JP2020516258A5 - - Google Patents
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- JP2020516258A5 JP2020516258A5 JP2019555112A JP2019555112A JP2020516258A5 JP 2020516258 A5 JP2020516258 A5 JP 2020516258A5 JP 2019555112 A JP2019555112 A JP 2019555112A JP 2019555112 A JP2019555112 A JP 2019555112A JP 2020516258 A5 JP2020516258 A5 JP 2020516258A5
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- JP
- Japan
- Prior art keywords
- compound
- target
- cells
- iii
- combination
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 150000001875 compounds Chemical class 0.000 claims 28
- 210000004027 cell Anatomy 0.000 claims 14
- 238000010362 genome editing Methods 0.000 claims 9
- 108020004414 DNA Proteins 0.000 claims 7
- 239000003112 inhibitor Substances 0.000 claims 4
- 102000053602 DNA Human genes 0.000 claims 3
- 102000001253 Protein Kinase Human genes 0.000 claims 3
- 230000003197 catalytic effect Effects 0.000 claims 3
- 230000035772 mutation Effects 0.000 claims 3
- 108060006633 protein kinase Proteins 0.000 claims 3
- 108091033409 CRISPR Proteins 0.000 claims 2
- 238000010354 CRISPR gene editing Methods 0.000 claims 2
- 229940126289 DNA-PK inhibitor Drugs 0.000 claims 2
- 102000004190 Enzymes Human genes 0.000 claims 2
- 108090000790 Enzymes Proteins 0.000 claims 2
- 108020004682 Single-Stranded DNA Proteins 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 210000003958 hematopoietic stem cell Anatomy 0.000 claims 2
- 229940121372 histone deacetylase inhibitor Drugs 0.000 claims 2
- 239000003276 histone deacetylase inhibitor Substances 0.000 claims 2
- 210000004263 induced pluripotent stem cell Anatomy 0.000 claims 2
- 210000001778 pluripotent stem cell Anatomy 0.000 claims 2
- RTKIYFITIVXBLE-UHFFFAOYSA-N Trichostatin A Natural products ONC(=O)C=CC(C)=CC(C)C(=O)C1=CC=C(N(C)C)C=C1 RTKIYFITIVXBLE-UHFFFAOYSA-N 0.000 claims 1
- PXYRCOIAFZBLBN-UHFFFAOYSA-N ac1l6p4i Chemical compound C12CC(C(C3C(O)=O)C(O)=O)C(C(C)C)=CC23CCC2C1(C)CCCC2(C)C(O)=O PXYRCOIAFZBLBN-UHFFFAOYSA-N 0.000 claims 1
- 210000003527 eukaryotic cell Anatomy 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 108020004707 nucleic acids Proteins 0.000 claims 1
- 102000039446 nucleic acids Human genes 0.000 claims 1
- 150000007523 nucleic acids Chemical class 0.000 claims 1
- 210000000130 stem cell Anatomy 0.000 claims 1
- MPUQHZXIXSTTDU-QXGSTGNESA-N sulfamic acid [(1S,2S,4R)-4-[4-[[(1S)-2,3-dihydro-1H-inden-1-yl]amino]-7-pyrrolo[2,3-d]pyrimidinyl]-2-hydroxycyclopentyl]methyl ester Chemical compound C1[C@H](O)[C@H](COS(=O)(=O)N)C[C@H]1N1C2=NC=NC(N[C@@H]3C4=CC=CC=C4CC3)=C2C=C1 MPUQHZXIXSTTDU-QXGSTGNESA-N 0.000 claims 1
- RTKIYFITIVXBLE-QEQCGCAPSA-N trichostatin A Chemical compound ONC(=O)/C=C/C(/C)=C/[C@@H](C)C(=O)C1=CC=C(N(C)C)C=C1 RTKIYFITIVXBLE-QEQCGCAPSA-N 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023052030A JP2023093479A (ja) | 2017-04-10 | 2023-03-28 | ゲノム編集効率を増大させるための化合物 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP17165784.4A EP3388517A1 (en) | 2017-04-10 | 2017-04-10 | Compounds for increasing genome editing efficiency |
| EP17165784.4 | 2017-04-10 | ||
| EP17203591.7 | 2017-11-24 | ||
| EP17203591.7A EP3489357A1 (en) | 2017-11-24 | 2017-11-24 | Compounds for increasing genome editing efficiency |
| PCT/EP2018/059173 WO2018189186A1 (en) | 2017-04-10 | 2018-04-10 | Compounds for increasing genome editing efficiency |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023052030A Division JP2023093479A (ja) | 2017-04-10 | 2023-03-28 | ゲノム編集効率を増大させるための化合物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020516258A JP2020516258A (ja) | 2020-06-11 |
| JP2020516258A5 true JP2020516258A5 (enExample) | 2021-05-20 |
| JP7319194B2 JP7319194B2 (ja) | 2023-08-01 |
Family
ID=62116381
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019555112A Active JP7319194B2 (ja) | 2017-04-10 | 2018-04-10 | ゲノム編集効率を増大させるための化合物 |
| JP2023052030A Pending JP2023093479A (ja) | 2017-04-10 | 2023-03-28 | ゲノム編集効率を増大させるための化合物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023052030A Pending JP2023093479A (ja) | 2017-04-10 | 2023-03-28 | ゲノム編集効率を増大させるための化合物 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US12173309B2 (enExample) |
| EP (1) | EP3610008A1 (enExample) |
| JP (2) | JP7319194B2 (enExample) |
| KR (2) | KR102778328B1 (enExample) |
| CN (1) | CN110691848B (enExample) |
| CA (1) | CA3058697A1 (enExample) |
| IL (1) | IL269887B2 (enExample) |
| SG (1) | SG11201909432SA (enExample) |
| WO (1) | WO2018189186A1 (enExample) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019051316A1 (en) * | 2017-09-08 | 2019-03-14 | Life Technologies Corporation | ENHANCED APPROVAL RECOMBINATION METHODS AND COMPOSITIONS THEREOF |
| JP7235153B2 (ja) * | 2017-12-29 | 2023-03-08 | 株式会社三洋物産 | 遊技機 |
| JP7483612B2 (ja) | 2018-01-17 | 2024-05-15 | バーテックス ファーマシューティカルズ インコーポレイテッド | ゲノム編集効率を増加するためのキノキサリノン化合物、組成物、方法、およびキット |
| CN111741955B (zh) * | 2018-01-17 | 2024-02-23 | 沃泰克斯药物股份有限公司 | Dna-pk抑制剂 |
| JP7235154B2 (ja) * | 2018-02-15 | 2023-03-08 | 株式会社三洋物産 | 遊技機 |
| JP7231076B2 (ja) * | 2018-03-08 | 2023-03-01 | 株式会社三洋物産 | 遊技機 |
| EP3911330B1 (en) | 2018-12-21 | 2025-03-05 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Dna-pkcs inhibitors for increasing genome editing efficiency |
| JP2020103418A (ja) * | 2018-12-26 | 2020-07-09 | 株式会社三洋物産 | 遊技機 |
| JP2020130466A (ja) * | 2019-02-15 | 2020-08-31 | 株式会社三洋物産 | 遊技機 |
| JP7234740B2 (ja) * | 2019-03-28 | 2023-03-08 | 株式会社三洋物産 | 遊技機 |
| JP7234741B2 (ja) * | 2019-03-28 | 2023-03-08 | 株式会社三洋物産 | 遊技機 |
| JP7234761B2 (ja) * | 2019-04-11 | 2023-03-08 | 株式会社三洋物産 | 遊技機 |
| JP7234760B2 (ja) * | 2019-04-11 | 2023-03-08 | 株式会社三洋物産 | 遊技機 |
| JP2021186294A (ja) * | 2020-05-29 | 2021-12-13 | 株式会社三洋物産 | 遊技機 |
| CN112359065B (zh) * | 2020-09-21 | 2023-04-07 | 中国医学科学院血液病医院(中国医学科学院血液学研究所) | 一种提高基因敲入效率的小分子组合物 |
| KR102545913B1 (ko) * | 2021-02-02 | 2023-06-22 | 재단법인 아산사회복지재단 | 히스톤 탈아세틸화 억제제를 포함하는 염기교정 기술의 효율성 및 정확도 향상용 조성물 및 이의 용도 |
| EP4347815A2 (en) * | 2021-05-24 | 2024-04-10 | New York Genome Center, Inc. | Compositions and methods for increasing efficiency of precise editing repair |
| CN113403309B (zh) * | 2021-05-24 | 2022-08-16 | 珠海舒桐医疗科技有限公司 | 非同源双链寡聚核苷酸片段在基因敲除系统中的应用 |
| EP4095246A1 (en) | 2021-05-27 | 2022-11-30 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Novel crispr grnas |
| US20230070047A1 (en) * | 2021-07-06 | 2023-03-09 | Regents Of The University Of Minnesota | Method to enhance gene editing |
| JP2023105110A (ja) * | 2021-10-27 | 2023-07-28 | 株式会社三洋物産 | 遊技機 |
| JP2023105108A (ja) * | 2021-10-27 | 2023-07-28 | 株式会社三洋物産 | 遊技機 |
| JP2023105111A (ja) * | 2021-10-27 | 2023-07-28 | 株式会社三洋物産 | 遊技機 |
| JP2023063369A (ja) * | 2022-01-07 | 2023-05-09 | 株式会社三洋物産 | 遊技機 |
| JP2023053387A (ja) * | 2022-02-04 | 2023-04-12 | 株式会社三洋物産 | 遊技機 |
| JP2023060269A (ja) * | 2022-04-01 | 2023-04-27 | 株式会社三洋物産 | 遊技機 |
| JP2023060270A (ja) * | 2022-04-01 | 2023-04-27 | 株式会社三洋物産 | 遊技機 |
| CN114717207B (zh) * | 2022-04-25 | 2023-03-07 | 苏州泓迅生物科技股份有限公司 | 一种酵母细胞同源重组酶系、dna体外组装试剂及其应用 |
| WO2025212548A1 (en) | 2024-04-02 | 2025-10-09 | Sigma-Aldrich Co. Llc | Methods and compositions for improvement of base editor and homology directed repair genome editing outcomes |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013188881A1 (en) | 2012-06-15 | 2013-12-19 | President And Fellows Of Harvard College | Compounds, compositions and methods for treating or preventing neurodegenerative disorders |
| CA2901676C (en) * | 2013-02-25 | 2023-08-22 | Sangamo Biosciences, Inc. | Methods and compositions for enhancing nuclease-mediated gene disruption |
| CN107995927B (zh) * | 2013-06-17 | 2021-07-30 | 布罗德研究所有限公司 | 用于肝靶向和治疗的crispr-cas系统、载体和组合物的递送与用途 |
| US9970030B2 (en) * | 2014-08-27 | 2018-05-15 | Caribou Biosciences, Inc. | Methods for increasing CAS9-mediated engineering efficiency |
| AU2015342749B2 (en) * | 2014-11-07 | 2022-01-27 | Editas Medicine, Inc. | Methods for improving CRISPR/Cas-mediated genome-editing |
-
2018
- 2018-04-10 CN CN201880035645.5A patent/CN110691848B/zh active Active
- 2018-04-10 SG SG11201909432S patent/SG11201909432SA/en unknown
- 2018-04-10 JP JP2019555112A patent/JP7319194B2/ja active Active
- 2018-04-10 US US16/603,377 patent/US12173309B2/en active Active
- 2018-04-10 WO PCT/EP2018/059173 patent/WO2018189186A1/en not_active Ceased
- 2018-04-10 KR KR1020237017487A patent/KR102778328B1/ko active Active
- 2018-04-10 IL IL269887A patent/IL269887B2/en unknown
- 2018-04-10 KR KR1020197032518A patent/KR102537447B1/ko active Active
- 2018-04-10 EP EP18722407.6A patent/EP3610008A1/en active Pending
- 2018-04-10 CA CA3058697A patent/CA3058697A1/en active Pending
-
2023
- 2023-03-28 JP JP2023052030A patent/JP2023093479A/ja active Pending
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