JP2020521767A5 - - Google Patents
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- Publication number
- JP2020521767A5 JP2020521767A5 JP2019565399A JP2019565399A JP2020521767A5 JP 2020521767 A5 JP2020521767 A5 JP 2020521767A5 JP 2019565399 A JP2019565399 A JP 2019565399A JP 2019565399 A JP2019565399 A JP 2019565399A JP 2020521767 A5 JP2020521767 A5 JP 2020521767A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- pharmaceutically acceptable
- solvate
- acceptable salt
- tautomer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762510223P | 2017-05-23 | 2017-05-23 | |
| US62/510,223 | 2017-05-23 | ||
| PCT/US2018/033964 WO2018217809A1 (en) | 2017-05-23 | 2018-05-22 | Pyrazole magl inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020521767A JP2020521767A (ja) | 2020-07-27 |
| JP2020521767A5 true JP2020521767A5 (enExample) | 2022-07-26 |
| JP7162622B2 JP7162622B2 (ja) | 2022-10-28 |
Family
ID=64397012
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019565399A Active JP7162622B2 (ja) | 2017-05-23 | 2018-05-22 | ピラゾールｍａｇｌ阻害剤 |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US11149037B2 (enExample) |
| EP (1) | EP3634404B1 (enExample) |
| JP (1) | JP7162622B2 (enExample) |
| KR (1) | KR20200010366A (enExample) |
| CN (1) | CN110678177B (enExample) |
| AU (1) | AU2018273888A1 (enExample) |
| BR (1) | BR112019024488A2 (enExample) |
| CA (1) | CA3065898A1 (enExample) |
| CL (1) | CL2019003398A1 (enExample) |
| CO (1) | CO2019013016A2 (enExample) |
| CR (1) | CR20190537A (enExample) |
| DO (1) | DOP2019000295A (enExample) |
| EA (1) | EA201992504A1 (enExample) |
| EC (1) | ECSP19083923A (enExample) |
| ES (1) | ES3005265T3 (enExample) |
| JO (1) | JOP20190267A1 (enExample) |
| MA (1) | MA50405A (enExample) |
| MX (1) | MX2019014041A (enExample) |
| NI (1) | NI201900120A (enExample) |
| PE (1) | PE20200293A1 (enExample) |
| PH (1) | PH12019502646A1 (enExample) |
| RU (1) | RU2019137094A (enExample) |
| WO (1) | WO2018217809A1 (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ627750A (en) | 2012-01-06 | 2016-11-25 | Abide Therapeutics Inc | Carbamate compounds and of making and using same |
| WO2017096315A1 (en) | 2015-12-02 | 2017-06-08 | The Scripps Research Institute | TRIAZOLE DAGL(α) INHIBITORS |
| JOP20190105A1 (ar) * | 2016-11-16 | 2019-05-09 | Lundbeck La Jolla Research Center Inc | مثبطات أحادي أسيل جليسرول ليباز (magl) |
| JOP20190107A1 (ar) | 2016-11-16 | 2019-05-09 | Lundbeck La Jolla Research Center Inc | مثبطات أحادي أسيل جليسرول ليباز (magl) |
| MY200738A (en) | 2017-05-23 | 2024-01-13 | H Lundbeck As | Pyrazole magl inhibitors |
| US10927105B1 (en) | 2017-05-23 | 2021-02-23 | Lundbeck La Jolla Research Center, Inc. | Pyrazole MAGL inhibitors |
| JOP20190267A1 (ar) | 2017-05-23 | 2019-11-18 | Lundbeck La Jolla Research Center Inc | مثبطات بيرازول magl |
| EP3737680A1 (en) | 2018-01-08 | 2020-11-18 | F. Hoffmann-La Roche AG | Octahydropyrido[1,2-alpha]pyrazines as magl inhibitors |
| CN114072405A (zh) | 2019-07-03 | 2022-02-18 | 豪夫迈·罗氏有限公司 | 杂环单酰基甘油脂肪酶(magl)抑制剂 |
| KR20220034104A (ko) * | 2019-07-09 | 2022-03-17 | 에프. 호프만-라 로슈 아게 | 신규 헤테로고리 화합물 |
| US20240101552A1 (en) * | 2020-09-18 | 2024-03-28 | Shanghai Pharmaceuticals Holding Co., Ltd. | Carbonyl heterocyclic compound and application thereof |
| KR20230142745A (ko) | 2021-01-29 | 2023-10-11 | 세딜라 테라퓨틱스, 인크. | Cdk2 억제제 및 그의 사용 방법 |
| TW202317560A (zh) | 2021-06-26 | 2023-05-01 | 美商賽迪拉治療股份有限公司 | Ｃｄｋ２抑制劑及其使用方法 |
| IL313987A (en) | 2021-12-29 | 2024-08-01 | Psy Therapeutics Inc | Inhibiting monoacylglycerol lipase (magl) |
| WO2024168426A1 (en) | 2023-02-13 | 2024-08-22 | Apogee Pharmaceuticals, Inc. | Small molecules as monoacylglycerol lipase (magl) inhibitors, compositions and use thereof |
| WO2025221154A1 (en) | 2024-04-17 | 2025-10-23 | Captor Therapeutics S.A. | Klhdc2 (kelch domain-containing protein 2) ligase ligands |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3308130A (en) | 1962-04-26 | 1967-03-07 | Du Pont | N-disubstituted carbamyl pyrazoles |
| US7589202B2 (en) | 2000-08-14 | 2009-09-15 | Ortho Mcneil Pharmaceutical, Inc. | Substituted pyrazoles |
| US6727364B2 (en) | 2001-04-30 | 2004-04-27 | The Procter & Gamble Company | Triazole compounds useful in treating diseases associated with unwanted cytokine activity |
| JP4422488B2 (ja) * | 2002-02-19 | 2010-02-24 | テバ ファーマシューティカル インダストリーズ リミティド | アトルバスタチンヘミカルシウム溶媒和物の脱溶媒和法及び有機溶媒を本質的に含まないアトルバスタチンヘミカルシウム |
| SE0300705D0 (sv) | 2003-03-14 | 2003-03-14 | Biolipox Ab | New compounds |
| JPWO2008023720A1 (ja) | 2006-08-23 | 2010-01-14 | アステラス製薬株式会社 | ウレア化合物又はその塩 |
| AU2009330821B2 (en) | 2008-12-24 | 2015-06-11 | Bial - Portela & Ca, S.A. | Pharmaceutical compounds |
| AU2012240154A1 (en) | 2011-04-06 | 2013-10-17 | The Scripps Research Institute | N1- and N2-carbamoyl-1,2,3-triazole serine hydrolase inhibitors and methods |
| CN103130723B (zh) | 2011-11-30 | 2015-01-14 | 成都地奥制药集团有限公司 | 一种多聚(adp-核糖)聚合酶抑制剂 |
| US9624170B2 (en) | 2013-12-26 | 2017-04-18 | Takeda Pharmaceutical Company Limited | 4-(piperrazin-1-yl)-pyrrolidin-2-one compounds as monoacylglycerol lipase (MAGL) inhibitors |
| WO2015179559A2 (en) * | 2014-05-21 | 2015-11-26 | Abide Therapeutics, Inc. | Pyrazole compounds and methods of making and using same |
| GB2543994B (en) * | 2014-07-23 | 2020-10-07 | Baker Hughes Inc | System and method for downhole organic scale monitoring and intervention in a production well |
| US10570146B2 (en) | 2014-07-25 | 2020-02-25 | Northeastern University | Urea/carbamates FAAH MAGL or dual FAAH/MAGL inhibitors and uses thereof |
| MX375424B (es) | 2015-07-31 | 2025-03-06 | Pfizer | Derivados de 1,1,1-trifluoro-3-hidroxipropan-2-il carbamato y derivados de 1,1,1-trifluoro-4- hidroxibutan-2-il carbamato como inhibidores de magl |
| WO2017087858A1 (en) | 2015-11-20 | 2017-05-26 | Abide Therapeutics, Inc. | Pyrazole compounds and methods of making and using same |
| US10519134B2 (en) | 2015-11-20 | 2019-12-31 | Lundbeck La Jolla Research Center, Inc. | Pyrazole compounds and methods of making and using same |
| US10323038B2 (en) | 2015-11-20 | 2019-06-18 | Abide Therapeutics, Inc. | Pyrazole compounds and methods of making and using same |
| WO2017096315A1 (en) | 2015-12-02 | 2017-06-08 | The Scripps Research Institute | TRIAZOLE DAGL(α) INHIBITORS |
| MY200738A (en) | 2017-05-23 | 2024-01-13 | H Lundbeck As | Pyrazole magl inhibitors |
| US10927105B1 (en) | 2017-05-23 | 2021-02-23 | Lundbeck La Jolla Research Center, Inc. | Pyrazole MAGL inhibitors |
| JOP20190267A1 (ar) | 2017-05-23 | 2019-11-18 | Lundbeck La Jolla Research Center Inc | مثبطات بيرازول magl |
-
2017
- 2017-06-16 JO JOP/2019/0267A patent/JOP20190267A1/ar unknown
-
2018
- 2018-05-22 CA CA3065898A patent/CA3065898A1/en not_active Abandoned
- 2018-05-22 CN CN201880033866.9A patent/CN110678177B/zh active Active
- 2018-05-22 AU AU2018273888A patent/AU2018273888A1/en not_active Abandoned
- 2018-05-22 US US16/615,746 patent/US11149037B2/en active Active
- 2018-05-22 JP JP2019565399A patent/JP7162622B2/ja active Active
- 2018-05-22 BR BR112019024488-3A patent/BR112019024488A2/pt not_active Application Discontinuation
- 2018-05-22 EP EP18805515.6A patent/EP3634404B1/en active Active
- 2018-05-22 PE PE2019002453A patent/PE20200293A1/es unknown
- 2018-05-22 EA EA201992504A patent/EA201992504A1/ru unknown
- 2018-05-22 RU RU2019137094A patent/RU2019137094A/ru not_active Application Discontinuation
- 2018-05-22 ES ES18805515T patent/ES3005265T3/es active Active
- 2018-05-22 MX MX2019014041A patent/MX2019014041A/es unknown
- 2018-05-22 CR CR20190537A patent/CR20190537A/es unknown
- 2018-05-22 MA MA050405A patent/MA50405A/fr unknown
- 2018-05-22 WO PCT/US2018/033964 patent/WO2018217809A1/en not_active Ceased
- 2018-05-22 KR KR1020197037406A patent/KR20200010366A/ko not_active Withdrawn
-
2019
- 2019-11-20 DO DO2019000295A patent/DOP2019000295A/es unknown
- 2019-11-21 CL CL2019003398A patent/CL2019003398A1/es unknown
- 2019-11-21 CO CONC2019/0013016A patent/CO2019013016A2/es unknown
- 2019-11-22 NI NI201900120A patent/NI201900120A/es unknown
- 2019-11-22 PH PH12019502646A patent/PH12019502646A1/en unknown
- 2019-11-25 EC ECSENADI201983923A patent/ECSP19083923A/es unknown