JP2020521460A - Ｏ−糖タンパク質のためのプロテアーゼ及び結合ポリペプチド - Google Patents

Ｏ−糖タンパク質のためのプロテアーゼ及び結合ポリペプチド Download PDF

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Publication number
JP2020521460A
JP2020521460A JP2019565178A JP2019565178A JP2020521460A JP 2020521460 A JP2020521460 A JP 2020521460A JP 2019565178 A JP2019565178 A JP 2019565178A JP 2019565178 A JP2019565178 A JP 2019565178A JP 2020521460 A JP2020521460 A JP 2020521460A
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Prior art keywords
seq
polypeptide
amino acid
acid sequence
sequence
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JP2019565178A
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Japanese (ja)
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JP2020521460A5 (enExample
Inventor
レオ、フレドリク
ルード、ロルフ
ビョーク、ステファン
メジャレ、マリン
オルソン、フレドリク
Original Assignee
ジェノビス エービー
ジェノビス エービー
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Priority claimed from GBGB1708476.5A external-priority patent/GB201708476D0/en
Priority claimed from GBGB1708471.6A external-priority patent/GB201708471D0/en
Priority claimed from GBGB1806655.5A external-priority patent/GB201806655D0/en
Application filed by ジェノビス エービー, ジェノビス エービー filed Critical ジェノビス エービー
Publication of JP2020521460A publication Critical patent/JP2020521460A/ja
Publication of JP2020521460A5 publication Critical patent/JP2020521460A5/ja
Priority to JP2023065981A priority Critical patent/JP7557896B2/ja
Pending legal-status Critical Current

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/24—Metalloendopeptidases (3.4.24)
    • C12Y304/24057—O-Sialoglycoprotein endopeptidase (3.4.24.57), i.e. glycoprotease
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/84—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving inorganic compounds or pH
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/924—Hydrolases (3) acting on glycosyl compounds (3.2)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/95—Proteinases, i.e. endopeptidases (3.4.21-3.4.99)
    • G01N2333/952—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from bacteria

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Immunology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • Pathology (AREA)
  • Inorganic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
JP2019565178A 2017-05-26 2018-05-25 Ｏ−糖タンパク質のためのプロテアーゼ及び結合ポリペプチド Pending JP2020521460A (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2023065981A JP7557896B2 (ja) 2017-05-26 2023-04-13 Ｏ－糖タンパク質のためのプロテアーゼ及び結合ポリペプチド

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
GB1708476.5 2017-05-26
GBGB1708476.5A GB201708476D0 (en) 2017-05-26 2017-05-26 Tools for glycan analysis
GB1708471.6 2017-05-26
GBGB1708471.6A GB201708471D0 (en) 2017-05-26 2017-05-26 Polypeptide
GBGB1806655.5A GB201806655D0 (en) 2018-04-24 2018-04-24 Polypeptide
GB1806655.5 2018-04-24
PCT/EP2018/063832 WO2018215656A1 (en) 2017-05-26 2018-05-25 Protease and binding polypeptide for o-glycoproteins

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2023065981A Division JP7557896B2 (ja) 2017-05-26 2023-04-13 Ｏ－糖タンパク質のためのプロテアーゼ及び結合ポリペプチド

Publications (2)

Publication Number Publication Date
JP2020521460A true JP2020521460A (ja) 2020-07-27
JP2020521460A5 JP2020521460A5 (enExample) 2021-07-26

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Application Number Title Priority Date Filing Date
JP2019565178A Pending JP2020521460A (ja) 2017-05-26 2018-05-25 Ｏ−糖タンパク質のためのプロテアーゼ及び結合ポリペプチド
JP2019565188A Active JP7195008B2 (ja) 2017-05-26 2018-05-25 グリカン分析のための酵素
JP2023065981A Active JP7557896B2 (ja) 2017-05-26 2023-04-13 Ｏ－糖タンパク質のためのプロテアーゼ及び結合ポリペプチド

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JP2019565188A Active JP7195008B2 (ja) 2017-05-26 2018-05-25 グリカン分析のための酵素
JP2023065981A Active JP7557896B2 (ja) 2017-05-26 2023-04-13 Ｏ－糖タンパク質のためのプロテアーゼ及び結合ポリペプチド

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Country Link
US (3) US11584922B2 (enExample)
EP (2) EP3630968B8 (enExample)
JP (3) JP2020521460A (enExample)
KR (2) KR102609790B1 (enExample)
CN (2) CN111183220B (enExample)
AU (2) AU2018272400B2 (enExample)
CA (2) CA3063815A1 (enExample)
DK (2) DK3630968T3 (enExample)
ES (2) ES2986557T3 (enExample)
FI (2) FI3630967T3 (enExample)
IL (2) IL270950B2 (enExample)
PL (2) PL3630968T3 (enExample)
PT (2) PT3630967T (enExample)
WO (2) WO2018215657A1 (enExample)

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WO2024118481A1 (en) * 2022-11-28 2024-06-06 Amgen Inc. Method of processing etanercept

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PL3630968T3 (pl) 2017-05-26 2024-10-07 Genovis Ab Enzymy do analizy glikanów
AU2020301037A1 (en) * 2019-07-03 2022-02-03 Palleon Pharmaceuticals Inc. Recombinant human sialidases, sialidase fusion proteins, and methods of using the same
CN112795583A (zh) * 2020-11-16 2021-05-14 上海大学 重组唾液酸外切酶的制备方法、表达基因、重组表达载体及构建方法
WO2023114931A1 (en) * 2021-12-15 2023-06-22 Danisco Us Inc. Compositions and methods involving proteases specific for mannose-modified proteins
US20260092921A1 (en) 2024-09-27 2026-04-02 Roche Diagnostics Gmbh Mutated neuroaminidase

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WO2009129086A2 (en) 2008-04-18 2009-10-22 New England Biolabs, Inc. Endoglycosidases that cleave o-linked glycans
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WO2010111691A2 (en) 2009-03-27 2010-09-30 Life Technologies Corp Conjugates of biomolecules to nanoparticles
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AU2017214441B2 (en) 2016-02-04 2021-08-19 Genovis Ab New Streptococcal proteases
PL3630968T3 (pl) * 2017-05-26 2024-10-07 Genovis Ab Enzymy do analizy glikanów

Non-Patent Citations (2)

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"DEFINITION hypothetical protein Amuc_1119 [Akkermansia muciniphila ATCC BAA-835]", DATABASE GENBANK [ONLINE], ACCESSION ACD04945, JPN6022020643, 11 December 2013 (2013-12-11), ISSN: 0004942657 *
"DEFINITION SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:ACD04945.1}", DATABASE UNIPROT [ONLINE], ACCESSION B2UR60, JPN6022020644, 10 May 2017 (2017-05-10), ISSN: 0004942656 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2024118481A1 (en) * 2022-11-28 2024-06-06 Amgen Inc. Method of processing etanercept

Also Published As

Publication number Publication date
US20200087643A1 (en) 2020-03-19
CA3063828A1 (en) 2018-11-29
CA3063815A1 (en) 2018-11-29
IL270949B2 (en) 2025-06-01
PL3630968T3 (pl) 2024-10-07
PL3630967T3 (pl) 2024-11-18
EP3630967B8 (en) 2024-07-17
WO2018215656A9 (en) 2019-03-14
EP3630967A1 (en) 2020-04-08
CN111183221B (zh) 2024-04-09
IL270949A (en) 2020-01-30
DK3630967T3 (da) 2024-08-19
JP2023103233A (ja) 2023-07-26
CN111183220B (zh) 2024-03-22
US20200172889A1 (en) 2020-06-04
JP7195008B2 (ja) 2022-12-23
JP2020522242A (ja) 2020-07-30
WO2018215657A9 (en) 2019-03-14
AU2018272984A1 (en) 2019-12-05
ES2986910T3 (es) 2024-11-13
PT3630967T (pt) 2024-08-21
WO2018215656A1 (en) 2018-11-29
AU2018272400A1 (en) 2019-12-05
AU2018272984B2 (en) 2024-05-23
IL270949B1 (en) 2025-02-01
US12448614B2 (en) 2025-10-21
AU2018272400B2 (en) 2024-06-13
JP7557896B2 (ja) 2024-09-30
DK3630968T3 (da) 2024-07-29
ES2986557T3 (es) 2024-11-11
US11584922B2 (en) 2023-02-21
EP3630968B1 (en) 2024-05-29
IL270950A (en) 2020-01-30
EP3630968A1 (en) 2020-04-08
CN111183221A (zh) 2020-05-19
CN111183220A (zh) 2020-05-19
FI3630967T3 (fi) 2024-08-12
US20230212543A1 (en) 2023-07-06
WO2018215657A1 (en) 2018-11-29
EP3630967B1 (en) 2024-06-12
IL270950B2 (en) 2025-06-01
PT3630968T (pt) 2024-07-30
FI3630968T3 (fi) 2024-07-24
KR20200011955A (ko) 2020-02-04
KR102608876B1 (ko) 2023-11-30
EP3630968B8 (en) 2024-07-03
IL270950B1 (en) 2025-02-01
KR102609790B1 (ko) 2023-12-04
KR20200010322A (ko) 2020-01-30
US12529044B2 (en) 2026-01-20

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