JP2020515272A5 - - Google Patents
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- JP2020515272A5 JP2020515272A5 JP2019553883A JP2019553883A JP2020515272A5 JP 2020515272 A5 JP2020515272 A5 JP 2020515272A5 JP 2019553883 A JP2019553883 A JP 2019553883A JP 2019553883 A JP2019553883 A JP 2019553883A JP 2020515272 A5 JP2020515272 A5 JP 2020515272A5
- Authority
- JP
- Japan
- Prior art keywords
- chimeric polypeptide
- polypeptide
- complex
- fusion protein
- ectdomain
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 108090000765 processed proteins & peptides Proteins 0.000 claims 105
- 102000004196 processed proteins & peptides Human genes 0.000 claims 104
- 229920001184 polypeptide Polymers 0.000 claims 103
- 108020001507 fusion proteins Proteins 0.000 claims 22
- 102000037865 fusion proteins Human genes 0.000 claims 22
- 239000000203 mixture Substances 0.000 claims 15
- 108010059722 Viral Fusion Proteins Proteins 0.000 claims 14
- 241000700605 Viruses Species 0.000 claims 12
- 150000001413 amino acids Chemical class 0.000 claims 10
- 239000000427 antigen Substances 0.000 claims 9
- 102000036639 antigens Human genes 0.000 claims 9
- 108091007433 antigens Proteins 0.000 claims 9
- 210000004027 cell Anatomy 0.000 claims 9
- 238000000034 method Methods 0.000 claims 9
- 108020004707 nucleic acids Proteins 0.000 claims 9
- 102000039446 nucleic acids Human genes 0.000 claims 9
- 150000007523 nucleic acids Chemical class 0.000 claims 9
- 239000008194 pharmaceutical composition Substances 0.000 claims 8
- 125000003275 alpha amino acid group Chemical group 0.000 claims 6
- 125000000539 amino acid group Chemical group 0.000 claims 6
- 239000003795 chemical substances by application Substances 0.000 claims 6
- 230000004927 fusion Effects 0.000 claims 6
- 238000004519 manufacturing process Methods 0.000 claims 6
- 230000000087 stabilizing effect Effects 0.000 claims 6
- 239000007864 aqueous solution Substances 0.000 claims 5
- 230000028993 immune response Effects 0.000 claims 5
- 108091033319 polynucleotide Proteins 0.000 claims 5
- 102000040430 polynucleotide Human genes 0.000 claims 5
- 239000002157 polynucleotide Substances 0.000 claims 5
- 230000000295 complement effect Effects 0.000 claims 4
- 238000006384 oligomerization reaction Methods 0.000 claims 4
- 230000008878 coupling Effects 0.000 claims 3
- 238000010168 coupling process Methods 0.000 claims 3
- 238000005859 coupling reaction Methods 0.000 claims 3
- 229940079593 drug Drugs 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 230000002209 hydrophobic effect Effects 0.000 claims 3
- 230000009385 viral infection Effects 0.000 claims 3
- 241000712891 Arenavirus Species 0.000 claims 2
- 241000711573 Coronaviridae Species 0.000 claims 2
- 108010041986 DNA Vaccines Proteins 0.000 claims 2
- 229940021995 DNA vaccine Drugs 0.000 claims 2
- 101710189136 Envelope fusion protein Proteins 0.000 claims 2
- 108091005804 Peptidases Proteins 0.000 claims 2
- 239000004365 Protease Substances 0.000 claims 2
- 239000002671 adjuvant Substances 0.000 claims 2
- 210000003719 b-lymphocyte Anatomy 0.000 claims 2
- 230000015572 biosynthetic process Effects 0.000 claims 2
- 238000003776 cleavage reaction Methods 0.000 claims 2
- 239000003085 diluting agent Substances 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 230000013595 glycosylation Effects 0.000 claims 2
- 238000006206 glycosylation reaction Methods 0.000 claims 2
- 230000002519 immonomodulatory effect Effects 0.000 claims 2
- 150000002632 lipids Chemical class 0.000 claims 2
- 229920002521 macromolecule Polymers 0.000 claims 2
- 108020004999 messenger RNA Proteins 0.000 claims 2
- 230000006337 proteolytic cleavage Effects 0.000 claims 2
- 230000007017 scission Effects 0.000 claims 2
- 150000003384 small molecules Chemical class 0.000 claims 2
- 241001430294 unidentified retrovirus Species 0.000 claims 2
- 239000013603 viral vector Substances 0.000 claims 2
- 241000282836 Camelus dromedarius Species 0.000 claims 1
- 241000251730 Chondrichthyes Species 0.000 claims 1
- 108091026890 Coding region Proteins 0.000 claims 1
- 102000004190 Enzymes Human genes 0.000 claims 1
- 108090000790 Enzymes Proteins 0.000 claims 1
- 241000711950 Filoviridae Species 0.000 claims 1
- 102000004961 Furin Human genes 0.000 claims 1
- 108090001126 Furin Proteins 0.000 claims 1
- 102000051366 Glycosyltransferases Human genes 0.000 claims 1
- 108700023372 Glycosyltransferases Proteins 0.000 claims 1
- 108060003951 Immunoglobulin Proteins 0.000 claims 1
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 1
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- 241001465754 Metazoa Species 0.000 claims 1
- 102000035195 Peptidases Human genes 0.000 claims 1
- 239000002202 Polyethylene glycol Substances 0.000 claims 1
- 108010076504 Protein Sorting Signals Proteins 0.000 claims 1
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 230000030279 gene silencing Effects 0.000 claims 1
- 230000005745 host immune response Effects 0.000 claims 1
- 102000018358 immunoglobulin Human genes 0.000 claims 1
- 230000003308 immunostimulating effect Effects 0.000 claims 1
- 230000006698 induction Effects 0.000 claims 1
- 238000002955 isolation Methods 0.000 claims 1
- 239000012528 membrane Substances 0.000 claims 1
- 230000003472 neutralizing effect Effects 0.000 claims 1
- 239000002245 particle Substances 0.000 claims 1
- 229920001223 polyethylene glycol Polymers 0.000 claims 1
- 239000002243 precursor Substances 0.000 claims 1
- 238000000746 purification Methods 0.000 claims 1
- 230000001105 regulatory effect Effects 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
- 241001529453 unidentified herpesvirus Species 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023034197A JP2023071901A (ja) | 2017-03-30 | 2023-03-07 | キメラ分子およびその使用 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU2017901152 | 2017-03-30 | ||
| AU2017901152A AU2017901152A0 (en) | 2017-03-30 | Chimeric molecules and uses thereof | |
| PCT/AU2018/050299 WO2018176103A1 (en) | 2017-03-30 | 2018-03-29 | "chimeric molecules and uses thereof" |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023034197A Division JP2023071901A (ja) | 2017-03-30 | 2023-03-07 | キメラ分子およびその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020515272A JP2020515272A (ja) | 2020-05-28 |
| JP2020515272A5 true JP2020515272A5 (https=) | 2021-05-20 |
| JP7291398B2 JP7291398B2 (ja) | 2023-06-15 |
Family
ID=63675061
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019553883A Active JP7291398B2 (ja) | 2017-03-30 | 2018-03-29 | キメラ分子およびその使用 |
| JP2023034197A Pending JP2023071901A (ja) | 2017-03-30 | 2023-03-07 | キメラ分子およびその使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023034197A Pending JP2023071901A (ja) | 2017-03-30 | 2023-03-07 | キメラ分子およびその使用 |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US11254712B2 (https=) |
| EP (2) | EP3601367B1 (https=) |
| JP (2) | JP7291398B2 (https=) |
| KR (2) | KR20260047644A (https=) |
| CN (1) | CN110506060B (https=) |
| AU (1) | AU2018241252C1 (https=) |
| BR (1) | BR112019019813A2 (https=) |
| CA (1) | CA3057171A1 (https=) |
| DK (1) | DK3601367T3 (https=) |
| ES (1) | ES3001108T3 (https=) |
| IL (1) | IL269534B2 (https=) |
| MX (1) | MX2019011599A (https=) |
| NZ (1) | NZ757178A (https=) |
| PL (1) | PL3601367T3 (https=) |
| SG (1) | SG11201908280SA (https=) |
| WO (1) | WO2018176103A1 (https=) |
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| JP5711972B2 (ja) * | 2007-12-24 | 2015-05-07 | アイディー バイオメディカル コーポレイション オブ ケベック | 組換えｒｓｖ抗原 |
| CA2768186A1 (en) | 2009-07-15 | 2011-01-20 | Novartis Ag | Rsv f protein compositions and methods for making same |
| CA2835644C (en) | 2011-05-13 | 2021-06-15 | Novartis Ag | Pre-fusion rsv f antigens |
| SG11202008914WA (en) | 2018-02-15 | 2020-10-29 | Caretech Services Pty Ltd | A platform and system for use in therapeutic procedures |
| CA3116292A1 (en) | 2018-10-25 | 2020-04-30 | Km Biologics Co., Ltd. | Modified cmv gb protein and cmv vaccine including same |
| KR20240137107A (ko) * | 2019-07-16 | 2024-09-19 | 길리애드 사이언시즈, 인코포레이티드 | Hiv 백신, 및 이의 제조 및 사용 방법 |
| WO2021014385A1 (en) * | 2019-07-24 | 2021-01-28 | Glaxosmithkline Biologicals Sa | Modified human cytomegalovirus proteins |
| US20230054711A1 (en) * | 2019-12-31 | 2023-02-23 | Xiamen University | Multimerization delivery system for intracellular delivery of molecule |
| PH12022551788A1 (en) * | 2020-01-28 | 2024-02-26 | Codagenix Inc | DEOPTIMIZED SARS-CoV-2 AND METHODS AND USES THEREOF |
| CN113498417B (zh) * | 2020-02-05 | 2022-11-01 | 山西锦波生物医药股份有限公司 | 多肽、其制备方法和用途 |
| CN115768784A (zh) * | 2020-02-06 | 2023-03-07 | 勃林格殷格翰动物保健有限公司 | 用于检测抗弹状病毒抗体的多肽 |
| CN112300251B (zh) * | 2020-02-24 | 2022-04-05 | 成都威斯克生物医药有限公司 | 抗SARS-CoV-2感染的蛋白及疫苗 |
| WO2021216560A2 (en) * | 2020-04-20 | 2021-10-28 | Richard Ascione | Vaccine compositions for sars-related coronaviruses and methods of use |
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| WO2021229270A1 (es) | 2020-05-13 | 2021-11-18 | Laboratorio Avi-Mex, S.A. De C.V. | Vacuna recombinante contra covid-19 en vector viral |
| EP4164682A1 (en) * | 2020-06-10 | 2023-04-19 | Bavarian Nordic A/S | A recombinant modified vaccinia virus ankara (mva) vaccine against coronavirus disease |
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| AU2021333886A1 (en) * | 2020-08-26 | 2023-05-04 | The University Of Queensland | Modified polypeptides with improved properties |
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| WO2022248353A1 (en) | 2021-05-24 | 2022-12-01 | Glaxosmithkline Biologicals Sa | Adjuvants |
| CA3222568A1 (en) * | 2021-06-28 | 2023-01-05 | Glaxosmithkline Biologicals Sa | Novel influenza antigens |
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| EP4169513A1 (en) | 2021-10-19 | 2023-04-26 | GlaxoSmithKline Biologicals S.A. | Adjuvant composition comprising sting agonists |
| CN119487052A (zh) * | 2022-03-31 | 2025-02-18 | 昆士兰大学 | 改进的嵌合多肽及其用途 |
| WO2023196945A2 (en) * | 2022-04-08 | 2023-10-12 | Icahn School Of Medicine At Mount Sinai | Recombinant newcastle disease virus expressing lassa virus gp or np, and uses thereof |
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| CN116789847B (zh) * | 2023-01-13 | 2024-04-16 | 广州医科大学附属第一医院（广州呼吸中心） | 融合蛋白、病毒样颗粒以及疫苗 |
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| CN119978144B (zh) * | 2025-02-14 | 2025-10-17 | 嘉译生物医药(杭州)有限公司 | 一种hMPV病毒融合蛋白F变体、mRNA疫苗及其应用 |
| CN119841911B (zh) * | 2025-03-18 | 2025-10-28 | 北京华诺泰生物医药科技有限公司 | 一种人偏肺病毒f蛋白突变体及其应用 |
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- 2018-03-29 WO PCT/AU2018/050299 patent/WO2018176103A1/en not_active Ceased
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