JP2020516322A5 - - Google Patents
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- Publication number
- JP2020516322A5 JP2020516322A5 JP2020506311A JP2020506311A JP2020516322A5 JP 2020516322 A5 JP2020516322 A5 JP 2020516322A5 JP 2020506311 A JP2020506311 A JP 2020506311A JP 2020506311 A JP2020506311 A JP 2020506311A JP 2020516322 A5 JP2020516322 A5 JP 2020516322A5
- Authority
- JP
- Japan
- Prior art keywords
- htcbs
- nhs ester
- pegylation
- batch
- retention time
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 102220612388 Mitogen-activated protein kinase kinase kinase 1_C15S_mutation Human genes 0.000 claims 18
- 238000000034 method Methods 0.000 claims 17
- 150000002148 esters Chemical class 0.000 claims 16
- 230000006320 pegylation Effects 0.000 claims 15
- 230000014759 maintenance of location Effects 0.000 claims 12
- 235000001014 amino acid Nutrition 0.000 claims 4
- 150000001413 amino acids Chemical group 0.000 claims 4
- 238000004458 analytical method Methods 0.000 claims 4
- 102100034976 Cystathionine beta-synthase Human genes 0.000 claims 2
- 108010073644 Cystathionine beta-synthase Proteins 0.000 claims 2
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 claims 2
- 238000004587 chromatography analysis Methods 0.000 claims 2
- 230000001268 conjugating effect Effects 0.000 claims 2
- 235000018417 cysteine Nutrition 0.000 claims 2
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims 2
- 230000035772 mutation Effects 0.000 claims 2
- 235000018102 proteins Nutrition 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 238000005251 capillar electrophoresis Methods 0.000 claims 1
- 230000007717 exclusion Effects 0.000 claims 1
- 238000004811 liquid chromatography Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762486246P | 2017-04-17 | 2017-04-17 | |
| US62/486,246 | 2017-04-17 | ||
| PCT/US2018/027854 WO2018195006A1 (en) | 2017-04-17 | 2018-04-17 | Optimization of enzyme replacement therapy for treatment of homocystinuria |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020516322A JP2020516322A (ja) | 2020-06-11 |
| JP2020516322A5 true JP2020516322A5 (https=) | 2021-05-27 |
| JP7146897B2 JP7146897B2 (ja) | 2022-10-04 |
Family
ID=63856394
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020506311A Active JP7146897B2 (ja) | 2017-04-17 | 2018-04-17 | ホモシスチン尿症の治療のための酵素補充療法の最適化 |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US11324811B2 (https=) |
| EP (1) | EP3612214A4 (https=) |
| JP (1) | JP7146897B2 (https=) |
| CN (2) | CN118064414A (https=) |
| AU (1) | AU2018254410B2 (https=) |
| CA (1) | CA3059592A1 (https=) |
| IL (1) | IL269544B2 (https=) |
| MX (1) | MX2019012347A (https=) |
| WO (1) | WO2018195006A1 (https=) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9675678B2 (en) | 2013-01-29 | 2017-06-13 | The Regents Of The University Of Colorado, A Body Corporate | Compositions and methods for treatment of homocystinuria |
| FI3998067T3 (fi) * | 2015-11-09 | 2024-10-31 | Univ Colorado Regents | Koostumukset ja menetelmät homokystinurian hoitoon |
| IL269544B2 (en) | 2017-04-17 | 2025-01-01 | Univ Colorado Regents | Streamlining enzyme replacement therapy for the treatment of high homocysteine |
| ES3058596T3 (en) | 2019-06-26 | 2026-03-11 | Travere Therapeutics Switzerland Gmbh | Pegylated cystathionine beta synthase for enzyme therapy for treatment of homocystinuria |
| CA3152379A1 (en) * | 2019-09-03 | 2021-03-11 | Travere Therapeutics Switzerland Gmbh | Cystathionine beta-synthase enzyme therapy for treatment of elevated homocysteine levels |
| CN114965761B (zh) * | 2022-05-17 | 2024-07-02 | 深圳赛保尔生物药业有限公司 | 聚乙二醇化蛋白药物中n-羟基琥珀酰亚胺的检测方法 |
| WO2025193499A1 (en) * | 2024-03-12 | 2025-09-18 | The Regents Of The University Of Colorado, A Body Corporate | Compositions and methods to potentiate enzyme therapies for treating homocystinuria and homocysteine remethylation disorders |
Family Cites Families (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5576559A (en) | 1978-12-01 | 1980-06-09 | Chiyou Lsi Gijutsu Kenkyu Kumiai | Electron beam fine adjusting device |
| JPS57209206A (en) | 1981-06-08 | 1982-12-22 | Kanebo Ltd | Skin type pack agent |
| US5656425A (en) | 1993-08-17 | 1997-08-12 | Regents Of The University Of Colorado | Screening for mutations by expressing cDNA segments |
| US5523225A (en) | 1993-09-13 | 1996-06-04 | Regents Of The University Of Colorado | DNA sequence encoding human cystathionine β-synthase |
| US5919455A (en) | 1993-10-27 | 1999-07-06 | Enzon, Inc. | Non-antigenic branched polymer conjugates |
| US5643575A (en) | 1993-10-27 | 1997-07-01 | Enzon, Inc. | Non-antigenic branched polymer conjugates |
| US5730990A (en) | 1994-06-24 | 1998-03-24 | Enzon, Inc. | Non-antigenic amine derived polymers and polymer conjugates |
| US5635375A (en) | 1995-01-09 | 1997-06-03 | Regents Of The University Of Colorado | Method of increasing the yield and heme saturation of cystathione β-synthase |
| CA2217696A1 (en) | 1995-04-25 | 1996-10-31 | Oridigm Corporation | S-adenosyl methionine regulation of metabolic pathways and its use in diagnosis and therapy |
| US5705151A (en) | 1995-05-18 | 1998-01-06 | National Jewish Center For Immunology & Respiratory Medicine | Gene therapy for T cell regulation |
| US6153655A (en) | 1998-04-17 | 2000-11-28 | Enzon, Inc. | Terminally-branched polymeric linkers and polymeric conjugates containing the same |
| EE05214B1 (et) * | 1998-04-28 | 2009-10-15 | Applied Research Systems ARS Holding N.V. | Polool-IFN- β konjugaat, selle valmistamismeetod ja farmatseutiline kompositsioon |
| US6174696B1 (en) | 1999-11-12 | 2001-01-16 | Genzyme Corporation | Method for the determination of homocysteine |
| WO2001002600A2 (en) | 1999-07-06 | 2001-01-11 | General Atomics | Detection of analytes using attenuated enzymes |
| US20030091543A1 (en) | 2001-10-26 | 2003-05-15 | Klein Matthew B. | Therapeutic cell preparation grafts and methods of use thereof |
| AU2003251550A1 (en) | 2002-06-17 | 2003-12-31 | The Regents Of The University Of Colorado | HUMAN CYSTATHIONINE Beta-SYNTHASE VARIANTS AND METHODS OF PRODU CTION THEREOF |
| GB0216001D0 (en) | 2002-07-10 | 2002-08-21 | Nat Blood Authority | Process and composition |
| EP1396537A1 (en) | 2002-09-04 | 2004-03-10 | Avidis SA | Treatment of elevated plasma homocysteine |
| CN1863551A (zh) | 2003-07-31 | 2006-11-15 | 抗癌公司 | 用于提高在体内的效力的PLP和PEG－rMETase的用途 |
| CN1552905A (zh) | 2003-12-18 | 2004-12-08 | 中国农业科学院茶叶研究所 | 一类茶树胱硫醚-γ-合成酶特异表达序列标签及其生物芯片 |
| US8500720B2 (en) | 2005-05-09 | 2013-08-06 | Medtronic, Inc | Method and apparatus for treatment of cardiac disorders |
| US20070010492A1 (en) | 2005-07-11 | 2007-01-11 | Generale Robert J | Composition and method for reducing homocysteine caused by drugs containing methyl compounds |
| EP1878739A1 (en) | 2006-07-14 | 2008-01-16 | LEK Pharmaceuticals D.D. | One step IMAC (MCAC) purification of proteins |
| JP5074146B2 (ja) | 2007-03-30 | 2012-11-14 | オリンパス株式会社 | カプセル型医療装置 |
| CN101322840A (zh) | 2008-05-28 | 2008-12-17 | 中国人民解放军军事医学科学院卫生学环境医学研究所 | 一种人胱硫醚β-合成酶重组蛋白及应用 |
| JP2011084559A (ja) * | 2009-09-16 | 2011-04-28 | Institute Of Physical & Chemical Research | 改変融合タンパク質 |
| CA2788689C (en) | 2010-02-04 | 2019-07-02 | The Board Of Regents Of The University Of Texas System | Engineered enzymes with methionine-gamma-lyase enzymes and pharmacological preparations thereof |
| EA201370008A1 (ru) | 2010-07-01 | 2013-06-28 | Айсис Инновэйшн Лимитид | Лечение когнитивных нарушений |
| US9034318B2 (en) | 2011-08-30 | 2015-05-19 | The Regents Of The University Of Colorado, A Body Corporate | Chemically modified cystathionine beta-synthase enzyme for treatment of homocystinuria |
| US9243239B2 (en) | 2012-03-26 | 2016-01-26 | The Regents Of The University Of Colorado, A Body Corporate | Purification of cystathionine beta-synthase |
| US9675678B2 (en) | 2013-01-29 | 2017-06-13 | The Regents Of The University Of Colorado, A Body Corporate | Compositions and methods for treatment of homocystinuria |
| WO2015033279A1 (en) | 2013-09-04 | 2015-03-12 | Mahesh Kandula | Compositions and methods for the treatment of homocystinuria |
| US11123436B2 (en) * | 2015-07-24 | 2021-09-21 | Hanmi Pharm. Co., Ltd. | Method of preparing physiologically active polypeptide conjugate |
| FI3998067T3 (fi) | 2015-11-09 | 2024-10-31 | Univ Colorado Regents | Koostumukset ja menetelmät homokystinurian hoitoon |
| IL269544B2 (en) | 2017-04-17 | 2025-01-01 | Univ Colorado Regents | Streamlining enzyme replacement therapy for the treatment of high homocysteine |
| ES3058596T3 (en) | 2019-06-26 | 2026-03-11 | Travere Therapeutics Switzerland Gmbh | Pegylated cystathionine beta synthase for enzyme therapy for treatment of homocystinuria |
| CA3152379A1 (en) | 2019-09-03 | 2021-03-11 | Travere Therapeutics Switzerland Gmbh | Cystathionine beta-synthase enzyme therapy for treatment of elevated homocysteine levels |
-
2018
- 2018-04-17 IL IL269544A patent/IL269544B2/en unknown
- 2018-04-17 JP JP2020506311A patent/JP7146897B2/ja active Active
- 2018-04-17 CN CN202410188237.0A patent/CN118064414A/zh active Pending
- 2018-04-17 MX MX2019012347A patent/MX2019012347A/es unknown
- 2018-04-17 EP EP18787619.8A patent/EP3612214A4/en active Pending
- 2018-04-17 WO PCT/US2018/027854 patent/WO2018195006A1/en not_active Ceased
- 2018-04-17 CN CN201880025544.XA patent/CN110753556A/zh active Pending
- 2018-04-17 US US16/605,918 patent/US11324811B2/en active Active
- 2018-04-17 CA CA3059592A patent/CA3059592A1/en active Pending
- 2018-04-17 AU AU2018254410A patent/AU2018254410B2/en active Active
-
2022
- 2022-04-05 US US17/713,891 patent/US12042529B2/en active Active
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