JP2020520963A5 - - Google Patents
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- JP2020520963A5 JP2020520963A5 JP2019564822A JP2019564822A JP2020520963A5 JP 2020520963 A5 JP2020520963 A5 JP 2020520963A5 JP 2019564822 A JP2019564822 A JP 2019564822A JP 2019564822 A JP2019564822 A JP 2019564822A JP 2020520963 A5 JP2020520963 A5 JP 2020520963A5
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- pharmaceutical composition
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- 239000008194 pharmaceutical composition Substances 0.000 claims 14
- 150000003839 salts Chemical class 0.000 claims 4
- 239000011780 sodium chloride Substances 0.000 claims 4
- 230000035533 AUC Effects 0.000 claims 1
- 206010002855 Anxiety Diseases 0.000 claims 1
- 206010057666 Anxiety disease Diseases 0.000 claims 1
- 206010010144 Completed suicide Diseases 0.000 claims 1
- 206010011971 Decreased interest Diseases 0.000 claims 1
- 206010012374 Depressed mood Diseases 0.000 claims 1
- 206010016256 Fatigue Diseases 0.000 claims 1
- 206010022437 Insomnia Diseases 0.000 claims 1
- 206010022998 Irritability Diseases 0.000 claims 1
- 210000002381 Plasma Anatomy 0.000 claims 1
- 206010041349 Somnolence Diseases 0.000 claims 1
- 230000036506 anxiety Effects 0.000 claims 1
- 230000036528 appetite Effects 0.000 claims 1
- 235000019789 appetite Nutrition 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 201000009916 postpartum depression Diseases 0.000 claims 1
- 230000003252 repetitive Effects 0.000 claims 1
- 230000002142 suicide Effects 0.000 claims 1
- 230000004584 weight gain Effects 0.000 claims 1
- 235000019786 weight gain Nutrition 0.000 claims 1
- 230000004580 weight loss Effects 0.000 claims 1
Claims (12)
- 約１ｍｇ〜約３０ｍｇのガボキサドールまたはその薬学的に許容される塩を含む、分娩後うつを処置するための医薬組成物。
- 約１０ｍｇのガボキサドールまたはその薬学的に許容される塩を含む、請求項１に記載の医薬組成物。
- 約１５ｍｇのガボキサドールまたはその薬学的に許容される塩を含む、請求項１に記載の医薬組成物。
- 約２０ｍｇのガボキサドールまたはその薬学的に許容される塩を含む、請求項１に記載の医薬組成物。
- 医薬組成物の投与後６時間の患者のインビボ血漿プロファイルが５０％を超えて減少するものである、請求項１〜４のいずれか一項に記載の医薬組成物。
- 医薬組成物の投与後６時間の患者のＡＵＣ６−１２が投与された用量の７５％未満である、請求項１〜４のいずれか一項に記載の医薬組成物。
- 投与後６時間を超える患者における改善を提供する、請求項１〜６のいずれか一項に記載の医薬組成物。
- 投与後８時間を超える患者における改善を提供する、請求項１〜６のいずれか一項に記載の医薬組成物。
- 投与後少なくとも１２時間患者における改善を提供する、請求項１〜６のいずれか一項に記載の医薬組成物。
- 投与後１２時間を超える患者における改善を提供する、請求項１〜６のいずれか一項に記載の医薬組成物。
- 悲しみ、嗜眠、抑うつ気分、不安感、全てまたはほとんど全ての活動における関心低下、体重増加または体重減少をもたらす食欲の顕著な増加または減少、不眠症、易怒性、疲労、無価値感、無力感、集中力欠如および死または自殺について繰り返し考えることから成る群から選択される症状の頻度の低減を提供する、請求項１〜１０のいずれか一項に記載の医薬組成物。
- １日１回、１日２回、１日３回または隔日投与される、請求項１〜１１のいずれか一項に記載の医薬組成物。
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023009149A JP2023061957A (ja) | 2017-05-24 | 2023-01-25 | 抑うつ障害の処置 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762510481P | 2017-05-24 | 2017-05-24 | |
| US62/510,481 | 2017-05-24 | ||
| US15/933,673 | 2018-03-23 | ||
| US15/933,673 US20180338959A1 (en) | 2017-05-24 | 2018-03-23 | Treatment of depressive disorders |
| PCT/US2018/033848 WO2018217718A1 (en) | 2017-05-24 | 2018-05-22 | Treatment of depressive disorders |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023009149A Division JP2023061957A (ja) | 2017-05-24 | 2023-01-25 | 抑うつ障害の処置 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2020520963A JP2020520963A (ja) | 2020-07-16 |
| JP2020520963A5 true JP2020520963A5 (ja) | 2021-07-26 |
Family
ID=64395877
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019564822A Pending JP2020520963A (ja) | 2017-05-24 | 2018-05-22 | 抑うつ障害の処置 |
| JP2023009149A Withdrawn JP2023061957A (ja) | 2017-05-24 | 2023-01-25 | 抑うつ障害の処置 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023009149A Withdrawn JP2023061957A (ja) | 2017-05-24 | 2023-01-25 | 抑うつ障害の処置 |
Country Status (10)
| Country | Link |
|---|---|
| US (4) | US20180338959A1 (ja) |
| EP (2) | EP3630065A4 (ja) |
| JP (2) | JP2020520963A (ja) |
| KR (1) | KR20200018485A (ja) |
| CN (2) | CN110996910A (ja) |
| AU (1) | AU2018272819A1 (ja) |
| CA (1) | CA3064299A1 (ja) |
| IL (1) | IL270781A (ja) |
| MX (1) | MX2019014024A (ja) |
| WO (1) | WO2018217718A1 (ja) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JOP20170059B1 (ar) | 2016-03-08 | 2021-08-17 | Sage Therapeutics Inc | ستيرويدات وتركيبات نشطة عصبيًا واستخداماتها |
| US10987303B2 (en) * | 2018-05-02 | 2021-04-27 | LifeMax Laboratories, Inc. | Extended release suspension formulation of lurasidone |
| MX2021005992A (es) | 2018-11-21 | 2021-09-14 | Certego Therapeutics Inc | Gaboxadol para reducir el riesgo de suicidio y para alivio rápido de la depresión. |
| JP2023526439A (ja) | 2020-05-20 | 2023-06-21 | セルテゴ セラピューティクス インコーポレイテッド | 精神障害の処置のための環重水素化ガボキサドールおよびその使用 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK270378A (da) | 1977-06-20 | 1978-12-21 | Krogsgaard Larsen P | Isoxazolderivater |
| US4362731A (en) | 1980-09-01 | 1982-12-07 | Sandoz Ltd. | Myotonolytic use of 4,5,6,7-tetrahydroisoxazolo [5,4-c] pyridin-3-ol and derivatives thereof |
| US4353910A (en) | 1981-11-27 | 1982-10-12 | Kefalas A/S | Derivatives of 4,5,6,7-tetrahydroisoxazolo [5,4-c] pyridine-3-one, pharmaceutical compositions and methods of treatment |
| AR031473A1 (es) * | 2000-11-20 | 2003-09-24 | Lundbeck & Co As H | Intensificadores de gaba en el tratamiento de enfermedades relacionadas con una reducida actividad neuroesteroide |
| US20020165217A1 (en) * | 2001-05-01 | 2002-11-07 | Pfizer Inc. | Combination treatment for anxiety and depression |
| WO2004112786A2 (en) * | 2003-06-25 | 2004-12-29 | H. Lundbeck A/S | Gaboxadol for treating depression and other affective disorders |
| US20050234093A1 (en) * | 2003-06-25 | 2005-10-20 | H. Lundbeck A/S | Treatment of depression and other affective disorders |
| CL2004001603A1 (es) * | 2003-06-25 | 2005-05-27 | Lundbeck & Co As H | Uso de gabaxadol para preparar un medicamento util para el tratamiento del dolor neuropatico. |
| US20080269278A1 (en) | 2004-04-02 | 2008-10-30 | H. Lundbeck A/S | Treatment of Impaired Respiratory Function with Gaboxadol |
| US20090048288A1 (en) * | 2007-08-13 | 2009-02-19 | H. Lundbeck A/S | Method of treating stress-mediated depression |
| US10628156B2 (en) * | 2013-07-09 | 2020-04-21 | Texas Instruments Incorporated | Vector SIMD VLIW data path architecture |
| JP2017516868A (ja) * | 2014-06-06 | 2017-06-22 | オービッド・セラピューティクス・インコーポレイテッドＯｖｉｄ Ｔｈｅｒａｐｅｕｔｉｃｓ， Ｉｎｃ． | 持続性抑制を増加させ、二次性不眠症を治療する方法 |
| PE20230735A1 (es) * | 2015-07-17 | 2023-05-03 | Ovid Therapeutics Inc | Metodos de tratamiento de trastornos del desarrollo con gaboxadol |
| WO2017027249A1 (en) * | 2015-08-11 | 2017-02-16 | Ovid Therapeutics Inc. | Methods of sedation and parenteral formulation for use during critical care treatment |
-
2018
- 2018-03-23 US US15/933,673 patent/US20180338959A1/en not_active Abandoned
- 2018-05-22 CN CN201880048161.4A patent/CN110996910A/zh active Pending
- 2018-05-22 CN CN202210735249.1A patent/CN115105499A/zh active Pending
- 2018-05-22 KR KR1020197038042A patent/KR20200018485A/ko not_active Application Discontinuation
- 2018-05-22 CA CA3064299A patent/CA3064299A1/en active Pending
- 2018-05-22 MX MX2019014024A patent/MX2019014024A/es unknown
- 2018-05-22 EP EP18805653.5A patent/EP3630065A4/en not_active Withdrawn
- 2018-05-22 EP EP21195602.4A patent/EP3939587A1/en not_active Withdrawn
- 2018-05-22 WO PCT/US2018/033848 patent/WO2018217718A1/en active Application Filing
- 2018-05-22 JP JP2019564822A patent/JP2020520963A/ja active Pending
- 2018-05-22 AU AU2018272819A patent/AU2018272819A1/en active Pending
- 2018-12-18 US US16/223,356 patent/US20190117633A1/en not_active Abandoned
-
2019
- 2019-11-20 IL IL270781A patent/IL270781A/en unknown
-
2020
- 2020-02-19 US US16/794,354 patent/US20200179351A1/en not_active Abandoned
-
2021
- 2021-08-18 US US17/405,525 patent/US20210379028A1/en active Pending
-
2023
- 2023-01-25 JP JP2023009149A patent/JP2023061957A/ja not_active Withdrawn
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