JP2020518300A - 呼吸機能を可能にするための、脊髄ネットワークへのアクセス - Google Patents

呼吸機能を可能にするための、脊髄ネットワークへのアクセス Download PDF

Info

Publication number
JP2020518300A
JP2020518300A JP2019539960A JP2019539960A JP2020518300A JP 2020518300 A JP2020518300 A JP 2020518300A JP 2019539960 A JP2019539960 A JP 2019539960A JP 2019539960 A JP2019539960 A JP 2019539960A JP 2020518300 A JP2020518300 A JP 2020518300A
Authority
JP
Japan
Prior art keywords
stimulation
stimulator
spinal cord
epidural
frequency
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2019539960A
Other languages
English (en)
Japanese (ja)
Other versions
JP2020518300A5 (https=
Inventor
ダニエル・シー・ルー
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of California
University of California Los Angeles UCLA
Original Assignee
University of California San Diego UCSD
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of California San Diego UCSD filed Critical University of California San Diego UCSD
Publication of JP2020518300A publication Critical patent/JP2020518300A/ja
Publication of JP2020518300A5 publication Critical patent/JP2020518300A5/ja
Priority to JP2023010295A priority Critical patent/JP2023055798A/ja
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/08—Measuring devices for evaluating the respiratory organs
    • A61B5/0816—Measuring devices for examining respiratory frequency
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/48—Other medical applications
    • A61B5/4836—Diagnosis combined with treatment in closed-loop systems or methods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/48—Other medical applications
    • A61B5/4836—Diagnosis combined with treatment in closed-loop systems or methods
    • A61B5/4839—Diagnosis combined with treatment in closed-loop systems or methods combined with drug delivery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/0404—Electrodes for external use
    • A61N1/0408—Use-related aspects
    • A61N1/0456—Specially adapted for transcutaneous electrical nerve stimulation [TENS]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
    • A61N1/0502—Skin piercing electrodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
    • A61N1/0551—Spinal or peripheral nerve electrodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3601—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation of respiratory organs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/36014—External stimulators, e.g. with patch electrodes
    • A61N1/36017—External stimulators, e.g. with patch electrodes with leads or electrodes penetrating the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/36014—External stimulators, e.g. with patch electrodes
    • A61N1/3603—Control systems
    • A61N1/36031—Control systems using physiological parameters for adjustment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/36014—External stimulators, e.g. with patch electrodes
    • A61N1/3603—Control systems
    • A61N1/36034—Control systems specified by the stimulation parameters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/3606—Implantable neurostimulators for stimulating central or peripheral nerve system adapted for a particular treatment
    • A61N1/36062—Spinal stimulation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/3606—Implantable neurostimulators for stimulating central or peripheral nerve system adapted for a particular treatment
    • A61N1/3611—Respiration control
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/36128—Control systems
    • A61N1/36132—Control systems using patient feedback
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/36128—Control systems
    • A61N1/36135—Control systems using physiological parameters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/36128—Control systems
    • A61N1/36135—Control systems using physiological parameters
    • A61N1/36139—Control systems using physiological parameters with automatic adjustment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/36128—Control systems
    • A61N1/36146—Control systems specified by the stimulation parameters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/36128—Control systems
    • A61N1/36146—Control systems specified by the stimulation parameters
    • A61N1/3615—Intensity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/36128—Control systems
    • A61N1/36189—Control systems using modulation techniques
    • A61N1/36192—Amplitude modulation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/36128—Control systems
    • A61N1/36189—Control systems using modulation techniques
    • A61N1/36196—Frequency modulation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N2/00—Magnetotherapy
    • A61N2/004—Magnetotherapy specially adapted for a specific therapy
    • A61N2/006—Magnetotherapy specially adapted for a specific therapy for magnetic stimulation of nerve tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N2/00—Magnetotherapy
    • A61N2/02—Magnetotherapy using magnetic fields produced by coils, including single turn loops or electromagnets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
    • A61N1/0551—Spinal or peripheral nerve electrodes
    • A61N1/0553—Paddle shaped electrodes, e.g. for laminotomy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/36128—Control systems
    • A61N1/36146—Control systems specified by the stimulation parameters
    • A61N1/3615—Intensity
    • A61N1/36157—Current
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/36128—Control systems
    • A61N1/36146—Control systems specified by the stimulation parameters
    • A61N1/36167—Timing, e.g. stimulation onset
    • A61N1/36171—Frequency
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/36128—Control systems
    • A61N1/36146—Control systems specified by the stimulation parameters
    • A61N1/36167—Timing, e.g. stimulation onset
    • A61N1/36175—Pulse width or duty cycle

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Radiology & Medical Imaging (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biophysics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Physiology (AREA)
  • Pulmonology (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Medical Informatics (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Cardiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Electrotherapy Devices (AREA)
  • Magnetic Treatment Devices (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2019539960A 2017-01-24 2018-01-24 呼吸機能を可能にするための、脊髄ネットワークへのアクセス Pending JP2020518300A (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2023010295A JP2023055798A (ja) 2017-01-24 2023-01-26 呼吸機能を可能にするための、脊髄ネットワークへのアクセス

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762449993P 2017-01-24 2017-01-24
US62/449,993 2017-01-24
PCT/US2018/015098 WO2018140531A1 (en) 2017-01-24 2018-01-24 Accessing spinal network to enable respiratory function

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2023010295A Division JP2023055798A (ja) 2017-01-24 2023-01-26 呼吸機能を可能にするための、脊髄ネットワークへのアクセス

Publications (2)

Publication Number Publication Date
JP2020518300A true JP2020518300A (ja) 2020-06-25
JP2020518300A5 JP2020518300A5 (https=) 2021-03-11

Family

ID=62978687

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2019539960A Pending JP2020518300A (ja) 2017-01-24 2018-01-24 呼吸機能を可能にするための、脊髄ネットワークへのアクセス
JP2023010295A Pending JP2023055798A (ja) 2017-01-24 2023-01-26 呼吸機能を可能にするための、脊髄ネットワークへのアクセス

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2023010295A Pending JP2023055798A (ja) 2017-01-24 2023-01-26 呼吸機能を可能にするための、脊髄ネットワークへのアクセス

Country Status (5)

Country Link
US (1) US20190381313A1 (https=)
EP (2) EP3573517B1 (https=)
JP (2) JP2020518300A (https=)
CA (1) CA3051401A1 (https=)
WO (1) WO2018140531A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2024513975A (ja) * 2021-04-14 2024-03-27 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 呼吸筋をコンディショニングするための脊髄刺激療法

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2823592C (en) 2011-01-03 2021-11-23 The Regents Of The University Of California High density epidural stimulation for facilitation of locomotion, posture, voluntary movement, and recovery of autonomic, sexual, vasomotor, and cognitive function after neurological injury
JP2014533183A (ja) 2011-11-11 2014-12-11 ニューロイネイブリング テクノロジーズ インコーポレイテッド 運動神経、感覚、自律、性的、血管運動および認知機能の回復を可能にするための非侵襲性神経調節装置
US9415218B2 (en) 2011-11-11 2016-08-16 The Regents Of The University Of California Transcutaneous spinal cord stimulation: noninvasive tool for activation of locomotor circuitry
AU2014228794B2 (en) 2013-03-15 2019-04-18 The Regents Of The University Of California Multi-site transcutaneous electrical stimulation of the spinal cord for facilitation of locomotion
US10137299B2 (en) 2013-09-27 2018-11-27 The Regents Of The University Of California Engaging the cervical spinal cord circuitry to re-enable volitional control of hand function in tetraplegic subjects
AU2015305237B2 (en) 2014-08-21 2020-06-18 The Regents Of The University Of California Regulation of autonomic control of bladder voiding after a complete spinal cord injury
EP3185946B1 (en) 2014-08-27 2019-10-09 The Regents Of The University Of California Multi-electrode array for spinal cord epidural stimulation
US11298533B2 (en) 2015-08-26 2022-04-12 The Regents Of The University Of California Concerted use of noninvasive neuromodulation device with exoskeleton to enable voluntary movement and greater muscle activation when stepping in a chronically paralyzed subject
US11097122B2 (en) 2015-11-04 2021-08-24 The Regents Of The University Of California Magnetic stimulation of the spinal cord to restore control of bladder and/or bowel
US11235154B2 (en) 2017-02-17 2022-02-01 The University Of British Columbia Apparatus and methods for maintaining physiological functions
WO2018217791A1 (en) 2017-05-23 2018-11-29 The Regents Of The University Of California Accessing spinal networks to address sexual dysfunction
DE20168827T1 (de) 2017-06-30 2021-01-21 Gtx Medical B.V. System zur neuromodulierung
US12357828B2 (en) 2017-12-05 2025-07-15 Ecole Polytechnique Federale De Lausanne (Epfl) System for planning and/or providing neuromodulation
ES3058711T3 (en) 2017-12-05 2026-03-12 Ecole Polytechnique Fed Lausanne Epfl A system for planning and/or providing neuromodulation
EP3574952B1 (en) * 2018-05-30 2020-11-25 G-Therapeutics BV An electrode array, a lead paddle and a neuromodulation system
US20210236837A1 (en) * 2018-08-21 2021-08-05 The Regents Of The University Of California Transcutaneous electrical and/or magnetic spinal stimulation for bladder or bowel control in subjects without cns injury
JP2021534877A (ja) 2018-08-23 2021-12-16 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニアThe Regents Of The University Of California 神経根麻痺、馬尾症候群、及び上肢機能の回復のための非侵襲性脊髄刺激
GB2578471B (en) * 2018-10-29 2023-01-04 Pneumowave Ltd Condition detector
DE18205817T1 (de) 2018-11-13 2020-12-24 Gtx Medical B.V. Sensor in bekleidung von gliedmassen oder schuhwerk
ES2911465T3 (es) 2018-11-13 2022-05-19 Onward Medical N V Sistema de control para la reconstrucción y/o restauración del movimiento de un paciente
EP3695878B1 (en) 2019-02-12 2023-04-19 ONWARD Medical N.V. A system for neuromodulation
US20220233848A1 (en) * 2019-05-22 2022-07-28 The Regents Of The University Of California Transcutaneous electrical spinal cord neuromodulator and uses thereof
EP3827875B1 (en) 2019-11-27 2023-07-05 ONWARD Medical N.V. Neuromodulation system
DE19211698T1 (de) 2019-11-27 2021-09-02 Onward Medical B.V. Neuromodulation system
DE20160841T1 (de) * 2020-03-04 2021-12-09 Onward Medical B.V. Ein neuromodulationssystem
CN111887866B (zh) * 2020-06-11 2022-09-23 杭州师范大学 坐垫式实时多动症监测系统及方法
GB202107670D0 (en) * 2021-05-28 2021-07-14 Univ Oxford Innovation Ltd System and method for stimulating a nerve, automated resuscitation system
US20230053053A1 (en) * 2021-08-11 2023-02-16 Onward Medical N.V. Neuromodulation system and method
CN116172541B (zh) * 2022-07-13 2025-06-27 中国科学院心理研究所 一种脊髓静息态功能磁共振图像获取和分析方法
US20260007889A1 (en) * 2024-07-02 2026-01-08 Spiro Medical, Inc. Treating respiratory conditions using spinal cord stimulation

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014089299A2 (en) * 2012-12-05 2014-06-12 Perryman Laura Tyler Devices and methods for connecting implantable devices to wireless energy
JP2014514043A (ja) * 2011-03-24 2014-06-19 カリフォルニア インスティテュート オブ テクノロジー 神経刺激装置
WO2016033372A1 (en) * 2014-08-27 2016-03-03 The Regents Of The University Of California Methods of fabricating a multi-electrode array for spinal cord epidural stimulation
WO2017011410A1 (en) * 2015-07-13 2017-01-19 The Regents Of The University Of California Accessing spinal network to enable respiratory function

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5066272A (en) 1990-06-29 1991-11-19 The Johns Hopkins University Magnetic nerve stimulator
US6086525A (en) 1994-11-28 2000-07-11 Neotonus, Inc. Magnetic nerve stimulator for exciting peripheral nerves
US6500110B1 (en) 1996-08-15 2002-12-31 Neotonus, Inc. Magnetic nerve stimulation seat device
US7146221B2 (en) 2001-11-16 2006-12-05 The Regents Of The University Of California Flexible electrode array for artifical vision
US7840270B2 (en) * 2003-07-23 2010-11-23 Synapse Biomedical, Inc. System and method for conditioning a diaphragm of a patient
WO2006007048A2 (en) * 2004-05-04 2006-01-19 The Cleveland Clinic Foundation Methods of treating medical conditions by neuromodulation of the sympathetic nervous system
US7326649B2 (en) 2004-05-14 2008-02-05 University Of Southern California Parylene-based flexible multi-electrode arrays for neuronal stimulation and recording and methods for manufacturing the same
CN1879906A (zh) 2005-06-15 2006-12-20 郑云峰 中枢神经系统磁刺激装置及其使用方法
US8676324B2 (en) 2005-11-10 2014-03-18 ElectroCore, LLC Electrical and magnetic stimulators used to treat migraine/sinus headache, rhinitis, sinusitis, rhinosinusitis, and comorbid disorders
US8099146B1 (en) 2006-03-23 2012-01-17 Pacesetter, Inc. System and method for calibrating a blood oxygen saturation sensor for use with an implantable medical device
US20090108969A1 (en) 2007-10-31 2009-04-30 Los Alamos National Security Apparatus and method for transcranial and nerve magnetic stimulation
US8352036B2 (en) * 2009-01-19 2013-01-08 Anthony DiMarco Respiratory muscle activation by spinal cord stimulation
US9174045B2 (en) 2009-03-20 2015-11-03 ElectroCore, LLC Non-invasive electrical and magnetic nerve stimulators used to treat overactive bladder and urinary incontinence
US9403001B2 (en) 2009-03-20 2016-08-02 ElectroCore, LLC Non-invasive magnetic or electrical nerve stimulation to treat gastroparesis, functional dyspepsia, and other functional gastrointestinal disorders
WO2012030743A1 (en) * 2010-08-31 2012-03-08 Boston Scientific Neuromodulation Corporation Systems and methods for making and using enhanced electrodes for electrical stimulation systems
CA2823592C (en) 2011-01-03 2021-11-23 The Regents Of The University Of California High density epidural stimulation for facilitation of locomotion, posture, voluntary movement, and recovery of autonomic, sexual, vasomotor, and cognitive function after neurological injury
JP2014508581A (ja) 2011-01-21 2014-04-10 カリフォルニア インスティテュート オブ テクノロジー 脊髄刺激のためのパリレンベースのマイクロ電極アレイインプラント
EP2667934B1 (en) * 2011-01-25 2020-05-27 Apellis Holdings, LLC Apparatus and methods for assisting breathing
US9808164B2 (en) 2011-09-30 2017-11-07 Medtronic, Inc. Evaluation of cardiac dyssynchrony based on chest wall motion and electrical cardiac activity
US8751004B2 (en) * 2012-08-27 2014-06-10 Anthony Fortunato DiMarco Bipolar spinal cord stimulation to activate the expiratory muscles to restore cough
EP2890416A4 (en) * 2012-08-31 2016-07-20 Univ Florida HAND AND SWALLOW CONTROL
EP3191178B1 (en) * 2014-09-11 2025-05-07 Ridder, Dirk, De System for nested neurostimulation
CN108136177A (zh) 2015-08-06 2018-06-08 加利福尼亚大学董事会 用于对脊髓进行经皮电刺激的电极阵列及其用途
WO2018009831A1 (en) * 2016-07-08 2018-01-11 Dimarco Anthony F System and method for activating inspiratory and expiratory muscle function

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2014514043A (ja) * 2011-03-24 2014-06-19 カリフォルニア インスティテュート オブ テクノロジー 神経刺激装置
US20150231396A1 (en) * 2011-03-24 2015-08-20 California Institute Of Technology Neurostimulator
WO2014089299A2 (en) * 2012-12-05 2014-06-12 Perryman Laura Tyler Devices and methods for connecting implantable devices to wireless energy
JP2016506255A (ja) * 2012-12-05 2016-03-03 マイクロン デバイシーズ エルエルシー 植え込み装置を無線エネルギーに接続するための装置及び方法
WO2016033372A1 (en) * 2014-08-27 2016-03-03 The Regents Of The University Of California Methods of fabricating a multi-electrode array for spinal cord epidural stimulation
JP2017525509A (ja) * 2014-08-27 2017-09-07 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 脊髄硬膜外刺激のための多電極アレイの作製方法
WO2017011410A1 (en) * 2015-07-13 2017-01-19 The Regents Of The University Of California Accessing spinal network to enable respiratory function
JP2018524113A (ja) * 2015-07-13 2018-08-30 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 呼吸機能を可能にするために脊髄ネットワークにアクセスすること

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2024513975A (ja) * 2021-04-14 2024-03-27 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 呼吸筋をコンディショニングするための脊髄刺激療法

Also Published As

Publication number Publication date
EP3573517B1 (en) 2023-10-18
JP2023055798A (ja) 2023-04-18
EP4299106A2 (en) 2024-01-03
WO2018140531A1 (en) 2018-08-02
EP4299106B1 (en) 2025-09-03
EP3573517A4 (en) 2020-10-07
EP3573517A1 (en) 2019-12-04
EP4299106A3 (en) 2024-03-20
US20190381313A1 (en) 2019-12-19
CA3051401A1 (en) 2018-08-02

Similar Documents

Publication Publication Date Title
JP7520800B2 (ja) 呼吸機能を可能にするために脊髄ネットワークにアクセスすること
JP2023055798A (ja) 呼吸機能を可能にするための、脊髄ネットワークへのアクセス
Capogrosso et al. Configuration of electrical spinal cord stimulation through real-time processing of gait kinematics
Binks et al. High strength stimulation of the vagus nerve in awake humans: a lack of cardiorespiratory effects
US20130289675A1 (en) Materials and Approaches for Optical Stimulation of the Peripheral Nervous System
JP2013525029A (ja) 疼痛管理システム
WO2003072186A2 (en) Neurostimulation for affecting sleep disorders
WO2007007058A1 (en) Method and apparatus for regulating blood pressure
US8065014B2 (en) Method for promoting selective reinnervation of denervated tissue
US20240245909A1 (en) Method and system for altering body mass composition using galvanic vestibular stimulation
JP2019506960A (ja) 神経調整デバイス
Mickle et al. Closed-loop cervical epidural stimulation partially restores ipsilesional diaphragm EMG after acute C2 hemisection
AU2018297323B2 (en) Method and system for altering body mass composition using galvanic vestibular stimulation
Culp et al. Comparisons of the effects of acupuncture, electroacupuncture, and transcutaneous cranial electrical stimulation on the minimum alveolar concentration of isoflurane in dogs
JP2018523542A5 (https=)
JP2024513975A (ja) 呼吸筋をコンディショニングするための脊髄刺激療法
HK40018951A (en) Accessing spinal network to enable respiratory function
HK40018951B (en) Accessing spinal network to enable respiratory function
US20250135201A1 (en) Selective neurostimulation of peripheral nerves with reduced off-target activation
EP4635557A1 (en) System for inhibiting action potential conduction in a nerve
Kim et al. Superior laryngeal nerve brain stem evoked response in the cat
Mickle et al. Closed-Loop Cervical Epidural Stimulation Restores Ipsilesional Diaphragm Emg after Acute C2 Hemisection
Reier Plasticity and Activation of Spared Intraspinal Respiratory Circuits Following Spinal Cord Injury
Jaiswal Thoracic muscle respiratory load compensation in conscious animals and human respiratory perception after spinal cord injury
Hudson Strategies of motor unit recruitment in human inspiratory muscles

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20210125

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20210125

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20211122

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20211129

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20220207

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20220530

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20220926

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20230126

C60 Trial request (containing other claim documents, opposition documents)

Free format text: JAPANESE INTERMEDIATE CODE: C60

Effective date: 20230126

A911 Transfer to examiner for re-examination before appeal (zenchi)

Free format text: JAPANESE INTERMEDIATE CODE: A911

Effective date: 20230202

C21 Notice of transfer of a case for reconsideration by examiners before appeal proceedings

Free format text: JAPANESE INTERMEDIATE CODE: C21

Effective date: 20230213

A912 Re-examination (zenchi) completed and case transferred to appeal board

Free format text: JAPANESE INTERMEDIATE CODE: A912

Effective date: 20230224

C211 Notice of termination of reconsideration by examiners before appeal proceedings

Free format text: JAPANESE INTERMEDIATE CODE: C211

Effective date: 20230306