MX2022013934A - Virus de la enfermedad de newcastle recombinante que expresa la proteina de espicula de sars-cov-2 y usos del mismo. - Google Patents
Virus de la enfermedad de newcastle recombinante que expresa la proteina de espicula de sars-cov-2 y usos del mismo.Info
- Publication number
- MX2022013934A MX2022013934A MX2022013934A MX2022013934A MX2022013934A MX 2022013934 A MX2022013934 A MX 2022013934A MX 2022013934 A MX2022013934 A MX 2022013934A MX 2022013934 A MX2022013934 A MX 2022013934A MX 2022013934 A MX2022013934 A MX 2022013934A
- Authority
- MX
- Mexico
- Prior art keywords
- cov
- protein
- sars
- newcastle disease
- spike protein
- Prior art date
Links
- 241000711404 Avian avulavirus 1 Species 0.000 title abstract 6
- 101000629318 Severe acute respiratory syndrome coronavirus 2 Spike glycoprotein Proteins 0.000 title abstract 3
- 108010068327 4-hydroxyphenylpyruvate dioxygenase Proteins 0.000 abstract 3
- 108700019146 Transgenes Proteins 0.000 abstract 2
- 208000025721 COVID-19 Diseases 0.000 abstract 1
- 241001678559 COVID-19 virus Species 0.000 abstract 1
- 108091006197 SARS-CoV-2 Nucleocapsid Protein Proteins 0.000 abstract 1
- 230000001086 cytosolic effect Effects 0.000 abstract 1
- 230000003053 immunization Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/215—Coronaviridae, e.g. avian infectious bronchitis virus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5256—Virus expressing foreign proteins
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
- C07K2319/21—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a His-tag
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/18011—Paramyxoviridae
- C12N2760/18111—Avulavirus, e.g. Newcastle disease virus
- C12N2760/18141—Use of virus, viral particle or viral elements as a vector
- C12N2760/18143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/20011—Coronaviridae
- C12N2770/20022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/20011—Coronaviridae
- C12N2770/20034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Virology (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- Communicable Diseases (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Mycology (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Pulmonology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
En el presente documento se describen virus de la enfermedad de Newcastle recombinantes ("NDVs") que comprenden un genoma empaquetado, en donde el genoma empaquetado comprende un transgén que comprende una secuencia de nucleótidos que codifica para una proteína de espícula o proteína de nucleocápside del SARS-CoV-2. También se describen en el presente documento NDVs recombinantes que comprenden un genoma empaquetado, en donde el genoma empaquetado comprende un transgén que codifica para una proteína F quimérica, en donde la proteína F quimérica comprende un ectodominio de proteína de espícula del SARS-CoV-2 y dominios citoplásmico y de transmembrana de la proteína F del NDV. Los NDVs recombinantes y sus composiciones son útiles para la inmunización contra el SARS-CoV-2 así como para la prevención de la COVID-19.
Applications Claiming Priority (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US202063021677P | 2020-05-07 | 2020-05-07 | |
US202063051858P | 2020-07-14 | 2020-07-14 | |
US202063057267P | 2020-07-27 | 2020-07-27 | |
US202063058435P | 2020-07-29 | 2020-07-29 | |
US202063059924P | 2020-07-31 | 2020-07-31 | |
PCT/US2021/022848 WO2021194826A2 (en) | 2020-03-24 | 2021-03-17 | Recombinant sars-cov-2 spike protein and uses thereof |
PCT/US2021/031110 WO2021226348A2 (en) | 2020-05-07 | 2021-05-06 | Recombinant newcastle disease virus expressing sars-cov-2 spike protein and uses thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2022013934A true MX2022013934A (es) | 2023-02-22 |
Family
ID=78468787
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2022013934A MX2022013934A (es) | 2020-05-07 | 2021-05-06 | Virus de la enfermedad de newcastle recombinante que expresa la proteina de espicula de sars-cov-2 y usos del mismo. |
Country Status (7)
Country | Link |
---|---|
US (1) | US20230310583A1 (es) |
EP (1) | EP4146674A2 (es) |
JP (1) | JP2023524990A (es) |
BR (1) | BR112022022604A2 (es) |
CA (1) | CA3178875A1 (es) |
MX (1) | MX2022013934A (es) |
WO (1) | WO2021226348A2 (es) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN113881704B (zh) * | 2021-11-17 | 2024-02-13 | 浙江迪福润丝生物科技有限公司 | 一种包含新型冠状病毒双抗原靶标序列组合的重组新城疫病毒载体及相应疫苗株和疫苗 |
CN114196701B (zh) * | 2021-11-17 | 2023-10-10 | 浙江迪福润丝生物科技有限公司 | 一种sars-cov-2的二价重组新城疫病毒载体及相应疫苗株和制备方法 |
CN114213547A (zh) * | 2021-12-16 | 2022-03-22 | 浙江迪福润丝生物科技有限公司 | 一种展示新冠s蛋白的融合蛋白和重组病毒粒子及其应用 |
WO2023173032A2 (en) * | 2022-03-10 | 2023-09-14 | Icahn School Of Medicine At Mount Sinai | Recombinant newcastle disease viruses and immunogenic compositions for use in preventing covid-19 |
WO2023196759A2 (en) * | 2022-04-03 | 2023-10-12 | Icahn School Of Medicine At Mount Sinai | Recombinant newcastle disease viruses and immunogenic compositions for use in immunizing against sars-cov-2 omicron variant |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PL2251034T3 (pl) * | 2005-12-02 | 2018-07-31 | Icahn School Of Medicine At Mount Sinai | Chimeryczne wirusy prezentujące nienatywne białka powierzchniowe i zastosowania tych wirusów |
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2021
- 2021-05-06 MX MX2022013934A patent/MX2022013934A/es unknown
- 2021-05-06 US US17/922,777 patent/US20230310583A1/en active Pending
- 2021-05-06 CA CA3178875A patent/CA3178875A1/en active Pending
- 2021-05-06 WO PCT/US2021/031110 patent/WO2021226348A2/en unknown
- 2021-05-06 JP JP2022567321A patent/JP2023524990A/ja active Pending
- 2021-05-06 BR BR112022022604A patent/BR112022022604A2/pt unknown
- 2021-05-06 EP EP21800838.1A patent/EP4146674A2/en active Pending
Also Published As
Publication number | Publication date |
---|---|
WO2021226348A3 (en) | 2021-12-09 |
EP4146674A2 (en) | 2023-03-15 |
WO2021226348A2 (en) | 2021-11-11 |
US20230310583A1 (en) | 2023-10-05 |
BR112022022604A2 (pt) | 2023-03-28 |
JP2023524990A (ja) | 2023-06-14 |
CA3178875A1 (en) | 2021-11-11 |
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