JP2020528274A5 - - Google Patents
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- JP2020528274A5 JP2020528274A5 JP2020502711A JP2020502711A JP2020528274A5 JP 2020528274 A5 JP2020528274 A5 JP 2020528274A5 JP 2020502711 A JP2020502711 A JP 2020502711A JP 2020502711 A JP2020502711 A JP 2020502711A JP 2020528274 A5 JP2020528274 A5 JP 2020528274A5
- Authority
- JP
- Japan
- Prior art keywords
- splicing variants
- subject
- expression level
- nr4a1
- biomarkers
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 238000000034 method Methods 0.000 claims 31
- 239000000090 biomarker Substances 0.000 claims 20
- 101001109700 Homo sapiens Nuclear receptor subfamily 4 group A member 1 Proteins 0.000 claims 16
- 102100022679 Nuclear receptor subfamily 4 group A member 1 Human genes 0.000 claims 16
- -1 P1AS2 Proteins 0.000 claims 16
- 239000000523 sample Substances 0.000 claims 12
- 208000021161 Plasma cell disease Diseases 0.000 claims 11
- 101150050047 BHLHE40 gene Proteins 0.000 claims 10
- 102100026191 Class E basic helix-loop-helix protein 40 Human genes 0.000 claims 10
- 102100029269 Coatomer subunit alpha Human genes 0.000 claims 10
- 241000761389 Copa Species 0.000 claims 10
- 102100028138 F-box/WD repeat-containing protein 7 Human genes 0.000 claims 10
- 101710105178 F-box/WD repeat-containing protein 7 Proteins 0.000 claims 10
- 102100036703 Guanine nucleotide-binding protein subunit alpha-13 Human genes 0.000 claims 10
- 101000978381 Homo sapiens C-C motif chemokine 14 Proteins 0.000 claims 10
- 101000770458 Homo sapiens Coatomer subunit alpha Proteins 0.000 claims 10
- 101001072481 Homo sapiens Guanine nucleotide-binding protein subunit alpha-13 Proteins 0.000 claims 10
- 101001056180 Homo sapiens Induced myeloid leukemia cell differentiation protein Mcl-1 Proteins 0.000 claims 10
- 101000624540 Homo sapiens Leucine-tRNA ligase, mitochondrial Proteins 0.000 claims 10
- 101000583839 Homo sapiens Muscleblind-like protein 1 Proteins 0.000 claims 10
- 101001076431 Homo sapiens NF-kappa-B inhibitor zeta Proteins 0.000 claims 10
- 101000728236 Homo sapiens Polycomb group protein ASXL1 Proteins 0.000 claims 10
- 101001028703 Homo sapiens Probable JmjC domain-containing histone demethylation protein 2C Proteins 0.000 claims 10
- 101000933604 Homo sapiens Protein BTG2 Proteins 0.000 claims 10
- 101000654257 Homo sapiens SCY1-like protein 2 Proteins 0.000 claims 10
- 101000687735 Homo sapiens SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2 Proteins 0.000 claims 10
- 101000587438 Homo sapiens Serine/arginine-rich splicing factor 5 Proteins 0.000 claims 10
- 101000891084 Homo sapiens T-cell activation Rho GTPase-activating protein Proteins 0.000 claims 10
- 101000596277 Homo sapiens TSC22 domain family protein 3 Proteins 0.000 claims 10
- 101000801209 Homo sapiens Transducin-like enhancer protein 4 Proteins 0.000 claims 10
- 101000761725 Homo sapiens Ubiquitin-conjugating enzyme E2 J1 Proteins 0.000 claims 10
- 108091058560 IL8 Proteins 0.000 claims 10
- 102100026539 Induced myeloid leukemia cell differentiation protein Mcl-1 Human genes 0.000 claims 10
- 102000004890 Interleukin-8 Human genes 0.000 claims 10
- 108090001007 Interleukin-8 Proteins 0.000 claims 10
- 102100023342 Leucine-tRNA ligase, mitochondrial Human genes 0.000 claims 10
- 108091007767 MALAT1 Proteins 0.000 claims 10
- 102100030965 Muscleblind-like protein 1 Human genes 0.000 claims 10
- 102100026009 NF-kappa-B inhibitor zeta Human genes 0.000 claims 10
- 102100029799 Polycomb group protein ASXL1 Human genes 0.000 claims 10
- 102100037169 Probable JmjC domain-containing histone demethylation protein 2C Human genes 0.000 claims 10
- 102100026034 Protein BTG2 Human genes 0.000 claims 10
- 102100031698 SCY1-like protein 2 Human genes 0.000 claims 10
- 102100024795 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2 Human genes 0.000 claims 10
- 102100029703 Serine/arginine-rich splicing factor 5 Human genes 0.000 claims 10
- 102100040346 T-cell activation Rho GTPase-activating protein Human genes 0.000 claims 10
- 102100035260 TSC22 domain family protein 3 Human genes 0.000 claims 10
- 102100033763 Transducin-like enhancer protein 4 Human genes 0.000 claims 10
- 102100024860 Ubiquitin-conjugating enzyme E2 J1 Human genes 0.000 claims 10
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims 7
- 102100022528 5'-AMP-activated protein kinase catalytic subunit alpha-1 Human genes 0.000 claims 7
- 108700039887 Essential Genes Proteins 0.000 claims 7
- 101000677993 Homo sapiens 5'-AMP-activated protein kinase catalytic subunit alpha-1 Proteins 0.000 claims 7
- 101000988424 Homo sapiens cAMP-specific 3',5'-cyclic phosphodiesterase 4B Proteins 0.000 claims 7
- 102100029168 cAMP-specific 3',5'-cyclic phosphodiesterase 4B Human genes 0.000 claims 7
- 239000002299 complementary DNA Substances 0.000 claims 7
- 239000003795 chemical substances by application Substances 0.000 claims 5
- 108090000623 proteins and genes Proteins 0.000 claims 5
- 102000004169 proteins and genes Human genes 0.000 claims 4
- 101100296720 Dictyostelium discoideum Pde4 gene Proteins 0.000 claims 3
- 206010061819 Disease recurrence Diseases 0.000 claims 3
- 101100082610 Plasmodium falciparum (isolate 3D7) PDEdelta gene Proteins 0.000 claims 3
- 201000010099 disease Diseases 0.000 claims 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- 230000001613 neoplastic effect Effects 0.000 claims 3
- 238000010606 normalization Methods 0.000 claims 3
- 101000653679 Homo sapiens Translationally-controlled tumor protein Proteins 0.000 claims 2
- ZBZXYUYUUDZCNB-UHFFFAOYSA-N N-cyclohexa-1,3-dien-1-yl-N-phenyl-4-[4-(N-[4-[4-(N-[4-[4-(N-phenylanilino)phenyl]phenyl]anilino)phenyl]phenyl]anilino)phenyl]aniline Chemical compound C1=CCCC(N(C=2C=CC=CC=2)C=2C=CC(=CC=2)C=2C=CC(=CC=2)N(C=2C=CC=CC=2)C=2C=CC(=CC=2)C=2C=CC(=CC=2)N(C=2C=CC=CC=2)C=2C=CC(=CC=2)C=2C=CC(=CC=2)N(C=2C=CC=CC=2)C=2C=CC=CC=2)=C1 ZBZXYUYUUDZCNB-UHFFFAOYSA-N 0.000 claims 2
- 108020004711 Nucleic Acid Probes Proteins 0.000 claims 2
- 102100029887 Translationally-controlled tumor protein Human genes 0.000 claims 2
- 210000004369 blood Anatomy 0.000 claims 2
- 239000008280 blood Substances 0.000 claims 2
- 239000002853 nucleic acid probe Substances 0.000 claims 2
- 210000002381 plasma Anatomy 0.000 claims 2
- 210000004180 plasmocyte Anatomy 0.000 claims 2
- 230000000750 progressive effect Effects 0.000 claims 2
- 210000002966 serum Anatomy 0.000 claims 2
- 238000002626 targeted therapy Methods 0.000 claims 2
- 102100027831 14-3-3 protein theta Human genes 0.000 claims 1
- 102100040685 14-3-3 protein zeta/delta Human genes 0.000 claims 1
- 102100029511 26S proteasome regulatory subunit 6B Human genes 0.000 claims 1
- 102100028104 39S ribosomal protein L19, mitochondrial Human genes 0.000 claims 1
- 102100040881 60S acidic ribosomal protein P0 Human genes 0.000 claims 1
- 102100022289 60S ribosomal protein L13a Human genes 0.000 claims 1
- 102100026611 Alpha-1,2-mannosyltransferase ALG9 Human genes 0.000 claims 1
- 102100027314 Beta-2-microglobulin Human genes 0.000 claims 1
- 102100026031 Beta-glucuronidase Human genes 0.000 claims 1
- 101100421140 Danio rerio selenon gene Proteins 0.000 claims 1
- 102100021699 Eukaryotic translation initiation factor 3 subunit B Human genes 0.000 claims 1
- 101000723543 Homo sapiens 14-3-3 protein theta Proteins 0.000 claims 1
- 101000964898 Homo sapiens 14-3-3 protein zeta/delta Proteins 0.000 claims 1
- 101001125524 Homo sapiens 26S proteasome regulatory subunit 6B Proteins 0.000 claims 1
- 101001079803 Homo sapiens 39S ribosomal protein L19, mitochondrial Proteins 0.000 claims 1
- 101000673456 Homo sapiens 60S acidic ribosomal protein P0 Proteins 0.000 claims 1
- 101000681240 Homo sapiens 60S ribosomal protein L13a Proteins 0.000 claims 1
- 101000756632 Homo sapiens Actin, cytoplasmic 1 Proteins 0.000 claims 1
- 101000717828 Homo sapiens Alpha-1,2-mannosyltransferase ALG9 Proteins 0.000 claims 1
- 101000937544 Homo sapiens Beta-2-microglobulin Proteins 0.000 claims 1
- 101000933465 Homo sapiens Beta-glucuronidase Proteins 0.000 claims 1
- 101000896557 Homo sapiens Eukaryotic translation initiation factor 3 subunit B Proteins 0.000 claims 1
- 101000988834 Homo sapiens Hypoxanthine-guanine phosphoribosyltransferase Proteins 0.000 claims 1
- 101000969546 Homo sapiens Mortality factor 4-like protein 1 Proteins 0.000 claims 1
- 101001111252 Homo sapiens NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial Proteins 0.000 claims 1
- 101001109052 Homo sapiens NADH-ubiquinone oxidoreductase chain 4 Proteins 0.000 claims 1
- 101001068630 Homo sapiens Protein PRRC2B Proteins 0.000 claims 1
- 101000863956 Homo sapiens Protein dopey-2 Proteins 0.000 claims 1
- 101000616974 Homo sapiens Pumilio homolog 1 Proteins 0.000 claims 1
- 101000707546 Homo sapiens Splicing factor 3A subunit 1 Proteins 0.000 claims 1
- 101000685323 Homo sapiens Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial Proteins 0.000 claims 1
- 101000762938 Homo sapiens TOX high mobility group box family member 4 Proteins 0.000 claims 1
- 101000835093 Homo sapiens Transferrin receptor protein 1 Proteins 0.000 claims 1
- 206010020631 Hypergammaglobulinaemia benign monoclonal Diseases 0.000 claims 1
- 208000019758 Hypergammaglobulinemia Diseases 0.000 claims 1
- 102100021395 Mortality factor 4-like protein 1 Human genes 0.000 claims 1
- 102100023955 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial Human genes 0.000 claims 1
- 102100021506 NADH-ubiquinone oxidoreductase chain 4 Human genes 0.000 claims 1
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 1
- 229940079156 Proteasome inhibitor Drugs 0.000 claims 1
- 102100033953 Protein PRRC2B Human genes 0.000 claims 1
- 102100029929 Protein dopey-2 Human genes 0.000 claims 1
- 102100021672 Pumilio homolog 1 Human genes 0.000 claims 1
- 102100031713 Splicing factor 3A subunit 1 Human genes 0.000 claims 1
- 102100023155 Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial Human genes 0.000 claims 1
- 102100026749 TOX high mobility group box family member 4 Human genes 0.000 claims 1
- 102100026144 Transferrin receptor protein 1 Human genes 0.000 claims 1
- 101710075829 VPS37A Proteins 0.000 claims 1
- 102100034324 Vacuolar protein sorting-associated protein 37A Human genes 0.000 claims 1
- 102000006602 glyceraldehyde-3-phosphate dehydrogenase Human genes 0.000 claims 1
- 108020004445 glyceraldehyde-3-phosphate dehydrogenase Proteins 0.000 claims 1
- 238000009396 hybridization Methods 0.000 claims 1
- 238000007477 logistic regression Methods 0.000 claims 1
- 201000005328 monoclonal gammopathy of uncertain significance Diseases 0.000 claims 1
- 201000000050 myeloid neoplasm Diseases 0.000 claims 1
- 238000001050 pharmacotherapy Methods 0.000 claims 1
- 239000003207 proteasome inhibitor Substances 0.000 claims 1
- 230000009257 reactivity Effects 0.000 claims 1
- 239000013074 reference sample Substances 0.000 claims 1
- 230000035945 sensitivity Effects 0.000 claims 1
- 208000024891 symptom Diseases 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762535419P | 2017-07-21 | 2017-07-21 | |
| US62/535,419 | 2017-07-21 | ||
| PCT/US2018/042712 WO2019018540A1 (en) | 2017-07-21 | 2018-07-18 | METHODS FOR DETECTION OF PLASMOCYTE DYSGLOBULINEMIA |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020528274A JP2020528274A (ja) | 2020-09-24 |
| JP2020528274A5 true JP2020528274A5 (enExample) | 2021-08-26 |
| JP7223741B2 JP7223741B2 (ja) | 2023-02-16 |
Family
ID=63244986
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020502711A Active JP7223741B2 (ja) | 2017-07-21 | 2018-07-18 | 形質細胞疾患の検出方法 |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US20190025311A1 (enExample) |
| EP (1) | EP3655553B1 (enExample) |
| JP (1) | JP7223741B2 (enExample) |
| KR (1) | KR102785072B1 (enExample) |
| CN (1) | CN111194356B (enExample) |
| AU (1) | AU2018304242B2 (enExample) |
| BR (1) | BR112020000791A2 (enExample) |
| CA (1) | CA3067730A1 (enExample) |
| DK (1) | DK3655553T3 (enExample) |
| ES (1) | ES2916450T3 (enExample) |
| IL (1) | IL271465B2 (enExample) |
| MX (1) | MX2020000785A (enExample) |
| PL (1) | PL3655553T3 (enExample) |
| WO (1) | WO2019018540A1 (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2916450T3 (es) | 2017-07-21 | 2022-07-01 | Liquid Biopsy Res Llc | Método para la detección de discrasia de células plasmáticas |
| US20210108259A1 (en) | 2019-10-10 | 2021-04-15 | Liquid Biopsy Research LLC | Compositions, methods and kits for biological sample and rna stabilization |
| CN111349705A (zh) * | 2020-03-18 | 2020-06-30 | 昆明医科大学 | circASXL1作为肺癌诊断标志物及其运用 |
| US20230203587A1 (en) * | 2020-05-29 | 2023-06-29 | Exosome Diagnostics, Inc. | Use of microvesicle signature for the diagnosis and treatment of kidney transplant rejection |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1461448A2 (en) | 2001-11-07 | 2004-09-29 | The Board Of Trustees Of The University Of Arkansas | Diagnosis prognosis and identification of potential therapeutic targets of multiple myeloma based on gene expression profiling |
| JP2004313167A (ja) * | 2003-02-24 | 2004-11-11 | Joji Inasawa | 薬剤耐性マーカーおよびその利用 |
| CA3002661C (en) * | 2004-05-21 | 2022-03-15 | The Board Of Trustees Of The University Of Arkansas | Use of gene expression profiling to predict survival in cancer patient |
| JP5904569B2 (ja) | 2005-06-08 | 2016-04-13 | ミレニアム ファーマシューティカルズ， インコーポレイテッドＭｉｌｌｅｎｎｉｕｍ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． | 癌治療を受けている患者の同定、判定および処置のための方法 |
| US20120015906A1 (en) * | 2009-01-02 | 2012-01-19 | Shaughnessy Jr John D | Uses of bortezomib in predicting survival in multiple myeloma patients |
| WO2011152884A2 (en) * | 2010-06-04 | 2011-12-08 | Board Of Trustees Of The University Of Arkansas | 14 gene signature distinguishes between multiple myeloma subtypes |
| WO2013155048A1 (en) * | 2012-04-10 | 2013-10-17 | University Of Utah Research Foundation | Compositions and methods for diagnosing and classifying multiple myeloma |
| ES2916450T3 (es) | 2017-07-21 | 2022-07-01 | Liquid Biopsy Res Llc | Método para la detección de discrasia de células plasmáticas |
-
2018
- 2018-07-18 ES ES18755985T patent/ES2916450T3/es active Active
- 2018-07-18 EP EP18755985.1A patent/EP3655553B1/en active Active
- 2018-07-18 MX MX2020000785A patent/MX2020000785A/es unknown
- 2018-07-18 WO PCT/US2018/042712 patent/WO2019018540A1/en not_active Ceased
- 2018-07-18 CA CA3067730A patent/CA3067730A1/en active Pending
- 2018-07-18 CN CN201880061441.9A patent/CN111194356B/zh active Active
- 2018-07-18 AU AU2018304242A patent/AU2018304242B2/en active Active
- 2018-07-18 DK DK18755985.1T patent/DK3655553T3/da active
- 2018-07-18 BR BR112020000791-9A patent/BR112020000791A2/pt unknown
- 2018-07-18 KR KR1020207004033A patent/KR102785072B1/ko active Active
- 2018-07-18 US US16/039,041 patent/US20190025311A1/en not_active Abandoned
- 2018-07-18 JP JP2020502711A patent/JP7223741B2/ja active Active
- 2018-07-18 PL PL18755985.1T patent/PL3655553T3/pl unknown
-
2019
- 2019-12-16 IL IL271465A patent/IL271465B2/en unknown
-
2021
- 2021-10-14 US US17/501,168 patent/US12366575B2/en active Active
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