ES2920288T3 - Procedimientos para la detección de melanoma - Google Patents
Procedimientos para la detección de melanoma Download PDFInfo
- Publication number
- ES2920288T3 ES2920288T3 ES18731615T ES18731615T ES2920288T3 ES 2920288 T3 ES2920288 T3 ES 2920288T3 ES 18731615 T ES18731615 T ES 18731615T ES 18731615 T ES18731615 T ES 18731615T ES 2920288 T3 ES2920288 T3 ES 2920288T3
- Authority
- ES
- Spain
- Prior art keywords
- expression level
- hla
- cflar
- melanoma
- subject
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 201000001441 melanoma Diseases 0.000 title abstract description 105
- 238000000034 method Methods 0.000 title abstract description 34
- 238000012216 screening Methods 0.000 title description 3
- 238000002560 therapeutic procedure Methods 0.000 abstract description 23
- 238000001356 surgical procedure Methods 0.000 abstract description 15
- 238000002271 resection Methods 0.000 abstract description 11
- 230000000750 progressive effect Effects 0.000 abstract description 9
- 230000004044 response Effects 0.000 abstract description 8
- 230000014509 gene expression Effects 0.000 description 176
- -1 CFLAR-AS1 Proteins 0.000 description 73
- 239000000090 biomarker Substances 0.000 description 67
- 239000000523 sample Substances 0.000 description 49
- JPKJQBJPBRLVTM-OSLIGDBKSA-N (2s)-2-amino-n-[(2s,3r)-3-hydroxy-1-[[(2s)-1-[[(2s)-1-[[(2s)-1-[[(2r)-1-(1h-indol-3-yl)-3-oxopropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-1-oxobutan-2-yl]-6-iminohexanamide Chemical compound C([C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)CCCC=N)[C@H](O)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@H](CC=1C2=CC=CC=C2NC=1)C=O)C1=CC=CC=C1 JPKJQBJPBRLVTM-OSLIGDBKSA-N 0.000 description 38
- 102100038263 ATP-dependent RNA helicase DDX55 Human genes 0.000 description 38
- 102100031277 Calcineurin B homologous protein 1 Human genes 0.000 description 38
- 241000839426 Chlamydia virus Chp1 Species 0.000 description 38
- 102100024108 Dystrophin Human genes 0.000 description 38
- 102000052930 Fanconi Anemia Complementation Group L protein Human genes 0.000 description 38
- 108700026162 Fanconi Anemia Complementation Group L protein Proteins 0.000 description 38
- 102100031547 HLA class II histocompatibility antigen, DO alpha chain Human genes 0.000 description 38
- 102100040505 HLA class II histocompatibility antigen, DR alpha chain Human genes 0.000 description 38
- 108010067802 HLA-DR alpha-Chains Proteins 0.000 description 38
- 102100022107 Holliday junction recognition protein Human genes 0.000 description 38
- 101000883820 Homo sapiens ATP-dependent RNA helicase DDX55 Proteins 0.000 description 38
- 101000777252 Homo sapiens Calcineurin B homologous protein 1 Proteins 0.000 description 38
- 101000943802 Homo sapiens Cysteine and histidine-rich domain-containing protein 1 Proteins 0.000 description 38
- 101001053946 Homo sapiens Dystrophin Proteins 0.000 description 38
- 101001107084 Homo sapiens E3 ubiquitin-protein ligase RNF5 Proteins 0.000 description 38
- 101100119754 Homo sapiens FANCL gene Proteins 0.000 description 38
- 101000866278 Homo sapiens HLA class II histocompatibility antigen, DO alpha chain Proteins 0.000 description 38
- 101001045907 Homo sapiens Holliday junction recognition protein Proteins 0.000 description 38
- 101000852980 Homo sapiens Interleukin-23 subunit alpha Proteins 0.000 description 38
- 101000877521 Homo sapiens Mitochondrial enolase superfamily member 1 Proteins 0.000 description 38
- 101000613207 Homo sapiens Pre-B-cell leukemia transcription factor-interacting protein 1 Proteins 0.000 description 38
- 101000880116 Homo sapiens SERTA domain-containing protein 2 Proteins 0.000 description 38
- 101000828739 Homo sapiens SPATS2-like protein Proteins 0.000 description 38
- 101000713936 Homo sapiens Tudor domain-containing protein 7 Proteins 0.000 description 38
- 108010050332 IQ motif containing GTPase activating protein 1 Proteins 0.000 description 38
- 102100036705 Interleukin-23 subunit alpha Human genes 0.000 description 38
- 102100035387 Mitochondrial enolase superfamily member 1 Human genes 0.000 description 38
- 102100040882 Pre-B-cell leukemia transcription factor-interacting protein 1 Human genes 0.000 description 38
- 102000056817 RNF5 Human genes 0.000 description 38
- 102100034419 Ras GTPase-activating-like protein IQGAP1 Human genes 0.000 description 38
- 102100037351 SERTA domain-containing protein 2 Human genes 0.000 description 38
- 108091006912 SLC35G5 Proteins 0.000 description 38
- 102100023521 SPATS2-like protein Human genes 0.000 description 38
- 101001053942 Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) Diphosphomevalonate decarboxylase Proteins 0.000 description 38
- 102100032019 Solute carrier family 35 member G5 Human genes 0.000 description 38
- 102100036455 Tudor domain-containing protein 7 Human genes 0.000 description 38
- 102100027766 Atlastin-1 Human genes 0.000 description 37
- 102100022845 DnaJ homolog subfamily C member 9 Human genes 0.000 description 37
- 101000936983 Homo sapiens Atlastin-1 Proteins 0.000 description 37
- 101000903036 Homo sapiens DnaJ homolog subfamily C member 9 Proteins 0.000 description 37
- 101000940146 Homo sapiens Transcription factor YY2 Proteins 0.000 description 37
- 102100031148 Transcription factor YY2 Human genes 0.000 description 37
- 238000012360 testing method Methods 0.000 description 37
- 102100025752 CASP8 and FADD-like apoptosis regulator Human genes 0.000 description 35
- 101000914211 Homo sapiens CASP8 and FADD-like apoptosis regulator Proteins 0.000 description 35
- 101000606067 Homo sapiens Tyrosine-protein kinase TXK Proteins 0.000 description 34
- 102100039079 Tyrosine-protein kinase TXK Human genes 0.000 description 34
- 108090000623 proteins and genes Proteins 0.000 description 30
- 210000004369 blood Anatomy 0.000 description 24
- 239000008280 blood Substances 0.000 description 24
- 108091032973 (ribonucleotides)n+m Proteins 0.000 description 20
- 239000003795 chemical substances by application Substances 0.000 description 19
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 19
- 201000010099 disease Diseases 0.000 description 17
- 210000001519 tissue Anatomy 0.000 description 17
- 239000002299 complementary DNA Substances 0.000 description 16
- 238000004422 calculation algorithm Methods 0.000 description 15
- 238000009169 immunotherapy Methods 0.000 description 15
- 102000004169 proteins and genes Human genes 0.000 description 15
- 206010028980 Neoplasm Diseases 0.000 description 14
- 230000003247 decreasing effect Effects 0.000 description 12
- 238000003556 assay Methods 0.000 description 11
- 210000004027 cell Anatomy 0.000 description 11
- 238000002626 targeted therapy Methods 0.000 description 11
- 108700039887 Essential Genes Proteins 0.000 description 10
- 101000762938 Homo sapiens TOX high mobility group box family member 4 Proteins 0.000 description 10
- 101000653679 Homo sapiens Translationally-controlled tumor protein Proteins 0.000 description 10
- ZBZXYUYUUDZCNB-UHFFFAOYSA-N N-cyclohexa-1,3-dien-1-yl-N-phenyl-4-[4-(N-[4-[4-(N-[4-[4-(N-phenylanilino)phenyl]phenyl]anilino)phenyl]phenyl]anilino)phenyl]aniline Chemical compound C1=CCCC(N(C=2C=CC=CC=2)C=2C=CC(=CC=2)C=2C=CC(=CC=2)N(C=2C=CC=CC=2)C=2C=CC(=CC=2)C=2C=CC(=CC=2)N(C=2C=CC=CC=2)C=2C=CC(=CC=2)C=2C=CC(=CC=2)N(C=2C=CC=CC=2)C=2C=CC=CC=2)=C1 ZBZXYUYUUDZCNB-UHFFFAOYSA-N 0.000 description 10
- 102100026749 TOX high mobility group box family member 4 Human genes 0.000 description 10
- 102100029887 Translationally-controlled tumor protein Human genes 0.000 description 10
- 238000011282 treatment Methods 0.000 description 9
- 108020004414 DNA Proteins 0.000 description 8
- 238000001514 detection method Methods 0.000 description 8
- 238000003745 diagnosis Methods 0.000 description 8
- 150000007523 nucleic acids Chemical class 0.000 description 8
- 230000035945 sensitivity Effects 0.000 description 8
- 238000002651 drug therapy Methods 0.000 description 7
- 230000035772 mutation Effects 0.000 description 7
- 230000001613 neoplastic effect Effects 0.000 description 7
- 125000003729 nucleotide group Chemical group 0.000 description 7
- 239000012472 biological sample Substances 0.000 description 6
- 230000008859 change Effects 0.000 description 6
- 238000009396 hybridization Methods 0.000 description 6
- 239000002773 nucleotide Substances 0.000 description 6
- 108091033319 polynucleotide Proteins 0.000 description 6
- 102000040430 polynucleotide Human genes 0.000 description 6
- 239000002157 polynucleotide Substances 0.000 description 6
- 229940125431 BRAF inhibitor Drugs 0.000 description 5
- 238000002512 chemotherapy Methods 0.000 description 5
- 108020004707 nucleic acids Proteins 0.000 description 5
- 102000039446 nucleic acids Human genes 0.000 description 5
- 210000002381 plasma Anatomy 0.000 description 5
- 210000002966 serum Anatomy 0.000 description 5
- 208000024891 symptom Diseases 0.000 description 5
- GPXBXXGIAQBQNI-UHFFFAOYSA-N vemurafenib Chemical compound CCCS(=O)(=O)NC1=CC=C(F)C(C(=O)C=2C3=CC(=CN=C3NC=2)C=2C=CC(Cl)=CC=2)=C1F GPXBXXGIAQBQNI-UHFFFAOYSA-N 0.000 description 5
- 238000012935 Averaging Methods 0.000 description 4
- 238000011156 evaluation Methods 0.000 description 4
- 229960003301 nivolumab Drugs 0.000 description 4
- 238000004393 prognosis Methods 0.000 description 4
- 101000984753 Homo sapiens Serine/threonine-protein kinase B-raf Proteins 0.000 description 3
- 102000003855 L-lactate dehydrogenase Human genes 0.000 description 3
- 108700023483 L-lactate dehydrogenases Proteins 0.000 description 3
- 108020004711 Nucleic Acid Probes Proteins 0.000 description 3
- 108091093037 Peptide nucleic acid Proteins 0.000 description 3
- 102100027103 Serine/threonine-protein kinase B-raf Human genes 0.000 description 3
- BFSMGDJOXZAERB-UHFFFAOYSA-N dabrafenib Chemical compound S1C(C(C)(C)C)=NC(C=2C(=C(NS(=O)(=O)C=3C(=CC=CC=3F)F)C=CC=2)F)=C1C1=CC=NC(N)=N1 BFSMGDJOXZAERB-UHFFFAOYSA-N 0.000 description 3
- 230000007423 decrease Effects 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 238000003384 imaging method Methods 0.000 description 3
- 229960005386 ipilimumab Drugs 0.000 description 3
- 239000003550 marker Substances 0.000 description 3
- 238000005259 measurement Methods 0.000 description 3
- 239000002853 nucleic acid probe Substances 0.000 description 3
- 230000002829 reductive effect Effects 0.000 description 3
- 230000001225 therapeutic effect Effects 0.000 description 3
- LIRYPHYGHXZJBZ-UHFFFAOYSA-N trametinib Chemical compound CC(=O)NC1=CC=CC(N2C(N(C3CC3)C(=O)C3=C(NC=4C(=CC(I)=CC=4)F)N(C)C(=O)C(C)=C32)=O)=C1 LIRYPHYGHXZJBZ-UHFFFAOYSA-N 0.000 description 3
- 229960003862 vemurafenib Drugs 0.000 description 3
- QVVIXDOSSOQBLP-RKQHYHRCSA-N 1-[(4-methylphenyl)methylimino]-3-[(2r,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]thiourea Chemical compound C1=CC(C)=CC=C1CN=NC(=S)N[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 QVVIXDOSSOQBLP-RKQHYHRCSA-N 0.000 description 2
- 102100027831 14-3-3 protein theta Human genes 0.000 description 2
- 102100040685 14-3-3 protein zeta/delta Human genes 0.000 description 2
- AQQSXKSWTNWXKR-UHFFFAOYSA-N 2-(2-phenylphenanthro[9,10-d]imidazol-3-yl)acetic acid Chemical compound C1(=CC=CC=C1)C1=NC2=C(N1CC(=O)O)C1=CC=CC=C1C=1C=CC=CC=12 AQQSXKSWTNWXKR-UHFFFAOYSA-N 0.000 description 2
- 102100029511 26S proteasome regulatory subunit 6B Human genes 0.000 description 2
- 102100028104 39S ribosomal protein L19, mitochondrial Human genes 0.000 description 2
- 102100040881 60S acidic ribosomal protein P0 Human genes 0.000 description 2
- 102100022289 60S ribosomal protein L13a Human genes 0.000 description 2
- 102100026611 Alpha-1,2-mannosyltransferase ALG9 Human genes 0.000 description 2
- 102100027314 Beta-2-microglobulin Human genes 0.000 description 2
- 102100026031 Beta-glucuronidase Human genes 0.000 description 2
- 208000005443 Circulating Neoplastic Cells Diseases 0.000 description 2
- 101100421140 Danio rerio selenon gene Proteins 0.000 description 2
- ZHNUHDYFZUAESO-UHFFFAOYSA-N Formamide Chemical compound NC=O ZHNUHDYFZUAESO-UHFFFAOYSA-N 0.000 description 2
- 101000723543 Homo sapiens 14-3-3 protein theta Proteins 0.000 description 2
- 101000964898 Homo sapiens 14-3-3 protein zeta/delta Proteins 0.000 description 2
- 101001125524 Homo sapiens 26S proteasome regulatory subunit 6B Proteins 0.000 description 2
- 101001079803 Homo sapiens 39S ribosomal protein L19, mitochondrial Proteins 0.000 description 2
- 101000673456 Homo sapiens 60S acidic ribosomal protein P0 Proteins 0.000 description 2
- 101000681240 Homo sapiens 60S ribosomal protein L13a Proteins 0.000 description 2
- 101000756632 Homo sapiens Actin, cytoplasmic 1 Proteins 0.000 description 2
- 101000717828 Homo sapiens Alpha-1,2-mannosyltransferase ALG9 Proteins 0.000 description 2
- 101000937544 Homo sapiens Beta-2-microglobulin Proteins 0.000 description 2
- 101000933465 Homo sapiens Beta-glucuronidase Proteins 0.000 description 2
- 101000896557 Homo sapiens Eukaryotic translation initiation factor 3 subunit B Proteins 0.000 description 2
- 101000988834 Homo sapiens Hypoxanthine-guanine phosphoribosyltransferase Proteins 0.000 description 2
- 101000969546 Homo sapiens Mortality factor 4-like protein 1 Proteins 0.000 description 2
- 101001111252 Homo sapiens NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial Proteins 0.000 description 2
- 101001109052 Homo sapiens NADH-ubiquinone oxidoreductase chain 4 Proteins 0.000 description 2
- 101001067833 Homo sapiens Peptidyl-prolyl cis-trans isomerase A Proteins 0.000 description 2
- 101000579123 Homo sapiens Phosphoglycerate kinase 1 Proteins 0.000 description 2
- 101001068630 Homo sapiens Protein PRRC2B Proteins 0.000 description 2
- 101000863956 Homo sapiens Protein dopey-2 Proteins 0.000 description 2
- 101000616974 Homo sapiens Pumilio homolog 1 Proteins 0.000 description 2
- 101000707546 Homo sapiens Splicing factor 3A subunit 1 Proteins 0.000 description 2
- 101000685323 Homo sapiens Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial Proteins 0.000 description 2
- 101000835093 Homo sapiens Transferrin receptor protein 1 Proteins 0.000 description 2
- 102100029098 Hypoxanthine-guanine phosphoribosyltransferase Human genes 0.000 description 2
- 102000000588 Interleukin-2 Human genes 0.000 description 2
- 108010002350 Interleukin-2 Proteins 0.000 description 2
- 206010024218 Lentigo maligna Diseases 0.000 description 2
- 241000124008 Mammalia Species 0.000 description 2
- 102100021395 Mortality factor 4-like protein 1 Human genes 0.000 description 2
- 101100101239 Mus musculus Txk gene Proteins 0.000 description 2
- 102100023955 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial Human genes 0.000 description 2
- 102100021506 NADH-ubiquinone oxidoreductase chain 4 Human genes 0.000 description 2
- 206010029488 Nodular melanoma Diseases 0.000 description 2
- 108091028043 Nucleic acid sequence Proteins 0.000 description 2
- KJWZYMMLVHIVSU-IYCNHOCDSA-N PGK1 Chemical compound CCCCC[C@H](O)\C=C\[C@@H]1[C@@H](CCCCCCC(O)=O)C(=O)CC1=O KJWZYMMLVHIVSU-IYCNHOCDSA-N 0.000 description 2
- 102100034539 Peptidyl-prolyl cis-trans isomerase A Human genes 0.000 description 2
- 102100028251 Phosphoglycerate kinase 1 Human genes 0.000 description 2
- 102100033953 Protein PRRC2B Human genes 0.000 description 2
- 102100029929 Protein dopey-2 Human genes 0.000 description 2
- 102100021672 Pumilio homolog 1 Human genes 0.000 description 2
- 102100031713 Splicing factor 3A subunit 1 Human genes 0.000 description 2
- 102100023155 Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial Human genes 0.000 description 2
- 102100026144 Transferrin receptor protein 1 Human genes 0.000 description 2
- 101710075829 VPS37A Proteins 0.000 description 2
- 102100034324 Vacuolar protein sorting-associated protein 37A Human genes 0.000 description 2
- 230000003321 amplification Effects 0.000 description 2
- 230000000692 anti-sense effect Effects 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 239000013060 biological fluid Substances 0.000 description 2
- 229960002271 cobimetinib Drugs 0.000 description 2
- RESIMIUSNACMNW-BXRWSSRYSA-N cobimetinib fumarate Chemical compound OC(=O)\C=C\C(O)=O.C1C(O)([C@H]2NCCCC2)CN1C(=O)C1=CC=C(F)C(F)=C1NC1=CC=C(I)C=C1F.C1C(O)([C@H]2NCCCC2)CN1C(=O)C1=CC=C(F)C(F)=C1NC1=CC=C(I)C=C1F RESIMIUSNACMNW-BXRWSSRYSA-N 0.000 description 2
- 238000013211 curve analysis Methods 0.000 description 2
- 208000030381 cutaneous melanoma Diseases 0.000 description 2
- 238000011161 development Methods 0.000 description 2
- 239000007850 fluorescent dye Substances 0.000 description 2
- 102000006602 glyceraldehyde-3-phosphate dehydrogenase Human genes 0.000 description 2
- 108020004445 glyceraldehyde-3-phosphate dehydrogenase Proteins 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 229940083118 mekinist Drugs 0.000 description 2
- 201000000032 nodular malignant melanoma Diseases 0.000 description 2
- 238000003199 nucleic acid amplification method Methods 0.000 description 2
- 230000037361 pathway Effects 0.000 description 2
- 229960002621 pembrolizumab Drugs 0.000 description 2
- 238000011422 pharmacological therapy Methods 0.000 description 2
- 238000001959 radiotherapy Methods 0.000 description 2
- 238000003753 real-time PCR Methods 0.000 description 2
- 239000013074 reference sample Substances 0.000 description 2
- 238000003757 reverse transcription PCR Methods 0.000 description 2
- 230000002441 reversible effect Effects 0.000 description 2
- 201000003708 skin melanoma Diseases 0.000 description 2
- 229940081616 tafinlar Drugs 0.000 description 2
- 238000012549 training Methods 0.000 description 2
- 229940055760 yervoy Drugs 0.000 description 2
- 229940034727 zelboraf Drugs 0.000 description 2
- FDKXTQMXEQVLRF-ZHACJKMWSA-N (E)-dacarbazine Chemical compound CN(C)\N=N\c1[nH]cnc1C(N)=O FDKXTQMXEQVLRF-ZHACJKMWSA-N 0.000 description 1
- 101150106899 28 gene Proteins 0.000 description 1
- 101100005789 Caenorhabditis elegans cdk-4 gene Proteins 0.000 description 1
- 102000053642 Catalytic RNA Human genes 0.000 description 1
- 108090000994 Catalytic RNA Proteins 0.000 description 1
- 108010058546 Cyclin D1 Proteins 0.000 description 1
- 102000053602 DNA Human genes 0.000 description 1
- 206010072449 Desmoplastic melanoma Diseases 0.000 description 1
- 206010061818 Disease progression Diseases 0.000 description 1
- 238000002965 ELISA Methods 0.000 description 1
- 102100024165 G1/S-specific cyclin-D1 Human genes 0.000 description 1
- 102100039788 GTPase NRas Human genes 0.000 description 1
- 101000744505 Homo sapiens GTPase NRas Proteins 0.000 description 1
- 208000029966 Hutchinson Melanotic Freckle Diseases 0.000 description 1
- 102100040018 Interferon alpha-2 Human genes 0.000 description 1
- 108010079944 Interferon-alpha2b Proteins 0.000 description 1
- 102000043136 MAP kinase family Human genes 0.000 description 1
- 108091054455 MAP kinase family Proteins 0.000 description 1
- 108091034117 Oligonucleotide Proteins 0.000 description 1
- 102000014160 PTEN Phosphohydrolase Human genes 0.000 description 1
- 108010011536 PTEN Phosphohydrolase Proteins 0.000 description 1
- 208000003251 Pruritus Diseases 0.000 description 1
- 208000029567 RASopathy Diseases 0.000 description 1
- 108091028664 Ribonucleotide Proteins 0.000 description 1
- 208000000453 Skin Neoplasms Diseases 0.000 description 1
- 206010042553 Superficial spreading melanoma stage unspecified Diseases 0.000 description 1
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 description 1
- 206010000583 acral lentiginous melanoma Diseases 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 238000013473 artificial intelligence Methods 0.000 description 1
- 238000001574 biopsy Methods 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 210000005266 circulating tumour cell Anatomy 0.000 description 1
- 238000007635 classification algorithm Methods 0.000 description 1
- 238000012790 confirmation Methods 0.000 description 1
- 229960002465 dabrafenib Drugs 0.000 description 1
- 229960003901 dacarbazine Drugs 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 238000009795 derivation Methods 0.000 description 1
- 238000012631 diagnostic technique Methods 0.000 description 1
- 230000009266 disease activity Effects 0.000 description 1
- 230000005750 disease progression Effects 0.000 description 1
- 210000000981 epithelium Anatomy 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000003633 gene expression assay Methods 0.000 description 1
- 238000011223 gene expression profiling Methods 0.000 description 1
- 230000003463 hyperproliferative effect Effects 0.000 description 1
- 229940091204 imlygic Drugs 0.000 description 1
- 230000008938 immune dysregulation Effects 0.000 description 1
- 238000003119 immunoblot Methods 0.000 description 1
- 238000003364 immunohistochemistry Methods 0.000 description 1
- 238000001114 immunoprecipitation Methods 0.000 description 1
- 238000010348 incorporation Methods 0.000 description 1
- 208000011080 lentigo maligna melanoma Diseases 0.000 description 1
- 230000000670 limiting effect Effects 0.000 description 1
- 230000004777 loss-of-function mutation Effects 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 108020004999 messenger RNA Proteins 0.000 description 1
- 238000010208 microarray analysis Methods 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 201000003731 mucosal melanoma Diseases 0.000 description 1
- 230000000869 mutational effect Effects 0.000 description 1
- 238000010606 normalization Methods 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 230000036961 partial effect Effects 0.000 description 1
- 238000005192 partition Methods 0.000 description 1
- 210000005259 peripheral blood Anatomy 0.000 description 1
- 239000011886 peripheral blood Substances 0.000 description 1
- 229920001184 polypeptide Polymers 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 208000037821 progressive disease Diseases 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 230000002285 radioactive effect Effects 0.000 description 1
- 208000016691 refractory malignant neoplasm Diseases 0.000 description 1
- 238000010839 reverse transcription Methods 0.000 description 1
- 239000002336 ribonucleotide Substances 0.000 description 1
- 125000002652 ribonucleotide group Chemical group 0.000 description 1
- 108091092562 ribozyme Proteins 0.000 description 1
- 238000011270 sentinel node biopsy Methods 0.000 description 1
- 201000000849 skin cancer Diseases 0.000 description 1
- 208000030457 superficial spreading melanoma Diseases 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
- 229940126585 therapeutic drug Drugs 0.000 description 1
- 229960004066 trametinib Drugs 0.000 description 1
- 238000010200 validation analysis Methods 0.000 description 1
- 238000011179 visual inspection Methods 0.000 description 1
- 238000012800 visualization Methods 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57407—Specifically defined cancers
- G01N33/5743—Specifically defined cancers of skin, e.g. melanoma
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/5308—Immunoassay; Biospecific binding assay; Materials therefor for analytes not provided for elsewhere, e.g. nucleic acids, uric acid, worms, mites
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
- G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2563/00—Nucleic acid detection characterized by the use of physical, structural and functional properties
- C12Q2563/107—Nucleic acid detection characterized by the use of physical, structural and functional properties fluorescence
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/118—Prognosis of disease development
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/56—Staging of a disease; Further complications associated with the disease
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/60—Complex ways of combining multiple protein biomarkers for diagnosis
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/70—Mechanisms involved in disease identification
- G01N2800/7023—(Hyper)proliferation
- G01N2800/7028—Cancer
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Pathology (AREA)
- Analytical Chemistry (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- Oncology (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Cell Biology (AREA)
- General Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- Hospice & Palliative Care (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Tropical Medicine & Parasitology (AREA)
- Dermatology (AREA)
- Mycology (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762511058P | 2017-05-25 | 2017-05-25 | |
| PCT/US2018/033658 WO2018217627A1 (en) | 2017-05-25 | 2018-05-21 | Methods for melanoma detection |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2920288T3 true ES2920288T3 (es) | 2022-08-02 |
Family
ID=62620988
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES18731615T Active ES2920288T3 (es) | 2017-05-25 | 2018-05-21 | Procedimientos para la detección de melanoma |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US20180340934A1 (enExample) |
| EP (1) | EP3631017B1 (enExample) |
| JP (1) | JP7227964B2 (enExample) |
| KR (1) | KR102763004B1 (enExample) |
| CN (1) | CN111315897B (enExample) |
| AU (1) | AU2018273844B2 (enExample) |
| BR (1) | BR112019024481A2 (enExample) |
| CA (1) | CA3064732A1 (enExample) |
| DK (1) | DK3631017T3 (enExample) |
| ES (1) | ES2920288T3 (enExample) |
| IL (1) | IL270787B2 (enExample) |
| MX (1) | MX2019014026A (enExample) |
| PL (1) | PL3631017T3 (enExample) |
| WO (1) | WO2018217627A1 (enExample) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR112019024481A2 (pt) | 2017-05-25 | 2020-07-14 | Liquid Biopsy Research LLC | métodos para detecção de melanoma |
| US20210108259A1 (en) | 2019-10-10 | 2021-04-15 | Liquid Biopsy Research LLC | Compositions, methods and kits for biological sample and rna stabilization |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2614946A1 (en) * | 2005-01-07 | 2006-07-13 | The Johns Hopkins University | Biomarkers for melanoma |
| US7615349B2 (en) * | 2006-09-07 | 2009-11-10 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Melanoma gene signature |
| EP2080140B1 (en) * | 2006-11-03 | 2013-04-24 | Baylor Research Institute | Diagnosis of metastatic melanoma and monitoring indicators of immunosuppression through blood leukocyte microarray analysis |
| EP2092075A2 (en) * | 2006-11-06 | 2009-08-26 | Source Precision Medicine, Inc. | Gene expression profiling for identification, monitoring and treatment of melanoma |
| US20110070582A1 (en) * | 2008-11-03 | 2011-03-24 | Source Precision Medicine, Inc. d/b/d Source MDX | Gene Expression Profiling for Predicting the Response to Immunotherapy and/or the Survivability of Melanoma Subjects |
| US20110091384A1 (en) * | 2009-10-13 | 2011-04-21 | The Johns Hopkins University | Biomarker for identification of melanoma tumor cells |
| US20140045915A1 (en) * | 2010-08-31 | 2014-02-13 | The General Hospital Corporation | Cancer-related biological materials in microvesicles |
| CN104470920A (zh) * | 2012-07-03 | 2015-03-25 | 通益制药有限公司 | 固态形式的维罗菲尼胆碱盐 |
| AU2015317893B2 (en) * | 2014-09-15 | 2021-05-20 | Clifton Life Sciences LLC | Compositions, methods and kits for diagnosis of a gastroenteropancreatic neuroendocrine neoplasm |
| BR112019024481A2 (pt) | 2017-05-25 | 2020-07-14 | Liquid Biopsy Research LLC | métodos para detecção de melanoma |
-
2018
- 2018-05-21 BR BR112019024481-6A patent/BR112019024481A2/pt unknown
- 2018-05-21 CN CN201880049298.1A patent/CN111315897B/zh active Active
- 2018-05-21 JP JP2020516379A patent/JP7227964B2/ja active Active
- 2018-05-21 MX MX2019014026A patent/MX2019014026A/es unknown
- 2018-05-21 EP EP18731615.3A patent/EP3631017B1/en active Active
- 2018-05-21 KR KR1020197038285A patent/KR102763004B1/ko active Active
- 2018-05-21 CA CA3064732A patent/CA3064732A1/en active Pending
- 2018-05-21 ES ES18731615T patent/ES2920288T3/es active Active
- 2018-05-21 WO PCT/US2018/033658 patent/WO2018217627A1/en not_active Ceased
- 2018-05-21 US US15/984,935 patent/US20180340934A1/en not_active Abandoned
- 2018-05-21 PL PL18731615.3T patent/PL3631017T3/pl unknown
- 2018-05-21 AU AU2018273844A patent/AU2018273844B2/en active Active
- 2018-05-21 DK DK18731615.3T patent/DK3631017T3/da active
-
2019
- 2019-11-20 IL IL270787A patent/IL270787B2/en unknown
-
2021
- 2021-09-30 US US17/490,433 patent/US12399179B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| DK3631017T3 (da) | 2022-06-20 |
| JP7227964B2 (ja) | 2023-02-22 |
| EP3631017A1 (en) | 2020-04-08 |
| MX2019014026A (es) | 2020-08-03 |
| PL3631017T3 (pl) | 2022-09-26 |
| WO2018217627A1 (en) | 2018-11-29 |
| IL270787B2 (en) | 2023-08-01 |
| AU2018273844A1 (en) | 2019-12-19 |
| JP2020524524A (ja) | 2020-08-20 |
| US20180340934A1 (en) | 2018-11-29 |
| BR112019024481A2 (pt) | 2020-07-14 |
| IL270787B1 (en) | 2023-04-01 |
| KR102763004B1 (ko) | 2025-02-04 |
| EP3631017B1 (en) | 2022-03-23 |
| CN111315897B (zh) | 2024-10-22 |
| KR20200030034A (ko) | 2020-03-19 |
| US12399179B2 (en) | 2025-08-26 |
| IL270787A (en) | 2020-01-30 |
| CN111315897A (zh) | 2020-06-19 |
| AU2018273844B2 (en) | 2024-11-14 |
| US20230022236A1 (en) | 2023-01-26 |
| CA3064732A1 (en) | 2018-11-29 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP7186700B2 (ja) | 腫瘍抑制ｆｏｘｏ活性を酸化ストレスから区別する方法 | |
| KR101437718B1 (ko) | 위암의 예후 예측용 마커 및 이를 이용하는 위암의 예후 예측 방법 | |
| Kim et al. | Detection of plasma BRAFV600E mutation is associated with lung metastasis in papillary thyroid carcinomas | |
| ES3013599T3 (en) | Compositions, methods and kits for diagnosis of a gastroenteropancreatic neuroendocrine neoplasm | |
| ES2893469T3 (es) | Puntuaciones de riesgo basadas en la expresión de la variante 7 de la fosfodiesterasa 4D humana | |
| ES2742840T3 (es) | Biomarcadores de micro-ARN para identificar el riesgo y/o diagnosticar tumor pulmonar | |
| US11993816B2 (en) | Circulating microRNA as biomarkers for endometriosis | |
| US20180230545A1 (en) | Method for the prediction of progression of bladder cancer | |
| ES2947946T3 (es) | Métodos para predecir el riesgo de metástasis en melanoma cutáneo | |
| JP2024523848A (ja) | 癌検出方法、キットおよびシステム | |
| Baba et al. | PRAME expression as a potential biomarker for hematogenous recurrence of esophageal squamous cell carcinoma | |
| ES2916450T3 (es) | Método para la detección de discrasia de células plasmáticas | |
| CN107614696A (zh) | 基因表现图谱以及将其应用于乳癌医疗之方法 | |
| JP2019529351A (ja) | 食道癌を診断するおよび治療するための方法 | |
| Usmani et al. | MiR-16: A novel hereditary marker in breast cancer and their offspring | |
| ES2920288T3 (es) | Procedimientos para la detección de melanoma | |
| Wu et al. | Long non-coding RNA Loc344887 is a potential prognostic biomarker in non-small cell lung cancer | |
| US12371749B2 (en) | Molecular pathogenesis of microcarcinoma of the thyroid | |
| CN112813167B (zh) | 标志物linc01977及其应用 | |
| HK40017741A (en) | Methods for melanoma detection | |
| HK40017741B (en) | Methods for melanoma detection | |
| US20250354219A1 (en) | Methods for neuroendocrine cancer detection in saliva | |
| YILMAZ et al. | CIRCULATING MICRORNA-101-3P AND MICRORNA-21-5P AS NON-INVASIVE BIOMARKERS IN THE DIAGNOSIS, RISK, PROGNOSIS AND SURVIVAL OF LARYNX CANCER | |
| Sutanto | Deregulated Expression of SPARCL1, EDIL3 and HEY2 in Primary Colorectal Carcinoma and Corresponding Liver Metastasis | |
| Shahat et al. | Evaluation of miR-146a Urinary Level as a Marker for Recurrence of Superficial Bladder Cancer after Transurethral Resection of Bladder Tumor (TUR-BT) |