JP2020517304A5 - - Google Patents
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- Publication number
- JP2020517304A5 JP2020517304A5 JP2020507747A JP2020507747A JP2020517304A5 JP 2020517304 A5 JP2020517304 A5 JP 2020517304A5 JP 2020507747 A JP2020507747 A JP 2020507747A JP 2020507747 A JP2020507747 A JP 2020507747A JP 2020517304 A5 JP2020517304 A5 JP 2020517304A5
- Authority
- JP
- Japan
- Prior art keywords
- target
- dna
- fetal
- read
- probe
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 claims description 28
- 239000000523 sample Substances 0.000 claims description 17
- 230000001605 fetal effect Effects 0.000 claims description 13
- 239000012472 biological sample Substances 0.000 claims description 7
- 230000008774 maternal effect Effects 0.000 claims description 7
- 235000014676 Phragmites communis Nutrition 0.000 claims description 6
- 238000012163 sequencing technique Methods 0.000 claims description 6
- 239000003298 DNA probe Substances 0.000 claims description 2
- 108020004518 RNA Probes Proteins 0.000 claims description 2
- 239000003391 RNA probe Substances 0.000 claims description 2
- 238000012350 deep sequencing Methods 0.000 claims description 2
- 238000009396 hybridization Methods 0.000 claims description 2
- 238000013507 mapping Methods 0.000 claims description 2
- 210000003754 fetus Anatomy 0.000 claims 1
- 238000010606 normalization Methods 0.000 claims 1
- 208000036878 aneuploidy Diseases 0.000 description 4
- 231100001075 aneuploidy Toxicity 0.000 description 4
- 244000273256 Phragmites communis Species 0.000 description 2
- 108020004707 nucleic acids Proteins 0.000 description 2
- 150000007523 nucleic acids Chemical class 0.000 description 2
- 102000039446 nucleic acids Human genes 0.000 description 2
- 230000002759 chromosomal effect Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 238000007479 molecular analysis Methods 0.000 description 1
- 230000003252 repetitive effect Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP17166836 | 2017-04-18 | ||
| EP17166836.1 | 2017-04-18 | ||
| PCT/EP2018/059889 WO2018192967A1 (en) | 2017-04-18 | 2018-04-18 | Use of off-target sequences for dna analysis |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020517304A JP2020517304A (ja) | 2020-06-18 |
| JP2020517304A5 true JP2020517304A5 (enExample) | 2021-05-27 |
| JP7170711B2 JP7170711B2 (ja) | 2022-11-14 |
Family
ID=58549069
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020507747A Active JP7170711B2 (ja) | 2017-04-18 | 2018-04-18 | Ｄｎａ分析のためのオフターゲット配列の使用 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20200048715A1 (enExample) |
| EP (2) | EP3988672B1 (enExample) |
| JP (1) | JP7170711B2 (enExample) |
| CN (1) | CN110475874A (enExample) |
| CA (1) | CA3058845A1 (enExample) |
| WO (1) | WO2018192967A1 (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP4305200A1 (en) * | 2021-03-09 | 2024-01-17 | Guardant Health, Inc. | Detecting the presence of a tumor based on off-target polynucleotide sequencing data |
| CN114334007B (zh) * | 2022-01-20 | 2024-10-18 | 腾讯科技（深圳）有限公司 | 基因脱靶预测模型训练方法、预测方法、装置及电子设备 |
| CN119207553B (zh) * | 2024-10-08 | 2025-10-10 | 上海唯可生物科技有限公司 | 一种基于靶向富集测序评估基因编辑脱靶风险的方法 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP4074838A1 (en) * | 2010-01-19 | 2022-10-19 | Verinata Health, Inc. | Novel protocol for preparing sequencing libraries |
| US11322224B2 (en) * | 2010-05-18 | 2022-05-03 | Natera, Inc. | Methods for non-invasive prenatal ploidy calling |
| ES2651612T3 (es) * | 2011-10-18 | 2018-01-29 | Multiplicom Nv | Diagnóstico de aneuploidía cromosómica fetal |
| AU2013245272B2 (en) * | 2012-04-06 | 2018-04-05 | The Chinese University Of Hong Kong | Noninvasive prenatal diagnosis of fetal trisomy by allelic ratio analysis using targeted massively parallel sequencing |
| EP3409791B1 (en) * | 2013-03-15 | 2021-06-30 | Verinata Health, Inc. | Generating cell-free dna libraries directly from blood |
| EP4567682A3 (en) | 2013-08-30 | 2025-09-03 | Personalis, Inc. | Methods for genomic analysis |
| KR101721480B1 (ko) * | 2016-06-02 | 2017-03-30 | 주식회사 랩 지노믹스 | 염색체 이상 검사 방법 및 시스템 |
-
2018
- 2018-04-18 EP EP21208315.8A patent/EP3988672B1/en active Active
- 2018-04-18 US US16/606,076 patent/US20200048715A1/en not_active Abandoned
- 2018-04-18 CA CA3058845A patent/CA3058845A1/en active Pending
- 2018-04-18 JP JP2020507747A patent/JP7170711B2/ja active Active
- 2018-04-18 EP EP18717082.4A patent/EP3612644B1/en active Active
- 2018-04-18 WO PCT/EP2018/059889 patent/WO2018192967A1/en not_active Ceased
- 2018-04-18 CN CN201880018765.4A patent/CN110475874A/zh active Pending
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