JP2020518300A5 - - Google Patents
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- JP2020518300A5 JP2020518300A5 JP2019539960A JP2019539960A JP2020518300A5 JP 2020518300 A5 JP2020518300 A5 JP 2020518300A5 JP 2019539960 A JP2019539960 A JP 2019539960A JP 2019539960 A JP2019539960 A JP 2019539960A JP 2020518300 A5 JP2020518300 A5 JP 2020518300A5
- Authority
- JP
- Japan
- Prior art keywords
- maximum
- spinal cord
- region
- stimulation
- monoaminergic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 239000000556 agonist Substances 0.000 claims 46
- 230000000638 stimulation Effects 0.000 claims 38
- 230000001730 monoaminergic effect Effects 0.000 claims 37
- 210000000278 spinal cord Anatomy 0.000 claims 28
- 230000029058 respiratory gaseous exchange Effects 0.000 claims 13
- 210000000115 thoracic cavity Anatomy 0.000 claims 13
- 238000011282 treatment Methods 0.000 claims 13
- 210000000133 brain stem Anatomy 0.000 claims 12
- 210000005230 lumbar spinal cord Anatomy 0.000 claims 11
- 230000000241 respiratory effect Effects 0.000 claims 8
- 201000004193 respiratory failure Diseases 0.000 claims 8
- 208000004756 Respiratory Insufficiency Diseases 0.000 claims 6
- 206010011224 Cough Diseases 0.000 claims 5
- 210000004705 lumbosacral region Anatomy 0.000 claims 5
- 208000034972 Sudden Infant Death Diseases 0.000 claims 4
- 206010042440 Sudden infant death syndrome Diseases 0.000 claims 4
- 230000007383 nerve stimulation Effects 0.000 claims 4
- 230000009747 swallowing Effects 0.000 claims 4
- 206010002026 amyotrophic lateral sclerosis Diseases 0.000 claims 3
- 210000004556 brain Anatomy 0.000 claims 3
- 230000033001 locomotion Effects 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 208000015122 neurodegenerative disease Diseases 0.000 claims 3
- 230000036387 respiratory rate Effects 0.000 claims 3
- 230000000284 resting effect Effects 0.000 claims 3
- 208000020431 spinal cord injury Diseases 0.000 claims 3
- QJPPEMXOOWNICQ-UHFFFAOYSA-N 1-(2,3-dihydro-1,4-benzodioxin-5-yl)-4-(2,3-dihydro-1h-inden-2-yl)piperazine Chemical compound O1CCOC2=C1C=CC=C2N(CC1)CCN1C1CC2=CC=CC=C2C1 QJPPEMXOOWNICQ-UHFFFAOYSA-N 0.000 claims 2
- ASXGJMSKWNBENU-UHFFFAOYSA-N 8-OH-DPAT Chemical compound C1=CC(O)=C2CC(N(CCC)CCC)CCC2=C1 ASXGJMSKWNBENU-UHFFFAOYSA-N 0.000 claims 2
- GHWJEDJMOVUXEC-UHFFFAOYSA-N 9-chloro-5-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol Chemical compound C1NCCC=2C(Cl)=C(O)C(O)=CC=2C1C1=CC=CC=C1 GHWJEDJMOVUXEC-UHFFFAOYSA-N 0.000 claims 2
- 206010066131 Congenital central hypoventilation syndrome Diseases 0.000 claims 2
- 208000032319 Primary lateral sclerosis Diseases 0.000 claims 2
- 206010046298 Upper motor neurone lesion Diseases 0.000 claims 2
- 208000027418 Wounds and injury Diseases 0.000 claims 2
- 239000012190 activator Substances 0.000 claims 2
- 206010001053 acute respiratory failure Diseases 0.000 claims 2
- 230000006378 damage Effects 0.000 claims 2
- 208000014674 injury Diseases 0.000 claims 2
- 201000010901 lateral sclerosis Diseases 0.000 claims 2
- 208000005264 motor neuron disease Diseases 0.000 claims 2
- 210000000273 spinal nerve root Anatomy 0.000 claims 2
- 210000000779 thoracic wall Anatomy 0.000 claims 2
- SFLSHLFXELFNJZ-QMMMGPOBSA-N (-)-norepinephrine Chemical compound NC[C@H](O)C1=CC=C(O)C(O)=C1 SFLSHLFXELFNJZ-QMMMGPOBSA-N 0.000 claims 1
- FELGMEQIXOGIFQ-CYBMUJFWSA-N (3r)-9-methyl-3-[(2-methylimidazol-1-yl)methyl]-2,3-dihydro-1h-carbazol-4-one Chemical compound CC1=NC=CN1C[C@@H]1C(=O)C(C=2C(=CC=CC=2)N2C)=C2CC1 FELGMEQIXOGIFQ-CYBMUJFWSA-N 0.000 claims 1
- GOTMKOSCLKVOGG-OAHLLOKOSA-N (5R)-8-chloro-3-methyl-5-phenyl-1,2,4,5-tetrahydro-3-benzazepin-7-ol Chemical compound C1([C@@H]2C3=CC(O)=C(Cl)C=C3CCN(C2)C)=CC=CC=C1 GOTMKOSCLKVOGG-OAHLLOKOSA-N 0.000 claims 1
- WPVVMKYQOMJPIN-UHFFFAOYSA-N 1-(6-chloro-2-pyridinyl)-4-piperidinamine Chemical compound C1CC(N)CCN1C1=CC=CC(Cl)=N1 WPVVMKYQOMJPIN-UHFFFAOYSA-N 0.000 claims 1
- 239000003477 4 aminobutyric acid receptor stimulating agent Substances 0.000 claims 1
- ROLMZTIHUMKEAI-UHFFFAOYSA-N 4,5-difluoro-2-hydroxybenzonitrile Chemical compound OC1=CC(F)=C(F)C=C1C#N ROLMZTIHUMKEAI-UHFFFAOYSA-N 0.000 claims 1
- 206010001052 Acute respiratory distress syndrome Diseases 0.000 claims 1
- 206010001605 Alcohol poisoning Diseases 0.000 claims 1
- 208000024827 Alzheimer disease Diseases 0.000 claims 1
- 208000003870 Drug Overdose Diseases 0.000 claims 1
- 208000014094 Dystonic disease Diseases 0.000 claims 1
- 229940127427 Glycine Agonists Drugs 0.000 claims 1
- 208000023105 Huntington disease Diseases 0.000 claims 1
- WJAJPNHVVFWKKL-UHFFFAOYSA-N Methoxamine Chemical compound COC1=CC=C(OC)C(C(O)C(C)N)=C1 WJAJPNHVVFWKKL-UHFFFAOYSA-N 0.000 claims 1
- SBPRIAGPYFYCRT-UHFFFAOYSA-N N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-N-(2-pyridinyl)cyclohexanecarboxamide Chemical compound COC1=CC=CC=C1N1CCN(CCN(C(=O)C2CCCCC2)C=2N=CC=CC=2)CC1 SBPRIAGPYFYCRT-UHFFFAOYSA-N 0.000 claims 1
- 206010033296 Overdoses Diseases 0.000 claims 1
- 208000018737 Parkinson disease Diseases 0.000 claims 1
- GOTMKOSCLKVOGG-UHFFFAOYSA-N SCH 23390 Chemical compound C1N(C)CCC2=CC(Cl)=C(O)C=C2C1C1=CC=CC=C1 GOTMKOSCLKVOGG-UHFFFAOYSA-N 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- 210000000988 bone and bone Anatomy 0.000 claims 1
- 208000029028 brain injury Diseases 0.000 claims 1
- QWCRAEMEVRGPNT-UHFFFAOYSA-N buspirone Chemical compound C1C(=O)N(CCCCN2CCN(CC2)C=2N=CC=CN=2)C(=O)CC21CCCC2 QWCRAEMEVRGPNT-UHFFFAOYSA-N 0.000 claims 1
- 229960002495 buspirone Drugs 0.000 claims 1
- 206010008129 cerebral palsy Diseases 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 230000010339 dilation Effects 0.000 claims 1
- 229940052760 dopamine agonists Drugs 0.000 claims 1
- 239000003136 dopamine receptor stimulating agent Substances 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 206010013663 drug dependence Diseases 0.000 claims 1
- 231100000725 drug overdose Toxicity 0.000 claims 1
- 208000010118 dystonia Diseases 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 230000000302 ischemic effect Effects 0.000 claims 1
- FPCCSQOGAWCVBH-UHFFFAOYSA-N ketanserin Chemical compound C1=CC(F)=CC=C1C(=O)C1CCN(CCN2C(C3=CC=CC=C3NC2=O)=O)CC1 FPCCSQOGAWCVBH-UHFFFAOYSA-N 0.000 claims 1
- 229960005417 ketanserin Drugs 0.000 claims 1
- 229960005192 methoxamine Drugs 0.000 claims 1
- 229960002748 norepinephrine Drugs 0.000 claims 1
- SFLSHLFXELFNJZ-UHFFFAOYSA-N norepinephrine Natural products NCC(O)C1=CC=C(O)C(O)=C1 SFLSHLFXELFNJZ-UHFFFAOYSA-N 0.000 claims 1
- 229960005343 ondansetron Drugs 0.000 claims 1
- IENZQIKPVFGBNW-UHFFFAOYSA-N prazosin Chemical compound N=1C(N)=C2C=C(OC)C(OC)=CC2=NC=1N(CC1)CCN1C(=O)C1=CC=CO1 IENZQIKPVFGBNW-UHFFFAOYSA-N 0.000 claims 1
- 229960001289 prazosin Drugs 0.000 claims 1
- FTSUPYGMFAPCFZ-ZWNOBZJWSA-N quinpirole Chemical compound C([C@H]1CCCN([C@@H]1C1)CCC)C2=C1C=NN2 FTSUPYGMFAPCFZ-ZWNOBZJWSA-N 0.000 claims 1
- 230000004202 respiratory function Effects 0.000 claims 1
- 210000002345 respiratory system Anatomy 0.000 claims 1
- 239000000952 serotonin receptor agonist Substances 0.000 claims 1
- 208000011117 substance-related disease Diseases 0.000 claims 1
- 208000011580 syndromic disease Diseases 0.000 claims 1
- NQRYJNQNLNOLGT-UHFFFAOYSA-N tetrahydropyridine hydrochloride Natural products C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023010295A JP2023055798A (ja) | 2017-01-24 | 2023-01-26 | 呼吸機能を可能にするための、脊髄ネットワークへのアクセス |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762449993P | 2017-01-24 | 2017-01-24 | |
| US62/449,993 | 2017-01-24 | ||
| PCT/US2018/015098 WO2018140531A1 (en) | 2017-01-24 | 2018-01-24 | Accessing spinal network to enable respiratory function |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023010295A Division JP2023055798A (ja) | 2017-01-24 | 2023-01-26 | 呼吸機能を可能にするための、脊髄ネットワークへのアクセス |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2020518300A JP2020518300A (ja) | 2020-06-25 |
| JP2020518300A5 true JP2020518300A5 (https=) | 2021-03-11 |
Family
ID=62978687
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019539960A Pending JP2020518300A (ja) | 2017-01-24 | 2018-01-24 | 呼吸機能を可能にするための、脊髄ネットワークへのアクセス |
| JP2023010295A Pending JP2023055798A (ja) | 2017-01-24 | 2023-01-26 | 呼吸機能を可能にするための、脊髄ネットワークへのアクセス |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023010295A Pending JP2023055798A (ja) | 2017-01-24 | 2023-01-26 | 呼吸機能を可能にするための、脊髄ネットワークへのアクセス |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20190381313A1 (https=) |
| EP (2) | EP3573517B1 (https=) |
| JP (2) | JP2020518300A (https=) |
| CA (1) | CA3051401A1 (https=) |
| WO (1) | WO2018140531A1 (https=) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2823592C (en) | 2011-01-03 | 2021-11-23 | The Regents Of The University Of California | High density epidural stimulation for facilitation of locomotion, posture, voluntary movement, and recovery of autonomic, sexual, vasomotor, and cognitive function after neurological injury |
| JP2014533183A (ja) | 2011-11-11 | 2014-12-11 | ニューロイネイブリング テクノロジーズ インコーポレイテッド | 運動神経、感覚、自律、性的、血管運動および認知機能の回復を可能にするための非侵襲性神経調節装置 |
| US9415218B2 (en) | 2011-11-11 | 2016-08-16 | The Regents Of The University Of California | Transcutaneous spinal cord stimulation: noninvasive tool for activation of locomotor circuitry |
| AU2014228794B2 (en) | 2013-03-15 | 2019-04-18 | The Regents Of The University Of California | Multi-site transcutaneous electrical stimulation of the spinal cord for facilitation of locomotion |
| US10137299B2 (en) | 2013-09-27 | 2018-11-27 | The Regents Of The University Of California | Engaging the cervical spinal cord circuitry to re-enable volitional control of hand function in tetraplegic subjects |
| AU2015305237B2 (en) | 2014-08-21 | 2020-06-18 | The Regents Of The University Of California | Regulation of autonomic control of bladder voiding after a complete spinal cord injury |
| EP3185946B1 (en) | 2014-08-27 | 2019-10-09 | The Regents Of The University Of California | Multi-electrode array for spinal cord epidural stimulation |
| US11298533B2 (en) | 2015-08-26 | 2022-04-12 | The Regents Of The University Of California | Concerted use of noninvasive neuromodulation device with exoskeleton to enable voluntary movement and greater muscle activation when stepping in a chronically paralyzed subject |
| US11097122B2 (en) | 2015-11-04 | 2021-08-24 | The Regents Of The University Of California | Magnetic stimulation of the spinal cord to restore control of bladder and/or bowel |
| US11235154B2 (en) | 2017-02-17 | 2022-02-01 | The University Of British Columbia | Apparatus and methods for maintaining physiological functions |
| WO2018217791A1 (en) | 2017-05-23 | 2018-11-29 | The Regents Of The University Of California | Accessing spinal networks to address sexual dysfunction |
| DE20168827T1 (de) | 2017-06-30 | 2021-01-21 | Gtx Medical B.V. | System zur neuromodulierung |
| US12357828B2 (en) | 2017-12-05 | 2025-07-15 | Ecole Polytechnique Federale De Lausanne (Epfl) | System for planning and/or providing neuromodulation |
| ES3058711T3 (en) | 2017-12-05 | 2026-03-12 | Ecole Polytechnique Fed Lausanne Epfl | A system for planning and/or providing neuromodulation |
| EP3574952B1 (en) * | 2018-05-30 | 2020-11-25 | G-Therapeutics BV | An electrode array, a lead paddle and a neuromodulation system |
| US20210236837A1 (en) * | 2018-08-21 | 2021-08-05 | The Regents Of The University Of California | Transcutaneous electrical and/or magnetic spinal stimulation for bladder or bowel control in subjects without cns injury |
| JP2021534877A (ja) | 2018-08-23 | 2021-12-16 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニアThe Regents Of The University Of California | 神経根麻痺、馬尾症候群、及び上肢機能の回復のための非侵襲性脊髄刺激 |
| GB2578471B (en) * | 2018-10-29 | 2023-01-04 | Pneumowave Ltd | Condition detector |
| DE18205817T1 (de) | 2018-11-13 | 2020-12-24 | Gtx Medical B.V. | Sensor in bekleidung von gliedmassen oder schuhwerk |
| ES2911465T3 (es) | 2018-11-13 | 2022-05-19 | Onward Medical N V | Sistema de control para la reconstrucción y/o restauración del movimiento de un paciente |
| EP3695878B1 (en) | 2019-02-12 | 2023-04-19 | ONWARD Medical N.V. | A system for neuromodulation |
| US20220233848A1 (en) * | 2019-05-22 | 2022-07-28 | The Regents Of The University Of California | Transcutaneous electrical spinal cord neuromodulator and uses thereof |
| EP3827875B1 (en) | 2019-11-27 | 2023-07-05 | ONWARD Medical N.V. | Neuromodulation system |
| DE19211698T1 (de) | 2019-11-27 | 2021-09-02 | Onward Medical B.V. | Neuromodulation system |
| DE20160841T1 (de) * | 2020-03-04 | 2021-12-09 | Onward Medical B.V. | Ein neuromodulationssystem |
| CN111887866B (zh) * | 2020-06-11 | 2022-09-23 | 杭州师范大学 | 坐垫式实时多动症监测系统及方法 |
| CA3215317A1 (en) * | 2021-04-14 | 2022-10-20 | Daniel C. Lu | Spinal cord stimulation for conditioning respiratory muscles |
| GB202107670D0 (en) * | 2021-05-28 | 2021-07-14 | Univ Oxford Innovation Ltd | System and method for stimulating a nerve, automated resuscitation system |
| US20230053053A1 (en) * | 2021-08-11 | 2023-02-16 | Onward Medical N.V. | Neuromodulation system and method |
| CN116172541B (zh) * | 2022-07-13 | 2025-06-27 | 中国科学院心理研究所 | 一种脊髓静息态功能磁共振图像获取和分析方法 |
| US20260007889A1 (en) * | 2024-07-02 | 2026-01-08 | Spiro Medical, Inc. | Treating respiratory conditions using spinal cord stimulation |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5066272A (en) | 1990-06-29 | 1991-11-19 | The Johns Hopkins University | Magnetic nerve stimulator |
| US6086525A (en) | 1994-11-28 | 2000-07-11 | Neotonus, Inc. | Magnetic nerve stimulator for exciting peripheral nerves |
| US6500110B1 (en) | 1996-08-15 | 2002-12-31 | Neotonus, Inc. | Magnetic nerve stimulation seat device |
| US7146221B2 (en) | 2001-11-16 | 2006-12-05 | The Regents Of The University Of California | Flexible electrode array for artifical vision |
| US7840270B2 (en) * | 2003-07-23 | 2010-11-23 | Synapse Biomedical, Inc. | System and method for conditioning a diaphragm of a patient |
| WO2006007048A2 (en) * | 2004-05-04 | 2006-01-19 | The Cleveland Clinic Foundation | Methods of treating medical conditions by neuromodulation of the sympathetic nervous system |
| US7326649B2 (en) | 2004-05-14 | 2008-02-05 | University Of Southern California | Parylene-based flexible multi-electrode arrays for neuronal stimulation and recording and methods for manufacturing the same |
| CN1879906A (zh) | 2005-06-15 | 2006-12-20 | 郑云峰 | 中枢神经系统磁刺激装置及其使用方法 |
| US8676324B2 (en) | 2005-11-10 | 2014-03-18 | ElectroCore, LLC | Electrical and magnetic stimulators used to treat migraine/sinus headache, rhinitis, sinusitis, rhinosinusitis, and comorbid disorders |
| US8099146B1 (en) | 2006-03-23 | 2012-01-17 | Pacesetter, Inc. | System and method for calibrating a blood oxygen saturation sensor for use with an implantable medical device |
| US20090108969A1 (en) | 2007-10-31 | 2009-04-30 | Los Alamos National Security | Apparatus and method for transcranial and nerve magnetic stimulation |
| US8352036B2 (en) * | 2009-01-19 | 2013-01-08 | Anthony DiMarco | Respiratory muscle activation by spinal cord stimulation |
| US9174045B2 (en) | 2009-03-20 | 2015-11-03 | ElectroCore, LLC | Non-invasive electrical and magnetic nerve stimulators used to treat overactive bladder and urinary incontinence |
| US9403001B2 (en) | 2009-03-20 | 2016-08-02 | ElectroCore, LLC | Non-invasive magnetic or electrical nerve stimulation to treat gastroparesis, functional dyspepsia, and other functional gastrointestinal disorders |
| WO2012030743A1 (en) * | 2010-08-31 | 2012-03-08 | Boston Scientific Neuromodulation Corporation | Systems and methods for making and using enhanced electrodes for electrical stimulation systems |
| CA2823592C (en) | 2011-01-03 | 2021-11-23 | The Regents Of The University Of California | High density epidural stimulation for facilitation of locomotion, posture, voluntary movement, and recovery of autonomic, sexual, vasomotor, and cognitive function after neurological injury |
| JP2014508581A (ja) | 2011-01-21 | 2014-04-10 | カリフォルニア インスティテュート オブ テクノロジー | 脊髄刺激のためのパリレンベースのマイクロ電極アレイインプラント |
| EP2667934B1 (en) * | 2011-01-25 | 2020-05-27 | Apellis Holdings, LLC | Apparatus and methods for assisting breathing |
| KR20140013043A (ko) * | 2011-03-24 | 2014-02-04 | 캘리포니아 인스티튜트 오브 테크놀로지 | 신경자극기 |
| US9808164B2 (en) | 2011-09-30 | 2017-11-07 | Medtronic, Inc. | Evaluation of cardiac dyssynchrony based on chest wall motion and electrical cardiac activity |
| US8751004B2 (en) * | 2012-08-27 | 2014-06-10 | Anthony Fortunato DiMarco | Bipolar spinal cord stimulation to activate the expiratory muscles to restore cough |
| EP2890416A4 (en) * | 2012-08-31 | 2016-07-20 | Univ Florida | HAND AND SWALLOW CONTROL |
| MX2015007074A (es) * | 2012-12-05 | 2015-12-16 | Micron Devices Llc | Dispositivos y metodos para conectar dispositivos implantables a la energia inalambrica. |
| CN107405481A (zh) * | 2014-08-27 | 2017-11-28 | 加利福尼亚大学董事会 | 制造用于脊髓硬膜外刺激的多电极阵列的方法 |
| EP3191178B1 (en) * | 2014-09-11 | 2025-05-07 | Ridder, Dirk, De | System for nested neurostimulation |
| CA3030615A1 (en) * | 2015-07-13 | 2017-01-19 | The Regents Of The University Of California | Accessing spinal network to enable respiratory function |
| CN108136177A (zh) | 2015-08-06 | 2018-06-08 | 加利福尼亚大学董事会 | 用于对脊髓进行经皮电刺激的电极阵列及其用途 |
| WO2018009831A1 (en) * | 2016-07-08 | 2018-01-11 | Dimarco Anthony F | System and method for activating inspiratory and expiratory muscle function |
-
2018
- 2018-01-24 CA CA3051401A patent/CA3051401A1/en active Pending
- 2018-01-24 US US16/479,201 patent/US20190381313A1/en active Pending
- 2018-01-24 EP EP18744685.1A patent/EP3573517B1/en active Active
- 2018-01-24 JP JP2019539960A patent/JP2020518300A/ja active Pending
- 2018-01-24 EP EP23203890.1A patent/EP4299106B1/en active Active
- 2018-01-24 WO PCT/US2018/015098 patent/WO2018140531A1/en not_active Ceased
-
2023
- 2023-01-26 JP JP2023010295A patent/JP2023055798A/ja active Pending
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