JP2020518596A5 - - Google Patents
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- JP2020518596A5 JP2020518596A5 JP2019559814A JP2019559814A JP2020518596A5 JP 2020518596 A5 JP2020518596 A5 JP 2020518596A5 JP 2019559814 A JP2019559814 A JP 2019559814A JP 2019559814 A JP2019559814 A JP 2019559814A JP 2020518596 A5 JP2020518596 A5 JP 2020518596A5
- Authority
- JP
- Japan
- Prior art keywords
- saiharusan
- herbal medicine
- extraction method
- chinese herbal
- antidepressant effect
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- XEKOWRVHYACXOJ-UHFFFAOYSA-N acetic acid ethyl ester Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 3
- 230000001430 anti-depressive Effects 0.000 description 2
- 239000000935 antidepressant agent Substances 0.000 description 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 241000411851 herbal medicine Species 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 230000001476 alcoholic Effects 0.000 description 1
- 230000003001 depressive Effects 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 230000002440 hepatic Effects 0.000 description 1
- 238000009776 industrial production Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 239000003208 petroleum Substances 0.000 description 1
- 238000003908 quality control method Methods 0.000 description 1
- 238000003809 water extraction Methods 0.000 description 1
Description
逍遥散は疏肝解鬱の古典漢方薬における有名な処方である。前期、本課題グループが有する二つの登録特許（201010110283.7と201110084715.6）は、酢酸エチルと石油エーテルによる抽出方法を採用し、逍遥散が明確な抗うつ効果を持つことが判明したが、工業化生産には潜在的な危険が多くあり、プロセスの制御性が低く、一方、逍遥散の元の処方には薬用材料種類が多く、また服用量が多く、品質のコントロールが困難であった。そこで、本発明は、逍遥散に対する研究に基づき、処方がより簡単で、プロセスがパイロット生産により適切なアルコール水抽出法で漢方薬エキスを調製し、その抗うつ効果の特徴を研究した。
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710947004.4A CN107625813A (zh) | 2017-10-12 | 2017-10-12 | 一种具有抗抑郁功效的中药提取物及其制备方法和应用 |
| CN201710947004.4 | 2017-10-12 | ||
| CN201810724541.7A CN108653405A (zh) | 2017-10-12 | 2018-07-04 | 一种具有抗抑郁功效的中药提取物及其制备方法和应用 |
| CN201810724541.7 | 2018-07-04 | ||
| PCT/CN2018/103870 WO2019072051A1 (zh) | 2017-10-12 | 2018-09-04 | 一种具有抗抑郁功效的中药提取物及其制备方法和应用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020518596A JP2020518596A (ja) | 2020-06-25 |
| JP2020518596A5 true JP2020518596A5 (ja) | 2021-02-12 |
| JP6880236B2 JP6880236B2 (ja) | 2021-06-02 |
Family
ID=61105399
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019559814A Active JP6880236B2 (ja) | 2017-10-12 | 2018-09-04 | うつ病に効果がある漢方薬エキス及びその調製方法と使用 |
Country Status (3)
| Country | Link |
|---|---|
| JP (1) | JP6880236B2 (ja) |
| CN (2) | CN107625813A (ja) |
| WO (1) | WO2019072051A1 (ja) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111665107A (zh) * | 2020-06-16 | 2020-09-15 | 湖南一方天江药业有限公司 | 一种便于定量提取的中药实验检验用提取装置 |
| CN114053337B (zh) * | 2020-07-30 | 2023-12-26 | 天士力医药集团股份有限公司 | 一种具有缓解精神及抗抑郁功效的中药组合物及其制备方法 |
| CN111973692B (zh) * | 2020-08-24 | 2022-01-21 | 江西普正制药股份有限公司 | 一种红花逍遥制剂及其制备方法、抗抑郁中的应用 |
| CN114191426B (zh) * | 2021-11-12 | 2023-11-10 | 成都中医药大学 | 一种柴胡当归薄荷复方提取物及其制备方法和用途 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1660403A (zh) * | 2005-01-20 | 2005-08-31 | 北京勃然制药有限公司 | 一种用于疏肝健脾、养血调经的消遥滴丸及其制备方法 |
| CN101732427B (zh) * | 2008-11-24 | 2012-12-12 | 广州白云山和记黄埔中药有限公司 | 预防和/或治疗抑郁症和更年期综合症的药物组合物 |
-
2017
- 2017-10-12 CN CN201710947004.4A patent/CN107625813A/zh active Pending
-
2018
- 2018-07-04 CN CN201810724541.7A patent/CN108653405A/zh active Pending
- 2018-09-04 JP JP2019559814A patent/JP6880236B2/ja active Active
- 2018-09-04 WO PCT/CN2018/103870 patent/WO2019072051A1/zh active Application Filing
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