JP2020522249A5 - - Google Patents
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- Publication number
- JP2020522249A5 JP2020522249A5 JP2019565890A JP2019565890A JP2020522249A5 JP 2020522249 A5 JP2020522249 A5 JP 2020522249A5 JP 2019565890 A JP2019565890 A JP 2019565890A JP 2019565890 A JP2019565890 A JP 2019565890A JP 2020522249 A5 JP2020522249 A5 JP 2020522249A5
- Authority
- JP
- Japan
- Prior art keywords
- hpiv3
- amino acid
- acid sequence
- rsv
- protein
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 241000712003 Human respirovirus 3 Species 0.000 claims description 76
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 48
- 108091006027 G proteins Proteins 0.000 claims description 21
- 102000030782 GTP binding Human genes 0.000 claims description 21
- 108091000058 GTP-Binding Proteins 0.000 claims description 21
- 210000005220 cytoplasmic tail Anatomy 0.000 claims description 18
- 108090000623 proteins and genes Proteins 0.000 claims description 13
- 230000028993 immune response Effects 0.000 claims description 12
- 241000726041 Human respirovirus 1 Species 0.000 claims description 10
- 238000000034 method Methods 0.000 claims description 7
- 101150008820 HN gene Proteins 0.000 claims description 6
- 101710133291 Hemagglutinin-neuraminidase Proteins 0.000 claims description 6
- 239000002299 complementary DNA Substances 0.000 claims description 6
- 108020004707 nucleic acids Proteins 0.000 claims description 6
- 102000039446 nucleic acids Human genes 0.000 claims description 6
- 150000007523 nucleic acids Chemical class 0.000 claims description 6
- 230000002163 immunogen Effects 0.000 claims description 5
- 239000000203 mixture Substances 0.000 claims description 5
- 101150034814 F gene Proteins 0.000 claims description 4
- 101150062031 L gene Proteins 0.000 claims description 4
- 101150084044 P gene Proteins 0.000 claims description 4
- 241000700605 Viruses Species 0.000 claims description 4
- 238000004113 cell culture Methods 0.000 claims description 4
- 108700026220 vif Genes Proteins 0.000 claims description 4
- 108010068327 4-hydroxyphenylpyruvate dioxygenase Proteins 0.000 claims description 2
- 241000712005 Bovine respirovirus 3 Species 0.000 claims description 2
- 101710117545 C protein Proteins 0.000 claims description 2
- 101001065501 Escherichia phage MS2 Lysis protein Proteins 0.000 claims description 2
- 101900208483 Human parainfluenza 3 virus Fusion glycoprotein F0 Proteins 0.000 claims description 2
- AYFVYJQAPQTCCC-GBXIJSLDSA-N L-threonine Chemical group C[C@@H](O)[C@H](N)C(O)=O AYFVYJQAPQTCCC-GBXIJSLDSA-N 0.000 claims description 2
- 101710085938 Matrix protein Proteins 0.000 claims description 2
- 101710127721 Membrane protein Proteins 0.000 claims description 2
- 108091028043 Nucleic acid sequence Proteins 0.000 claims description 2
- 101710141454 Nucleoprotein Proteins 0.000 claims description 2
- 102100034574 P protein Human genes 0.000 claims description 2
- 108010015724 Prephenate Dehydratase Proteins 0.000 claims description 2
- AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 claims description 2
- 239000004473 Threonine Substances 0.000 claims description 2
- 230000002238 attenuated effect Effects 0.000 claims description 2
- 210000004027 cell Anatomy 0.000 claims description 2
- 239000003937 drug carrier Substances 0.000 claims description 2
- 210000005260 human cell Anatomy 0.000 claims description 2
- 208000015181 infectious disease Diseases 0.000 claims description 2
- 230000002458 infectious effect Effects 0.000 claims description 2
- 239000002773 nucleotide Substances 0.000 claims description 2
- 125000003729 nucleotide group Chemical group 0.000 claims description 2
- 125000001500 prolyl group Chemical group [H]N1C([H])(C(=O)[*])C([H])([H])C([H])([H])C1([H])[H] 0.000 claims description 2
- 230000001681 protective effect Effects 0.000 claims description 2
- 230000000241 respiratory effect Effects 0.000 claims description 2
- 230000029812 viral genome replication Effects 0.000 claims description 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 5
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023063846A JP2023093566A (ja) | 2017-05-29 | 2023-04-11 | Ｒｓｖ ｇを発現する組換えキメラウシ／ヒトパラインフルエンザウイルス３およびその使用法 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762512111P | 2017-05-29 | 2017-05-29 | |
| US62/512,111 | 2017-05-29 | ||
| PCT/US2018/034848 WO2018222573A1 (en) | 2017-05-29 | 2018-05-29 | Recombinant chimeric bovine/human parainfluenza virus 3 expressing rsv g and its use |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023063846A Division JP2023093566A (ja) | 2017-05-29 | 2023-04-11 | Ｒｓｖ ｇを発現する組換えキメラウシ／ヒトパラインフルエンザウイルス３およびその使用法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020522249A JP2020522249A (ja) | 2020-07-30 |
| JP2020522249A5 true JP2020522249A5 (cg-RX-API-DMAC7.html) | 2021-05-27 |
| JP7314059B2 JP7314059B2 (ja) | 2023-07-25 |
Family
ID=62685166
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019565890A Active JP7314059B2 (ja) | 2017-05-29 | 2018-05-29 | Ｒｓｖ ｇを発現する組換えキメラウシ／ヒトパラインフルエンザウイルス３およびその使用法 |
| JP2023063846A Pending JP2023093566A (ja) | 2017-05-29 | 2023-04-11 | Ｒｓｖ ｇを発現する組換えキメラウシ／ヒトパラインフルエンザウイルス３およびその使用法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023063846A Pending JP2023093566A (ja) | 2017-05-29 | 2023-04-11 | Ｒｓｖ ｇを発現する組換えキメラウシ／ヒトパラインフルエンザウイルス３およびその使用法 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US11273214B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP3630173A1 (cg-RX-API-DMAC7.html) |
| JP (2) | JP7314059B2 (cg-RX-API-DMAC7.html) |
| CN (1) | CN110996998A (cg-RX-API-DMAC7.html) |
| CA (1) | CA3064267A1 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2018222573A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN117729935A (zh) * | 2021-04-27 | 2024-03-19 | 美国政府(由卫生和人类服务部的部长所代表) | 表达sars-cov-2刺突蛋白的重组嵌合牛/人副流感病毒3及其用途 |
| CN118302191A (zh) | 2021-11-30 | 2024-07-05 | 圣诺菲·帕斯图尔公司 | 基于病毒载体的人偏肺病毒疫苗 |
| CN115925822B (zh) * | 2022-09-01 | 2024-01-09 | 广州源博医药科技有限公司 | 一种重组蛋白及其在制备呼吸道合胞病毒疫苗中的应用 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH01501357A (ja) * | 1986-01-14 | 1989-05-18 | ユニバ−シテイ・オブ・ノ−ス・カロライナ | ヒト呼吸器系ウイルス用ワクチン |
| US7192593B2 (en) | 1997-05-23 | 2007-03-20 | The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Use of recombinant parainfluenza viruses (PIVs) as vectors to protect against infection and disease caused by PIV and other human pathogens |
| KR100702523B1 (ko) * | 1997-05-23 | 2007-04-04 | 더 가번먼트 오브 더 유나이티드 스테이츠 오브 아메리카, 에즈 레프리젠티드 바이 더 디파트먼트 오브 헬쓰 앤드 휴먼 서비시즈 | 클로닝된 뉴클레오타이드 서열로부터 약독화된파라인플루엔자 바이러스를 제조하는 방법 |
| US7201907B1 (en) | 1997-05-23 | 2007-04-10 | The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Attenuated human-bovine chimeric parainfluenza virus(PIV) vaccines |
| US7208161B1 (en) | 1997-05-23 | 2007-04-24 | The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Production of attenuated parainfluenza virus vaccines from cloned nucleotide sequences |
| US20030082209A1 (en) | 2000-07-05 | 2003-05-01 | Skiadopoulos Mario H. | Attenuated human-bovine chimeric parainfluenza virus (PIV) vaccines |
| US7632508B2 (en) | 1997-05-23 | 2009-12-15 | The United States Of America | Attenuated human-bovine chimeric parainfluenza virus (PIV) vaccines |
| US7250171B1 (en) | 1997-05-23 | 2007-07-31 | United States Of America As Represented By The Dept. Of Health & Human Services | Construction and use of recombinant parainfluenza viruses expressing a chimeric glycoprotein |
| IL144831A0 (en) * | 1999-12-10 | 2002-06-30 | Us Health | USE OF RECOMBINANT PARAINFLUENZA VIRUSES (PIVs) AS VECTORS TO PROTECT AGAINST INFECTION AND DISEASE CAUSED BY PIV AND OTHER HUMAN PATHOGENS |
| US6764685B1 (en) | 2000-03-21 | 2004-07-20 | Medimmune Vaccines, Inc. | Recombinant parainfluenza virus expression systems and vaccines |
| EP1485488A4 (en) * | 2002-02-21 | 2005-03-02 | Sinai School Medicine | RECOMBINANT EXPRESSION SYSTEMS FOR MINUSTRAN VIRUS RNA AND VACCINES |
| AU2003219837B2 (en) | 2002-02-21 | 2009-10-29 | Erasmus University Medical Center Rotterdam | Metapneumovirus strains and their use in vaccine formulations and as vector for expression of antigenic sequences |
| KR101187955B1 (ko) | 2003-04-25 | 2012-10-08 | 비로노바티브 비브이 | 메타뉴모바이러스 유래 이종 항원을 포함하는 재조합파라인플루엔자 바이러스 발현 시스템 및 백신 |
| US9216212B2 (en) * | 2005-08-05 | 2015-12-22 | University Of Massachusetts | Virus-like particles as vaccines for paramyxovirus |
| WO2009012155A2 (en) | 2007-07-13 | 2009-01-22 | Medimmune, Llc | Preparation of negative-stranded rna viruses by electroporation |
| US10654898B2 (en) * | 2015-01-20 | 2020-05-19 | The United States of America, as represented by the Secretary, Department of Health and Human Serices | Recombinant human/bovine parainfluenza virus 3 (B/HPIV3) expressing a chimeric RSV/BPIV3 F protein and uses thereof |
| WO2017100759A1 (en) * | 2015-12-11 | 2017-06-15 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Recombinant respiratory syncytial virus strains with mutations in the m2-2 orf providing a range of attenuation phenotypes |
-
2018
- 2018-05-29 WO PCT/US2018/034848 patent/WO2018222573A1/en not_active Ceased
- 2018-05-29 CN CN201880048358.8A patent/CN110996998A/zh active Pending
- 2018-05-29 CA CA3064267A patent/CA3064267A1/en active Pending
- 2018-05-29 US US16/616,873 patent/US11273214B2/en active Active
- 2018-05-29 EP EP18733056.8A patent/EP3630173A1/en active Pending
- 2018-05-29 JP JP2019565890A patent/JP7314059B2/ja active Active
-
2022
- 2022-02-01 US US17/590,631 patent/US11975063B2/en active Active
-
2023
- 2023-04-11 JP JP2023063846A patent/JP2023093566A/ja active Pending
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