JP2020517597A - 軟骨形成を誘導するための方法 - Google Patents

軟骨形成を誘導するための方法 Download PDF

Info

Publication number
JP2020517597A
JP2020517597A JP2019555835A JP2019555835A JP2020517597A JP 2020517597 A JP2020517597 A JP 2020517597A JP 2019555835 A JP2019555835 A JP 2019555835A JP 2019555835 A JP2019555835 A JP 2019555835A JP 2020517597 A JP2020517597 A JP 2020517597A
Authority
JP
Japan
Prior art keywords
compound
pharmaceutically acceptable
administered
solvate
acceptable salt
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2019555835A
Other languages
English (en)
Japanese (ja)
Other versions
JP2020517597A5 (https=
Inventor
ジー． シュルツ，ピーター
ジー． シュルツ，ピーター
ケー． チャタジー，アルナブ
ケー． チャタジー，アルナブ
エム． ライト，ティモシー
エム． ライト，ティモシー
ウィスラー，ジョン
クリウシュニチェンコ，バディム
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Scripps Research Institute
Original Assignee
Scripps Research Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Scripps Research Institute filed Critical Scripps Research Institute
Publication of JP2020517597A publication Critical patent/JP2020517597A/ja
Publication of JP2020517597A5 publication Critical patent/JP2020517597A5/ja
Priority to JP2022195986A priority Critical patent/JP2023071181A/ja
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/18—Sulfonamides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/216—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials with other specific functional groups, e.g. aldehydes, ketones, phenols, quaternary phosphonium groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/452—Lubricants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/06—Flowable or injectable implant compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/06—Materials or treatment for tissue regeneration for cartilage reconstruction, e.g. meniscus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/24—Materials or treatment for tissue regeneration for joint reconstruction

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Molecular Biology (AREA)
  • Transplantation (AREA)
  • Dermatology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Biomedical Technology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP2019555835A 2017-04-24 2018-04-23 軟骨形成を誘導するための方法 Pending JP2020517597A (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2022195986A JP2023071181A (ja) 2017-04-24 2022-12-07 軟骨形成を誘導するための方法

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762489397P 2017-04-24 2017-04-24
US62/489,397 2017-04-24
PCT/US2018/028939 WO2018200411A1 (en) 2017-04-24 2018-04-23 Methods for inducing chondrogenesis

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2022195986A Division JP2023071181A (ja) 2017-04-24 2022-12-07 軟骨形成を誘導するための方法

Publications (2)

Publication Number Publication Date
JP2020517597A true JP2020517597A (ja) 2020-06-18
JP2020517597A5 JP2020517597A5 (https=) 2021-05-20

Family

ID=63919101

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2019555835A Pending JP2020517597A (ja) 2017-04-24 2018-04-23 軟骨形成を誘導するための方法
JP2022195986A Pending JP2023071181A (ja) 2017-04-24 2022-12-07 軟骨形成を誘導するための方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2022195986A Pending JP2023071181A (ja) 2017-04-24 2022-12-07 軟骨形成を誘導するための方法

Country Status (10)

Country Link
US (1) US20210361600A1 (https=)
EP (1) EP3615021A4 (https=)
JP (2) JP2020517597A (https=)
KR (1) KR20190137904A (https=)
CN (1) CN110809468A (https=)
AU (1) AU2018257769A1 (https=)
CA (1) CA3060518A1 (https=)
MA (1) MA48479A (https=)
RU (1) RU2019136884A (https=)
WO (1) WO2018200411A1 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12186307B2 (en) 2019-02-13 2025-01-07 Yale University Methods of treating epilepsy
FI129515B (en) 2020-11-06 2022-03-31 Salarusta Oy FOR USE IN THE PREVENTION AND / OR TREATMENT OF A DISEASE OR CONDITION RELATED TO THE DEGRADATION AND / OR DISTURBANCE OF THE DEGREE OF MONTOOSASE AND / OR INTEGRITY

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016519659A (ja) * 2013-03-15 2016-07-07 ザ カリフォルニア インスティテュート フォー バイオメディカル リサーチ 軟骨形成を誘導するための化合物及び方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9464065B2 (en) * 2011-03-24 2016-10-11 The Scripps Research Institute Compounds and methods for inducing chondrogenesis
DK3143026T3 (da) * 2014-05-13 2024-09-30 Novartis Ag Forbindelser og sammensætninger til induktion af chondrogenese

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016519659A (ja) * 2013-03-15 2016-07-07 ザ カリフォルニア インスティテュート フォー バイオメディカル リサーチ 軟骨形成を誘導するための化合物及び方法

Also Published As

Publication number Publication date
AU2018257769A1 (en) 2019-11-07
RU2019136884A (ru) 2021-05-25
US20210361600A1 (en) 2021-11-25
JP2023071181A (ja) 2023-05-22
RU2019136884A3 (https=) 2021-08-03
EP3615021A1 (en) 2020-03-04
CA3060518A1 (en) 2018-11-01
WO2018200411A1 (en) 2018-11-01
EP3615021A4 (en) 2020-12-30
MA48479A (fr) 2020-03-04
CN110809468A (zh) 2020-02-18
KR20190137904A (ko) 2019-12-11

Similar Documents

Publication Publication Date Title
US10882860B2 (en) Treatment of osteoarthritis
Ko et al. Sulforaphane–PLGA microspheres for the intra-articular treatment of osteoarthritis
CN113840598B (zh) 大麻素酸酯组合物及其用途
ES2900815T3 (es) Compuestos y métodos para inducir la condrogénesis
Mero et al. A hyaluronic acid–salmon calcitonin conjugate for the local treatment of osteoarthritis: Chondro-protective effect in a rabbit model of early OA
JPH11349480A (ja) カルプロフェンおよび誘導体を用いた哺乳類における関節軟骨または軟骨下骨変性の初期段階の処置および予防
BRPI0616324A2 (pt) formulaÇço de cÁpsula de pirfenidona e excipientes farmaceuticamente aceitÁveis
JP6431083B2 (ja) Ｆｇｆ−１８化合物の投与計画
JP2023071181A (ja) 軟骨形成を誘導するための方法
Chau et al. Hyaluronic acid instillation following arthroscopic anterior cruciate ligament reconstruction: a double-blinded, randomised controlled study
US20170266168A1 (en) Methods for preventing or treating osteoarthritis
Porter et al. Triamcinolone acetonide has minimal effect on short‐and long‐term metabolic activities of cartilage
Jansen et al. Development of partial-thickness articular cartilage injury in a rabbit model
CN114763347A (zh) 一类用于诱导间充质干细胞向软骨分化的化合物及其应用
Jazrawi et al. Intra-articular hyaluronic acid: potential treatment of younger patients with knee injury and/or post-traumatic arthritis
Liang et al. Varespladib-Based Lipid Nanoparticles as Highly Efficient Anti-Inflammatory Agents for Osteoarthritis Treatment
CA3004506C (en) Use of n-(5-(3-(7-(3- fluorophenyl)-3h-imidazo[4,5-c]pyridin-2-yl)-1h-indazol-5-yl)pyridin-3-yl)-3-methylbutanamide in the treatment of osteoarthritis
Wiegant Knee joint distraction. Intrinsic cartilage repair and sustained clinical benefit
Lei et al. Intra-Articular Purified Exosome Product and Hyaluronan Attenuate Osteoarthritis Progression in a Minimally Invasive Turkey Model
Vogrin et al. T2 mapping evaluation of changes in cartilage matrix after PRP and HA injection therapy in knee osteoarthritis: a prospective, randomized, double blind, placebo controlled study
HK40111798A (zh) 大麻素酸酯组合物及其用途
WO2024088712A1 (en) Mglur5 receptor antagonists for use in prevention and/or treatment of bone marrow lesions (bml) and/or osteoporosis, cartilage loss, osteosclerosis, osteitis in a mammal
TW202521115A (zh) 治療腱鞘巨細胞瘤之方法
HK40063789B (zh) 大麻素酸酯组合物及其用途
HK40045419A (en) Methods and compositions for killing senescent cells and for treating senescence-associated diseases and disorders

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20200204

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20210409

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20210412

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20211217

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20211220

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20220309

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20220615

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20220808