JP2020517272A5 - - Google Patents
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- Publication number
- JP2020517272A5 JP2020517272A5 JP2019557431A JP2019557431A JP2020517272A5 JP 2020517272 A5 JP2020517272 A5 JP 2020517272A5 JP 2019557431 A JP2019557431 A JP 2019557431A JP 2019557431 A JP2019557431 A JP 2019557431A JP 2020517272 A5 JP2020517272 A5 JP 2020517272A5
- Authority
- JP
- Japan
- Prior art keywords
- recombinant phagemid
- genome
- particle
- particles
- expression cassette
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000002245 particle Substances 0.000 claims 48
- 230000014509 gene expression Effects 0.000 claims 21
- 108700019146 Transgenes Proteins 0.000 claims 18
- 102000004127 Cytokines Human genes 0.000 claims 17
- 108090000695 Cytokines Proteins 0.000 claims 17
- 150000007523 nucleic acids Chemical group 0.000 claims 15
- 238000004806 packaging method and process Methods 0.000 claims 11
- 241001515965 unidentified phage Species 0.000 claims 10
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 9
- 210000004881 tumor cell Anatomy 0.000 claims 9
- 108020004414 DNA Proteins 0.000 claims 8
- 102000053602 DNA Human genes 0.000 claims 8
- 108020004682 Single-Stranded DNA Proteins 0.000 claims 8
- 108020004707 nucleic acids Proteins 0.000 claims 7
- 102000039446 nucleic acids Human genes 0.000 claims 7
- 239000008194 pharmaceutical composition Substances 0.000 claims 7
- 108060008682 Tumor Necrosis Factor Proteins 0.000 claims 6
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 claims 6
- 238000000034 method Methods 0.000 claims 6
- 230000010076 replication Effects 0.000 claims 6
- 108090000623 proteins and genes Proteins 0.000 claims 5
- 108090000172 Interleukin-15 Proteins 0.000 claims 4
- 108010076504 Protein Sorting Signals Proteins 0.000 claims 4
- 101710172711 Structural protein Proteins 0.000 claims 4
- 210000000234 capsid Anatomy 0.000 claims 4
- 210000004027 cell Anatomy 0.000 claims 4
- 238000011282 treatment Methods 0.000 claims 4
- 206010028980 Neoplasm Diseases 0.000 claims 3
- 108020005091 Replication Origin Proteins 0.000 claims 3
- MZVQCMJNVPIDEA-UHFFFAOYSA-N [CH2]CN(CC)CC Chemical group [CH2]CN(CC)CC MZVQCMJNVPIDEA-UHFFFAOYSA-N 0.000 claims 3
- 239000000126 substance Substances 0.000 claims 3
- 101710192393 Attachment protein G3P Proteins 0.000 claims 2
- 101710169873 Capsid protein G8P Proteins 0.000 claims 2
- 101100369992 Homo sapiens TNFSF10 gene Proteins 0.000 claims 2
- 102100037850 Interferon gamma Human genes 0.000 claims 2
- 108010074328 Interferon-gamma Proteins 0.000 claims 2
- 108010065805 Interleukin-12 Proteins 0.000 claims 2
- 108010002350 Interleukin-2 Proteins 0.000 claims 2
- 108090000978 Interleukin-4 Proteins 0.000 claims 2
- 101710125418 Major capsid protein Proteins 0.000 claims 2
- 101710156564 Major tail protein Gp23 Proteins 0.000 claims 2
- 229920002873 Polyethylenimine Polymers 0.000 claims 2
- 108700012411 TNFSF10 Proteins 0.000 claims 2
- 241000700605 Viruses Species 0.000 claims 2
- 229920006317 cationic polymer Polymers 0.000 claims 2
- 238000012258 culturing Methods 0.000 claims 2
- 239000012634 fragment Substances 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 229920000642 polymer Polymers 0.000 claims 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 230000028327 secretion Effects 0.000 claims 2
- 208000003174 Brain Neoplasms Diseases 0.000 claims 1
- 229920001661 Chitosan Polymers 0.000 claims 1
- KDXKERNSBIXSRK-RXMQYKEDSA-N D-lysine Chemical compound NCCCC[C@@H](N)C(O)=O KDXKERNSBIXSRK-RXMQYKEDSA-N 0.000 claims 1
- 241000702421 Dependoparvovirus Species 0.000 claims 1
- 229920002491 Diethylaminoethyl-dextran Polymers 0.000 claims 1
- 241000255925 Diptera Species 0.000 claims 1
- 208000032612 Glial tumor Diseases 0.000 claims 1
- 206010018338 Glioma Diseases 0.000 claims 1
- 241000713666 Lentivirus Species 0.000 claims 1
- 208000000172 Medulloblastoma Diseases 0.000 claims 1
- 101710193132 Pre-hexon-linking protein VIII Proteins 0.000 claims 1
- 108091081062 Repeated sequence (DNA) Proteins 0.000 claims 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims 1
- 150000001413 amino acids Chemical group 0.000 claims 1
- 230000006023 anti-tumor response Effects 0.000 claims 1
- 230000006907 apoptotic process Effects 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 125000002091 cationic group Chemical group 0.000 claims 1
- 230000001413 cellular effect Effects 0.000 claims 1
- 238000003745 diagnosis Methods 0.000 claims 1
- 208000028919 diffuse intrinsic pontine glioma Diseases 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 238000001125 extrusion Methods 0.000 claims 1
- 230000006698 induction Effects 0.000 claims 1
- 230000010354 integration Effects 0.000 claims 1
- 239000003446 ligand Substances 0.000 claims 1
- 229920001184 polypeptide Polymers 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1706451.0 | 2017-04-24 | ||
| GBGB1706451.0A GB201706451D0 (en) | 2017-04-24 | 2017-04-24 | Cancer treatment |
| PCT/GB2018/051070 WO2018197859A1 (en) | 2017-04-24 | 2018-04-24 | Cancer treatment |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020517272A JP2020517272A (ja) | 2020-06-18 |
| JP2020517272A5 true JP2020517272A5 (enExample) | 2021-07-29 |
| JP7671483B2 JP7671483B2 (ja) | 2025-05-02 |
Family
ID=58795775
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019557431A Active JP7671483B2 (ja) | 2017-04-24 | 2018-04-24 | 癌の治療 |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US11820792B2 (enExample) |
| EP (1) | EP3615562A1 (enExample) |
| JP (1) | JP7671483B2 (enExample) |
| CN (1) | CN110546253A (enExample) |
| CA (1) | CA3061422A1 (enExample) |
| GB (1) | GB201706451D0 (enExample) |
| WO (1) | WO2018197859A1 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101697473B1 (ko) | 2014-11-26 | 2017-01-18 | 주식회사 녹십자랩셀 | T 세포를 이용한 자연살해세포의 배양방법 |
| GB201519303D0 (en) | 2015-11-02 | 2015-12-16 | Imp Innovations Ltd | Phagemid vector |
| GB201706451D0 (en) | 2017-04-24 | 2017-06-07 | Imp Innovations Ltd | Cancer treatment |
| CN110662834B (zh) | 2017-05-26 | 2023-09-12 | Gc细胞治疗 | 使用转化的t细胞培养自然杀伤细胞的方法 |
| EP3892721A4 (en) * | 2018-11-14 | 2022-08-31 | GC Cell Corporation | METHOD FOR CULTIVATING NATURAL KILLER CELLS DERIVED FROM UMBILICAL CORD BLOOD USING TRANSFORMED T LYMPHOCYTES |
| WO2022272297A1 (en) * | 2021-06-25 | 2022-12-29 | Oxford Biomedica Solutions Llc | Adeno-associated virus packaging systems |
| WO2024149989A1 (en) * | 2023-01-10 | 2024-07-18 | Imperial College Innovations Limited | Phage vector |
| CN116790520A (zh) * | 2023-06-20 | 2023-09-22 | 扬州大学 | 一种可识别肿瘤表面的cea蛋白与表达3c蛋白的短链噬菌粒及其构建与应用 |
| CN116790521A (zh) * | 2023-06-20 | 2023-09-22 | 扬州大学 | 一种可识别肿瘤表面的cea蛋白与表达egfp蛋白的重组噬菌体及其构建与应用 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1992009690A2 (en) * | 1990-12-03 | 1992-06-11 | Genentech, Inc. | Enrichment method for variant proteins with altered binding properties |
| EP1660636A4 (en) | 2003-08-26 | 2009-07-01 | Univ Texas | VACCINES AGAINST CANCER |
| EP1960526A4 (en) | 2005-12-07 | 2009-07-15 | Los Alamos Nat Security Llc | PLASMIDES AND PACKAGING CELL LINES FOR USE IN A PHAG DISPLAY |
| EP2009990B1 (en) | 2006-04-07 | 2016-09-21 | The Board of Regents of The University of Texas System | Methods and compositions related to adenoassociated virus-phage particles |
| JP2013527753A (ja) * | 2010-03-23 | 2013-07-04 | イントレキソン コーポレーション | 治療タンパク質を条件的に発現するベクター、該ベクターを含む宿主細胞およびそれらの使用 |
| GB201308742D0 (en) | 2013-05-15 | 2013-06-26 | Imp Innovations | Bacteriophage |
| GB201308745D0 (en) | 2013-05-15 | 2013-06-26 | Imp Innovations | Bacteriophage |
| WO2015105806A2 (en) * | 2014-01-07 | 2015-07-16 | Oklahoma Medical Research Foundation | Antibodies against glioma biomarkers |
| AU2016334401A1 (en) * | 2015-10-10 | 2018-04-26 | Intrexon Corporation | Improved therapeutic control of proteolytically sensitive, destabilized forms of interleukin-12 |
| GB201519303D0 (en) | 2015-11-02 | 2015-12-16 | Imp Innovations Ltd | Phagemid vector |
| GB201706451D0 (en) | 2017-04-24 | 2017-06-07 | Imp Innovations Ltd | Cancer treatment |
-
2017
- 2017-04-24 GB GBGB1706451.0A patent/GB201706451D0/en not_active Ceased
-
2018
- 2018-04-24 CA CA3061422A patent/CA3061422A1/en active Pending
- 2018-04-24 CN CN201880025164.6A patent/CN110546253A/zh active Pending
- 2018-04-24 US US16/607,653 patent/US11820792B2/en active Active
- 2018-04-24 WO PCT/GB2018/051070 patent/WO2018197859A1/en not_active Ceased
- 2018-04-24 EP EP18722706.1A patent/EP3615562A1/en active Pending
- 2018-04-24 JP JP2019557431A patent/JP7671483B2/ja active Active
-
2023
- 2023-09-22 US US18/472,764 patent/US20240101628A1/en active Pending
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