccttt acgcagcccg 4260 cccctcattg gatccgagtc tgcttatgaa agttttctaa gtgctgatga caaggcttct 4320 ggcagaggtg ccgaaagtcc ttttgaagaa aagagtggaa aacaaggctc tccagaccaa 4380 gtaagtccag tttctgaaat gacttctact agtctttacc aagacaaaca ggaagggaaa 4440 agcacagact ttgcaccaat aaaagaagac tttggccaag aaaagaaaac tgatgatgtt 4500 gaagccatga gttctcaacc agcactggct ctggatgaaa ggaaattag agatgtttct 4560 cccacacaaa tagatgtcag tcagtttgga tcttttaaag aagacactaa gatgtccatt 4620 tctgaaggta ctgtctcaga caagtcagct actcctgttg atgagggcgt agcagaagac 4680 acgtactctc atatggaggg tgtggcctca gtgtccacag cctcagtggc tacgagctca 4740 tttccagagc caacaacaga tgatgtgtct ccatctctgc atgctgaggt tggctcccca 4800 cattccacag aagtagatga ctccctttca gtgtctgttg tgcaaacacc taccacattc 4860 caggaaacag aaatgtctcc atctaaagaa gaatgcccaa gaccgatgtc aatttctcca 4920 ccagatttct cccctaaaac tgcaaagtcc aggacacccg ttcaagatca cagatctgaa 4980 cagtcctcaa tgtctattga atttggccaa gaatctcctg agcaatccct tgctatggac 5040 ttcagtcgac agtctccaga tcaccctaca gtgggtgcag gcgtgcttca catcactgaa 5100 aatgggccaa ctgaagtgga ctacagtcct tctgacatgc aggactccag tttatcacat 5160 aagataccac ctatggagga gccgtcctac acccaagata atgatctttc tgagctcatc 5220 tcagtatctc aggtagaggc ctccccgtcc acctcttctg ctcatacccc ttctcagatc 5280 gcttctcctc tccaagaaga tactctatcc gatgttgctc ctcccagaga tatgtcctta 5340 tatgcctcac tcacctctga aaaagtgcaa agtctggaag gagagaagct ctctccaaaa 5400 tctgatatct ctccactcac cccacgagag tcctctcctt tatattcacc tactttttca 5460 gattctacct ctgcagtcaa agagaaaaca gcaacttgcc acagttcctc ttctccacca 5520 atagatgcag catccgcaga gccctatggc ttccgtgcct cagtgttatt cgatacaatg 5580 caacaccatc tagccttgaa tagagatttg tccacacctg gcctggagaa ggacagtgga 5640 gggaagacac ctggtgactt tagctatgcc tatcaaaagc ctgaggaaac aaccaggtcc 5700 ccagatgaag aagattatga ctatgagtct tatgagaaga ccacccggac ctcagatgtg 5760 ggtggctatt actatgagaa gatagagaga accacaaaat ctccaagtga cagtggctac 5820 tcctatgaga ccattgggaa aactaccaag acccctgaag atggtgacta ttcctatgaa 5880 attattgaga agaccacacg gacccctgaa gagggtgggt actcatatga cataagtgaa 5940 aagaccacca gcccccccga agtgagtggt tacagctatg aaaagactga gaggtctaga 6000 aggcttctgg atgacatcag caatggctat gatgactctg aggatggtgg ccacacactt 6060 ggggacccca gctactctta tgaaaccact gagaaaatta ccagtttccc tgagtctgaa 6120 ggttattcct atgagacatc tacaaagaca acacgaaccc ctgatacttc cacatactgt 6180 tacgagactg cagagaaaat cactagaacc cctcaggcat ccacatattc ctacgagact 6240 tcagacctat gctacactgc agaaaagaag tccccctcag aagcccgtca ggatgtcgat 6300 ttatgcctcg tgtcctcttg tgaatacaag caccccaaga cagagctttc accctctttc 6360 attaatccca atcctcttga gtggtttgcc agtgaagaac ccactgaaga atctgaaaag 6420 cccctcactc aatcaggggg agccccaccg cctccaggag gaaagcaaca gggccgacag 6480 tgtgatgaaa cccctcccac ctcagtcagc gagtcagccc catcccagac cgactctgat 6540 gttccccccgg agactgaaga gtgcccctcc atcacggccg atgccaatat cgactctgaa 6600 gacgagtcgg aaaccatccc cacagacaaa actgtcacgt acaaacacat ggacccacct 6660 ccagctcccg tgcaagaccg cagcccttcg ccacgccacc ctgatgtgtc catggtggac 6720 ccagaggcct tggccattga gcagaacctg ggcaaagctc taaagaaaga tctgaaagag 6780 aagaccaaaa ccaaaaagcc aggtacaaag accaagtcat cttcacctgt caaaaagagt 6840 gatgggaagt ctaagccctt ggcagcttca ccaaaaccag cgggcttgaa agaatcctcg 6900 gataaagtgt ccagggtggc ttctcctaag aagaaagaat ctgtggaaaa ggcagcaaaa 6960 cccaccacca ctcctgaggt caaagctgca cgtggggaag agaaagacaa ggagaccaag 7020 aatgctgcca atgcctctgc atccaagtcg gccaagaccg ccactgcagg accaggaact 7080 accaagacga ccaagtcatc tgctgtgccc ccaggcctcc ctgtgtattt ggacctgtgc 7140 tacattccta accacagcaa tagtaagaat gttgatgtgg aatttttcaa gagagtgcgg 7200 tcttcctact acgtggtgag tgggaatgac cctgctgctg aggagcccag ccgggctgtc 7260 ctggacgctt tgttggaagg aaaggctcag tggggcagca acatgcaggt gacactgatc 7320 ccaactcatg actcagaagt gatgagggaa tggtaccagg agacccatga gaaacagcaa 7380 gatctcaaca tcatggtttt agcaagcagc agcacagtgg ttatgcaaga tgaatccttc 7440 cctgcatgca agattgaact gtaaaaacca aggccagcca caccacagga tctgaacttt 7500 gtttccagaa attcttcaat ttgaaatcac cttttctaaa aagtcaattc atctagttaa 7560 gtcgctgaac aattacctgc caaatgctat actgtgtcat ggtgatgcaa gtcactaaat 7620 ttctcagttt ttgctgattg ctaagggaaa taacagtatt tccacaatag ggttcaaatt 7680 cctgcaaaat tacctacccc agttcatctc tgctgaacat ttggaaacca tgcactagcc 7740 aacccaactg acttctgcta ggtagaggca tttgtcttag agagagagag agcgcgggag 7800 agagtgagag agagtgagag cacaaagata acgcaggaga gagagagaga aagaatgaga 7860 aagaaaagga atgcaagaga aggagatgta atgacagaga gttctggtga gatacccaga 7920 gagaaaaaga gagagcaggg tggggtaagg aggagaaaat aaaccaacaa ttaggtctgc 7980 attttctcag gcagtaggca ttctttagtc tacataggca aagttttcca tttttgtcag 8040 tctgagtcat caaaaagagt cttaattttc taaaacaagt tggctagaag aaagtaaaaa 8100 gaacaacact tgttatgagg gcatgtgata ttttcacatc ttaattaagc tccttcagtt 8160 tgaaggctgc acactgacat aatgtagtga gtgtagactg gccatgcaag tggtttgggc 8220 cccattcaga actctcagac tctaaacaca caagtagatt gatctaaggc atgctcccag 8280 catttgtcca cccacttagt ccactctgag tcgattaacc tgcatgcagc aacacccaag 8340 tccaccccaa ttaactgaag caaataccaa agcagttggg agtacatatg gtagacaatt 8400 tgccttagga agtgacttga atgtacaaag atacttgatg cacttatttt ttaatgtgag 8460 acagcaagtt tataaaacat ccatatagga ttatagatac ttaaaggaac acgtgggtga 8520 gcgtgtgtgg gggtactaga agctgatctg attggtccaa cagtttgatg ctgagtcatg 8580 cgtgttgaat cccacttcag tgcacctgtg gcctctcagt caaacaagtt gtgcctttca 8640 cagcttcttt actactgcaa gttcaagact gaaatggctt ctatgatcag aactgggaaa 8700 acagtgaatc ttatggtgga agaggttctc agcaagtgta cagtatttac cttcctttgt 8760 cttacattgg ctttttaaat tttccattaa tttcaacata attatgggaa caagtgtaca 8820 gaagaatttt ttttttaaga tatgtgagaa cttttcatag atgaactttt taacaaatgt 8880 tttcatttac aggaaattgc aaagaaaatt ctcaagtgat agtctttttt tttaagtgtt 8940 tcgtaagaca aaaattgaat aatgtttttt gaagttctgg caagattgaa gtctgatatt 9000 gcagtaatga tatttattaa aaacccataa ctaccaggaa taatgatacc tccccacccct 9060 tgattcccat aacataaaag tgctacttga gagtggggga gaatggcatg gtaggctact 9120 tttcagggcc ttgacaagta catcacccag tggtatccta catacttctt tcaagatctt 9180 caaccatgag gtaaaagagc caagttcaaa gaaccctagc acaaatttgc tttgggattt 9240 tcttttctgg aaaaaaaaaa taaaagaaat agtacattga aaacaaatga attctcaact 9300 cctacggttc atgtagagtt tagagaaaat ttccatcatt gtcatcattg aactgtgaac 9360 ctgggaagcc agatcatgat taacactgac atcaagtttc aagttgcaga tcaatgcacc 9420 cagtgttcag atgaggcaaa cttctccgtg acaactgtgc tgtgctctgt cacattacat 9480 ttcctgcaga ctctaagatc tacggagtag agaacaatga cctcatttta ttttctatgt 9540 tagttattta tttcaaaatt aacattttag ttgatttttg tctgataagt ctatgttttg 9600 cactgctaac tatgatgagg gtttaaaaaa atgcttcttc agggtccttt cactgaggac 9660 ctatgcagtc tacttaatgc tgtgaattac atttttcaaa tgtttaattt tttaaagaaa 9720 attaatattc tatttttgtt aggcttctct agaaatgcag cttttattta ttaccccatt 9780 tctttcaagt ccttggaaaa taacatatta agggtacaag aaattaacac atgatggaaa 9840 agtcattgtg acgccaatga atttcattga gtataaactc atctacttca aatttatttt 9900 ataacacaac ctaagatact caagataatt atttaatggt tagctcttaa gttgaattgg 9960 tctacataat gcgtgggaag aaaaccagat ttttagcctt cttgccaaat ccagacctct 10020 ggttgatttt tctttgacag aagatgcaag ttattttcca atttcacaat taaatgtatt 10080 taacctgaac attattttgc tttaaaaact ataaacattg taggagaatt atagccagtc 10140 ttcagttata accactccac cctcctcact ttctctctct ctctctcttt tttttttttt 10200 ttttttttgc tatgggattt aatgggaaaa atatgtaaaa actgtcacta gtcagctggc 10260 tctttttcct atgaaatcta tcagtacctt tctccatccg ttgttctcaa tatgaccaca 10320 gagcctgagt ataccaagaa aaccaatatt cgcattacag gttgctcctg tccttccaga 10380 cacctttcct gcctgtgtga ctaacctaat tttgctagtt ccataaatac acgattagtt 10440 tagtaacagc catcacaatg taccatgtac attcatggtg agagctaaag atcgacacag 10500 acttctagga gctttgttca tactgattac ttaatccaat tgtatagatt gaatatttga 10560 gtggaaggaa tttacactct gtttaaatga tgggattcta tcgagatagc actcatgatc 10620 atgacctttt tggtagtatt cttaaacaaa attctacaga gactaaatgt tagcgatgat 10680 cctccatttt caattttaac caattctgtc ccctttctca aaaccctgag ccctgtgcat 10740 gctttctcag tcttgtggtg ggactggata caatgactaa cttcccctcc tcccctcttt 10800 aaacaccatt ttccatggag ttcaaaaaaa ttttttttct taacgttaca tatcatagtg 10860 aatggtttcc ccagtgtata tgaatgtttt aagtgtctcc aatagcttat gcagtctagg 10920 agctttccaa tactcattta attaagattt aatcatttgc taatggaaat cttaccacct 10980 ttcattttcc ctctgttacc aaatttcagc tcttaggagc tgctctacaa ttctgaattt 11040 gcttttcttg cctctcttta gtcacctgtc acaggaggtt cctgctcagt aatgatattg 11100 tgagttagga taataacttt ttttttttgt gcttcagatt tagaagaaaa gatcctgttt 11160 ccatttgaaa ggaactgtaa gcttttatct tttaaccaac tgaacaatac accaaaagca 11220 gcctagggat gagcatttct ttgaaagcaa ttaggttatt cacctggtat taaaactatt 11280 tactgttaaa aaatctgtga cttcatgaag ttgattttta aaggcagcat caaaaactga 11340 aaaggaaggg aaaaaatagg cagcttctct gcacttgttt ggagctcccc aaaacaggag 11400 ccatggagaa gtggcatcaa gaccgggctg ccctttcgag aacaccctgt ggcagttcag 11460 agacacgctt ttcctacact gcatgcagcc cctctttcca gcactggaaa gaagtggtct 11520 tgagcccagc tgagaagcac ttcacactcc tctctcttgt tctgaatggt gtttgtgtca 11580 gtctgcagct gtgtatggta ttatgtctta taatcctgca tcacttctat cctatccagt 11640 catatctaat gtagaaaatt agtttccagt gaaagtaata tgtagtgctt ttatgatatt 11700 tgtgtgcaat atcccctctt ccattgagga tatttgatgt aaaggaaaaa aaaaaactca 11760 gttccacaat aaaatacaaa agtggcaaaa 11790 <210> 37 <211> 11790 <212> DNA <213> METTL9 <400> 37 gcagtggaga ggagcggccg gagcgagaca cttcgccgag gcacagcagc cggcaggatg 60 gcgaccgtgg tggtggaagc caccgagccg gagccgtccg gcagcatcgc caacccggcg 120 gcgtccacct cgcctagcct gtcgcaccgc ttccttgaca gcaagttcta cttgctggtg 180 gtcgtcggcg agatcgtgac cgaggagcac ctgcggcgtg ccatcggcaa catcgagctc 240 ggaatccgat catgggacac aaacctgatt gaatgcaact tggaccaaga actcaaactt 300 tttgtatctc gacactctgc aagattctct cctgaagtcc caggacaaaa gatccttcat 360 caccgaagtg acgttttaga aacagtggtc ctgatcaacc cttctgatga agcagtcagc 420 accgaggtgc gcttaatgat cactgatgct gcccgacaca agctgctcgt gctgaccggg 480 cagtgctttg aaaataccgg agagctcatt ctccagtccg gctctttctc cttccagaac 540 ttcatagaga ttttcaccga tcaagagatc ggggagttac taagcaccac ccatcctgcc 600 aacaaagcca gcttaaccct gttctgtcct gaagaagggg actggaagaa ctccaatctt 660 gacagacaca atctccaaga cttcatcaat attaaactca attcagcttc tatcttgcca 720 gaaatggaag gactttctga gtttaccgag tatctctcag aatcagtgga agtcccatct 780 ccctttgaca tcttggaacc tcccacatcg ggtggatttc tgaagctctc caagccctgc 840 tgttatattt ttccaggagg gaggggcgat tctgccttgt ttgcagtgaa tggtttcaat 900 atgctcatca atggcggatc agagagaaaa tcctgcttct ggaagctcat ccgacactta 960 gaccgagtgg actccatcct gctcacccac attggggatg acaatttgcc tggaataaac 1020 agcatgttac agcggaaaat tgcagagctc gaggaagaac agtcccaggg ctccaccaca 1080 aatagtgact ggatgaaaaa cctcatctcc cctgacttag gagttgtatt tctcaatgta 1140 cctgaaaatc tcaaaaatcc agagccaaac atcaagatga agagaagcat agaagaagcc 1200 tgcttcactc tccagtacct aaacaaattg tccatgaaac cagaacctct gtttagaagt 1260 gtaggcaata ctattgatcc tgtcattctt ttccaaaaaa tgggagtagg taaacttgag 1320 atgtatgtgc ttaatccagt caagagcagc aaggaaatgc agtattttat gcagcagtgg 1380 actggtacca acaaagacaa ggctgaattc attctgccta atggtcaaga agtagatctc 1440 ccgatttcct acttaacttc agtctcatct ttgattgtgt ggcatccagc aaaccctgcg 1500 gagaaaatca tccgagtcct gtttcctggg aacagcaccc agtacaacat cctggaaggg 1560 ttggaaaagc tcaaacatct agactttctg aagcagccac tggccaccca aaaggatctc 1620 actggccagg tgcccactcc tgtggtgaaa caaacaaaac tgaaacagag ggctgatagc 1680 cgagaaagtc tgaagccagc cgcaaaacca cttcctagca aatccgtgcg caaggagtca 1740 aaagaagaaa cccctgaggt cacaaaagtg aatcacgtgg aaaagccacc caaagttgaa 1800 agcaaagaaa aggtaatggt gaaaaaagac aagccaataa aaacagagac caaaccttca 1860 gtgactgaaa aggaggttcc cagcaaagaa gagccatctc cagtgaaagc cgaggtggct 1920 gagaagcaag ccacagatgt caaacccaaa gctgccaagg agaagacggt gaaaaaggaa 1980 acaaaggtaa agcctgaaga caagaaagag gagaaagaaa agccaaagaa agaagtggct 2040 aaaaaggagg acaaaacacc tatcaagaag gaggaaaaac caaaaaagga agaggtgaaa 2100 aaagaagtca aaaaagagat caagaaagaa gagaaaaaag aacccaagaa agaggttaag 2160 aaagaaacac cgccaaagga agtcaagaag gaagttaaga aggaagagaa gaaggaagtg 2220 aaaaaggaag aaaaggaacc caaaaaagaa attaagaagc tccctaaaga cgcaaagaaa 2280 tcatctactc ctctgtctga agcaaaaaaa ccagctgctt taaaaccaaa agtacccaag 2340 aaggaagagt ctgtcaagaa agattctgtt gctgccggaa agccaaagga gaaggggaaa 2400 ataaaagtca ttaagaagga aggcaaggcc gcagaggctg tcgctgcagc tgtcggcact 2460 ggagccacca cagcagctgt catggcggca gctggaatag cagccattgg ccctgccaaa 2520 gaactcgaag ctgagaggtc ccttatgtca tctcctgagg atctaaccaa ggactttgaa 2580 gagttaaagg ctgaagaggt cgatgtaaca aaggacatca agcctcagct ggagctaatc 2640 gaagacgaag agaaactgaa ggaaactgag ccagtcgaag cctacgtcat ccagaaggag 2700 agagaagtca ccaaaggtcc tgccgagtcc cctgatgagg gaatcactac cactgaaggg 2760 gagggcgaat gtgaacagac acctgaggag ctggagcccg tcgagaagca gggagtagac 2820 gacattgaaa aatttgaaga tgaaggagcc ggttttgaag aatcttcaga gactggagac 2880 tatgaagaga aggcagaaac tgaggaggct gaggagccag aagaggatgg ggaggaacac 2940 gtatgtgtga gcgcctccaa gcacagcccc actgaggatg aggaaagtgc caaggcggag 3000 gctgatgcat acatcaggga gaagagggag tctgtggcca gtggggatga ccgagccgaa 3060 gaagacatgg atgaggccat tgagaaagga gaggctgaac aatctgaaga ggaggctgat 3120 gaggaggaca aagctgaaga tgccagagag gaggaatatg agccggaaaa aatggaagct 3180 gaagactatg tgatggctgt ggtcgacaag gctgcagagg ctggtggtgc cgaggagcag 3240 tatggattcc tcaccacacc aaccaagcaa ctaggagccc agtctcctgg ccgagaacct 3300 gcatcttcaa ttcatgatga gactttacct ggaggctcag agagcgaggc caccgcttct 3360 gatgaggaga atcgagaaga ccagcctgag gaattcactg ccacctctgg ctacactcag 3420 tctactattg agatatccag tgagcccacc cccatggatg agatgtctac ccctcgagac 3480 gtgatgagtg atgagaccaa caatgaagag acggagtccc cttctcagga attcgtaaat 3540 atcaccaaat atgaatcttc attgtattct caggaatact ctaaacctgc tgatgttaca 3600 ccgctcaacg gattttctga aggatcaaaa acagatgcca ctgatggcaa ggattacaat 3660 gcttcagcct ctaccatatc accaccctct tccatggagg aagacaaatt cagcagatct 3720 gctttacgtg atgcttactg ctctgaagtg aaagccagca ccactttgga catcaaagat 3780 agcatctcag ctgtttcaag tgaaaaggtc agcccatcga agagcccgtc cctgagtcca 3840 tctccaccat cacccttaga aaagaccccc ctgggtgaac gtagtgtgaa cttctctctg 3900 acgcccaatg agattaaagt ctctgcagag gcagaagtag ccccggtgtc tcctgaggtg 3960 acccaagaag tagttgaaga acatgtgct agtcctgagg acaagactct ggaagtggtg 4020 tcaccatctc agtccgtgac tggcagtgct ggtcacacac cttactatca atctcctact 4080 gacgagaaat ccagtcatct ccctacagaa gtcattgaaa aaccaccagc agttccagtg 4140 agttttgaat tcagtgatgc caaagatgag aatgaaaggg cttcagtaag ccccatggat 4200 gagcccgtgc ctgactcaga gtctcctatt gaaaaagttt tgtctccttt acgcagcccg 4260 cccctcattg gatccgagtc tgcttatgaa agttttctaa gtgctgatga caaggcttct 4320 ggcagaggtg ccgaaagtcc ttttgaagaa aagagtggaa aacaaggctc tccagaccaa 4380 gtaagtccag tttctgaaat gacttctact agtctttacc aagacaaaca ggaagggaaa 4440 agcacagact ttgcaccaat aaaagaagac tttggccaag aaaagaaaac tgatgatgtt 4500 gaagccatga gttctcaacc agcactggct ctggatgaaa ggaaattag agatgtttct 4560 cccacacaaa tagatgtcag tcagtttgga tcttttaaag aagacactaa gatgtccatt 4620 tctgaaggta ctgtctcaga caagtcagct actcctgttg atgagggcgt agcagaagac 4680 acgtactctc atatggaggg tgtggcctca gtgtccacag cctcagtggc tacgagctca 4740 tttccagagc caacaacaga tgatgtgtct ccatctctgc atgctgaggt tggctcccca 4800 cattccacag aagtagatga ctccctttca gtgtctgttg tgcaaacacc taccacattc 4860 caggaaacag aaatgtctcc atctaaagaa gaatgcccaa gaccgatgtc aatttctcca 4920 ccagatttct cccctaaaac tgcaaagtcc aggacacccg ttcaagatca cagatctgaa 4980 cagtcctcaa tgtctattga atttggccaa gaatctcctg agcaatccct tgctatggac 5040 ttcagtcgac agtctccaga tcaccctaca gtgggtgcag gcgtgcttca catcactgaa 5100 aatgggccaa ctgaagtgga ctacagtcct tctgacatgc aggactccag tttatcacat 5160 aagataccac ctatggagga gccgtcctac acccaagata atgatctttc tgagctcatc 5220 tcagtatctc aggtagaggc ctccccgtcc acctcttctg ctcatacccc ttctcagatc 5280 gcttctcctc tccaagaaga tactctatcc gatgttgctc ctcccagaga tatgtcctta 5340 tatgcctcac tcacctctga aaaagtgcaa agtctggaag gagagaagct ctctccaaaa 5400 tctgatatct ctccactcac cccacgagag tcctctcctt tatattcacc tactttttca 5460 gattctacct ctgcagtcaa agagaaaaca gcaacttgcc acagttcctc ttctccacca 5520 atagatgcag catccgcaga gccctatggc ttccgtgcct cagtgttatt cgatacaatg 5580 caacaccatc tagccttgaa tagagatttg tccacacctg gcctggagaa ggacagtgga 5640 gggaagacac ctggtgactt tagctatgcc tatcaaaagc ctgaggaaac aaccaggtcc 5700 ccagatgaag aagattatga ctatgagtct tatgagaaga ccacccggac ctcagatgtg 5760 ggtggctatt actatgagaa gatagagaga accacaaaat ctccaagtga cagtggctac 5820 tcctatgaga ccattgggaa aactaccaag acccctgaag atggtgacta ttcctatgaa 5880 attattgaga agaccacacg gacccctgaa gagggtgggt actcatatga cataagtgaa 5940 aagaccacca gcccccccga agtgagtggt tacagctatg aaaagactga gaggtctaga 6000 aggcttctgg atgacatcag caatggctat gatgactctg aggatggtgg ccacacactt 6060 ggggacccca gctactctta tgaaaccact gagaaaatta ccagtttccc tgagtctgaa 6120 ggttattcct atgagacatc tacaaagaca acacgaaccc ctgatacttc cacatactgt 6180 tacgagactg cagagaaaat cactagaacc cctcaggcat ccacatattc ctacgagact 6240 tcagacctat gctacactgc agaaaagaag tccccctcag aagcccgtca ggatgtcgat 6300 ttatgcctcg tgtcctcttg tgaatacaag caccccaaga cagagctttc accctctttc 6360 attaatccca atcctcttga gtggtttgcc agtgaagaac ccactgaaga atctgaaaag 6420 cccctcactc aatcaggggg agccccaccg cctccaggag gaaagcaaca gggccgacag 6480 tgtgatgaaa cccctcccac ctcagtcagc gagtcagccc catcccagac cgactctgat 6540 gttccccccgg agactgaaga gtgcccctcc atcacggccg atgccaatat cgactctgaa 6600 gacgagtcgg aaaccatccc cacagacaaa actgtcacgt acaaacacat ggacccacct 6660 ccagctcccg tgcaagaccg cagcccttcg ccacgccacc ctgatgtgtc catggtggac 6720 ccagaggcct tggccattga gcagaacctg ggcaaagctc taaagaaaga tctgaaagag 6780 aagaccaaaa ccaaaaagcc aggtacaaag accaagtcat cttcacctgt caaaaagagt 6840 gatgggaagt ctaagccctt ggcagcttca ccaaaaccag cgggcttgaa agaatcctcg 6900 gataaagtgt ccagggtggc ttctcctaag aagaaagaat ctgtggaaaa ggcagcaaaa 6960 cccaccacca ctcctgaggt caaagctgca cgtggggaag agaaagacaa ggagaccaag 7020 aatgctgcca atgcctctgc atccaagtcg gccaagaccg ccactgcagg accaggaact 7080 accaagacga ccaagtcatc tgctgtgccc ccaggcctcc ctgtgtattt ggacctgtgc 7140 tacattccta accacagcaa tagtaagaat gttgatgtgg aatttttcaa gagagtgcgg 7200 tcttcctact acgtggtgag tgggaatgac cctgctgctg aggagcccag ccgggctgtc 7260 ctggacgctt tgttggaagg aaaggctcag tggggcagca acatgcaggt gacactgatc 7320 ccaactcatg actcagaagt gatgagggaa tggtaccagg agacccatga gaaacagcaa 7380 gatctcaaca tcatggtttt agcaagcagc agcacagtgg ttatgcaaga tgaatccttc 7440 cctgcatgca agattgaact gtaaaaacca aggccagcca caccacagga tctgaacttt 7500 gtttccagaa attcttcaat ttgaaatcac cttttctaaa aagtcaattc atctagttaa 7560 gtcgctgaac aattacctgc caaatgctat actgtgtcat ggtgatgcaa gtcactaaat 7620 ttctcagttt ttgctgattg ctaagggaaa taacagtatt tccacaatag ggttcaaatt 7680 cctgcaaaat tacctacccc agttcatctc tgctgaacat ttggaaacca tgcactagcc 7740 aacccaactg acttctgcta ggtagaggca tttgtcttag agagagagag agcgcgggag 7800 agagtgagag agagtgagag cacaaagata acgcaggaga gagagagaga aagaatgaga 7860 aagaaaagga atgcaagaga aggagatgta atgacagaga gttctggtga gatacccaga 7920 gagaaaaaga gagagcaggg tggggtaagg aggagaaaat aaaccaacaa ttaggtctgc 7980 attttctcag gcagtaggca ttctttagtc tacataggca aagttttcca tttttgtcag 8040 tctgagtcat caaaaagagt cttaattttc taaaacaagt tggctagaag aaagtaaaaa 8100 gaacaacact tgttatgagg gcatgtgata ttttcacatc ttaattaagc tccttcagtt 8160 tgaaggctgc acactgacat aatgtagtga gtgtagactg gccatgcaag tggtttgggc 8220 cccattcaga actctcagac tctaaacaca caagtagatt gatctaaggc atgctcccag 8280 catttgtcca cccacttagt ccactctgag tcgattaacc tgcatgcagc aacacccaag 8340 tccaccccaa ttaactgaag caaataccaa agcagttggg agtacatatg gtagacaatt 8400 tgccttagga agtgacttga atgtacaaag atacttgatg cacttatttt ttaatgtgag 8460 acagcaagtt tataaaacat ccatatagga ttatagatac ttaaaggaac acgtgggtga 8520 gcgtgtgtgg gggtactaga agctgatctg attggtccaa cagtttgatg ctgagtcatg 8580 cgtgttgaat cccacttcag tgcacctgtg gcctctcagt caaacaagtt gtgcctttca 8640 cagcttcttt actactgcaa gttcaagact gaaatggctt ctatgatcag aactgggaaa 8700 acagtgaatc ttatggtgga agaggttctc agcaagtgta cagtatttac cttcctttgt 8760 cttacattgg ctttttaaat tttccattaa tttcaacata attatgggaa caagtgtaca 8820 gaagaatttt ttttttaaga tatgtgagaa cttttcatag atgaactttt taacaaatgt 8880 tttcatttac aggaaattgc aaagaaaatt ctcaagtgat agtctttttt tttaagtgtt 8940 tcgtaagaca aaaattgaat aatgtttttt gaagttctgg caagattgaa gtctgatatt 9000 gcagtaatga tatttattaa aaacccataa ctaccaggaa taatgatacc tccccacccct 9060 tgattcccat aacataaaag tgctacttga gagtggggga gaatggcatg gtaggctact 9120 tttcagggcc ttgacaagta catcacccag tggtatccta catacttctt tcaagatctt 9180 caaccatgag gtaaaagagc caagttcaaa gaaccctagc acaaatttgc tttgggattt 9240 tcttttctgg aaaaaaaaaa taaaagaaat agtacattga aaacaaatga attctcaact 9300 cctacggttc atgtagagtt tagagaaaat ttccatcatt gtcatcattg aactgtgaac 9360 ctgggaagcc agatcatgat taacactgac atcaagtttc aagttgcaga tcaatgcacc 9420 cagtgttcag atgaggcaaa cttctccgtg acaactgtgc tgtgctctgt cacattacat 9480 ttcctgcaga ctctaagatc tacggagtag agaacaatga cctcatttta ttttctatgt 9540 tagttattta tttcaaaatt aacattttag ttgatttttg tctgataagt ctatgttttg 9600 cactgctaac tatgatgagg gtttaaaaaa atgcttcttc agggtccttt cactgaggac 9660 ctatgcagtc tacttaatgc tgtgaattac atttttcaaa tgtttaattt tttaaagaaa 9720 attaatattc tatttttgtt aggcttctct agaaatgcag cttttattta ttaccccatt 9780 tctttcaagt ccttggaaaa taacatatta agggtacaag aaattaacac atgatggaaa 9840 agtcattgtg acgccaatga atttcattga gtataaactc atctacttca aatttatttt 9900 ataacacaac ctaagatact caagataatt atttaatggt tagctcttaa gttgaattgg 9960 tctacataat gcgtgggaag aaaaccagat ttttagcctt cttgccaaat ccagacctct 10020 ggttgatttt tctttgacag aagatgcaag ttattttcca atttcacaat taaatgtatt 10080 taacctgaac attattttgc tttaaaaact ataaacattg taggagaatt atagccagtc 10140 ttcagttata accactccac cctcctcact ttctctctct ctctctcttt tttttttttt 10200 ttttttttgc tatgggattt aatgggaaaa atatgtaaaa actgtcacta gtcagctggc 10260 tctttttcct atgaaatcta tcagtacctt tctccatccg ttgttctcaa tatgaccaca 10320 gagcctgagt ataccaagaa aaccaatatt cgcattacag gttgctcctg tccttccaga 10380 cacctttcct gcctgtgtga ctaacctaat tttgctagtt ccataaatac acgattagtt 10440 tagtaacagc catcacaatg taccatgtac attcatggtg agagctaaag atcgacacag 10500 acttctagga gctttgttca tactgattac ttaatccaat tgtatagatt gaatatttga 10560 gtggaaggaa tttacactct gtttaaatga tgggattcta tcgagatagc actcatgatc 10620 atgacctttt tggtagtatt cttaaacaaa attctacaga gactaaatgt tagcgatgat 10680 cctccatttt caattttaac caattctgtc ccctttctca aaaccctgag ccctgtgcat 10740 gctttctcag tcttgtggtg ggactggata caatgactaa cttcccctcc tcccctcttt 10800 aaacaccatt ttccatggag ttcaaaaaaa ttttttttct taacgttaca tatcatagtg 10860 aatggtttcc ccagtgtata tgaatgtttt aagtgtctcc aatagcttat gcagtctagg 10920 agctttccaa tactcattta attaagattt aatcatttgc taatggaaat cttaccacct 10980 ttcattttcc ctctgttacc aaatttcagc tcttaggagc tgctctacaa ttctgaattt 11040 gcttttcttg cctctcttta gtcacctgtc acaggaggtt cctgctcagt aatgatattg 11100 tgagttagga taataacttt ttttttttgt gcttcagatt tagaagaaaa gatcctgttt 11160 ccatttgaaa ggaactgtaa gcttttatct tttaaccaac tgaacaatac accaaaagca 11220 gcctagggat gagcatttct ttgaaagcaa ttaggttatt cacctggtat taaaactatt 11280 tactgttaaa aaatctgtga cttcatgaag ttgattttta aaggcagcat caaaaactga 11340 aaaggaaggg aaaaaatagg cagcttctct gcacttgttt ggagctcccc aaaacaggag 11400 ccatggagaa gtggcatcaa gaccgggctg ccctttcgag aacaccctgt ggcagttcag 11460 agacacgctt ttcctacact gcatgcagcc cctctttcca gcactggaaa gaagtggtct 11520 tgagcccagc tgagaagcac ttcacactcc tctctcttgt tctgaatggt gtttgtgtca 11580 gtctgcagct gtgtatggta ttatgtctta taatcctgca tcacttctat cctatccagt 11640 catatctaat gtagaaaatt agtttccagt gaaagtaata tgtagtgctt ttatgatatt 11700 tgtgtgcaat atcccctctt ccattgagga tatttgatgt aaaggaaaaa aaaaaactca 11760 gttccacaat aaaatacaaa agtggcaaaa 11790

Claims (10)

A composition for predicting treatment effect or prognosis diagnosis according to the age of a prostate cancer patient, comprising an agent capable of detecting a mutation in a gene encoding ASPH, ITPR1 and SHISAL1.
The method of claim 1,
The composition for diagnosis is ABCC10, ACTL6A, ADARB2, ANKRD30B, ARHGAP10, ATRNL1, C11orf24, CAMKK1, CD14, CELF3, CLCN2, CLIP4, CRIM1, CXorf56, CYP4F11, DYTN, FIGNL1, FOXE1, GFSCN2, FOXE1, GFSCN2. INTU, POGLUT2, KDM4B, KIAA0355, KIRREL2, KLKB1, KRT37, LETMD1, MAML2, MAP1B and METTL9 of the prostate cancer patient further comprising an agent capable of detecting a mutation in a gene encoding at least one selected from the group consisting of A composition for predicting treatment effect according to age or diagnosing prognosis.
The method of claim 1,
The mutation in the gene encoding ASPH is a missense mutation that is at least one of A382V and V676M in the amino acid sequence of SEQ ID NO: 1;
The mutation of the gene encoding ITPR1 is at least one missense mutation selected from the group consisting of C2395Y, G2146R and A597T in the amino acid sequence of SEQ ID NO: 2, or A1894Lfs*8 frame shift deletion (frame shift delete, FS del ) is a mutation;
The mutation of the gene encoding SHISAL1 is a missense mutation that is one of R29W and L117V in the amino acid sequence of SEQ ID NO: 3; In, a composition for predicting treatment effect or prognosis diagnosis according to the age of a prostate cancer patient.
3. The method of claim 2,
The mutation of the gene encoding ABCC10 is a missense mutation of at least one of R570Q and E593Q, or a nonsense mutation of R545* in the amino acid sequence of SEQ ID NO: 4;
The mutation in the gene encoding ACTL6A is a missense mutation that is at least one of R76H and G26D in the amino acid sequence of SEQ ID NO: 5;
the mutation of the gene encoding ADARB2 is at least one missense mutation selected from the group consisting of A703V, R520H and L480P in the amino acid sequence of SEQ ID NO: 6;
the mutation of the gene encoding ANKRD30B is at least one missense mutation selected from the group consisting of D570Y, S574F and I1058T in the amino acid sequence of SEQ ID NO: 7;
The mutation in the gene encoding ARHGAP10 is a missense mutation of E195D or a splice mutation of X464_splice in the amino acid sequence of SEQ ID NO: 8;
The mutation in the gene encoding ATRNL1 is a missense mutation that is at least one of E905K and H313Y in the amino acid sequence of SEQ ID NO: 9;
The mutation in the gene encoding C11orf24 is a missense mutation that is A395V in the amino acid sequence of SEQ ID NO: 10;
The mutation of the gene encoding CAMKK1 is a missense mutation that is at least one of A201V and V238I in the amino acid sequence of SEQ ID NO: 11;
The mutation of the gene encoding CD14 is a missense mutation that is at least one of R33C and A375T in the amino acid sequence of SEQ ID NO: 12;
The mutation of the gene encoding CELF3 is a missense mutation that is A245T or a mutation that is a frame shift delete (FS del) that is S260Afs*167 in the amino acid sequence of SEQ ID NO: 13;
The mutation of the gene encoding CLCN2 is a missense mutation that is at least one of R646Q and G199R in the amino acid sequence of SEQ ID NO: 14;
the mutation of the gene encoding CLIP4 is a missense mutation that is at least one of S55L and R673H in the amino acid sequence of SEQ ID NO: 15;
the mutation in the gene encoding CRIM1 is a missense mutation that is at least one of D352G and S313C in the amino acid sequence of SEQ ID NO: 16;
the mutation of the gene encoding CXorf56 is a missense mutation that is at least one of E150K and T115M in the amino acid sequence of SEQ ID NO: 17;
the mutation of the gene encoding CYP4F11 is a missense mutation that is at least one of R515W and T152M in the amino acid sequence of SEQ ID NO: 18;
The mutation of the gene encoding DYTN is a missense mutation of W209R or a nonsense mutation of Q470* in the amino acid sequence of SEQ ID NO: 19;
the mutation in the gene encoding FIGNL1 is a frame shift deletion mutation that is at least one of K326Sfs*3 and E64Rfs*16 in the amino acid sequence of SEQ ID NO: 20;
The mutation of the gene encoding FOXE1 is an in-frame delete (IF del) mutation that is A178_A179del in the amino acid sequence of SEQ ID NO: 21;
The mutation in the gene encoding FSCN2 is a missense mutation that is at least one of V261L and T244M in the amino acid sequence of SEQ ID NO: 22;
The mutation in the gene encoding FTMT is a missense mutation that is at least one of R23C and R20H in the amino acid sequence of SEQ ID NO: 23;
The mutation in the gene encoding PI4KB is a missense mutation that is at least one of C406F and M223I in the amino acid sequence of SEQ ID NO: 24;
The mutation of the gene encoding GLYCTK is a missense mutation that is at least one of A142V and T466S in the amino acid sequence of SEQ ID NO: 25;
the mutation of the gene encoding GLYR1 is at least one missense mutation selected from the group consisting of T205A, R171W and P184L in the amino acid sequence of SEQ ID NO: 26;
The mutation of the gene encoding the INTU is a frame shift insert (FS ins) mutation of D229Vfs*7 or a missense mutation of R705C in the amino acid sequence of SEQ ID NO: 27;
The mutation of the gene encoding POGLUT2 is a missense mutation that is one of H191Q and H251N in the amino acid sequence of SEQ ID NO: 28;
The mutation of the gene encoding KDM4B is, in the amino acid sequence of SEQ ID NO: 29, a missense mutation of at least one of I256V and V66M, a frame shift insertion mutation of N103Kfs*14, or a splice mutation of D145=;
The mutation in the gene encoding KIAA0355 is at least one missense mutation selected from the group consisting of A311T, R16H and A280V in the amino acid sequence of SEQ ID NO: 30, or a nonsense mutation that is Q345*;
The mutation of the gene encoding KIRREL2 is a missense mutation that is at least one of P22L and L61Q in the amino acid sequence of SEQ ID NO: 31;
the mutation of the gene encoding KLKB1 is a missense mutation that is at least one of R390H and D114Y in the amino acid sequence of SEQ ID NO: 32;
The mutation in the gene encoding KRT37 is a missense mutation that is at least one of A217T and N287D in the amino acid sequence of SEQ ID NO: 33;
The mutation in the gene encoding LETMD1 is a missense mutation that is at least one of V84A and Q301H in the amino acid sequence of SEQ ID NO: 34;
The mutation of the gene encoding MAML2 is a missense mutation that is at least one of P1120S and P1022S in the amino acid sequence of SEQ ID NO: 35;
the mutation of the gene encoding MAP1B is a missense mutation that is at least one of R1275H and G1185R in the amino acid sequence of SEQ ID NO: 36;
The mutation of the gene encoding METTL9 is a missense mutation that is at least one of V307I and P165L in the amino acid sequence of SEQ ID NO: 37; In, A composition for predicting treatment effect or prognosis diagnosis according to the age of a prostate cancer patient.
3. The method according to claim 1 or 2,
The agent is a primer set or probe for the mutation of the gene, or an antibody to the protein expressed by the mutation of the gene, The composition for predicting treatment effect or prognosis diagnosis according to the age of a prostate cancer patient.
A kit for predicting treatment effect or prognosis diagnosis according to the age of a prostate cancer patient, comprising the composition of claim 1 or 2.
preparing sample DNA from a sample of a prostate cancer patient;
amplifying the sample DNA using the kit of claim 6; and
A method of providing information necessary for prognostic diagnosis of prostate cancer according to the age of a prostate cancer patient, comprising: confirming the presence or absence of an age-specific marker from the amplification result.
8. The method of claim 7,
The method is a method of predicting the overall survival rate or disease-free survival rate of prostate cancer patients.
9. The method of claim 8,
When a mutation is identified in the genes encoding ASPH, ITPR1 and SHISAL1, and if the patient is a patient with prostate cancer, the survival rate of the prostate cancer patient is lower than that of a person in which the mutation is not confirmed in the gene, or the prostate cancer of the prostate cancer patient The method further comprising; determining that the recurrence rate of the gene is higher than the recurrence rate of prostate cancer of a person whose mutation has not been confirmed.
10. The method of claim 9,
ABCC10, ACTL6A, ADARB2, ANKRD30B, ARHGAP10, ATRNL1, C11orf24, CAMKK1, CD14, CELF3, CLCN2, CLIP4, CRIM1, CXorf56, CYP4F11, DYTN, FIGNL1, FOXE1, FSCN2, FTTK , GPO RPIUT, INTUMT, PORCN2, FT2 When a mutation is identified in a gene encoding at least one selected from the group consisting of KDM4B, KIAA0355, KIRREL2, KLKB1, KRT37, LETMD1, MAML2, MAP1B and METTL9, the survival rate of prostate cancer patients is determined by the absence of a mutation in the gene. Determining that the survival rate of a person is lower than the survival rate of a person, or that the recurrence rate of prostate cancer in the prostate cancer patient is higher than the recurrence rate of prostate cancer in a person whose mutation in the gene is not confirmed.

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